Detailed information for compound 1791728

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 253.256 | Formula: C14H11N3O2
  • H donors: 1 H acceptors: 1 LogP: 1.34 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)c1ccc(nc1)c1ccc(o1)c1ccco1
  • InChi: 1S/C14H11N3O2/c15-14(16)9-3-4-10(17-8-9)11-5-6-13(19-11)12-2-1-7-18-12/h1-8H,(H3,15,16)
  • InChiKey: PMZSCKMLQPLUNU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0041 0.0041
Echinococcus multilocularis cysteine protease 0.003 0.0092 0.0092
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.003 0.0092 0.0222
Trichomonas vaginalis importin beta-1, putative 0.0053 0.0209 0.0583
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0809 0.4119 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.0877 0.213
Entamoeba histolytica hypothetical protein 0.0032 0.0104 0.0859
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0104 0.0104
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0058 0.0465
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0129 0.2449
Brugia malayi RNA binding protein 0.0069 0.0291 0.0707
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0122 0.0341
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0028 0.0711
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0022 0.0052 0.0052
Trichomonas vaginalis set domain proteins, putative 0.0706 0.359 1
Schistosoma mansoni smad1 5 8 and 0.0022 0.0052 0.0052
Brugia malayi glutathione reductase 0.0084 0.0373 0.0905
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Onchocerca volvulus 0.003 0.0092 0.0228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0088 0.2349
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0092 0.0759
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0016 0.0124
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0021 0.0021
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0098
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0214 0.1043 0.8434
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0373 0.0905
Echinococcus granulosus survival motor neuron protein 1 0.0198 0.096 0.096
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0088 0.1659
Echinococcus multilocularis Regulator of G protein signaling 20 0.0081 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Echinococcus granulosus GPCR family 2 0.0031 0.0099 0.0099
Brugia malayi regulator of G-protein signaling egl-10 0.0081 0.0354 0.0858
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0129 0.0129
Echinococcus multilocularis cysteine protease 0.003 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0122 0.0122
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.001 0.001
Onchocerca volvulus 0.0039 0.0139 0.0361
Echinococcus multilocularis cathepsin l cysteine peptidase 0.003 0.0092 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0139 0.0388
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0081 0.0354 0.0354
Loa Loa (eye worm) nuclear factor I 0.0012 0 0.0001
Brugia malayi Pre-SET motif family protein 0.0621 0.3146 0.7638
Loa Loa (eye worm) hypothetical protein 0.017 0.0815 0.1978
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.001 0.0187
Onchocerca volvulus 0.004 0.0146 0.0379
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0877 0.0877
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0016 0.0135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0877 0.0877
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0139 0.0967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0188 0.0524
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Onchocerca volvulus 0.0706 0.359 1
Echinococcus granulosus axis inhibition protein axin 0.0081 0.0354 0.0354
Entamoeba histolytica hypothetical protein 0.0032 0.0104 0.0859
Brugia malayi hypoxia-induced factor 1 0.0169 0.0812 0.197
Echinococcus granulosus beta-adrenergic receptor kinase 0.0083 0.0364 0.0364
Onchocerca volvulus 0.002 0.004 0.0085
Mycobacterium ulcerans putative regulatory protein 0.004 0.0146 0.0822
Brugia malayi Importin beta-1 subunit 0.0065 0.0273 0.0663
Plasmodium vivax vivapain-3 0.0015 0.0016 0.041
Brugia malayi Pre-SET motif family protein 0.0089 0.0397 0.0963
Mycobacterium ulcerans hypothetical protein 0.0039 0.0139 0.0777
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0081 0.0354 0.0354
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0139 0.3508
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0397 0.0397
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0028 0.0534
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Onchocerca volvulus 0.017 0.0815 0.2248
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0028 0.0757
Schistosoma mansoni smad1 5 8 and 0.0022 0.0052 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0291 0.0707
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0048 0.0184 0.1231
Echinococcus multilocularis regulator of G protein signaling 3 0.0081 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0088 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0053 0.0209 0.0583
Schistosoma mansoni intermediate filament proteins 0.0023 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0028 0.005
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.002 0.0194
Loa Loa (eye worm) PXA domain-containing protein 0.0081 0.0354 0.0858
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0877 0.0877
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0055 0.1051
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0098
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.002 0.0194
Echinococcus granulosus histone lysine methyltransferase setb 0.0089 0.0397 0.0397
Entamoeba histolytica cysteine proteinase 1, putative 0.0015 0.0016 0.0135
