Detailed information for compound 1656950

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.388 | Formula: C22H16N4O2
  • H donors: 1 H acceptors: 4 LogP: 3.39 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1cn(c2c1cccc2)c1cncc(n1)n1ccc2c1cccc2
  • InChi: 1S/C22H16N4O2/c27-22(28)11-16-14-26(19-8-4-2-6-17(16)19)21-13-23-12-20(24-21)25-10-9-15-5-1-3-7-18(15)25/h1-10,12-14H,11H2,(H,27,28)
  • InChiKey: ZDYCIJOYVRTEPT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.0127 0.1202
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0191 0.1416
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0093 0.0124
Trypanosoma cruzi beta tubulin, putative 0.0147 0.0469 0.173
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0003 0.0018
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0093 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.0127 0.0171
Plasmodium falciparum alpha tubulin 1 0.0273 0.09 0.3321
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0802 0.2708 1
Brugia malayi ecdysone receptor 0.0022 0.0043 0.0054
Echinococcus multilocularis protein dispatched 1 0.0053 0.0148 0.0252
Echinococcus multilocularis nibrin 0.0011 0.0004 0.0006
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.1125
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0004 0.0012
Brugia malayi nuclear receptor RXR 0.0022 0.0043 0.0054
Schistosoma mansoni tubulin subunit delta 0.0064 0.0185 0.1375
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0518
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.153
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0111 0.0409
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0336 0.0458
Leishmania major beta tubulin 0.0147 0.0469 0.173
Leishmania major beta tubulin 0.0147 0.0469 0.173
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.09 1
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0043 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.0127 0.0171
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.0127 0.0941
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.09 1
Brugia malayi TAR-binding protein 0.007 0.0206 0.0279
Loa Loa (eye worm) hypothetical protein 0.0047 0.0127 0.1202
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.0185 0.0681
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0179 0.0578 0.0792
Mycobacterium ulcerans dehydrogenase 0.0042 0.0111 0.0549
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0765
Leishmania major beta tubulin 0.0147 0.0469 0.173
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0041 0.0301
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0003 0.0004
Onchocerca volvulus 0.0042 0.0111 0.0108
Brugia malayi Tubulin gamma chain 0.0147 0.0469 0.0642
Loa Loa (eye worm) hypothetical protein 0.0099 0.0305 0.2921
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0004 0.0006
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0209 0.0682 0.6558
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0557 0.187 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0064 0.0185 0.203
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0003 0.0018
Echinococcus multilocularis tubulin alpha chain 0.0273 0.09 0.1544
Schistosoma mansoni tubulin subunit alpha 0.0273 0.09 0.6706
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0003 0.0004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.0127 0.0941
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0111 0.0409
Schistosoma mansoni coup transcription factor 0.0047 0.0127 0.0941
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0056 0.0274
Loa Loa (eye worm) hypothetical protein 0.0047 0.0127 0.1202
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0003 0.0004
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0469 0.3494
Schistosoma mansoni hypothetical protein 0.0049 0.0136 0.1007
Trichomonas vaginalis tubulin, putative 0.0083 0.0251 0.2767
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.0127 0.0171
Brugia malayi ecdysteroid receptor 0.0047 0.0127 0.0171
Loa Loa (eye worm) tubulin beta chain 0.0064 0.0185 0.1764
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0463 0.445
Schistosoma mansoni ran 0.0022 0.0041 0.0301
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.05 0.0684
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.0127 0.0941
Schistosoma mansoni hypothetical protein 0.0049 0.0136 0.1007
Brugia malayi photoreceptor-specific nuclear receptor 0.0047 0.0127 0.0171
Chlamydia trachomatis DNA ligase 0.0011 0.0004 0.0009
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0312 0.1033 0.3813
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0056 0.2865
Toxoplasma gondii alpha-tubulin I, putative 0.0273 0.09 0.3321
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.09 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0056 0.0204
Plasmodium falciparum multidrug resistance protein 1 0.0011 0.0003 0.0009
Leishmania major beta tubulin 0.0147 0.0469 0.173
Loa Loa (eye worm) hypothetical protein 0.0047 0.0127 0.1202
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.0127 0.1202
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0475
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.05 0.0684
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0312 0.1033 0.3813
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0041 0.0149
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.0127 0.0941
Echinococcus multilocularis beta tubulin 0.0147 0.0469 0.0804
Entamoeba histolytica P-glycoprotein-2, putative 0.0011 0.0003 0.0026
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.1341 0.2302
Loa Loa (eye worm) hypothetical protein 0.019 0.0616 0.5921
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0469 0.0804
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0336 0.2498
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.0374
Brugia malayi alpha-tubulin 0.0273 0.09 0.1236
