Detailed information for compound 1755482

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 393.823 | Formula: C21H16ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 4.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Oc1ccc(cc1)Cl)C)Nc1ccc2c(c1)nc(o2)c1ccncc1
  • InChi: 1S/C21H16ClN3O3/c1-13(27-17-5-2-15(22)3-6-17)20(26)24-16-4-7-19-18(12-16)25-21(28-19)14-8-10-23-11-9-14/h2-13H,1H3,(H,24,26)
  • InChiKey: NYEVDPSLRFLBRX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 Starlite/ChEMBL References
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0609 0.0601
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0623 0.0614
Toxoplasma gondii hypothetical protein 0.0026 0.0205 0.0746
Schistosoma mansoni neuropeptide receptor 0.006 0.0609 0.0608
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0011
Echinococcus granulosus neuropeptide s receptor 0.0615 0.7267 0.7354
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0248 0.0932
Brugia malayi hypothetical protein 0.0011 0.0025 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0144 0.0171
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.0609 0.0609
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.0609 0.0609
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.0609 0.0721
Schistosoma mansoni hypothetical protein 0.006 0.0609 0.0608
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0087 0.0078
Onchocerca volvulus 0.006 0.0609 0.1064
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.0609 0.0601
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0164 0.0591
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.0609 0.0721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0144 0.0136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0002
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.0609 0.0608
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.2061 0.2437
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0661 0.0781
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0144 0.0237
Echinococcus multilocularis sex peptide receptor 0.006 0.0609 0.0601
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.0609 0.0721
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.08 0.0792
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0164 0.0591
Echinococcus granulosus survival motor neuron protein 1 0.0715 0.8457 0.856
Schistosoma mansoni histamine h1 receptor 0.006 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0661 0.0652
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0487 0.0479
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0248 0.0908
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0144 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0248 0.0908
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0588 0.0587
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0025 0.0016
Leishmania major guanosine monophosphate reductase 0.0228 0.263 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0144 0.0136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0623 0.0614
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0144 0.0137
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0164 0.0156
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Onchocerca volvulus 0.0146 0.1639 0.2896
Brugia malayi Dopamine receptor 0.006 0.0609 0.0721
Loa Loa (eye worm) hypothetical protein 0.0715 0.8457 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0164 0.0607
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0164 0.0591
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.2061 0.2437
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0413 0.1581
Echinococcus multilocularis g protein coupled receptor 0.006 0.0609 0.0601
Schistosoma mansoni opsin-like receptor 0.006 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Mycobacterium tuberculosis Probable oxidoreductase 0.0217 0.2492 0.7615
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0427 0.1595
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0087 0.0079
Brugia malayi Melatonin receptor type 1A 0.006 0.0609 0.0721
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0144 0.0171
Schistosoma mansoni Smad4 0.0016 0.0087 0.0078
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.0609 0.0601
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0609 0.0608
Plasmodium falciparum thioredoxin reductase 0.0086 0.0918 0.3556
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.0609 0.0608
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0609 0.0608
Echinococcus multilocularis neuropeptide receptor 0.006 0.0609 0.0601
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0386 0.0405
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0487 0.0485
Onchocerca volvulus 0.006 0.0609 0.1064
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.0609 0.0608
Echinococcus multilocularis g protein coupled receptor 0.006 0.0609 0.0601
Loa Loa (eye worm) glutathione reductase 0.0086 0.0918 0.1085
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Onchocerca volvulus 0.006 0.0609 0.1064
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0609 0.0601
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0427 0.0424
Echinococcus granulosus cpg binding protein 0.0032 0.0275 0.0269
Brugia malayi follicle stimulating hormone receptor 0.0297 0.3457 0.4088
Onchocerca volvulus 0.006 0.0609 0.1064
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0609 0.0601
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0353 0.0348
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0228 0.263 0.311
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0025 0.0016
Loa Loa (eye worm) beta-lactamase 0.0043 0.0413 0.0489
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Schistosoma mansoni nuclear receptor 0.001 0.0011 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0248 0.0932
