TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.497 | Formula: C20H16N4O2S2
H donors: 1 H acceptors: 4 LogP: 4.21 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Sc1nccc(n1)c1ccc2c(c1)sc(n2)NC(=O)C
InChi: 1S/C20H16N4O2S2/c1-12(25)22-20-24-17-8-3-13(11-18(17)28-20)16-9-10-21-19(23-16)27-15-6-4-14(26-2)5-7-15/h3-11H,1-2H3,(H,22,24,25)
InChiKey: CYLXABNZYVTFFR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	References
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0226	0.2645	0.2645
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0361	0.0605
Loa Loa (eye worm)	cytochrome P450 family protein	0.0034	0.0116	0.0194
Brugia malayi	hypothetical protein	0.0038	0.0159	0.0263
Trichomonas vaginalis	guanylate cyclase, putative	0.0037	0.0152	0.0099
Loa Loa (eye worm)	hypothetical protein	0.005	0.0325	0.0545
Schistosoma mansoni	hypothetical protein	0.0072	0.0617	0.1315
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0258	0.3074	0.5154
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0122	0.127	0.2081
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0038	0.0159	0.0266
Loa Loa (eye worm)	phosphatidylinositol 3	0.0202	0.2326	0.3901
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1465	0.2458
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0058	0.0429	0.0429
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0258	0.3074	0.3303
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0529	0.1126
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0529	0.0887
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.016	0.1773	0.2974
Schistosoma mansoni	hypothetical protein	0.0166	0.1849	0.395
Toxoplasma gondii	exonuclease III APE	0.0039	0.0182	0.1691
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0137	0.1465	0.3128
Schistosoma mansoni	lamin	0.0053	0.0361	0.0766
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0133	0.0067
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0105	0.0113
Trichomonas vaginalis	set domain proteins, putative	0.046	0.5738	1
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0038	0.0159	0.0159
Brugia malayi	Nuclear hormone receptor-like 1	0.0258	0.3074	0.5154
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0085	0.0782	0.1215
Schistosoma mansoni	hypothetical protein	0.0033	0.0105	0.0219
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0132	0.0063
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0058	0.0426	0.0458
Brugia malayi	hypothetical protein	0.0098	0.0956	0.16
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0286	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0266
Schistosoma mansoni	retinoic acid receptor RXR	0.0258	0.3074	0.6568
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.0132	0.0063
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.1038	0.1738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0426	0.0585
Schistosoma mansoni	multiple ankyrin repeats single kh domain protein	0.0087	0.0809	0.1726
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0058	0.0429	0.0429
Schistosoma mansoni	hypothetical protein	0.0166	0.1849	0.395
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0055	0.0395	0.0395
Echinococcus granulosus	GA binding protein alpha chain	0.0081	0.0737	0.0791
Brugia malayi	hypothetical protein	0.0231	0.2714	0.455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0138	0.0074
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0058	0.0426	0.2687
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0132	0.0217
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0081	0.0737	0.1235
Onchocerca volvulus		0.0122	0.1272	0.2006
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.005	0.0323	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1465	0.2458
Brugia malayi	tailless protein	0.0122	0.1272	0.2131
Schistosoma mansoni	thyroid hormone receptor	0.038	0.4679	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0258	0.3074	0.5154
Mycobacterium ulcerans	putative regulatory protein	0.0105	0.1053	1
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0071	0.0602	0.0602
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0043	0.0232	0.0241
Echinococcus granulosus	Regulator of G protein signaling 20	0.0038	0.0159	0.0171
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0182	0.0153
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0529	0.0887
Echinococcus granulosus	axis inhibition protein axin	0.0038	0.0159	0.0171
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0159	0.0112
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0037	0.0152	0.0152
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0122	0.1272	0.1367
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0182	0.0301
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0122	0.127	0.2128
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0258	0.3074	0.5154
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0159	0.0335
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0279	0.0325
Loa Loa (eye worm)	nuclear hormone receptor	0.0122	0.1272	0.2134
Onchocerca volvulus	Huntingtin homolog	0.012	0.125	0.1965
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0258	0.3074	0.6568
Echinococcus granulosus	regulator of G protein signaling 3	0.0038	0.0159	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0477	0.5962	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0122	0.1272	0.2134
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.1268	0.1363
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0037	0.0152	0.0099
Schistosoma mansoni	alpha-glucosidase	0.0138	0.1479	0.3158