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Trypanosoma brucei epsilon tubulin 0.0147 0.0469 0.173
Schistosoma mansoni hypothetical protein 0.0314 0.1038 0.774
Schistosoma mansoni patched 1 0.0046 0.0125 0.0929
Schistosoma mansoni transient receptor potential channel 0.0065 0.0191 0.1416
Onchocerca volvulus 0.0179 0.0578 0.0575
Giardia lamblia Beta tubulin 0.0147 0.0469 0.1733
Echinococcus multilocularis thyroid hormone receptor alpha 0.0047 0.0127 0.0217
Brugia malayi hypothetical protein 0.0011 0.0004 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.003 0.0144
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0191 0.0326
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0068 0.0247
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0056 0.2865
Plasmodium falciparum telomerase reverse transcriptase 0.0802 0.2708 1
Plasmodium falciparum alpha tubulin 2 0.0273 0.09 0.3321
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0191 0.0326
Brugia malayi nuclear receptor NHR-67 0.0022 0.0043 0.0054
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.153
Toxoplasma gondii histone lysine-specific demethylase 0.0042 0.0111 0.0409
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.09 0.6706
Loa Loa (eye worm) hypothetical protein 0.0046 0.0125 0.1187
Echinococcus granulosus beta tubulin 0.0147 0.0469 0.3494
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.0127 0.0217
Schistosoma mansoni tubulin subunit beta 0.0147 0.0469 0.3494
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0469 0.3494
Echinococcus multilocularis cpg binding protein 0.003 0.0069 0.0118
Echinococcus multilocularis tubulin alpha 3 chain 0.0273 0.09 0.1544
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0056 0.0283
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0458 0.1689
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.1052
Loa Loa (eye worm) TAR-binding protein 0.007 0.0206 0.1964
Onchocerca volvulus 0.0022 0.0043 0.0039
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0047 0.0127 0.0941
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0002 0.0003
Giardia lamblia Gamma tubulin 0.0147 0.0469 0.1733
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0273 0.09 1
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.1004 0.3706
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0127 0.0171
Brugia malayi nuclear hormone receptor 0.0047 0.0127 0.0171
Loa Loa (eye worm) tubulin gamma chain 0.0147 0.0469 0.4505
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0043 0.0054
Leishmania major beta tubulin 0.0147 0.0469 0.173
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0113 0.0415
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0007
Loa Loa (eye worm) tubulin alpha-3 chain 0.019 0.0616 0.5921
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0312 0.1033 0.5518
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.0127 0.0171
Entamoeba histolytica hypothetical protein 0.0011 0.0004 0.0037
Leishmania major beta tubulin 0.0147 0.0469 0.173
Brugia malayi Common central domain of tyrosinase family protein 0.0179 0.0578 0.0792
Entamoeba histolytica tubulin family protein 0.0147 0.0469 0.521
Trichomonas vaginalis tubulin, putative 0.0064 0.0185 0.203
Schistosoma mansoni hypothetical protein 0.0049 0.0136 0.1007
Echinococcus multilocularis tubulin subunit beta 0.0147 0.0469 0.0804
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0042 0.0111 0.0549
Toxoplasma gondii hypothetical protein 0.0049 0.0134 0.0494
Schistosoma mansoni hypothetical protein 0.0045 0.012 0.0887
Brugia malayi tailless protein 0.0022 0.0043 0.0054
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0111 0.058
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0003 0.0004
Brugia malayi hypothetical protein 0.0017 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Loa Loa (eye worm) hypothetical protein 0.0209 0.0682 0.6558
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0043 0.0054
Echinococcus multilocularis tubulin gamma 1 chain 0.0147 0.0469 0.0804
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.09 0.6706
Leishmania major gamma-tubulin 0.0147 0.0469 0.173
Trichomonas vaginalis tubulin, putative 0.0083 0.0251 0.2767
Echinococcus granulosus tubulin alpha chain 0.0273 0.09 0.6706
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0127 0.0171
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0043 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0125 0.1363
Trichomonas vaginalis tubulin epsilon chain, putative 0.0273 0.09 1
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.0127 0.0217
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.1004 0.3706
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.003 0.0144
Trypanosoma brucei alpha tubulin 0.0273 0.09 0.3321
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0004 0.0012
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0004 0.0025
Echinococcus multilocularis tubulin alpha chain 0.0273 0.09 0.1544
Loa Loa (eye worm) hypothetical protein 0.0156 0.05 0.48
Plasmodium vivax tubulin gamma chain, putative 0.0147 0.0469 0.173
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0043 0.0039
Schistosoma mansoni hypothetical protein 0.0039 0.0102 0.0754
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0004 0.0001
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0093 0.0687
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0041 0.0149
Trichomonas vaginalis tubulin gamma chain, putative 0.0147 0.0469 0.5197
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0003 0.0004
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0043 0.0312
Echinococcus multilocularis beta tubulin 0.0147 0.0469 0.0804
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.1125
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0312 0.1033 0.5128
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0056 0.0073
