Detailed information for compound 1816329

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 240.339 | Formula: C14H24O3
  • H donors: 0 H acceptors: 1 LogP: 2.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)O[C@@H]1C[C@@]2(O[C@]1(C)CC2)C(C)C
  • InChi: 1S/C14H24O3/c1-5-6-12(15)16-11-9-14(10(2)3)8-7-13(11,4)17-14/h10-11H,5-9H2,1-4H3/t11-,13-,14-/m1/s1
  • InChiKey: ZKPFHYZAJWKIKY-MRVWCRGKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dnaJ subfamily B 0.0856 0.9774 0.9774
Schistosoma mansoni beta-catenin 0.0201 0.2173 0.2223
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0165 0.174
Brugia malayi TAR-binding protein 0.0065 0.0598 0.1899
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0072 0.0224
Loa Loa (eye worm) hypothetical protein 0.0071 0.0665 0.211
Onchocerca volvulus 0.0152 0.1603 0.601
Loa Loa (eye worm) hypothetical protein 0.0152 0.1603 0.5091
Onchocerca volvulus 0.0046 0.0377 0.1413
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0276 0.0282
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0397 0.0405
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0289 0.3196 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0452 0.0462
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0943 0.2995
Entamoeba histolytica hypothetical protein 0.0037 0.0276 0.2924
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.0791 0.0808
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0165 0.0521
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0583 0.1824
Leishmania major DNA polymerase eta, putative 0.0032 0.0217 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0072 0.0087
Loa Loa (eye worm) MBCTL1 0.0053 0.0452 0.1433
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0134 0.14 0.1432
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0165 0.0201
Schistosoma mansoni hypothetical protein 0.0345 0.3844 0.3932
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0165 0.0513
Loa Loa (eye worm) hypothetical protein 0.0112 0.1144 0.3632
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0397 0.0396
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2205 0.7003
Mycobacterium ulcerans lipase LipD 0.0112 0.1144 0.3632
Echinococcus multilocularis expressed protein 0.0018 0.0052 0.0051
Schistosoma mansoni glutaminase 0.0285 0.3149 0.3221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.02 0.0204
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0665 0.211
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0195 0.2107 0.2155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.2011 0.2057
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0028 0.0165 0.0521
Toxoplasma gondii ABC1 family protein 0.0112 0.1144 0.417
Mycobacterium ulcerans glutaminase 0.0285 0.3149 1
Onchocerca volvulus 0.0112 0.1144 0.4288
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0165 0.0521
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0165 0.0521
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.2011 0.6384
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0165 0.0521
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0943 0.2995
Entamoeba histolytica hypothetical protein 0.0037 0.0276 0.2924
Mycobacterium leprae Probable lipase LipE 0.0112 0.1144 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0072 0.0224
Loa Loa (eye worm) hypothetical protein 0.0112 0.1144 0.3632
Mycobacterium ulcerans hypothetical protein 0.0112 0.1144 0.3632
Loa Loa (eye worm) HMG box family protein 0.0134 0.14 0.4445
Entamoeba histolytica hypothetical protein 0.0037 0.0276 0.2924
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0082 0.0257
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0583 0.1852
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0598 0.0612
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0165 0.0513
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0165 0.0521
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0583 0.6182
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0001 0.0002
Mycobacterium leprae conserved hypothetical protein 0.0112 0.1144 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0072 0.0222
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0117 0.0117
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0376 0.1193
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0313 0.0978
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.2011 0.2057
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0165 0.0513
Schistosoma mansoni ets-related 0.0248 0.2724 0.2787
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0598 0.0612
Echinococcus granulosus dnaJ subfamily B 0.0856 0.9774 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0165 0.0521
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0377 0.0386
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.012 0.0146
Plasmodium vivax SET domain protein, putative 0.0031 0.02 0.036
Loa Loa (eye worm) hypothetical protein 0.0053 0.0452 0.1433
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0201 0.2173 0.6902
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0165 0.0521
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0313 0.0977
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0243 0.2667 0.2729
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0377 0.1197
Onchocerca volvulus 0.0028 0.0165 0.0615
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0072 0.0226
Onchocerca volvulus 0.0232 0.2529 0.9481
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0165 0.0515
Brugia malayi Fli-1 protein 0.0248 0.2724 0.8652
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Leishmania major mitochondrial DNA polymerase beta 0.0289 0.3196 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0583 0.0583
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.2 0.7497
