Detailed information for compound 1816334

Basic information

Technical information
  • TDR Targets ID: 1816334
  • Name: (E)-N-cyclopentyl-3-phenylprop-2-enamide
  • MW: 215.291 | Formula: C14H17NO
  • H donors: 1 H acceptors: 1 LogP: 2.89 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCCC1)/C=C/c1ccccc1
  • InChi: 1S/C14H17NO/c16-14(15-13-8-4-5-9-13)11-10-12-6-2-1-3-7-12/h1-3,6-7,10-11,13H,4-5,8-9H2,(H,15,16)/b11-10+
  • InChiKey: PHBMWWQRXLSNDW-ZHACJKMWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclopentyl-3-phenylprop-2-enamide
  • (E)-N-cyclopentyl-3-phenyl-prop-2-enamide
  • N-cyclopentyl-3-phenyl-prop-2-enamide
  • (E)-N-cyclopentyl-3-phenyl-acrylamide
  • N-cyclopentyl-3-phenyl-acrylamide
  • AO-548/40085355
  • ZINC01016996

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0171 0.032 0.092
Plasmodium falciparum ataxin-2 like protein, putative 0.0091 0.0155 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0007 0.0395
Loa Loa (eye worm) hypothetical protein 0.0063 0.0097 0.0278
Echinococcus multilocularis survival motor neuron protein 1 0.0179 0.0336 0.0336
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0031 0.0031 0.0089
Echinococcus multilocularis cpg binding protein 0.0029 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0029 0.0027 0.0079
Echinococcus multilocularis pyruvate kinase 0.003 0.003 0.003
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0054 0.008 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0026 0.0073
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0006 0.0393
Toxoplasma gondii pyruvate kinase PyK1 0.003 0.003 0.1937
Schistosoma mansoni hypothetical protein 0.0481 0.0958 0.2752
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0036
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0054 0.008 0.023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0054 0.008 0.008
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0006 0.0364
Mycobacterium ulcerans beta-lactamase 0.0031 0.0032 0.0413
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0086 0.5506
Trypanosoma brucei pyruvate kinase 1 0.003 0.003 0.1912
Loa Loa (eye worm) pyruvate kinase-PB 0.0021 0.0011 0.0031
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0131 0.0376
Brugia malayi PHD-finger family protein 0.0057 0.0086 0.0245
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0007 0.0395
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.0091 0.0155 0.0445
Schistosoma mansoni integrin alpha-ps 0.005 0.007 0.0202
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0031 0.0031 0.1969
Loa Loa (eye worm) hypothetical protein 0.1708 0.348 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0032 0.0092
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0006 0.0364
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0161 0.0463
Brugia malayi beta-lactamase family protein 0.0031 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.0052 0.0075 0.0216
Leishmania major alpha glucosidase II subunit, putative 0.0033 0.0035 0.2247
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0079 0.013 0.013
Echinococcus multilocularis pyruvate kinase 0.0024 0.0017 0.0017
Schistosoma mansoni survival motor neuron protein 0.0036 0.0043 0.0124
Echinococcus granulosus integrin alpha ps 0.005 0.007 0.0202
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0052 0.0148
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0048
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0057 0.0086 0.0246
Trypanosoma cruzi pyruvate kinase 2, putative 0.003 0.003 0.1912
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0007 0.0424
Echinococcus granulosus phd:f box containing protein 0.0018 0.0006 0.0018
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0387 0.0765 1
Entamoeba histolytica hypothetical protein 0.0066 0.0103 0.0642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0793 0.1599 1
Mycobacterium tuberculosis Probable esterase LipL 0.0031 0.0032 0.0413
Schistosoma mansoni ran 0.0037 0.0043 0.0125
Toxoplasma gondii ABC1 family protein 0.0031 0.0032 0.2063
Loa Loa (eye worm) hypothetical protein 0.0046 0.0062 0.0178
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0007 0.0424
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0031 0.0031 0.0031
Plasmodium falciparum thioredoxin reductase 0.0041 0.0052 0.335
Mycobacterium ulcerans pyruvate kinase 0.003 0.003 0.0388
Trypanosoma cruzi importin beta-1 subunit, putative 0.004 0.0051 0.327
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0086 0.0246
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.0075 0.0217
Loa Loa (eye worm) MBCTL1 0.0052 0.0075 0.0216
Mycobacterium tuberculosis Probable lipase LipD 0.0031 0.0032 0.0413
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.008 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0161 0.0463
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0006 0.0016
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0037 0.0043 0.2798
