Detailed information for compound 1637979

Basic information

Technical information
  • TDR Targets ID: 1637979
  • Name: NCI60_002193
  • MW: 352.404 | Formula: C21H22NO4+
  • H donors: 0 H acceptors: 0 LogP: 2.83 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2CC[N+](C3c2c2c1OCc1c2c(C3)cc2c1OCO2)(C)C
  • InChi: 1S/C21H22NO4/c1-22(2)5-4-11-7-15(23-3)21-19-17-12(6-14(22)18(11)19)8-16-20(26-10-25-16)13(17)9-24-21/h7-8,14H,4-6,9-10H2,1-3H3/q+1
  • InChiKey: CIRTUANNSSIDGZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni heat shock protein 0.0049 0.0178 0.0409
Loa Loa (eye worm) serotonin transporter b 0.0014 0.0013 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0093 0.1846
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0031 0.0093 0.2657
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0105 0.0437 1
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0049 0.0178 0.0216
Trichomonas vaginalis glucosylceramidase, putative 0.0145 0.0623 0.6004
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0014 0.0014 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0105 0.0437 0.9719
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0213 0.4697
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0093 0.0229
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0018 0.0031
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0079 0.0314 1
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0049 0.0178 0.5
Giardia lamblia Heat shock protein HSP 90-alpha 0.0049 0.0178 0.5
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0033 0.0103 0.225
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0105 0.0437 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0031 0.0093 0.1846
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0105 0.0437 1
Trichomonas vaginalis glucosylceramidase, putative 0.0145 0.0623 0.6004
Entamoeba histolytica hypothetical protein 0.0064 0.0245 0.4289
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0033 0.0103 0.2082
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0049 0.0178 0.4007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0105 0.0437 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0015 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.007 0.0274 0.0663
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Trichomonas vaginalis glucosylceramidase, putative 0.0221 0.0975 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0213 0.4697
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0093 0.0229
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0103 0.2082
Onchocerca volvulus Glucosylceramidase homolog 0.0145 0.0623 1
Schistosoma mansoni hypothetical protein 0.0044 0.0154 0.0348
Loa Loa (eye worm) oxidoreductase 0.0031 0.0093 0.0217
Toxoplasma gondii propionate-CoA ligase 0.0031 0.0093 0.0499
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0213 0.1249
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0093 0.1846
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0017 0.0029 0.0334
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0073 0.018
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Schistosoma mansoni P2X receptor subunit 0.0347 0.1555 0.3812
Schistosoma mansoni hypothetical protein 0.0064 0.0245 0.0572
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0049 0.0178 0.0216
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Plasmodium vivax acyl-CoA synthetase, putative 0.0079 0.0314 1
Echinococcus multilocularis lamin 0.0027 0.0073 0.0064
Plasmodium vivax DNA topoisomerase II, putative 0.0049 0.0178 0.5506
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0093 0.1846
Loa Loa (eye worm) hypothetical protein 0.0105 0.0437 0.1065
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.031 0.1387 0.3262
Echinococcus granulosus lamin 0.0027 0.0073 0.0158
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0018 0.0032 0.0401
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0014 0.0013 0.0009
Mycobacterium ulcerans polyketide synthase 0.0023 0.0054 0.0935
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0031 0.0093 0.1846
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0093 0.1846
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.031 0.1387 0.3262
Echinococcus multilocularis Smad4 0.0015 0.0018 0.0008
Entamoeba histolytica hypothetical protein 0.0064 0.0245 0.4289
Chlamydia trachomatis DNA gyrase subunit B 0.0049 0.0178 0.5506
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0014 0.0013 0.0004
Onchocerca volvulus 0.0027 0.0073 0.0989
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0049 0.0178 0.0417
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0049 0.0178 0.5
Trypanosoma brucei DNA topoisomerase ii 0.0049 0.0178 0.0216
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0213 0.0503
Entamoeba histolytica DNA topoisomerase II, putative 0.0049 0.0178 0.2421
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0049 0.0178 0.1033
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.0093 0.1846
Onchocerca volvulus Fatty acid synthase homolog 0.0038 0.0127 0.1875
