Detailed information for compound 1791728

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 253.256 | Formula: C14H11N3O2
  • H donors: 1 H acceptors: 1 LogP: 1.34 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)c1ccc(nc1)c1ccc(o1)c1ccco1
  • InChi: 1S/C14H11N3O2/c15-14(16)9-3-4-10(17-8-9)11-5-6-13(19-11)12-2-1-7-18-12/h1-8H,(H3,15,16)
  • InChiKey: PMZSCKMLQPLUNU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0139 0.0967
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0201
Loa Loa (eye worm) hypothetical protein 0.0067 0.0285 0.0692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0088 0.1501
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0048 0.0184 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0202
Brugia malayi beta-lactamase family protein 0.0039 0.0139 0.0338
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0058 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0016 0.0045
Loa Loa (eye worm) ctsf protein 0.003 0.0092 0.0222
Leishmania major cysteine peptidase A (CPA) 0.003 0.0092 0.1735
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0033 0.0108 0.4941
Entamoeba histolytica hypothetical protein 0.0032 0.0104 0.0859
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0145
Loa Loa (eye worm) beta-lactamase 0.0039 0.0139 0.0338
Echinococcus multilocularis smad 0.0022 0.0052 0.0052
Leishmania major protein kinase, putative 0.0016 0.002 0.0377
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0099 0.0239
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0088 0.2349
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0139 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0087 0.0242
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0058 0.1097
Brugia malayi Regulator of G protein signaling domain containing protein 0.0081 0.0354 0.0858
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0081 0.0354 0.0985
Schistosoma mansoni z-protein (S1r protein) 0.0081 0.0354 0.0354
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0058 0.0465
Brugia malayi Smad1 0.0022 0.0052 0.0126
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0016 0.0135
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0041 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0058 0.1097
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0139 0.2498
Echinococcus granulosus geminin 0.0673 0.3414 0.3414
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0088 0.2349
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0041 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0041 0.0041
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0028 0.0711
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.004 0.0112
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0139 0.0338
Brugia malayi Cathepsin L-like cysteine proteinase 0.002 0.004 0.0098
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0139 0.0777
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0021 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0202
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0053 0.0209 0.0583
Loa Loa (eye worm) cysteine protease 0.003 0.0092 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Echinococcus multilocularis musashi 0.0023 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0188 0.0524
Loa Loa (eye worm) glutathione reductase 0.0084 0.0373 0.0905
Echinococcus granulosus regulator of G protein signaling 3 0.0081 0.0354 0.0354
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Schistosoma mansoni lamin 0.0023 0.0053 0.0053
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0016 0.0124
Echinococcus granulosus lamin 0.0023 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0099
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0139 0.0338
Plasmodium vivax vivapain-3 0.0015 0.0016 0.041
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Echinococcus granulosus neuropeptide receptor A26 0.052 0.2624 0.2624
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0528 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0087 0.0242
Brugia malayi bHLH-PAS transcription factor 0.004 0.0146 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0124 0.3117
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0047 0.0115
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.001 0.0024
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0155
Schistosoma mansoni hypothetical protein 0.0032 0.0104 0.0104
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.001 0.001
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.001 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0912 0.465 0.465
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0027 0.0729
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0108 0.0108
Brugia malayi MH1 domain containing protein 0.0012 0 0.0001
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0016 0.0135
Echinococcus granulosus cysteine protease 0.0015 0.0016 0.0016
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0089 0.0397 0.0397
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0041 0.0768
Giardia lamblia GTOR 0.0049 0.0188 0.1267
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.012 0.0557 0.3675
Mycobacterium ulcerans lipase LipD 0.0039 0.0139 0.0777
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.003 0.009 0.0561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Treponema pallidum fructose-bisphosphate aldolase 0.0246 0.1206 1
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0016 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0016 0.0124
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0141
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0027 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0058 0.0141
Onchocerca volvulus 0.0039 0.0139 0.0361
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.002 0.0194