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0258	0.3074	0.3303
Loa Loa (eye worm)	cytochrome P450 family protein	0.0036	0.0138	0.0231
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0258	0.3074	0.3303
Schistosoma mansoni	hypothetical protein	0.0122	0.1268	0.2707
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0258	0.3074	0.6568
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.2714	0.2714
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0258	0.3074	0.5156
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0138	0.0074
Loa Loa (eye worm)	DR-78	0.0122	0.1272	0.2134
Entamoeba histolytica	hypothetical protein	0.0221	0.258	1
Echinococcus granulosus	lamin dm0	0.0053	0.0361	0.0387
Brugia malayi	Fli-1 protein	0.0247	0.2921	0.4897
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0182	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0159	0.0112
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0221	0.258	0.258
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0429	0.072
Toxoplasma gondii	isocitrate dehydrogenase	0.005	0.0323	0.6415
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0159	0.0335
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0037	0.0152	0.0152
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.0132	0.0063
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.005	0.0323	0.7531
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0038	0.0159	0.0335
Loa Loa (eye worm)	abnormal epIthelia family member	0.005	0.0325	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0956	0.1604
Brugia malayi	A-kinase anchor protein 10, precursor	0.0038	0.0159	0.0263
Echinococcus multilocularis	regulator of G protein signaling 7	0.0038	0.0159	0.0159
Trypanosoma brucei	glucosidase, putative	0.0035	0.0132	0.2972
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0122	0.1272	0.1367
Schistosoma mansoni	alpha-glucosidase	0.0138	0.1479	0.3158
Echinococcus multilocularis	musashi	0.0053	0.0361	0.0361
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0038	0.0159	0.0159
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0122	0.127	0.2081
Echinococcus granulosus	regulator of G protein signaling 7	0.0038	0.0159	0.0171
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.005	0.0323	0.1791
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0037	0.0152	0.031
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0182	0.5
Entamoeba histolytica	hypothetical protein	0.0038	0.0159	0.0111
Onchocerca volvulus		0.0146	0.159	0.2574
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0058	0.0426	0.2687
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.005	0.0323	0.0323
Echinococcus granulosus	Smad4	0.0026	0.0002	0.0003
Schistosoma mansoni	nuclear hormone receptor	0.0258	0.3074	0.6568
Echinococcus multilocularis	neurogenic locus notch protein	0.005	0.0325	0.0325
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0159	0.0112
Brugia malayi	PXA domain containing protein	0.0038	0.0159	0.0263
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0132	0.0063
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0258	0.3074	0.5154
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0058	0.0426	0.0711
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0122	0.1272	0.1367
Leishmania major	protein kinase, putative	0.0037	0.0152	0.1155
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0258	0.3074	0.5156
Brugia malayi	hypothetical protein	0.0122	0.1272	0.2131
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.1268	0.1268
Brugia malayi	TAR-binding protein	0.0066	0.0529	0.0883
Loa Loa (eye worm)	fli-1 protein	0.0247	0.2921	0.4899
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0132	0.0063
Brugia malayi	hypothetical protein	0.0146	0.159	0.2664
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.005	0.0323	1
Entamoeba histolytica	hypothetical protein	0.0221	0.258	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0122	0.1272	0.1367
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0026	0.0002	0.0003
Echinococcus granulosus	neuropeptide s receptor	0.0448	0.5578	0.5994
Brugia malayi	nuclear hormone receptor	0.0258	0.3074	0.5154
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0037	0.0152	0.0099
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0182	0.0153
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0085	0.0782	0.1215
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0037	0.0152	0.5
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0044	0.0242	0.3722
Schistosoma mansoni	nuclear hormone receptor	0.0122	0.1272	0.2716
Loa Loa (eye worm)	MH2 domain-containing protein	0.0377	0.4635	0.7774
Echinococcus multilocularis	lysosomal alpha glucosidase	0.016	0.1773	0.1773
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0152	0.0099
Echinococcus granulosus	neuropeptide receptor A26	0.0448	0.5578	0.5994
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0258	0.3074	0.5154
Schistosoma mansoni	hypothetical protein	0.0033	0.0105	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2714	0.4552
Leishmania major	alpha glucosidase II subunit, putative	0.0035	0.0132	0.0515
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0058	0.0426	0.1202
Schistosoma mansoni	transcription factor LCR-F1	0.0221	0.258	0.5511
Brugia malayi	hypothetical protein	0.0038	0.0159	0.0263
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.0721	0.0774
Brugia malayi	Cytochrome P450 family protein	0.0034	0.0116	0.019
Loa Loa (eye worm)	MH1 domain-containing protein	0.0026	0.0002	0.0004
