Detailed information for compound 1563100

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 597.024 | Formula: C32H28ClF3N2O4
  • H donors: 2 H acceptors: 4 LogP: 7.36 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CCNC(=O)c1ccc(cc1)C[C@@H](C(=O)c1cc2c(n1c1cccc(c1)C(F)(F)F)ccc(c2)Cl)CC1CC1
  • InChi: 1S/C32H28ClF3N2O4/c33-25-10-11-27-22(16-25)17-28(38(27)26-3-1-2-24(18-26)32(34,35)36)30(41)23(14-19-4-5-19)15-20-6-8-21(9-7-20)31(42)37-13-12-29(39)40/h1-3,6-11,16-19,23H,4-5,12-15H2,(H,37,42)(H,39,40)/t23-/m0/s1
  • InChiKey: YOFHXKXENHFFJZ-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon receptor 477 aa 457 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus protein jagged 2 0.0016 0.0029 0.0035
Echinococcus multilocularis protein dispatched 1 0.005 0.0433 0.0433
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0156 0.0676
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Echinococcus multilocularis slit 2 protein 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Loa Loa (eye worm) hypothetical protein 0.0024 0.0126 0.019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Onchocerca volvulus 0.0018 0.0052 0.0376
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0216 0.0267
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.01 0.1046 0.1577
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0039 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0358 0.3527
Onchocerca volvulus 0.0016 0.0029 0.0206
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.0216 0.206
Toxoplasma gondii PAN/Apple domain-containing protein 0.0018 0.0052 0.0078
Loa Loa (eye worm) hypothetical protein 0.0123 0.1324 0.1997
Loa Loa (eye worm) Notch2 0.0016 0.0029 0.0043
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.011 0.1175 0.1175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0373 0.186
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.1039 0.5181
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0448 0.0675
Onchocerca volvulus 0.0128 0.1389 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0000000099439 0.00000001228
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0216 0.0267
Mycobacterium ulcerans chitinase/cellulase 0.0066 0.0632 0.3174
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.1063 0.4989
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0132
Loa Loa (eye worm) Ulp1 protease 0.0095 0.0985 0.1485
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0314 0.3067
Echinococcus granulosus neural cadherin 0.0016 0.0029 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0126 0.0521
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0434 0.0434
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0448 0.0675
Loa Loa (eye worm) hypothetical protein 0.0043 0.0358 0.054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0189 0.0189
Trichomonas vaginalis Sentrin-specific protease, putative 0.0095 0.0985 1
Brugia malayi bZIP transcription factor family protein 0.0081 0.0818 0.1233
Mycobacterium leprae putative cytochrome p450 0.0016 0.0027 0.005
Echinococcus multilocularis expressed conserved protein 0.0139 0.1519 0.1519
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0173 0.1934 0.5325
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.004 0.0314 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0023 0.0023
Entamoeba histolytica aldose reductase, putative 0.0032 0.0216 0.0482
Echinococcus granulosus slit 2 protein 0.0016 0.0029 0.0035
Onchocerca volvulus 0.0016 0.0029 0.0206
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0189 0.0285
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0052 0.0079
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0027 0.0033
Loa Loa (eye worm) hypothetical protein 0.0101 0.1063 0.1603
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0707 0.0873
Brugia malayi latrophilin 2 splice variant baaae 0.0123 0.1334 0.2011
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3617 1
Schistosoma mansoni notch 0.0016 0.0029 0.0143
Schistosoma mansoni hypothetical protein 0.0066 0.0632 0.3154
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Schistosoma mansoni slit 0.0016 0.0029 0.0143
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0285
Schistosoma mansoni notch 0.0016 0.0029 0.0143
Onchocerca volvulus 0.0018 0.0052 0.0376
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Schistosoma mansoni nuclear hormone receptor 0.003 0.0189 0.0943
Echinococcus granulosus neurogenic locus notch protein 4 0.0016 0.0029 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0189 0.0285
Loa Loa (eye worm) hypothetical protein 0.0024 0.0126 0.019
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0189 0.0285
Brugia malayi endochitinase 0.0077 0.0771 0.1162
Schistosoma mansoni cell polarity protein 0.0016 0.0029 0.0143
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0285
Echinococcus multilocularis aldo keto reductase 0.0032 0.0216 0.0216
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0216 0.0326
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0189 0.0233
Brugia malayi EGF-like domain containing protein 0.0016 0.0029 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1621 0.4457
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0028 0.003