Schistosoma mansoni hypothetical protein 0.0044 0.0154 0.0348
Loa Loa (eye worm) hypothetical protein 0.0044 0.0154 0.0367
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0021 0.0048 0.079
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0049 0.0178 0.5
Mycobacterium ulcerans hypothetical protein 0.0105 0.0437 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0049 0.0178 0.0216
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0093 0.0229
Plasmodium vivax DNA gyrase subunit B, putative 0.0049 0.0178 0.5506
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0015 0.0018 0.0008
Trypanosoma cruzi heat shock protein 90, putative 0.0049 0.0178 0.0216
Loa Loa (eye worm) heat shock protein 90 0.0049 0.0178 0.0428
Mycobacterium leprae Polyketide synthase Pks13 0.0032 0.0097 0.1944
Loa Loa (eye worm) norepinephrine transporter 0.0014 0.0013 0.0019
Trypanosoma brucei developmentally regulated phosphoprotein 0.0887 0.4059 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0093 0.2019
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0213 0.0495
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0213 0.481
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0139 0.0594 0.1463
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0015 0.0018 0.0012
Plasmodium falciparum heat shock protein 90 0.0049 0.0178 0.5506
Brugia malayi AMP-binding enzyme family protein 0.0105 0.0437 0.1076
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0017 0.0029 0.0334
Mycobacterium ulcerans two component regulator - sensor kinase 0.0049 0.0178 0.3878
Schistosoma mansoni pyruvate dehydrogenase 0.0838 0.3831 0.9435
Loa Loa (eye worm) hypothetical protein 0.0079 0.0314 0.0761
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0019
Onchocerca volvulus 0.0027 0.0073 0.0989
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0093 0.1846
Schistosoma mansoni endoplasmin 0.0049 0.0178 0.0409
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0081 0.0323 0.0314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0081 0.0323 0.0766
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0021 0.0045 0.0915
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0073 0.0168
Plasmodium vivax endoplasmin, putative 0.0049 0.0178 0.5506
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0031 0.0093 0.1846
Echinococcus multilocularis sodium and chloride dependent glycine 0.007 0.0274 0.0265
Brugia malayi latrophilin 2 splice variant baaae 0.0095 0.039 0.0961
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Brugia malayi Sodium:neurotransmitter symporter family protein 0.007 0.0274 0.0674
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0049 0.0178 0.4007
Mycobacterium ulcerans acyl-CoA synthetase 0.0105 0.0437 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0015 0.0018 0.0021
Echinococcus granulosus tachykinin peptides receptor 99D 0.0193 0.0844 0.2061
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.007 0.0274 0.0663
Echinococcus granulosus geminin 0.0305 0.1362 0.3339
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0049 0.0178 0.4007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0213 0.4697
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0031 0.0093 0.0499
Echinococcus granulosus heat shock protein 0.0049 0.0178 0.0417
Trichomonas vaginalis sensor histidine kinase, putative 0.0049 0.0178 0.0971
Entamoeba histolytica acyl-coA synthetase, putative 0.0105 0.0437 0.9719
Loa Loa (eye worm) hypothetical protein 0.0079 0.0314 0.0761
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0019
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0048 0.0985
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0221 0.0975 0.2394
Echinococcus multilocularis GPCR, family 2 0.0044 0.0154 0.0144
Schistosoma mansoni Smad4 0.0015 0.0018 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0081 0.0323 0.0766
Echinococcus multilocularis heat shock protein 90 0.0049 0.0178 0.0169
Schistosoma mansoni hypothetical protein 0.0305 0.1362 0.3333
Leishmania major DNA topoisomerase ii 0.0049 0.0178 0.0216
Schistosoma mansoni intermediate filament proteins 0.0027 0.0073 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0081 0.0323 0.0766
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0016 0.0039
Toxoplasma gondii heat shock protein HSP90 0.0049 0.0178 0.1033
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0049 0.0178 0.3878
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0185 0.0455
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0014 0.0013 0.0032
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0213 0.0204
Chlamydia trachomatis DNA gyrase subunit B 0.0049 0.0178 0.5506
Schistosoma mansoni smad1 5 8 and 0.0015 0.0018 0.0012
Trypanosoma cruzi DNA topoisomerase II, putative 0.0049 0.0178 0.0216
Loa Loa (eye worm) hypothetical protein 0.0049 0.0178 0.0428
Onchocerca volvulus 0.0105 0.0437 0.6949
Brugia malayi AMP-binding enzyme family protein 0.0105 0.0437 0.1076
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Loa Loa (eye worm) hypothetical protein 0.0027 0.0073 0.0168
Schistosoma mansoni hypothetical protein 0.0044 0.0154 0.0348