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0041 0.0336
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0449 0.109
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0139 0.0388
Onchocerca volvulus 0.003 0.0092 0.0228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Echinococcus granulosus regulator of G protein signaling 7 0.0081 0.0354 0.0354
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0695 0.3529 0.8568
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0041 0.0592
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0047 0.0115
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0016 0.0124
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0028 0.0068
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0122 0.2317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Onchocerca volvulus 0.003 0.0092 0.0228
Echinococcus multilocularis mothers against decapentaplegic 5 0.0022 0.0052 0.0052
Onchocerca volvulus 0.0023 0.0053 0.0121
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0083 0.0364 0.0883
Echinococcus multilocularis neuropeptide s receptor 0.052 0.2624 0.2624
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0041 0.0768
Brugia malayi hypothetical protein 0.0183 0.0885 0.2149
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.001 0.0027
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0188 0.3567
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0048 0.0184 0.0184
Echinococcus multilocularis lamin dm0 0.0023 0.0053 0.0053
Leishmania major protein kinase, putative 0.0016 0.002 0.0377
Schistosoma mansoni Smad4 0.0022 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0105 0.0293
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0088 0.0088
Echinococcus granulosus dna polymerase eta 0.002 0.0041 0.0041
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0088 0.1659
Brugia malayi MH2 domain containing protein 0.0328 0.1633 0.3964
Entamoeba histolytica hypothetical protein 0.0053 0.0209 0.1735
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0129 0.0761
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0021 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0016 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Loa Loa (eye worm) hypothetical protein 0.0138 0.0649 0.1575
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0122 0.0122
Onchocerca volvulus 0.003 0.0092 0.0228
Toxoplasma gondii exonuclease III APE 0.0037 0.0129 0.3257
Brugia malayi Regulator of G protein signaling domain containing protein 0.0081 0.0354 0.0858
Echinococcus multilocularis regulator of G protein signaling 0.0081 0.0354 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.003 0.0092 0.0255
Schistosoma mansoni axis inhibition protein axin 0.0081 0.0354 0.0354
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0004 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0058 0.048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0303 0.1914
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0373 0.2896
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0041 0.0098
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.001 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0809 0.4119 0.4119
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1659
Loa Loa (eye worm) fibroinase 0.003 0.0092 0.0222
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0809 0.4119 1
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0303 0.7637
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0041 0.0098
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.0397 1
Toxoplasma gondii ABC1 family protein 0.0039 0.0139 0.3508
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0449 0.109
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0139 0.0777
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0214 0.1043 0.8434
Onchocerca volvulus 0.0023 0.0053 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0058 0.0213
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0033 0.0108 0.4941
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0021 0.0394
Plasmodium vivax vivapain-2 0.003 0.0092 0.2307
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0028 0.0028
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0108 0.0562
Schistosoma mansoni glutaminase 0.0296 0.1468 0.1468
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0041 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0108 0.1898
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0188 0.3445
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0621 0.3146 0.7638
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.0932 0.7516
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0099 0.0239
Echinococcus granulosus neuropeptide s receptor 0.052 0.2624 0.2624
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0202
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0041 0.0768
Brugia malayi beta-lactamase family protein 0.0039 0.0139 0.0338
Echinococcus multilocularis survival motor neuron protein 1 0.0198 0.096 0.096
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0129 0.3467
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0184 0.3365
Leishmania major cathepsin L-like protease 0.0114 0.0528 1
Echinococcus granulosus single minded 2 0.004 0.0146 0.0146
Brugia malayi hypothetical protein 0.0032 0.0104 0.0252
Onchocerca volvulus 0.003 0.0092 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0016 0.0309
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0088 0.0403
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0058 0.0141
Mycobacterium leprae Probable lipase LipE 0.0039 0.0139 0.1252
Mycobacterium tuberculosis Conserved protein 0.0039 0.0139 0.0967
Schistosoma mansoni ran 0.0048 0.0184 0.0184