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Trypanosoma cruzi aldo/keto reductase, putative 0.0032 0.0216 0.0554
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0314 0.0473
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0122 0.1317 0.1986
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Leishmania major delta-5 fatty acid desaturase 0.01 0.1046 0.2858
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Giardia lamblia Sentrin specific protease, putative 0.004 0.0314 0.7036
Onchocerca volvulus 0.0051 0.0448 0.3224
Echinococcus multilocularis aldo keto reductase 0.0032 0.0216 0.0216
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0189 0.0943
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Echinococcus granulosus single minded 2 0.0048 0.0415 0.0513
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0314 0.0473
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0189 0.0233
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0314 0.3067
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0314 0.1001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0189 0.0285
Entamoeba histolytica aldose reductase, putative 0.0032 0.0216 0.0482
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0057 0.0525 0.0525
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0434 0.1159
Echinococcus multilocularis GPCR, family 2 0.0057 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0067 0.0651 0.0651
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0126 0.0521
Loa Loa (eye worm) hypothetical protein 0.0123 0.1324 0.1997
Schistosoma mansoni notch 0.0017 0.003 0.015
Echinococcus granulosus aldo keto reductase 0.0032 0.0216 0.0267
Schistosoma mansoni laminin gamma-3 chain 0.0016 0.0029 0.0143
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0358 0.054
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0067 0.0651 0.6545
Echinococcus granulosus tumor protein p63 0.0678 0.8098 1
Plasmodium vivax sentrin-specific protease 2, putative 0.004 0.0314 0.1398
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0189 0.0189
Echinococcus multilocularis mitogen activated protein kinase 14 0.0122 0.1317 0.1317
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0028 0.003
Brugia malayi Peroxidasin 0.0051 0.0448 0.0675
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Echinococcus multilocularis Ankyrin 0.0014 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0107 0.1133 0.5358
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.003 0.0216
Schistosoma mansoni hypothetical protein 0.0042 0.0339 0.1693
Onchocerca volvulus 0.01 0.105 0.7557
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0216 0.0267
Echinococcus multilocularis sentrin specific protease 8 0.0095 0.0985 0.0985
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0189 0.0943
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0448 0.0675
Loa Loa (eye worm) notch protein 0.0016 0.0029 0.0043
Brugia malayi nuclear receptor NHR-88 0.003 0.0189 0.0285
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0189 0.0233
Loa Loa (eye worm) hypothetical protein 0.004 0.0314 0.0473
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0067 0.0651 0.0803
Echinococcus granulosus protein jagged 1 0.0016 0.0029 0.0035
Toxoplasma gondii microneme protein, putative 0.0018 0.0052 0.0078
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0016 0.0029 0.0206
Giardia lamblia Aldose reductase 0.0032 0.0216 0.4632
Trypanosoma cruzi aldo-keto reductase 0.0032 0.0216 0.0554
Onchocerca volvulus 0.0032 0.0216 0.1558
Onchocerca volvulus Chorion peroxidase homolog 0.0051 0.0448 0.3224
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Echinococcus multilocularis sentrin specific protease 7 0.0178 0.2005 0.2005
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0434 0.1159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0189 0.0285
Schistosoma mansoni hypothetical protein 0.0107 0.1133 0.565
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0189 0.0943
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0079
Onchocerca volvulus 0.0032 0.0216 0.1558
Loa Loa (eye worm) hypothetical protein 0.0039 0.03 0.0452
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Toxoplasma gondii PAN domain-containing protein 0.0285 0.3304 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0126 0.0568
Onchocerca volvulus Putative endochitinase 0.0087 0.0884 0.6367
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Schistosoma mansoni jun-related protein 0.0066 0.0632 0.3154
Brugia malayi hypothetical protein 0.0015 0.0017 0.0026
Echinococcus granulosus jun protein 0.0081 0.0818 0.101
Loa Loa (eye worm) hypothetical protein 0.0057 0.0525 0.0792
Trypanosoma cruzi SUMO1/Ulp2, putative 0.004 0.0314 0.0825
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Loa Loa (eye worm) hypothetical protein 0.0053 0.0478 0.072
Echinococcus granulosus FTZ F1 alpha 0.003 0.0189 0.0233
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0029 0.0043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0189 0.0189
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0434 0.4309
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0079
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0173 0.1934 0.5325
Leishmania major aldo-keto reductase-like protein 0.0032 0.0216 0.0554
Schistosoma mansoni hypothetical protein 0.0057 0.0525 0.262
