Detailed information for compound 1735616

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 475.421 | Formula: C22H20F3N5O4
  • H donors: 2 H acceptors: 4 LogP: 1.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC1CCN(C/C/1=N\OC)c1nc2c(cc1F)c(=O)c(cn2c1ccc(cc1F)F)C(=O)O
  • InChi: 1S/C22H20F3N5O4/c1-26-16-5-6-29(10-17(16)28-34-2)21-15(25)8-12-19(31)13(22(32)33)9-30(20(12)27-21)18-4-3-11(23)7-14(18)24/h3-4,7-9,16,26H,5-6,10H2,1-2H3,(H,32,33)/b28-17+
  • InChiKey: OAWIFSNYTYLOTN-OGLMXYFKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0131 0.0191 0.1032
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0131 0.0191 0.0436
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0092 0.0337
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.003 0.0219
Schistosoma mansoni nuclear receptor 0.0208 0.0327 0.0323
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.003 0.0219
Loa Loa (eye worm) oxidoreductase 0.0038 0.0027 0.0146
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0181 0.0278 0.1041
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Entamoeba histolytica fatty acid elongase, putative 0.0296 0.0482 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0182 0.0281 0.1521
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0441 0.0738 0.2785
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.0281 0.1052
Onchocerca volvulus 0.0131 0.0191 0.2323
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.024 0.1242
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0027 0.3541
Echinococcus multilocularis ecdysone induced protein 78C 0.0441 0.0738 0.2785
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0038 0.0027 0.0024
Echinococcus granulosus Nuclear hormone receptor HR96 0.0208 0.0327 0.1225
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0208 0.0327 0.4229
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0131 0.0191 0.9691
Brugia malayi beta-lactamase family protein 0.0037 0.0025 0.0066
Brugia malayi Nuclear hormone receptor E75 0.0208 0.0327 0.1712
Schistosoma mansoni RAR-like nuclear receptor 0.0441 0.0738 0.0735
Entamoeba histolytica hypothetical protein 0.0075 0.0092 0.1431
Onchocerca volvulus 0.0222 0.0352 0.4581
Echinococcus multilocularis nuclear receptor nhr 48 0.0208 0.0327 0.1225
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0038 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0101 0.0138 0.0748
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.003 0.4412
Schistosoma mansoni nuclear receptor nhr-48 0.0208 0.0327 0.0323
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0052 1
Schistosoma mansoni hypothetical protein 0.0032 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0181 0.0278 0.1505
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0038 0.0027 0.009
Brugia malayi Bromodomain containing protein 0.0044 0.0036 0.0128
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0071
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0238
Brugia malayi hypothetical protein 0.0031 0.0013 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0016 0.0016
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.003 0.0103
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0441 0.0738 0.2785
Loa Loa (eye worm) hypothetical protein 0.0233 0.0371 0.2007
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0027 0.0078
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.0225 0.0841
Brugia malayi nuclear receptor NHR-67 0.0208 0.0327 0.1712
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.003 0.286
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0038 0.0027 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0441 0.0738 0.0735
Echinococcus granulosus BC026374 protein S09 family 0.0181 0.0278 0.1041
Echinococcus granulosus neuropeptide receptor A26 0.0483 0.0813 0.3068
Brugia malayi TAZ zinc finger family protein 0.0112 0.0156 0.0783
Onchocerca volvulus 0.0038 0.0027 0.003
Loa Loa (eye worm) carboxylesterase 0.0181 0.0278 0.1505
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0047 0.0874
Echinococcus multilocularis acetylcholinesterase 0.1068 0.1846 0.6986
Loa Loa (eye worm) hypothetical protein 0.0222 0.0352 0.1905
Schistosoma mansoni retinoic acid receptor RXR 0.0441 0.0738 0.0735
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0233 0.0371 0.2007
Onchocerca volvulus 0.005 0.0048 0.0321
Echinococcus multilocularis thyroid hormone receptor alpha 0.0441 0.0738 0.2785
Loa Loa (eye worm) hypothetical protein 0.0098 0.0132 0.0715
Brugia malayi hypothetical protein 0.0208 0.0327 0.1712
Onchocerca volvulus 0.0181 0.0278 0.3547
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0441 0.0738 0.2785
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Brugia malayi hypothetical protein 0.0233 0.0371 0.1952
Onchocerca volvulus 0.0038 0.0027 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0441 0.0738 0.3998
Schistosoma mansoni bromodomain containing protein 0.0069 0.008 0.0077
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0038 0.0027 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0441 0.0738 0.3956
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0025 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0016 0.0047
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0016 0.0047
Loa Loa (eye worm) nuclear receptor NHR-67 0.0208 0.0327 0.1769
Mycobacterium tuberculosis Probable reductase 0.0121 0.0172 0.0389
Mycobacterium ulcerans acyl-CoA synthetase 0.0131 0.0191 0.0418