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0032 0.0198
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0006 0.0018
Schistosoma mansoni hypothetical protein 0.0024 0.0017 0.0049
Trypanosoma brucei importin beta-1 subunit, putative 0.005 0.007 0.4517
Loa Loa (eye worm) hypothetical protein 0.0034 0.0038 0.0109
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0245
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0032 0.0092
Schistosoma mansoni ran 0.0037 0.0043 0.0125
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0132 0.0132
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0006 0.0018
Echinococcus multilocularis integrin alpha ps 0.005 0.007 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0032 0.2039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0036 0.0043 0.0124
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.001 0.0631
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0091
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0117 0.0335
Onchocerca volvulus 0.0085 0.0143 0.0999
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.0181 0.2358
Loa Loa (eye worm) hypothetical protein 0.025 0.0483 0.1387
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0131 0.0377
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0052 0.015
Mycobacterium tuberculosis Probable hydrolase 0.0031 0.0032 0.0413
Echinococcus multilocularis snurportin 1 0.0531 0.106 0.106
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0075 0.0123 0.0353
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0094 0.0161 0.0161
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0035 0.0218
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0035 0.0218
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0132 0.0378
Schistosoma mansoni integrin alpha-ps 0.0026 0.0021 0.0062
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0031 0.0031 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0793 0.1599 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0352 0.0352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.025 0.0483 0.1387
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.0181 0.205
Mycobacterium tuberculosis Probable lipase LipE 0.0031 0.0032 0.0413
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.0181 0.2358
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0031 0.0031 0.1969
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0037 0.0043 0.2775
Brugia malayi Pre-SET motif family protein 0.0079 0.013 0.0372
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0 0.0001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0091
Echinococcus multilocularis peregrin 0.0059 0.009 0.009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0159 0.2079
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0037 0.0043 0.2775
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.008 0.1034
Loa Loa (eye worm) hypothetical protein 0.0094 0.0161 0.0461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.024 0.0463 0.1329
Echinococcus multilocularis beta LACTamase domain containing family member 0.0031 0.0032 0.0032
Mycobacterium tuberculosis Probable reductase 0.0093 0.0159 0.2079
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0031 0.0031 0.0399
Mycobacterium ulcerans esterase/lipase LipP 0.0031 0.0032 0.0413
Trichomonas vaginalis Importin beta-1 subunit, putative 0.004 0.0051 0.0317
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0131 0.0377
Echinococcus granulosus integrin alpha 3 0.0024 0.0017 0.0049
Schistosoma mansoni cpg binding protein 0.0029 0.0027 0.0079
Trichomonas vaginalis ap endonuclease, putative 0.0031 0.0031 0.0191
Schistosoma mansoni importin beta-1 0.005 0.007 0.0202
Trypanosoma brucei pyruvate kinase 1, putative 0.003 0.003 0.1912
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0016
Brugia malayi jmjC domain containing protein 0.0018 0.0006 0.0016
Schistosoma mansoni cpg binding protein 0.0026 0.0021 0.006
Brugia malayi jmjC domain containing protein 0.0187 0.0352 0.1012
Trypanosoma brucei glucosidase, putative 0.0033 0.0035 0.2247
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0086 0.0247
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.0352 0.1013
Schistosoma mansoni pyruvate kinase 0.003 0.003 0.0087
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0031 0.0031 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0121
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0006 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0463 0.0463
Entamoeba histolytica hypothetical protein 0.0066 0.0103 0.0642
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0387 0.0765 1
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0086 0.0245
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0085
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0062 0.0178
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0006 0.0006
Loa Loa (eye worm) bromodomain containing protein 0.0016 0 0.0000018209
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0021 0.0012 0.0036