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0058	0.0426	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0258	0.3074	0.3074
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0346	0.058
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0137	0.1465	0.2458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0321	0.0399
Loa Loa (eye worm)	cytochrome P450 family protein	0.0034	0.0116	0.0194
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0122	0.1272	0.2006
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1465	0.2458
Echinococcus multilocularis	isocitrate dehydrogenase	0.005	0.0323	0.0323
Schistosoma mansoni	zinc finger protein	0.0122	0.1272	0.2716
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0258	0.3074	0.5154
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0159	0.0335
Brugia malayi	ecdysteroid receptor	0.0258	0.3074	0.5154
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0258	0.3074	0.5154
Brugia malayi	Glycosyl hydrolases family 31 protein	0.016	0.1773	0.2971
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0037	0.0152	0.031
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0098	0.0952	0.3349
Echinococcus multilocularis	smad	0.0026	0.0002	0.0002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0988	0.0988
Echinococcus multilocularis	axis inhibition protein axin	0.0038	0.0159	0.0159
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0258	0.3074	0.6568
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0026	0.0002	0.0002
Echinococcus granulosus	Ankyrin repeat domain containing protein	0.0087	0.0809	0.087
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0058	0.0426	0.0906
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.1178	0.4274
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0037	0.0152	0.0099
Onchocerca volvulus		0.0082	0.074	0.1053
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0988	0.2108
Brugia malayi	Ets-domain containing protein	0.0081	0.0737	0.1232
Brugia malayi	nuclear receptor NHR-88	0.0258	0.3074	0.5154
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0132	0.0063
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0182	0.0206
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.005	0.0323	0.0323
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0038	0.0159	0.0335
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0137	0.1465	0.1574
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0182	0.0196
Echinococcus granulosus	histone lysine methyltransferase setb	0.0058	0.0429	0.0461
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.127	1
Echinococcus multilocularis	expressed protein	0.0731	0.9307	0.9307
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0988	0.1062
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0529	0.1126
Brugia malayi	MH2 domain containing protein	0.0377	0.4635	0.7773
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0043	0.0232	0.0385
Onchocerca volvulus		0.0053	0.0361	0.0374
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0026	0.0002	0.0002
Onchocerca volvulus		0.0069	0.0575	0.0757
Entamoeba histolytica	hypothetical protein	0.0098	0.0952	0.3349
Echinococcus granulosus	geminin	0.0166	0.1849	0.1987
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0159	0.0112
Loa Loa (eye worm)	hypothetical protein	0.012	0.125	0.2096
Onchocerca volvulus	Huntingtin homolog	0.012	0.125	0.1965
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.01	0.0988	0.1658
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0258	0.3074	0.3074
Brugia malayi	regulator of G-protein signaling egl-10	0.0038	0.0159	0.0263
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0105	0.0172
Giardia lamblia	GTOR	0.0058	0.0426	0.9047
Echinococcus granulosus	nuclear receptor nhr 48	0.0122	0.1272	0.1367
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.074	0.074
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0152	0.0099
Loa Loa (eye worm)	transcription factor SMAD2	0.0377	0.4635	0.7774
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1058	0.1775
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0159	0.0335
Echinococcus multilocularis	lamin	0.0053	0.0361	0.0361
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0226	0.2645	0.5651
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0429	0.0913
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0159	0.0335
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0105	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3074	0.5156
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0258	0.3074	0.6568
Echinococcus granulosus	slit 2 protein	0.005	0.0325	0.0349
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0037	0.0152	0.0163
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0258	0.3074	0.5156
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0529	0.1126
Echinococcus granulosus	single minded 2	0.0105	0.1053	0.1132
Brugia malayi	orphan nuclear receptor NR2E1	0.0122	0.1272	0.2131
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0037	0.0152	0.031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0988	0.2108
Schistosoma mansoni	RAR-like nuclear receptor	0.0258	0.3074	0.6568
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0258	0.3074	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0617	0.1035
Brugia malayi	Isocitrate dehydrogenase	0.005	0.0323	0.0537
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0058	0.0426	1
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.074	0.1577
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0043	0.0232	0.0241