Echinococcus multilocularis tubulin alpha 1C chain 0.0273 0.09 0.1544
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0042 0.0111 0.0409
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0068 0.0247
Trypanosoma brucei telomerase reverse transcriptase 0.0802 0.2708 1
Trichomonas vaginalis tubulin beta chain, putative 0.0147 0.0469 0.5197
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0136 0.1287
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0068 0.0115
Echinococcus multilocularis tar DNA binding protein 0.007 0.0206 0.0352
Echinococcus granulosus tubulin alpha chain 0.0273 0.09 0.6706
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0179 0.0578 0.0792
Echinococcus multilocularis expressed conserved protein 0.0101 0.0313 0.0537
Echinococcus multilocularis tubulin alpha 1C chain 0.0273 0.09 0.1544
Schistosoma mansoni alpha tubulin 0.0273 0.09 0.6706
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0002 0.0012
Onchocerca volvulus 0.0011 0.0004 0.0001
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0043 0.0312
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0064 0.0592
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0056 0.0614
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0147 0.0469 0.173
Schistosoma mansoni tyrosinase precursor 0.0179 0.0578 0.4304
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0011
Echinococcus granulosus tar DNA binding protein 0.007 0.0206 0.153
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0043 0.0312
Leishmania major beta tubulin 0.0147 0.0469 0.173
Echinococcus multilocularis snurportin 1 0.0314 0.1038 0.1782
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0004 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0127 0.0941
Echinococcus granulosus tubulin alpha 0.0147 0.0469 0.3494
Loa Loa (eye worm) tubulin beta-1 chain 0.0147 0.0469 0.4505
Trypanosoma cruzi alpha tubulin, putative 0.0273 0.09 0.3321
Treponema pallidum cell division protein FtsZ 0.0064 0.0185 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0055 0.02
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0044 0.0117 0.043
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0127 0.0941
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0127 0.0941
Schistosoma mansoni alpha tubulin 0.0273 0.09 0.6706
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Echinococcus multilocularis tubulin alpha 0.0147 0.0469 0.0804
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0055 0.02
Onchocerca volvulus 0.0026 0.0056 0.0053
Trypanosoma cruzi zeta tubulin, putative 0.0064 0.0185 0.0681
Echinococcus granulosus peroxisome assembly protein 26 0.0273 0.09 0.6706
Onchocerca volvulus 0.0022 0.0043 0.0039
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0599 0.2014 1
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.09 1
Schistosoma mansoni tubulin subunit alpha 0.0273 0.09 0.6706
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0147 0.0469 0.0804
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0102 0.0754
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0004 0.0012
Echinococcus granulosus tubulin alpha 1C chain 0.0273 0.09 0.6706
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0301
Brugia malayi nuclear receptor NHR-88 0.0047 0.0127 0.0171
Schistosoma mansoni multidrug resistance protein 0.0011 0.0003 0.0018
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0125 0.1187
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0106 0.1167
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0011
Loa Loa (eye worm) ShTK domain-containing protein 0.0179 0.0578 0.5554
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0003 0.0018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0041 0.0149
Brugia malayi Tubulin alpha-2 chain 0.0273 0.09 0.1236
Leishmania major beta tubulin 0.0147 0.0469 0.173
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.09 0.1544
Trypanosoma brucei zeta tubulin 0.0064 0.0185 0.0681
Schistosoma mansoni nuclear receptor 0.0022 0.0043 0.0312
Plasmodium vivax multidrug resistance protein 1, putative 0.0011 0.0003 0.0009
Onchocerca volvulus 0.0083 0.0251 0.0248
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0043 0.0054
Trypanosoma brucei beta tubulin 0.0147 0.0469 0.173
Schistosoma mansoni hypothetical protein 0.0402 0.1341 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0004 0.0012
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0106 0.1167
Loa Loa (eye worm) ShTK domain-containing protein 0.0179 0.0578 0.5554
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0127 0.0941
Plasmodium falciparum tubulin epsilon chain, putative 0.0147 0.0469 0.173
Brugia malayi hypothetical protein 0.0039 0.0102 0.0136
Entamoeba histolytica tubulin gamma chain 0.0147 0.0469 0.521
Giardia lamblia Alpha-tubulin 0.0273 0.09 0.3323
Echinococcus granulosus tubulin alpha 1C chain 0.0273 0.09 0.6706
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.0127 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0463 0.0795
Echinococcus granulosus tubulin alpha chain 0.0273 0.09 0.6706
Echinococcus granulosus tubulin epsilon chain 0.0147 0.0469 0.3494
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.09 0.6706
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0111 0.0825
Plasmodium falciparum tubulin gamma chain 0.0147 0.0469 0.173
Plasmodium vivax tubulin alpha chain, putative 0.0273 0.09 0.3321
Echinococcus multilocularis hypothetical protein 0.0273 0.09 0.1544
Schistosoma mansoni transient receptor potential channel 0.0099 0.0305 0.2269
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0102 0.0174
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.0127 0.0124
Giardia lamblia Telomerase catalytic subunit 0.0802 0.2708 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.0127 0.1202
Trypanosoma brucei alpha tubulin 0.0273 0.09 0.3321