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0609 0.0608
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0609 0.0601
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.0609 0.0601
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0924 0.0916
Loa Loa (eye worm) hypothetical protein 0.0043 0.0413 0.0489
Brugia malayi MH2 domain containing protein 0.0016 0.0087 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0144 0.0171
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0413 0.0814
Brugia malayi Pre-SET motif family protein 0.0061 0.0623 0.0736
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0248 0.0337
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0609 0.0601
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.003 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0661 0.066
Brugia malayi neuropeptide F receptor 0.006 0.0609 0.0721
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0645 0.2425
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Onchocerca volvulus 0.0043 0.0413 0.0715
Brugia malayi G-protein coupled receptor 0.006 0.0609 0.0721
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0144 0.0137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0144 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0144 0.0171
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0503 0.0501
Echinococcus granulosus neuropeptide receptor 0.006 0.0609 0.0609
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0248 0.0908
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0144 0.0136
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.0609 0.0601
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Plasmodium vivax hypothetical protein, conserved 0.003 0.0256 0.0964
Echinococcus granulosus microtubule associated protein 2 0.0833 0.9878 1
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0413 0.1541
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.9878 0.9878
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0609 0.0609
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0205 0.0638
Onchocerca volvulus 0.006 0.0609 0.1064
Brugia malayi hypothetical protein 0.001 0.0011 0.0013
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0011 0.0002
Brugia malayi Dopamine receptor protein 2 0.006 0.0609 0.0721
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0413 0.1541
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0228 0.263 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0413 0.041
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.08 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0171
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0144 0.0137
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0248 0.0908
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0144 0.0171
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0144 0.0137
Schistosoma mansoni hypothetical protein 0.0335 0.3909 0.3951
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0248 0.0932
Brugia malayi RNA binding protein 0.0064 0.0661 0.0781
Brugia malayi GMP reductase 0.0098 0.1072 0.1268
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0228 0.263 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0144 0.0171
Echinococcus multilocularis muscleblind protein 1 0.0176 0.2006 0.1999
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0144 0.0137
Brugia malayi PHD-finger family protein 0.0012 0.0032 0.0038
Brugia malayi Thioredoxin reductase 0.0086 0.0918 0.1085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.2061 0.2079
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0087 0.0103
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0609 0.0601
Leishmania major inosine-5-monophosphate dehydrogenase 0.0228 0.263 1
Onchocerca volvulus 0.006 0.0609 0.1064
Echinococcus multilocularis muscleblind protein 0.0176 0.2006 0.1999
Onchocerca volvulus 0.0043 0.0413 0.0715
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.0609 0.0721
Schistosoma mansoni biogenic amine receptor 0.006 0.0609 0.0608
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0609 0.0609
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0609 0.0601
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0254 0.03
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0248 0.0293
Giardia lamblia PHD finger protein 15 0.003 0.0256 0.2693
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.08 0.3096
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0413 0.0455
Treponema pallidum NADH oxidase 0.003 0.0248 0.1308
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0398 0.0394
Toxoplasma gondii thioredoxin reductase 0.0086 0.0918 0.3465
Brugia malayi Cytochrome P450 family protein 0.0046 0.044 0.052
Trypanosoma cruzi GMP reductase 0.0228 0.263 1
Brugia malayi Pre-SET motif family protein 0.0421 0.4936 0.5837
Mycobacterium tuberculosis Conserved protein 0.0043 0.0413 0.0814
Loa Loa (eye worm) hypothetical protein 0.0076 0.08 0.0946
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0686 0.0685
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0144 0.0137
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0503 0.1884
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.0609 0.1064
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0144 0.0171
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0128 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0609 0.0608
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0609 0.0601
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0248 0.0908
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.0609 0.0601
Onchocerca volvulus 0.006 0.0609 0.1064
Echinococcus granulosus orexin receptor type 2 0.006 0.0609 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0144 0.0171
Schistosoma mansoni opsin-like receptor 0.006 0.0609 0.0608
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.1083 0.1075