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0126 0.0521
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.004 0.0314 0.0877
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0001 0.0007
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0052 0.0079
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.1083 0.5399
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.004 0.0314 0.0877
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0079
Loa Loa (eye worm) hypothetical protein 0.0181 0.2031 0.3062
Echinococcus granulosus GPCR family 2 0.0057 0.0525 0.0649
Loa Loa (eye worm) microfilarial chitinase 0.0075 0.0746 0.1124
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0019 0.0023
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0173 0.1934 0.5325
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0039 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0126 0.0521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0039 0.0063
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0126 0.0521
Echinococcus multilocularis mitogen activated protein kinase 11 0.0122 0.1317 0.1317
Plasmodium falciparum conserved protein, unknown function 0.0123 0.1324 0.6763
Brugia malayi Endochitinase 0.0087 0.0884 0.1333
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0651 0.6545
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0051 0.0127
Plasmodium vivax hypothetical protein, conserved 0.0123 0.1324 0.6763
Onchocerca volvulus 0.0016 0.0029 0.0206
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0189 0.0285
Echinococcus multilocularis protein patched 0.0043 0.0358 0.0358
Toxoplasma gondii hypothetical protein 0.0123 0.1324 0.396
Brugia malayi cytochrome P450 0.0016 0.0027 0.004
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.0216 0.206
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0076
Onchocerca volvulus 0.0051 0.0448 0.3224
Onchocerca volvulus Putative endochitinase 0.0077 0.0771 0.5549
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0216 0.0326
Echinococcus multilocularis protein jagged 1 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0189 0.0285
Echinococcus multilocularis jun protein 0.0081 0.0818 0.0818
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0448 0.3224
Onchocerca volvulus 0.0018 0.0052 0.0376
Schistosoma mansoni hypothetical protein 0.0042 0.0339 0.1693
Brugia malayi Zinc finger, C2H2 type family protein 0.0067 0.0651 0.0981
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0173 0.1934 0.2916
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0079
Echinococcus granulosus delta-like protein 1 0.0016 0.0029 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Entamoeba histolytica hypothetical protein 0.0107 0.1133 0.5358
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.1133 0.1399
Echinococcus multilocularis notch 0.0016 0.0029 0.0029
Onchocerca volvulus 0.0018 0.0052 0.0376
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0358 0.0443
Toxoplasma gondii EGF family domain-containing protein 0.0016 0.0029 0.0006
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0434 0.0536
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0651 0.6545
Loa Loa (eye worm) hypothetical protein 0.0113 0.1207 0.1819
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0052 0.0079
Brugia malayi hypothetical protein 0.0064 0.0605 0.0913
Loa Loa (eye worm) hypothetical protein 0.0079 0.0791 0.1192
Schistosoma mansoni hypothetical protein 0.0057 0.0525 0.262
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0651 0.6545
Echinococcus multilocularis aldo keto reductase 0.0032 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Entamoeba histolytica hypothetical protein 0.0107 0.1133 0.5358
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0128 0.1389 0.2094
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0028 0.003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0189 0.0285
Schistosoma mansoni hypothetical protein 0.0042 0.0339 0.1693
Schistosoma mansoni retinoic acid receptor RXR 0.0126 0.1365 0.6808
Echinococcus multilocularis fibropellin Ia 0.0016 0.0029 0.0029
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0372 0.0372
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0373 0.046
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0123 0.1324 0.1997
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0285
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0143
Onchocerca volvulus Putative cubilin 0.0016 0.0029 0.0206
Brugia malayi CHE-14 protein 0.0043 0.0358 0.054
Brugia malayi GCC2 and GCC3 family protein 0.0016 0.0029 0.0043
Loa Loa (eye worm) oxidoreductase 0.0032 0.0216 0.0326
Loa Loa (eye worm) hypothetical protein 0.0558 0.6633 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0032 0.0216 0.0554
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0189 0.0943
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0189 0.0285
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.0104 0.0454
Mycobacterium ulcerans hypothetical protein 0.0164 0.1824 0.9423
Schistosoma mansoni hypothetical protein 0.0057 0.0525 0.262
Schistosoma mansoni patched 1 0.0043 0.0358 0.1788
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0126 0.0302
Onchocerca volvulus 0.0123 0.1324 0.9535