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0081 0.0354 0.0858
Leishmania major DNA polymerase kappa, putative 0.002 0.0041 0.0768
Onchocerca volvulus Cathepsin L homolog 0.003 0.0092 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0041 0.0093
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0184 0.3365
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0099 0.0239
Plasmodium vivax vivapain-2 0.003 0.0092 0.2307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0122 0.2171
Toxoplasma gondii exonuclease III APE 0.0037 0.0129 0.3257
Echinococcus multilocularis cathepsin L cysteine protease 0.003 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0108 0.2725
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0081 0.0354 0.0354
Onchocerca volvulus 0.005 0.0195 0.0517
Brugia malayi PXA domain containing protein 0.0081 0.0354 0.0858
Schistosoma mansoni axis inhibition protein axin 0.0081 0.0354 0.0354
Mycobacterium ulcerans hypothetical protein 0.0039 0.0139 0.0777
Brugia malayi regulator of G-protein signaling rgs-7 0.0081 0.0354 0.0858
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0373 0.9393
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Brugia malayi TAR-binding protein 0.0069 0.0291 0.0707
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.038 0.038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Echinococcus multilocularis GPCR, family 2 0.0031 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.003 0.0092 0.0222
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.001 0.0187
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0139 0.0388
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0139 0.0967
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0155
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0139 0.0139
Brugia malayi Pre-SET motif family protein 0.0621 0.3146 0.7638
Brugia malayi Ets-domain containing protein 0.0079 0.0344 0.0836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.01 0.0278
Loa Loa (eye worm) hypothetical protein 0.0138 0.0649 0.1575
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0728 0.3702 0.8987
Plasmodium falciparum importin beta, putative 0.0065 0.0273 0.7323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0397 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0188 0.0524
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0088 0.1659
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0028 0.0028
Echinococcus granulosus lamin dm0 0.0023 0.0053 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0528 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0122 0.2317
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0139 0.1252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0201
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0088 0.1659
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0137 0.2595
Onchocerca volvulus 0.0039 0.0139 0.0361
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0014 0.001 0.019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0041 0.0041
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0088 0.1659
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.0932 0.7516
Schistosoma mansoni ap endonuclease 0.0037 0.0129 0.0129
Brugia malayi isocitrate dehydrogenase 0.0018 0.0028 0.0068
Trypanosoma brucei trypanothione reductase 0.0084 0.0373 0.7063
Echinococcus multilocularis cathepsin l cysteine peptidase 0.003 0.0092 0.0092
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0129 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Echinococcus multilocularis cathepsin L cysteine protease 0.003 0.0092 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0058 0.0141
Onchocerca volvulus 0.0023 0.0053 0.0121
Entamoeba histolytica hypothetical protein 0.0032 0.0104 0.0859
Schistosoma mansoni glutaminase 0.0296 0.1468 0.1468
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0016 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0108 0.0301
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Schistosoma mansoni smad 0.0022 0.0052 0.0052
Brugia malayi A-kinase anchor protein 10, precursor 0.0081 0.0354 0.0858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Mycobacterium tuberculosis Conserved protein 0.0039 0.0139 0.0967
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0088 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Onchocerca volvulus 0.0024 0.0058 0.0134
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0108 0.0108
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0273 0.5173
Echinococcus granulosus smad 0.0022 0.0052 0.0052
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0188 0.0188
Giardia lamblia Fructose-bisphosphate aldolase 0.0246 0.1206 1
Plasmodium vivax unspecified product 0.0015 0.0016 0.041
Echinococcus granulosus GTP binding nuclear protein Ran 0.0048 0.0184 0.0184
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0122 0.0122
Onchocerca volvulus Cathepsin F homolog 0.003 0.0092 0.0228
Leishmania major cathepsin L-like protease 0.0114 0.0528 1
Echinococcus multilocularis Smad4 0.0022 0.0052 0.0052
Echinococcus granulosus dna polymerase eta 0.002 0.0041 0.0041
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0016 0.0124
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0088 0.0419
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0028 0.0354
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0016 0.004
Echinococcus multilocularis regulator of G protein signaling 7 0.0081 0.0354 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0028 0.005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0099 0.0239
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0129 0.0708
Loa Loa (eye worm) hypothetical protein 0.0065 0.0273 0.0663
Onchocerca volvulus 0.002 0.004 0.0085
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.002 0.0194