Mycobacterium tuberculosis Probable two component sensor kinase 0.0049 0.0178 0.4007
Schistosoma mansoni lamin 0.0027 0.0073 0.0149
Mycobacterium ulcerans two component sensor kinase MprB 0.0049 0.0178 0.3878
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0321
Brugia malayi hypothetical protein 0.0064 0.0245 0.0602
Echinococcus multilocularis p2X purinoceptor 4 0.0347 0.1555 0.1548
Loa Loa (eye worm) hypothetical protein 0.0095 0.039 0.095
Schistosoma mansoni hypothetical protein 0.0095 0.039 0.0932
Schistosoma mansoni endoplasmin 0.0049 0.0178 0.0409
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0033 0.0103 0.2082
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0049 0.0178 0.4007
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0049 0.0178 1
Echinococcus granulosus sodium and chloride dependent glycine 0.007 0.0274 0.0653
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0221 0.0975 0.2403
Plasmodium falciparum endoplasmin, putative 0.0049 0.0178 0.5506
Mycobacterium ulcerans DNA gyrase subunit B 0.0049 0.0178 0.3878
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0049 0.0178 0.0971
Toxoplasma gondii heat shock protein 90, putative 0.0049 0.0178 0.1033
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0031 0.0093 0.0083
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Loa Loa (eye worm) hypothetical protein 0.0887 0.4059 1
Mycobacterium ulcerans thioesterase TesA 0.0018 0.0032 0.0401
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0031 0.0093 0.2019
Echinococcus multilocularis mothers against decapentaplegic 5 0.0015 0.0018 0.0008
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0049 0.0178 0.0971
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0016 0.0027
Leishmania major 4-coumarate:coa ligase-like protein 0.0105 0.0437 0.0867
Loa Loa (eye worm) hypothetical protein 0.0079 0.0314 0.0761
Trichomonas vaginalis heat shock protein, putative 0.0049 0.0178 0.0971
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0011
Trypanosoma cruzi DNA topoisomerase II, putative 0.0049 0.0178 0.0216
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0073 0.1558
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0049 0.0178 1
Brugia malayi Probable DNA topoisomerase II 0.0049 0.0178 0.044
Brugia malayi intermediate filament protein 0.0027 0.0073 0.018
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0032 0.0097 0.2115
Onchocerca volvulus 0.0136 0.0582 0.9326
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0049 0.0178 0.044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0213 0.0303
Brugia malayi MH1 domain containing protein 0.0015 0.0018 0.0044
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0049 0.0178 0.3878
Leishmania major developmentally regulated phosphoprotein-like protein 0.0887 0.4059 1
Echinococcus multilocularis p2X purinoceptor 4 0.0347 0.1555 0.1548
Brugia malayi Calcitonin receptor-like protein seb-1 0.0139 0.0594 0.1463
Loa Loa (eye worm) hypothetical protein 0.0105 0.0437 0.1065
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0178 0.0216
Trichomonas vaginalis glucosylceramidase, putative 0.0145 0.0623 0.6004
Schistosoma mansoni hypothetical protein 0.0305 0.1362 0.3333
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0294 0.6683
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0021 0.0048 0.0985
Entamoeba histolytica heat shock protein 90, putative 0.0049 0.0178 0.2421
Leishmania major 4-coumarate:coa ligase-like protein 0.0105 0.0437 0.0867
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0014 0.0013 0.0004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0064 0.0245 0.0581
Plasmodium falciparum DNA gyrase subunit B 0.0049 0.0178 0.5506
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0015 0.0021 0.0342
Echinococcus granulosus serotonin transporter 0.0014 0.0013 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0044 0.0154 0.0378
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0031 0.0093 0.1846
Brugia malayi heat shock protein 90 0.0049 0.0178 0.044
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0049 0.0178 0.4007
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0014 0.0013 0.0009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0073 0.0168
Echinococcus granulosus intermediate filament protein 0.0027 0.0073 0.0158
Brugia malayi Smad1 0.0015 0.0018 0.0044
Schistosoma mansoni P2X receptor subunit 0.0347 0.1555 0.3812
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0887 0.4059 1
Trypanosoma brucei heat shock protein 90, putative 0.0049 0.0178 0.0216
Onchocerca volvulus 0.0033 0.0103 0.1473
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0021 0.0048 0.079
Mycobacterium ulcerans thioesterase 0.0018 0.0032 0.0401
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0019
Echinococcus multilocularis lamin dm0 0.0027 0.0073 0.0064
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0033 0.0103 0.2082
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0023 0.0054 0.0935
Trichomonas vaginalis glucosylceramidase, putative 0.0145 0.0623 0.6004