Brugia malayi Bromodomain containing protein 0.0059 0.009 0.0257
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0159 0.176
Brugia malayi Bromodomain containing protein 0.0034 0.0038 0.0108
Toxoplasma gondii thioredoxin reductase 0.0041 0.0052 0.335
Brugia malayi hypothetical protein 0.0059 0.0089 0.0255
Echinococcus multilocularis lysosomal alpha glucosidase 0.0147 0.027 0.027
Mycobacterium leprae Probable lipase LipE 0.0031 0.0032 0.0027
Brugia malayi Pyruvate kinase, muscle isozyme 0.003 0.003 0.0085
Toxoplasma gondii HEAT repeat-containing protein 0.005 0.007 0.4534
Plasmodium falciparum glutathione reductase 0.0041 0.0052 0.335
Trichomonas vaginalis sucrase-isomaltase, putative 0.0033 0.0035 0.0218
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0086 0.5506
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0793 0.1599 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0037 0.0043 0.2775
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0062 0.0179
Echinococcus granulosus histone lysine methyltransferase setb 0.0094 0.0161 0.0463
Schistosoma mansoni hypothetical protein 0.0066 0.0103 0.0296
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0086 0.5506
Brugia malayi PHD-finger family protein 0.0024 0.0017 0.0047
Schistosoma mansoni hypothetical protein 0.0018 0.0006 0.0017
Echinococcus granulosus lysosomal alpha glucosidase 0.0147 0.027 0.0777
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0006 0.0393
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0032 0.0034 0.0097
Echinococcus multilocularis geminin 0.0481 0.0958 0.0958
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0035 0.0218
Schistosoma mansoni alpha-glucosidase 0.0126 0.0228 0.0656
Echinococcus granulosus geminin 0.0481 0.0958 0.2752
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0035 0.0218
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0037 0.0043 0.2798
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0062 0.0179
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0006 0.0018
Echinococcus granulosus snurportin 1 0.0531 0.106 0.3044
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.008 0.0229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0066 0.0103 0.0103
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0147 0.027 0.0776
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0006 0.0393
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0062 0.0179
Schistosoma mansoni hypothetical protein 0.0531 0.106 0.3044
Onchocerca volvulus 0.0079 0.013 0.0892
Schistosoma mansoni hypothetical protein 0.0079 0.0131 0.0377
Trichomonas vaginalis maltase-glucoamylase, putative 0.0033 0.0035 0.0218
Plasmodium vivax ataxin-2 like protein, putative 0.0091 0.0155 1
Onchocerca volvulus 0.062 0.1243 1
Trichomonas vaginalis esterase, putative 0.0031 0.0032 0.0198
Onchocerca volvulus Pyruvate kinase homolog 0.003 0.003 0.0075
Echinococcus granulosus GTP binding nuclear protein Ran 0.0037 0.0043 0.0125
Echinococcus granulosus survival motor neuron protein 1 0.0179 0.0336 0.0966
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0031 0.0031 0.0399
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0006 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0463 0.0463
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0032 0.0198
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0031 0.0031 0.0088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0031 0.0032 0.0413
Trypanosoma cruzi pyruvate kinase 2, putative 0.003 0.003 0.1912
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0031 0.0031 0.0194
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.0075 0.0217
Onchocerca volvulus Alhambra homolog 0.0057 0.0086 0.0529
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0032 0.0198
Onchocerca volvulus 0.0036 0.0043 0.0183
Mycobacterium tuberculosis Conserved protein 0.0031 0.0032 0.0413
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0006 0.0364
Brugia malayi jmjC domain containing protein 0.0018 0.0006 0.0016
Brugia malayi Thioredoxin reductase 0.0041 0.0052 0.0148
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.1708 0.348 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0091
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0031 0.0032 0.0413
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0793 0.1599 1
Echinococcus granulosus pyruvate kinase 0.003 0.003 0.0087
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0117 0.0335
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0006 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0031 0.0031 0.1994
Brugia malayi Bromodomain containing protein 0.0068 0.0108 0.0309
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0032 0.0198
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0793 0.1599 1
Echinococcus multilocularis integrin alpha 3 0.0024 0.0017 0.0017
Echinococcus granulosus zinc finger protein 0.0019 0.0007 0.002
Plasmodium falciparum phd finger protein, putative 0.0057 0.0086 0.5506
