TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 540.745 | Formula: C23H12Cl3N7O3
H donors: 3 H acceptors: 5 LogP: 5.86 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1c(Nc2ccc(cc2Nc2ccc(c3c2c(=O)[nH]cn3)[N+](=O)[O-])C)c(Cl)c(c(c1Cl)C#N)Cl
InChi: 1S/C23H12Cl3N7O3/c1-10-2-3-13(32-21-12(8-28)18(24)11(7-27)19(25)20(21)26)15(6-10)31-14-4-5-16(33(35)36)22-17(14)23(34)30-9-29-22/h2-6,9,31-32H,1H3,(H,29,30,34)
InChiKey: MCPWYBAQQIMSLO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Oxysterol-binding protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0027	0.0174	0.09
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0027	0.0174	0.000000090368
Echinococcus granulosus	Rho GTPase activating protein 24	0.0027	0.0174	0.0151
Trypanosoma cruzi	NIMA-related kinase, putative	0.0031	0.0206	1
Echinococcus multilocularis	axis inhibition protein axin	0.0165	0.1267	0.1247
Schistosoma mansoni	hypothetical protein	0.0034	0.0228	0.0228
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0027	0.0174	0.0151
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0228	0.0481
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0027	0.0174	0.0151
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0347	0.2704	0.2677
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Schistosoma mansoni	growth factor receptor-bound protein	0.0027	0.0174	0.0174
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Brugia malayi	hypothetical protein	0.0165	0.1267	0.3095
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.02	0.02
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.1835	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0031	0.0206	1
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Trypanosoma cruzi	NIMA-related kinase, putative	0.0031	0.0206	1
Loa Loa (eye worm)	rho-GTPase-activating	0.0027	0.0174	0.0137
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0347	0.2704	0.2687
Trichomonas vaginalis	protein transport protein sec7, putative	0.0027	0.0174	0.09
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0322	0.0322
Brugia malayi	probable spectrin beta chain	0.0027	0.0174	0.0346
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Schistosoma mansoni	serine/threonine protein kinase	0.0512	0.4013	0.4013
Echinococcus granulosus	calcium dependent secretion activator 1	0.0027	0.0174	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Entamoeba histolytica	hypothetical protein	0.0165	0.1267	1
Schistosoma mansoni	serine/threonine protein kinase	0.1268	1	1
Brugia malayi	hypothetical protein	0.0165	0.1267	0.3095
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.02	0.0176
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0186	0.0374
Echinococcus multilocularis	myotubularin protein 13	0.0027	0.0174	0.0151
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0165	0.1267	0.1247
Echinococcus multilocularis	Pleckstrin y	0.0027	0.0174	0.0151
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0024	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Schistosoma mansoni	goodpasture antigen-binding protein	0.0027	0.0174	0.0174
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0322	0.0299
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0186	0.0162
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0083	0.006
Schistosoma mansoni	hypothetical protein	0.0016	0.0083	0.0083
Schistosoma mansoni	hypothetical protein	0.0408	0.319	0.319
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Echinococcus granulosus	axis inhibition protein axin	0.0165	0.1267	0.1247
Echinococcus granulosus	DCC interacting protein 13 beta	0.0027	0.0174	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0353	0.0316
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Loa Loa (eye worm)	hypothetical protein	0.005	0.0353	0.0316
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0027	0.0174	0.0174
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0027	0.0174	0.0151
Echinococcus granulosus	GPCR family 2	0.0016	0.0083	0.006
Echinococcus multilocularis	oxysterol binding protein 3	0.0027	0.0174	0.0151
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0027	0.0174	0.09
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1268	1	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0186	0.0149
Brugia malayi	Pleckstrin Homology Domain	0.0027	0.0174	0.0346
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus granulosus	Pleckstrin y	0.0027	0.0174	0.0151
Schistosoma mansoni	hypothetical protein	0.0016	0.0083	0.0083
Echinococcus multilocularis	pdz domain containing protein	0.0027	0.0174	0.0151
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0083	0.006
Entamoeba histolytica	hypothetical protein	0.0165	0.1267	1
Brugia malayi	TBC domain containing protein	0.0027	0.0174	0.0346
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0027	0.0174	0.0174
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0353	0.0794
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	alpha chimerin, putative	0.0027	0.0174	0.09
Echinococcus granulosus	Pleckstrin y	0.0027	0.0174	0.0151
Onchocerca volvulus		0.0029	0.0186	0.0068
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0322	0.0299
Brugia malayi	regulator of G-protein signaling egl-10	0.0165	0.1267	0.3095
