Detailed information for compound 170270

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 398.717 | Formula: C17H18Cl3N5--
  • H donors: 2 H acceptors: 1 LogP: 4.07 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C1CC(=NN=C(N)N)c2c(C1)nccc2C.[Cl-].[Cl-]
  • InChi: 1S/C17H18ClN5.2ClH/c1-10-5-6-21-14-8-12(11-3-2-4-13(18)7-11)9-15(16(10)14)22-23-17(19)20;;/h2-7,12H,8-9H2,1H3,(H4,19,20,23);2*1H/p-2/b22-15+;;
  • InChiKey: MAUOBGCJCPUQQL-IFGMWRHRSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Plasmodium falciparum DNA topoisomerase 2 0.0456 0.2109 0.2103
Giardia lamblia Sodium/hydrogen exchanger 3 0.01 0.0408 0.1729
Schistosoma mansoni pyruvate dehydrogenase 0.0032 0.0084 0.0225
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0019 0.0023 0.0023
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0084 0.0223
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0008 0.0021
Onchocerca volvulus 0.0027 0.0061 0.0163
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0309 0.0819
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0072 0.0279 0.0743
Plasmodium vivax endoplasmin, putative 0.0032 0.0084 0.0077
Entamoeba histolytica DNA topoisomerase II, putative 0.0456 0.2109 1
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.0408 0.1089
Brugia malayi beta-lactamase family protein 0.0035 0.01 0.0475
Trichomonas vaginalis glutaminase, putative 0.0266 0.1202 0.4942
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0397 0.1884
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0032 0.0084 0.0084
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0084 0.0223
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0934 0.4391 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0028 0.0133
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0021 0.0032 0.0085
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0008 0.0018
Giardia lamblia DNA topoisomerase II 0.0424 0.1957 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.01 0.0475
Loa Loa (eye worm) NHE-3 0.01 0.0408 0.1936
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Mycobacterium leprae Probable two-component sensor kinase 0.0032 0.0084 0.0178
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0108 0.0127
Leishmania major oxidoreductase-like protein 0.0021 0.0032 0.0085
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0182 0.0485
Loa Loa (eye worm) endoplasmin 0.0032 0.0084 0.04
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.01 0.0475
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0061 0.029
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.01 0.0069
Loa Loa (eye worm) hypothetical protein 0.0165 0.072 0.3414
Trypanosoma brucei oxidoreductase-like protein 0.0021 0.0032 0.0085
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0084 0.0223
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.007 0.0268 0.0709
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0032 0.0084 0.0084
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.0268 0.0268
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0023 0.0061
Schistosoma mansoni inositol monophosphatase 0.0079 0.0309 0.0824
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0072 0.0279 0.0738
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0023 0.0053
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Leishmania major Na/H antiporter-like protein 0.0019 0.0023 0.0061
Trypanosoma cruzi ISWI complex protein 0.0015 0.0003 0.0009
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0042 0.0042
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0084 0.0223
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.0408 0.1657
Trypanosoma brucei DNA topoisomerase IA, putative 0.0072 0.0279 0.0738
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0397 0.0905
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Schistosoma mansoni hypothetical protein 0.002 0.0028 0.0075
Echinococcus granulosus GPCR family 2 0.0052 0.0182 0.0485
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0023 0.0062
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0653
Loa Loa (eye worm) hypothetical protein 0.0219 0.0978 0.4636
Loa Loa (eye worm) hypothetical protein 0.01 0.0408 0.1936
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0805 0.3776 1
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.055 0.1466
Trypanosoma cruzi ISWI complex protein 0.0015 0.0003 0.0009
Echinococcus granulosus heat shock protein 0.0032 0.0084 0.0225
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0084 0.0084
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Mycobacterium ulcerans beta-lactamase 0.0035 0.01 0.01
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.01 0.0475
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.0318 0.0847
Leishmania major DNA topoisomerase ii 0.0383 0.1763 0.4669
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0309 0.0824
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0182 0.0861
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0008 0.0021
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Loa Loa (eye worm) hypothetical protein 0.004 0.0121 0.0574
Schistosoma mansoni heat shock protein 0.0032 0.0084 0.0225
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0084 0.0293
Onchocerca volvulus 0.0035 0.01 0.0331
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0032 0.0084 0.0084
Echinococcus multilocularis heat shock protein 90 0.0032 0.0084 0.0192
Trypanosoma cruzi DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Loa Loa (eye worm) hypothetical protein 0.0219 0.0978 0.4636
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0072 0.0279 0.0859