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0014 0.001 0.019
Plasmodium falciparum cysteine proteinase falcipain 3 0.003 0.0092 0.2456
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0303 0.1914
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0201
Echinococcus multilocularis regulator of G protein signaling 3 0.0081 0.0354 0.0354
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0088 0.2206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Echinococcus granulosus cathepsin l1 0.003 0.0092 0.0092
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0088 0.1659
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0028 0.0028
Entamoeba histolytica cysteine protease, putative 0.003 0.0092 0.0759
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0028 0.0354
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0129 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0188 0.0524
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0188 0.156
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0139 0.0388
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Onchocerca volvulus 0.0039 0.0139 0.0361
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.001 0.001
Schistosoma mansoni ap endonuclease 0.0037 0.0129 0.0129
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0088 0.1501
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0129 0.0884
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1659
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0139 0.0777
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0108 0.0301
Loa Loa (eye worm) transcription factor SMAD2 0.0328 0.1633 0.3964
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Toxoplasma gondii cathepsin CPL 0.003 0.0092 0.2307
Echinococcus granulosus intermediate filament protein 0.0023 0.0053 0.0053
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0303 0.0303
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0138 0.0649 0.1575
Leishmania major cathepsin L-like protease 0.0114 0.0528 1
Brugia malayi hypothetical protein 0.0138 0.0649 0.1575
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0016 0.0309
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0122 0.0122
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.0932 0.7516
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.0092 0.0092
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0155
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0058 0.1097
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0016 0.0135
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0058 0.0295
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0129 0.3257
Echinococcus granulosus cathepsin l1 0.002 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0129
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0129 0.2306
Schistosoma mansoni microtubule-associated protein tau 0.1946 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0246 0.1206 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0139 0.0139
Brugia malayi MH1 domain containing protein 0.0022 0.0052 0.0126
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0108 0.205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0877 0.0877
Schistosoma mansoni lamin 0.0023 0.0053 0.0053
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0188 0.3567
Schistosoma mansoni single-minded 0.0055 0.0219 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Echinococcus multilocularis snurportin 1 0.0695 0.3529 0.3529
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0303 0.0303
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0139 0.0338
Loa Loa (eye worm) RGS-3 protein 0.0081 0.0354 0.0858
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0041 0.0093
Leishmania major GTP-binding protein, putative 0.0048 0.0184 0.3488
Echinococcus multilocularis cathepsin L cysteine protease 0.003 0.0092 0.0092
Schistosoma mansoni inositol monophosphatase 0.0033 0.0108 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Echinococcus multilocularis dna polymerase eta 0.002 0.0041 0.0041
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0122 0.0297
Plasmodium vivax vivapain-1 0.0015 0.0016 0.041
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0155
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0219 0.0219
Treponema pallidum fructose-bisphosphate aldolase 0.0246 0.1206 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0027 0.0041
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0695 0.3529 0.3529
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0092 0.0759
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0195 0.0195
Echinococcus granulosus geminin 0.0673 0.3414 0.3414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Brugia malayi beta-lactamase family protein 0.0039 0.0139 0.0338
Mycobacterium tuberculosis Conserved protein 0.0039 0.0139 0.0967
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0028 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0058 0.1097
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0048 0.0184 0.4639
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0139 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Brugia malayi MH1 domain containing protein 0.0012 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0087 0.0242
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0089 0.0397 0.0397
Echinococcus granulosus cathepsin l cysteine peptidase 0.003 0.0092 0.0092
Entamoeba histolytica hypothetical protein 0.0081 0.0354 0.2931
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0104 0.0476 0.9009
Schistosoma mansoni hypothetical protein 0.0068 0.0287 0.0287
Brugia malayi hypothetical protein 0.0081 0.0354 0.0858