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0475
Brugia malayi hypothetical protein 0.0025 0.0052 0.0067
Giardia lamblia Alpha-tubulin 0.0273 0.09 0.3323
Trichomonas vaginalis ran, putative 0.0022 0.0041 0.0424
Loa Loa (eye worm) hypothetical protein 0.0047 0.0127 0.1202
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0043 0.0312
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.1052
Echinococcus granulosus tubulin gamma 1 chain 0.0147 0.0469 0.3494
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0043 0.0312
Echinococcus multilocularis geminin 0.0168 0.0541 0.0928
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0003 0.0018
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0179 0.0578 0.0792
Loa Loa (eye worm) hypothetical protein 0.0047 0.0127 0.1202
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0055 0.02
Echinococcus granulosus expressed conserved protein 0.0101 0.0313 0.2331
Schistosoma mansoni hypothetical protein 0.0107 0.0331 0.2465
Toxoplasma gondii beta-tubulin, putative 0.0147 0.0469 0.173
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0042 0.0111 0.0409
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0011 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0127 0.1202
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.0127 0.0217
Mycobacterium ulcerans oxidoreductase 0.0042 0.0111 0.0549
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0513 0.2734
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0469 0.0804
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0043 0.0312
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0113 0.0415
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.0127 0.0941
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.153
Leishmania major beta tubulin 0.0147 0.0469 0.173
Brugia malayi Tubulin alpha-2 chain 0.0273 0.09 0.1236
Plasmodium vivax importin-beta 2, putative 0.0029 0.0068 0.0247
Echinococcus granulosus cpg binding protein 0.003 0.0069 0.0511
Echinococcus granulosus tubulin alpha 3 chain 0.0273 0.09 0.6706
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.0127 0.0217
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0127 0.0217
Trichomonas vaginalis tubulin epsilon chain, putative 0.0147 0.0469 0.5197
Loa Loa (eye worm) alpha-tubulin 0.0273 0.09 0.8661
Loa Loa (eye worm) hypothetical protein 0.0062 0.0179 0.1709
Entamoeba histolytica tubulin alpha-1 chain 0.0273 0.09 1
Loa Loa (eye worm) tubulin beta chain 0.0147 0.0469 0.4505
Brugia malayi RNA, U transporter 1 0.0084 0.0253 0.0344
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0056 0.0073
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0209 0.0682 0.757
Echinococcus granulosus FTZ F1 alpha 0.0047 0.0127 0.0941
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0145 0.0533
Trypanosoma brucei beta tubulin 0.0147 0.0469 0.173
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0004 0.0025
Schistosoma mansoni hypothetical protein 0.0045 0.012 0.0887
Loa Loa (eye worm) RNA binding protein 0.007 0.0206 0.1964
Plasmodium vivax tubulin epsilon chain, putative 0.0147 0.0469 0.173
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.1004 0.3706
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0041 0.0069
Schistosoma mansoni cpg binding protein 0.003 0.0069 0.0511
Echinococcus multilocularis tubulin epsilon chain 0.0147 0.0469 0.0804
Echinococcus granulosus alpha tubulin 0.0273 0.09 0.6706
Brugia malayi CXXC zinc finger family protein 0.0028 0.0064 0.0084
Loa Loa (eye worm) hypothetical protein 0.0273 0.09 0.8661
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0049 0.0507
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0004 0.0017
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.09 1
Leishmania major beta tubulin 0.0147 0.0469 0.173
Loa Loa (eye worm) hypothetical protein 0.0108 0.0336 0.3217
Plasmodium falciparum tubulin beta chain 0.0147 0.0469 0.173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0301
Trypanosoma brucei alpha tubulin 0.0273 0.09 0.3321
Brugia malayi DKFZp564C0469 protein 0.0011 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0057 0.0161 0.153
Echinococcus multilocularis protoporphyrinogen oxidase 0.0042 0.0111 0.019
Leishmania major zeta tubulin, putative 0.0064 0.0185 0.0681
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0004 0.0015
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0469 0.3494
Schistosoma mansoni hypothetical protein 0.0045 0.012 0.0887
Brugia malayi nuclear receptor RXR 0.0025 0.0052 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0127 0.0171
Leishmania major beta tubulin 0.0147 0.0469 0.173
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0004 0.0011
Schistosoma mansoni tubulin subunit alpha 0.0273 0.09 0.6706
Brugia malayi tubulin alpha-2 chain 0.0273 0.09 0.1236
Mycobacterium ulcerans monoamine oxidase 0.0042 0.0111 0.0549
Echinococcus granulosus beta tubulin 0.0147 0.0469 0.3494
Echinococcus granulosus transient receptor potential gamma protein 0.0099 0.0305 0.2269
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0874
Loa Loa (eye worm) tubulin alpha chain 0.0273 0.09 0.8661
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0301
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0056 0.0204
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0111 0.0409
Echinococcus multilocularis tubulin subunit TubB 0.0273 0.09 0.1544
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0113 0.0415
Schistosoma mansoni topbp1 0.0011 0.0004 0.0025
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0004 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0052 0.0067
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0042 0.0111 0.0409
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0102 0.0754
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0043 0.0312
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.0127 0.0124