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1144 0.3632
Echinococcus multilocularis protein pangolin J 0.0134 0.14 0.14
Onchocerca volvulus 0.0112 0.1144 0.4288
Schistosoma mansoni cpg binding protein 0.0097 0.0964 0.0986
Schistosoma mansoni pangolin 0.0134 0.14 0.1432
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0257
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0165 0.0201
Schistosoma mansoni ferritin 0.0018 0.0052 0.0053
Trichomonas vaginalis ferritin, putative 0.0018 0.0052 0.0163
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0257
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0052 0.0163
Loa Loa (eye worm) hypothetical protein 0.0186 0.2 0.635
Echinococcus granulosus tar DNA binding protein 0.0065 0.0598 0.0612
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0165 0.0521
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1144 0.117
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0117 0.0119
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0014 0.0001 0.0002
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0117 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0257
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0165 0.1435
Brugia malayi Pre-SET motif family protein 0.0204 0.2205 0.7003
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0583 0.1824
Mycobacterium ulcerans hypothetical protein 0.0095 0.0943 0.2995
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0583 0.1826
Schistosoma mansoni hypothetical protein 0.0856 0.9774 1
Loa Loa (eye worm) HMP-2 protein 0.0201 0.2173 0.6902
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0082 0.0257
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0257
Loa Loa (eye worm) hypothetical protein 0.0071 0.0665 0.211
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0071 0.0665 0.5
Mycobacterium tuberculosis Conserved protein 0.0112 0.1144 0.14
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1144 0.3579
Echinococcus granulosus dna polymerase kappa 0.002 0.0072 0.0073
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1598 0.5073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0165 0.0521
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.1144 0.3632
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0452 0.1433
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0397 0.1258
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0164 0.0168
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0447 0.14
Schistosoma mansoni cpg binding protein 0.0097 0.0964 0.0986
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0598 0.0612
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0182 0.0186
Trichomonas vaginalis esterase, putative 0.0112 0.1144 0.3632
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0377 0.0386
Schistosoma mansoni hypothetical protein 0.0048 0.0397 0.0405
Brugia malayi beta-lactamase family protein 0.0112 0.1144 0.3632
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0377 0.0386
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.2743 0.2806
Mycobacterium tuberculosis Conserved protein 0.0112 0.1144 0.14
Loa Loa (eye worm) hypothetical protein 0.0071 0.0665 0.211
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0447 0.1398
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0165 0.0515
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0377 0.0386
Plasmodium falciparum acyl-CoA synthetase 0.0071 0.0665 1
Brugia malayi hypothetical protein 0.0037 0.0276 0.0876
Brugia malayi beta-lactamase family protein 0.0112 0.1144 0.3632
Brugia malayi beta-lactamase 0.0112 0.1144 0.3632
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0052 0.0063
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0583 0.1824
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0165 0.0201
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0182 0.0181
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.025 0.2743 0.3358
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0217 0.0678
Mycobacterium ulcerans beta-lactamase 0.0112 0.1144 0.3632
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0583 0.0596
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0165 0.0513
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0137 0.1429 0.4469
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0243 0.2667 1
Echinococcus multilocularis geminin 0.0345 0.3844 0.3843
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.1193
Schistosoma mansoni ferritin 0.0018 0.0052 0.0053
Echinococcus multilocularis dna polymerase eta 0.0046 0.0376 0.0376
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0903 0.2867
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1144 0.117
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0447 0.5653
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0014 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0257
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0447 0.1629
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0943 0.8246
Onchocerca volvulus 0.0091 0.0903 0.3385
Schistosoma mansoni apoferritin-2 0.0018 0.0052 0.0053
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0165 0.0164
Echinococcus granulosus pangolin 0.0134 0.14 0.1432
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.0633
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0095 0.0943 0.2995
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0598 0.1899
Brugia malayi hypothetical protein 0.0052 0.0447 0.1419
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0165 0.0521
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0397 0.1258
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Plasmodium vivax acyl-CoA synthetase, putative 0.0071 0.0665 0.5106
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0397 0.0405
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0598 0.1899