Leishmania major importin beta-1 subunit, putative 0.0053 0.0209 0.3966
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0188 0.3567
Schistosoma mansoni survival motor neuron protein 0.004 0.0145 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0155
Plasmodium vivax SET domain protein, putative 0.0089 0.0397 1
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0188 0.0188
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0303 0.0303
Mycobacterium leprae Probable lipase LipE 0.0039 0.0139 0.1252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0085 0.0238
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0188 0.156
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0139 0.0967
Trichomonas vaginalis ran, putative 0.0048 0.0184 0.0513
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.0932 0.7516
Plasmodium falciparum cysteine proteinase falcipain 2b 0.003 0.0092 0.2456
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Trypanosoma cruzi importin beta-1 subunit, putative 0.0053 0.0209 0.3851
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.1232 1
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0098
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.0932 0.7516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.0885 0.2149
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0592
Schistosoma mansoni intermediate filament proteins 0.0023 0.0053 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.012 0.0557 0.5295
Brugia malayi hypothetical protein 0.0081 0.0354 0.0858
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0303 0.5743
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0041 0.0151
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0303 0.1914
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0188 0.0188
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0088 0.0244
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0473
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0129 0.0761
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0592
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0108 0.1898
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0303 0.2321
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0041 0.0151
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.0375 0.0375
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0397 0.0397
Echinococcus granulosus cathepsin l1 0.002 0.004 0.004
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0092 0.0222
Echinococcus multilocularis snurportin 1 0.0695 0.3529 0.3529
Brugia malayi glutaminase DH11.1 0.0296 0.1468 0.3565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0104 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0092 0.1578
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.001 0.0027
Mycobacterium ulcerans hypothetical protein 0.0024 0.0058 0.0213
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0058 0.0213
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0303 0.0303
Echinococcus multilocularis microtubule associated protein 2 0.1946 1 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.003 0.009 0.0777
Schistosoma mansoni microtubule-associated protein tau 0.1946 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0058 0.0213
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0048 0.0184 0.0447
Schistosoma mansoni smad1 5 8 and 0.0022 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0068 0.0287 0.0287
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0088 0.0088
Brugia malayi Regulator of G protein signaling domain containing protein 0.0081 0.0354 0.0858
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0108 0.205
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0041 0.0041
Echinococcus multilocularis dna polymerase eta 0.002 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0122 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.003 0.0092 0.0255
Plasmodium vivax importin-beta 2, putative 0.0065 0.0273 0.6878
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0364 0.0364
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0139 0.2638
Leishmania major trypanothione reductase 0.0084 0.0373 0.7063
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0028 0.0068
Entamoeba histolytica hypothetical protein 0.0053 0.0209 0.1735
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0373 0.0905
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0088 0.0403
Echinococcus multilocularis geminin 0.0673 0.3414 0.3414
Schistosoma mansoni smad1 5 8 and 0.0022 0.0052 0.0052
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0041 0.0113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0141
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0041 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0098
Onchocerca volvulus 0.0089 0.0397 0.1081
Onchocerca volvulus 0.003 0.0092 0.0228
Echinococcus granulosus tumor protein p63 0.0342 0.1703 0.1703
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0139 0.0388
Echinococcus multilocularis cathepsin L 0.0015 0.0016 0.0016
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.001 0.001
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0303 0.7637
Echinococcus multilocularis Regulator of G protein signaling 20 0.0081 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0673 0.3414 0.3414
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0088 0.1659
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Schistosoma mansoni ran 0.0048 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Trichomonas vaginalis importin beta-1, putative 0.0053 0.0209 0.0583
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0021 0.0394
Trypanosoma cruzi cruzipain precursor, putative 0.0114 0.0528 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0188 0.0457
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0129 0.3257
