TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 350.38 | Formula: C13H13F3N2O2S2
H donors: 0 H acceptors: 1 LogP: 3.75 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CSCCn1/c(=N/C(=O)C)/sc2c1ccc(c2)OC(F)(F)F
InChi: 1S/C13H13F3N2O2S2/c1-8(19)17-12-18(5-6-21-2)10-4-3-9(7-11(10)22-12)20-13(14,15)16/h3-4,7H,5-6H2,1-2H3/b17-12-
InChiKey: YNHUZZMRMVQKER-ATVHPVEESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	epidermal growth factor receptor	0.0092	0.2469	0.2447
Echinococcus multilocularis	titin	0.0156	0.5375	0.5361
Echinococcus granulosus	peroxidasin	0.0069	0.1408	0.1382
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0162	0.5653	0.5782
Schistosoma mansoni	titin	0.0063	0.113	0.1177
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Schistosoma mansoni	cell adhesion molecule	0.0069	0.1408	0.1472
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0062	0.1085	0.1058
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0091	0.2434	1
Schistosoma mansoni	myosin-binding protein-related	0.0154	0.5295	0.5602
Schistosoma mansoni	cell adhesion molecule	0.0154	0.5295	0.5602
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0091	0.2434	0.2472
Loa Loa (eye worm)	hypothetical protein	0.016	0.5573	0.57
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Entamoeba histolytica	protein kinase, putative	0.0062	0.1085	1
Brugia malayi	hypothetical protein	0.0091	0.2434	0.4141
Schistosoma mansoni	cell adhesion molecule	0.0063	0.113	0.1177
Echinococcus multilocularis	titin	0.0063	0.113	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0154	0.5295	0.5414
Echinococcus multilocularis	epidermal growth factor receptor	0.0092	0.2469	0.2447
Echinococcus granulosus	cell adhesion molecule	0.0091	0.2434	0.2411
Echinococcus multilocularis	titin	0.0091	0.2434	0.2411
Echinococcus granulosus	tyrosine protein kinase HCK	0.0062	0.1085	0.1058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.5295	0.907
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0252	0.9755	0.9754
Brugia malayi	Tyrosine-protein kinase abl-1	0.0127	0.4059	0.6942
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0091	0.2434	0.2411
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0039	0.003	0.0272
Onchocerca volvulus		0.0091	0.2434	0.4498
Onchocerca volvulus		0.0154	0.5295	0.9851
Onchocerca volvulus		0.0063	0.113	0.2058
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Echinococcus granulosus	tyrosine kinase	0.0069	0.1404	0.1379
Onchocerca volvulus		0.0063	0.113	0.2058
Brugia malayi	Lethal protein 805	0.0091	0.2434	0.4141
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0076	0.1716	0.1691
Echinococcus multilocularis	anosmin 1	0.0091	0.2434	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Brugia malayi	Protein kinase domain containing protein	0.0166	0.5835	1
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0069	0.1408	0.1472
Echinococcus multilocularis	plexin a4	0.0041	0.0142	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0046	0.0341	0.0312
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.1408	0.1417
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0094	0.2571	0.2549
Schistosoma mansoni	tyrosine kinase	0.0046	0.0341	0.0339
Echinococcus multilocularis	roundabout 2	0.0179	0.6426	0.6415
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Echinococcus multilocularis	neuroglian	0.016	0.5573	0.556
Schistosoma mansoni	tyrosine kinase	0.0166	0.5835	0.6175
Brugia malayi	plexin A	0.0041	0.0142	0.0194
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0063	0.113	0.1895
Echinococcus granulosus	titin	0.0156	0.5375	0.5361
Brugia malayi	Prion-like-	0.0063	0.113	0.1895
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0076	0.1716	0.1691
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.5295	0.5414
Schistosoma mansoni	titin	0.0091	0.2434	0.2562
Loa Loa (eye worm)	TK protein kinase	0.0094	0.2571	0.2614
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0091	0.2434	0.2472
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0094	0.2571	0.4378
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Onchocerca volvulus		0.0154	0.5295	0.9851
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0729	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0051	0.0592	0.0564
Echinococcus granulosus	twitchin	0.0083	0.2062	0.2039