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0031 0.0093 0.2019
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Loa Loa (eye worm) hypothetical protein 0.0136 0.0582 0.1422
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0021 0.0048 0.0119
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0049 0.0178 0.1033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0081 0.0323 0.0774
Brugia malayi hypothetical protein 0.0136 0.0582 0.1433
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0031 0.0093 0.0499
Leishmania major mitochondrial DNA topoisomerase II 0.0049 0.0178 0.0216
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.031 0.1387 0.3262
Trichomonas vaginalis endoplasmin, putative 0.0049 0.0178 0.0971
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0017 0.003 0.0569
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0178 0.0216
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0044 0.0154 0.0367
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0049 0.0178 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0221 0.0975 1
Trichomonas vaginalis glucosylceramidase, putative 0.0221 0.0975 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0049 0.0178 0.4007
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0031 0.0093 0.1846
Entamoeba histolytica hypothetical protein 0.0064 0.0245 0.4289
Echinococcus multilocularis serotonin transporter 0.0014 0.0013 0.0004
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0093 0.2019
Schistosoma mansoni smad 0.0015 0.0018 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.0314 0.7082
Loa Loa (eye worm) hypothetical protein 0.0079 0.0314 0.0761
Trichomonas vaginalis heat shock protein, putative 0.0049 0.0178 0.0971
Trypanosoma brucei Heat shock protein 83, putative 0.0049 0.0178 0.0216
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0044 0.0154 0.0144
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0017 0.0029 0.0334
Loa Loa (eye worm) Smad1 0.0015 0.0018 0.0031
Mycobacterium leprae Probable two-component sensor kinase 0.0049 0.0178 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0145 0.0623 0.6004
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0049 0.0178 0.5506
Loa Loa (eye worm) hypothetical protein 0.0026 0.0071 0.0163
Schistosoma mansoni smad1 5 8 and 0.0015 0.0018 0.0012
Onchocerca volvulus 0.0051 0.0185 0.2817
Trypanosoma brucei heat shock protein, putative 0.0049 0.0178 0.0216
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0081 0.0323 0.0784
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0023 0.0054 0.0935
Loa Loa (eye worm) MH2 domain-containing protein 0.0215 0.0946 0.2321
Brugia malayi MH1 domain containing protein 0.0015 0.0018 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0081 0.0323 0.0774
Loa Loa (eye worm) hypothetical protein 0.0105 0.0437 0.1065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0294 0.6683
Loa Loa (eye worm) TOPoisomerase family member 0.0049 0.0178 0.0428
Echinococcus multilocularis p2X purinoceptor 4 0.0347 0.1555 0.1548
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0049 0.0178 0.3878
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0023 0.0054 0.1127
Leishmania major hypothetical protein, conserved 0.0049 0.0178 0.0216
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0049 0.0178 0.4007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.0093 0.0217
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0049 0.0178 0.2715
Trypanosoma brucei heat shock protein, putative 0.0049 0.0178 0.0216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0019
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0031 0.0093 0.0206
Trichomonas vaginalis receptor histidine kinase, putative 0.0049 0.0178 0.0971
Loa Loa (eye worm) hypothetical protein 0.0139 0.0594 0.1452
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0021 0.0048 0.0985
Loa Loa (eye worm) transcription factor SMAD2 0.0215 0.0946 0.2321
Mycobacterium ulcerans acyl-CoA synthetase 0.0105 0.0437 1
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0049 0.0178 0.3878
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0049 0.0178 0.0216
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0014 0.0013 0.0032
Schistosoma mansoni pyruvate dehydrogenase 0.0887 0.4059 1
Brugia malayi MH2 domain containing protein 0.0015 0.0018 0.0044
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0049 0.0178 0.0971
Onchocerca volvulus 0.0031 0.0093 0.131
Toxoplasma gondii DNA topoisomerase 2, putative 0.0049 0.0178 0.1033
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0049 0.0178 0.0169
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0093 0.2019
Trypanosoma brucei heat shock protein, putative 0.0049 0.0178 0.0216
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0074 0.0383
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0044 0.0154 0.0356
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0033 0.0103 0.225
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0014 0.0013 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0105 0.0437 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0023 0.0054 0.1127
