Detailed information for compound 161014

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.553 | Formula: C21H30N4O3S
  • H donors: 0 H acceptors: 1 LogP: 2.69 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1OCCN(CCCN1CCCSc2c1cnn(c2=O)C)C
  • InChi: 1S/C21H30N4O3S/c1-23(13-14-28-19-9-5-4-8-18(19)27-3)10-6-11-25-12-7-15-29-20-17(25)16-22-24(2)21(20)26/h4-5,8-9,16H,6-7,10-15H2,1-3H3
  • InChiKey: WEZRQNRGEWUYOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutathione reductase 0.0068 0.1778 0.2751
Echinococcus multilocularis insulin receptor 0.0073 0.1948 0.3615
Echinococcus granulosus c src tyrosine kinase 0.017 0.5367 1
Echinococcus multilocularis NCK adaptor protein 0.0097 0.2812 0.5229
Schistosoma mansoni tensin 0.0097 0.2812 0.4
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0097 0.2812 0.5229
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0024 0.0219 0.5
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0697 0.1279
Brugia malayi Furin-like cysteine rich region family protein 0.0073 0.1948 0.3028
Echinococcus granulosus tyrosine protein kinase Fyn 0.017 0.5367 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0073 0.1948 0.3615
Echinococcus granulosus tensin 0.0097 0.2812 0.5229
Echinococcus multilocularis tyrosine protein kinase ABL1 0.017 0.5367 1
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) SH2 domain-containing protein 0.0097 0.2812 0.4361
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.1948 0.2765
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.1948 0.3615
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Plasmodium falciparum protein kinase, putative 0.0073 0.1948 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) TK/Met protein kinase 0.0073 0.1948 0.3015
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.1948 0.3615
Loa Loa (eye worm) STAT protein 0.0097 0.2812 0.4361
Schistosoma mansoni tensin 0.0097 0.2812 0.4
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) TK protein kinase 0.0073 0.1948 0.3015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0219 0.0933
Schistosoma mansoni hypothetical protein 0.0097 0.2812 0.4
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1948 0.3015
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Onchocerca volvulus 0.017 0.5367 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 1 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.2812 0.5229
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0024 0.0219 0.0933
Brugia malayi Bromodomain containing protein 0.004 0.0783 0.1217
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0024 0.0219 0.0933
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0219 0.0933
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0097 0.2812 0.5229
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus multilocularis tyrosine protein kinase Fyn 0.017 0.5367 1
Echinococcus granulosus tyrosine protein kinase 0.0073 0.1948 0.3615
Schistosoma mansoni SH2A 0.0097 0.2812 0.4
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Trypanosoma brucei Pseudokinase, putative 0.0073 0.1948 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0073 0.1948 0.3028
Schistosoma mansoni tyrosine kinase 0.017 0.5367 0.7649
Echinococcus multilocularis tyrosine protein kinase Fyn 0.017 0.5367 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0097 0.2812 0.5229
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.017 0.5367 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Brugia malayi Protein kinase domain containing protein 0.017 0.5367 0.8343
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Brugia malayi STAT protein, DNA binding domain containing protein 0.0097 0.2812 0.4371
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1948 0.1767
Echinococcus granulosus raf serine:threonine protein kinase 0.0073 0.1948 0.3615
Loa Loa (eye worm) hypothetical protein 0.0044 0.0941 0.1447
Entamoeba histolytica SH2 domain containing protein 0.0097 0.2812 0.1073
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0024 0.0219 0.0278
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.1948 0.2765
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1948 0.1767
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0073 0.1948 0.3015
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus granulosus SH2 domain containing protein 7 0.0097 0.2812 0.5229
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.156 0.289
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.1948 0.3615
Brugia malayi bone morphogenetic protein type 1 receptor 0.0073 0.1948 0.3028
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0073 0.1948 0.3615
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0024 0.0219 0.0933