Schistosoma mansoni	tyrosine kinase	0.0092	0.2469	0.26
Schistosoma mansoni	tyrosine kinase	0.0061	0.1027	0.1068
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0054	0.0729	0.0743
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0729	0.0743
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0051	0.0592	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0076	0.1716	0.1691
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Loa Loa (eye worm)	TK/ROR protein kinase	0.0094	0.2571	0.2614
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0076	0.1716	0.1691
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2261	0.2294
Echinococcus granulosus	titin	0.0063	0.113	0.1103
Schistosoma mansoni	tyrosine kinase	0.0092	0.2469	0.26
Onchocerca volvulus	Peroxidasin homolog	0.0063	0.113	0.2058
Onchocerca volvulus	Peroxidasin homolog	0.0063	0.113	0.2058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.5295	0.907
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0729	0.0743
Loa Loa (eye worm)	disorganized muscle protein 1	0.0063	0.113	0.1131
Echinococcus multilocularis		0.0063	0.113	0.1103
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0063	0.113	0.1895
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.016	0.5573	0.5897
Echinococcus granulosus	neuroglian	0.0082	0.1983	0.1959
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0252	0.9755	0.9754
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0076	0.1716	0.1691
Giardia lamblia	Kinase, CMGC MAPK	0.0054	0.0729	1
Schistosoma mansoni	titin	0.0063	0.113	0.1177
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0069	0.1404	0.1379
Schistosoma mansoni	titin	0.0154	0.5295	0.5602
Onchocerca volvulus	Netrin receptor homolog	0.0063	0.113	0.2058
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0054	0.0729	0.0743
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.016	0.5573	0.556
Echinococcus multilocularis	down syndrome cell adhesion	0.0063	0.113	0.1103
Schistosoma mansoni	septate junction protein	0.0069	0.1408	0.1472
Onchocerca volvulus		0.0091	0.2434	0.4498
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0063	0.113	0.1103
Onchocerca volvulus		0.0091	0.2434	0.4498
Onchocerca volvulus		0.0063	0.113	0.2058
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0091	0.2434	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0076	0.1716	0.1691
Echinococcus multilocularis	roundabout 2	0.016	0.5573	0.556
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Onchocerca volvulus		0.0063	0.113	0.2058
Schistosoma mansoni	hypothetical protein	0.0063	0.113	0.1177
Schistosoma mansoni	nephrin	0.0173	0.6148	0.6508
Onchocerca volvulus		0.0156	0.5375	1
Brugia malayi	Leucine Rich Repeat family protein	0.0063	0.113	0.1895
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0076	0.1716	0.1691
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0098	0.2712	0.462
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1408	0.1417
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.1408	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Loa Loa (eye worm)	CAMK protein kinase	0.0156	0.5375	0.5496
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0051	0.0592	0.0564
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0076	0.1716	0.1691
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.0729	0.0701
Schistosoma mansoni	cell adhesion molecule	0.0154	0.5295	0.5602
Echinococcus multilocularis	anosmin 1	0.0091	0.2434	0.2411
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0076	0.1716	0.1691
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0258	1	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.3429	0.3495
Leishmania major	hypothetical protein, conserved	0.0091	0.2434	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0091	0.2434	0.4141
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0051	0.0592	0.0578
Echinococcus granulosus	c src tyrosine kinase	0.0046	0.0341	0.0312
Echinococcus granulosus	Fibronectin type III	0.0091	0.2434	0.2411
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.0729	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.1408	0.2374
Echinococcus multilocularis	Fibronectin, type III	0.0091	0.2434	0.2411
Echinococcus granulosus	anosmin 1	0.0091	0.2434	0.2411
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0054	0.0729	0.0743
Brugia malayi	Prion-like-	0.0069	0.1408	0.2374
