Detailed information for compound 170270

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 398.717 | Formula: C17H18Cl3N5--
  • H donors: 2 H acceptors: 1 LogP: 4.07 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C1CC(=NN=C(N)N)c2c(C1)nccc2C.[Cl-].[Cl-]
  • InChi: 1S/C17H18ClN5.2ClH/c1-10-5-6-21-14-8-12(11-3-2-4-13(18)7-11)9-15(16(10)14)22-23-17(19)20;;/h2-7,12H,8-9H2,1H3,(H4,19,20,23);2*1H/p-2/b22-15+;;
  • InChiKey: MAUOBGCJCPUQQL-IFGMWRHRSA-L  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.0408 0.093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0165 0.072 0.3414
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0182 0.0861
Mycobacterium ulcerans DNA gyrase subunit A 0.2109 1 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.0268 0.0714
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.01 0.0069
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0032 0.0084 0.0223
Leishmania major pteridine reductase 1 0.0021 0.0032 0.0085
Chlamydia trachomatis oxoacyl-ACP synthase III 0.1245 0.5876 0.5841
Mycobacterium ulcerans membrane transporter 0.0019 0.0023 0.0023
Loa Loa (eye worm) NHE-3 0.01 0.0408 0.1936
Plasmodium falciparum heat shock protein 90 0.0032 0.0084 0.0077
Giardia lamblia Sodium/hydrogen exchanger 3 0.01 0.0408 0.1729
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0084 0.0223
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0008 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0934 0.4391 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.0233 0.0622
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0032 0.0084 0.0084
Brugia malayi heat shock protein 90 0.0032 0.0084 0.04
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0309 0.0824
Trypanosoma brucei DNA topoisomerase IA, putative 0.0072 0.0279 0.0738
Plasmodium falciparum DNA topoisomerase 2 0.0456 0.2109 0.2103
Mycobacterium ulcerans glutaminase 0.0266 0.1202 0.1202
Plasmodium vivax SET domain protein, putative 0.0064 0.0239 0.0232
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0032 0.0084 0.0084
Trypanosoma cruzi DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0032 0.0084 0.0084
Brugia malayi Pre-SET motif family protein 0.0064 0.0239 0.1135
Schistosoma mansoni inositol monophosphatase 0.0079 0.0309 0.0824
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.01 0.0228
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0084 0.0084
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0164 0.0718 0.3403
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.055 0.055
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0084 0.0223
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0084 0.04
Leishmania major hypothetical protein, conserved 0.0032 0.0084 0.0223
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0032 0.0084 0.0192
Echinococcus granulosus heat shock protein 0.0032 0.0084 0.0225
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0008 0.0021
Toxoplasma gondii DNA topoisomerase family protein 0.0072 0.0279 0.0279
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.1014 0.4775 0.473
Onchocerca volvulus 0.0035 0.01 0.0331
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.0408 0.093
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.01 0.0475
Mycobacterium ulcerans DNA topoisomerase I 0.0072 0.0279 0.0279
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0032 0.0084 0.0061
Brugia malayi GRF zinc finger family protein 0.0072 0.0279 0.1321
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.0268 0.0268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0397 0.0905
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0032 0.0084 0.0061
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.055 0.1466
Onchocerca volvulus 0.0027 0.0061 0.0163
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.055 0.1455
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.0408 0.1089
Mycobacterium leprae probable conserved integral membrane transport protein 0.0019 0.0023 0.0049
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0084 0.0223
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.0471 0.2232
Trypanosoma cruzi DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0309 0.0993
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0309 0.137
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0032 0.0084 0.0225
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0217 0.0578
Schistosoma mansoni microtubule-associated protein tau 0.0799 0.3749 1
Schistosoma mansoni hypothetical protein 0.0409 0.1883 0.5023
Schistosoma mansoni hypothetical protein 0.0186 0.0821 0.2191
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.01 0.01
Schistosoma mansoni zinc finger protein 0.0021 0.0031 0.0083
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0032 0.0084 0.0084
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0182 0.0863
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.007 0.0268 0.1269
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0072 0.0279 0.1321
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0021
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0032 0.0084 0.0084
Leishmania major hypothetical protein, conserved 0.0035 0.01 0.0265
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0069 0.0329
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0099 0.0264
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0032 0.0084 0.0084
Schistosoma mansoni heat shock protein 0.0032 0.0084 0.0225
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0182 0.0414
Mycobacterium ulcerans short chain dehydrogenase 0.0021 0.0032 0.0032