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0139 0.0967
Brugia malayi PXA domain containing protein 0.0081 0.0354 0.0858
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.004 0.0145 0.0352
Brugia malayi Ets-domain containing protein 0.0079 0.0344 0.0836
Echinococcus granulosus dna polymerase kappa 0.002 0.0041 0.0041
Trypanosoma cruzi cysteine protease, putative 0.0015 0.0016 0.0124
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0273 0.5173
Plasmodium vivax unspecified product 0.0015 0.0016 0.041
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0192 0.0932 0.8925
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Loa Loa (eye worm) hypothetical protein 0.0183 0.0885 0.2149
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0201
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0877 0.0877
Echinococcus multilocularis expressed protein 0.0081 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) hypoxia-induced factor 1 0.0169 0.0812 0.197
Echinococcus granulosus snurportin 1 0.0695 0.3529 0.3529
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0728 0.3702 0.3702
Brugia malayi MH2 domain containing protein 0.0022 0.0052 0.0126
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.012 0.0557 0.5295
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0129 0.2306
Plasmodium vivax glutathione reductase, putative 0.0084 0.0373 0.9393
Mycobacterium ulcerans glutaminase 0.0296 0.1468 1
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0528 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0137 0.2454
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Loa Loa (eye worm) hypothetical protein 0.0089 0.0397 0.0963
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Onchocerca volvulus Cathepsin L homolog 0.003 0.0092 0.0228
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0048 0.0184 0.4939
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0291 0.0291
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Echinococcus granulosus GTP binding nuclear protein Ran 0.0048 0.0184 0.0184
Schistosoma mansoni gabp alpha 0.0079 0.0344 0.0344
Onchocerca volvulus 0.0039 0.0139 0.0361
Giardia lamblia Fructose-bisphosphate aldolase 0.0246 0.1206 1
Echinococcus multilocularis musashi 0.0023 0.0053 0.0053
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0088 0.0088
Echinococcus multilocularis microtubule associated protein 2 0.1946 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0088 0.2206
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0122 0.1013
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0021 0.0394
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0098
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0122 0.2171
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.0877 0.213
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0028 0.0534
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0129 0.1071
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0373 0.7008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0129 0.0372
Trichomonas vaginalis esterase, putative 0.0039 0.0139 0.0388
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Echinococcus multilocularis importin subunit beta 1 0.0065 0.0273 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0188 0.0524
Entamoeba histolytica cysteine proteinase 2 0.0015 0.0016 0.0135
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0528 1
Echinococcus multilocularis neuropeptide receptor A26 0.052 0.2624 0.2624
Onchocerca volvulus Cathepsin L homolog 0.003 0.0092 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0201
Echinococcus granulosus tar DNA binding protein 0.0069 0.0291 0.0291
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0028 0.0028
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0188 0.3445
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0592
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.0397 0.0397
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.001 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0099 0.0239
Brugia malayi Ets-domain containing protein 0.0079 0.0344 0.0836
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0088 0.0244
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0022 0.0052 0.0052
Echinococcus granulosus tumor protein p63 0.0342 0.1703 0.1703
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0052 0.0126
Plasmodium falciparum cysteine proteinase falcipain 2b 0.003 0.0092 0.2456
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0016 0.0124
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0303 0.0303
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0016 0.0135
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0728 0.3702 0.8987
Brugia malayi isocitrate dehydrogenase 0.0018 0.0028 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Onchocerca volvulus 0.005 0.0195 0.0517
Echinococcus granulosus regulator of G protein signaling 7 0.0081 0.0354 0.0354
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0088 0.2349
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0139 0.2638
Entamoeba histolytica hypothetical protein 0.0081 0.0354 0.2931
Trypanosoma cruzi major cysteine proteinase, putative 0.009 0.0401 0.7556
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0473
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0297
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0088 0.2206
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0202
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0108 0.0108
Loa Loa (eye worm) MH2 domain-containing protein 0.0328 0.1633 0.3964
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.002 0.0194
Brugia malayi regulator of G-protein signaling rgs-7 0.0081 0.0354 0.0858
