Detailed information for compound 1575395

Basic information

Technical information
  • TDR Targets ID: 1575395
  • Name: 2-[[6-[(4-ethoxyphenyl)methyl]-5-oxo-2H-1,2,4 -triazin-3-yl]sulfanyl]-N-phenylacetamide
  • MW: 396.463 | Formula: C20H20N4O3S
  • H donors: 2 H acceptors: 5 LogP: 3.22 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)Cc1nnc(nc1O)SCC(=O)Nc1ccccc1
  • InChi: 1S/C20H20N4O3S/c1-2-27-16-10-8-14(9-11-16)12-17-19(26)22-20(24-23-17)28-13-18(25)21-15-6-4-3-5-7-15/h3-11H,2,12-13H2,1H3,(H,21,25)(H,22,24,26)
  • InChiKey: JBNCXJAEFRJOMH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[6-[(4-ethoxyphenyl)methyl]-5-oxo-2H-1,2,4-triazin-3-yl]sulfanyl]-N-phenyl-acetamide
  • 2-[[6-[(4-ethoxyphenyl)methyl]-5-oxo-2H-1,2,4-triazin-3-yl]thio]-N-phenylacetamide
  • 2-[[6-(4-ethoxybenzyl)-5-keto-2H-1,2,4-triazin-3-yl]thio]-N-phenyl-acetamide
  • 2-[[6-[(4-ethoxyphenyl)methyl]-5-oxo-2H-1,2,4-triazin-3-yl]sulfanyl]-N-phenyl-ethanamide
  • ZINC04317290

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0038 0.0064
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0074 0.0071
Plasmodium falciparum flap endonuclease 1 0.0025 0.0175 0.3716
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0544 0.0993
Echinococcus granulosus Large neutral amino acids transporter small 0.0026 0.0181 0.0178
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0907 0.0904
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0084 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0074 0.011
Onchocerca volvulus 0.023 0.3297 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0076 0.1032
Brugia malayi hypothetical protein 0.0019 0.0082 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0074 0.011
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0337 0.3964
Echinococcus granulosus intestinal type alkaline phosphatase 0.0527 0.7822 0.7821
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0527 0.7822 0.7821
Brugia malayi Cathepsin L-like precursor 0.0016 0.0038 0.0098
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0041 0.0408 0.1137
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0038 0.0106
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0214 0.2947
Entamoeba histolytica hypothetical protein 0.0019 0.0074 0.2049
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0053 0.0152
Leishmania major GTP-binding protein, putative 0.0026 0.0181 0.2463
Loa Loa (eye worm) ctsf protein 0.0016 0.0038 0.0064
Echinococcus multilocularis cationic amino acid transporter 0.0026 0.0181 0.0178
Schistosoma mansoni hypothetical protein 0.0274 0.3964 0.3962
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0347 0.0344
Onchocerca volvulus 0.0016 0.0038 0.0106
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0219 0.0217
Echinococcus multilocularis thyroid hormone receptor alpha 0.03 0.4369 0.4367
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0544 0.1554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0074 0.0071
Schistosoma mansoni single-minded 0.0051 0.0571 0.0568
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0221 0.0561
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.088 0.0877
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0074 0.0071
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0181 0.5048
Brugia malayi nuclear receptor RXR 0.0019 0.0084 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0074 0.011
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0347 0.1045
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0006 0.0083
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0214 0.0211
Echinococcus multilocularis peregrin 0.0028 0.0219 0.0217
Schistosoma mansoni hypothetical protein 0.0264 0.3812 0.381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Schistosoma mansoni hypothetical protein 0.0372 0.5455 0.5454
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Onchocerca volvulus 0.0017 0.0053 0.0152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0347 0.0344
Schistosoma mansoni lipoxygenase 0.0019 0.0082 0.0079
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0347 0.0344
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0145 0.258
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0347 0.0344
Echinococcus granulosus tar DNA binding protein 0.0061 0.0723 0.072
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0082 0.1554
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0076 0.1032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0064
Onchocerca volvulus 0.0038 0.0368 0.1109
Schistosoma mansoni inositol monophosphatase 0.0036 0.0337 0.0334
Brugia malayi Amino acid permease family protein 0.0026 0.0181 0.0498
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0347 0.096
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0081 0.0078
Brugia malayi hypothetical protein 0.0019 0.0084 0.0227
Echinococcus multilocularis cysteine protease 0.0016 0.0038 0.0035
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0076 0.2107
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0175 0.3149
Schistosoma mansoni serine-rich repeat protein 0.0097 0.1269 0.1267
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.3587 0.3585
Onchocerca volvulus 0.0016 0.0038 0.0106
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0252 0.2679
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0397
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.031 0.0563