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0219 0.0933
Schistosoma mansoni tyrosine kinase 0.017 0.5367 0.7649
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0097 0.2812 0.5229
Brugia malayi Thioredoxin reductase 0.0068 0.1778 0.2764
Brugia malayi hypothetical protein 0.0073 0.1948 0.3028
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0073 0.1948 0.3015
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.017 0.5367 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0073 0.1948 0.3615
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0024 0.0219 0.0341
Echinococcus granulosus tyrosine protein kinase shark 0.017 0.5367 1
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Brugia malayi cytokine inducible SH2-containing protein 5 0.0097 0.2812 0.4371
Echinococcus granulosus zinc finger protein 0.002 0.0103 0.0171
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0024 0.0219 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1948 0.1767
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Echinococcus granulosus growth factor receptor bound protein 2 0.0097 0.2812 0.5229
Schistosoma mansoni tyrosine protein kinase 0.0073 0.1948 0.2765
Brugia malayi hypothetical protein 0.017 0.5367 0.8343
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0097 0.2812 0.4361
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0073 0.1948 0.3615
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Loa Loa (eye worm) glutaminase 2 0.02 0.6433 1
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Mycobacterium tuberculosis Probable reductase 0.0155 0.4833 0.8876
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus granulosus protein kinase 0.0073 0.1948 0.3615
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.1948 0.3028
Echinococcus multilocularis heat shock protein 70 0.0073 0.1948 0.3615
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Echinococcus multilocularis tyrosine protein kinase 0.0073 0.1948 0.3615
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Echinococcus granulosus hypothetical protein 0.0097 0.2812 0.5229
Plasmodium falciparum glutathione reductase 0.0068 0.1778 0.9017
Echinococcus multilocularis c src tyrosine kinase 0.017 0.5367 1
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0073 0.1948 0.1767
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Echinococcus granulosus natriuretic peptide receptor 1 0.0073 0.1948 0.3615
Schistosoma mansoni signal transduction protein lnk-related 0.0097 0.2812 0.4
Brugia malayi RhoGAP domain containing protein 0.0097 0.2812 0.4371
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Toxoplasma gondii protein kinase domain-containing protein 0.0073 0.1948 1
Brugia malayi Bromodomain containing protein 0.0078 0.2115 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1948 0.2765
Brugia malayi Calcitonin receptor-like protein seb-1 0.0037 0.0677 0.1052
Echinococcus multilocularis kinase suppressor of Ras 1 0.0073 0.1948 0.3615
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0024 0.0219 0.0278
Echinococcus granulosus NCK adaptor protein 0.0097 0.2812 0.5229
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0097 0.2812 0.4361
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.017 0.5367 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1948 0.3015
Echinococcus multilocularis N chimaerin 0.0097 0.2812 0.5229
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Brugia malayi Sex muscle abnormal protein 5 0.0097 0.2812 0.4371
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0211 0.0285
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0302 1 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.1948 0.3028
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.1948 0.3028
Loa Loa (eye worm) TK protein kinase 0.0073 0.1948 0.3015
Brugia malayi PHD-finger family protein 0.0026 0.0297 0.0462
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Echinococcus multilocularis protein KINase family member (kin 25) 0.0073 0.1948 0.3615
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0068 0.1792 0.3324
Toxoplasma gondii protein kinase 0.0073 0.1948 1
Treponema pallidum fructose-bisphosphate aldolase 0.0302 1 1
Echinococcus granulosus tyrosine kinase 0.017 0.5367 1
Schistosoma mansoni tensin-related 0.0097 0.2812 0.4
Echinococcus multilocularis 0.0018 0.0042 0.0056
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0097 0.2812 0.4361
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Echinococcus granulosus N chimaerin 0.0097 0.2812 0.5229
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Brugia malayi latrophilin 2 splice variant baaae 0.0025 0.0271 0.0421
Echinococcus granulosus tyrosine protein kinase Fyn 0.017 0.5367 1
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0097 0.2812 0.5229