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Trichomonas vaginalis glutaminase, putative 0.0266 0.1202 0.4942
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0008 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0165 0.072 0.3414
Mycobacterium tuberculosis Conserved protein 0.0035 0.01 0.01
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.055 0.1466
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0653
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0084 0.0223
Brugia malayi Bromodomain containing protein 0.0037 0.011 0.0521
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.055 0.1466
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0318 0.0725
Schistosoma mansoni pyruvate dehydrogenase 0.0032 0.0084 0.0225
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.2109 1 1
Echinococcus multilocularis muscleblind protein 1 0.0164 0.0716 0.1631
Loa Loa (eye worm) hypothetical protein 0.0165 0.072 0.3414
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0186 0.0822 0.0814
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0108 0.0105
Schistosoma mansoni ap endonuclease 0.0037 0.0108 0.0289
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0032 0.0084 0.0084
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0805 0.3776 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0061 0.0163
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0042 0.0042
Schistosoma mansoni endoplasmin 0.0032 0.0084 0.0225
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.0408 0.1089
Mycobacterium leprae conserved hypothetical protein 0.0035 0.01 0.0212
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0011 0.0031
Entamoeba histolytica DNA topoisomerase III, putative 0.0072 0.0279 0.1224
Leishmania major oxidoreductase-like protein 0.0021 0.0032 0.0085
Loa Loa (eye worm) sodium-hydrogen exchanger NHE1 0.0019 0.0023 0.011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0234 0.0625
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.0408 0.093
Brugia malayi Pre-SET motif family protein 0.0444 0.2054 0.9737
Chlamydia trachomatis DNA gyrase subunit A 0.0219 0.0978 0.0901
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0032 0.0084 0.0084
Plasmodium falciparum endoplasmin, putative 0.0032 0.0084 0.0077
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0456 0.2109 0.8979
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0349 0.16 0.3381
Schistosoma mansoni lamin 0.0027 0.0061 0.0163
Giardia lamblia DNA topoisomerase III 0.0072 0.0279 0.1037
Trichomonas vaginalis esterase, putative 0.0035 0.01 0.0069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0217 0.0494
Brugia malayi intermediate filament protein 0.0027 0.0061 0.029
Trypanosoma brucei DNA topoisomerase ii 0.0805 0.3776 1
Toxoplasma gondii ABC1 family protein 0.0035 0.01 0.01
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0239 0.0545
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0072 0.0279 0.0743
Loa Loa (eye worm) hypothetical protein 0.0164 0.0718 0.3403
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0021
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0023 0.0053
Leishmania major hypothetical protein, conserved 0.0015 0.0003 0.0009
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0061 0.029
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.055 0.1252
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0108 0.0287
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0108 0.0289
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.0408 0.1089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0318 0.0849
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0108 0.0085
Trypanosoma brucei oxidoreductase-like protein 0.0021 0.0032 0.0085
Trichomonas vaginalis DNA topoisomerase II, putative 0.0456 0.2109 0.8952
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0108 0.0287
Onchocerca volvulus 0.0027 0.0061 0.0163
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0032 0.0084 0.0084
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.0019 0.0023 0.0062
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0021
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0023 0.0061
Plasmodium vivax DNA topoisomerase II, putative 0.0456 0.2109 0.2103
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0084 0.0084
Mycobacterium leprae Probable lipase LipE 0.0035 0.01 0.0212
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.0408 0.1089
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Onchocerca volvulus 0.0072 0.0279 0.1099
Chlamydia trachomatis DNA gyrase subunit B 0.1014 0.4775 0.473
Brugia malayi glutaminase DH11.1 0.0266 0.1202 0.57
Leishmania major Na/H antiporter-like protein 0.0019 0.0023 0.0061
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.007 0.0268 0.0714
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0383 0.1763 0.4669
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Loa Loa (eye worm) hypothetical protein 0.01 0.0408 0.1936
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0084 0.0223
Echinococcus multilocularis muscleblind protein 0.0164 0.0716 0.1631
Brugia malayi Muscleblind-like protein 0.0164 0.0716 0.3395
Plasmodium falciparum enoyl-acyl carrier reductase 0.0186 0.0822 0.0814
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0075 0.0289 0.1368
Giardia lamblia DNA topoisomerase III 0.0072 0.0279 0.1037
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0014 0.0068
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.0268 0.0268
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0108 0.0407
Echinococcus granulosus zinc finger protein 0.0021 0.0031 0.0083