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.031 0.1387 0.8573
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.036 0.1615 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0033 0.0103 0.2082
Mycobacterium tuberculosis Conserved protein 0.0049 0.0178 0.4007
Echinococcus multilocularis musashi 0.0027 0.0073 0.0064
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0049 0.0178 0.4007
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0213 0.0495
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0049 0.0178 0.4007
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0049 0.0178 0.3878
Plasmodium vivax heat shock protein 86, putative 0.0049 0.0178 0.5506
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0014 0.0013 0.0019
Schistosoma mansoni sodium/chloride dependent transporter 0.007 0.0274 0.0645
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0049 0.0178 0.4007
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0193 0.0844 0.0836
Loa Loa (eye worm) fatty acid synthase 0.0021 0.0047 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0019
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0023 0.0054 0.0935
Mycobacterium ulcerans putative regultory protein 0.0049 0.0178 0.3878
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0021 0.0045 0.0915
Echinococcus granulosus Smad4 0.0015 0.0018 0.0021
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0178 0.0216
Schistosoma mansoni hypothetical protein 0.0044 0.0154 0.0348
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0049 0.0178 0.5506
Echinococcus granulosus p2X purinoceptor 4 0.0347 0.1555 0.3818
Schistosoma mansoni P2X receptor subunit 0.0347 0.1555 0.3812
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0049 0.0178 0.0971
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0178 0.5506
Echinococcus granulosus heat shock protein 90 0.0049 0.0178 0.0417
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0887 0.4059 0.4054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0139 0.0594 0.1452
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0033 0.0103 0.225
Trichomonas vaginalis DNA topoisomerase II, putative 0.0049 0.0178 0.0971
Leishmania major 4-coumarate:coa ligase-like protein 0.0105 0.0437 0.0867
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0049 0.0178 0.2715
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Echinococcus granulosus p2X purinoceptor 4 0.0347 0.1555 0.3818
Plasmodium vivax acetyl-CoA synthetase, putative 0.0031 0.0093 0.2657
Plasmodium falciparum acyl-CoA synthetase 0.0079 0.0314 1
Mycobacterium ulcerans polyketide synthase 0.0021 0.0048 0.079
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0049 0.0178 0.3878
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0049 0.0178 0.0971
Mycobacterium ulcerans Type I modular polyketide synthase 0.0021 0.0048 0.079
Mycobacterium ulcerans Type I modular polyketide synthase 0.0021 0.0048 0.079
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0032 0.0097 0.2115
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0031 0.0093 0.0229
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0105 0.0437 0.1076
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0049 0.0178 0.2715
Trichomonas vaginalis glucosylceramidase, putative 0.0153 0.0659 0.6415
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0014 0.0013 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0221 0.0975 1
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Echinococcus granulosus smad 0.0015 0.0018 0.0021
Schistosoma mansoni P2X receptor subunit 0.0347 0.1555 0.3812
Schistosoma mansoni lamin 0.0027 0.0073 0.0149
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0014 0.0013 0.0032
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0023 0.0054 0.1127
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0021 0.0048 0.079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.0437 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0294 0.6683
Mycobacterium ulcerans Type I modular polyketide synthase 0.0021 0.0048 0.079
Loa Loa (eye worm) endoplasmin 0.0049 0.0178 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0221 0.0975 1
Trypanosoma cruzi heat shock protein 90, putative 0.0049 0.0178 0.0216
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0049 0.0178 0.3878
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Echinococcus granulosus lamin dm0 0.0027 0.0073 0.0158
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0051 0.0185 0.4153
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0051 0.0185 0.0443
Entamoeba histolytica hypothetical protein 0.0064 0.0245 0.4289
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0049 0.0178 0.0216
Onchocerca volvulus 0.0068 0.0264 0.4118
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0018 0.0031
Trypanosoma cruzi Heat shock protein 83, putative 0.0049 0.0178 0.0216
Schistosoma mansoni sodium/chloride dependent transporter 0.007 0.0274 0.0645
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0887 0.4059 1
Entamoeba histolytica heat shock protein 90, putative 0.0049 0.0178 0.2421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0294 0.6683
