Detailed information for compound 1624291

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.333 | Formula: C16H11BrN6S2
  • H donors: 1 H acceptors: 3 LogP: 4.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(s1)/C=N/n1c(S)nnc1c1n[nH]c(c1)c1ccccc1
  • InChi: 1S/C16H11BrN6S2/c17-14-7-6-11(25-14)9-18-23-15(21-22-16(23)24)13-8-12(19-20-13)10-4-2-1-3-5-10/h1-9H,(H,19,20)(H,22,24)/b18-9+
  • InChiKey: HHBWEIPXSCZNHO-GIJQJNRQSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin-like modifier activating enzyme 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Starlite/ChEMBL No references
Homo sapiens SUMO1 activating enzyme subunit 1 No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens small ubiquitin-like modifier 1 Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis 26S proteasome regulatory subunit N11 Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
Entamoeba histolytica ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin like protein Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 Get druggable targets OG5_127757 All targets in OG5_127757
Babesia bovis ubiquitin-like protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome Get druggable targets OG5_127757 All targets in OG5_127757
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus 26S proteasome regulatory subunit N11 Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase Get druggable targets OG5_127757 All targets in OG5_127757
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma japonicum ko:K10684 ubiquitin-like 1-activating enzyme E1 A, putative Get druggable targets OG5_128859 All targets in OG5_128859
Leishmania mexicana ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) proteasome 26S subunit Get druggable targets OG5_127757 All targets in OG5_127757
Leishmania major ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Neospora caninum AFR138Wp, related Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium vivax ubiquitin activating enzyme, putative Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma brucei ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei gambiense small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin-activating enzyme E1 1 Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania major small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Cryptosporidium parvum SUMO-1 activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Small ubiquitin-related modifier 2 precursor, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 Get druggable targets OG5_127757 All targets in OG5_127757
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Cryptosporidium hominis Mov34/MPN/PAD-1 family proteasome regulatory subunit Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei gambiense proteasome regulatory non-ATPase subunit 11,19S proteasome regulatory subunit, Metallo-peptidase, Clan MP, Family M67 Get druggable targets OG5_127757 All targets in OG5_127757
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Theileria parva ubiquitin, putative Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus multilocularis SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma japonicum ko:K10685 ubiquitin-like 1-activating enzyme E1 B, putative Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium berghei SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Echinococcus granulosus Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Theileria parva ubiquitin-protein ligase, putative Get druggable targets OG5_127838 All targets in OG5_127838
Babesia bovis 26S proteasome regulatory subunit, putative Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Leishmania infantum small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Cryptosporidium parvum 26S proteasome-associated Mov34/MPN/PAD-1 family. JAB domain. Get druggable targets OG5_127757 All targets in OG5_127757
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis conserved hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii Mov34/MPN/PAD-1 family, putative Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium knowlesi 26S proteasome regulatory subunit RPN11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 Get druggable targets OG5_127757 All targets in OG5_127757
Plasmodium knowlesi small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium berghei 26S proteasome regulatory subunit RPN11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis SUMO-1 activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Cryptosporidium hominis ubiquitin-like protein Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus granulosus 26S proteasome regulatory subunit N11 Get druggable targets OG5_127757 All targets in OG5_127757
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae RPN11 (YFR004W) deubiquitinylating metalloisopeptidase subunit of the 19S regulatory particle of the 26 Get druggable targets OG5_127757 All targets in OG5_127757
Plasmodium yoelii related to ubiquitin-activating enzyme homolog UBA2-related Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania donovani proteasome regulatory non-ATPase subunit 11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis 26S proteasome regulatory subunit N11 Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus granulosus SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei gambiense ubiquitin-activating enzyme e1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania infantum ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania mexicana proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense proteasome regulatory non-ATPase subunit 11,19S proteasome regulatory subunit, Metallo-peptidase, Clan MP, Family M67, putative Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Neospora caninum hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi 26S proteasome regulatory subunit rpn11 Get druggable targets OG5_127757 All targets in OG5_127757