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1634	0.165
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2261	0.2294
Schistosoma mansoni	titin	0.0063	0.113	0.1177
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0063	0.113	0.1103
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0091	0.2434	0.2411
Schistosoma mansoni	septate junction protein	0.0069	0.1408	0.1472
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0092	0.2469	0.2447
Echinococcus multilocularis	cell adhesion molecule	0.0091	0.2434	0.2411
Echinococcus granulosus	roundabout 2	0.016	0.5573	0.556
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.1408	0.2374
Loa Loa (eye worm)	hypothetical protein	0.011	0.3287	0.3349
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0729	1
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0729	1
Brugia malayi	Fibronectin type III domain containing protein	0.0091	0.2434	0.4141
Trypanosoma cruzi	hypothetical protein, conserved	0.0091	0.2434	1
Onchocerca volvulus		0.0091	0.2434	0.4498
Echinococcus granulosus	epidermal growth factor receptor	0.0092	0.2469	0.2447
Onchocerca volvulus	Tyrosine kinase homolog	0.0094	0.2571	0.4755
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.016	0.5573	0.556
Echinococcus multilocularis	insulin receptor	0.0166	0.5835	0.5822
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0098	0.2712	0.269
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0091	0.2434	0.2411
Echinococcus multilocularis	roundabout 2	0.016	0.5573	0.556
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0156	0.5375	0.5496
Echinococcus granulosus	Netrin receptor DCC	0.0091	0.2434	0.2411
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0056	0.0841	0.0835
Trypanosoma brucei	protein kinase, putative	0.0054	0.0729	0.0743
Schistosoma mansoni	tyrosine kinase	0.0061	0.1027	0.1068
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0046	0.0341	0.0339
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0091	0.2434	0.2411
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0091	0.2434	0.2411
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0091	0.2434	1
Onchocerca volvulus		0.0063	0.113	0.2058
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0069	0.1408	0.1382
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0076	0.1716	0.1691
Echinococcus granulosus	titin	0.0156	0.5375	0.5361
Echinococcus multilocularis	insulin growth factor binding	0.0063	0.113	0.1103
Schistosoma mansoni	hypothetical protein	0.0091	0.2434	0.2562
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.113	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Brugia malayi	myotactin form B	0.0091	0.2434	0.4141
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0051	0.0592	0.0606
Schistosoma mansoni	titin	0.0069	0.1408	0.1472
Schistosoma mansoni	factor for adipocyte differentiation	0.0091	0.2434	0.2562
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1408	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Brugia malayi	SPRY domain containing protein	0.0091	0.2434	0.4141
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.1408	0.2374
Echinococcus multilocularis	tyrosine protein kinase otk	0.0069	0.1408	0.1382
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0076	0.1716	0.1691
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0094	0.2571	0.2549
Schistosoma mansoni	hypothetical protein	0.0063	0.113	0.1177
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Schistosoma mansoni	protein tyrosine phosphatase	0.0091	0.2434	0.2562
Loa Loa (eye worm)	hypothetical protein	0.0154	0.5295	0.5414
Echinococcus granulosus	contactin	0.016	0.5573	0.556
Schistosoma mansoni	hypothetical protein	0.0091	0.2434	0.2562
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.1408	0.2374
Loa Loa (eye worm)	SRC-1	0.0076	0.1716	0.1734
Echinococcus granulosus	usherin	0.0091	0.2434	0.2411
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0156	0.5375	0.9207
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.5295	0.5414
Echinococcus multilocularis	lachesin	0.0069	0.1408	0.1382
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0127	0.4059	0.4042
Brugia malayi	Peroxidasin	0.0069	0.1408	0.2374
Loa Loa (eye worm)	TK protein kinase	0.0062	0.1085	0.1085
Echinococcus granulosus	lachesin	0.0069	0.1408	0.1382
Onchocerca volvulus		0.0063	0.113	0.2058