Brugia malayi putative neuropeptide receptor 0.006 0.0609 0.0721
Trypanosoma brucei protein kinase, putative 0.0051 0.0503 0.1884
Schistosoma mansoni ap endonuclease 0.0023 0.0164 0.0157
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0324 0.0315
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0248 0.0932
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0609 0.0721
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0623 0.0622
Schistosoma mansoni nuclear receptor 0.001 0.0011 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0144 0.0136
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0503 0.1884
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0011 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.044 0.052
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0228 0.263 0.2656
Toxoplasma gondii exonuclease III APE 0.0023 0.0164 0.0591
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0248 0.0242
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0413 0.0489
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0386 0.0382
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0031 0.0022
Loa Loa (eye worm) Smad1 0.0016 0.0087 0.0103
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus multilocularis somatostatin receptor 0.006 0.0609 0.0601
Echinococcus multilocularis g protein coupled receptor 0.006 0.0609 0.0601
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0144 0.0137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0609 0.0608
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0427 0.1595
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0033 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0144 0.0171
Onchocerca volvulus 0.006 0.0609 0.1064
Brugia malayi jmjC domain containing protein 0.001 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Brugia malayi hypothetical protein 0.001 0.0011 0.0013
Schistosoma mansoni smad1 5 8 and 0.0016 0.0087 0.0078
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0248 0.0908
Brugia malayi jmjC domain containing protein 0.001 0.001 0.0011
Brugia malayi MH2 domain containing protein 0.0016 0.0087 0.0103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0144 0.0137
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0918 0.2464
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0413 0.0455
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0011 0.0013
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.0609 0.0601
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0223 0.2562 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0144 0.0136
Loa Loa (eye worm) TYRA-2 protein 0.006 0.0609 0.0721
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0413 0.0814
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0609 0.0721
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0427 0.0424
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0087 0.0103
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0427 0.0423
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.08 1
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0609 0.0609
Echinococcus granulosus tar DNA binding protein 0.0064 0.0661 0.066
Echinococcus multilocularis Smad4 0.0016 0.0087 0.0078
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.003
Echinococcus multilocularis peregrin 0.0034 0.0297 0.0288
Schistosoma mansoni adenoreceptor 0.006 0.0609 0.0608
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.0609 0.0601
Onchocerca volvulus 0.0061 0.0623 0.1088
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.0609 0.0609
Echinococcus multilocularis serotonin receptor 0.006 0.0609 0.0601
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0609 0.0609
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0503 0.0495
Echinococcus granulosus G protein coupled receptor 139 0.006 0.0609 0.0609
Entamoeba histolytica hypothetical protein 0.0036 0.0324 0.6055
Brugia malayi AKH receptor 0.006 0.0609 0.0721
Brugia malayi ORL1-like opioid receptor 0.006 0.0609 0.0721
Brugia malayi beta-lactamase 0.0043 0.0413 0.0489
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0011 0.0006
Entamoeba histolytica hypothetical protein 0.0036 0.0324 0.6055
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.0609 0.0721
Loa Loa (eye worm) RNA binding protein 0.0064 0.0661 0.0781
Echinococcus granulosus smad 0.0016 0.0087 0.0079
Schistosoma mansoni hypothetical protein 0.006 0.0609 0.0608
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.2061 0.2054
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0248 0.2453
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0609 0.0608
Brugia malayi larval opioid receptor 0.006 0.0609 0.0721
Plasmodium falciparum thioredoxin reductase 0.003 0.0248 0.0932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0248 0.0908
Brugia malayi Dopamine receptor protein 1 0.006 0.0609 0.0721
Loa Loa (eye worm) hypothetical protein 0.0052 0.0515 0.0609
Trypanosoma brucei trypanothione reductase 0.0086 0.0918 0.3465
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0144 0.0237
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0248 0.0152
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0025 0.0017
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0228 0.263 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.08 0.3016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0609 0.0601
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus granulosus neuropeptide receptor A26 0.0615 0.7267 0.7354
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0124 0.1383 0.4857
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0427 0.1595
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.0609 0.0609
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.2749 0.3251
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0609 0.0601
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0609 0.0608