Schistosoma mansoni ubiquitin-activating enzyme E1b Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii SUMO-1 activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium berghei SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Neospora caninum hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma cruzi ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium berghei small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma japonicum ko:K03030 26S proteasome regulatory subunit N11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Echinococcus multilocularis Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium knowlesi SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma brucei small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva proteasome regulatory subunit, putative Get druggable targets OG5_127757 All targets in OG5_127757
Plasmodium falciparum SUMO-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Toxoplasma gondii small ubiquitin family modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) SMO-1 protein Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III Get druggable targets OG5_127757 All targets in OG5_127757
Plasmodium falciparum SUMO-activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium falciparum small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Toxoplasma gondii proteasome regulatory subunit Get druggable targets OG5_127757 All targets in OG5_127757
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi ThiF family protein Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus sumo-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis SUMO activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Sentrin Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi Ubiquitin-like protein SMT3 Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma congolense ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative Get druggable targets OG5_127838 All targets in OG5_127838
Toxoplasma gondii ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum CBR-CSN-5 protein, related Get druggable targets OG5_127757 All targets in OG5_127757
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 6-cysteine protein small ubiquitin-like modifier 1 101 aa 92 aa 28.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei COP9 signalosome complex subunit 5, putative proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 310 aa 258 aa 27.5 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0028 0.0002 0.0009
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0017 0.0017
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.001 0.0201
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0016 0.0099
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0009 0.0225
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.001 0.001
Plasmodium falciparum plasmepsin I 0.081 0.039 1
Schistosoma mansoni prolyl 4-hydroxylase alpha subunit 1 0.0591 0.0281 0.0281
Leishmania major cytochrome p450-like protein 0.004 0.0008 0.0183
Plasmodium vivax small ubiquitin-related modifier, putative 0.0037 0.0007 0.0147
Echinococcus granulosus hyperpolarization activated cyclic 0.0028 0.0002 0.0035
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0028 0.0002 0.0035
Trypanosoma brucei cytochrome P450, putative 0.004 0.0008 0.0172
Brugia malayi mbt repeat family protein 0.0058 0.0017 0.0409
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0591 0.0281 1
Toxoplasma gondii aspartyl protease 0.081 0.039 0.0947
Loa Loa (eye worm) aspartyl protease 6 0.081 0.039 0.2608
Plasmodium falciparum small ubiquitin-related modifier 0.0037 0.0007 0.0147
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0169 0.5973
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0084 1
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0003 0.0043
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0008 0.0183
Giardia lamblia Sentrin 0.0037 0.0007 0.4733
Toxoplasma gondii hypoxia- inducible factor prolyl hydroxylase (phd2), putative 0.0591 0.0281 0.0682
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.001 0.0244
Leishmania major hypothetical protein, conserved 0.0257 0.0116 0.4051
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.081 0.039 1
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.003 0.0003 0.0003
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0074 0.2549
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.003 0.0003 0.0049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.081 0.039 0.039
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0116 0.4045
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0038 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0007 0.0112
Brugia malayi Ubiquitin-like protein SMT3 0.0037 0.0007 0.0147
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0591 0.0281 1
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0008 0.0048
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0009 0.0213
Loa Loa (eye worm) hypothetical protein 0.081 0.039 0.2608
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0028 0.0002 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.081 0.039 0.039
Toxoplasma gondii hypothetical protein 0.0059 0.0017 0.004
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0119 0.0047 0.1189
Schistosoma mansoni hypothetical protein 0.035 0.0162 0.0162
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.001 0.0269
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0058 0.0017 0.0417
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0021 0.0021