Toxoplasma gondii Na+/H+ exchanger NHE1 0.0019 0.0023 0.0023
Brugia malayi Cytochrome P450 family protein 0.0023 0.0042 0.0198
Loa Loa (eye worm) hypothetical protein 0.01 0.0408 0.1936
Trypanosoma brucei DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0309 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.01 0.0265
Schistosoma mansoni bromodomain containing protein 0.0063 0.0233 0.0622
Brugia malayi beta-lactamase 0.0035 0.01 0.0475
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0108 0.0513
Schistosoma mansoni lamin 0.0027 0.0061 0.0163
Schistosoma mansoni zinc finger protein 0.0021 0.0031 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.0471 0.2232
Echinococcus granulosus zinc finger protein 0.0021 0.0031 0.0083
Leishmania major hypothetical protein, conserved 0.0019 0.0023 0.0061
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0032 0.0084 0.0061
Loa Loa (eye worm) inositol-1 0.0079 0.0309 0.1465
Schistosoma mansoni hypothetical protein 0.0052 0.0182 0.0485
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.01 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0084 0.0077
Trypanosoma cruzi DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0108 0.0287
Mycobacterium ulcerans lipase LipD 0.0035 0.01 0.01
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0084 0.0223
Loa Loa (eye worm) sodium/hydrogen exchanger 0.01 0.0408 0.1936
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0032 0.0084 0.0061
Plasmodium vivax DNA gyrase subunit A, putative 0.2109 1 1
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.0408 0.1089
Giardia lamblia DNA topoisomerase III 0.0072 0.0279 0.1037
Brugia malayi Bromodomain containing protein 0.0074 0.0288 0.1364
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Brugia malayi Calcitonin receptor-like protein seb-1 0.0165 0.072 0.3414
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0084 0.0223
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0032 0.0084 0.0084
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0108 0.0407
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.029
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0011 0.0031
Leishmania major mitochondrial DNA topoisomerase II 0.0805 0.3776 1
Brugia malayi hypothetical protein 0.0019 0.0023 0.011
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0001 0.0007
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.027 0.057
Giardia lamblia DNA topoisomerase III 0.0072 0.0279 0.1037
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0009
Loa Loa (eye worm) DNA topoisomerase III 0.0072 0.0279 0.1321
Onchocerca volvulus 0.0064 0.0239 0.093
Toxoplasma gondii DNA topoisomerase family protein 0.0072 0.0279 0.0279
Echinococcus multilocularis musashi 0.0027 0.0061 0.0139
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.2109 1 1
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0042 0.0111
Mycobacterium ulcerans ion antiporter, NhaP 0.0019 0.0023 0.0023
Mycobacterium ulcerans two component sensor kinase MprB 0.0032 0.0084 0.0084
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0021 0.0032 0.0032
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1014 0.4775 0.4775
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0072 0.0279 0.0279
Toxoplasma gondii Na+/H+ exchanger NHE3 0.0019 0.0023 0.0023
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0032 0.0084 0.0084
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0072 0.0279 0.0743
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0042 0.0111
Mycobacterium ulcerans putative regultory protein 0.0032 0.0084 0.0084
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0075 0.0289 0.1368
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0186 0.0822 0.0814
Brugia malayi Cytochrome P450 family protein 0.0023 0.0042 0.0198
Echinococcus multilocularis rho GTPase activating protein 20 0.0072 0.0279 0.0635
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0032 0.0084 0.0192
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.1245 0.5876 0.5873
Brugia malayi isocitrate dehydrogenase 0.0016 0.0008 0.0037
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0045 0.0102
Plasmodium vivax DNA topoisomerase II, putative 0.0456 0.2109 0.2103
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0182 0.0414
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0008 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0035 0.01 0.0092
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0084 0.0084
Schistosoma mansoni ap endonuclease 0.0037 0.0108 0.0289
Schistosoma mansoni heat shock protein 0.0032 0.0084 0.0225
Schistosoma mansoni glutaminase 0.0266 0.1202 0.3207
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.0408 0.1089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0318 0.0849
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0018
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0045 0.0119
Onchocerca volvulus 0.0029 0.0069 0.0199
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0032 0.0084 0.0084
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.1245 0.5876 0.5873
Schistosoma mansoni endoplasmin 0.0032 0.0084 0.0225
Schistosoma mansoni hypothetical protein 0.0113 0.0471 0.1256
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0011 0.0026
Schistosoma mansoni lamin 0.0027 0.0061 0.0163
Mycobacterium ulcerans membrane transporter 0.0019 0.0023 0.0023
Loa Loa (eye worm) TOPoisomerase family member 0.0456 0.2109 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0008 0.0021
Brugia malayi Bromodomain containing protein 0.0037 0.011 0.0521
Trichomonas vaginalis esterase, putative 0.0035 0.01 0.0069