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0052 0.0088
Loa Loa (eye worm) hypothetical protein 0.0069 0.0081 0.0441
Schistosoma mansoni nuclear hormone receptor 0.0441 0.0738 0.0735
Onchocerca volvulus 0.0038 0.0027 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0441 0.0738 0.3956
Loa Loa (eye worm) hypothetical protein 0.0098 0.0132 0.0715
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0169 0.0258 0.0255
Brugia malayi Carboxylesterase family protein 0.0181 0.0278 0.1446
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0441 0.0738 0.2785
Brugia malayi nuclear receptor NHR-88 0.0441 0.0738 0.3956
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0038 0.0027 0.0024
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0131 0.0191 0.0418
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.0196 0.0449
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0441 0.0738 0.2785
Echinococcus multilocularis carboxylesterase 5A 0.1068 0.1846 0.6986
Schistosoma mansoni hypothetical protein 0.0075 0.0092 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0081 0.0375
Entamoeba histolytica fatty acid elongase, putative 0.0296 0.0482 1
Schistosoma mansoni nuclear hormone receptor 0.0208 0.0327 0.0323
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.0281 0.1052
Mycobacterium ulcerans acetyl-CoA synthetase 0.0038 0.0027 0.0005
Onchocerca volvulus 0.0181 0.0278 0.3547
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0441 0.0738 0.3956
Leishmania major acetyl-CoA synthetase, putative 0.0038 0.0027 0.0785
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0233 0.0371 0.0367
Echinococcus granulosus FTZ F1 alpha 0.0441 0.0738 0.2785
Echinococcus granulosus nuclear receptor nhr 48 0.0208 0.0327 0.1225
Brugia malayi Nuclear hormone receptor-like 1 0.0441 0.0738 0.3956
Schistosoma mansoni hypothetical protein 0.0032 0.0016 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0074 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0441 0.0738 0.3956
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0169 0.0258 0.0255
Plasmodium vivax acyl-CoA synthetase, putative 0.0098 0.0132 0.0299
Loa Loa (eye worm) hypothetical protein 0.0157 0.0237 0.1282
Loa Loa (eye worm) hypothetical protein 0.0098 0.0132 0.0715
Brugia malayi hypothetical protein 0.0157 0.0237 0.1222
Loa Loa (eye worm) steroid hormone receptor 0.0441 0.0738 0.3998
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0038 0.0027 0.0005
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0146
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0025 0.0018
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0038 0.0027 0.3541
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.0196 0.0449
Plasmodium falciparum acyl-CoA synthetase 0.0098 0.0132 0.0299
Entamoeba histolytica acyl-CoA synthetase, putative 0.0131 0.0191 0.3593
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0027 0.0146
Schistosoma mansoni CREB-binding protein 2 0.0112 0.0156 0.0153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0123 0.0265
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0038 0.0027 0.0005
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0208 0.0327 0.1225
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0208 0.0327 0.1712
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0208 0.0327 0.4229
Echinococcus multilocularis BC026374 protein (S09 family) 0.0181 0.0278 0.1041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0025 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0027 0.0005
Schistosoma mansoni survival motor neuron protein 0.005 0.0048 0.0044
Trichomonas vaginalis spcc417.12 protein, putative 0.0181 0.0278 1
Brugia malayi beta-lactamase 0.0037 0.0025 0.0066
Brugia malayi orphan nuclear receptor NR2E1 0.0208 0.0327 0.1712
Plasmodium vivax acetyl-CoA synthetase, putative 0.0038 0.0027 0.0035
Plasmodium falciparum glutathione reductase 0.0053 0.0052 0.0099
Brugia malayi Cytochrome P450 family protein 0.0033 0.0018 0.0027
Entamoeba histolytica acyl-coA synthetase, putative 0.0131 0.0191 0.3593
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0441 0.0738 0.0735
Entamoeba histolytica fatty acid elongase, putative 0.0296 0.0482 1
Schistosoma mansoni hypothetical protein 0.0032 0.0016 0.0012
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0131 0.0191 0.0418
Loa Loa (eye worm) hypothetical protein 0.0131 0.0191 0.1032
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0025 0.3002
Brugia malayi photoreceptor-specific nuclear receptor 0.0441 0.0738 0.3956
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0038 0.0027 0.0005
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0027 0.0024
Brugia malayi nuclear hormone receptor family member nhr-6 0.0208 0.0327 0.1712
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0441 0.0738 0.2785
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0181 0.0278 0.0275
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0038 0.0027 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0131 0.0191 0.097
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.003 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0027 0.0078
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0052 0.0186
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.2281 0.3989 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0047 0.0165
Brugia malayi ecdysone receptor 0.0208 0.0327 0.1712
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.003 0.0103