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0007 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.001 0.0209
Plasmodium vivax aspartyl proteinase, putative 0.081 0.039 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0016 0.0016
Plasmodium falciparum plasmepsin VII 0.081 0.039 1
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0116 0.4051
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0014 0.0387
Entamoeba histolytica ubiquitin like protein 0.0037 0.0007 0.6022
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0014 0.0376
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0058 0.0017 0.0417
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0074 0.2549
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.003 0.0003 0.0011
Plasmodium vivax ubiquitin activating enzyme, putative 0.0058 0.0017 0.0417
Onchocerca volvulus 0.081 0.039 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.0474 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.001 0.0209
Brugia malayi hypothetical protein 0.081 0.039 1
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0053 0.0014 0.0014
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0038 0.0007 0.0163
Plasmodium falciparum plasmepsin IV 0.081 0.039 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0101 0.2112
Loa Loa (eye worm) voltage-dependent calcium channel 0.0057 0.0016 0.0104
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0243 0.0109 0.2768
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0018 0.0442
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0243 0.0109 0.2768
Loa Loa (eye worm) prolyl 4-hydroxylase 2 0.0591 0.0281 0.1878
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0243 0.0109 0.2768
Trypanosoma brucei 2OG-Fe(II) oxygenase superfamily, putative 0.0591 0.0281 1
Schistosoma mansoni cathepsin D (A01 family) 0.081 0.039 0.039
Schistosoma mansoni transcription factor btf3 0.0042 0.0009 0.0009
Brugia malayi aspartic protease BmAsp-1, identical 0.081 0.039 1
Brugia malayi beta-NAC-like protein 0.0042 0.0009 0.0213
Toxoplasma gondii transporter, cation channel family protein 0.0057 0.0016 0.0038
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.081 0.039 0.039
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0008 0.0048
Brugia malayi ThiF family protein 0.0038 0.0007 0.0163
Echinococcus granulosus voltage dependent calcium channel 0.0057 0.0016 0.0397
Plasmodium vivax aspartyl protease, putative 0.081 0.039 1
Loa Loa (eye worm) CYP4Cod1 0.004 0.0008 0.0048
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.001 0.0269
Loa Loa (eye worm) hypothetical protein 0.3035 0.1494 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0017 0.0017
Plasmodium vivax plasmepsin IV, putative 0.081 0.039 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0058 0.0017 0.0107
Brugia malayi Cytochrome P450 family protein 0.004 0.0008 0.0183
Brugia malayi ube2i2 protein 0.003 0.0003 0.006
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0009 0.0225
Plasmodium vivax plasmepsin V, putative 0.081 0.039 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.003 0.0003 0.0011
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.001 0.0258
Leishmania major hypothetical protein, unknown function 0.0591 0.0281 1
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0007 0.0007
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0008 0.0632
Loa Loa (eye worm) hypothetical protein 0.0104 0.004 0.0261
Plasmodium falciparum plasmepsin V 0.081 0.039 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0243 0.0109 0.2277
Plasmodium falciparum SUMO-conjugating enzyme UBC9 0.003 0.0003 0.006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0007 0.0138
Echinococcus multilocularis transcription factor btf3 0.0042 0.0009 0.0175
Onchocerca volvulus 0.0591 0.0281 0.7084
Echinococcus multilocularis voltage gated potassium channel 0.0039 0.0007 0.0138
Echinococcus multilocularis sodium channel protein 0.0107 0.0041 0.0857
Loa Loa (eye worm) hypothetical protein 0.0591 0.0281 0.1878
Loa Loa (eye worm) SMO-1 protein 0.0037 0.0007 0.0038
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0017 0.0409
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0021 0.042
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.003 0.0003 0.2447
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0016 0.0016
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0021 0.051
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0007 0.0007
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative 0.003 0.0003 0.006
Toxoplasma gondii tetratricopeptide repeat-containing protein 0.0591 0.0281 0.0682
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0017 0.0336
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0016 0.0312
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0017 0.0409
Loa Loa (eye worm) hypothetical protein 0.0066 0.0021 0.0133
Brugia malayi Cytochrome P450 family protein 0.004 0.0008 0.0183
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.003 0.0003 0.0011
Brugia malayi Cyclic-nucleotide gated cation channel 0.0028 0.0002 0.0035
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0017 0.0017
Echinococcus multilocularis prolyl 4 hydroxylase subunit alpha 1 0.0591 0.0281 0.5926
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.8311 0.4113 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.081 0.039 0.039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0016 0.0379
Loa Loa (eye worm) calcium channel 0.0243 0.0109 0.0722
Toxoplasma gondii hypothetical protein 0.0043 0.001 0.0021
Plasmodium falciparum plasmepsin X 0.081 0.039 1
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0009 0.0055