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0031	0.0206	0.0169
Echinococcus granulosus	oxysterol binding protein 3	0.0027	0.0174	0.0151
Echinococcus granulosus	Regulator of G protein signaling 20	0.0165	0.1267	0.1247
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0512	0.4013	0.399
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0397	1
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus granulosus	beta 1 syntrophin	0.0027	0.0174	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus granulosus	cpg binding protein	0.003	0.0199	0.0175
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0027	0.0174	0.0174
Plasmodium vivax	SET domain protein, putative	0.003	0.02	0.8004
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0083	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus multilocularis	Oxysterol binding protein 11	0.0027	0.0174	0.0151
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0083	0.006
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0027	0.0174	0.0151
Schistosoma mansoni	cpg binding protein	0.0029	0.0186	0.0186
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0027	0.0174	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Echinococcus multilocularis	rac serine:threonine kinase	0.0031	0.0206	0.0182
Echinococcus granulosus	serine/threonine protein kinase	0.0031	0.0206	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus multilocularis	cytohesin 1	0.0027	0.0174	0.0151
Schistosoma mansoni	axis inhibition protein axin	0.0165	0.1267	0.1267
Schistosoma mansoni	z-protein (S1r protein)	0.0165	0.1267	0.1267
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Brugia malayi	Cadps2 protein	0.0027	0.0174	0.0346
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0165	0.1267	0.1267
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1268	1	1
Loa Loa (eye worm)	PH domain-containing protein	0.0027	0.0174	0.0137
Trypanosoma brucei	protein kinase, putative	0.0031	0.0206	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0165	0.1267	0.1247
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus multilocularis	cpg binding protein	0.003	0.0199	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.02	0.113
Echinococcus granulosus	expressed protein	0.0165	0.1267	0.1247
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.1608	0.1576
Entamoeba histolytica	p21-activated kinase	0.0031	0.0206	0.0288
Trichomonas vaginalis	centaurin/arf, putative	0.0027	0.0174	0.09
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0083	0.0117
Schistosoma mansoni	rho gtpase activating protein	0.0027	0.0174	0.0174
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	Syntrophin-1	0.0027	0.0174	0.0346
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0031	0.0206	1
Onchocerca volvulus		0.003	0.02	0.0152
Loa Loa (eye worm)	oxysterol binding protein	0.0027	0.0174	0.0137
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0165	0.1267	0.1247
Schistosoma mansoni	dynamin	0.0027	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus granulosus	pdz domain containing protein	0.0027	0.0174	0.0151
Schistosoma mansoni	centaurin alpha	0.0027	0.0174	0.0174
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0031	0.0206	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0165	0.1267	0.1247
Schistosoma mansoni	hypothetical protein	0.0016	0.0083	0.0083
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0031	0.0206	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0322	0.0299
Schistosoma mansoni	serine/threonine-protein kinase	0.0031	0.0206	0.0206
Brugia malayi	Pre-SET motif family protein	0.003	0.02	0.0409
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0322	0.0285
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0449	0.0449
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0512	0.4013	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0347	0.2704	0.2687
Loa Loa (eye worm)	cytohesin 3	0.0027	0.0174	0.0137
Brugia malayi	MAX-1A	0.0027	0.0174	0.0346
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Echinococcus multilocularis	dynamin 1	0.0027	0.0174	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0322	0.0717
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0027	0.0174	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0031	0.0206	1
Brugia malayi	Pre-SET motif family protein	0.0208	0.1608	0.3951
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0027	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.02	0.0176
Echinococcus multilocularis	actin binding protein anillin	0.0027	0.0174	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus granulosus	regulator of G protein signaling 7	0.0165	0.1267	0.1247
Loa Loa (eye worm)	PXA domain-containing protein	0.0165	0.1267	0.1234
Echinococcus multilocularis	expressed protein	0.0165	0.1267	0.1247
Echinococcus multilocularis	Pleckstrin y	0.0027	0.0174	0.0151
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0031	0.0206	1
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0031	0.0206	1
Echinococcus multilocularis	oxysterol binding protein 9	0.0027	0.0174	0.0151
Brugia malayi	Plekhf2 protein	0.0027	0.0174	0.0346
Leishmania major	protein kinase, putative	0.0031	0.0206	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.02	0.0163