Echinococcus granulosus Ankyrin 0.0014 0.0001 0.0002
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Schistosoma mansoni hypothetical protein 0.0057 0.0525 0.262
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0143
Schistosoma mansoni thyroid hormone receptor 0.003 0.0189 0.0943
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0189 0.0285
Toxoplasma gondii microneme protein MIC17C 0.0018 0.0052 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0079
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0095 0.0985 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0189 0.0285
Schistosoma mansoni aldo-keto reductase 0.0032 0.0216 0.108
Brugia malayi hypothetical protein 0.0016 0.0019 0.0029
Onchocerca volvulus 0.0016 0.0029 0.0206
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.1063 0.1603
Loa Loa (eye worm) oxidoreductase 0.0032 0.0216 0.0326
Schistosoma mansoni pol-related 0.0032 0.0216 0.108
Toxoplasma gondii microneme protein MIC17B 0.0018 0.0052 0.0078
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0314 0.0473
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.0029 0.0029
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0019 0.0095
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0373 0.0562
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0314 0.3067
Brugia malayi Cytochrome P450 family protein 0.0027 0.0156 0.0234
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0448 0.0675
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0189 0.0285
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0314 0.1001
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0173 0.1934 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0448 0.0675
Echinococcus multilocularis fat cadherin tumor suppressor 0.0016 0.0029 0.0029
Brugia malayi Cadherin domain containing protein 0.0016 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.0113 0.1201 0.181
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0028 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0373 0.0562
Brugia malayi endochitinase 0.0087 0.0884 0.1333
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0434 0.1135
Onchocerca volvulus Putative endochitinase 0.0087 0.0884 0.6367
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.1133 0.1133
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0651 0.6545
Onchocerca volvulus 0.0032 0.0216 0.1558
Loa Loa (eye worm) oxidoreductase 0.0032 0.0216 0.0326
Schistosoma mansoni notch 0.0016 0.0029 0.0143
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0189 0.0285
Echinococcus granulosus peroxidasin 0.0051 0.0448 0.0553
Brugia malayi hypothetical protein 0.0051 0.0448 0.0675
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0173 0.1934 0.2916
Leishmania major dihydroorotate dehydrogenase 0.0173 0.1934 0.5325
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.1063 0.1063
Onchocerca volvulus 0.0018 0.0052 0.0376
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0052 0.0079
Echinococcus multilocularis sentrin specific protease 1 0.004 0.0314 0.0314
Echinococcus multilocularis mitogen activated protein kinase 14 0.0122 0.1317 0.1317
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.004 0.0314 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0122 0.1317 0.1317
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0448 0.0675
Toxoplasma gondii PAN domain-containing protein 0.0018 0.0052 0.0078
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0095 0.0985 0.4573
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Schistosoma mansoni septate junction protein 0.0016 0.0029 0.0143
Leishmania major cytochrome p450-like protein 0.0016 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0285
Toxoplasma gondii PAN domain-containing protein 0.0285 0.3304 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0373 0.046
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0361 0.0932
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Brugia malayi Cytochrome P450 family protein 0.0027 0.0156 0.0234
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0314 0.3067
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0434 0.4309
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0029
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0216 0.0267
Echinococcus granulosus aldo keto reductase 0.0032 0.0216 0.0267
Brugia malayi Delta serrate ligand family protein 0.0016 0.0029 0.0043
Brugia malayi EGF-like domain containing protein 0.0016 0.0029 0.0043
Echinococcus granulosus mitogen activated protein kinase 11 0.0122 0.1317 0.1627
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0126 0.0302
Brugia malayi Muscle positioning protein 4 0.0016 0.0029 0.0043
Mycobacterium ulcerans putative regulatory protein 0.0044 0.0365 0.1776
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0448 0.3224
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0173 0.1934 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0076
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0448 0.0675
Toxoplasma gondii aldose reductase, putative 0.0032 0.0216 0.058
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0285
Mycobacterium tuberculosis Possible chitinase 0.0066 0.0632 0.3174
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0067 0.0651 0.0651
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0126 0.019