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0544 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0347 0.0344
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0074 0.0071
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0368 0.0365
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0723 0.072
Echinococcus granulosus geminin 0.0168 0.2347 0.2345
Brugia malayi TAR-binding protein 0.0061 0.0723 0.2009
Echinococcus granulosus yl amino acid transporter 2 0.0026 0.0181 0.0178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0347 0.0631
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0175 0.0173
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0532 0.7248
Schistosoma mansoni DNA helicase recq1 0.0028 0.0214 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Schistosoma mansoni thyroid hormone receptor 0.03 0.4369 0.4367
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0723 0.132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0232 0.0229
Echinococcus granulosus alkaline phosphatase 0.0527 0.7822 0.7821
Schistosoma mansoni ran 0.0026 0.0181 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Schistosoma mansoni cationic amino acid transporter 0.0026 0.0181 0.0178
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0347 0.0344
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0723 0.072
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0232 0.0229
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0005 0.0002
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0038 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0544 0.1554
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0027 0.0206 0.0517
Toxoplasma gondii PUL domain-containing protein 0.0041 0.0408 0.7473
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0544 0.1554
Entamoeba histolytica hypothetical protein 0.0026 0.0194 0.5674
Loa Loa (eye worm) inositol-1 0.0036 0.0337 0.0612
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0337 0.4586
Loa Loa (eye worm) hypothetical protein 0.0037 0.0347 0.0631
Onchocerca volvulus Alhambra homolog 0.0028 0.0219 0.0657
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0347 0.0344
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0053 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0347 0.0631
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0053 0.005
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0413 0.6088 0.6087
Loa Loa (eye worm) RecQ helicase 0.004 0.0399 0.0727
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0252 0.3434
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0527 0.7822 0.7821
Brugia malayi RNA binding protein 0.0061 0.0723 0.2009
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0074 0.0071
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0053 0.005
Schistosoma mansoni rab6-interacting 0.0019 0.0082 0.0079
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0337 0.0917
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0084 0.0227
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0082 0.0079
Leishmania major cathepsin L-like protease 0.0016 0.0038 0.0517
Echinococcus granulosus cationic amino acid transporter 0.0024 0.0152 0.0149
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0074 0.0071
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0175 0.213
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0347 0.0344
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0149
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0053 0.0139
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0347 0.0344
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Brugia malayi Amino acid permease family protein 0.0026 0.0181 0.0498
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0734 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.1058 0.1935
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0388 0.0385
Brugia malayi Cathepsin L-like precursor 0.0016 0.0038 0.0098
Brugia malayi nuclear receptor NHR-67 0.0017 0.0053 0.0139
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0347 0.0344
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0074 0.0071
Trypanosoma brucei WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0027 0.0206 0.1985
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0337 0.0917
Brugia malayi hypothetical protein 0.0019 0.0074 0.0198
Echinococcus granulosus single minded 2 0.0038 0.0368 0.0365
Echinococcus multilocularis RUN 0.0019 0.0082 0.0079
Schistosoma mansoni thyroid hormone receptor 0.03 0.4369 0.4367
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0074 0.0071
Onchocerca volvulus 0.0016 0.0038 0.0106
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.031 0.0307
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0219 0.3966
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0544 0.1554
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0003
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0053 0.0139
Brugia malayi hypoxia-induced factor 1 0.0159 0.2207 0.6151
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0175 0.2391
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0076 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0347 0.0631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Schistosoma mansoni loxhd1 0.0019 0.0082 0.0079
Echinococcus multilocularis microtubule associated protein 2 0.067 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0053 0.005
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0081 0.0143