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0027	0.0174	0.0151
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0027	0.0174	0.0151
Leishmania major	serine/threonine-protein kinase a, putative	0.0031	0.0206	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.02	0.02
Echinococcus multilocularis	muscleblind protein	0.0155	0.1185	0.1164
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0031	0.0206	1
Echinococcus multilocularis	beta 1 syntrophin	0.0027	0.0174	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Trichomonas vaginalis	centaurin/arf, putative	0.0027	0.0174	0.09
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0027	0.0174	0.0346
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0027	0.0174	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	Uncoordinated protein 104	0.0027	0.0174	0.0346
Schistosoma mansoni	myotubularin-related protein	0.0027	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	centaurin beta, putative	0.0027	0.0174	0.09
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0031	0.0206	1
Schistosoma mansoni	cpg binding protein	0.003	0.0199	0.0199
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0031	0.0206	1
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1185	0.1152
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0027	0.0174	0.0151
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0031	0.0206	1
Echinococcus granulosus	GRB2 associated binding protein 3	0.0027	0.0174	0.0151
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0027	0.0174	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0165	0.1267	0.1267
Schistosoma mansoni	goodpasture antigen-binding protein	0.0027	0.0174	0.0174
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0083	0.006
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0027	0.0174	0.0151
Schistosoma mansoni	dynamin	0.0027	0.0174	0.0174
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.02	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1185	0.1152
Echinococcus granulosus	regulator of G protein signaling 3	0.0165	0.1267	0.1247
Echinococcus multilocularis	muscleblind protein 1	0.0155	0.1185	0.1164
Schistosoma mansoni	zinc finger protein	0.0027	0.0174	0.0174
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0027	0.0174	0.09
Brugia malayi	Dynamin	0.0027	0.0174	0.0346
Schistosoma mansoni	oxysterol-binding protein 1	0.0027	0.0174	0.0174
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	Muscleblind-like protein	0.0155	0.1185	0.2889
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0228	0.0191
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0165	0.1267	0.3095
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Echinococcus granulosus	oxysterol binding protein 9	0.0027	0.0174	0.0151
Echinococcus multilocularis	axis inhibition protein axin	0.0165	0.1267	0.1247
Brugia malayi	Cytohesin 3	0.0027	0.0174	0.0346
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0165	0.1267	0.1247
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	kinesin light chain, putative	0.0027	0.0174	0.09
Schistosoma mansoni	axis inhibition protein axin	0.0165	0.1267	0.1267
Echinococcus granulosus	dnaJ subfamily B	0.0408	0.319	0.3174
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0165	0.1267	0.1267
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0031	0.0206	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0031	0.0206	0.1412
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0031	0.0206	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0083	0.0046
Schistosoma mansoni	zinc finger protein	0.0027	0.0174	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0165	0.1267	0.3095
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0322	0.0322
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.02	0.02
Echinococcus granulosus	cytohesin 1	0.0027	0.0174	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0031	0.0206	1
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Loa Loa (eye worm)	RGS-3 protein	0.0165	0.1267	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0322	0.0299
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0031	0.0206	0.1412
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0038	0.0014
Schistosoma mansoni	hypothetical protein	0.0016	0.0083	0.0083
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0038	0.0014
Echinococcus granulosus	oxysterol binding protein 1	0.0027	0.0174	0.0151
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0347	0.2704	0.2677
Echinococcus granulosus	Oxysterol binding protein 11	0.0027	0.0174	0.0151
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0027	0.0174	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus multilocularis	Pleckstrin y	0.0027	0.0174	0.0151
Schistosoma mansoni	cpg binding protein	0.003	0.0199	0.0199
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1103	0.8691	0.8688
Echinococcus granulosus	muscleblind protein	0.0155	0.1185	0.1164
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0031	0.0206	1
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0027	0.0174	0.0151
Loa Loa (eye worm)	uncoordinated protein 104	0.0027	0.0174	0.0137
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0031	0.0206	0.1072