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.001 0.0001
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0503 0.062
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.003
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.9878 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0487 0.1056
Brugia malayi ecdysteroid receptor 0.0021 0.0144 0.0171
Echinococcus granulosus jumonji domain containing 1A 0.001 0.001 0.0001
Echinococcus granulosus phd:f box containing protein 0.001 0.001 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0609 0.0608
Plasmodium vivax glutathione reductase, putative 0.0086 0.0918 0.3556
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0248 0.0241
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Trypanosoma cruzi GMP reductase 0.0228 0.263 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0223 0.2562 0.9727
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0098 0.1072 0.1268
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0171
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.001 0.0001
Schistosoma mansoni hypothetical protein 0.006 0.0609 0.0608
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0427 0.0419
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0144 0.0136
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0011 0.0002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0153 0.0181
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0256 0.0939
Brugia malayi TAR-binding protein 0.0064 0.0661 0.0781
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0609 0.0601
Echinococcus granulosus hypothetical protein 0.006 0.0609 0.0609
Onchocerca volvulus 0.006 0.0609 0.1064
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0164 0.0195
Mycobacterium ulcerans hypothetical protein 0.0043 0.0413 0.1009
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0427 0.0419
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0144 0.0171
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0918 0.3465
Loa Loa (eye worm) hypothetical protein 0.0043 0.0413 0.0489
Brugia malayi MH1 domain containing protein 0.0016 0.0087 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.0609 0.0721
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0302
Brugia malayi PHD-finger family protein 0.003 0.0256 0.0302
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0031 0.0036
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0011 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0413 0.0859
Onchocerca volvulus 0.006 0.0609 0.1064
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0011 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0413 0.0409
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0223 0.2562 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0324 0.0318
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0413 0.1009
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus multilocularis fmrfamide receptor 0.006 0.0609 0.0601
Brugia malayi jmjC domain containing protein 0.0099 0.1083 0.128
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0148 0.0175
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.08 0.3096
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0623 0.0621
Schistosoma mansoni amine GPCR 0.006 0.0609 0.0608
Onchocerca volvulus Putative GMP reductase 0.0098 0.1072 0.1887
Schistosoma mansoni cpg binding protein 0.003 0.0254 0.0248
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0427 0.1595
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0011 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0144 0.0137
Schistosoma mansoni myosin xvIII 0.006 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0427 0.0481
Mycobacterium tuberculosis Conserved protein 0.0043 0.0413 0.0814
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0503 0.1884
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0413 0.0489
Brugia malayi conserved hypotetical protein 0.001 0.0011 0.0013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0144 0.0137
Leishmania major hypothetical protein, conserved 0.0043 0.0413 0.1541
Mycobacterium ulcerans beta-lactamase 0.0043 0.0413 0.1009
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0248 0.0908
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0609 0.0608
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0256 0.0249
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0256 0.0939
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.0609 0.0721
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.0609 0.0601
Onchocerca volvulus Alhambra homolog 0.003 0.0256 0.0435
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.0609 0.0608
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0609 0.0601
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0248 0.0908
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0011 0.0003
Mycobacterium ulcerans lipase LipD 0.0043 0.0413 0.1009
Entamoeba histolytica hypothetical protein 0.0036 0.0324 0.6055
Echinococcus multilocularis allatostatin A receptor 0.006 0.0609 0.0601
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0248 0.0908
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.0609 0.0601
Brugia malayi ecdysone receptor 0.001 0.0011 0.0013
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0087 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0144 0.0171
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.0609 0.0721
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0248 0.0337
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0144 0.0171
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0609 0.0609
Onchocerca volvulus 0.006 0.0609 0.1064
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0171
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0256 0.0247
Schistosoma mansoni hypothetical protein 0.0335 0.3909 0.3951