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.1948 0.3015
Onchocerca volvulus 0.0097 0.2812 0.2528
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) TK protein kinase 0.0073 0.1948 0.3015
Schistosoma mansoni vav2 0.0097 0.2812 0.4
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0219 0.0933
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Loa Loa (eye worm) SH2 domain-containing protein 0.0097 0.2812 0.4361
Echinococcus granulosus tyrosine kinase 0.017 0.5367 1
Plasmodium falciparum tyrosine kinase-like protein 0.0073 0.1948 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0155 0.4833 0.8876
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0097 0.2812 0.4361
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.156 0.289
Loa Loa (eye worm) hypothetical protein 0.0073 0.196 0.3033
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.1948 0.3028
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.1948 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.1948 1
Brugia malayi Tyrosine-protein kinase PR2 0.0073 0.1948 0.3028
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0097 0.2812 0.2528
Loa Loa (eye worm) TK/RYK protein kinase 0.0073 0.1948 0.3015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0219 0.0933
Brugia malayi Cytochrome P450 family protein 0.0058 0.1441 0.2239
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Echinococcus granulosus suppressor of cytokine signaling 7 0.0097 0.2812 0.5229
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0363 0.0547
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Onchocerca volvulus 0.0097 0.2812 0.2528
Trypanosoma cruzi protein kinase, putative 0.0073 0.1948 1
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Plasmodium falciparum protein kinase, putative 0.0073 0.1948 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0697 0.1279
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 1 1
Toxoplasma gondii thioredoxin reductase 0.0068 0.1778 0.9109
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0024 0.0219 0.0933
Echinococcus multilocularis protein kinase 0.0073 0.1948 0.3615
Schistosoma mansoni suppressor of cytokine signaling 0.0097 0.2812 0.4
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0097 0.2812 0.4
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Echinococcus granulosus tyrosine protein kinase Src64B 0.017 0.5367 1
Entamoeba histolytica protein kinase, putative 0.0097 0.2812 0.1073
Echinococcus multilocularis tyrosine kinase 0.0073 0.1948 0.3615
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0219 0.0933
Loa Loa (eye worm) TK protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) TK/DDR protein kinase 0.0073 0.1948 0.3015
Echinococcus granulosus protein tyrosine kinase 0.0073 0.1948 0.3615
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.1948 0.3028
Brugia malayi SH2 domain containing protein 0.017 0.5367 0.8343
Loa Loa (eye worm) glutaminase 0.02 0.6433 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 1 1
Schistosoma mansoni tyrosine kinase 0.017 0.5367 0.7649
Trypanosoma brucei protein kinase, putative 0.0073 0.1948 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Echinococcus multilocularis SH2 motif 0.0097 0.2812 0.5229
Brugia malayi hypothetical protein 0.0097 0.2812 0.4371
Onchocerca volvulus 0.0097 0.2812 0.2528
Loa Loa (eye worm) hypothetical protein 0.0025 0.0271 0.0403
Schistosoma mansoni growth factor receptor-bound protein 0.0097 0.2812 0.4
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.1948 0.3615
Brugia malayi Tyrosine-protein kinase abl-1 0.017 0.5367 0.8343
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Onchocerca volvulus 0.0097 0.2812 0.2528
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0073 0.1948 0.1767
Echinococcus granulosus tyrosine protein kinase Btk29A 0.017 0.5367 1
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.1948 0.3615
Echinococcus multilocularis integrin linked protein kinase 0.0073 0.1948 0.3615
Brugia malayi Tensin 0.0097 0.2812 0.4371
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0219 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.1948 1
Brugia malayi Protein kinase domain containing protein 0.017 0.5367 0.8343
Echinococcus multilocularis serotonin receptor 0.015 0.4658 0.8677
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0073 0.1948 0.3615
Brugia malayi Variant SH3 domain containing protein 0.0097 0.2812 0.4371
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0037 0.0677 0.1036
Onchocerca volvulus 0.0097 0.2812 0.2528
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1948 0.3615
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0172 0.544 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0219 0.0933