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0081 0.0323 0.0795
Schistosoma mansoni heat shock protein 0.0049 0.0178 0.0409
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0105 0.0437 1
Giardia lamblia Pms1-like protein 0.0049 0.0178 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0093 0.1846
Echinococcus multilocularis sodium and chloride dependent glycine 0.007 0.0274 0.0265
Brugia malayi Latrophilin receptor protein 2 0.0044 0.0154 0.0378
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0217
Loa Loa (eye worm) hypothetical protein 0.0049 0.0178 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0153 0.0659 0.6415
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0093 0.2019
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0079 0.0314 0.7144
Plasmodium falciparum DNA topoisomerase 2 0.0049 0.0178 0.5506
Echinococcus granulosus p2X purinoceptor 4 0.0347 0.1555 0.3818
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0093 0.1846
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0064 0.0245 0.0235
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0023 0.0054 0.0935
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0033 0.0103 0.0253
Loa Loa (eye worm) hypothetical protein 0.0079 0.0314 0.0761
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0217
Trypanosoma brucei heat shock protein, putative 0.0049 0.0178 0.0216
Schistosoma mansoni DNA topoisomerase II 0.0049 0.0178 0.0409
Mycobacterium leprae Probable polyketide synthase Pks1 0.0023 0.0054 0.0935
Brugia malayi MH2 domain containing protein 0.0015 0.0018 0.0044
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0049 0.0178 0.4007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0044 0.0154 0.0356
Echinococcus multilocularis smad 0.0015 0.0018 0.0008
Trypanosoma brucei heat shock protein 90, putative 0.0049 0.0178 0.0216
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0105 0.0437 1
Trypanosoma brucei heat shock protein, putative 0.0049 0.0178 0.0216
Mycobacterium leprae Probable two component sensor kinase MprB 0.0049 0.0178 0.3878
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0033 0.0103 0.225
Brugia malayi hypothetical protein 0.0014 0.0013 0.0032
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0014 0.0013 0.0009
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0049 0.0178 0.0216
Echinococcus multilocularis heat shock protein 0.0049 0.0178 0.0169
Echinococcus granulosus GPCR family 2 0.0044 0.0154 0.0356
Schistosoma mansoni acetyl-CoA synthetase 0.0031 0.0093 0.0197
Loa Loa (eye worm) hypothetical protein 0.007 0.0274 0.0663
Trichomonas vaginalis glucosylceramidase, putative 0.0145 0.0623 0.6004
Loa Loa (eye worm) solute carrier family 6 member 4 0.0014 0.0013 0.0019
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0033 0.0103 0.2082
Echinococcus multilocularis geminin 0.0305 0.1362 0.1353
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0049 0.0178 0.044
Mycobacterium tuberculosis Probable thioesterase TesA 0.0018 0.0032 0.0605
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0044 0.0154 0.0144
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0105 0.0437 1
Schistosoma mansoni transcription factor LCR-F1 0.0064 0.0245 0.0572
Echinococcus granulosus sodium and chloride dependent glycine 0.007 0.0274 0.0653
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0014 0.0013 0.0032
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0887 0.4059 0.4054
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.004 0.0136 0.0336
Mycobacterium tuberculosis Possible two component sensor kinase 0.0049 0.0178 0.4007
Brugia malayi kinase, mitochondrial precursor 0.0887 0.4059 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0107 0.0447 1
Leishmania major heat shock protein 83-1 0.0049 0.0178 0.0216
Toxoplasma gondii type I fatty acid synthase, putative 0.0015 0.002 0.0044
Brugia malayi Endoplasmin precursor 0.0049 0.0178 0.044
Trichomonas vaginalis receptor histidine kinase, putative 0.0049 0.0178 0.0971
Schistosoma mansoni pyruvate dehydrogenase 0.0838 0.3831 0.9435
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0019 0.0041
Mycobacterium ulcerans acetyl-CoA synthetase 0.0031 0.0093 0.1846
Trichomonas vaginalis glucosylceramidase, putative 0.0145 0.0623 0.6004
Trypanosoma brucei heat shock protein, putative 0.0049 0.0178 0.0216
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0049 0.0178 0.3878
Mycobacterium ulcerans polyketide synthase Pks13 0.0032 0.0097 0.1944
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0049 0.0178 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0221 0.0975 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0081 0.0323 0.0314
Trypanosoma brucei heat shock protein, putative 0.0049 0.0178 0.0216
Brugia malayi MH2 domain containing protein 0.0215 0.0946 0.233
Trypanosoma brucei heat shock protein, putative 0.0049 0.0178 0.0216
Schistosoma mansoni smad1 5 8 and 0.0015 0.0018 0.0012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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