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0344 0.0344
Entamoeba histolytica hypothetical protein 0.0032 0.0104 0.0859
Echinococcus multilocularis cysteine protease 0.003 0.0092 0.0092
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0184 0.3365
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0291 0.0707
Entamoeba histolytica hypothetical protein 0.0081 0.0354 0.2931
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0129 0.2449
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0088 0.0419
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0041 0.0113
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0041 0.0776
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0449 0.109
Schistosoma mansoni ran 0.0048 0.0184 0.0184
Brugia malayi Importin beta-1 subunit 0.0065 0.0273 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Mycobacterium tuberculosis Conserved protein 0.0039 0.0139 0.0967
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0088 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0027 0.0685
Loa Loa (eye worm) glutaminase 0.0296 0.1468 0.3565
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.0092 0.0092
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0188 0.0457
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.0375 0.0375
Entamoeba histolytica cysteine proteinase 2 0.0015 0.0016 0.0135
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0728 0.3702 0.3702
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0053 0.0129
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0449 0.109
Leishmania major GTP-binding protein, putative 0.0048 0.0184 0.3488
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.001 0.0027
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0137 0.2454
Echinococcus granulosus TGF beta signal transducer SmadC 0.0022 0.0052 0.0052
Plasmodium falciparum thioredoxin reductase 0.0084 0.0373 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0192 0.0932 0.8925
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0129 0.2306
Echinococcus multilocularis dna polymerase kappa 0.002 0.0041 0.0041
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0053 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0291 0.0291
Entamoeba histolytica hypothetical protein 0.0081 0.0354 0.2931
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0303 0.1914
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0041 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Echinococcus multilocularis expressed protein 0.0081 0.0354 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Brugia malayi MH1 domain containing protein 0.0022 0.0052 0.0126
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0028 0.0534
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0058 0.0213
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0728 0.3702 0.8987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Onchocerca volvulus 0.003 0.0092 0.0228
Leishmania major protein kinase, putative 0.0016 0.002 0.0377
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0058 0.048
Brugia malayi PXA domain containing protein 0.0081 0.0354 0.0858
Onchocerca volvulus 0.004 0.0145 0.0378
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0139 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0122 0.0341
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0041 0.0098
Echinococcus granulosus importin subunit beta 1 0.0065 0.0273 0.0273
Echinococcus granulosus dna polymerase kappa 0.002 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0099
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0041 0.0768
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0129 0.1071
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0246 0.1206 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0129 1
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0291 0.0291
Brugia malayi PAS domain containing protein 0.0055 0.0219 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.003 0.0092 0.0255
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.0932 0.7516
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0015 0.0016 0.0124
Brugia malayi intermediate filament protein 0.0023 0.0053 0.0129
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0058 0.0465
Entamoeba histolytica Ran family GTPase 0.0048 0.0184 0.1526
Toxoplasma gondii ABC1 family protein 0.0039 0.0139 0.3508
Schistosoma mansoni serine/threonine protein kinase 0.0809 0.4119 0.4119
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0122 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0877 0.0877
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0139 0.0967
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0058 0.048
Echinococcus granulosus Smad4 0.0022 0.0052 0.0052
Echinococcus granulosus beta-adrenergic receptor kinase 0.0083 0.0364 0.0364
Loa Loa (eye worm) Smad1 0.0022 0.0052 0.0126
Echinococcus multilocularis tumor protein p63 0.0342 0.1703 0.1703
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0028 0.0757
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0122 0.0122
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0088 0.054
Echinococcus granulosus intermediate filament protein 0.0023 0.0053 0.0053
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0139 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0087 0.0242
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0104 0.0104
Loa Loa (eye worm) transcription factor SMAD2 0.0328 0.1633 0.3964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0122 0.0701
Loa Loa (eye worm) RNA binding protein 0.0069 0.0291 0.0707
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0052 0.0126
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0092 0.0222
Echinococcus granulosus Regulator of G protein signaling 20 0.0081 0.0354 0.0354
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0098