Loa Loa (eye worm) tubulin alpha-2 chain 0.0273 0.09 0.8661
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0043 0.0039
Schistosoma mansoni tubulin subunit beta 0.0147 0.0469 0.3494
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.0127 0.0941
Giardia lamblia Delta tubulin 0.0064 0.0185 0.0684
Trypanosoma brucei tubulin delta chain 0.0064 0.0185 0.0681
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0055 0.02
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0068 0.0247
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0127 0.0941
Trypanosoma cruzi tubulin delta chain 0.0064 0.0185 0.0681
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0043 0.0072
Giardia lamblia Beta tubulin 0.0147 0.0469 0.1733
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.0127 0.0171
Trichomonas vaginalis tubulin alpha chain, putative 0.0083 0.0251 0.2767
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Entamoeba histolytica P-glycoprotein-1 0.0011 0.0003 0.0026
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0336 0.0575
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.1052
Echinococcus multilocularis tubulin alpha chain 0.0273 0.09 0.1544
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0007
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.0149
Brugia malayi topoisomerase 0.0011 0.0004 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0056 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.0127 0.1202
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0004 0.0011
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0043 0.0054
Leishmania major epsilon tubulin, putative 0.0147 0.0469 0.173
Brugia malayi beta-tubulin, identical 0.0147 0.0469 0.0642
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0136 0.0183
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0125 0.0929
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0043 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0463 0.3451
Echinococcus granulosus nibrin 0.0011 0.0004 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0463 0.3451
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0206 0.1964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.0127 0.1202
Schistosoma mansoni hypothetical protein 0.0049 0.0136 0.1007
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.1052
Plasmodium vivax tubulin beta chain, putative 0.0147 0.0469 0.173
Schistosoma mansoni cpg binding protein 0.003 0.0069 0.0511
Schistosoma mansoni retinoic acid receptor RXR 0.0047 0.0127 0.0941
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0463 0.0634
Leishmania major beta tubulin 0.0147 0.0469 0.173
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0469 0.3494
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.0494 0.0847
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0191 0.1416
Schistosoma mansoni tubulin subunit beta 0.0147 0.0469 0.3494
Schistosoma mansoni importin beta-1 0.0029 0.0068 0.0498
Schistosoma mansoni DNA ligase IV 0.0011 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0179 0.0578 0.5554
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0011 0.0003 0.0009
Schistosoma mansoni hypothetical protein 0.0045 0.012 0.0887
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0179 0.0578 0.0792
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0469 0.0804
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0003 0.0004
Brugia malayi CHE-14 protein 0.0046 0.0125 0.0168
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0113 0.0415
Schistosoma mansoni transient receptor potential channel 0.0065 0.0191 0.1416
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0312 0.1033 0.5128
Trypanosoma brucei zeta tubulin, putative 0.0064 0.0185 0.0681
Echinococcus granulosus tubulin delta chain 0.0064 0.0185 0.1375
Trypanosoma brucei epsilon tubulin 0.0147 0.0469 0.173
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0599 0.2014 1
Entamoeba histolytica tubulin alpha chain, putative 0.0273 0.09 1
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.0127 0.0941
Loa Loa (eye worm) hypothetical protein 0.0179 0.0578 0.5554
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0458 0.1689
Giardia lamblia Beta tubulin 0.0147 0.0469 0.1733
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0043 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0056 0.0283
Echinococcus multilocularis peroxisome assembly protein 26 0.0273 0.09 0.1544
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.015 0.0551
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0475
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0518
Loa Loa (eye worm) hypothetical protein 0.0047 0.0127 0.1202
Loa Loa (eye worm) hypothetical protein 0.0049 0.0136 0.1287
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0064 0.0185 0.176
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0056 0.0274
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0301
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.09 0.1544
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0.0003 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.0127 0.1202
Brugia malayi ShTK domain containing protein 0.0179 0.0578 0.0792
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0127 0.0171
Plasmodium falciparum importin beta, putative 0.0029 0.0068 0.0247
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0043 0.0312
Trypanosoma cruzi epsilon tubulin, putative 0.0147 0.0469 0.173
Schistosoma mansoni hypothetical protein 0.0168 0.0541 0.4032
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0331 0.0452
Leishmania major beta tubulin 0.0147 0.0469 0.173
Brugia malayi hypothetical protein 0.0022 0.0043 0.0054
Onchocerca volvulus 0.0028 0.0064 0.0061
Entamoeba histolytica P-glycoprotein 5, putative 0.0011 0.0003 0.0026
Schistosoma mansoni tubulin subunit alpha 0.0064 0.0185 0.1375
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.0127 0.0941