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0023 0.0062
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.01 0.0069
Brugia malayi beta-lactamase 0.0035 0.01 0.0475
Mycobacterium tuberculosis Conserved protein 0.0035 0.01 0.01
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0397 0.106
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Loa Loa (eye worm) hypothetical protein 0.01 0.0408 0.1936
Plasmodium vivax sodium/hydrogen exchanger 1, putative 0.0019 0.0023 0.0015
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0108 0.0513
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.01 0.01
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0182 0.0861
Brugia malayi beta-lactamase family protein 0.0035 0.01 0.0475
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0182 0.0861
Echinococcus granulosus muscleblind protein 0.0164 0.0716 0.191
Schistosoma mansoni sodium/hydrogen exchanger 0.01 0.0408 0.1089
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0042 0.0111
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0397 0.1884
Leishmania major DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Mycobacterium ulcerans hypothetical protein 0.0035 0.01 0.01
Schistosoma mansoni inositol monophosphatase 0.0079 0.0309 0.0824
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0397 0.0905
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0456 0.2109 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0108 0.0105
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0108 0.0127
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0522
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0042 0.0198
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0023 0.0061
Brugia malayi Inositol-1 0.0079 0.0309 0.1465
Onchocerca volvulus 0.0029 0.0069 0.0199
Echinococcus multilocularis heat shock protein 0.0032 0.0084 0.0192
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.2109 1 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0309 0.0309
Plasmodium vivax DNA gyrase subunit A, putative 0.2109 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.055 0.055
Giardia lamblia DNA topoisomerase II 0.0424 0.1957 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0239 0.0239
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0397 0.1884
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0239 0.0638
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0061 0.029
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.0318 0.0723
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0084 0.0084
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0032 0.0084 0.0084
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1003 0.1003
Echinococcus granulosus cpg binding protein 0.0032 0.0086 0.023
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0456 0.2109 0.8979
Leishmania major hypothetical protein, conserved 0.0019 0.0023 0.0061
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.0408 0.1089
Echinococcus granulosus lamin dm0 0.0027 0.0061 0.0163
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.01 0.01
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0008 0.0008
Plasmodium vivax endoplasmin, putative 0.0032 0.0084 0.0077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0018
Schistosoma mansoni lamin 0.0027 0.0061 0.0163
Echinococcus granulosus geminin 0.0186 0.0821 0.2191
Schistosoma mansoni endoplasmin 0.0032 0.0084 0.0225
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0186 0.0822 0.1737
Loa Loa (eye worm) hypothetical protein 0.0219 0.0978 0.4636
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.01 0.0265
Trichomonas vaginalis set domain proteins, putative 0.0506 0.2347 1
Echinococcus granulosus GPCR family 2 0.0052 0.0182 0.0485
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.029
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.01 0.0267
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0182 0.0414
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0309 0.0704
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.01 0.0408 0.1936
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0309 0.0993
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.0408 0.1657
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.0318 0.0847
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0072 0.0279 0.0743
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0011 0.0031
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0108 0.01
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1245 0.5876 0.5876
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.1245 0.5876 0.5867
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0186 0.0822 0.0822
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.1883 0.429
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.0408 0.093
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0072 0.0279 0.0743
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0108 0.0287
Mycobacterium ulcerans DNA gyrase subunit B 0.1014 0.4775 0.4775
Toxoplasma gondii DNA topoisomerase 2, putative 0.0456 0.2109 0.2109
Loa Loa (eye worm) glutaminase 2 0.0266 0.1202 0.57
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0084 0.0077
Plasmodium falciparum DNA topoisomerase 3, putative 0.0072 0.0279 0.0271
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.0032 0.0032
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0186 0.0822 0.0744
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.01 0.0475
Onchocerca volvulus 0.0064 0.0239 0.093
Toxoplasma gondii sodium/hydrogen exchanger 3 protein 0.0019 0.0023 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.01 0.0267