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0943 0.2995
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0165 0.1435
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.2011 0.201
Schistosoma mansoni hypothetical protein 0.0281 0.3103 0.3174
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.1144 0.14
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0014 0.0001 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0174 0.1866 0.6802
Trichomonas vaginalis CAMK family protein kinase 0.0243 0.2667 0.847
Schistosoma mansoni hypothetical protein 0.0048 0.0397 0.0405
Mycobacterium tuberculosis Conserved hypothetical protein 0.0152 0.1608 0.1969
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1598 0.5073
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0113 0.0112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0943 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0257
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0072 0.0222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.062 0.0758
Brugia malayi CXXC zinc finger family protein 0.0091 0.0903 0.2867
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0052 1
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1144 0.3632
Echinococcus granulosus geminin 0.0345 0.3844 0.3932
Loa Loa (eye worm) glutaminase 2 0.0285 0.3149 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0137 0.1429 0.447
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0134 0.14 0.14
Loa Loa (eye worm) hypothetical protein 0.0112 0.1144 0.3632
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0165 0.0521
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0165 0.1435
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0165 0.0521
Loa Loa (eye worm) hypothetical protein 0.0112 0.1144 0.3632
Loa Loa (eye worm) glutaminase 0.0285 0.3149 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0052 0.0163
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0243 0.2667 0.2729
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0165 0.0168
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0072 0.0073
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0071 0.0665 0.0813
Brugia malayi Ets-domain containing protein 0.0082 0.0791 0.251
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1144 0.3632
Entamoeba histolytica hypothetical protein 0.0037 0.0276 0.2924
Brugia malayi Ets-domain containing protein 0.0082 0.0791 0.251
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0165 0.0521
Leishmania major hypothetical protein, conserved 0.0052 0.0447 0.1398
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0598 0.0612
Loa Loa (eye worm) TTK protein kinase 0.0243 0.2667 0.847
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0276 0.0282
Loa Loa (eye worm) hypothetical protein 0.0149 0.1569 0.4983
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1144 0.3632
Toxoplasma gondii aldehyde dehydrogenase 0.025 0.2743 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.02 0.0727
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.1144 0.14
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0452 0.0462
Trichomonas vaginalis CAMK family protein kinase 0.0243 0.2667 0.847
Brugia malayi hypothetical protein 0.0152 0.1603 0.5091
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.1144 0.1144
Loa Loa (eye worm) hypothetical protein 0.0151 0.1598 0.5073
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0165 0.0521
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1598 0.5073
Onchocerca volvulus Cirhin homolog 0.02 0.2158 0.809
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0165 0.0521
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0289 0.3196 1
Brugia malayi Protein kinase domain containing protein 0.0243 0.2667 0.847
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.1144 0.358
Brugia malayi mbt repeat family protein 0.0046 0.0377 0.1197
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0257
Loa Loa (eye worm) hypothetical protein 0.0046 0.0377 0.1197
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0095 0.0943 0.2995
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0072 0.0226
Schistosoma mansoni hypothetical protein 0.0048 0.0397 0.0405
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0137 0.1429 0.4469
Echinococcus multilocularis cpg binding protein 0.0097 0.0964 0.0963
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.02 0.0204
Echinococcus granulosus beta catenin 0.0201 0.2173 0.2223
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.1144 0.14
Echinococcus granulosus expressed protein 0.0018 0.0052 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0165 0.0521
Echinococcus multilocularis GPCR, family 2 0.0048 0.0397 0.0396
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0165 0.0598
Loa Loa (eye worm) hypothetical protein 0.007 0.0653 0.2072
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0165 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0257
Schistosoma mansoni hypothetical protein 0.0023 0.0113 0.0115
Loa Loa (eye worm) beta-lactamase 0.0112 0.1144 0.3632
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0447 0.2886
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0271 0.0276
Schistosoma mansoni hypothetical protein 0.0037 0.0276 0.0282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.02 0.0204
Echinococcus granulosus muscleblind protein 0.0149 0.1569 0.1605
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0243 0.2667 0.2667
Echinococcus multilocularis muscleblind protein 0.0149 0.1569 0.1569
Loa Loa (eye worm) oxidoreductase 0.0028 0.0165 0.0521
Loa Loa (eye worm) hypothetical protein 0.0052 0.0447 0.1419
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0447 0.5653
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0217 0.079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.02 0.0199