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.1948 0.2765
Loa Loa (eye worm) TK/CSK protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0363 0.0547
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0219 0.5
Trichomonas vaginalis STE family protein kinase 0.0073 0.1948 0.1767
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0172 0.544 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0073 0.1948 0.3015
Brugia malayi Cytochrome P450 family protein 0.0028 0.0363 0.0564
Schistosoma mansoni GTPase activating protein 0.0097 0.2812 0.4
Echinococcus granulosus kinase suppressor of Ras 1 0.0073 0.1948 0.3615
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0097 0.2812 0.4
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0024 0.0219 0.0278
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Brugia malayi Protein kinase domain containing protein 0.017 0.5367 0.8343
Brugia malayi glutathione reductase 0.0068 0.1778 0.2764
Brugia malayi C-terminal src kinase protein 1 0.0073 0.1948 0.3028
Echinococcus granulosus tyrosine protein kinase Srms 0.017 0.5367 1
Brugia malayi cytochrome P450 0.0018 0.0042 0.0065
Entamoeba histolytica SH2-protein kinase domain containing protein 0.017 0.5367 0.4246
Echinococcus multilocularis receptor type guanylyl cyclase 0.0073 0.1948 0.3615
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0024 0.0219 0.0388
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Echinococcus multilocularis tyrosine protein kinase Fyn 0.017 0.5367 1
Plasmodium falciparum thioredoxin reductase 0.0068 0.1778 0.9017
Schistosoma mansoni adapter molecule crk 0.0097 0.2812 0.4
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.1948 0.1767
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.017 0.5367 1
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Brugia malayi Protein kinase domain containing protein 0.017 0.5367 0.8343
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.017 0.5367 1
Brugia malayi Receptor family ligand binding region containing protein 0.0073 0.1948 0.3028
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) hypothetical protein 0.017 0.5367 0.834
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1948 0.3015
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0037 0.0677 0.1052
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0155 0.4833 0.8876
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0024 0.0219 0.0933
Schistosoma mansoni cytochrome P450 0.0018 0.0042 0.0043
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0155 0.4833 0.8876
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0097 0.2812 0.4361
Echinococcus multilocularis signal transduction protein lnk realted 0.0097 0.2812 0.5229
Loa Loa (eye worm) hypothetical protein 0.015 0.4658 0.7236
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.1948 0.3615
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Echinococcus multilocularis tyrosine protein kinase Srms 0.017 0.5367 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0219 0.0933
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0363 0.0503
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.1948 0.3028
Loa Loa (eye worm) TK protein kinase 0.0073 0.1948 0.3015
Echinococcus multilocularis FL cytokine receptor 0.0073 0.1948 0.3615
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0097 0.2812 0.5229
Echinococcus multilocularis SHC transforming protein 3 0.0097 0.2812 0.5229
Echinococcus multilocularis SH2 motif 0.0097 0.2812 0.5229
Echinococcus granulosus tyrosine protein kinase ABL1 0.017 0.5367 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0219 0.0933
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.1948 1
Echinococcus multilocularis tensin 0.0097 0.2812 0.5229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.1948 0.3615
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 1 1
Echinococcus granulosus activin receptor type 0.0073 0.1948 0.3615
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Echinococcus multilocularis GA binding protein alpha chain 0.0058 0.1422 0.2634
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1948 0.1767
Loa Loa (eye worm) TK protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.1778 0.9109
Giardia lamblia Kinase, NEK 0.0073 0.1948 0.1767
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1948 0.3615
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.4574 0.7092
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1948 0.1767
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Brugia malayi Ets-domain containing protein 0.0058 0.1422 0.2211
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni shc transforming protein 0.0097 0.2812 0.4