Echinococcus multilocularis neuropeptide s receptor 0.052 0.2624 0.2624
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0089 0.0397 0.0397
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0122 0.1013
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0592
Echinococcus multilocularis regulator of G protein signaling 3 0.0081 0.0354 0.0354
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.0397 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0016 0.0309
Echinococcus multilocularis regulator of G protein signaling 3 0.0081 0.0354 0.0354
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.001 0.0027
Schistosoma mansoni importin beta-1 0.0065 0.0273 0.0273
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0139 0.0388
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0129 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0129 0.0129
Echinococcus multilocularis lamin 0.0023 0.0053 0.0053
Loa Loa (eye worm) fibroinase 0.003 0.0092 0.0222
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0141
Entamoeba histolytica cysteine proteinase, putative 0.002 0.004 0.0333
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.001 0.0027
Brugia malayi Pre-SET motif family protein 0.0089 0.0397 0.0963
Schistosoma mansoni Smad4 0.0022 0.0052 0.0052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0303 0.0303
Echinococcus granulosus regulator of G protein signaling 7 0.0081 0.0354 0.0354
Brugia malayi Fli-1 protein 0.0239 0.1175 0.2852
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0048 0.0184 0.4639
Mycobacterium tuberculosis Probable oxidoreductase 0.0214 0.1043 0.8434
Echinococcus granulosus cathepsin L 0.0015 0.0016 0.0016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0099 0.0099
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.001 0.0027
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0122 0.0122
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0055 0.1051
Brugia malayi hypothetical protein 0.0138 0.0649 0.1575
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0033 0.0108 0.0896
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0041 0.0592
Entamoeba histolytica cysteine proteinase 1, putative 0.0015 0.0016 0.0135
Loa Loa (eye worm) MH2 domain-containing protein 0.0328 0.1633 0.3964
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0028 0.0028
Brugia malayi RNA, U transporter 1 0.0185 0.0893 0.2169
Echinococcus multilocularis neuropeptide receptor A26 0.052 0.2624 0.2624
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0081 0.0354 0.0354
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0099 0.0099
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0592
Plasmodium vivax vivapain-1 0.0015 0.0016 0.041
Schistosoma mansoni hypothetical protein 0.0695 0.3529 0.3529
Loa Loa (eye worm) hypothetical protein 0.0089 0.0397 0.0963
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0344 0.0836
Mycobacterium ulcerans glutaminase 0.0296 0.1468 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0047 0.0115
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0188 0.3445
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0449 0.109
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Schistosoma mansoni hypothetical protein 0.0673 0.3414 0.3414
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0099 0.0099
Mycobacterium ulcerans beta-lactamase 0.0039 0.0139 0.0777
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0108 0.0301
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0219 0.0219
Brugia malayi Thioredoxin reductase 0.0084 0.0373 0.0905
Brugia malayi cathepsin L-like precursor 0.002 0.004 0.0098
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0098
Mycobacterium tuberculosis Conserved protein 0.0039 0.0139 0.0967
Loa Loa (eye worm) nuclear factor I 0.0012 0 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0809 0.4119 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0088 0.0088
Onchocerca volvulus Huntingtin homolog 0.0138 0.0649 0.1784
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0041 0.0768
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0139 0.0388
Brugia malayi MH1 domain containing protein 0.0012 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Brugia malayi MH2 domain containing protein 0.0022 0.0052 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0239
Loa Loa (eye worm) hypothetical protein 0.0198 0.096 0.233
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0081 0.0354 0.0354
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0016 0.0016
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0108 0.0562
Echinococcus granulosus cathepsin l1 0.003 0.0092 0.0092
Echinococcus multilocularis regulator of G protein signaling 7 0.0081 0.0354 0.0354
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0188 0.156
Trichomonas vaginalis glutaminase, putative 0.0296 0.1468 0.4091
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1659
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0021 0.0021
Echinococcus multilocularis lamin dm0 0.0023 0.0053 0.0053
Brugia malayi hypothetical protein 0.0032 0.0104 0.0252
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Loa Loa (eye worm) hypoxia-induced factor 1 0.0169 0.0812 0.197
Schistosoma mansoni single-minded 0.0055 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0016 0.0045
Brugia malayi MH2 domain containing protein 0.0022 0.0052 0.0126
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0021 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0048 0.0184 0.3488
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.002 0.0194
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trypanosoma cruzi major cysteine proteinase, putative 0.009 0.0401 0.7556
Leishmania major hypothetical protein, conserved 0.0039 0.0139 0.2638