Mycobacterium ulcerans hypothetical protein 0.0192 0.0084 1
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.081 0.039 0.0947
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.081 0.039 0.8227
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0243 0.0109 0.0722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0016 0.0016
Echinococcus granulosus Small ubiquitin modifier 2 0.0037 0.0007 0.0147
Loa Loa (eye worm) hypothetical protein 0.006 0.0018 0.0115
Echinococcus granulosus hyperpolarization activated cyclic 0.0028 0.0002 0.0035
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0003 0.0052
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.001 0.0209
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0038 0.0007 0.0163
Leishmania major small ubiquitin protein, putative 0.0037 0.0007 0.0133
Brugia malayi aspartic protease BmAsp-2, identical 0.081 0.039 1
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0009 0.0214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0016 0.0379
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.001 0.0201
Echinococcus multilocularis Small ubiquitin modifier 2 0.0037 0.0007 0.0121
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0028 0.0002 0.0029
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0003 0.0017
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0058 0.0017 0.0343
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0101 0.2568
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0038 0.0007 0.0134
Toxoplasma gondii aspartyl protease ASP1 0.081 0.039 0.0947
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.003 0.0003 0.2447
Loa Loa (eye worm) hypothetical protein 0.081 0.039 0.2608
Loa Loa (eye worm) hypothetical protein 0.0045 0.001 0.0064
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0002 0.0002
Plasmodium vivax aspartyl proteinase, putative 0.081 0.039 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.003 0.0003 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0009 0.0199
Plasmodium falciparum plasmepsin IX 0.081 0.039 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0016 0.0312
Echinococcus granulosus transcription factor btf3 0.0042 0.0009 0.0213
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.001 0.0244
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.001 0.0201
Loa Loa (eye worm) hypothetical protein 0.081 0.039 0.2608
Loa Loa (eye worm) hypothetical protein 0.0043 0.001 0.0059
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0019 0.0587
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.003 0.0003 0.0025
Echinococcus granulosus prolyl 4 hydroxylase subunit alpha 1 0.0591 0.0281 0.7203
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0243 0.0109 0.2277
Plasmodium vivax aspartyl protease, putative 0.081 0.039 1
Leishmania major basic transcription factor 3a, putative 0.0042 0.0009 0.0225
Plasmodium falciparum plasmepsin VI 0.081 0.039 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0119 0.0047 0.1189
Brugia malayi Cytochrome P450 family protein 0.0061 0.0019 0.0453
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0243 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0042 0.0009 0.8727
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0028 0.0002 0.0035
Schistosoma mansoni voltage-gated cation channel 0.0243 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0043 0.001 0.0059
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0009 0.8727
Plasmodium falciparum plasmepsin III 0.081 0.039 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0028 0.0002 0.0035
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0243 0.0109 0.2768
Echinococcus multilocularis hyperpolarization activated cyclic 0.0028 0.0002 0.0029
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.001 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.081 0.039 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0028 0.0002 0.0029
Onchocerca volvulus 0.081 0.039 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.0169 0.5968
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0039 0.0007 0.0167
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.081 0.039 0.039
Loa Loa (eye worm) aspartic protease BmAsp-1 0.081 0.039 0.2608
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0009 0.0178
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0052 0.0052
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.001 1
Plasmodium vivax aspartyl protease, putative 0.081 0.039 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0021 0.051
Brugia malayi mbt repeat family protein 0.0058 0.0017 0.0409
Loa Loa (eye worm) hypothetical protein 0.0058 0.0017 0.0109
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.001 0.0244
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0009 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0009 0.0178
Loa Loa (eye worm) hypothetical protein 0.0057 0.0016 0.0104
Loa Loa (eye worm) ube2i2 protein 0.003 0.0003 0.0016
Schistosoma mansoni hypothetical protein 0.0041 0.0009 0.0009
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0028 0.0002 0.0029
Toxoplasma gondii hypothetical protein 0.0058 0.0017 0.0039
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0009 0.002
Trypanosoma brucei small ubiquitin-related modifier 0.0037 0.0007 0.0122
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0074 0.2541
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0038 0.0007 0.0163
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0038 0.0007 0.0155
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.0052
Echinococcus multilocularis voltage dependent calcium channel 0.0243 0.0109 0.2277
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0243 0.0109 0.0109