Onchocerca volvulus		0.0091	0.2434	0.4498
Brugia malayi	Lethal protein 805	0.0091	0.2434	0.4141
Echinococcus multilocularis	titin	0.0063	0.113	0.1103
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0091	0.2434	0.2411
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0091	0.2434	0.2562
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0069	0.1404	0.1379
Schistosoma mansoni	roundabout	0.0069	0.1408	0.1472
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0091	0.2434	1
Brugia malayi	Fibronectin type III domain containing protein	0.0091	0.2434	0.4141
Brugia malayi	kettin	0.0063	0.113	0.1895
Onchocerca volvulus		0.0091	0.2434	0.4498
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0069	0.1404	0.1379
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Brugia malayi	Fibronectin type III domain containing protein	0.011	0.3287	0.5611
Brugia malayi	Protein-tyrosine phosphatase	0.0091	0.2434	0.4141
Entamoeba histolytica	protein kinase, putative	0.0051	0.0592	0.5457
Echinococcus granulosus	tyrosine protein kinase Blk	0.0069	0.1404	0.1379
Echinococcus granulosus	titin	0.0063	0.113	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0091	0.2434	0.2411
Schistosoma mansoni	nephrin related	0.0063	0.113	0.1177
Echinococcus granulosus	plexin a4	0.0041	0.0142	0.0113
Brugia malayi	Immunoglobulin I-set domain containing protein	0.011	0.3287	0.5611
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Brugia malayi	Immunoglobulin I-set domain containing protein	0.016	0.5573	0.9549
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.016	0.5573	0.556
Schistosoma mansoni	ephrin receptor	0.0123	0.3875	0.4094
Echinococcus granulosus	epidermal growth factor receptor	0.0092	0.2469	0.2447
Schistosoma mansoni	titin	0.0063	0.113	0.1177
Brugia malayi	SRC-1	0.0076	0.1716	0.2905
Echinococcus multilocularis	Netrin receptor DCC	0.0091	0.2434	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Loa Loa (eye worm)	hypothetical protein	0.011	0.3287	0.3349
Schistosoma mansoni	cell adhesion molecule	0.0116	0.3565	0.3764
Echinococcus multilocularis	twitchin	0.0065	0.1209	0.1183
Brugia malayi	Prion-like-	0.0063	0.113	0.1895
Schistosoma mansoni	neuroglian	0.016	0.5573	0.5897
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.5295	0.907
Echinococcus granulosus	insulin receptor	0.0166	0.5835	0.5822
Echinococcus granulosus	hemicentin 1	0.0069	0.1408	0.1382
Echinococcus multilocularis	usherin	0.0091	0.2434	0.2411
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0051	0.0592	0.0578
Echinococcus granulosus	tyrosine protein kinase otk	0.0069	0.1408	0.1382
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0098	0.2712	0.269
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0091	0.2434	0.2411
Onchocerca volvulus		0.0091	0.2434	0.4498
Echinococcus granulosus	Netrin receptor DCC	0.0091	0.2434	0.2411
Schistosoma mansoni	hypothetical protein	0.0063	0.113	0.1177
Loa Loa (eye worm)	TK protein kinase	0.0069	0.1404	0.1414
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0154	0.5295	0.5281
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Schistosoma mansoni	tripartite motif protein trim9	0.0091	0.2434	0.2562
Echinococcus granulosus	titin	0.0063	0.113	0.1103
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0063	0.113	0.1177
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.0729	0.0701
Entamoeba histolytica	protein kinase domain containing protein	0.0051	0.0592	0.5457
Schistosoma mansoni	tyrosine kinase	0.0101	0.2849	0.3004
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0063	0.113	0.1103
Brugia malayi	protein unc-22	0.0156	0.5375	0.9207
Brugia malayi	Protein kinase domain containing protein	0.0106	0.3076	0.5248
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0063	0.113	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1408	0.1417
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0091	0.2434	0.2472
Echinococcus granulosus	nephrin	0.0154	0.5295	0.5281
Schistosoma mansoni	tyrosine kinase	0.0039	0.003	0.0008
Brugia malayi	Furin-like cysteine rich region family protein	0.0092	0.2469	0.4202
Loa Loa (eye worm)	projectin	0.0154	0.5295	0.5414
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.0729	0.0701
Onchocerca volvulus		0.0091	0.2434	0.4498
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0729	1