Brugia malayi nuclear hormone receptor 0.0017 0.0053 0.0139
Loa Loa (eye worm) WD domain-containing protein 0.0027 0.0206 0.0373
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0264 0.3812 0.381
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0232 0.0229
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0347 0.0631
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0527 0.7822 0.7821
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0347 0.0631
Schistosoma mansoni polycystin 1-related 0.0019 0.0082 0.0079
Schistosoma mansoni importin beta-1 0.0035 0.0321 0.0318
Entamoeba histolytica hypothetical protein 0.0028 0.0221 0.6486
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0347 0.096
Leishmania major cathepsin L-like protease 0.0016 0.0038 0.0517
Brugia malayi WD domain containing protein 0.0041 0.0408 0.1131
Entamoeba histolytica hypothetical protein 0.0019 0.0074 0.2049
Loa Loa (eye worm) hypothetical protein 0.0037 0.0347 0.0631
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.031 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0347 0.0344
Giardia lamblia PHD finger protein 15 0.0028 0.0219 0.3068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.241 0.4415
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0347 0.0344
Schistosoma mansoni zinc finger protein 0.0017 0.0053 0.005
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0544 0.0541
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0084 0.0081
Brugia malayi Flap endonuclease-1 0.0025 0.0175 0.0482
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0321 0.3724
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0347 0.0344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0191 0.0346
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0081 0.0078
Leishmania major hypothetical protein, conserved 0.0041 0.0408 0.556
Echinococcus granulosus voltage dependent calcium channel subunit 0.0188 0.2654 0.2652
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0544 0.0541
Brugia malayi PHD-finger family protein 0.0028 0.0219 0.0604
Brugia malayi hypothetical protein 0.0019 0.0082 0.022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0347 0.096
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0221 0.0561
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0347 0.096
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0337 0.4586
Brugia malayi hypothetical protein 0.0172 0.241 0.6718
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0038 0.0035
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0544 0.7412
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0347 0.0344
Loa Loa (eye worm) cysteine protease 0.0016 0.0038 0.0064
Leishmania major cathepsin L-like protease 0.0062 0.0734 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0723 0.132
Schistosoma mansoni alkaline phosphatase 0.0527 0.7822 0.7821
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.5455 1
Schistosoma mansoni hypothetical protein 0.0058 0.0677 0.0674
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0074 0.0198
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0214 0.4749
Brugia malayi ecdysone receptor 0.0017 0.0053 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0149
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0337 0.5
Echinococcus granulosus voltage dependent calcium channel subunit 0.0413 0.6088 0.6087
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0337 0.8921
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0347 0.096
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0181 0.2463
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0082 0.0079
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.013
Leishmania major cathepsin L-like protease 0.0062 0.0734 1
Echinococcus granulosus Ankyrin 0.0014 0.0005 0.0002
Schistosoma mansoni microtubule-associated protein tau 0.067 1 1
Schistosoma mansoni hypothetical protein 0.0097 0.1269 0.1267
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0175 0.0317
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0279 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0219 0.0217
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0003 0.000000030841
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0214 0.0211
Echinococcus multilocularis amino acid permease 0.0026 0.0181 0.0178
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0175 0.4862
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0183 0.018
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0544 0.0541
Schistosoma mansoni survival motor neuron protein 0.0051 0.0565 0.0562
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0053 0.005
Schistosoma mansoni DNA polymerase eta 0.0019 0.0076 0.0073
Echinococcus multilocularis snurportin 1 0.0372 0.5455 0.5454
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0053 0.005
Loa Loa (eye worm) hypoxia-induced factor 1 0.0159 0.2207 0.4043
Entamoeba histolytica recQ family helicase, putative 0.003 0.0252 0.7442
Echinococcus granulosus snurportin 1 0.0372 0.5455 0.5454
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0544 0.7412
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0081 0.0078
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0232 0.0229
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0181 0.0178
Echinococcus multilocularis amino acids transporter 0.0026 0.0181 0.0178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0145
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0214 0.0211