Trichomonas vaginalis set domain proteins, putative 0.0706 0.359 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0024
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.002 0.0194
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0021 0.0394
Loa Loa (eye worm) hypothetical protein 0.0099 0.0449 0.109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0877 0.0877
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0108 0.1898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Schistosoma mansoni inositol monophosphatase 0.0033 0.0108 0.0108
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0129 0.0314
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0088 0.1659
Entamoeba histolytica hypothetical protein 0.0081 0.0354 0.2931
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0028 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0139 0.3508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0122 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0151 0.0422
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0041 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0364 0.0364
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0053 0.0209 0.0583
Brugia malayi beta-lactamase family protein 0.0039 0.0139 0.0338
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0297
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0129 0.2449
Echinococcus granulosus neuropeptide s receptor 0.052 0.2624 0.2624
Trypanosoma brucei unspecified product 0.002 0.0041 0.0768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0201
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Brugia malayi hypoxia-induced factor 1 0.0169 0.0812 0.197
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0028 0.0711
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1501
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0122 0.2171
Echinococcus granulosus axis inhibition protein axin 0.0081 0.0354 0.0354
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0016 0.0135
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0129 0.0129
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0058 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0028 0.0354
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0083 0.0364 0.0883
Schistosoma mansoni ap endonuclease 0.0037 0.0129 0.0129
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0139 0.0967
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0092 0.0759
Echinococcus multilocularis importin subunit beta 1 0.0065 0.0273 0.0273
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0021 0.0212
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0122 0.2317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0124
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0809 0.4119 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0021 0.0051
Onchocerca volvulus 0.0039 0.0139 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Plasmodium falciparum cysteine proteinase falcipain 2a 0.003 0.0092 0.2456
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0137 0.2595
Echinococcus multilocularis mothers against decapentaplegic 5 0.0022 0.0052 0.0052
Mycobacterium ulcerans putative regulatory protein 0.004 0.0146 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0004 0.0011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0088 0.2206
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0188 0.3567
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.003 0.0092 0.0222
Schistosoma mansoni axis inhibition protein axin 0.0081 0.0354 0.0354
Schistosoma mansoni inositol monophosphatase 0.0033 0.0108 0.0108
Brugia malayi hypothetical protein 0.0183 0.0885 0.2149
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0122 0.0297
Echinococcus multilocularis axis inhibition protein axin 0.0081 0.0354 0.0354
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0129 0.0314
Onchocerca volvulus 0.004 0.0146 0.0379
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0528 1
Echinococcus granulosus cathepsin L cysteine protease 0.0015 0.0016 0.0016
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0139 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Echinococcus granulosus mothers against decapentaplegic 5 0.0022 0.0052 0.0052
Toxoplasma gondii thioredoxin reductase 0.0084 0.0373 0.9393
Onchocerca volvulus 0.003 0.0092 0.0228
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.001 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0081 0.0354 0.0354
Schistosoma mansoni lamin 0.0023 0.0053 0.0053
Brugia malayi beta-lactamase 0.0039 0.0139 0.0338
Leishmania major cathepsin L-like protease 0.0114 0.0528 1
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0287 0.0696
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0291 0.0707
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0877 0.0877
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0108 0.205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0397 0.0397
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0048 0.0184 0.4639
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.001 0.0027
Plasmodium falciparum glutathione reductase 0.0029 0.0088 0.2349
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0139 0.0139
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0303 0.0303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Onchocerca volvulus 0.003 0.0092 0.0228
Brugia malayi MH2 domain containing protein 0.0328 0.1633 0.3964
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.004 0.0145 0.0352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0098
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0273 0.5173
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0088 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0058 0.048
Schistosoma mansoni ets-related 0.0239 0.1175 0.1175
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0028 0.0534
