TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 540.745 | Formula: C23H12Cl3N7O3
H donors: 3 H acceptors: 5 LogP: 5.86 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1c(Nc2ccc(cc2Nc2ccc(c3c2c(=O)[nH]cn3)[N+](=O)[O-])C)c(Cl)c(c(c1Cl)C#N)Cl
InChi: 1S/C23H12Cl3N7O3/c1-10-2-3-13(32-21-12(8-28)18(24)11(7-27)19(25)20(21)26)15(6-10)31-14-4-5-16(33(35)36)22-17(14)23(34)30-9-29-22/h2-6,9,31-32H,1H3,(H,29,30,34)
InChiKey: MCPWYBAQQIMSLO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0031	0.0206	0.0288
Brugia malayi	hypothetical protein	0.0027	0.0174	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0165	0.1267	0.1267
Schistosoma mansoni	vav2	0.0027	0.0174	0.0174
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0174	0.0346
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0031	0.0206	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0165	0.1267	0.1267
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0031	0.0206	0.0169
Onchocerca volvulus		0.003	0.02	0.0152
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0027	0.0174	0.0151
Entamoeba histolytica	hypothetical protein	0.0165	0.1267	1
Echinococcus multilocularis	Oxysterol binding protein 11	0.0027	0.0174	0.0151
Echinococcus multilocularis	regulator of G protein signaling	0.0165	0.1267	0.1247
Brugia malayi	Oxysterol binding protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0027	0.0174	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Echinococcus granulosus	calcium dependent secretion activator 1	0.0027	0.0174	0.0151
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.02	0.02
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0165	0.1267	0.1247
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1268	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1103	0.8691	0.8688
Echinococcus multilocularis	muscleblind protein 1	0.0155	0.1185	0.1164
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0322	0.0299
Echinococcus granulosus	serine/threonine protein kinase	0.0031	0.0206	0.0182
Echinococcus granulosus	DCC interacting protein 13 beta	0.0027	0.0174	0.0151
Schistosoma mansoni	hypothetical protein	0.0034	0.0228	0.0228
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0322	0.0285
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	protein transport protein sec7, putative	0.0027	0.0174	0.09
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Brugia malayi	hypothetical protein	0.0165	0.1267	0.3095
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	Cadps2 protein	0.0027	0.0174	0.0346
Schistosoma mansoni	centaurin alpha	0.0027	0.0174	0.0174
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0165	0.1267	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0228	0.0191
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0027	0.0174	0.0151
Echinococcus multilocularis	Pleckstrin y	0.0027	0.0174	0.0151
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0038	0.0014
Schistosoma mansoni	dynamin	0.0027	0.0174	0.0174
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0347	0.2704	0.2687
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0027	0.0174	0.0151
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0083	0.006
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Trichomonas vaginalis	centaurin alpha, putative	0.0027	0.0174	0.09
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Schistosoma mansoni	axis inhibition protein axin	0.0165	0.1267	0.1267
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.02	0.02
Brugia malayi	Cytohesin 3	0.0027	0.0174	0.0346
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Entamoeba histolytica	hypothetical protein	0.0031	0.0206	0.0288
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0347	0.2704	0.2677
Brugia malayi	regulator of G-protein signaling rgs-7	0.0165	0.1267	0.3095
Loa Loa (eye worm)	PXA domain-containing protein	0.0165	0.1267	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	alpha chimerin, putative	0.0027	0.0174	0.09
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0027	0.0174	0.09
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Echinococcus multilocularis	axis inhibition protein axin	0.0165	0.1267	0.1247
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0027	0.0174	0.0151
Brugia malayi	Oxysterol-binding protein	0.0027	0.0174	0.0346
Brugia malayi	regulator of G-protein signaling egl-10	0.0165	0.1267	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0322	0.0299
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.1608	0.1576
Echinococcus granulosus	GRB2 associated binding protein 3	0.0027	0.0174	0.0151
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0027	0.0174	0.0346
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0174	0.0346
Trypanosoma cruzi	Protein kinase B	0.0031	0.0206	1
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Schistosoma mansoni	serine/threonine-protein kinase	0.0031	0.0206	0.0206
Echinococcus granulosus	Oxysterol binding protein 11	0.0027	0.0174	0.0151
Echinococcus multilocularis	muscleblind protein	0.0155	0.1185	0.1164
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0353	0.0316
Echinococcus granulosus	regulator of G protein signaling 7	0.0165	0.1267	0.1247
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Echinococcus granulosus	axis inhibition protein axin	0.0165	0.1267	0.1247
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Trypanosoma cruzi	NIMA-related kinase, putative	0.0031	0.0206	1
Echinococcus granulosus	Rho GTPase activating protein 24	0.0027	0.0174	0.0151