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0182 0.0861
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0182 0.0863
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.01 0.01
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0309 0.0819
Mycobacterium ulcerans DNA gyrase subunit A 0.2109 1 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0031 0.007
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0032 0.0084 0.0192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0397 0.0905
Brugia malayi GRF zinc finger family protein 0.0072 0.0279 0.1321
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.0408 0.1657
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0072 0.0279 0.1321
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0456 0.2109 0.8979
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Onchocerca volvulus 0.0506 0.2347 1
Plasmodium falciparum DNA gyrase subunit B 0.1014 0.4775 0.477
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0214 0.0214
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0108 0.0085
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0008 0.0018
Trypanosoma cruzi DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Brugia malayi beta-lactamase family protein 0.0035 0.01 0.0475
Echinococcus multilocularis GPCR, family 2 0.0052 0.0182 0.0414
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0032 0.0084 0.0223
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.01 0.0069
Brugia malayi glutaminase DH11.1 0.0266 0.1202 0.57
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.055 0.055
Echinococcus granulosus microtubule associated protein 2 0.0799 0.3749 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0052 0.0182 0.0485
Schistosoma mansoni zinc finger protein 0.0015 0.0003 0.0009
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0032 0.0084 0.0225
Schistosoma mansoni ap endonuclease 0.0037 0.0108 0.0289
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0186 0.0822 0.08
Brugia malayi PHD-finger family protein 0.0026 0.0056 0.0264
Mycobacterium leprae Probable two component sensor kinase MprB 0.0032 0.0084 0.0178
Plasmodium falciparum heat shock protein 90 0.0032 0.0084 0.0077
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.0408 0.093
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0072 0.0279 0.0859
Schistosoma mansoni hypothetical protein 0.0019 0.0023 0.0062
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.01 0.01
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.0019 0.0023 0.0062
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.01 0.0069
Toxoplasma gondii exonuclease III APE 0.0037 0.0108 0.0108
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.0032 0.0032
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.01 0.01
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0164 0.0718 0.3403
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0586 0.2731 0.2731
Mycobacterium tuberculosis Possible two component sensor kinase 0.0032 0.0084 0.0084
Mycobacterium ulcerans glutaminase 0.0266 0.1202 0.1202
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0456 0.2109 0.8979
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1245 0.5876 0.5876
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0019 0.0023 0.011
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.01 0.0408 0.1936
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0084 0.0223
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0007
Echinococcus granulosus lamin dm0 0.0027 0.0061 0.0163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0084 0.04
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0217 0.0494
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0072 0.0279 0.0635
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0225 0.06
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.01 0.0228
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.01 0.01
Onchocerca volvulus 0.0021 0.0032 0.0038
Brugia malayi CXXC zinc finger family protein 0.0029 0.0069 0.0329
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0239 0.0239
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0032 0.0084 0.0077
Schistosoma mansoni cpg binding protein 0.0032 0.0086 0.023
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0061 0.029
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.0408 0.093
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.2109 1 1
Onchocerca volvulus 0.0035 0.01 0.0331
Loa Loa (eye worm) hypothetical protein 0.01 0.0408 0.1936
Leishmania major DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Mycobacterium tuberculosis Conserved protein 0.0035 0.01 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0397 0.106
Trypanosoma brucei ISWI complex protein 0.0015 0.0003 0.0009
Plasmodium vivax DNA gyrase subunit B, putative 0.1014 0.4775 0.477
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0032 0.0084 0.0084
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.0032 0.0032
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0.0032 0.0032
Toxoplasma gondii ABC1 family protein 0.0035 0.01 0.01
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0032 0.0084 0.0084
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0008 0.0008
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0072 0.0279 0.0738
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0309 0.0704
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0165 0.072 0.3414
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.0318 0.0723
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0072 0.0279 0.0743
Plasmodium falciparum DNA topoisomerase 3, putative 0.0072 0.0279 0.0271
