Detailed information for compound 1648783

Basic information

Technical information
  • TDR Targets ID: 1648783
  • Name: N-[(2-bromo-5-hydroxyphenyl)methylideneamino] pyridine-3-carboxamide
  • MW: 320.141 | Formula: C13H10BrN3O2
  • H donors: 2 H acceptors: 3 LogP: 2.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(c(c1)/C=N/NC(=O)c1cccnc1)Br
  • InChi: 1S/C13H10BrN3O2/c14-12-4-3-11(18)6-10(12)8-16-17-13(19)9-2-1-5-15-7-9/h1-8,18H,(H,17,19)/b16-8+
  • InChiKey: DVESYZFNOVQPBZ-LZYBPNLTSA-N  


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Synonyms

  • N-[(2-bromo-5-hydroxy-phenyl)methyleneamino]pyridine-3-carboxamide
  • N-[(2-bromo-5-hydroxyphenyl)methyleneamino]-3-pyridinecarboxamide
  • N-[(2-bromo-5-hydroxy-benzylidene)amino]nicotinamide
  • N-[(2-bromo-5-hydroxy-phenyl)methylideneamino]pyridine-3-carboxamide
  • BAS 00239931
  • Nicotinic acid (2-bromo-5-hydroxy-benzylidene)-hydrazide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens Kruppel-like factor 5 (intestinal) Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0017 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0041 0.3402
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0021 0.0087
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0135 0.1484
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0163 0.1788
Echinococcus multilocularis transcription factor btf3 0.0042 0.0076 0.031
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0034 0.0086
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0041 0.0073 0.0805
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0076 0.0242
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0135 0.0552
Loa Loa (eye worm) hypothetical protein 0.0085 0.0186 0.2036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0109 0.1197
Echinococcus granulosus snurportin 1 0.0372 0.0912 1
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0115 0.0469
Brugia malayi RNA, U transporter 1 0.0099 0.022 0.0303
Loa Loa (eye worm) hypothetical protein 0.0049 0.0094 0.1029
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0115 0.1263
Trypanosoma cruzi ISWI complex protein 0.0018 0.0016 0.0019
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0046 0.0131
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0109 0.015
Entamoeba histolytica Ran family GTPase 0.0026 0.0034 0.0892
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0034 0.0373
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0046 0.0131
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0046 0.0131
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.019
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0024
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0024
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0076 0.2513
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0135 0.1484
Trichomonas vaginalis ran, putative 0.0026 0.0034 0.2646
Onchocerca volvulus 0.0182 0.0432 0.0432
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0163 0.1788
Loa Loa (eye worm) hypothetical protein 0.0066 0.0135 0.1484
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0034 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0163 0.1788
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0109 0.1197
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0023 0.0254
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0122 0.1335
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0254
Brugia malayi hypothetical protein 0.002 0.0019 0.0026
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0076 0.0242
Loa Loa (eye worm) hypothetical protein 0.0058 0.0115 0.1263
Schistosoma mansoni patched 1 0.0051 0.0098 0.108
Brugia malayi PHD-finger family protein 0.0032 0.005 0.0069
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0115 0.1263
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0163 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0098 1
Brugia malayi CHE-14 protein 0.0051 0.0098 0.0136
Brugia malayi Bromodomain containing protein 0.0093 0.0204 0.0281
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0017 0.0071
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0098 0.0401
Brugia malayi isocitrate dehydrogenase 0.0019 0.0017 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0017 0.019
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0115 0.1263
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0076 0.7452
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0076 0.7452
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0017 0.0071
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0017 0.0071
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0023 0.0254
Leishmania major GTP-binding protein, putative 0.0026 0.0034 0.0086
Echinococcus multilocularis expressed conserved protein 0.0112 0.0252 0.1029
Brugia malayi beta-NAC-like protein 0.0042 0.0076 0.0105
Schistosoma mansoni zinc finger protein 0.0018 0.0016 0.0174
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0115 0.1263
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0271 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0057 0.0172
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0271 0.2967
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0046 0.0131
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0163 0.0225
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0021 0.0233
Leishmania major hypothetical protein, conserved 0.003 0.0046 0.0131
Chlamydia trachomatis DNA polymerase I 0.0057 0.0114 0.5
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0135 0.0187
Brugia malayi Bromodomain containing protein 0.0046 0.0086 0.0119
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0017 0.0071
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0004 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0109 0.1197
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0109 0.0445