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.081 0.039 0.039
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.081 0.039 0.039
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0002 0.0002
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0037 0.0007 0.0007
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.081 0.039 0.0947
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0243 0.0109 0.2277
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0028 0.0002 0.0029
Echinococcus multilocularis voltage dependent calcium channel 0.0243 0.0109 0.2277
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.081 0.039 0.039
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0028 0.0002 0.0002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.081 0.039 0.039
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0119 0.0047 0.031
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0116 0.4051
Plasmodium falciparum plasmepsin VIII, putative 0.081 0.039 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0009 0.0178
Brugia malayi ThiF family protein 0.0058 0.0017 0.0417
Brugia malayi Pepsin A precursor 0.081 0.039 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0018 0.0115
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0008 0.0183
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0058 0.0017 0.0017
Leishmania major ubiquitin-activating enzyme-like protein 0.0038 0.0007 0.0155
Toxoplasma gondii ThiF family protein 0.0038 0.0007 0.0015
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0038 0.0007 0.0144
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0017 0.0107
Echinococcus granulosus voltage gated potassium channel 0.0039 0.0007 0.0167
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0107 0.0041 0.1041
Brugia malayi prolyl 4-hydroxylase 0.0591 0.0281 0.7203
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0021 0.051
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0005 0.006
Toxoplasma gondii small ubiquitin family modifier, putative 0.0037 0.0007 0.0014
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0014 0.0387
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0028 0.0002 0.0002
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.001 0.001
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0151 0.0063 0.2156
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0243 0.0109 0.2277
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0028 0.0002 0.0035
Toxoplasma gondii aspartyl protease ASP3 0.081 0.039 0.0947
Loa Loa (eye worm) MBCTL1 0.0066 0.0021 0.0133
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0007 0.0133
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.0169 0.5973
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0041 0.0987
Echinococcus granulosus voltage dependent calcium channel 0.0243 0.0109 0.2768
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0014 0.0387
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.001 0.0269
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0018 0.0442
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.081 0.039 1
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0007 0.0133
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0017 0.0336
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0151 0.0063 0.2147
Loa Loa (eye worm) hypothetical protein 0.0039 0.0007 0.0044
Schistosoma mansoni cathepsin D (A01 family) 0.081 0.039 0.039
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0169 0.5973
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0019 0.0118
Plasmodium falciparum plasmepsin II 0.081 0.039 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0028 0.0002 0.0009
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.003 0.0003 0.006
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0591 0.0281 0.0682
Loa Loa (eye worm) ThiF family protein 0.0038 0.0007 0.0042
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.001 0.0244
Brugia malayi hypothetical protein 0.081 0.039 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0021 0.042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0016 0.0379
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0119 0.0047 0.0978
Leishmania major hypothetical protein, conserved 0.0591 0.0281 1
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0591 0.0281 0.0682
Loa Loa (eye worm) aspartic protease BmAsp-2 0.081 0.039 0.2608
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0041 0.0987

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.216 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
IC50 (functional) = 6.99 uM PUBCHEM_BIOASSAY: AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2006, AID2011, AID2069, AID2614, AID2658] ChEMBL. No reference
IC50 (functional) 7.25 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 10.29 uM PUBCHEM_BIOASSAY: uHTS HTRF assay for identification of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2011, AID2018, AID2069, AID2614, AID2658] ChEMBL. No reference
IC50 (functional) = 14.5 uM PUBCHEM_BIOASSAY: Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 32.9 uM PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 66.6 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.31 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: Ub-rhodamine 110 based assay for inhibitors Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.4927 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: CHOP2 Reporter Counterscreen Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 42.2841 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 46.4515 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 60.1198 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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