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0139	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0266
Trichomonas vaginalis	guanylate cyclase, putative	0.0037	0.0152	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0348	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3074	0.5156
Entamoeba histolytica	hypothetical protein	0.0221	0.258	1
Brugia malayi	nuclear receptor RXR	0.0122	0.1272	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0122	0.1272	0.1367
Onchocerca volvulus		0.0105	0.1053	0.1613
Echinococcus multilocularis	regulator of G protein signaling 3	0.0038	0.0159	0.0159
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0258	0.3074	0.3303
Brugia malayi	hypoxia-induced factor 1	0.044	0.5474	0.9181
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0279	0.0325
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0038	0.0159	0.0335
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0137	0.1465	0.1465
Trypanosoma cruzi	target of rapamycin kinase 3	0.0047	0.028	0.1423
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0258	0.3074	0.5156
Echinococcus granulosus	intermediate filament protein	0.0053	0.0361	0.0387
Brugia malayi	PXA domain containing protein	0.0038	0.0159	0.0263
Echinococcus granulosus	aryl hydrocarbon receptor	0.0037	0.0152	0.0163
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0056	0.0401	0.0431
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0038	0.0159	0.0266
Loa Loa (eye worm)	hypothetical protein	0.008	0.0721	0.1209
Brugia malayi	Nuclear hormone receptor-like 1	0.0137	0.1465	0.2455
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0529	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0258	0.3074	0.3074
Echinococcus multilocularis	ecdysone induced protein 78C	0.0258	0.3074	0.3074
Brugia malayi	hypothetical protein	0.0122	0.1272	0.2131
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.0182	0.2137
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0405	0.5001	0.8388
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0122	0.1272	0.2716
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0043	0.0232	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0152	0.0254
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3074	0.5156
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0279	0.0325
Brugia malayi	Nuclear hormone receptor E75	0.0122	0.1272	0.2131
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0159	0.0335
Brugia malayi	nuclear receptor NHR-88	0.0122	0.1272	0.2131
Echinococcus multilocularis	GA binding protein alpha chain	0.0081	0.0737	0.0737
Schistosoma mansoni	cell polarity protein	0.005	0.0325	0.069
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0043	0.0232	0.1006
Onchocerca volvulus		0.0092	0.0884	0.131
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0159	0.0335
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0037	0.0152	0.031
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0037	0.0152	0.031
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0047	0.028	0.6514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0242	0.026
Loa Loa (eye worm)	hypothetical protein	0.005	0.0325	0.0545
Trichomonas vaginalis	adenylate cyclase, putative	0.0037	0.0152	0.0099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0242	0.026
Schistosoma mansoni	coup transcription factor	0.0258	0.3074	0.6568
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0242	0.026
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0258	0.3074	0.3074
Echinococcus granulosus	GPCR family 2	0.0033	0.0105	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1465	0.2458
Brugia malayi	conserved hypotetical protein	0.0122	0.1272	0.2131
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0529	0.0568
Brugia malayi	hypothetical protein	0.0221	0.258	0.4325
Schistosoma mansoni	z-protein (S1r protein)	0.0038	0.0159	0.0335
Onchocerca volvulus		0.0098	0.0955	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0529	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3074	0.5156
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.074	0.0795
Mycobacterium leprae	Possible regulatory protein	0.0037	0.0152	0.5
Echinococcus granulosus	mothers against decapentaplegic 5	0.0026	0.0002	0.0003
Loa Loa (eye worm)	hypoxia-induced factor 1	0.044	0.5474	0.9182
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.008	0.0721	0.1205
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0096	0.0001
Brugia malayi	intermediate filament protein	0.0053	0.0361	0.0601
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0988	0.2108
Brugia malayi	Ets-domain containing protein	0.0081	0.0737	0.1232
Schistosoma mansoni	lamin	0.0053	0.0361	0.0766
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0258	0.3074	0.5154
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3074	0.5156
Echinococcus multilocularis	geminin	0.0166	0.1849	0.1849
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Brugia malayi	EGF-like domain containing protein	0.005	0.0325	0.0542
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.2714	0.2916
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0122	0.1272	0.2006
Echinococcus granulosus	FTZ F1 alpha	0.0258	0.3074	0.3303
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0955	0.1601
Loa Loa (eye worm)	steroid hormone receptor	0.0258	0.3074	0.5156
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0058	0.0426	0.1202
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0122	0.1272	0.1272
Echinococcus multilocularis	axis inhibition protein axin	0.0038	0.0159	0.0159