Echinococcus granulosus peregrin 0.0028 0.0219 0.0217
Brugia malayi hypothetical protein 0.0019 0.0084 0.0227
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0076 0.0134
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0038 0.0517
Brugia malayi Cathepsin L-like precursor 0.0016 0.0038 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0347 0.096
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0221 0.3004
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0053 0.005
Onchocerca volvulus 0.0017 0.0053 0.0152
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0337 0.0334
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0053 0.005
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0053 0.0152
Brugia malayi conserved hypotetical protein 0.0017 0.0053 0.0139
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0053 0.0092
Brugia malayi hypothetical protein 0.0017 0.0053 0.0139
Schistosoma mansoni nuclear receptor 0.0017 0.0053 0.005
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0038 0.0035
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0038 0.0963
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0076 0.0203
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0734 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0076 0.0203
Echinococcus multilocularis cationic amino acid transporter 0.0024 0.0152 0.0149
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0076 0.0073
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0074 0.0071
Brugia malayi steroid hormone receptor 0.0037 0.0347 0.096
Brugia malayi Death domain containing protein 0.0014 0.0003 0.000000086036
Loa Loa (eye worm) DR-78 0.0017 0.0053 0.0092
Echinococcus multilocularis geminin 0.0168 0.2347 0.2345
Loa Loa (eye worm) amino acid permease 0.0026 0.0181 0.0327
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0149
Brugia malayi hypothetical protein 0.0249 0.3587 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0723 0.072
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0544 0.0541
Loa Loa (eye worm) RNA binding protein 0.0061 0.0723 0.132
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0544 0.7412
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0214 0.0211
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0037 0.0361 0.8721
Schistosoma mansoni hypothetical protein 0.0019 0.0082 0.0079
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0053 0.005
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0074 0.0071
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0053 0.005
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0181 0.1595
Schistosoma mansoni inositol monophosphatase 0.0036 0.0337 0.0334
Schistosoma mansoni flap endonuclease-1 0.0023 0.0138 0.0136
Plasmodium falciparum phd finger protein, putative 0.0028 0.0219 0.4903
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0038 0.0106
Schistosoma mansoni cationic amino acid transporter 0.0026 0.0181 0.0178
Schistosoma mansoni cationic amino acid transporter 0.0026 0.0181 0.0178
Plasmodium falciparum polyubiquitin binding protein, putative 0.0041 0.0408 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0038 0.0035
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0527 0.7822 0.7821
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0074 0.0071
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0214 0.0387
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0053 0.0139
Brugia malayi Cathepsin L-like precursor 0.0016 0.0038 0.0098
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.018 0.2537 0.2535
Schistosoma mansoni cationic amino acid transporter 0.0026 0.0181 0.0178
Schistosoma mansoni phospholipase A-2-activating protein 0.0027 0.0206 0.0204
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0074 0.013
Schistosoma mansoni ran 0.0026 0.0181 0.0178
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0252 0.3434
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0347 0.096
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0347 0.0344
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0038 0.0098
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0399 0.1106
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0347 0.096
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0074 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0347 0.0631
Brugia malayi Uncoordinated protein 44 0.0014 0.0003 0.000000086036
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0544 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0038 0.0064
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0053 0.005
Echinococcus granulosus cathepsin l1 0.0016 0.0038 0.0035
Echinococcus multilocularis expressed protein 0.0362 0.5313 0.5311
Brugia malayi jmjC domain containing protein 0.0034 0.031 0.0856
Onchocerca volvulus 0.0016 0.0038 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0081 0.0078
Echinococcus multilocularis bloom syndrome protein 0.004 0.0399 0.0396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0074 0.0198
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0264 0.3812 0.381
Brugia malayi Pre-SET motif family protein 0.0029 0.0232 0.0639
Plasmodium vivax importin-beta 2, putative 0.0035 0.0321 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0347 0.0344
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0149
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.031 0.0307
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0723 0.072