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.055 0.1455
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.01 0.0265
Plasmodium falciparum endoplasmin, putative 0.0032 0.0084 0.0077
Mycobacterium leprae Probable lipase LipE 0.0035 0.01 0.0212
Schistosoma mansoni inositol monophosphatase 0.0079 0.0309 0.0824
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.007 0.0268 0.1269
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0023 0.0061
Mycobacterium ulcerans DNA gyrase subunit B 0.1014 0.4775 0.4775
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0309 0.137
Entamoeba histolytica DNA topoisomerase III, putative 0.0072 0.0279 0.1224
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0186 0.0822 0.0822
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0397 0.1884
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0108 0.0287
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0014 0.0068
Echinococcus multilocularis lamin dm0 0.0027 0.0061 0.0139
Mycobacterium ulcerans hypothetical protein 0.0035 0.01 0.01
Leishmania major hypothetical protein, conserved 0.0035 0.01 0.0265
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0042 0.0198
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0186 0.0822 0.0822
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0309 0.0993
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.2109 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0239 0.0638
Treponema pallidum DNA topoisomerase I (topA) 0.0072 0.0279 0.0196
Brugia malayi Probable DNA topoisomerase II 0.0456 0.2109 1
Leishmania major DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0309 0.0309
Loa Loa (eye worm) glutaminase 0.0266 0.1202 0.57
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0108 0.01
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0318 0.0849
Onchocerca volvulus 0.0072 0.0279 0.1099
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1245 0.5876 0.5876
Leishmania major hypothetical protein, conserved 0.0015 0.0003 0.0009
Trypanosoma brucei developmentally regulated phosphoprotein 0.0032 0.0084 0.0223
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0021
Mycobacterium tuberculosis Conserved protein 0.0035 0.01 0.01
Trichomonas vaginalis DNA topoisomerase II, putative 0.0456 0.2109 0.8952
Plasmodium falciparum enoyl-acyl carrier reductase 0.0186 0.0822 0.0814
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0456 0.2109 1
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.0408 0.1657
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.055 0.055
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Brugia malayi heat shock protein 90 0.0032 0.0084 0.04
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0108 0.0289
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0032 0.0084 0.0178
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0032 0.0084 0.0084
Entamoeba histolytica DNA topoisomerase III, putative 0.0072 0.0279 0.1224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0397 0.106
Plasmodium falciparum sodium/hydrogen exchanger, Na+, H+ antiporter 0.0019 0.0023 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0182 0.0861
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0456 0.2109 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0021
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.0268 0.061
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.0268 0.0714
Loa Loa (eye worm) hypothetical protein 0.0164 0.0716 0.3395
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.055 0.055
Brugia malayi Sodium/hydrogen exchanger 8 0.0019 0.0023 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.01 0.0265
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.055 0.1466
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0018
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0309 0.0309
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0108 0.0105
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0032 0.0084 0.0084
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.01 0.0408 0.1936
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.1014 0.4775 0.473
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0023 0.0061
Echinococcus granulosus geminin 0.0186 0.0821 0.2191
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.0019 0.0023 0.0053
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.0408 0.093
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0805 0.3776 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0309 0.0993
Brugia malayi Pre-SET motif family protein 0.0444 0.2054 0.9737
Toxoplasma gondii sodium/hydrogen exchanger NHE2 0.0019 0.0023 0.0023
Toxoplasma gondii DNA topoisomerase 2, putative 0.0456 0.2109 0.2109
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.0408 0.093
Loa Loa (eye worm) hypothetical protein 0.0113 0.0471 0.2232
Leishmania major pteridine reductase 1 0.0021 0.0032 0.0085
Brugia malayi kinase, mitochondrial precursor 0.0032 0.0084 0.04
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0084 0.0223
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.0268 0.0268
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.0268 0.0268
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.1245 0.5876 0.5867
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.1014 0.4775 0.4762
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.055 0.1466
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0099 0.0264
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0234 0.0625
Schistosoma mansoni hypothetical protein 0.0186 0.0821 0.2191
Brugia malayi intermediate filament protein 0.0027 0.0061 0.029