Brugia malayi nuclear receptor NHR-88 0.0022 0.0043 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Echinococcus multilocularis tubulin alpha chain 0.0273 0.09 0.1544
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0312 0.1033 1
Brugia malayi Tubulin beta chain 0.0083 0.0251 0.0342
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0508
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.0127 0.0171
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0127 0.0217
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0802 0.2708 1
Schistosoma mansoni topbp1 0.0011 0.0004 0.0025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.0127 0.0941
Leishmania major p-glycoprotein 0.0011 0.0003 0.0009
Schistosoma mansoni tubulin subunit epsilon 0.0147 0.0469 0.3494
Loa Loa (eye worm) tubulin alpha 2 0.0209 0.0682 0.6558
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0185 0.203
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0341 0.2541
Trichomonas vaginalis tubulin epsilon chain, putative 0.0273 0.09 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0111 0.0409
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Loa Loa (eye worm) hypothetical protein 0.0029 0.0068 0.063
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.1052
Echinococcus granulosus tubulin beta 4A class IVa 0.0147 0.0469 0.3494
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0017
Schistosoma mansoni amine oxidase 0.0042 0.0111 0.0825
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0052 0.0067
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0004 0.0011
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0052 0.0475
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0064 0.0185 0.203
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0003 0.0004
Schistosoma mansoni tubulin subunit gamma 0.0147 0.0469 0.3494
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0111 0.0825
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0004 0.0012
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.0152
Brugia malayi tubulin alpha chain - mouse 0.0273 0.09 0.1236
Trichomonas vaginalis tubulin alpha chain, putative 0.0083 0.0251 0.2767
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.0127 0.0171
Echinococcus multilocularis 0.0042 0.0111 0.019
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0052 0.0087
Trypanosoma cruzi zeta tubulin, putative 0.0064 0.0185 0.0681
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0011 0.0003 0.0009
Loa Loa (eye worm) beta-tubulin 0.0147 0.0469 0.4505
Schistosoma mansoni transient receptor potential channel 4 0.0099 0.0305 0.2269
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0185 0.203
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0055 0.02
Brugia malayi steroid hormone receptor 0.0047 0.0127 0.0171
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0475
Brugia malayi RNA binding protein 0.007 0.0206 0.0279
Leishmania major importin beta-1 subunit, putative 0.0024 0.0049 0.0177
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0475
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0136 0.1007
Plasmodium falciparum protoporphyrinogen oxidase 0.0042 0.0111 0.0409
Leishmania major UDP-galactopyranose mutase 0.0042 0.0111 0.0409
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0034 0.0295
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.0127 0.0941
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0042 0.0111 0.0825
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0042 0.0111 0.019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0017
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.153
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.0127 0.0124
Plasmodium falciparum tubulin delta chain, putative 0.0064 0.0185 0.0681
Entamoeba histolytica P-glycoprotein-5 0.0011 0.0003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0125 0.0214
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0518
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0136 0.0232
Echinococcus granulosus tubulin subunit TubB 0.0273 0.09 0.6706
Mycobacterium ulcerans hypothetical protein 0.0026 0.0056 0.0274
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0049 0.0507
Trichomonas vaginalis tubulin gamma chain, putative 0.0147 0.0469 0.5197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0052 0.0379
Leishmania major beta tubulin 0.0147 0.0469 0.173
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0043 0.0072
Leishmania major beta tubulin 0.0147 0.0469 0.173
Brugia malayi hypothetical protein 0.0022 0.0043 0.0054
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0043 0.0388
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.153
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0056 0.0274
Echinococcus granulosus snurportin 1 0.0314 0.1038 0.774
Trichomonas vaginalis tubulin, putative 0.0147 0.0469 0.5197
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0007 0.0043
Echinococcus granulosus tubulin beta 1 chain 0.0147 0.0469 0.3494
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0004 0.0012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0007 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0056 0.0274
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0004 0.0001
Brugia malayi Cell division protein ftsZ 0.0064 0.0185 0.0251
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0034 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0004 0.0012
Leishmania major delta tubulin, putative 0.0064 0.0185 0.0681
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0052 0.0379
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0463 0.3451
Echinococcus granulosus importin subunit beta 1 0.0029 0.0068 0.0498
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.1052
Onchocerca volvulus 0.0179 0.0578 0.0575