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.2281 0.3989 0.5
Loa Loa (eye worm) hypothetical protein 0.0246 0.0394 0.2135
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0441 0.0738 0.3956
Brugia malayi Carboxylesterase family protein 0.0181 0.0278 0.1446
Loa Loa (eye worm) hypothetical protein 0.0441 0.0738 0.3998
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0181 0.0278 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.003 0.4412
Trichomonas vaginalis antibiotic synthetase, putative 0.0038 0.0027 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0441 0.0738 0.3956
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0441 0.0738 0.3956
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0208 0.0327 0.1769
Echinococcus granulosus GPCR family 2 0.0032 0.0016 0.0047
Echinococcus granulosus thyroid hormone receptor alpha 0.0208 0.0327 0.1225
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0098 0.0132 0.027
Brugia malayi conserved hypotetical protein 0.0208 0.0327 0.1712
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0208 0.0327 0.1225
Onchocerca volvulus 0.0181 0.0278 0.3547
Onchocerca volvulus 0.0038 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.003 0.0219
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0047 0.0085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0135
Entamoeba histolytica fatty acid elongase, putative 0.0296 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0143
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0441 0.0738 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.003 0.0219
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0038 0.0027 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0027 0.0005
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0038 0.0027 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0131 0.0191 0.097
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0123 0.0265
Trypanosoma brucei glucosidase, putative 0.004 0.003 0.4412
Echinococcus multilocularis FTZ F1 alpha 0.0441 0.0738 0.2785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0131 0.0191 0.0436
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0025 0.0018
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0038 0.0027 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0441 0.0738 0.2785
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.2281 0.3989 1
Echinococcus multilocularis CREB binding protein 0.0079 0.0098 0.0358
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0441 0.0738 0.2785
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.0196 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0027 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0138 0.0684
Loa Loa (eye worm) DR-78 0.0208 0.0327 0.1769
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0027 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0027 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.0172 0.0389
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0038 0.0027 0.0024
Echinococcus granulosus para nitrobenzyl esterase 0.0181 0.0278 0.1041
Schistosoma mansoni steroid hormone receptor ad4bp 0.0441 0.0738 0.0735
Schistosoma mansoni alpha-glucosidase 0.0157 0.0236 0.0233
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0074 0.0123
Brugia malayi nuclear hormone receptor family member odr-7 0.0208 0.0327 0.1712
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0441 0.0738 0.3998
Echinococcus granulosus Nuclear hormone receptor HR96 0.0208 0.0327 0.1225
Loa Loa (eye worm) hypothetical protein 0.0181 0.0278 0.1505
Schistosoma mansoni alpha-glucosidase 0.0157 0.0236 0.0233
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0138 0.0748
Toxoplasma gondii ABC1 family protein 0.0037 0.0025 0.1946
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0016 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0123 0.0265
Loa Loa (eye worm) acetyltransferase 0.0159 0.024 0.1302
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0038 0.0027 0.0035
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0038 0.0027 0.0078
Brugia malayi Glycosyl hydrolases family 31 protein 0.0182 0.0281 0.1463
Mycobacterium ulcerans acyl-CoA synthetase 0.0131 0.0191 0.0418
Mycobacterium ulcerans hypothetical protein 0.0131 0.0191 0.0418
Brugia malayi Carboxylesterase family protein 0.1068 0.1846 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.0371 0.2007
Loa Loa (eye worm) CBP-B 0.0079 0.0099 0.0538
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0233 0.0371 0.1392
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0208 0.0327 0.1225
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0052 0.0186
Schistosoma mansoni hypothetical protein 0.0032 0.0016 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0233 0.0371 0.1952
Brugia malayi nuclear receptor NHR-88 0.0208 0.0327 0.1712
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Chlamydia trachomatis oxoacyl-ACP synthase III 0.2281 0.3989 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0181 0.0278 0.0638
Leishmania major alpha glucosidase II subunit, putative 0.004 0.003 0.0978
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.0172 0.0389
Schistosoma mansoni thyroid hormone receptor 0.0441 0.0738 0.0735
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.1068 0.1846 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0022 0.0071