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0173 0.1934 1
Schistosoma mansoni single-minded 0.0059 0.0554 0.2763
Schistosoma mansoni thyroid hormone receptor 0.003 0.0189 0.0943
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.0029 0.0029
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0113 0.1201 0.181
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0019 0.0019
Loa Loa (eye worm) oxidoreductase 0.0032 0.0216 0.0326
Brugia malayi hypothetical protein 0.0016 0.0019 0.0029
Brugia malayi small heat shock protein 0.0558 0.6633 1
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.1133 0.565
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0123 0.1324 0.1324
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0478 0.128
Plasmodium vivax sentrin-specific protease 1, putative 0.004 0.0314 0.1398
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.004 0.0314 0.0825
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0216 0.0267
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0057 0.0525 0.0649
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0818 0.0818
Schistosoma mansoni peroxidasin 0.0051 0.0448 0.2234
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0358 0.0443
Onchocerca volvulus 0.0045 0.0372 0.2675
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0434 0.1244
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.0029 0.0029
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0189 0.0285
Loa Loa (eye worm) hypothetical protein 0.0024 0.0126 0.019
Echinococcus granulosus mitogen activated protein kinase 14 0.0122 0.1317 0.1627
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.0029 0.0035
Brugia malayi Cytochrome P450 family protein 0.0039 0.0307 0.0464
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0216 0.0326
Onchocerca volvulus 0.0018 0.0052 0.0376
Onchocerca volvulus 0.0123 0.1324 0.9535
Toxoplasma gondii PAN domain-containing protein 0.0018 0.0052 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0189 0.0285
Brugia malayi MAP kinase sur-1 0.005 0.0434 0.0655
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0434 0.1159
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.1593 0.1968
Brugia malayi Latrophilin receptor protein 2 0.0057 0.0525 0.0792
Toxoplasma gondii subtilisin SUB12 0.0018 0.0052 0.0078
Loa Loa (eye worm) PAN domain-containing protein 0.0018 0.0052 0.0079
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Onchocerca volvulus Putative endochitinase 0.0077 0.0771 0.5549
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0434 0.0536
Echinococcus granulosus expressed conserved protein 0.0095 0.0989 0.1221
Brugia malayi Delta5 fatty acid desaturase 0.01 0.1046 0.1577
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1621 0.4457
Schistosoma mansoni aldo-keto reductase 0.0032 0.0216 0.108
Trypanosoma brucei prostaglandin f synthase 0.0032 0.0216 0.0529
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Schistosoma mansoni coup transcription factor 0.003 0.0189 0.0943
Echinococcus multilocularis peroxidasin 0.0051 0.0448 0.0448
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0016 0.0023 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0373 0.186
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0189 0.0285
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0095 0.0985 0.4913
Echinococcus multilocularis 0.0016 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0107 0.1133 0.5358
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0178 0.2005 1
Trypanosoma brucei SUMO1/Ulp2, putative 0.004 0.0314 0.0801
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0422 0.2103
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0000000099439 0.0000000099439
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0122 0.1317 0.3612
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0019 0.0029
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.1593 0.1593
Plasmodium falciparum dihydroorotate dehydrogenase 0.0173 0.1934 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1039 0.1566
Onchocerca volvulus Peroxidase homolog 0.0051 0.0448 0.3224
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0067 0.0651 0.0803
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0216 0.0267
Schistosoma mansoni dihydroorotate dehydrogenase 0.0173 0.1934 0.9646
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0707 0.0707
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0189 0.0285
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0156 0.0234
Loa Loa (eye worm) cytochrome P450 0.0016 0.0027 0.004
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0067 0.0651 0.176
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0434 0.1159
Onchocerca volvulus 0.0032 0.0216 0.1558
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0178 0.2005 1
Onchocerca volvulus 0.0024 0.0126 0.0906
Loa Loa (eye worm) hypothetical protein 0.0066 0.0632 0.0953
Echinococcus multilocularis aldehyde reductase 0.0023 0.0104 0.0104
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Echinococcus granulosus protein jagged 2 0.0016 0.0029 0.0035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0057 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0095 0.0985 1
Trypanosoma brucei aldo-keto reductase, putative 0.0032 0.0216 0.0529