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0074 0.0071
Leishmania major cathepsin L-like protease 0.0016 0.0038 0.0517
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0368 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0232 0.0229
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0232 0.4197
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0175 0.1515
Leishmania major cathepsin L-like protease 0.0062 0.0734 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0347 0.0344
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0149
Entamoeba histolytica hypothetical protein 0.0019 0.0074 0.2049
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0091 0.1175 0.1173
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.042
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0347 0.1045
Brugia malayi tailless protein 0.0017 0.0053 0.0139
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0388 0.0385
Schistosoma mansoni hypothetical protein 0.0168 0.2347 0.2345
Loa Loa (eye worm) hypothetical protein 0.0027 0.0206 0.0373
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0082 0.0079
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.1196 0.1193
Loa Loa (eye worm) amino acid permease 0.0026 0.0181 0.0327
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0076 0.0073
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0038 0.0035
Brugia malayi Importin beta-1 subunit 0.0035 0.0321 0.0887
Brugia malayi Inositol-1 0.0036 0.0337 0.0931
Schistosoma mansoni hypothetical protein 0.0028 0.0219 0.0217
Loa Loa (eye worm) hypothetical protein 0.0028 0.0214 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0723 0.072
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0076 0.0116
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0214 0.0588
Onchocerca volvulus 0.0019 0.0082 0.024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0076 0.0134
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0337 0.6145
Brugia malayi MAP kinase sur-1 0.0049 0.0544 0.151
Onchocerca volvulus 0.0051 0.0565 0.1705
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0188 0.2654 0.2652
Onchocerca volvulus 0.0016 0.0038 0.0106
Loa Loa (eye worm) hypothetical protein 0.0048 0.0526 0.096
Onchocerca volvulus 0.0019 0.0082 0.024
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0544 0.7412
Brugia malayi jmjC domain containing protein 0.0092 0.1196 0.3329
Brugia malayi Pre-SET motif family protein 0.0202 0.2869 0.7999
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0076 0.0116
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0216 0.0213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0145
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0038 0.0517
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0074 0.0071
Echinococcus granulosus cationic amino acid transporter 0.0026 0.0181 0.0178
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.031 0.0307
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0074 0.0198
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.0037 0.0347 0.0631
Echinococcus multilocularis cationic amino acid transporter 0.0026 0.0181 0.0178
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0321 0.5851
Onchocerca volvulus 0.0037 0.0347 0.1045
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0347 0.096
Brugia malayi Doublecortin family protein 0.0019 0.0082 0.022
Brugia malayi PXA domain containing protein 0.0019 0.0074 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0232 0.0229
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0214 0.0588
Onchocerca volvulus 0.0016 0.0038 0.0106
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0175 0.2391
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0053 0.005
Leishmania major importin beta-1 subunit, putative 0.0028 0.0221 0.3004
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0038 0.0035
Echinococcus granulosus importin subunit beta 1 0.0035 0.0321 0.0318
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0081 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0347 0.096
Trichomonas vaginalis ran, putative 0.0026 0.0181 0.0439
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0347 0.0344
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0038 0.0035
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0181 0.2463
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0076 0.1032
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0232 0.0229
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0544 0.7114
Onchocerca volvulus 0.0016 0.0038 0.0106
Echinococcus multilocularis Large neutral amino acids transporter small 0.0026 0.0181 0.0178
Brugia malayi Cathepsin L-like precursor 0.0016 0.0038 0.0098
Brugia malayi ecdysteroid receptor 0.0037 0.0347 0.096
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0347 0.0344
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0347 0.0344
Echinococcus granulosus dna polymerase kappa 0.0019 0.0076 0.0073
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0076 0.1032
Loa Loa (eye worm) hypothetical protein 0.0249 0.3587 0.6573
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.3587 0.3585
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0038 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0347 0.0344
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0214 0.386
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0347 0.0344
Brugia malayi nuclear receptor RXR 0.0017 0.0053 0.0139
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0074 0.0071