Echinococcus multilocularis	thyroid hormone receptor alpha	0.038	0.4679	0.4679
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0037	0.0152	0.031
Onchocerca volvulus		0.0122	0.1272	0.2006
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0038	0.0159	0.0171
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0056	0.0402	0.1103
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.005	0.0323	0.6668
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0055	0.0395	0.0424
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0242	0.026
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0058	0.0429	1
Echinococcus granulosus	lamin	0.0053	0.0361	0.0387
Brugia malayi	photoreceptor-specific nuclear receptor	0.0258	0.3074	0.5154
Plasmodium vivax	SET domain protein, putative	0.0058	0.0429	1
Schistosoma mansoni	axis inhibition protein axin	0.0038	0.0159	0.0335
Brugia malayi	Pre-SET motif family protein	0.0058	0.0429	0.0716
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0038	0.0159	0.0263
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0429	0.0913
Echinococcus granulosus	expressed protein	0.0731	0.9307	1
Onchocerca volvulus		0.0258	0.3074	0.5229
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0132	0.0221
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.01	0.0988	0.1654
Brugia malayi	Nuclear hormone receptor-like 1	0.0137	0.1465	0.2455
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0132	0.0138
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0617	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3074	0.5156
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0069	0.0575	0.1224
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0152	0.0099
Schistosoma mansoni	thyroid hormone receptor	0.038	0.4679	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0132	0.0063
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0279	0.0325
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0058	0.0426	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0055	0.0395	0.0839
Echinococcus multilocularis	transfer RNA-Lys	0.0105	0.1053	0.1053
Brugia malayi	cytoplasmic intermediate filament protein	0.0028	0.0037	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0279	0.0325
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0258	0.3074	0.5154
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0258	0.3074	0.3074
Schistosoma mansoni	hypothetical protein	0.0033	0.0105	0.0219
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0159	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Brugia malayi	hypothetical protein	0.0137	0.1465	0.2455
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0043	0.0232	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.005	0.0323	0.6601
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0036	0.0139	0.0205
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0038	0.0159	0.0159
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0037	0.0152	0.0254
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0122	0.1272	0.2134
Schistosoma mansoni	nuclear receptor	0.0122	0.1272	0.2716
Onchocerca volvulus		0.0461	0.574	1
Brugia malayi	Pre-SET motif family protein	0.0405	0.5001	0.8388
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.005	0.0325	0.0542
Entamoeba histolytica	hypothetical protein	0.0221	0.258	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0133	0.0067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0258	0.3074	0.5156
Loa Loa (eye worm)	hypothetical protein	0.005	0.0325	0.0545
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0122	0.1272	0.1272
Brugia malayi	RNA binding protein	0.0066	0.0529	0.0883
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0037	0.0152	0.0099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.019	0.0167
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0037	0.0152	0.1155
Schistosoma mansoni	nuclear receptor nhr-48	0.0122	0.1272	0.2716
Loa Loa (eye worm)	hypothetical protein	0.0146	0.159	0.2667
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0037	0.0152	0.0099
Echinococcus multilocularis	regulator of G protein signaling 7	0.0038	0.0159	0.0159
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0132	0.0141
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0043	0.0232	0.0409
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0258	0.3074	0.5229
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0226	0.2645	0.2842
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0258	0.3074	0.6568
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0047	0.028	0.5296
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0061	0.0463	1
Schistosoma mansoni	ap endonuclease	0.0039	0.0182	0.0384
Brugia malayi	nuclear hormone receptor family member odr-7	0.0122	0.1272	0.2131
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0105	0.0105
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0182	0.0574
Schistosoma mansoni	hypothetical protein	0.0033	0.0105	0.0219
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0226	0.2646	0.4439
Loa Loa (eye worm)	RGS-3 protein	0.0038	0.0159	0.0266
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0132	0.0063
Brugia malayi	laminin alpha chain	0.005	0.0325	0.0542
Loa Loa (eye worm)	CYP4Cod1	0.0034	0.0116	0.0194
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0122	0.1272	0.2131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0242	0.026
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Brugia malayi	isocitrate dehydrogenase	0.005	0.0323	0.0537
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0132	0.0063