Plasmodium vivax telomerase reverse transcriptase, putative 0.0802 0.2708 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0147 0.0469 0.4505
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0043 0.0072
Brugia malayi conserved hypotetical protein 0.0022 0.0043 0.0054
Plasmodium vivax delta tubulin, putative 0.0064 0.0185 0.0681
Loa Loa (eye worm) tubulin alpha 2 0.0209 0.0682 0.6558
Trichomonas vaginalis tubulin beta chain, putative 0.0083 0.0251 0.2767
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.0127 0.1202
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Echinococcus granulosus geminin 0.0168 0.0541 0.4032
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0043 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0043 0.0072
Trichomonas vaginalis tubulin gamma chain, putative 0.0064 0.0185 0.203
Loa Loa (eye worm) BEN-1 protein 0.0147 0.0469 0.4505
Schistosoma mansoni multidrug resistance protein 0.0011 0.0003 0.0018
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0469 0.0804
Schistosoma mansoni tubulin subunit beta 0.0147 0.0469 0.3494
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0469 0.3494
Leishmania major beta tubulin 0.0147 0.0469 0.173
Mycobacterium ulcerans cell division protein FtsZ 0.0064 0.0185 0.0916
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0052 0.0379
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0043 0.0388
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0017
Brugia malayi Importin beta-1 subunit 0.0029 0.0068 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0127 0.0171
Leishmania major telomerase reverse transcriptase, putative 0.0802 0.2708 1
Schistosoma mansoni tubulin subunit beta 0.0147 0.0469 0.3494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0043 0.0312
Trypanosoma cruzi tubulin delta chain 0.0064 0.0185 0.0681
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0206 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.0127 0.0171
Schistosoma mansoni multidrug resistance protein 0.0011 0.0003 0.0018
Brugia malayi Tubulin beta-1 chain 0.0147 0.0469 0.0642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.003 0.0144
Loa Loa (eye worm) alpha-tubulin 0.0273 0.09 0.8661
Echinococcus multilocularis protein patched 0.0046 0.0125 0.0214
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0136 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0011
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.0111 0.058
Trichomonas vaginalis tubulin epsilon chain, putative 0.0147 0.0469 0.5197
Loa Loa (eye worm) BEN-1 protein 0.0147 0.0469 0.4505
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0136 0.0232
Echinococcus granulosus tubulin alpha 3 chain 0.0273 0.09 0.6706
Loa Loa (eye worm) DR-78 0.0022 0.0043 0.0388
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Toxoplasma gondii RNA-directed DNA polymerase 0.0802 0.2708 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0172 0.1277
Echinococcus multilocularis transient receptor potential ion channel A 0.0096 0.0294 0.0503
Brugia malayi Tubulin alpha chain 0.0064 0.0185 0.0251
Entamoeba histolytica Ran family GTPase 0.0022 0.0041 0.0449
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Brugia malayi Tubulin alpha chain 0.0273 0.09 0.1236
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0127 0.0171
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.1004 0.3706
Brugia malayi nuclear hormone receptor 0.0022 0.0043 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.05 0.48
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.0127 0.1202
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0055 0.02
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0003 0.0018
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0041 0.0149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.0127 0.0941
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.0185 0.0681
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0056 0.0274
Toxoplasma gondii beta tubulin 0.0147 0.0469 0.173
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0312 0.1033 1
Schistosoma mansoni cpg binding protein 0.0028 0.0064 0.047
Echinococcus multilocularis transient receptor potential gamma protein 0.0099 0.0305 0.0523
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0125 0.0929
Schistosoma mansoni tubulin subunit beta 0.0147 0.0469 0.3494
Trichomonas vaginalis tubulin alpha chain, putative 0.0147 0.0469 0.5197
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0004 0.0012
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.09 0.1544
Loa Loa (eye worm) hypothetical protein 0.0107 0.0331 0.3174
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0136 0.1007
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0083 0.0251 0.2767
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.1125
Echinococcus multilocularis tubulin beta 1 chain 0.0147 0.0469 0.0804
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0127 0.0941
Leishmania major beta tubulin 0.0147 0.0469 0.173
Schistosoma mansoni alpha tubulin 0.0273 0.09 0.6706
Echinococcus multilocularis GPCR, family 2 0.0049 0.0136 0.0232
Echinococcus granulosus tubulin subunit beta 0.0147 0.0469 0.3494
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.0494 0.3677
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0056 0.0274
Brugia malayi SWIRM domain containing protein 0.0042 0.0111 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0301
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0111 0.0409
Entamoeba histolytica P-glyco protein 6, putative 0.0011 0.0003 0.0026
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.09 1
Echinococcus granulosus transient receptor potential ion channel A 0.0096 0.0294 0.2185
Trypanosoma cruzi tubulin gamma chain 0.0147 0.0469 0.173
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0056 0.0614
Loa Loa (eye worm) tubulin beta-2A chain 0.0147 0.0469 0.4505
Schistosoma mansoni tubulin subunit beta 0.0064 0.0185 0.1375