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0057 0.0172
Onchocerca volvulus 0.0035 0.0057 0.0057
Schistosoma mansoni zinc finger protein 0.0026 0.0034 0.0373
Plasmodium falciparum importin beta, putative 0.0035 0.0057 0.0172
Loa Loa (eye worm) hypothetical protein 0.0182 0.0432 0.4736
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0076 0.7452
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0109 0.1197
Loa Loa (eye worm) RNA binding protein 0.0076 0.0163 0.1788
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0034 0.0373
Loa Loa (eye worm) hypothetical protein 0.006 0.0122 0.1335
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0034 0.0086
Schistosoma mansoni transcription factor btf3 0.0042 0.0076 0.0835
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0271 0.1103
Brugia malayi TAR-binding protein 0.0076 0.0163 0.0225
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0057 0.0625
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0098 0.108
Schistosoma mansoni hypothetical protein 0.0041 0.0073 0.0805
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0163 0.1788
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0034 0.0086
Echinococcus granulosus transcription factor btf3 0.0042 0.0076 0.0835
Brugia malayi hypothetical protein 0.0182 0.0432 0.0595
Schistosoma mansoni hypothetical protein 0.0049 0.0094 0.1028
Leishmania major hypothetical protein, conserved 0.0018 0.0016 0.0019
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0057 0.0234
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0507
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0004 0.0015
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.108 0.2709 1
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.004 0.0072 0.0225
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.004 0.0072 0.0225
Leishmania major telomerase reverse transcriptase, putative 0.108 0.2709 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0017 0.0191
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0017 0.0024
Brugia malayi mbt repeat family protein 0.0058 0.0115 0.0159
Brugia malayi Telomerase reverse transcriptase 0.2874 0.726 1
Schistosoma mansoni cpg binding protein 0.0039 0.0068 0.0744
Schistosoma mansoni ran 0.0026 0.0034 0.0373
Treponema pallidum DNA polymerase I (polA) 0.0057 0.0114 0.5
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0271 0.0373
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.108 0.2709 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0021 0.0233
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0071
Schistosoma mansoni hypothetical protein 0.035 0.0857 0.94
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0017 0.019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0041 0.3402
Entamoeba histolytica hypothetical protein 0.0042 0.0076 0.2513
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0034 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0109 0.0445
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0057 0.0114 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0157 0.1721
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.019
Loa Loa (eye worm) hypothetical protein 0.0053 0.0105 0.1148
Loa Loa (eye worm) hypothetical protein 0.0062 0.0128 0.1399
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0043 0.0473
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.002 0.0019 0.0031
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0115 0.0469
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0021 0.0233
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.108
Echinococcus granulosus tar DNA binding protein 0.0076 0.0163 0.1788
Brugia malayi RNA binding protein 0.0076 0.0163 0.0225
Toxoplasma gondii RNA-directed DNA polymerase 0.108 0.2709 1
Echinococcus granulosus cpg binding protein 0.0039 0.0068 0.0744
Brugia malayi CXXC zinc finger family protein 0.0035 0.0057 0.0079
Schistosoma mansoni importin beta-1 0.0035 0.0057 0.0629
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0275 0.3019
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0545 0.5974
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0076 0.0242
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0122 0.0168
Brugia malayi Importin beta-1 subunit 0.0035 0.0057 0.0079
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.019
Schistosoma mansoni hypothetical protein 0.0372 0.0912 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0109 0.1197
Leishmania major basic transcription factor 3a, putative 0.0042 0.0076 0.0242
Loa Loa (eye worm) hypothetical protein 0.0119 0.0271 0.2967
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0076 0.0242
Trypanosoma brucei ISWI complex protein 0.0018 0.0016 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0163 0.1788
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0119
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0057 0.0172
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0079 0.0867
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0143 0.049
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.004 0.0072 0.0225
Schistosoma mansoni hypothetical protein 0.0049 0.0094 0.1028
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0912 1
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.004 0.0072 0.0225
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0076 0.0242
Mycobacterium ulcerans DNA polymerase I 0.0057 0.0114 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0073 0.0101
Echinococcus granulosus GPCR family 2 0.0019 0.0017 0.019
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.019
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0115 0.1263
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0191
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0017 0.0024
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0115 0.1263