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0084 0.0223
Brugia malayi Cytochrome P450 family protein 0.0052 0.0182 0.0863
Leishmania major DNA topoisomerase ii 0.0383 0.1763 0.4669
Plasmodium vivax DNA topoisomerase 3, putative 0.0072 0.0279 0.0271
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0239 0.0638
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0042 0.0198
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0099 0.0225
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.0019 0.0023 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.0799 0.3749 0.854
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.01 0.0265
Toxoplasma gondii exonuclease III APE 0.0037 0.0108 0.0108
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.1005 0.4732 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.0978 0.4636
Mycobacterium ulcerans ion antiporter, NhaP 0.0019 0.0023 0.0023
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0045 0.0119
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0021 0.0032 0.0085
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0072 0.0279 0.0256
Chlamydia trachomatis DNA topoisomerase I 0.0072 0.0279 0.0196
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.1014 0.4775 0.4762
Loa Loa (eye worm) DNA topoisomerase III 0.0072 0.0279 0.1321
Echinococcus multilocularis zinc finger protein 0.0021 0.0031 0.007
Schistosoma mansoni glutaminase 0.0266 0.1202 0.3207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0397 0.106
Schistosoma mansoni hypothetical protein 0.0052 0.0182 0.0485
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0108 0.0108
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.01 0.0069
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0084 0.0293
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0023 0.0061
Loa Loa (eye worm) hypothetical protein 0.0164 0.0716 0.3395
Mycobacterium ulcerans beta-lactamase 0.0035 0.01 0.01
Brugia malayi isocitrate dehydrogenase 0.0016 0.0008 0.0037
Brugia malayi Cytochrome P450 family protein 0.0023 0.0042 0.0198
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.055 0.055
Echinococcus multilocularis musashi 0.0027 0.0061 0.0139
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0164 0.0716 0.3395
Brugia malayi DNA topoisomerase III beta-1 0.0072 0.0279 0.1321
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0008 0.0018
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.1245 0.5876 0.5876
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0084 0.0077
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.027 0.027
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0032 0.0084 0.0084
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0186 0.0822 0.0822
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1014 0.4775 0.4775
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1245 0.5876 0.5876
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0001 0.0007
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.2109 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0042 0.0111
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0318 0.0849
Chlamydia trachomatis DNA gyrase subunit B 0.0665 0.3107 0.3049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0084 0.04
Mycobacterium ulcerans potassium/proton antiporter 0.0019 0.0023 0.0023
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0011 0.0026
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0032 0.0084 0.0084
Brugia malayi PHD-finger family protein 0.0026 0.0056 0.0264
Schistosoma mansoni DNA topoisomerase II 0.0456 0.2109 0.5626
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0042 0.0198
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0045 0.0119
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0032 0.0084 0.0084
Toxoplasma gondii sodium/hydrogen exchanger NHE2 0.0019 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.01 0.0265
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0042 0.0111
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.1245 0.5876 0.5873
Loa Loa (eye worm) hypothetical protein 0.004 0.0121 0.0574
Brugia malayi CXXC zinc finger family protein 0.0029 0.0069 0.0329
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0008 0.0008
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0032 0.0084 0.0084
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0008 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.01 0.0267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0397 0.106
Schistosoma mansoni cpg binding protein 0.0032 0.0086 0.023
Brugia malayi Cytochrome P450 family protein 0.0023 0.0042 0.0198
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.1245 0.5876 0.5873
Loa Loa (eye worm) hypothetical protein 0.01 0.0408 0.1936
Echinococcus granulosus heat shock protein 90 0.0032 0.0084 0.0225
Treponema pallidum DNA topoisomerase I (topA) 0.0072 0.0279 0.0196
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0309 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.055 0.055
Brugia malayi beta-lactamase family protein 0.0035 0.01 0.0475
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0019 0.0023 0.011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0309 0.0993
Mycobacterium tuberculosis Conserved protein 0.0035 0.01 0.01
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0008 0.0037
Trypanosoma brucei developmentally regulated phosphoprotein 0.0032 0.0084 0.0223
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0032 0.0084 0.0084
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Echinococcus multilocularis geminin 0.0186 0.0821 0.1871