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0456 0.2109 0.4804
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.2109 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0023 0.0062
Trypanosoma brucei DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0072 0.0279 0.0256
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0309 0.0993
Echinococcus granulosus muscleblind protein 0.0164 0.0716 0.191
Schistosoma mansoni microtubule-associated protein tau 0.0799 0.3749 1
Brugia malayi Endoplasmin precursor 0.0032 0.0084 0.04
Leishmania major DNA topoisomerase 1A 0.0072 0.0279 0.0738
Loa Loa (eye worm) hypothetical protein 0.0081 0.0318 0.1509
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0182 0.0414
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0032 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0164 0.0716 0.3395
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0023 0.0061
Loa Loa (eye worm) hypothetical protein 0.0164 0.0718 0.3403
Leishmania major cytochrome p450-like protein 0.0023 0.0042 0.0111
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0032 0.0084 0.0178
Trypanosoma cruzi DNA topoisomerase II, putative 0.0383 0.1763 0.4669
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.055 0.055
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0032 0.0084 0.0084
Schistosoma mansoni cpg binding protein 0.0029 0.0069 0.0185
Chlamydia trachomatis oxoacyl-ACP synthase III 0.1245 0.5876 0.5841
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.1245 0.5876 0.5876
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.01 0.0408 0.1089
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0349 0.16 0.3381
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0084 0.04
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.1245 0.5876 0.5876
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0032 0.0084 0.0084
Brugia malayi DNA topoisomerase III beta-1 0.0072 0.0279 0.1321
Schistosoma mansoni endoplasmin 0.0032 0.0084 0.0225
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0318 0.0725
Mycobacterium tuberculosis Probable two component sensor kinase 0.0032 0.0084 0.0084
Chlamydia trachomatis DNA topoisomerase I 0.0072 0.0279 0.0196
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.0408 0.1089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0397 0.106
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.055 0.055
Echinococcus multilocularis muscleblind protein 1 0.0164 0.0716 0.1631
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0069 0.0329
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0108 0.0108
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0042 0.0198
Chlamydia trachomatis DNA gyrase subunit A 0.0219 0.0978 0.0901
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.01 0.01
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.1005 0.4732 1
Echinococcus multilocularis geminin 0.0186 0.0821 0.1871
Chlamydia trachomatis DNA gyrase subunit B 0.0665 0.3107 0.3049
Toxoplasma gondii sodium/hydrogen exchanger 3 protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0008 0.0037
Echinococcus granulosus lamin 0.0027 0.0061 0.0163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0318 0.0849
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0084 0.0223
Echinococcus multilocularis heat shock protein 0.0032 0.0084 0.0192
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.01 0.01
Brugia malayi Inositol-1 0.0079 0.0309 0.1465
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0084 0.0084
Brugia malayi Pre-SET motif family protein 0.0064 0.0239 0.1135
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0383 0.1763 0.4669
Plasmodium vivax sodium/hydrogen exchanger 1, putative 0.0019 0.0023 0.0015
Mycobacterium ulcerans DNA topoisomerase I 0.0072 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0522
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Echinococcus granulosus heat shock protein 90 0.0032 0.0084 0.0225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.011
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0072 0.0279 0.0743
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Echinococcus multilocularis cpg binding protein 0.0032 0.0086 0.0196
Loa Loa (eye worm) hypothetical protein 0.0069 0.026 0.1233
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Trypanosoma brucei DNA topoisomerase ii 0.0805 0.3776 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0186 0.0822 0.1737
Loa Loa (eye worm) glutaminase 2 0.0266 0.1202 0.57
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0108 0.0513
Echinococcus multilocularis muscleblind protein 0.0164 0.0716 0.1631
Mycobacterium tuberculosis Conserved protein 0.0035 0.01 0.01
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0021 0.0032 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0397 0.106
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0108 0.0287
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.007 0.0268 0.0714
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0108 0.0247
Mycobacterium tuberculosis Probable conserved integral membrane transport protein YjcE 0.0019 0.0023 0.0023
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0032 0.0084 0.0084
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0108 0.0287
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0108 0.0024
Onchocerca volvulus 0.0035 0.01 0.0331
Schistosoma mansoni DNA topoisomerase II 0.0456 0.2109 0.5626
Mycobacterium leprae conserved hypothetical protein 0.0035 0.01 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0397 0.106
Brugia malayi Muscleblind-like protein 0.0164 0.0716 0.3395