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0028 0.0028
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0081 0.0354 0.0858
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0041 0.0776
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Onchocerca volvulus 0.004 0.0145 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0202
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0124
Echinococcus granulosus expressed protein 0.0081 0.0354 0.0354
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0108 0.0108
Mycobacterium ulcerans lipase LipD 0.0039 0.0139 0.0777
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0287 0.0696
Echinococcus granulosus lamin 0.0023 0.0053 0.0053
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0108 0.0301
Trypanosoma brucei unspecified product 0.002 0.0041 0.0768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Loa Loa (eye worm) Smad1 0.0022 0.0052 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0016 0.0045
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0124 0.3117
Brugia malayi beta-lactamase 0.0039 0.0139 0.0338
Echinococcus granulosus TGF beta signal transducer SmadC 0.0022 0.0052 0.0052
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0041 0.0768
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0122 0.0122
Mycobacterium tuberculosis Conserved protein 0.0039 0.0139 0.0967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0027 0.2229
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0058 0.0213
Echinococcus multilocularis regulator of G protein signaling 7 0.0081 0.0354 0.0354
Schistosoma mansoni ran 0.0048 0.0184 0.0184
Entamoeba histolytica hypothetical protein 0.0032 0.0104 0.0859
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0053 0.0129
Echinococcus multilocularis tumor protein p63 0.0342 0.1703 0.1703
Entamoeba histolytica cysteine proteinase, putative 0.002 0.004 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0155
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0081 0.0354 0.0354
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0108 0.205
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0137 0.2595
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0027 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0397 0.0397
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0041 0.0768
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.001 0.0024
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0041 0.0098
Onchocerca volvulus 0.0089 0.0397 0.1081
Echinococcus granulosus cathepsin L cysteine protease 0.0015 0.0016 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0303 0.1914
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0449 0.109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0087 0.0242
Trichomonas vaginalis glutaminase, putative 0.0296 0.1468 0.4091
Brugia malayi cathepsin L-like precursor 0.002 0.004 0.0098
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0041 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0877 0.0877
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0089 0.0397 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Loa Loa (eye worm) glutaminase 2 0.0296 0.1468 0.3565
Schistosoma mansoni ets-related 0.0239 0.1175 0.1175
Giardia lamblia GTOR 0.0049 0.0188 0.1267
Leishmania major cysteine peptidase A (CPA) 0.003 0.0092 0.1735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Brugia malayi MH2 domain containing protein 0.0022 0.0052 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0087 0.0242
Plasmodium falciparum importin beta, putative 0.0065 0.0273 0.7323
Brugia malayi Fli-1 protein 0.0239 0.1175 0.2852
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0139 0.0967
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0122 0.0122
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0098
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0048 0.0184 0.0447
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0184 0.3365
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.001 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Brugia malayi bHLH-PAS transcription factor 0.004 0.0146 0.0354
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Brugia malayi hypothetical protein 0.017 0.0815 0.1978
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.004 0.004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0088 0.1501
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0129 0.0129
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0048 0.0184 0.4639
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.001 0.0027
Echinococcus multilocularis cathepsin L cysteine protease 0.003 0.0092 0.0092
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.002 0.0194
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0139 0.2498
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0108 0.2725
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0021 0.0394
Loa Loa (eye worm) hypothetical protein 0.0068 0.0287 0.0696
Echinococcus multilocularis axis inhibition protein axin 0.0081 0.0354 0.0354
Brugia malayi hypothetical protein 0.0081 0.0354 0.0858
Loa Loa (eye worm) cysteine protease 0.003 0.0092 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Loa Loa (eye worm) inositol-1 0.0033 0.0108 0.0263
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0058 0.0141
Toxoplasma gondii HEAT repeat-containing protein 0.0065 0.0273 0.6878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.01 0.0278
Loa Loa (eye worm) beta-lactamase 0.0039 0.0139 0.0338
Brugia malayi Inositol-1 0.0033 0.0108 0.0263
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0053 0.0209 0.0583
Loa Loa (eye worm) hypothetical protein 0.0065 0.0273 0.0663