Echinococcus granulosus	oxysterol binding protein 1	0.0027	0.0174	0.0151
Echinococcus multilocularis	actin binding protein anillin	0.0027	0.0174	0.0151
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0027	0.0174	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Brugia malayi	Dynamin	0.0027	0.0174	0.0346
Trypanosoma cruzi	NIMA-related kinase, putative	0.0031	0.0206	1
Brugia malayi	Pleckstrin Homology Domain	0.0027	0.0174	0.0346
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0031	0.0206	0.1072
Schistosoma mansoni	dynamin	0.0027	0.0174	0.0174
Brugia malayi	Uncoordinated protein 104	0.0027	0.0174	0.0346
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trichomonas vaginalis	centaurin/arf, putative	0.0027	0.0174	0.09
Echinococcus granulosus	Pleckstrin y	0.0027	0.0174	0.0151
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0027	0.0174	0.09
Schistosoma mansoni	goodpasture antigen-binding protein	0.0027	0.0174	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0031	0.0206	0.1412
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0186	0.0149
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.02	0.113
Echinococcus granulosus	cpg binding protein	0.003	0.0199	0.0175
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.02	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Echinococcus multilocularis	dynamin 1	0.0027	0.0174	0.0151
Brugia malayi	Pre-SET motif family protein	0.003	0.02	0.0409
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0027	0.0174	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Schistosoma mansoni	goodpasture antigen-binding protein	0.0027	0.0174	0.0174
Echinococcus multilocularis	regulator of G protein signaling 3	0.0165	0.1267	0.1247
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0031	0.0206	1
Trichomonas vaginalis	kinesin light chain, putative	0.0027	0.0174	0.09
Echinococcus multilocularis	regulator of G protein signaling 7	0.0165	0.1267	0.1247
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0024	0.0024
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0027	0.0174	0.0174
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0027	0.0174	0.0346
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0083	0.006
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Plasmodium vivax	SET domain protein, putative	0.003	0.02	0.8004
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0031	0.0206	1
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0031	0.0206	0.1072
Leishmania major	serine/threonine-protein kinase a, putative	0.0031	0.0206	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0083	0.0083
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Echinococcus granulosus	regulator of G protein signaling 3	0.0165	0.1267	0.1247
Brugia malayi	Plekhf2 protein	0.0027	0.0174	0.0346
Echinococcus multilocularis	cpg binding protein	0.003	0.0199	0.0175
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Schistosoma mansoni	hypothetical protein	0.0016	0.0083	0.0083
Schistosoma mansoni	cpg binding protein	0.003	0.0199	0.0199
Schistosoma mansoni	hypothetical protein	0.0016	0.0083	0.0083
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0512	0.4013	0.399
Schistosoma mansoni	oxysterol-binding protein 1	0.0027	0.0174	0.0174
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Entamoeba histolytica	p21-activated kinase	0.0031	0.0206	0.0288
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.1835	1
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Echinococcus granulosus	regulator of G protein signaling 3	0.0165	0.1267	0.1247
Echinococcus granulosus	Regulator of G protein signaling 20	0.0165	0.1267	0.1247
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Echinococcus multilocularis	dnaJ subfamily B	0.0408	0.319	0.3174
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0027	0.0174	0.0137
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0031	0.0206	1
Schistosoma mansoni	serine/threonine protein kinase	0.1268	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0031	0.0206	0.1412
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Echinococcus multilocularis	pdz domain containing protein	0.0027	0.0174	0.0151
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0165	0.1267	0.3095
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0031	0.0206	1
Loa Loa (eye worm)	uncoordinated protein 104	0.0027	0.0174	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0031	0.0206	1
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus multilocularis	axis inhibition protein axin	0.0165	0.1267	0.1247
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0031	0.0206	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0083	0.0046
Echinococcus granulosus	regulator of G protein signaling 7	0.0165	0.1267	0.1247
Schistosoma mansoni	serine/threonine-protein kinase	0.0031	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0083	0.006
Schistosoma mansoni	oxysterol-binding protein 1	0.0027	0.0174	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0027	0.0174	0.0174
Echinococcus multilocularis	Pleckstrin y	0.0027	0.0174	0.0151
Schistosoma mansoni	hypothetical protein	0.0408	0.319	0.319
Echinococcus multilocularis	oxysterol binding protein 3	0.0027	0.0174	0.0151
Trichomonas vaginalis	protein transport protein sec7, putative	0.0027	0.0174	0.09
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Brugia malayi	Muscleblind-like protein	0.0155	0.1185	0.2889