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 1 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.4574 0.8396
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Giardia lamblia Kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) hypothetical protein 0.015 0.4658 0.7236
Echinococcus granulosus tyrosine protein kinase Fyn 0.017 0.5367 1
Schistosoma mansoni hypothetical protein 0.0124 0.3757 0.5349
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0073 0.1948 0.2765
Schistosoma mansoni hypothetical protein 0.0124 0.3757 0.5349
Loa Loa (eye worm) fli-1 protein 0.0175 0.5554 0.8631
Schistosoma mansoni zinc finger protein 0.002 0.0103 0.0131
Brugia malayi Cytochrome P450 family protein 0.0018 0.0042 0.0065
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Loa Loa (eye worm) SH2 domain-containing protein 0.0097 0.2812 0.4361
Echinococcus multilocularis activated cdc42 kinase 1 0.0073 0.1948 0.3615
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni hypothetical protein 0.0021 0.0142 0.0186
Brugia malayi glutaminase DH11.1 0.02 0.6433 1
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.1948 0.3615
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0097 0.2812 0.1073
Echinococcus multilocularis zinc finger protein 0.002 0.0103 0.0171
Onchocerca volvulus 0.017 0.5367 1
Echinococcus granulosus insulin receptor 0.0073 0.1948 0.3615
Echinococcus granulosus SH2 domain containing adapter protein F 0.0097 0.2812 0.5229
Echinococcus multilocularis tyrosine protein kinase Fgr 0.017 0.5367 1
Schistosoma mansoni hypothetical protein 0.0073 0.1948 0.2765
Brugia malayi Protein kinase domain containing protein 0.017 0.5367 0.8343
Leishmania major hypothetical protein, conserved 0.0073 0.1948 1
Schistosoma mansoni ephrin receptor 0.0073 0.1948 0.2765
Brugia malayi hypothetical protein 0.0073 0.1948 0.3028
Schistosoma mansoni bromodomain containing protein 0.0065 0.1689 0.2396
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni biogenic amine (5HT) receptor 0.015 0.4658 0.6637
Schistosoma mansoni tyrosine kinase 0.017 0.5367 0.7649
Giardia lamblia Kinase, NEK 0.0073 0.1948 0.1767
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0042 0.0056
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.1948 0.3615
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.1948 0.3015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 1 1
Schistosoma mansoni hypothetical protein 0.0018 0.0042 0.0043
Echinococcus multilocularis tyrosine protein kinase shark 0.017 0.5367 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus granulosus geminin 0.0124 0.3757 0.6993
Plasmodium falciparum tyrosine kinase-like protein 0.0073 0.1948 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus multilocularis transfer RNA-Thr 0.0073 0.1948 0.3615
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Brugia malayi SH2 domain containing protein 0.0097 0.2812 0.4371
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0073 0.1948 0.3615
Giardia lamblia Fructose-bisphosphate aldolase 0.0302 1 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0097 0.2812 0.5229
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0024 0.0219 0.0329
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Leishmania major protein kinase, putative 0.0073 0.1948 1
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1948 0.2765
Onchocerca volvulus 0.017 0.5367 1
Loa Loa (eye worm) cytochrome P450 0.0018 0.0042 0.0046
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0155 0.4833 0.8876
Loa Loa (eye worm) TK/ALK protein kinase 0.0073 0.1948 0.3015
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.1948 0.3615
Loa Loa (eye worm) hypothetical protein 0.0144 0.4452 0.6915
Brugia malayi SRC-1 0.017 0.5367 0.8343
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0219 0.0933
Loa Loa (eye worm) TK protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0097 0.2812 0.4361
Trichomonas vaginalis TK family protein kinase 0.0073 0.1948 0.1767
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1948 0.2765
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus granulosus tyrosine protein kinase Blk 0.017 0.5367 1
Echinococcus multilocularis serotonin receptor 0.015 0.4658 0.8677
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.1948 0.3615
Loa Loa (eye worm) TK protein kinase 0.0073 0.1948 0.3015
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0073 0.1948 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0142 0.0202
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Echinococcus granulosus fibroblast growth factor receptor 4 0.0073 0.1948 0.3615
Loa Loa (eye worm) TK/FAK protein kinase 0.0073 0.1948 0.3015
Schistosoma mansoni suppressor of cytokine signaling 0.0097 0.2812 0.4
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1948 0.3015