Echinococcus granulosus	insulin growth factor binding	0.0063	0.113	0.1103
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0729	0.0751
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0063	0.113	0.1131
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0063	0.113	0.1103
Onchocerca volvulus		0.0091	0.2434	0.4498
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0054	0.0729	0.0743
Brugia malayi	Fibronectin type III domain containing protein	0.0091	0.2434	0.4141
Brugia malayi	Fibronectin type III domain containing protein	0.0091	0.2434	0.4141
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Schistosoma mansoni	cell adhesion molecule	0.016	0.5573	0.5897
Echinococcus multilocularis	protein kinase shaggy	0.0051	0.0592	0.0564
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0063	0.113	0.1103
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0092	0.2469	0.2508
Onchocerca volvulus		0.0091	0.2434	0.4498
Echinococcus multilocularis	anosmin 1	0.0091	0.2434	0.2411
Schistosoma mansoni	tyrosine kinase	0.0046	0.0341	0.0339
Schistosoma mansoni	slit	0.0063	0.113	0.1177
Brugia malayi	Fibronectin type III domain containing protein	0.0091	0.2434	0.4141
Echinococcus multilocularis	Netrin receptor DCC	0.0091	0.2434	0.2411
Loa Loa (eye worm)	hypothetical protein	0.011	0.3287	0.3349
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Schistosoma mansoni	tyrosine kinase	0.0245	0.9435	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Echinococcus multilocularis	hemicentin 1	0.0069	0.1408	0.1382
Echinococcus granulosus	protein kinase shaggy	0.0051	0.0592	0.0564
Echinococcus multilocularis	hemicentin 1	0.0069	0.1408	0.1382
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0091	0.2434	0.2562
Brugia malayi	Disorganized muscle protein 1	0.0063	0.113	0.1895
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0056	0.0841	0.1398
Schistosoma mansoni	cell adhesion molecule	0.016	0.5573	0.5897
Schistosoma mansoni	tyrosine kinase	0.0039	0.003	0.0008
Plasmodium falciparum	glycogen synthase kinase 3	0.0051	0.0592	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1408	0.1417
Onchocerca volvulus		0.0091	0.2434	0.4498
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0091	0.2434	0.2562
Echinococcus granulosus	EG95	0.0091	0.2434	0.2411
Schistosoma mansoni	titin	0.0063	0.113	0.1177
Loa Loa (eye worm)	TK/INSR protein kinase	0.0166	0.5835	0.5969
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Loa Loa (eye worm)	plexin A	0.0041	0.0142	0.0116
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0076	0.1716	0.1691
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1408	0.1417
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.5295	0.907
Onchocerca volvulus		0.0063	0.113	0.2058
Loa Loa (eye worm)	myotactin form A	0.0091	0.2434	0.2472
Brugia malayi	Immunoglobulin I-set domain containing protein	0.016	0.5573	0.9549
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0091	0.2434	0.2472
Echinococcus multilocularis	neuroglian	0.0082	0.1983	0.1959
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0077	0.1796	0.1771
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0091	0.2434	0.2562
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0091	0.2434	0.2411
Echinococcus granulosus	roundabout 2	0.016	0.5573	0.556
Brugia malayi	protein-tyrosine kinase	0.0069	0.1404	0.2368
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0054	0.0729	0.0743
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.5295	0.907
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Schistosoma mansoni	tyrosine kinase	0.0092	0.2469	0.26
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.016	0.5573	0.556
Loa Loa (eye worm)	one IG domain family member	0.0063	0.113	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Schistosoma mansoni	serine/threonine protein kinase	0.0156	0.5375	0.5686
Schistosoma mansoni	hypothetical protein	0.0063	0.113	0.1177
Schistosoma mansoni	hypothetical protein	0.0063	0.113	0.1177
Schistosoma mansoni	factor for adipocyte differentiation	0.0091	0.2434	0.2562
Schistosoma mansoni	factor for adipocyte differentiation	0.0091	0.2434	0.2562
Loa Loa (eye worm)	animal heme peroxidase	0.0063	0.113	0.1131
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.1408	0.2374
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0063	0.113	0.1131