Plasmodium falciparum cysteine proteinase falcipain 1 0.0015 0.0016 0.0437
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0081 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Echinococcus granulosus Smad4 0.0022 0.0052 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0877 0.0877
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.0932 0.7516
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0099
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0088 0.0213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0099 0.0099
Leishmania major trypanothione reductase 0.0084 0.0373 0.7063
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0001
Echinococcus granulosus importin subunit beta 1 0.0065 0.0273 0.0273
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0188 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Leishmania major protein kinase, putative 0.0016 0.002 0.0377
Echinococcus granulosus neuropeptide receptor A26 0.052 0.2624 0.2624
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0122 0.0341
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0099 0.0239
Echinococcus multilocularis dna polymerase kappa 0.002 0.0041 0.0041
Loa Loa (eye worm) glutathione reductase 0.0084 0.0373 0.0905
Echinococcus multilocularis cathepsin l cysteine peptidase 0.003 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0139 0.2498
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0214 0.1043 1
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0364 0.0364
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0016 0.004
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0188 0.3567
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0141
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0104 0.0104
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.001 0.0027
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0188 0.0188
Schistosoma mansoni smad 0.0022 0.0052 0.0052
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0139 0.1252
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0052 0.0126
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.0932 0.7516
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0344 0.0836
Leishmania major DNA polymerase eta, putative 0.002 0.0041 0.0768
Trypanosoma cruzi importin beta-1 subunit, putative 0.0053 0.0209 0.3851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0151 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.004 0.0112
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0129 0.2449
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0303 0.5743
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0088 0.1659
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0016 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0092 0.1578
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0033 0.0108 0.0896
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0122 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0085 0.0238
Leishmania major hypothetical protein, conserved 0.0039 0.0139 0.2638
Plasmodium falciparum glutathione reductase 0.0084 0.0373 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0058 0.048
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0728 0.3702 0.8987
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.001 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0104 0.0104
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0099 0.0099
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0028 0.0028
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0188 0.3567
Echinococcus multilocularis Smad4 0.0022 0.0052 0.0052
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0016 0.0135
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0088 0.0419
Echinococcus granulosus axis inhibition protein axin 0.0081 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0141
Trypanosoma cruzi cruzipain precursor, putative 0.0114 0.0528 1
Plasmodium falciparum glutathione reductase 0.0029 0.0088 0.2349
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.0092 0.0092
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0058 0.0213
Trypanosoma brucei trypanothione reductase 0.0084 0.0373 0.7063
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0081 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Schistosoma mansoni importin beta-1 0.0065 0.0273 0.0273
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0058 0.0213
Echinococcus multilocularis geminin 0.0673 0.3414 0.3414
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0139 0.0967
Echinococcus multilocularis cathepsin L 0.0015 0.0016 0.0016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.1232 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0088 0.1659
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0098
Onchocerca volvulus 0.0024 0.0058 0.0134
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0139 0.0967
Brugia malayi PAS domain containing protein 0.0055 0.0219 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Brugia malayi A-kinase anchor protein 10, precursor 0.0081 0.0354 0.0858
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0129 0.0314
Brugia malayi MH1 domain containing protein 0.0022 0.0052 0.0126
Onchocerca volvulus Huntingtin homolog 0.0138 0.0649 0.1784
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0058 0.0465
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0122 0.0701
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0139 0.0967
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0016 0.0016
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0303 0.0303
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0139 0.0338
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0088 0.2206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0092 0.0222