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0205 0.0765
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0171
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0248 0.0908
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.001 0.0001
Echinococcus granulosus g-protein coupled receptor 0.006 0.0609 0.0609
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0144 0.0171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0609 0.0608
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.0609 0.0608
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0248 0.0908
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0248 0.0908
Echinococcus multilocularis neuropeptide receptor 0.006 0.0609 0.0601
Loa Loa (eye worm) GMP reductase 0.0098 0.1072 0.1268
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0661 0.066
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.0609 0.0601
Entamoeba histolytica hypothetical protein 0.0036 0.0324 0.6055
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0413 0.0814
Echinococcus granulosus peregrin 0.0034 0.0297 0.0292
Echinococcus multilocularis neuropeptide receptor A26 0.0615 0.7267 0.7264
Mycobacterium tuberculosis Probable dehydrogenase 0.0195 0.2231 0.6761
Schistosoma mansoni hypothetical protein 0.003 0.0256 0.0249
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3221 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0386 0.1473
Schistosoma mansoni ap endonuclease 0.0023 0.0164 0.0157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0609 0.0601
Brugia malayi nuclear receptor RXR 0.0011 0.0025 0.003
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.0609 0.0609
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0345 0.6851
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0025 0.003
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0205 0.0765
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0609 0.0609
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0144 0.0137
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0386 0.1435
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0623 0.2339
Schistosoma mansoni hypothetical protein 0.001 0.0011 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.2061 0.2054
Schistosoma mansoni biogenic amine receptor 0.006 0.0609 0.0608
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0098 0.1072 0.1268
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0609 0.0608
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0248 0.0908
Brugia malayi CXXC zinc finger family protein 0.003 0.0254 0.03
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0144 0.0171
Loa Loa (eye worm) hypothetical protein 0.0045 0.0427 0.0505
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0427 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0924 0.0927
Mycobacterium tuberculosis Conserved protein 0.0043 0.0413 0.0814
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0195 0.2231 0.6761
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Plasmodium falciparum glutathione reductase 0.003 0.0248 0.0932
Schistosoma mansoni amine GPCR 0.006 0.0609 0.0608
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0503 0.062
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.0609 0.0609
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0609 0.0609
Echinococcus granulosus geminin 0.0335 0.3909 0.3952
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.003
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0661 0.0781
Schistosoma mansoni cpg binding protein 0.0032 0.0275 0.0268
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0144 0.0137
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0248 0.0337
Onchocerca volvulus 0.006 0.0609 0.1064
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0033 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0176 0.2006 0.2372
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.157 0.1857
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0171
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.0609 0.1064
Brugia malayi nuclear receptor NHR-67 0.001 0.0011 0.0013
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.0609 0.0721
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0144 0.0171
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus granulosus serotonin receptor 0.006 0.0609 0.0609
Brugia malayi Muscleblind-like protein 0.0176 0.2006 0.2372
Schistosoma mansoni hypothetical protein 0.0146 0.1639 0.1651
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.001 0.0011
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0164 0.0195
Loa Loa (eye worm) hypothetical protein 0.0043 0.0413 0.0489
Echinococcus granulosus Smad4 0.0016 0.0087 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0661 0.0781
Schistosoma mansoni amine GPCR 0.006 0.0609 0.0608
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0144 0.0137
Brugia malayi Smad1 0.0016 0.0087 0.0103
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0427 0.0419
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0217 0.2492 0.7615
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0011 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0353 0.0348
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1523 0.1534
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0609 0.0609
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0104 0.1139 0.3955
Onchocerca volvulus 0.0021 0.0144 0.0237
Onchocerca volvulus 0.0479 0.5632 1
Schistosoma mansoni biogenic amine receptor 0.006 0.0609 0.0608
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0386 0.1435
Echinococcus multilocularis neuropeptide s receptor 0.0615 0.7267 0.7264
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0503 0.1884
Echinococcus multilocularis orexin receptor type 2 0.006 0.0609 0.0601
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0228 0.263 1