Echinococcus granulosus tumor protein p63 0.1518 0.2642 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.0172 0.0389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0441 0.0738 0.3998
Brugia malayi Nuclear hormone receptor E75 0.0208 0.0327 0.1712
Loa Loa (eye worm) hypothetical protein 0.0441 0.0738 0.3998
Onchocerca volvulus 0.0169 0.0258 0.3265
Brugia malayi nuclear receptor RXR 0.0233 0.0371 0.1952
Brugia malayi hypothetical protein 0.0208 0.0327 0.1712
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0131 0.0191 0.0418
Brugia malayi Carboxylesterase family protein 0.1068 0.1846 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0441 0.0738 0.3956
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0441 0.0738 0.3956
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0038 0.0027 0.0124
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.003 0.0075
Brugia malayi hypothetical protein 0.0233 0.0371 0.1952
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0233 0.0371 0.0367
Loa Loa (eye worm) glutathione reductase 0.0053 0.0052 0.0284
Schistosoma mansoni acetylcholinesterase 0.0181 0.0278 0.0275
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0169 0.0258 0.0964
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0052 0.0099
Loa Loa (eye worm) hypothetical protein 0.007 0.0083 0.0451
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0038 0.0027 0.009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0025 0.0066
Loa Loa (eye worm) pip kinase 2 0.0169 0.0258 0.1396
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.003 0.0219
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0047 0.5588
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0181 0.0278 0.0656
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0025 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0441 0.0738 0.2785
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0907 0.1561 0.5905
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.0172 0.0389
Entamoeba histolytica hypothetical protein 0.0075 0.0092 0.1431
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0047 0.5588
Schistosoma mansoni neuroligin 3 (S09 family) 0.0181 0.0278 0.0275
Onchocerca volvulus Bile acid receptor homolog 0.0441 0.0738 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0025 0.0082
Brugia malayi tailless protein 0.0208 0.0327 0.1712
Toxoplasma gondii thioredoxin reductase 0.0053 0.0052 0.6483
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0181 0.0278 0.0275
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0208 0.0327 0.1225
Schistosoma mansoni nuclear receptor 0.0208 0.0327 0.0323
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0181 0.0278 0.0656
Onchocerca volvulus 0.0208 0.0327 0.4229
Schistosoma mansoni coup transcription factor 0.0441 0.0738 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0441 0.0738 0.3956
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0135
Schistosoma mansoni gliotactin 0.0181 0.0278 0.0275
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0074 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0025 0.003
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.0394 0.1481
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0038 0.0027 0.2296
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0135
Loa Loa (eye worm) hypothetical protein 0.0098 0.0132 0.0715
Loa Loa (eye worm) carboxylesterase 0.0181 0.0278 0.1505
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0027 0.0785
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0181 0.0278 1
Loa Loa (eye worm) acetylcholinesterase 1 0.1068 0.1846 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0132 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0441 0.0738 0.3956
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0074 0.007
Brugia malayi AMP-binding enzyme family protein 0.0131 0.0191 0.097
Echinococcus granulosus carboxylesterase 5A 0.1068 0.1846 0.6986
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0441 0.0738 0.3998
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0027 0.0024
Brugia malayi ecdysteroid receptor 0.0441 0.0738 0.3956
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0027 0.0124
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.024 0.0898
Loa Loa (eye worm) nuclear hormone receptor 0.0208 0.0327 0.1769
Loa Loa (eye worm) hypothetical protein 0.0181 0.0278 0.1505
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0074 0.0267
Loa Loa (eye worm) hypothetical protein 0.0131 0.0191 0.1032
Echinococcus granulosus acetylcholinesterase 0.1068 0.1846 0.6986
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0092 0.0089
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.003 0.0165
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0074 0.342
Mycobacterium tuberculosis Carboxylesterase LipT 0.0181 0.0278 0.0656
Leishmania major hypothetical protein, conserved 0.0037 0.0025 0.0666
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0038 0.0027 0.3541
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0033 0.0129
Leishmania major acetyl-CoA synthetase, putative 0.0038 0.0027 0.0785
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0441 0.0738 0.0735
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0135
Schistosoma mansoni BC026374 protein (S09 family) 0.0181 0.0278 0.0275
Brugia malayi follicle stimulating hormone receptor 0.0235 0.0374 0.1971
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0074 0.0267
Schistosoma mansoni hypothetical protein 0.005 0.0048 0.0044