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0027	0.0174	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Schistosoma mansoni	cpg binding protein	0.0029	0.0186	0.0186
Echinococcus multilocularis	Pleckstrin y	0.0027	0.0174	0.0151
Loa Loa (eye worm)	hypothetical protein	0.003	0.02	0.0163
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Trypanosoma brucei	protein kinase, putative	0.0031	0.0206	1
Echinococcus granulosus	dynamin 1	0.0027	0.0174	0.0151
Echinococcus granulosus	cytohesin 1	0.0027	0.0174	0.0151
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0031	0.0206	1
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0322	0.0299
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0031	0.0206	1
Onchocerca volvulus		0.0029	0.0186	0.0068
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0353	0.0794
Schistosoma mansoni	axis inhibition protein axin	0.0165	0.1267	0.1267
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0027	0.0174	0.0151
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0397	1
Brugia malayi	TBC domain containing protein	0.0027	0.0174	0.0346
Brugia malayi	PXA domain containing protein	0.0165	0.1267	0.3095
Loa Loa (eye worm)	syntrophin-1	0.0027	0.0174	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus granulosus	pleckstrin y domain containing family A	0.0027	0.0174	0.0151
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0031	0.0206	1
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0027	0.0174	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0165	0.1267	0.689
Brugia malayi	Dynamin	0.0027	0.0174	0.0346
Echinococcus granulosus	dnaJ subfamily B	0.0408	0.319	0.3174
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0031	0.0206	1
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus multilocularis	cytohesin 1	0.0027	0.0174	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0027	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0027	0.0174	0.09
Loa Loa (eye worm)	oxysterol binding protein	0.0027	0.0174	0.0137
Echinococcus granulosus	beta 1 syntrophin	0.0027	0.0174	0.0151
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0186	0.0374
Echinococcus multilocularis	oxysterol binding protein 1	0.0027	0.0174	0.0151
Loa Loa (eye worm)	PH domain-containing protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0347	0.2704	0.6709
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0083	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Onchocerca volvulus		0.0237	0.1835	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0186	0.0162
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0027	0.0174	0.0151
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.02	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0031	0.0206	1
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0027	0.0174	0.000000090368
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0027	0.0174	0.0137
Schistosoma mansoni	syntrophin	0.0027	0.0174	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1268	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0165	0.1267	0.1247
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0165	0.1267	0.1247
Echinococcus granulosus	GPCR family 2	0.0016	0.0083	0.006
Brugia malayi	probable spectrin beta chain	0.0027	0.0174	0.0346
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0027	0.0174	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0083	0.006
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0031	0.0206	1
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0027	0.0174	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1267	0.689
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1185	0.1152
Brugia malayi	Syntrophin-1	0.0027	0.0174	0.0346
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0027	0.0174	0.0151
Entamoeba histolytica	hypothetical protein	0.0165	0.1267	1
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0165	0.1267	0.1234
Entamoeba histolytica	hypothetical protein	0.0165	0.1267	1
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0083	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0031	0.0206	1
Echinococcus granulosus	oxysterol binding protein 3	0.0027	0.0174	0.0151
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0038	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1185	0.1152
Schistosoma mansoni	myotubularin-related protein	0.0027	0.0174	0.0174
Brugia malayi	Pre-SET motif family protein	0.0208	0.1608	0.3951
Leishmania major	protein kinase, putative	0.0031	0.0206	1
Echinococcus multilocularis	myotubularin protein 13	0.0027	0.0174	0.0151
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0027	0.0174	0.0151
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0353	0.0794
Brugia malayi	PXA domain containing protein	0.0165	0.1267	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0027	0.0174	0.09
Schistosoma mansoni	zinc finger protein	0.0027	0.0174	0.0174
Echinococcus multilocularis	expressed protein	0.0165	0.1267	0.1247
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Brugia malayi	MAX-1A	0.0027	0.0174	0.0346
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0031	0.0206	1
Leishmania major	protein kinase, putative	0.0031	0.0206	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus granulosus	pdz domain containing protein	0.0027	0.0174	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Echinococcus granulosus	expressed protein	0.0165	0.1267	0.1247
Echinococcus multilocularis	beta 1 syntrophin	0.0027	0.0174	0.0151
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.02	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0027	0.0174	0.0151