Leishmania major trypanothione reductase 0.0086 0.0918 0.3465
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0413 0.0405
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0609 0.0609
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0503 0.0495
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0217 0.2492 0.7615
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.1083 0.1088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.2061 0.2078
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.0609 0.0601
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0609 0.0609
Onchocerca volvulus Huntingtin homolog 0.0127 0.1419 0.2505
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0623 0.0621
Echinococcus multilocularis phd:f box containing protein 0.001 0.001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0386 0.0405
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.0609 0.0609
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.08 0.0801
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.2061 0.2078
Brugia malayi Serotonin receptor 0.006 0.0609 0.0721
Echinococcus multilocularis geminin 0.0335 0.3909 0.3904
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0398 0.039
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0011 0.0003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0413 0.0489
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0427 0.7762
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.001 0.0001
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0011 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0413 0.0489
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.0609 0.0601
Plasmodium falciparum phd finger protein, putative 0.003 0.0256 0.0964
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0503 0.05
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.0609 0.0601
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0661 0.066
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.08 0.3016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0025 0.0017
Onchocerca volvulus 0.006 0.0609 0.1064
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0144 0.0171
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.001 0.0011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0413 0.0814
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.0609 0.0608
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0164 0.0591
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0144 0.0171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0248 0.0908
Schistosoma mansoni survival motor neuron protein 0.0146 0.1639 0.1651
Loa Loa (eye worm) hypothetical protein 0.0127 0.1419 0.1678
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0248 0.0152
Brugia malayi AF-10 protein 0.001 0.0011 0.0013
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.0609 0.0721
Brugia malayi hypothetical protein 0.0036 0.0324 0.0383
Brugia malayi Bromodomain containing protein 0.0034 0.0297 0.0351
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0195 0.2231 0.8355
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0503 0.1884
Loa Loa (eye worm) acetyltransferase 0.014 0.157 0.1857
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0413 0.0455
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0503 0.1884
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0164 0.0607
Echinococcus granulosus allatostatin A receptor 0.006 0.0609 0.0609
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0643 0.076
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0031 0.0022
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0087 0.0078
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0144 0.0137
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0146 0.1639 0.1938
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Onchocerca volvulus 0.006 0.0609 0.1064
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0104 0.1139 0.3854
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0025 0.003
Onchocerca volvulus 0.006 0.0609 0.1064
Mycobacterium tuberculosis Probable reductase 0.0195 0.2231 0.6761
Onchocerca volvulus 0.003 0.0254 0.0432
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0228 0.263 0.2655
Echinococcus multilocularis cpg binding protein 0.0032 0.0275 0.0266
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0144 0.0137
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0332 0.0324
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0228 0.263 1
Schistosoma mansoni amine GPCR 0.006 0.0609 0.0608
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0427 0.0423
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.0003
Onchocerca volvulus 0.006 0.0609 0.1064
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0256 0.0302
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.08 0.2577
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0503 0.062
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.157 0.1563
Echinococcus granulosus g protein coupled receptor 0.006 0.0609 0.0609
Brugia malayi glutathione reductase 0.0086 0.0918 0.1085
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Brugia malayi sulfakinin receptor protein 0.006 0.0609 0.0721
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0413 0.0814
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.2061 0.2079
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0011 0.0002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0195 0.2231 0.6761
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0248 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0144 0.0171
Brugia malayi beta-lactamase family protein 0.0043 0.0413 0.0489
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0609 0.0601
Brugia malayi jmjC domain containing protein 0.0038 0.0353 0.0417
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0609 0.0609