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0949
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0041 0.3402
Leishmania major importin beta-1 subunit, putative 0.0028 0.0041 0.011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0017 0.019
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0046 0.0131
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0034 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0109 0.1197
Echinococcus multilocularis snurportin 1 0.0372 0.0912 0.3718
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0017 0.0024
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0057 0.0114 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.04 0.4387
Schistosoma mansoni hypothetical protein 0.0025 0.0032 0.0354
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0034 0.0086
Schistosoma mansoni cpg binding protein 0.0035 0.0057 0.0625
Entamoeba histolytica hypothetical protein 0.0028 0.0041 0.1147
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0043 0.0176
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0156 0.1707
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0076 0.0835
Brugia malayi hypothetical protein 0.003 0.0046 0.0064
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0135 0.0552
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0023 0.0254
Brugia malayi DNA polymerase I family protein 0.0016 0.0011 0.0015
Giardia lamblia Telomerase catalytic subunit 0.108 0.2709 1
Onchocerca volvulus 0.0058 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0049 0.0094 0.1028
Echinococcus granulosus expressed conserved protein 0.0112 0.0252 0.2767
Echinococcus granulosus importin subunit beta 1 0.0035 0.0057 0.0629
Echinococcus granulosus zinc finger protein 0.0026 0.0034 0.0373
Echinococcus multilocularis GPCR, family 2 0.0019 0.0017 0.0071
Echinococcus multilocularis protein patched 0.0051 0.0098 0.0401
Schistosoma mansoni hypothetical protein 0.0014 0.0004 0.004
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0057 0.0114 0.5
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0018 0.0016 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0163 0.1788
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0157 0.064
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0046 0.0131
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0032 0.0354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0023 0.0254
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.0039 0.0068 0.0744
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0079 0.0322
Brugia malayi mbt repeat family protein 0.0058 0.0115 0.0159
Schistosoma mansoni hypothetical protein 0.0049 0.0094 0.1028
Echinococcus multilocularis protein dispatched 1 0.0058 0.0117 0.0476
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0023 0.0095
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0545 0.2221
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0163 0.1788
Schistosoma mansoni ran 0.0026 0.0034 0.0373
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.004 0.0072 0.0225
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0017 0.0191
Loa Loa (eye worm) hypothetical protein 0.0035 0.0057 0.0629
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0135 0.1484
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0071
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0017 0.0024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2453 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0034 0.0047
Echinococcus multilocularis zinc finger protein 0.0026 0.0034 0.0139
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0043 0.0473
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0017 0.0024
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0098 0.108
Plasmodium falciparum telomerase reverse transcriptase 0.108 0.2709 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0098 0.108
Plasmodium vivax telomerase reverse transcriptase, putative 0.108 0.2709 1
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.004 0.0072 0.5646
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0046 0.0131
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.004 0.0072 0.0225
Loa Loa (eye worm) MBCTL1 0.0066 0.0135 0.1484
Plasmodium vivax importin-beta 2, putative 0.0035 0.0057 0.0172
Trypanosoma brucei telomerase reverse transcriptase 0.108 0.2709 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0024
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0041 0.011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0017 0.0024
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0076 0.0242
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0122 0.0168
Schistosoma mansoni DNA polymerase I 0.0016 0.0011 0.0119
Echinococcus multilocularis cpg binding protein 0.0039 0.0068 0.0277
Trypanosoma cruzi ISWI complex protein 0.0018 0.0016 0.0019
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.04 0.1631
Schistosoma mansoni bromodomain containing protein 0.0078 0.0168 0.1841

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.877 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
IC50 (functional) = 1.708 um PUBCHEM_BIOASSAY: Luminescence-based dose response cell-based high throughput screening assay for inhibitors of kruppel-like factor 5 (KLF5). (Class of assay: confirmatory) [Related pubchem assays: 1700 (Primary screen.), 1834 (Confirmation screen.), 1905 (Counterscreen.), 1858 (Summary AID.)] ChEMBL. No reference
IC50 (functional) 6.355 uM PUBCHEM_BIOASSAY: Discovery of Small Molecule Probes for H1N1 Influenza NS1A. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504399] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1714 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8024 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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