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0108 0.0301
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0528 1
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.001 0.0027
Brugia malayi hypothetical protein 0.0198 0.096 0.233
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0912 0.465 0.465
Brugia malayi glutaminase DH11.1 0.0296 0.1468 0.3565
Echinococcus multilocularis lamin 0.0023 0.0053 0.0053
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0021 0.0212
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0188 0.0188
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0146 0.0146
Brugia malayi TAR-binding protein 0.0069 0.0291 0.0707
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0188 0.0457
Loa Loa (eye worm) glutaminase 0.0296 0.1468 0.3565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0188 0.156
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0108 0.1898
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0139 0.0388
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0728 0.3702 0.8987
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0015 0.0016 0.0124
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.0932 0.7516
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0021 0.0051
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0058 0.1097
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0028 0.0711
Echinococcus multilocularis beta adrenergic receptor kinase 0.0083 0.0364 0.0364
Loa Loa (eye worm) ctsf protein 0.003 0.0092 0.0222
Echinococcus multilocularis GPCR, family 2 0.0031 0.0099 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Plasmodium vivax vivapain-2 0.003 0.0092 0.2307
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0016 0.0016
Leishmania major DNA polymerase kappa, putative 0.002 0.0041 0.0768
Leishmania major cathepsin L-like protease 0.0114 0.0528 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0081 0.0354 0.0354
Schistosoma mansoni ap endonuclease 0.0037 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.003 0.0092 0.0222
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0592
Schistosoma mansoni DNA polymerase eta 0.002 0.0041 0.0041
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0053 0.0129
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Brugia malayi RNA, U transporter 1 0.0185 0.0893 0.2169
Entamoeba histolytica Ran family GTPase 0.0048 0.0184 0.1526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0155
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0058 0.048
Brugia malayi intermediate filament protein 0.0023 0.0053 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0592
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0048 0.0184 0.0447
Brugia malayi Regulator of G protein signaling domain containing protein 0.0081 0.0354 0.0858
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.003 0.009 0.0561
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0122 0.2317
Echinococcus granulosus cysteine protease 0.0015 0.0016 0.0016
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.012 0.0557 0.3675
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0088 0.0419
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0291 0.0707
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0085 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0041 0.0093
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0728 0.3702 0.3702
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0028 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Echinococcus granulosus lamin dm0 0.0023 0.0053 0.0053
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0373 0.9393
Schistosoma mansoni survival motor neuron protein 0.004 0.0145 0.0145
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Mycobacterium tuberculosis Probable oxidoreductase 0.0214 0.1043 0.8434
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0041 0.0041
Loa Loa (eye worm) fli-1 protein 0.0239 0.1175 0.2852
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0081 0.0354 0.0985
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0021 0.0051
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0129 0.0708
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0053 0.0129
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0041 0.0768
Loa Loa (eye worm) hypothetical protein 0.0099 0.0449 0.109
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0041 0.0113
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0088 0.0244
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0041 0.0113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0198 0.096 0.233
Brugia malayi Cathepsin L-like cysteine proteinase 0.002 0.004 0.0098
Echinococcus multilocularis axis inhibition protein axin 0.0081 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Schistosoma mansoni inositol monophosphatase 0.0033 0.0108 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0592
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.0375 0.0375
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0027 0.0729
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0092 0.0222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0291 0.0707
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0058 0.0141
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0122 0.2171
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0021 0.0212
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0021 0.0021
Plasmodium falciparum cysteine proteinase falcipain 2a 0.003 0.0092 0.2456
Entamoeba histolytica hypothetical protein 0.0081 0.0354 0.2931
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.001 0.001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0088 0.1659