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.0791 0.251
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.0791 0.079
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0943 0.2995
Loa Loa (eye worm) hypothetical protein 0.0071 0.0665 0.211
Schistosoma mansoni ferritin light chain 0.0018 0.0052 0.0053
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.1144 0.117
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0165 0.0513
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.062 0.0758
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0943 0.2951
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0072 0.0226
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0376 0.1177
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0416 0.13
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0257
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0072 0.0226
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0165 0.0513
Schistosoma mansoni hypothetical protein 0.0048 0.0397 0.0405
Entamoeba histolytica acyl-coA synthetase, putative 0.0095 0.0943 1
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1569 0.1569
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0072 0.0226
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1144 0.3632
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0178 0.0563
Giardia lamblia DINP protein human, muc B family 0.002 0.0072 0.0267
Onchocerca volvulus 0.0028 0.0165 0.0615
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0377 0.0377
Onchocerca volvulus 0.0112 0.1144 0.4288
Loa Loa (eye worm) hypothetical protein 0.0071 0.0665 0.211
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0006 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.1144 0.14
Toxoplasma gondii hypothetical protein 0.0047 0.0382 0.1391
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0257
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0377 0.0386
Schistosoma mansoni cpg binding protein 0.0091 0.0903 0.0924
Onchocerca volvulus 0.0028 0.0165 0.0615
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0072 0.0222
Onchocerca volvulus 0.0028 0.0165 0.0615
Loa Loa (eye worm) hypothetical protein 0.0149 0.1569 0.4983
Echinococcus granulosus hypothetical protein 0.0622 0.7064 0.7227
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.2743 0.871
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0072 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0165 0.0598
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0943 0.8246
Loa Loa (eye worm) hypothetical protein 0.0095 0.0943 0.2995
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0257
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0452 0.0451
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.02 0.0204
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0289 0.3196 1
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.1144 0.3632
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0072 0.0224
Loa Loa (eye worm) RNA binding protein 0.0065 0.0598 0.1899
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0165 0.0513
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0447 0.1398
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Loa Loa (eye worm) hypothetical protein 0.0103 0.1042 0.3307
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.2011 0.2057
Mycobacterium tuberculosis Conserved protein 0.0112 0.1144 0.14
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.2011 0.201
Echinococcus granulosus ferritin 0.0018 0.0052 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0943 0.2995
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0165 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0165 0.0521
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0113 0.0115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0257
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0117 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0095 0.0943 0.2995
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0095 0.0943 0.2995
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0943 0.2951
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.2743 0.871
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0072 0.0754
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0165 0.0598
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0165 0.0201
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.1144 0.14
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.062 0.0758
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0165 0.0521
Leishmania major DNA polymerase kappa, putative 0.002 0.0072 0.0222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0943 0.1155
Plasmodium vivax hypothetical protein, conserved 0.0112 0.1144 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0165 0.0201
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0452 0.0462
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0165 0.0521
Schistosoma mansoni hypothetical protein 0.0489 0.5519 0.5647
Onchocerca volvulus 0.0031 0.02 0.0748
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0583 0.1852
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0717 0.8167 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Schistosoma mansoni ferritin 0.0018 0.0052 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0257
Schistosoma mansoni hypothetical protein 0.0345 0.3844 0.3932
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0165 0.0521
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0165 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1144 0.3579
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0072 0.0222
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.1144 0.3632
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.1144 0.14