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.0729	0.0719
Schistosoma mansoni	hypothetical protein	0.0063	0.113	0.1177
Echinococcus multilocularis	titin	0.0063	0.113	0.1103
Echinococcus granulosus	roundabout 2	0.0179	0.6426	0.6415
Schistosoma mansoni	tyrosine kinase	0.0076	0.1716	0.18
Brugia malayi	MAP kinase sur-1	0.0054	0.0729	0.1205
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0063	0.113	0.1131
Loa Loa (eye worm)	TK/ABL protein kinase	0.0252	0.9755	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0076	0.1716	0.1691
Brugia malayi	intracellular kinase	0.0051	0.0592	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Schistosoma mansoni	tyrosine kinase	0.0166	0.5835	0.6175
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0063	0.113	0.1131
Echinococcus granulosus	anosmin 1	0.0091	0.2434	0.2411
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Echinococcus multilocularis	transfer RNA-Phe	0.0154	0.5295	0.5281
Loa Loa (eye worm)	lethal protein 805	0.0091	0.2434	0.2472
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.113	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0063	0.113	0.1131
Brugia malayi	myotactin form A	0.0091	0.2434	0.4141
Onchocerca volvulus		0.0063	0.113	0.2058
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.016	0.5573	0.556
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0046	0.0341	0.0312
Onchocerca volvulus		0.0051	0.0592	0.1052
Echinococcus multilocularis	peroxidasin	0.0069	0.1408	0.1382
Schistosoma mansoni	titin	0.0156	0.5375	0.5686
Echinococcus granulosus	down syndrome cell adhesion	0.0063	0.113	0.1103
Brugia malayi	Immunoglobulin I-set domain containing protein	0.016	0.5573	0.9549
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Echinococcus granulosus	G1Y162 protein	0.0091	0.2434	0.2411
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.1408	0.2374
Schistosoma mansoni	hypothetical protein	0.0154	0.5295	0.5602
Schistosoma mansoni	tyrosine kinase	0.0061	0.1027	0.1068
Schistosoma mansoni	hemicentin	0.0154	0.5295	0.5602
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0091	0.2434	0.2411
Echinococcus multilocularis	c src tyrosine kinase	0.0046	0.0341	0.0312
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0098	0.2712	0.2758
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0076	0.1716	0.1691
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0091	0.2434	0.4141
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.0729	0.0701
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0076	0.1716	0.1691
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0091	0.2434	0.2411
Brugia malayi	Prion-like-	0.0063	0.113	0.1895
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.5295	0.5414
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0063	0.113	0.1103
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0069	0.1408	0.2578
Schistosoma mansoni	tyrosine kinase	0.0076	0.1716	0.18
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0069	0.1404	0.1379
Loa Loa (eye worm)	UNCoordinated family member	0.0091	0.2434	0.2472
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1408	0.1417
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0076	0.1716	0.1691
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.016	0.5573	0.57
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0091	0.2434	0.4141
Brugia malayi	hypothetical protein	0.011	0.3287	0.5611
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.5295	0.907
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2434	0.2472
Echinococcus granulosus	anosmin 1	0.0091	0.2434	0.2411
Entamoeba histolytica	protein kinase domain containing protein	0.0051	0.0592	0.5457
Brugia malayi	Tyrosine-protein kinase abl-1	0.0132	0.4275	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1408	0.1417
Schistosoma mansoni	serine/threonine protein kinase	0.0065	0.1209	0.1262
Schistosoma mansoni	nephrin	0.016	0.5573	0.5897
Echinococcus granulosus	neuroglian	0.016	0.5573	0.556
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0063	0.113	0.1103
Onchocerca volvulus	Putative titin	0.0063	0.113	0.2058

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	> 10 mg kg-1	Tested for the protection against glutamic acid-evoked convulsions in rats by intraperitoneal administration	ChEMBL.	10425092

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 157964