Toxoplasma gondii propionate-CoA ligase 0.0038 0.0027 0.2296
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0138 0.0684
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.003 0.0219
Echinococcus multilocularis para nitrobenzyl esterase 0.0181 0.0278 0.1041
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0018 0.0096
Loa Loa (eye worm) hypothetical protein 0.0441 0.0738 0.3998
Entamoeba histolytica hypothetical protein 0.0075 0.0092 0.1431
Echinococcus multilocularis GPCR, family 2 0.0032 0.0016 0.0047
Loa Loa (eye worm) hypothetical protein 0.0181 0.0278 0.1505
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0027 0.0005
Loa Loa (eye worm) hypothetical protein 0.1068 0.1846 1
Brugia malayi Nuclear hormone receptor-like 1 0.0233 0.0371 0.1952
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.003 0.0219
Echinococcus granulosus lysosomal alpha glucosidase 0.0182 0.0281 0.1052
Brugia malayi Carboxylesterase family protein 0.0181 0.0278 0.1446
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0208 0.0327 0.1225
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.0252
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0027 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0027 0.0005
Brugia malayi nuclear hormone receptor 0.0208 0.0327 0.1712
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.0374 0.2026
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0027 0.0005
Onchocerca volvulus 0.0105 0.0145 0.1687
Brugia malayi hypothetical protein 0.0246 0.0394 0.208
Loa Loa (eye worm) hypothetical protein 0.0441 0.0738 0.3998
Loa Loa (eye worm) hypothetical protein 0.0233 0.0371 0.2007
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.0172 0.0389
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0033 0.005
Echinococcus multilocularis neuroligin 0.0181 0.0278 0.1041
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.0196 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.2281 0.3989 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0025 0.0135
Loa Loa (eye worm) hypothetical protein 0.0181 0.0278 0.1505
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0208 0.0327 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0441 0.0738 0.3956
Trypanosoma brucei trypanothione reductase 0.0053 0.0052 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0027 0.3541
Brugia malayi nuclear receptor RXR 0.0208 0.0327 0.1712
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0441 0.0738 0.2785
Brugia malayi Pip kinase protein 2 0.0169 0.0258 0.1336
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1068 0.1846 0.1844
Onchocerca volvulus Protein ultraspiracle homolog 0.0441 0.0738 1
Brugia malayi hypothetical protein 0.0075 0.0092 0.0433
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0441 0.0738 0.2785
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0441 0.0738 0.2785
Echinococcus multilocularis acetylcholinesterase 0.1068 0.1846 0.6986
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0025 0.3002
Mycobacterium tuberculosis Conserved protein 0.0037 0.0025 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0123 0.0265
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0027 0.0024
Leishmania major trypanothione reductase 0.0053 0.0052 0.2217
Plasmodium vivax glutathione reductase, putative 0.0053 0.0052 0.0099
Schistosoma mansoni hypothetical protein 0.0069 0.0081 0.0078
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.024 0.0237
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0025 0.3002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0025 0.0135
Loa Loa (eye worm) hypothetical protein 0.0032 0.0016 0.0085
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0074 0.0267
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0074 0.0123
Schistosoma mansoni acetyl-CoA synthetase 0.0038 0.0027 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.0441 0.0738 0.2785
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0027 0.0146
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0098 0.0132 0.0288
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.0441 0.0738 0.3998
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0027 0.0078
Echinococcus granulosus neuroligin 0.0181 0.0278 0.1041
Schistosoma mansoni cellular tumor antigen P53 0.0222 0.0352 0.0348
Echinococcus granulosus acetylcholinesterase 0.1068 0.1846 0.6986
Echinococcus granulosus CREB binding protein 0.0071 0.0085 0.0309
Loa Loa (eye worm) hypothetical protein 0.0233 0.0371 0.2007
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.0394 0.1481
Leishmania major 4-coumarate:coa ligase-like protein 0.0131 0.0191 1
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.2281 0.3989 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0038 0.0027 0.3541
Brugia malayi beta-lactamase family protein 0.0037 0.0025 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0131 0.0191 0.0418
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0038 0.0027 0.0024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0441 0.0738 0.0735
Loa Loa (eye worm) hypothetical protein 0.0046 0.0041 0.0219
Entamoeba histolytica hypothetical protein 0.0075 0.0092 0.1431
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0038 0.0027 0.0005
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Plasmodium falciparum thioredoxin reductase 0.0053 0.0052 0.0099
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0038 0.0027 0.0005
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.2281 0.3989 1