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0003 0.000000030841
Leishmania major DNA polymerase eta, putative 0.0019 0.0076 0.1032
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0181 0.0326
Echinococcus multilocularis dna polymerase eta 0.0019 0.0076 0.0073
Trypanosoma brucei protein kinase, putative 0.0049 0.0544 0.7114
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0347 0.096
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0607 0.0604
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0565 0.1567
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0082 0.0079
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0175 0.0422
Brugia malayi hypothetical protein 0.0019 0.0074 0.0198
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0074 0.013
Echinococcus granulosus amino acids transporter 0.0026 0.0181 0.0178
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0082 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0347 0.096
Loa Loa (eye worm) fibroinase 0.0016 0.0038 0.0064
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0279 0.5
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0399 0.1109
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.013
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0321 0.0318
Echinococcus granulosus phospholipase A 2 activating protein 0.0041 0.0408 0.0405
Trichomonas vaginalis DNA helicase recq, putative 0.003 0.0252 0.0658
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0053 0.005
Brugia malayi PAS domain containing protein 0.0051 0.0571 0.1586
Leishmania major cathepsin L-like protease 0.0016 0.0038 0.0517
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0053 0.0139
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0347 0.0344
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0074 0.0198
Echinococcus multilocularis phospholipase A 2 activating protein 0.0041 0.0408 0.0405
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0053 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0347 0.096
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0084 0.0149
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0544 0.7412
Brugia malayi Cathepsin L-like precursor 0.0016 0.0038 0.0098
Loa Loa (eye worm) hypothetical protein 0.0037 0.0347 0.0631
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0347 0.1045
Brugia malayi hypothetical protein 0.0118 0.1591 0.4432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.013
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0219 0.0397
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0041 0.0408 0.556
Plasmodium vivax SET domain protein, putative 0.0029 0.0232 0.6854
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0074 0.011
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0723 0.072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0181 0.3858
Schistosoma mansoni hypothetical protein 0.0168 0.2347 0.2345
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0544 0.0541
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0219 0.0217
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0181 0.2243
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0347 0.096
Echinococcus multilocularis Large neutral amino acids transporter small 0.0026 0.0181 0.0178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0053 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0038 0.0963
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0347 0.0631
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0074 0.0071
Schistosoma mansoni coup transcription factor 0.0037 0.0347 0.0344
Loa Loa (eye worm) hypothetical protein 0.0308 0.4484 0.8218
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0175 0.5125
Echinococcus granulosus RUN 0.0019 0.0082 0.0079
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0652 0.8884
Treponema pallidum ATP-dependent DNA helicase 0.0014 0.0006 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0321 0.0583
Entamoeba histolytica Ran family GTPase 0.0026 0.0181 0.5284
Loa Loa (eye worm) hypothetical protein 0.0037 0.0347 0.0631
Plasmodium falciparum importin beta, putative 0.0035 0.0321 0.7643
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0321 0.3724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Echinococcus granulosus bloom syndrome protein 0.004 0.0399 0.0396
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0076 0.0073
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0084 0.0081
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0074 0.0071
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0074 0.011
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0337 0.0334
Leishmania major cathepsin L-like protease 0.0016 0.0038 0.0517
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0074 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0347 0.0344
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0053 0.0139
Schistosoma mansoni nuclear receptor 0.0017 0.0053 0.005
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0074 0.0071
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0153 0.4071
Echinococcus granulosus 5'partial|cationic amino acid transporter 0.0024 0.0152 0.0149
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0081 0.0078
Echinococcus granulosus expressed protein 0.0362 0.5313 0.5311
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0074 0.0071
Echinococcus multilocularis cationic amino acid transporter 0.0026 0.0181 0.0178