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0105	0.0105
Onchocerca volvulus	Bile acid receptor homolog	0.0258	0.3074	0.5229
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0038	0.0159	0.0263
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0159	0.0112
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.1058	0.1775
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0182	0.4174
Loa Loa (eye worm)	MH2 domain-containing protein	0.0026	0.0002	0.0004
Toxoplasma gondii	isocitrate dehydrogenase	0.005	0.0323	0.6415
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0096	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3074	0.5156
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0266
Loa Loa (eye worm)	hypothetical protein	0.007	0.0581	0.0974
Echinococcus multilocularis	nuclear receptor nhr 48	0.0122	0.1272	0.1272
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0105	0.0172
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.005	0.0323	0.0323
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0182	0.0574
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0529	0.1126
Brugia malayi	Cytochrome P450 family protein	0.0034	0.0116	0.019
Schistosoma mansoni	single-minded	0.0142	0.1541	0.329
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0043	0.0232	0.0409
Brugia malayi	nuclear receptor NHR-67	0.0122	0.1272	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0043	0.0232	0.5364
Schistosoma mansoni	axis inhibition protein axin	0.0038	0.0159	0.0335
Echinococcus granulosus	pikachurin	0.005	0.0325	0.0349
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0429	0.0913
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0258	0.3074	0.5154
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0258	0.3074	0.5156
Onchocerca volvulus	Protein ultraspiracle homolog	0.0258	0.3074	0.5229
Brugia malayi	M-phase phosphoprotein, mpp8	0.0098	0.0955	0.1598
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0029	0.0048	0.0985
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0058	0.0426	1
Echinococcus multilocularis	slit 2 protein	0.005	0.0325	0.0325
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0122	0.1272	0.2716
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.005	0.0323	0.0347
Schistosoma mansoni	ets-related	0.0247	0.2921	0.6241
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0028	0.0037	0.0062
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0529	0.0883
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0132	0.0132
Echinococcus granulosus	neurogenic locus notch protein	0.005	0.0325	0.0349
Loa Loa (eye worm)	Smad1	0.0026	0.0002	0.0004
Onchocerca volvulus		0.0053	0.0361	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Schistosoma mansoni	gabp alpha	0.0081	0.0737	0.157
Entamoeba histolytica	hypothetical protein	0.0038	0.0159	0.0111
Schistosoma mansoni	aryl hydrocarbon receptor	0.0142	0.1541	0.329
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0038	0.0159	0.0266
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.005	0.0323	0.5685
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0258	0.3074	0.6568
Trypanosoma brucei	cytochrome P450, putative	0.0034	0.0116	0.2591
Brugia malayi	Cytochrome P450 family protein	0.0036	0.0138	0.0227
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0286	0.0476
Brugia malayi	nuclear receptor RXR	0.0137	0.1465	0.2455
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.005	0.0323	0.7531
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0258	0.3074	0.3303
Brugia malayi	Nuclear hormone receptor E75	0.0122	0.1272	0.2131
Echinococcus multilocularis	neuropeptide receptor A26	0.0448	0.5578	0.5578
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0096	0.0001
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0055	0.0395	0.2978
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0182	0.5
Echinococcus granulosus	lysosomal alpha glucosidase	0.016	0.1773	0.1905
Echinococcus multilocularis	pikachurin	0.005	0.0325	0.0325
Brugia malayi	hypothetical protein	0.0477	0.5962	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0258	0.3074	0.3303
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0361	0.0601
Schistosoma mansoni	nuclear hormone receptor	0.0122	0.1272	0.2716
Echinococcus granulosus	regulator of G protein signaling 3	0.0038	0.0159	0.0171
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0258	0.3074	0.3303
Onchocerca volvulus		0.0047	0.0286	0.024
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0182	0.0182
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0258	0.3074	0.3074
Schistosoma mansoni	laminin gamma-3 chain	0.005	0.0325	0.069
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0055	0.0395	1
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Echinococcus multilocularis	lamin dm0	0.0053	0.0361	0.0361
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0105	0.0113
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.0721	0.0721
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0221	0.258	0.2772
Echinococcus granulosus	ecdysone induced protein 78C	0.0258	0.3074	0.3303
Brugia malayi	laminin-like protein K08C7.3 precursor	0.005	0.0325	0.0542
Brugia malayi	ecdysone receptor	0.0122	0.1272	0.2131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0138	0.0074
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0055	0.0395	0.2978
Leishmania major	protein kinase, putative	0.0037	0.0152	0.1155
Echinococcus granulosus	smad	0.0026	0.0002	0.0003
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0132	0.0138
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0058	0.0426	0.0426