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0413 0.1541
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.003 0.0022
Loa Loa (eye worm) IMP dehydrogenase 1 0.0228 0.263 0.311
Plasmodium falciparum glutathione reductase 0.0086 0.0918 0.3556
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0609 0.0608
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.0609 0.0609
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0256 0.025
Toxoplasma gondii ABC1 family protein 0.0043 0.0413 0.1541
Brugia malayi MH1 domain containing protein 0.0016 0.0087 0.0103
Echinococcus granulosus g protein coupled receptor 0.006 0.0609 0.0609
Brugia malayi beta-lactamase family protein 0.0043 0.0413 0.0489
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0013
Brugia malayi GnHR receptor homolog 0.006 0.0609 0.0721
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0144 0.0137
Brugia malayi neuropeptide F receptor 0.006 0.0609 0.0721
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0353 0.0417
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0011 0.0006
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.0609 0.0608
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0011 0.0006
Brugia malayi hypothetical protein 0.0715 0.8457 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0144 0.0237
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0918 0.3556
Brugia malayi Serotonin receptor 0.006 0.0609 0.0721
Brugia malayi nuclear receptor RXR 0.001 0.0011 0.0013
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0353 0.0349
Echinococcus multilocularis serotonin receptor 0.006 0.0609 0.0601
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0345 0.1312
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0609 0.0601
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0609 0.0608
Brugia malayi nuclear hormone receptor 0.0021 0.0144 0.0171
Echinococcus granulosus g protein coupled receptor 0.006 0.0609 0.0609
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0345 0.5318
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0413 0.1009
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0228 0.263 0.2623
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0144 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0661 0.066
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.0003
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0918 0.1085
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.0609 0.0721
Schistosoma mansoni hypothetical protein 0.006 0.0609 0.0608
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.0609 0.0609
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0144 0.0171
Echinococcus granulosus muscleblind protein 0.0176 0.2006 0.2024
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0503 0.1884
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0503 0.062
Echinococcus granulosus fmrfamide receptor 0.006 0.0609 0.0609
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0413 0.0814
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0609 0.0721
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0248 0.0239
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.003
Schistosoma mansoni neuropeptide receptor 0.006 0.0609 0.0608
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0248 0.0337
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0413 0.0455
Brugia malayi MAP kinase sur-1 0.0051 0.0503 0.0595
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0503 0.1884
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.157 0.1581
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0011 0.0013
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0838 0.0839
Brugia malayi jmjC domain containing protein 0.001 0.001 0.0011
Schistosoma mansoni zinc finger protein 0.001 0.0011 0.0002
Brugia malayi RE15519p 0.006 0.0609 0.0721
Trichomonas vaginalis set domain proteins, putative 0.0479 0.5632 1
Brugia malayi tailless protein 0.001 0.0011 0.0013
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.08 0.2577
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0609 0.0601
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0609 0.0609
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0413 0.0814
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0144 0.0136
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0623 0.0621
Schistosoma mansoni smad 0.0016 0.0087 0.0078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0171
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0248 0.0908
Schistosoma mansoni amine GPCR 0.006 0.0609 0.0608
Brugia malayi jmjC domain containing protein 0.001 0.001 0.0011
Echinococcus granulosus neuropeptide receptor 0.006 0.0609 0.0609
Schistosoma mansoni opsin-like receptor 0.006 0.0609 0.0608
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0248 0.0337
Brugia malayi hypothetical protein 0.0011 0.0025 0.003
Loa Loa (eye worm) hypothetical protein 0.0127 0.1419 0.1678
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0217 0.2492 0.9431
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0248 0.0908
Schistosoma mansoni smad1 5 8 and 0.0016 0.0087 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.2749 0.3251
Brugia malayi G protein-coupled receptor 0.006 0.0609 0.0721
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.0609 0.0721
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0487 0.1056
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Loa Loa (eye worm) hypothetical protein 0.0061 0.0623 0.0736
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0144 0.0137
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.0609 0.0608
Schistosoma mansoni neuropeptide receptor 0.006 0.0609 0.0608
Echinococcus multilocularis survival motor neuron protein 1 0.0715 0.8457 0.8455
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0248 0.0908
Schistosoma mansoni cpg binding protein 0.0032 0.0275 0.0268