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Loa Loa (eye worm) oxidoreductase 0.0032 0.0216 0.0326
Echinococcus granulosus sentrin specific protease 1 0.004 0.0314 0.0388
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0122 0.1317 0.3595
Brugia malayi Uncoordinated protein 44 0.0014 0.0000000099439 0.000000014992
Loa Loa (eye worm) hypothetical protein 0.004 0.0314 0.0473
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.004 0.0314 0.3067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0189 0.0233
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0434 0.0655
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0336 0.3294
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0019 0.0029
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0122 0.1317 0.3612
Onchocerca volvulus 0.0099 0.1039 0.7479
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0126 0.019
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0372 0.056
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0095 0.0985 1
Loa Loa (eye worm) FAT-3 protein 0.01 0.1046 0.1577
Leishmania major chitinase 0.0077 0.0771 0.2094
Brugia malayi Calcitonin receptor-like protein seb-1 0.0181 0.2031 0.3062
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0029 0.0043
Schistosoma mansoni hypothetical protein 0.0123 0.1324 0.6606
Leishmania major prostaglandin f synthase, putative 0.0032 0.0216 0.0554
Loa Loa (eye worm) hypothetical protein 0.0032 0.0216 0.0326
Onchocerca volvulus 0.003 0.0189 0.1361
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.0027 0.005
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0156 0.0385
Echinococcus multilocularis neurogenic locus notch protein 4 0.0016 0.0029 0.0029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0126 0.1365 0.1686
Brugia malayi bHLH-PAS transcription factor 0.0044 0.0365 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0189 0.0285
Brugia malayi EGF-like domain containing protein 0.0016 0.0029 0.0043
Entamoeba histolytica chitinase, putative 0.0077 0.0771 0.3432
Brugia malayi Cadherin domain containing protein 0.0016 0.0029 0.0043
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0189 0.0233
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0314 0.3067
Entamoeba histolytica aldose reductase, putative 0.0032 0.0216 0.0482
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0126 0.0521
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0057 0.0525 0.0792
Loa Loa (eye worm) Ulp1 protease 0.004 0.0314 0.0473
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0189 0.0943
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.3617 1
Mycobacterium ulcerans oxidoreductase 0.0032 0.0216 0.0996
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0216 0.0267
Toxoplasma gondii PAN domain-containing protein 0.0018 0.0052 0.0078
Loa Loa (eye worm) hypothetical protein 0.004 0.0314 0.0473
Echinococcus granulosus aldo keto reductase 0.0032 0.0216 0.0267
Onchocerca volvulus 0.0032 0.0216 0.1558
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0016 0.0029 0.0143
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0434 0.1159
Schistosoma mansoni notch 0.0016 0.0029 0.0143
Mycobacterium ulcerans hypothetical protein 0.0024 0.0126 0.0521
Echinococcus multilocularis aldo keto reductase 0.0032 0.0216 0.0216
Onchocerca volvulus Dual oxidase homolog 0.0051 0.0448 0.3224
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0189 0.0285
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0173 0.1934 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0189 0.0943
Echinococcus granulosus protein jagged 1 0.0016 0.0029 0.0035
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0143
Brugia malayi notch-like transmembrane receptor 0.0016 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0361 0.0956
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0361 0.0956
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0051 0.1134
Brugia malayi Death domain containing protein 0.0014 0.0000000099439 0.000000014992
Onchocerca volvulus 0.0032 0.0216 0.1558
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0434 0.1159
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0032 0.0216 0.0554
Leishmania major protein kinase, putative 0.0022 0.01 0.0229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0189 0.0189
Onchocerca volvulus 0.004 0.0314 0.226
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0189 0.1361
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0189 0.0233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0373 0.186
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0126 0.0568
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0181 0.2031 0.3062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0189 0.0943
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0285
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Brugia malayi P38 map kinase family protein 2 0.0122 0.1317 0.1986
Schistosoma mansoni fatty acid desaturase 0.01 0.105 0.5236
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0372 0.0459
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.004 0.0314 0.0877
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0126 0.0521
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0216 0.0267