Echinococcus multilocularis tyrosine protein kinase HCK 0.0073 0.1948 0.3615
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1948 0.3015
Echinococcus multilocularis 0.0097 0.2812 0.5229
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0058 0.1422 0.2196
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.1948 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.1948 0.3615
Mycobacterium tuberculosis Probable dehydrogenase 0.0155 0.4833 0.8876
Echinococcus granulosus expressed conserved protein 0.0097 0.2812 0.5229
Brugia malayi Variant SH3 domain containing protein 0.0097 0.2812 0.4371
Leishmania major trypanothione reductase 0.0068 0.1778 0.9109
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0073 0.1948 0.1767
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0097 0.2812 0.5229
Echinococcus multilocularis growth factor receptor bound protein 2 0.0097 0.2812 0.5229
Onchocerca volvulus 0.0097 0.2812 0.2528
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Brugia malayi Guanylyl cyclase protein 23 0.0073 0.1948 0.3028
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0034 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0097 0.2812 0.4371
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni ephrin receptor 0.0073 0.1948 0.2765
Mycobacterium tuberculosis Probable oxidoreductase 0.0172 0.544 1
Brugia malayi Fli-1 protein 0.0175 0.5554 0.8633
Echinococcus granulosus signal transduction protein lnk realted 0.0097 0.2812 0.5229
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) TK/ACK protein kinase 0.0073 0.1948 0.3015
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni glutaminase 0.02 0.6433 0.9171
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.1948 0.3615
Echinococcus multilocularis tyrosine protein kinase Src64B 0.017 0.5367 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.017 0.5367 1
Brugia malayi SH2 domain containing protein 0.0097 0.2812 0.4371
Echinococcus granulosus SH2 motif 0.0097 0.2812 0.5229
Plasmodium vivax thioredoxin reductase, putative 0.0068 0.1778 0.9017
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0363 0.0547
Loa Loa (eye worm) TK protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Echinococcus granulosus GA binding protein alpha chain 0.0058 0.1422 0.2634
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Echinococcus granulosus SH2 motif 0.0097 0.2812 0.5229
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0073 0.1948 0.3028
Toxoplasma gondii NADPH-glutathione reductase 0.0024 0.0219 0.0933
Echinococcus granulosus suppressor of cytokine signaling 6 0.0097 0.2812 0.5229
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Echinococcus granulosus biogenic amine 5HT receptor 0.015 0.4658 0.8677
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.2812 0.5229
Brugia malayi SH2 domain containing protein 0.017 0.5367 0.8343
Leishmania major protein kinase, putative 0.0073 0.1948 1
Schistosoma mansoni growth factor receptor-bound protein 0.0097 0.2812 0.4
Trichomonas vaginalis protein tyrosine kinase, putative 0.0073 0.1948 0.1767
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.1948 0.3615
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0073 0.1948 0.1767
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0097 0.2812 0.4
Loa Loa (eye worm) SRC-1 0.017 0.5367 0.834
Mycobacterium ulcerans glutaminase 0.02 0.6433 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.1948 0.3615
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0073 0.1948 0.3015
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.1948 0.3615
Plasmodium vivax glutathione reductase, putative 0.0068 0.1778 0.9017
Brugia malayi N-terminal motif family protein 0.0144 0.4452 0.692
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0097 0.2812 0.4
Echinococcus granulosus SHC transforming protein 3 0.0097 0.2812 0.5229
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.1948 0.3615
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1948 0.1767
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni nck2/grb4 0.0097 0.2812 0.4
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni ets-related 0.0175 0.5554 0.7915
Echinococcus granulosus tyrosine protein kinase Fps85D 0.017 0.5367 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0073 0.1948 0.3615
Loa Loa (eye worm) TK protein kinase 0.017 0.5367 0.834
Trypanosoma brucei trypanothione reductase 0.0068 0.1778 0.9109
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.1948 0.3615
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0363 0.1685
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0097 0.2812 0.5229
Echinococcus granulosus integrin linked protein kinase 0.0073 0.1948 0.3615
Echinococcus granulosus tyrosine protein kinase HCK 0.0073 0.1948 0.3615