Schistosoma mansoni Slc9a7 protein 0.0019 0.0023 0.0062
Toxoplasma gondii Na+/H+ exchanger NHE3 0.0019 0.0023 0.0023
Onchocerca volvulus 0.0021 0.0032 0.0038
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0032 0.0084 0.0077
Echinococcus granulosus microtubule associated protein 2 0.0799 0.3749 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0456 0.2109 0.4804
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0084 0.0223
Mycobacterium leprae Probable two-component sensor kinase 0.0032 0.0084 0.0178
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0165 0.072 0.3414
Toxoplasma gondii Na+/H+ exchanger NHE1 0.0019 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0052 0.0182 0.0485
Schistosoma mansoni cpg binding protein 0.0029 0.0069 0.0185
Plasmodium falciparum DNA gyrase subunit A 0.2109 1 1
Leishmania major DNA topoisomerase 1A 0.0072 0.0279 0.0738
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0108 0.0287
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0072 0.0279 0.0589
Leishmania major DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0018
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.01 0.0408 0.1936
Loa Loa (eye worm) inositol-1 0.0079 0.0309 0.1465
Brugia malayi DNA topoisomerase III 0.0072 0.0279 0.1321
Brugia malayi kinase, mitochondrial precursor 0.0032 0.0084 0.04
Plasmodium vivax DNA gyrase subunit B, putative 0.1014 0.4775 0.477
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.055 0.055
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0.0032 0.0032
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0309 0.0819
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0021 0.0032 0.0032
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.1245 0.5876 0.5876
Schistosoma mansoni hypothetical protein 0.0019 0.0023 0.0062
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0309 0.0819
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0186 0.0822 0.08
Leishmania major mitochondrial DNA topoisomerase II 0.0805 0.3776 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0108 0.01
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.011
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0032 0.0084 0.0084
Trypanosoma cruzi DNA topoisomerase II, putative 0.0383 0.1763 0.4669
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0444 0.2054 0.9737
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0028 0.0133
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0032 0.0084 0.0192
Echinococcus multilocularis cpg binding protein 0.0032 0.0086 0.0196
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0032 0.0084 0.0178
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.0268 0.061
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0072 0.0279 0.0738
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0023 0.0061
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0072 0.0279 0.0743
Mycobacterium leprae Probable two component sensor kinase MprB 0.0032 0.0084 0.0178
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.01 0.0069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0397 0.106
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0084 0.0223
Trypanosoma brucei DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Echinococcus multilocularis rho GTPase activating protein 20 0.0072 0.0279 0.0635
Schistosoma mansoni hypothetical protein 0.0052 0.0182 0.0485
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0186 0.0822 0.0822
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0072 0.0279 0.0859
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0309 0.0287
Mycobacterium ulcerans lipase LipD 0.0035 0.01 0.01
Loa Loa (eye worm) sodium/hydrogen exchanger 0.01 0.0408 0.1936
Brugia malayi Bromodomain containing protein 0.0074 0.0288 0.1364
Echinococcus multilocularis heat shock protein 90 0.0032 0.0084 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.011
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0084 0.0223
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0805 0.3776 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.01 0.0069
Mycobacterium ulcerans two component sensor kinase MprB 0.0032 0.0084 0.0084
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.0408 0.1657
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.01 0.0408 0.1089
Mycobacterium tuberculosis Conserved protein 0.0032 0.0084 0.0084
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0383 0.1763 0.4669
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0032 0.0084 0.0178
Loa Loa (eye worm) hypothetical protein 0.0113 0.0471 0.2232
Echinococcus multilocularis GPCR, family 2 0.0052 0.0182 0.0414
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0084 0.0223
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0318 0.0849
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0084 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0397 0.106
Loa Loa (eye worm) beta-lactamase 0.0035 0.01 0.0475
Schistosoma mansoni heat shock protein 0.0032 0.0084 0.0225
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.01 0.01
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0214 0.0214
Trichomonas vaginalis hypothetical protein 0.0186 0.0822 0.3259
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0456 0.2109 0.8979
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0182 0.0485
Onchocerca volvulus 0.0506 0.2347 1
Onchocerca volvulus 0.0035 0.01 0.0331
Plasmodium falciparum DNA gyrase subunit B 0.1014 0.4775 0.477
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.01 0.01
Brugia malayi Sodium/hydrogen exchanger 8 0.0019 0.0023 0.011
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.0408 0.093