Loa Loa (eye worm) hypothetical protein 0.0138 0.0649 0.1575
Echinococcus multilocularis regulator of G protein signaling 0.0081 0.0354 0.0354
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0188 0.3567
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0877 0.0877
Schistosoma mansoni DNA polymerase eta 0.002 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.004 0.0112
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0028 0.0028
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0139 0.0967
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0338
Toxoplasma gondii cathepsin CPL 0.003 0.0092 0.2307
Brugia malayi regulator of G-protein signaling egl-10 0.0081 0.0354 0.0858
Leishmania major DNA polymerase eta, putative 0.002 0.0041 0.0768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0058 0.0295
Echinococcus granulosus regulator of G protein signaling 3 0.0081 0.0354 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0345
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0104 0.0476 0.9009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0354 0.0985
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0092 0.0255
Onchocerca volvulus 0.003 0.0092 0.0228
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0048 0.0184 0.0447
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0088 0.2206
Loa Loa (eye worm) fli-1 protein 0.0239 0.1175 0.2852
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0098
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.0932 0.7516
Plasmodium vivax vivapain-2 0.003 0.0092 0.2307
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Brugia malayi hypothetical protein 0.017 0.0815 0.1978
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0058 0.0213
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.0877 0.213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0202
Onchocerca volvulus 0.0023 0.0053 0.0121
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0122 0.0122
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0053 0.0129
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Onchocerca volvulus 0.003 0.0092 0.0228
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.001 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0768
Loa Loa (eye worm) RGS-3 protein 0.0081 0.0354 0.0858
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.0397 0.0397
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0028 0.0534
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0373 0.2896
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0188 0.3445
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0088 0.1659
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0122 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0188 0.0524
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0016 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0129 0.2306
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Echinococcus multilocularis axis inhibition protein axin 0.0081 0.0354 0.0354
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0155
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0092 0.0255
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0373 0.7008
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0058 0.0141
Brugia malayi Inositol-1 0.0033 0.0108 0.0263
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Trichomonas vaginalis esterase, putative 0.0039 0.0139 0.0388
Schistosoma mansoni regulator of G protein signaling 0.0081 0.0354 0.0354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0877 0.0877
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0214 0.1043 0.8434
Loa Loa (eye worm) inositol-1 0.0033 0.0108 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0085 0.0238
Onchocerca volvulus 0.003 0.0092 0.0228
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0129 0.036
Onchocerca volvulus Huntingtin homolog 0.0138 0.0649 0.1784
Brugia malayi MH1 domain containing protein 0.0022 0.0052 0.0126
Onchocerca volvulus 0.0706 0.359 1
Schistosoma mansoni gabp alpha 0.0079 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.017 0.0815 0.1978
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.0092 0.0092
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0021 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.1206 0.3361
Entamoeba histolytica cysteine protease, putative 0.0015 0.0016 0.0135
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0041 0.0768
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.004 0.004
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0122 0.0122
Plasmodium falciparum glutathione reductase 0.0084 0.0373 1
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0028 0.0068
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0058 0.1097
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0021 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0877 0.0877
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.001 0.0027
Mycobacterium tuberculosis Probable reductase 0.0192 0.0932 0.7516
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0303 0.1914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0137 0.0381
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0022 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0021 0.0058
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0048 0.0184 0.1231
Echinococcus granulosus tar DNA binding protein 0.0069 0.0291 0.0291
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0041 0.0768
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0021 0.0394
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0695 0.3529 0.8568
Echinococcus granulosus cathepsin L cysteine proteinase 0.003 0.0092 0.0092
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0129 0.3467
Echinococcus granulosus histone lysine methyltransferase setb 0.0089 0.0397 0.0397
Echinococcus granulosus survival motor neuron protein 1 0.0198 0.096 0.096