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0171
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus multilocularis smad 0.0016 0.0087 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0661 0.066
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0503 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0427 0.0481
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0297 0.3457 0.4088
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.0609 0.0609
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.08 0.2453
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0144 0.0171
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0228 0.263 0.8066
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0609 0.0609
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.08 0.0802
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.4936 0.5837
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0013
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0427 0.0505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0144 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0609 0.0609
Brugia malayi MH2 domain containing protein 0.0238 0.2749 0.3251
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Onchocerca volvulus Huntingtin homolog 0.0127 0.1419 0.2505
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0487 0.1164
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0011 0.0013
Brugia malayi nuclear receptor NHR-88 0.0021 0.0144 0.0171
Loa Loa (eye worm) DR-78 0.001 0.0011 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0413 0.0455
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0228 0.263 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0248 0.0908
Echinococcus multilocularis fmrfamide receptor 0.006 0.0609 0.0601
Echinococcus granulosus somatostatin receptor 0.006 0.0609 0.0609
Schistosoma mansoni hypothetical protein 0.0036 0.0324 0.0318
Plasmodium vivax SET domain protein, putative 0.0061 0.0623 0.2401
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.0002
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0503 0.0501
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0427 0.0424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.2061 0.2078
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0609 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0144 0.0171
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0413 0.0409
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Echinococcus multilocularis g-protein coupled receptor 0.006 0.0609 0.0601
Brugia malayi hypothetical protein 0.0127 0.1419 0.1678
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0144 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0623 0.0621
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.08 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0609 0.0609
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0087 0.0079
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.0609 0.0608
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.08 0.2577
Trypanosoma brucei GMP reductase 0.0228 0.263 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0087 0.0078
Echinococcus granulosus sex peptide receptor 0.006 0.0609 0.0609
Trichomonas vaginalis esterase, putative 0.0043 0.0413 0.0455
Schistosoma mansoni coup transcription factor 0.0021 0.0144 0.0137
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0609 0.0721
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Brugia malayi G-protein coupled receptor 0.006 0.0609 0.0721
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0228 0.263 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.2006 0.2372
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.001 0.0011
Toxoplasma gondii IMP dehydrogenas 0.0228 0.263 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0144 0.0171
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0503 0.0595
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0124 0.1383 0.3986
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0144 0.0136
Schistosoma mansoni neuropeptide receptor 0.006 0.0609 0.0608
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0427 0.0481
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0011 0.0002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0195 0.2231 0.6761
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0721
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0195 0.2231 0.6761
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0609 0.0609
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0144 0.0136
Brugia malayi Probable ClpP-like protease 0.0076 0.08 0.0946
Onchocerca volvulus 0.006 0.0609 0.1064
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0025 0.003
Brugia malayi steroid hormone receptor 0.0021 0.0144 0.0171
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0164 0.0158
Loa Loa (eye worm) hypothetical protein 0.0043 0.0413 0.0489
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0153 0.0181
Mycobacterium leprae Probable lipase LipE 0.0043 0.0413 0.0859
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0609 0.0608
Onchocerca volvulus 0.0043 0.0413 0.0715
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.0609 0.0721
Brugia malayi hypothetical protein 0.006 0.0609 0.0721
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0609 0.0601

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 105 nM Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5 mins prior to substrate addition by fluorescence assay ChEMBL. 23668331
IC50 (binding) = 118 nM Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5 mins prior to substrate addition by fluorescence assay in presence of BSA ChEMBL. 23668331
IC50 (binding) > 5 uM Inhibition of human IMPDH2 ChEMBL. 23668331

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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