Echinococcus granulosus	axis inhibition protein axin	0.0165	0.1267	0.1247
Loa Loa (eye worm)	rho-GTPase-activating	0.0027	0.0174	0.0137
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0228	0.0481
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0322	0.0322
Trichomonas vaginalis	centaurin gamma, putative	0.0027	0.0174	0.09
Schistosoma mansoni	cpg binding protein	0.003	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Leishmania major	folate/biopterin transporter, putative	0.0031	0.0206	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.02	0.0176
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1103	0.8691	0.8688
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Brugia malayi	PH domain containing protein	0.0027	0.0174	0.0346
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0031	0.0206	1
Trichomonas vaginalis	hypothetical protein	0.0027	0.0174	0.09
Echinococcus multilocularis	regulator of G protein signaling 7	0.0165	0.1267	0.1247
Loa Loa (eye worm)	hypothetical protein	0.005	0.0353	0.0316
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0027	0.0174	0.0137
Trichomonas vaginalis	centaurin/arf, putative	0.0027	0.0174	0.09
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Loa Loa (eye worm)	Plekhf2 protein	0.0027	0.0174	0.0137
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0512	0.4013	1
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0027	0.0174	0.0151
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0206	0.0425
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0027	0.0174	0.09
Loa Loa (eye worm)	RGS-3 protein	0.0165	0.1267	0.1234
Echinococcus multilocularis	rac serine:threonine kinase	0.0031	0.0206	0.0182
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0027	0.0174	0.0151
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0449	0.0449
Echinococcus granulosus	muscleblind protein	0.0155	0.1185	0.1164
Trichomonas vaginalis	centaurin beta, putative	0.0027	0.0174	0.09
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0322	0.0322
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0027	0.0174	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0031	0.0206	1
Loa Loa (eye worm)	cytohesin 3	0.0027	0.0174	0.0137
Entamoeba histolytica	protein kinase, putative	0.0031	0.0206	0.0288
Schistosoma mansoni	hypothetical protein	0.0027	0.0174	0.0174
Echinococcus granulosus	myotubularin protein 13	0.0027	0.0174	0.0151
Brugia malayi	A-kinase anchor protein 10, precursor	0.0165	0.1267	0.3095
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0083	0.0117
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0027	0.0174	0.0151
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0027	0.0174	0.0151
Echinococcus granulosus	Pleckstrin y	0.0027	0.0174	0.0151
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0347	0.2704	0.2687
Echinococcus multilocularis	oxysterol binding protein 9	0.0027	0.0174	0.0151
Schistosoma mansoni	hypothetical protein	0.0016	0.0083	0.0083
Echinococcus multilocularis	regulator of G protein signaling 3	0.0165	0.1267	0.1247
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0083	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0027	0.0174	0.0151
Schistosoma mansoni	growth factor receptor-bound protein	0.0027	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0165	0.1267	0.3095
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Echinococcus granulosus	Pleckstrin y	0.0027	0.0174	0.0151
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0031	0.0206	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.02	0.0176
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0206	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1267	0.1234
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Echinococcus granulosus	oxysterol binding protein 9	0.0027	0.0174	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0174	0.09
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0322	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0027	0.0174	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Schistosoma mansoni	regulator of G protein signaling	0.0165	0.1267	0.1267
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0027	0.0174	0.0151
Schistosoma mansoni	serine/threonine protein kinase	0.1268	1	1
Schistosoma mansoni	z-protein (S1r protein)	0.0165	0.1267	0.1267
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0347	0.2704	0.2677
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0174	0.0137
Schistosoma mansoni	zinc finger protein	0.0027	0.0174	0.0174
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0322	0.0717
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0031	0.0206	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0322	0.0322
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0165	0.1267	0.1267
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0027	0.0174	0.09
Schistosoma mansoni	rho gtpase activating protein	0.0027	0.0174	0.0174
Schistosoma mansoni	serine/threonine protein kinase	0.0512	0.4013	0.4013

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 7.5 mm	Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay	ChEMBL.	24044873
MIC (functional)	= 416.7 ug ml-1	Antibacterial activity against Escherichia coli ATCC 8099 assessed as growth inhibition after 24 hrs by liquid dilution method	ChEMBL.	24044873

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2437006

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1789219