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0028 0.0534
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.012 0.0557 0.4418
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0344 0.0344
Plasmodium vivax importin-beta 2, putative 0.0065 0.0273 0.6878
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0139 0.0967
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.004 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0058 0.0213
Schistosoma mansoni hypothetical protein 0.0032 0.0104 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Schistosoma mansoni axis inhibition protein axin 0.0081 0.0354 0.0354
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.001 0.0027
Schistosoma mansoni hypothetical protein 0.0673 0.3414 0.3414
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0139 0.0139
Onchocerca volvulus Cathepsin F homolog 0.003 0.0092 0.0228
Plasmodium falciparum thioredoxin reductase 0.0084 0.0373 1
Onchocerca volvulus 0.003 0.0092 0.0228
Mycobacterium tuberculosis Probable reductase 0.0192 0.0932 0.7516
Loa Loa (eye worm) hypothetical protein 0.0067 0.0285 0.0692
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0041 0.0041
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0129 0.036
Schistosoma mansoni smad1 5 8 and 0.0022 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0122 0.0341
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0088 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Echinococcus granulosus regulator of G protein signaling 3 0.0081 0.0354 0.0354
Entamoeba histolytica hypothetical protein 0.0032 0.0104 0.0859
Onchocerca volvulus 0.003 0.0092 0.0228
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0016 0.0016
Echinococcus granulosus cathepsin L 0.0015 0.0016 0.0016
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0047 0.0115
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0129 0.036
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0129 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0239
Schistosoma mansoni hypothetical protein 0.0673 0.3414 0.3414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0041 0.0151
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0139 0.0139
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0058 0.0213
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0122 0.0122
Schistosoma mansoni lamin 0.0023 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0058 0.0295
Plasmodium falciparum thioredoxin reductase 0.0029 0.0088 0.2349
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0344 0.0344
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0058 0.0213
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0303 0.2321
Brugia malayi PXA domain containing protein 0.0081 0.0354 0.0858
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0246 0.1206 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0088 0.0419
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.038 0.038
Plasmodium vivax SET domain protein, putative 0.0089 0.0397 1
Echinococcus granulosus regulator of G protein signaling 3 0.0081 0.0354 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0273 0.5173
Toxoplasma gondii thioredoxin reductase 0.0084 0.0373 0.9393
Echinococcus granulosus mothers against decapentaplegic 5 0.0022 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0028 0.0068
Loa Loa (eye worm) RNA binding protein 0.0069 0.0291 0.0707
Echinococcus multilocularis regulator of G protein signaling 7 0.0081 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.0375 0.0375
Leishmania major importin beta-1 subunit, putative 0.0053 0.0209 0.3966
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.003 0.009 0.0777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Mycobacterium ulcerans beta-lactamase 0.0039 0.0139 0.0777
Echinococcus multilocularis smad 0.0022 0.0052 0.0052
Schistosoma mansoni z-protein (S1r protein) 0.0081 0.0354 0.0354
Brugia malayi Smad1 0.0022 0.0052 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0048 0.0184 0.3488
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Echinococcus granulosus cathepsin L cysteine proteinase 0.003 0.0092 0.0092
Mycobacterium ulcerans hypothetical protein 0.0024 0.0058 0.0213
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0139 0.0388
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Brugia malayi Thioredoxin reductase 0.0084 0.0373 0.0905
Trichomonas vaginalis ran, putative 0.0048 0.0184 0.0513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0088 0.1501
Onchocerca volvulus Huntingtin homolog 0.0138 0.0649 0.1784
Echinococcus granulosus smad 0.0022 0.0052 0.0052
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0137 0.2595
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0028 0.0711
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0188 0.0188
Brugia malayi MH1 domain containing protein 0.0012 0 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0099 0.0099

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Induction of Bos taurus (bovine) serum albumin degradation after 1 hr by SDS-PAGE analysis ChEMBL. No reference
IZ (functional) = 9 mm Antimicrobial activity against Escherichia coli at 100 ug after 24 hr by cup diffusion technique ChEMBL. No reference
IZ (functional) = 12 mm Antimicrobial activity against Saccharomyces cerevisiae at 100 ug after 24 hr by cup diffusion technique ChEMBL. No reference
MIC (functional) = 10 ug ml-1 Antimicrobial activity against Saccharomyces cerevisiae after 24 hr by CLSI liquid dilution method ChEMBL. No reference
MIC (functional) = 15 ug ml-1 Antimicrobial activity against Escherichia coli after 24 hr by CLSI liquid dilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.