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0279
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0084 0.0223
Echinococcus granulosus dnaJ subfamily B 0.0409 0.1883 0.5023
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0309 0.0819
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0186 0.0822 0.0744
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0061 0.029
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.027 0.027
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.01 0.0267
Plasmodium falciparum DNA gyrase subunit A 0.2109 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0165 0.072 0.3414
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0032 0.0084 0.0084
Trichomonas vaginalis hypothetical protein 0.0186 0.0822 0.3259
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0045 0.0119
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0186 0.0822 0.0822
Chlamydia trachomatis DNA gyrase subunit B 0.1014 0.4775 0.473
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0072 0.0279 0.0589
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0182 0.0485
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0032 0.0084 0.0084
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1003 0.1003
Schistosoma mansoni intermediate filament proteins 0.0027 0.0061 0.0163
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.0032 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0444 0.2054 0.9737
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0032 0.0084 0.0084
Echinococcus granulosus sodium:hydrogen exchanger 7 0.0019 0.0023 0.0062
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0032 0.0084 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0239 0.0638
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.0408 0.1089
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Schistosoma mansoni hypothetical protein 0.0052 0.0182 0.0485
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0108 0.0105
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Mycobacterium tuberculosis Conserved protein 0.0032 0.0084 0.0084
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0008 0.0008
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0084 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.01 0.0267
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0084 0.0223
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.0408 0.093
Schistosoma mansoni hypothetical protein 0.0186 0.0821 0.2191
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0309 0.0819
Trichomonas vaginalis set domain proteins, putative 0.0506 0.2347 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0383 0.1763 0.4669
Schistosoma mansoni sodium/hydrogen exchanger 0.01 0.0408 0.1089
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.01 0.01
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.1883 0.429
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.01 0.0267
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.01 0.01
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0108 0.0108
Echinococcus granulosus intermediate filament protein 0.0027 0.0061 0.0163
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0217 0.0578
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0108 0.01
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0011 0.0031
Brugia malayi DNA topoisomerase III 0.0072 0.0279 0.1321
Onchocerca volvulus 0.0027 0.0061 0.0163
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0182 0.0861
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0042 0.0198
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Schistosoma mansoni cpg binding protein 0.0032 0.0086 0.023
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0456 0.2109 0.5626
Mycobacterium ulcerans potassium/proton antiporter 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0239 0.0545
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0456 0.2109 0.8979
Echinococcus multilocularis lamin 0.0027 0.0061 0.0139
Echinococcus multilocularis microtubule associated protein 2 0.0799 0.3749 0.854
Echinococcus granulosus cpg binding protein 0.0032 0.0086 0.023
Plasmodium vivax SET domain protein, putative 0.0064 0.0239 0.0232
Mycobacterium ulcerans two component regulator - sensor kinase 0.0032 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0409 0.1883 0.5023
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0099 0.0225
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.01 0.0069
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.055 0.1252
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0084 0.0293
Schistosoma mansoni Slc9a7 protein 0.0019 0.0023 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.011
Plasmodium vivax DNA topoisomerase 3, putative 0.0072 0.0279 0.0271
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0042 0.0111
Loa Loa (eye worm) sodium-hydrogen exchanger NHE1 0.0019 0.0023 0.011
Brugia malayi Cytochrome P450 family protein 0.0052 0.0182 0.0863
Leishmania major developmentally regulated phosphoprotein-like protein 0.0032 0.0084 0.0223
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0383 0.1763 0.4669
Schistosoma mansoni hypothetical protein 0.0052 0.0182 0.0485
Leishmania major hypothetical protein, conserved 0.0032 0.0084 0.0223
Mycobacterium leprae probable conserved integral membrane transport protein 0.0019 0.0023 0.0049

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.061 uM In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibition ChEMBL. 12086486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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