Schistosoma mansoni	ap endonuclease	0.0039	0.0182	0.0384
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0122	0.1272	0.1272
Brugia malayi	hypothetical protein	0.0137	0.1465	0.2455
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0182	0.2763
Schistosoma mansoni	alpha glucosidase	0.0035	0.0132	0.0277
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0258	0.3074	0.5154
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0039	0.0182	0.0707
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0988	0.0988
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0175	0.014
Loa Loa (eye worm)	PXA domain-containing protein	0.0038	0.0159	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0159	0.0112
Echinococcus multilocularis	neuropeptide s receptor	0.0448	0.5578	0.5578
Brugia malayi	follicle stimulating hormone receptor	0.0226	0.2646	0.4436
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.005	0.0323	0.0685
Echinococcus granulosus	regulator of G protein signaling 7	0.0038	0.0159	0.0171
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0122	0.127	0.4651
Echinococcus multilocularis	Ankyrin repeat domain containing protein	0.0087	0.0809	0.0809
Brugia malayi	bHLH-PAS transcription factor	0.0105	0.1053	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0213	0.0358
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0258	0.3074	0.5156
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0122	0.1272	0.1272
Brugia malayi	nuclear hormone receptor	0.0122	0.1272	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1465	0.2458
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0361	0.0766
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0426	0.0585
Onchocerca volvulus		0.0098	0.0955	0.1437
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0071	0.0602	0.0647
Entamoeba histolytica	hypothetical protein	0.0038	0.0159	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3074	0.5156
Schistosoma mansoni	nuclear receptor	0.0122	0.1272	0.2716
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0105	0.0176
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0038	0.0159	0.0263
Echinococcus granulosus	axis inhibition protein axin	0.0038	0.0159	0.0171
Brugia malayi	Steroid receptor seven-up type 2	0.0258	0.3074	0.5154
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0038	0.0159	0.0112
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.005	0.0325	0.069
Echinococcus multilocularis	regulator of G protein signaling	0.0038	0.0159	0.0159
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.074	0.1238
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0038	0.0159	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0082	0.074	0.1241
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0122	0.1272	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0361	0.0605
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0096	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0242	0.026
Brugia malayi	steroid hormone receptor	0.0258	0.3074	0.5154
Echinococcus multilocularis	lysosomal alpha glucosidase	0.016	0.1773	0.1773
Schistosoma mansoni	multiple ankyrin repeats single kh domain protein	0.0087	0.0809	0.1726
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0122	0.127	0.2081
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0137	0.1465	0.3128
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0361	0.0605
Loa Loa (eye worm)	isocitrate dehydrogenase	0.005	0.0323	0.0541
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0258	0.3074	0.5154
Schistosoma mansoni	slit	0.005	0.0325	0.069
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0395	0.0659
Brugia malayi	hypothetical protein	0.012	0.125	0.2093
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.1058	0.1772
Schistosoma mansoni	hypothetical protein	0.0047	0.0286	0.0606
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.005	0.0323	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1272	0.2134
Echinococcus multilocularis	Smad4	0.0026	0.0002	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0988	0.1062
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0122	0.1272	0.1272
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.127	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.1058	0.1772
Loa Loa (eye worm)	hypothetical protein	0.012	0.125	0.2096
Schistosoma mansoni	hypothetical protein	0.0221	0.258	0.5511
Loa Loa (eye worm)	phosphatidylinositol 3	0.0058	0.0426	0.0714
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0426	0.0585
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0529	0.0887
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0242	0.026
Echinococcus multilocularis	FTZ F1 alpha	0.0258	0.3074	0.3074
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0266
Brugia malayi	PAS domain containing protein	0.0142	0.1541	0.2582
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0258	0.3074	0.5154
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0266
Echinococcus multilocularis	regulator of G protein signaling 3	0.0038	0.0159	0.0159
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0055	0.0395	0.9
Brugia malayi	regulator of G-protein signaling rgs-7	0.0038	0.0159	0.0263

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3010 nM	Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay	ChEMBL.	21332118
Ki (binding)	= 18 nM	Inhibition of human PI3Kalpha expressed in Sf9 cells	ChEMBL.	21332118

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1773559

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1560984