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0042 0.0111 0.0825
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0003 0.0026
Brugia malayi hypothetical protein 0.0011 0.0004 0.0001
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.1125
Loa Loa (eye worm) tubulin alpha 2 0.0126 0.0398 0.3817
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0049 0.0177
Trypanosoma brucei beta tubulin 0.0147 0.0469 0.173
Brugia malayi Telomerase reverse transcriptase 0.2135 0.726 1
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0106 0.1167
Brugia malayi hypothetical protein 0.0025 0.0052 0.0067
Trichomonas vaginalis tubulin alpha chain, putative 0.0083 0.0251 0.2767
Giardia lamblia Epsilon tubulin 0.0064 0.0185 0.0684
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1715 0.5823 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0056 0.0274
Trichomonas vaginalis tubulin gamma chain, putative 0.0147 0.0469 0.5197
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0388
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0043 0.0054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.0127 0.0217
Toxoplasma gondii beta-1 tubulin, putative 0.0147 0.0469 0.173
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0034 0.0163
Schistosoma mansoni zinc finger protein 0.0022 0.0043 0.0312
Loa Loa (eye worm) hypothetical protein 0.0047 0.0127 0.1202
Brugia malayi hypothetical protein 0.0042 0.0111 0.0149
Trypanosoma cruzi epsilon tubulin, putative 0.0147 0.0469 0.173
Mycobacterium ulcerans hypothetical protein 0.016 0.0513 0.2546
Mycobacterium leprae cell division protein FtsZ 0.0064 0.0185 1
Schistosoma mansoni tyrosinase precursor 0.0179 0.0578 0.4304
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0011
Trichomonas vaginalis tubulin alpha chain, putative 0.0147 0.0469 0.5197
Schistosoma mansoni hypothetical protein 0.0168 0.0541 0.4032
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0056 0.0614
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.1038 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0034 0.0121
Schistosoma mansoni nuclear receptor 0.0022 0.0043 0.0312
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0049 0.0507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.003 0.0144
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0041 0.0149
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0042 0.0111 0.5925
Onchocerca volvulus 0.0179 0.0578 0.0575
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0312 0.1033 0.5128
Brugia malayi amine oxidase, flavin-containing family protein 0.0042 0.0111 0.0149
Echinococcus multilocularis tubulin delta chain 0.0064 0.0185 0.0317
Trypanosoma brucei beta tubulin 0.0147 0.0469 0.173
Chlamydia trachomatis protoporphyrinogen oxidase 0.0042 0.0111 0.1051
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.019 0.0616 0.6833
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0127 0.0171
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0055 0.02
Trypanosoma brucei epsilon tubulin 0.0147 0.0469 0.173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0463 0.3451
Brugia malayi hypothetical protein 0.0026 0.0055 0.0071
Brugia malayi Tubulin beta chain 0.0064 0.0185 0.0251
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0056 0.0204
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0003 0.0026
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0336 0.3725
Mycobacterium tuberculosis Cell division protein FtsZ 0.0064 0.0185 0.0975
Echinococcus multilocularis tubulin alpha chain 0.0273 0.09 0.1544
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0106 0.1167
Trypanosoma brucei alpha tubulin, putative 0.0083 0.0251 0.0925
Leishmania major beta tubulin 0.0147 0.0469 0.173
Toxoplasma gondii alpha tubulin TUBA1 0.0273 0.09 0.3321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0463 0.3451
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0.0003 0.0007
Echinococcus multilocularis tubulin alpha 3 chain 0.0273 0.09 0.1544
Echinococcus granulosus tubulin alpha chain 0.0273 0.09 0.6706
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0004 0.0011
Plasmodium vivax tubulin alpha chain, putative 0.0273 0.09 0.3321
Leishmania major GTP-binding protein, putative 0.0022 0.0041 0.0149
Trypanosoma brucei alpha tubulin 0.0273 0.09 0.3321
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0034 0.0121
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Loa Loa (eye worm) tubulin alpha chain 0.0273 0.09 0.8661
Entamoeba histolytica tubulin family protein 0.0147 0.0469 0.521
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0043 0.0312
Trypanosoma brucei beta tubulin 0.0147 0.0469 0.173
Trypanosoma brucei tubulin gamma chain 0.0147 0.0469 0.173
Leishmania major hypothetical protein, conserved 0.0026 0.0055 0.02
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0458 0.1689
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0463 0.0795
Schistosoma mansoni smdr2 0.0011 0.0003 0.0018
Echinococcus granulosus GPCR family 2 0.0049 0.0136 0.1007
Schistosoma mansoni ran 0.0022 0.0041 0.0301
Onchocerca volvulus 0.0047 0.0127 0.0124
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0469 0.0804
Schistosoma mansoni hypothetical protein 0.0012 0.0007 0.0043
Onchocerca volvulus 0.0179 0.0578 0.0575
Loa Loa (eye worm) tyrosinase 1 0.0179 0.0578 0.5554
Schistosoma mansoni amine oxidase 0.0042 0.0111 0.0825
Leishmania major alpha tubulin 0.0273 0.09 0.3321
Echinococcus granulosus dnaJ subfamily B 0.0402 0.1341 1
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0106 0.1167
Echinococcus granulosus tubulin alpha chain 0.0273 0.09 0.6706
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.0127 0.0941
Entamoeba histolytica hypothetical protein 0.0024 0.0049 0.0532

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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