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.1948 0.2765
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) TK/EGFR protein kinase 0.0073 0.1948 0.3015
Brugia malayi integrin-linked kinase 0.0073 0.1948 0.3028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0219 0.0933
Brugia malayi SH2 domain containing protein 0.0097 0.2812 0.4371
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.1948 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Brugia malayi tRNA modification GTPase TrmE family protein 0.0097 0.2812 0.4371
Echinococcus granulosus tyrosine protein kinase Src42A 0.017 0.5367 1
Brugia malayi Variant SH3 domain containing protein 0.0097 0.2812 0.4371
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0073 0.1948 0.3615
Loa Loa (eye worm) TK/ABL protein kinase 0.017 0.5367 0.834
Brugia malayi protein-tyrosine kinase 0.017 0.5367 0.8343
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.1948 0.3615
Echinococcus granulosus tyrosine protein kinase pr2 0.0073 0.1948 0.3615
Schistosoma mansoni protein tyrosine kinase 0.0073 0.1948 0.2765
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.017 0.5367 1
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1948 0.2765
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0097 0.2812 0.5229
Echinococcus multilocularis tensin 0.0097 0.2812 0.5229
Schistosoma mansoni hypothetical protein 0.0097 0.2812 0.4
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.1948 0.3615
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0097 0.2812 0.4
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0211 0.0372
Schistosoma mansoni gabp alpha 0.0058 0.1422 0.2014
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) serine/threonine protein kinase 0.0073 0.1948 0.3015
Echinococcus granulosus thioredoxin glutathione reductase 0.0068 0.1792 0.3324
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0073 0.1948 0.3615
Schistosoma mansoni serine/threonine RGC 0.0073 0.1948 0.2765
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis glutaminase, putative 0.02 0.6433 0.6353
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Echinococcus multilocularis activin receptor type 0.0073 0.1948 0.3615
Onchocerca volvulus 0.017 0.5367 1
Schistosoma mansoni hypothetical protein 0.0025 0.0271 0.037
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.1948 0.3615
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Echinococcus multilocularis tyrosine kinase 0.017 0.5367 1
Brugia malayi ephrin receptor 1 precursor 0.0073 0.1948 0.3028
Brugia malayi Cytochrome P450 family protein 0.0028 0.0363 0.0564
Brugia malayi Variant SH3 domain containing protein 0.0097 0.2812 0.4371
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Brugia malayi Ets-domain containing protein 0.0058 0.1422 0.2211
Loa Loa (eye worm) TK/INSR protein kinase 0.0073 0.1948 0.3015
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0073 0.1948 0.3615
Echinococcus multilocularis tyrosine protein kinase Blk 0.017 0.5367 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0097 0.2812 0.5229
Echinococcus multilocularis tyrosine protein kinase Src42A 0.017 0.5367 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0219 0.0933
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0068 0.1778 0.3216
Brugia malayi SH2 domain containing protein 0.0097 0.2812 0.4371
Plasmodium falciparum protein kinase, putative 0.0073 0.1948 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0073 0.1948 0.3015
Echinococcus multilocularis raf serine:threonine protein kinase 0.0073 0.1948 0.3615
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0073 0.1948 0.3615
Plasmodium vivax protein kinase, putative 0.0073 0.1948 1
Giardia lamblia Protein 21.1 0.0073 0.1948 0.1767
Loa Loa (eye worm) hypothetical protein 0.0042 0.0871 0.1339
Brugia malayi SH2 domain containing protein 0.0097 0.2812 0.4371
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0073 0.1948 0.3615
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0172 0.544 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0363 0.1685
Loa Loa (eye worm) TK/EPH protein kinase 0.0073 0.1948 0.3015
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.1948 0.2765
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0073 0.1948 0.3615
Echinococcus multilocularis natriuretic peptide receptor 1 0.0073 0.1948 0.3615
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Schistosoma mansoni tensin-related 0.0097 0.2812 0.4
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Trypanosoma cruzi protein kinase, putative 0.0073 0.1948 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0073 0.1948 0.3015
Echinococcus multilocularis protein kinase 0.0073 0.1948 0.3615