Trichomonas vaginalis	protein transport protein sec7, putative	0.0027	0.0174	0.09
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0165	0.1267	0.689
Loa Loa (eye worm)	Plekhf2 protein	0.0027	0.0174	0.0137
Leishmania major	protein kinase, putative	0.0031	0.0206	1
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0031	0.0206	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Echinococcus granulosus	regulator of G protein signaling 7	0.0165	0.1267	0.1247
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0027	0.0174	0.0151
Echinococcus granulosus	pleckstrin y domain containing family A	0.0027	0.0174	0.0151
Schistosoma mansoni	serine/threonine-protein kinase	0.0031	0.0206	0.0206
Trypanosoma cruzi	Protein kinase B	0.0031	0.0206	1
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0027	0.0174	0.09
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0027	0.0174	0.0151
Trichomonas vaginalis	centaurin alpha, putative	0.0027	0.0174	0.09
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0083	0.0117
Echinococcus granulosus	dynamin 1	0.0027	0.0174	0.0151
Brugia malayi	Dynamin	0.0027	0.0174	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Entamoeba histolytica	hypothetical protein	0.0031	0.0206	0.0288
Entamoeba histolytica	hypothetical protein	0.0031	0.0206	0.0288
Schistosoma mansoni	syntrophin	0.0027	0.0174	0.0174
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0027	0.0174	0.0151
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0031	0.0206	1
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0027	0.0174	0.0151
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0083	0.006
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0027	0.0174	0.0346
Echinococcus multilocularis	regulator of G protein signaling 7	0.0165	0.1267	0.1247
Onchocerca volvulus		0.0237	0.1835	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0322	0.0322
Echinococcus multilocularis	regulator of G protein signaling 3	0.0165	0.1267	0.1247
Trichomonas vaginalis	centaurin gamma, putative	0.0027	0.0174	0.09
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Echinococcus granulosus	myotubularin protein 13	0.0027	0.0174	0.0151
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0027	0.0174	0.0151
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0206	0.0425
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0027	0.0174	0.09
Trichomonas vaginalis	hypothetical protein	0.0027	0.0174	0.09
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0027	0.0174	0.0346
Schistosoma mansoni	oxysterol-binding protein 1	0.0027	0.0174	0.0174
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1103	0.8691	0.8688
Loa Loa (eye worm)	syntrophin-1	0.0027	0.0174	0.0137
Schistosoma mansoni	serine/threonine protein kinase	0.1268	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0174	0.0346
Brugia malayi	hypothetical protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus multilocularis	dnaJ subfamily B	0.0408	0.319	0.3174
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0031	0.0206	0.1072
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0353	0.0794
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0174	0.0346
Leishmania major	folate/biopterin transporter, putative	0.0031	0.0206	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Brugia malayi	PXA domain containing protein	0.0165	0.1267	0.3095
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0027	0.0174	0.09
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Brugia malayi	Oxysterol binding protein	0.0027	0.0174	0.0346
Echinococcus granulosus	Pleckstrin y	0.0027	0.0174	0.0151
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0027	0.0174	0.0151
Echinococcus granulosus	axis inhibition protein axin	0.0165	0.1267	0.1247
Brugia malayi	regulator of G-protein signaling rgs-7	0.0165	0.1267	0.3095
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Entamoeba histolytica	hypothetical protein	0.0165	0.1267	1
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus granulosus	regulator of G protein signaling 3	0.0165	0.1267	0.1247
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0165	0.1267	0.1234
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	A-kinase anchor protein 10, precursor	0.0165	0.1267	0.3095
Brugia malayi	PXA domain containing protein	0.0165	0.1267	0.3095
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0027	0.0174	0.0151
Echinococcus multilocularis	oxysterol binding protein 1	0.0027	0.0174	0.0151
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Schistosoma mansoni	vav2	0.0027	0.0174	0.0174
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0027	0.0174	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0031	0.0206	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0347	0.2704	0.6709
Echinococcus multilocularis	regulator of G protein signaling	0.0165	0.1267	0.1247

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 7.5 mm	Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay	ChEMBL.	24044873
MIC (functional)	= 416.7 ug ml-1	Antibacterial activity against Escherichia coli ATCC 8099 assessed as growth inhibition after 24 hrs by liquid dilution method	ChEMBL.	24044873

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2437006

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1789219