Brugia malayi Thioredoxin reductase 0.0053 0.0052 0.0217
Loa Loa (eye worm) hypothetical protein 0.0441 0.0738 0.3998
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.003 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0441 0.0738 0.3998
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0441 0.0738 0.2785
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0441 0.0738 0.3998
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0033 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0092 0.0337
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0016 0.0047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0131 0.0191 0.3593
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.038 0.0912
Schistosoma mansoni zinc finger protein 0.0208 0.0327 0.0323
Onchocerca volvulus 0.0208 0.0327 0.4229
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.0172 0.8609
Brugia malayi nuclear hormone receptor 0.0441 0.0738 0.3956
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0441 0.0738 0.0735
Echinococcus granulosus CREB binding protein 0.0112 0.0156 0.058
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0181 0.0278 0.1041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.003 0.0219
Loa Loa (eye worm) hypothetical protein 0.0441 0.0738 0.3998
Schistosoma mansoni alpha glucosidase 0.004 0.003 0.0027
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0022 0.0071
Mycobacterium tuberculosis Conserved protein 0.0037 0.0025 0.0018
Onchocerca volvulus 0.0157 0.0237 0.297
Leishmania major 4-coumarate:coa ligase-like protein 0.0131 0.0191 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0131 0.0191 0.0418
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0074 0.0267
Echinococcus multilocularis neuropeptide s receptor 0.0483 0.0813 0.3068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0135
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0027 0.2296
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0025 0.0082
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0146
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0233 0.0371 0.1392
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0052 0.0284
Brugia malayi Carboxylesterase family protein 0.0181 0.0278 0.1446
Loa Loa (eye worm) hypothetical protein 0.0233 0.0371 0.2007
Brugia malayi Steroid receptor seven-up type 2 0.0441 0.0738 0.3956
Loa Loa (eye worm) hypothetical protein 0.0441 0.0738 0.3998
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0048 0.0191
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0074 0.0142
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0441 0.0738 0.0735
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0208 0.0327 0.1225
Loa Loa (eye worm) hypothetical protein 0.0181 0.0278 0.1505
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0441 0.0738 0.3956
Trichomonas vaginalis antibiotic synthetase, putative 0.0038 0.0027 0.0084
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.2281 0.3989 1
Onchocerca volvulus 0.0181 0.0278 0.3547
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0016 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0131 0.0191 1
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0169 0.0258 0.0964
Onchocerca volvulus 0.0181 0.0278 0.3547
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Loa Loa (eye worm) hypothetical protein 0.0169 0.0258 0.1396
Brugia malayi Bromodomain containing protein 0.008 0.0101 0.048
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0025 0.0018
Echinococcus multilocularis neuropeptide receptor A26 0.0483 0.0813 0.3068
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0027 0.0078
Echinococcus multilocularis tumor protein p63 0.1518 0.2642 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.003 0.0097
Loa Loa (eye worm) carboxylesterase 0.1068 0.1846 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0027 0.3541
Entamoeba histolytica fatty acid elongase, putative 0.0296 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.0278 0.1505
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0025 0.0018
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0208 0.0327 0.1225
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0074 0.0123
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0441 0.0738 0.0735
Brugia malayi steroid hormone receptor 0.0441 0.0738 0.3956
Mycobacterium tuberculosis Conserved protein 0.0037 0.0025 0.0018
Brugia malayi glutathione reductase 0.0053 0.0052 0.0217
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0047 0.0874
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0027 0.0078
Schistosoma mansoni nuclear hormone receptor 0.0208 0.0327 0.0323
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0112 0.0156 0.0153
Onchocerca volvulus 0.0441 0.0738 1
Brugia malayi hypothetical protein 0.0181 0.0278 0.1446
Loa Loa (eye worm) hypothetical protein 0.0208 0.0327 0.1769
Echinococcus granulosus neuropeptide s receptor 0.0483 0.0813 0.3068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0441 0.0738 0.3998
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0016 0.0047
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0131 0.0191 0.9691

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 128 ug ml-1 Antibacterial activity against extended-spectrum beta-lactamase-producing Escherichia coli isolate 12-2 ChEMBL. 23402878

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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