Echinococcus multilocularis aryl hydrocarbon receptor 0.0128 0.1395 0.1395
Toxoplasma gondii PAN domain-containing protein 0.0018 0.0052 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1824 0.9423
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0029 0.0043
Onchocerca volvulus 0.0018 0.0052 0.0376
Giardia lamblia Aldose reductase 0.0032 0.0216 0.4632
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Echinococcus multilocularis protein jagged 2 0.0016 0.0029 0.0029
Loa Loa (eye worm) chitinase I 0.0077 0.0771 0.1162
Schistosoma mansoni hypothetical protein 0.0123 0.1334 0.6653
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0189 0.1361
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0143
Onchocerca volvulus 0.0064 0.0605 0.4358
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0434 0.0434
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0361 0.0956
Leishmania major protein kinase, putative 0.0016 0.0028 0.003
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0336 0.3294
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0189 0.0285
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.004 0.0314 0.1566
Schistosoma mansoni cytochrome P450 0.0016 0.0027 0.0132
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.0216 0.206
Loa Loa (eye worm) hypothetical protein 0.009 0.0924 0.1393
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0143
Brugia malayi Blistered cuticle protein 3 0.0051 0.0448 0.0675
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0314 0.1001
Echinococcus multilocularis tumor protein p63 0.0678 0.8098 0.8098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0076
Toxoplasma gondii hypothetical protein 0.005 0.044 0.126
Echinococcus multilocularis neural cadherin 0.0016 0.0029 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0189 0.0285
Echinococcus multilocularis protein jagged 1 0.0016 0.0029 0.0029
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1621 0.4442
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0143
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0076
Echinococcus granulosus sentrin specific protease 7 0.0178 0.2005 0.2476
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0189 0.0189
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0126 0.0521
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0314 0.1001
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0189 0.0189
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Echinococcus multilocularis transfer RNA-Lys 0.0044 0.0365 0.0365
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0448 0.0675
Onchocerca volvulus Peroxidase homolog 0.0051 0.0448 0.3224
Schistosoma mansoni aryl hydrocarbon receptor 0.0173 0.1932 0.9637
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0027 0.0026
Onchocerca volvulus 0.0018 0.0052 0.0376
Onchocerca volvulus 0.0018 0.0052 0.0376
Echinococcus granulosus sentrin specific protease 8 0.0095 0.0985 0.1217
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0057 0.0525 0.0792
Toxoplasma gondii microneme protein MIC4 0.0018 0.0052 0.0078
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.3617 1
Brugia malayi steroid hormone receptor 0.003 0.0189 0.0285
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.004 0.0314 0.1566
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0051 0.0127
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0123 0.1324 0.1636
Loa Loa (eye worm) cuticular endochitinase 0.0077 0.0771 0.1162
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.0216 0.206
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0189 0.0233
Leishmania major cytochrome p450-like protein 0.0027 0.0156 0.0385
Echinococcus granulosus neurogenic locus protein delta 0.0016 0.0029 0.0035
Brugia malayi EGF-like domain containing protein 0.0016 0.0029 0.0043
Schistosoma mansoni notch 0.0016 0.0029 0.0143
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0189 0.0189
Echinococcus granulosus aldehyde reductase 0.0023 0.0104 0.0129
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0173 0.1934 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0651 0.6545
Onchocerca volvulus Putative endochitinase 0.0087 0.0884 0.6367
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0372 0.056
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0285
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0818 0.101
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3617 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0189 0.0285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0373 0.0373
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0027 0.0026
Brugia malayi ecdysteroid receptor 0.003 0.0189 0.0285
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0156 0.0385
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Echinococcus granulosus notch 0.0016 0.0029 0.0035
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0067 0.0651 0.2793
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0216 0.0267
Brugia malayi Cytochrome P450 family protein 0.0016 0.0027 0.004
Brugia malayi nuclear hormone receptor 0.003 0.0189 0.0285
Leishmania major cytochrome p450-like protein 0.0016 0.0027 0.0026
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0314 0.3067
Mycobacterium ulcerans chitinase/cellulase 0.0066 0.0632 0.3174