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Loa Loa (eye worm) protein kinase domain-containing protein 0.0073 0.1948 0.3015
Onchocerca volvulus 0.017 0.5367 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0785 0.1205
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.1948 0.3615
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0155 0.4833 0.8876
Loa Loa (eye worm) thioredoxin reductase 0.0068 0.1778 0.2751
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0024 0.0219 0.0296
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0073 0.1948 0.3615
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1948 0.3015
Loa Loa (eye worm) hypothetical protein 0.0049 0.1128 0.1738
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0363 0.1685
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0073 0.1948 0.3615
Brugia malayi Raf kinase 0.0073 0.1948 0.3028
Echinococcus multilocularis tyrosine protein kinase pr2 0.0073 0.1948 0.3615
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0211 0.0372
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.1948 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.017 0.5367 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0097 0.2812 0.5229
Loa Loa (eye worm) hypothetical protein 0.0037 0.0677 0.1036
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0073 0.1948 0.3615
Schistosoma mansoni protein kinase 0.0073 0.1948 0.2765
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0144 0.4452 0.7323
Schistosoma mansoni tyrosine kinase 0.017 0.5367 0.7649
Schistosoma mansoni tensin 0.0097 0.2812 0.4
Echinococcus multilocularis ephrin type A receptor 4 A 0.0073 0.1948 0.3615
Trypanosoma brucei Flagellum attachment zone protein 20 0.0073 0.1948 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0097 0.2812 0.5229
Loa Loa (eye worm) TK/ROR protein kinase 0.0073 0.1948 0.3015
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1948 0.3615
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.017 0.5367 0.7649
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1948 0.3015
Echinococcus granulosus receptor type guanylyl cyclase 0.0073 0.1948 0.3615
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0097 0.2812 0.2528
Echinococcus multilocularis tyrosine protein kinase Abl 0.017 0.5367 1
Echinococcus multilocularis geminin 0.0124 0.3757 0.6993
Schistosoma mansoni tyrosine kinase 0.017 0.5367 0.7649
Echinococcus granulosus tyrosine kinase 0.0073 0.1948 0.3615
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Echinococcus granulosus ephrin type A receptor 4 A 0.0073 0.1948 0.3615
Brugia malayi SH2 domain containing protein 0.0097 0.2812 0.4371
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0073 0.1948 0.3615
Onchocerca volvulus 0.017 0.5367 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1948 0.3615
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.4574 0.8396
Loa Loa (eye worm) TK/FER protein kinase 0.017 0.5367 0.834
Schistosoma mansoni tyrosine kinase 0.0073 0.1948 0.2765
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0219 0.0933
Brugia malayi SH2 domain containing protein 0.0097 0.2812 0.4371
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis protein kinase atn1, putative 0.0073 0.1948 0.1767
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Echinococcus multilocularis SH2 motif 0.0097 0.2812 0.5229
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1948 0.1767
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Trichomonas vaginalis AGC family protein kinase 0.0073 0.1948 0.1767
Leishmania major cytochrome p450-like protein 0.0028 0.0363 0.1685
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.017 0.5367 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.1441 0.2225
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0073 0.1948 1
Echinococcus multilocularis protein tyrosine kinase 0.0073 0.1948 0.3615
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0097 0.2812 0.5229
Loa Loa (eye worm) hypothetical protein 0.0073 0.1948 0.3015
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1948 0.1767
Toxoplasma gondii STE kinase 0.0073 0.1948 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Brugia malayi Protein kinase domain containing protein 0.0073 0.1948 0.3028
Echinococcus granulosus tyrosine protein kinase Lyn 0.017 0.5367 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.2812 0.4361

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 1000 nM Binding affinity towards 5-hydroxytryptamine 1A receptor using receptor binding assay ChEMBL. No reference
IC50 (binding) > 1000 nM Binding affinity towards 5-hydroxytryptamine 1A receptor using receptor binding assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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