Echinococcus multilocularis cysteine protease 0.0016 0.0038 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0347 0.0631
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0347 0.096
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0082 0.1188
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0347 0.0344
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0571 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0074 0.011
Brugia malayi nuclear hormone receptor 0.0037 0.0347 0.096
Echinococcus granulosus dna polymerase eta 0.0019 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Schistosoma mansoni blooms syndrome DNA helicase 0.0014 0.0006 0.0003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0006 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0219 0.6415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0347 0.0631
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0181 0.3247
Echinococcus multilocularis alkaline phosphatase 0.0527 0.7822 0.7821
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0181 0.0178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0076 0.1032
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0676 0.1235
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0037 0.0347 0.0631
Brugia malayi nuclear receptor NHR-88 0.0037 0.0347 0.096
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0003 0.000000030841
Brugia malayi Bromodomain containing protein 0.0028 0.0219 0.0604
Schistosoma mansoni rab6-interacting 0.0019 0.0082 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0734 1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0734 1
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0347 0.0344
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0082 0.0079
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0038 0.0106
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0041 0.0408 0.556
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0053 0.0139
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0081 0.0143
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0399 0.1109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0221 0.0561
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0074 0.0198
Schistosoma mansoni hypothetical protein 0.0051 0.0565 0.0562
Brugia malayi Protein kinase domain containing protein 0.0014 0.001 0.0019
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0544 0.7412
Brugia malayi Cache domain containing protein 0.0083 0.1058 0.2945
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.1196 0.1193
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0347 0.096
Echinococcus granulosus flap endonuclease 1 0.0025 0.0175 0.0173
Loa Loa (eye worm) hypothetical protein 0.0037 0.0347 0.0631
Schistosoma mansoni alkaline phosphatase 0.0527 0.7822 0.7821
Trichomonas vaginalis set domain proteins, putative 0.023 0.3295 1
Echinococcus multilocularis Ankyrin 0.0014 0.0005 0.0002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0214 0.386
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.088 0.0877
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2869 0.5257
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0219 0.3966
Brugia malayi RNA, U transporter 1 0.0099 0.1299 0.3617
Onchocerca volvulus 0.0029 0.0232 0.0695
Schistosoma mansoni DNA helicase recq5 0.0028 0.0214 0.0211
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0337 0.4586
Echinococcus multilocularis y+l amino acid transporter 2 0.0026 0.0181 0.0178
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0337 0.0917
Onchocerca volvulus 0.0026 0.0181 0.0542
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0723 0.2009
Entamoeba histolytica cysteine protease, putative 0.0016 0.0038 0.0963
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0076 0.1032
Brugia malayi nuclear receptor NHR-88 0.0017 0.0053 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.013
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0607 0.0604
Brugia malayi hypothetical protein 0.0017 0.0053 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0074 0.011
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0084 0.0081
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0053 0.0092
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0084 0.0227
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0074 0.0071
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0076 0.1032
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0074 0.0071
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0181 0.0496
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0074 0.0071
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0074 0.013
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0074 0.0071
Schistosoma mansoni lipoxygenase 0.0054 0.0607 0.0604
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0347 0.0344
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0734 1
Entamoeba histolytica amino acid permease, putative 0.0026 0.0181 0.5302
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0074 0.0071
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0527 0.7822 0.7821
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0368 0.1019
Brugia malayi PXA domain containing protein 0.0019 0.0074 0.0198
Toxoplasma gondii cathepsin CPL 0.0016 0.0038 0.0592
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0053 0.005

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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