Brugia malayi Ets-domain containing protein 0.0079 0.0344 0.0836
Echinococcus multilocularis cathepsin l cysteine peptidase 0.003 0.0092 0.0092
Trypanosoma cruzi cysteine protease, putative 0.0015 0.0016 0.0124
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0081 0.0354 0.0354
Onchocerca volvulus 0.017 0.0815 0.2248
Brugia malayi hypothetical protein 0.0198 0.096 0.233
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.012 0.0557 0.4418
Loa Loa (eye worm) PXA domain-containing protein 0.0081 0.0354 0.0858
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0195 0.0195
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0246 0.1206 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0105 0.0293
Echinococcus granulosus regulator of G protein signaling 7 0.0081 0.0354 0.0354
Onchocerca volvulus Cathepsin L homolog 0.003 0.0092 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Loa Loa (eye worm) glutaminase 2 0.0296 0.1468 0.3565
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0048 0.0184 0.4939
Entamoeba histolytica hypothetical protein 0.0032 0.0104 0.0859
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0728 0.3702 0.3702
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0092 0.0759
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0122 0.0122
Echinococcus multilocularis survival motor neuron protein 1 0.0198 0.096 0.096
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0021 0.0051
Echinococcus multilocularis beta adrenergic receptor kinase 0.0083 0.0364 0.0364
Entamoeba histolytica cysteine protease, putative 0.003 0.0092 0.0759
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0129
Echinococcus granulosus axis inhibition protein axin 0.0081 0.0354 0.0354
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0058 0.0213
Echinococcus granulosus cathepsin l cysteine peptidase 0.003 0.0092 0.0092
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0027 0.2229
Brugia malayi RNA binding protein 0.0069 0.0291 0.0707
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0028 0.0711
Toxoplasma gondii HEAT repeat-containing protein 0.0065 0.0273 0.6878
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0058 0.0213
Echinococcus multilocularis cysteine protease 0.003 0.0092 0.0092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0621 0.3146 0.7638
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0088 0.2206
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0214 0.1043 0.8434
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0088 0.0419
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0728 0.3702 0.8987
Leishmania major cathepsin L-like protease 0.003 0.0092 0.1735
Plasmodium falciparum cysteine proteinase falcipain 3 0.003 0.0092 0.2456
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0129 0.036
Loa Loa (eye worm) hypothetical protein 0.0068 0.0287 0.0696
Echinococcus granulosus single minded 2 0.004 0.0146 0.0146
Plasmodium vivax glutathione reductase, putative 0.0084 0.0373 0.9393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0188 0.3567
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.0877 0.213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0877 0.0877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0016 0.0309
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0028 0.0028
Brugia malayi hypothetical protein 0.0081 0.0354 0.0858
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0052 0.0126
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0088 0.1501
Plasmodium falciparum thioredoxin reductase 0.0029 0.0088 0.2349
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0066
Brugia malayi glutathione reductase 0.0084 0.0373 0.0905
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0146 0.0146
Schistosoma mansoni smad1 5 8 and 0.0022 0.0052 0.0052
Echinococcus granulosus snurportin 1 0.0695 0.3529 0.3529
Echinococcus granulosus expressed protein 0.0081 0.0354 0.0354
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0291 0.0707
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0108 0.0301
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0858
Plasmodium falciparum cysteine proteinase falcipain 1 0.0015 0.0016 0.0437
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0139 0.2498
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0088 0.1501
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0214 0.1043 1
Brugia malayi Cathepsin L-like precursor 0.003 0.0092 0.0222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0528 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0099 0.0099
Echinococcus granulosus GPCR family 2 0.0031 0.0099 0.0099
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0022 0.0052 0.0052
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0088 0.1659
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0088 0.2206
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0344 0.0344
Leishmania major cathepsin L-like protease 0.0114 0.0528 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0139 0.0967

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Induction of Bos taurus (bovine) serum albumin degradation after 1 hr by SDS-PAGE analysis ChEMBL. No reference
IZ (functional) = 9 mm Antimicrobial activity against Escherichia coli at 100 ug after 24 hr by cup diffusion technique ChEMBL. No reference
IZ (functional) = 12 mm Antimicrobial activity against Saccharomyces cerevisiae at 100 ug after 24 hr by cup diffusion technique ChEMBL. No reference
MIC (functional) = 10 ug ml-1 Antimicrobial activity against Saccharomyces cerevisiae after 24 hr by CLSI liquid dilution method ChEMBL. No reference
MIC (functional) = 15 ug ml-1 Antimicrobial activity against Escherichia coli after 24 hr by CLSI liquid dilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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