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0422 0.2103
Onchocerca volvulus 0.0051 0.0448 0.3224
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0018 0.0052 0.0078
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0156 0.0359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0373 0.0373
Onchocerca volvulus Slit protein homolog 0.0016 0.0029 0.0206
Brugia malayi EGF-like domain containing protein 0.0016 0.0029 0.0043
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0434 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0314 0.3067
Schistosoma mansoni hypothetical protein 0.0042 0.0339 0.1693
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0156 0.0234
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0189 0.0285
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0434 0.4309
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.0029 0.0035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0189 0.0943
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0019 0.0095
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0122 0.1317 0.3612
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0156 0.0234
Onchocerca volvulus 0.0016 0.0029 0.0206
Brugia malayi PAS domain containing protein 0.0059 0.0554 0.0835
Toxoplasma gondii hypothetical protein 0.0018 0.0052 0.0078
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0000000099439 0.000000049597
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0307 0.0464
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0039 0.0063
Loa Loa (eye worm) hypothetical protein 0.0123 0.1334 0.2011
Brugia malayi hypothetical protein 0.0107 0.1133 0.1708
Echinococcus granulosus aryl hydrocarbon receptor 0.0128 0.1395 0.1723
Plasmodium falciparum sentrin-specific protease 1 0.004 0.0314 0.1398
Echinococcus granulosus expressed conserved protein 0.0139 0.1519 0.1876
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0448 0.0675
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0434 0.4309
Brugia malayi Protein kinase domain containing protein 0.0015 0.0011 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0189 0.0285
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0032 0.0216 0.104
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0189 0.0189
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0173 0.1934 0.5313
Brugia malayi nuclear receptor RXR 0.0016 0.0019 0.0029
Trypanosoma cruzi hypothetical protein 0.0095 0.0985 0.2689
Toxoplasma gondii microneme protein MIC17A 0.0018 0.0052 0.0078
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0216 0.0326
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0126 0.0302
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0126 0.0521
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0189 0.1361
Loa Loa (eye worm) hypothetical protein 0.0051 0.0448 0.0675
Echinococcus granulosus hypothetical protein 0.0032 0.0216 0.0267
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0029
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.1063 0.1313
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 0.0216 0.0996
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0285
Schistosoma mansoni peroxidasin 0.0051 0.0448 0.2234
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0023 0.0029
Brugia malayi EGF-like domain containing protein 0.0016 0.0029 0.0043
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0057 0.0525 0.0649
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.0216 0.206
Trypanosoma brucei protein kinase, putative 0.005 0.0434 0.1135
Brugia malayi PAN domain containing protein 0.0018 0.0052 0.0079
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.0216 0.206
Onchocerca volvulus 0.0018 0.0052 0.0376
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0216 0.0216
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0189 0.0189
Echinococcus multilocularis expressed conserved protein 0.0095 0.0989 0.0989
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0434 0.2166
Echinococcus granulosus fibropellin Ia 0.0016 0.0029 0.0035
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0016 0.0029 0.0043
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0095 0.0985 0.1485
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Brugia malayi EGF-like domain containing protein 0.0016 0.0029 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0181 0.2031 0.3062
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0173 0.1934 0.582
Onchocerca volvulus 0.0018 0.0052 0.0376
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0126 0.019
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.004 0.0314 0.0825
Loa Loa (eye worm) blistered cuticle protein 3 0.0051 0.0448 0.0675
Toxoplasma gondii hypothetical protein 0.0018 0.0052 0.0078
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0216 0.206
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0079

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 37 nM Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay ChEMBL. 22030028
IC50 (functional) = 55 nM Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubated for 30 mins before glucagon challenge measured after 30 mins using [125I]-cAMP by liquid scintillation counting ChEMBL. 22030028

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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