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0165 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0165 0.0521
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0052 0.045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.2011 0.2057
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0943 1
Schistosoma mansoni DNA polymerase eta 0.0046 0.0376 0.0384
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0072 0.0222
Trypanosoma brucei unspecified product 0.002 0.0072 0.0224
Loa Loa (eye worm) fli-1 protein 0.0248 0.2724 0.8652
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0072 0.0087
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0313 0.0977
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.1144 0.3632
Loa Loa (eye worm) hypothetical protein 0.0112 0.1144 0.3632
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.025 0.2743 0.2743
Brugia malayi RNA binding protein 0.0065 0.0598 0.1899
Schistosoma mansoni ferritin light chain 0.0018 0.0052 0.0053
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.1955 0.2
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0943 0.2995
Leishmania major hypothetical protein, conserved 0.0112 0.1144 0.3579
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.2743 0.2806
Schistosoma mansoni ferritin 0.0018 0.0052 0.0053
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0598 0.1899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.2011 0.2057
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0165 0.0201
Loa Loa (eye worm) hypothetical protein 0.0048 0.0397 0.1258
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0165 0.0521
Brugia malayi hypothetical protein 0.0034 0.0232 0.0736
Brugia malayi glutaminase DH11.1 0.0285 0.3149 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.1144 0.3632
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.02 0.0199
Giardia lamblia Kinase, TTK 0.0243 0.2667 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0165 0.0521
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0072 0.0071
Brugia malayi Pre-SET motif family protein 0.0031 0.02 0.0633
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0165 0.0521
Echinococcus granulosus GPCR family 2 0.0048 0.0397 0.0405
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0165 0.0201
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0943 0.2951
Schistosoma mansoni gabp alpha 0.0082 0.0791 0.0808
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0165 0.0521
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0117 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.02 0.0204
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0397 0.1258
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0598 0.0612
Onchocerca volvulus 0.0095 0.0943 0.3536
Trichomonas vaginalis glutaminase, putative 0.0285 0.3149 1
Brugia malayi Muscleblind-like protein 0.0149 0.1569 0.4983
Echinococcus multilocularis ferritin 0.0018 0.0052 0.0051
Brugia malayi N-terminal motif family protein 0.0186 0.2 0.635
Echinococcus multilocularis dna polymerase kappa 0.002 0.0072 0.0071
Trichomonas vaginalis helicase, putative 0.0021 0.0082 0.0257
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0943 0.2995
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.1144 0.14
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0377 0.1413
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0397 0.0396
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.025 0.2743 0.8582
Mycobacterium ulcerans hypothetical protein 0.0152 0.1608 0.5106
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0313 0.0977
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0271 0.027
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.025 0.2743 0.2806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0257
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0052 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0072 0.0073
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0014 0.0001 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.2743 0.871
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1042 0.3307
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0052 0.0063
Leishmania major DNA polymerase eta, putative 0.0046 0.0376 0.1176
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0182 0.0576
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2529 0.8031
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0165 0.0521
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.2011 0.6384
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0095 0.0943 0.1155
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0376 0.1176
Echinococcus multilocularis beta catenin 0.0201 0.2173 0.2173
Brugia malayi HMG box family protein 0.0134 0.14 0.4445
Echinococcus granulosus cpg binding protein 0.0097 0.0964 0.0986
Schistosoma mansoni apoferritin-2 0.0018 0.0052 0.0053
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0072 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0072 0.0224
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0598 0.0598
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0165 0.0521
Loa Loa (eye worm) hypothetical protein 0.0095 0.0943 0.2995
Brugia malayi mbt repeat family protein 0.0046 0.0377 0.1197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.062 0.0758
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0583 0.0596
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0165 0.0201
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.1955 0.1955
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0165 0.0168
Echinococcus granulosus dna polymerase eta 0.0046 0.0376 0.0384
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0452 0.0451
Schistosoma mansoni hypothetical protein 0.0103 0.1042 0.1065

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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