Echinococcus granulosus sodium:hydrogen exchanger 7 0.0019 0.0023 0.0062
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0108 0.0247
Mycobacterium ulcerans two component regulator - sensor kinase 0.0032 0.0084 0.0084
Brugia malayi Probable DNA topoisomerase II 0.0456 0.2109 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0475
Echinococcus granulosus dnaJ subfamily B 0.0409 0.1883 0.5023
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0586 0.2731 0.2731
Schistosoma mansoni hypothetical protein 0.0186 0.0821 0.2191
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0309 0.0819
Schistosoma mansoni hypothetical protein 0.0019 0.0023 0.0062
Trypanosoma cruzi DNA topoisomerase II, putative 0.0383 0.1763 0.4669
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0225 0.06
Trypanosoma brucei DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Echinococcus multilocularis lamin dm0 0.0027 0.0061 0.0139
Entamoeba histolytica DNA topoisomerase III, putative 0.0072 0.0279 0.1224
Loa Loa (eye worm) TOPoisomerase family member 0.0456 0.2109 1
Schistosoma mansoni zinc finger protein 0.0015 0.0003 0.0009
Trypanosoma cruzi ISWI complex protein 0.0015 0.0003 0.0009
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0084 0.0293
Schistosoma mansoni hypothetical protein 0.0052 0.0182 0.0485
Leishmania major developmentally regulated phosphoprotein-like protein 0.0032 0.0084 0.0223
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.027 0.057
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0072 0.0279 0.0279
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0021 0.0032 0.0032
Echinococcus granulosus lamin 0.0027 0.0061 0.0163
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0032 0.0084 0.0084
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.01 0.01
Echinococcus multilocularis lamin 0.0027 0.0061 0.0139
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0009
Plasmodium falciparum sodium/hydrogen exchanger, Na+, H+ antiporter 0.0019 0.0023 0.0015
Brugia malayi hypothetical protein 0.0019 0.0023 0.011
Entamoeba histolytica DNA topoisomerase II, putative 0.0456 0.2109 1
Loa Loa (eye worm) endoplasmin 0.0032 0.0084 0.04
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0045 0.0102
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0108 0.0024
Mycobacterium ulcerans putative regultory protein 0.0032 0.0084 0.0084
Mycobacterium tuberculosis Possible two component sensor kinase 0.0032 0.0084 0.0084
Mycobacterium tuberculosis Probable two component sensor kinase 0.0032 0.0084 0.0084
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0011 0.0031
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0279
Trypanosoma brucei ISWI complex protein 0.0015 0.0003 0.0009
Loa Loa (eye worm) glutaminase 0.0266 0.1202 0.57
Plasmodium vivax hypothetical protein, conserved 0.0035 0.01 0.0092
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0309 0.0819
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0072 0.0279 0.0738
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0072 0.0279 0.0635
Schistosoma mansoni hypothetical protein 0.002 0.0028 0.0075
Entamoeba histolytica fatty acid elongase, putative 0.0162 0.0704 0.3265
Loa Loa (eye worm) hypothetical protein 0.0069 0.026 0.1233
Schistosoma mansoni cpg binding protein 0.0032 0.0086 0.023
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0456 0.2109 0.5626
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0072 0.0279 0.0859
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0108 0.0513
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0018
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0061 0.029
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.01 0.01
Trypanosoma brucei heat shock protein, putative 0.0032 0.0084 0.0223
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.0268 0.0268
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0456 0.2109 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0182 0.0861
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Loa Loa (eye worm) hypothetical protein 0.0081 0.0318 0.1509
Leishmania major heat shock protein 83-1 0.0032 0.0084 0.0223
Leishmania major cytochrome p450-like protein 0.0023 0.0042 0.0111
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0108 0.0108
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.2109 1 1
Brugia malayi Endoplasmin precursor 0.0032 0.0084 0.04
Trypanosoma cruzi DNA topoisomerase III, putative 0.0072 0.0279 0.0738
Echinococcus granulosus intermediate filament protein 0.0027 0.0061 0.0163
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.007 0.0268 0.0709
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0182 0.0485
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.01 0.01
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0021 0.0032 0.0032
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0019 0.0023 0.0023
Onchocerca volvulus 0.0035 0.01 0.0331
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0032 0.0084 0.0084
Mycobacterium tuberculosis Probable conserved integral membrane transport protein YjcE 0.0019 0.0023 0.0023
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.0408 0.1657
Trypanosoma cruzi ISWI complex protein 0.0015 0.0003 0.0009
Schistosoma mansoni ap endonuclease 0.0037 0.0108 0.0289
Schistosoma mansoni hypothetical protein 0.0113 0.0471 0.1256

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.061 uM In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibition ChEMBL. 12086486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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