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0035 0.2247
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0179 0.0336 0.0965
Schistosoma mansoni pyruvate kinase 0.003 0.003 0.0087
Schistosoma mansoni ap endonuclease 0.0031 0.0031 0.0089
Schistosoma mansoni hypothetical protein 0.0079 0.0131 0.0377
Entamoeba histolytica pyruvate kinase, putative 0.0021 0.0011 0.0068
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0006 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.025 0.0483 0.1387
Echinococcus multilocularis lysosomal alpha glucosidase 0.0147 0.027 0.027
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0052 0.335
Echinococcus multilocularis zinc finger protein 0.0019 0.0007 0.0007
Giardia lamblia Fructose-bisphosphate aldolase 0.0793 0.1599 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0387 0.0765 1
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.0019
Toxoplasma gondii exonuclease III APE 0.0031 0.0031 0.1994
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0463 0.133
Brugia malayi beta-lactamase 0.0031 0.0032 0.0091
Schistosoma mansoni bromodomain containing protein 0.0058 0.0087 0.0249
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0159 0.2079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.013 0.0373
Trypanosoma cruzi PAB1-binding protein , putative 0.0091 0.0155 1
Schistosoma mansoni hypothetical protein 0.0079 0.0131 0.0377
Brugia malayi Glycosyl hydrolases family 31 protein 0.0147 0.027 0.0776
Schistosoma mansoni DNA polymerase eta 0.0016 0 0.0001
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0006 0.0006
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0013 0.0036
Giardia lamblia DINP protein human, muc B family 0.0016 0 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0032 0.0027
Brugia malayi CXXC zinc finger family protein 0.0026 0.0021 0.0059
Leishmania major pyruvate kinase 0.003 0.003 0.1912
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0 0.0001
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.003 0.003 0.0388
Plasmodium falciparum pyruvate kinase 0.003 0.003 0.1937
Trypanosoma brucei PAB1-binding protein , putative 0.0091 0.0155 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0062 0.0062
Loa Loa (eye worm) glutathione reductase 0.0041 0.0052 0.0148
Trichomonas vaginalis ap endonuclease, putative 0.0031 0.0031 0.0191
Echinococcus granulosus beta LACTamase domain containing family member 0.0031 0.0032 0.0092
Brugia malayi mbt repeat family protein 0.0046 0.0062 0.0178
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0052 0.3329
Echinococcus granulosus integrin alpha ps 0.0024 0.0017 0.0049
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0032 0.0034 0.0034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0159 0.2079
Brugia malayi AF-10 protein 0.0019 0.0007 0.0018
Toxoplasma gondii LsmAD domain-containing protein 0.0091 0.0155 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0032 0.0198
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0035 0.0218
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0062 0.034
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.1708 0.348 0.348
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0032 0.2039
Schistosoma mansoni hypothetical protein 0.0285 0.0554 0.1591
Loa Loa (eye worm) hypothetical protein 0.0171 0.032 0.0919
Echinococcus granulosus neutral alpha glucosidase AB 0.0033 0.0035 0.0101
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0033 0.0035 0.01
Giardia lamblia Pyruvate kinase 0.003 0.003 0.0188
Echinococcus multilocularis neutral alpha glucosidase AB 0.0033 0.0035 0.0035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.025 0.0483 0.1387
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0035 0.2247
Echinococcus granulosus pyruvate kinase 0.003 0.003 0.0087
Brugia malayi MH2 domain containing protein 0.0222 0.0425 0.1221
Leishmania major trypanothione reductase 0.0041 0.0052 0.3329
Mycobacterium tuberculosis Conserved protein 0.0031 0.0032 0.0413
Onchocerca volvulus Pyruvate kinase homolog 0.003 0.003 0.0075
Onchocerca volvulus 0.0031 0.0032 0.0091
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0006 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0793 0.1599 1
Entamoeba histolytica hypothetical protein 0.0066 0.0103 0.0642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0463 0.133
Leishmania major GTP-binding protein, putative 0.0037 0.0043 0.2775
Loa Loa (eye worm) hypothetical protein 0.0084 0.0141 0.0403
Echinococcus granulosus GPCR family 2 0.0079 0.0131 0.0377
Trichomonas vaginalis set domain proteins, putative 0.062 0.1243 0.7774
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0079 0.013 0.8361
Trichomonas vaginalis pyruvate kinase, putative 0.003 0.003 0.0185
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0035 0.0218
Brugia malayi hypothetical protein 0.0179 0.0336 0.0965
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0352 0.1012
Brugia malayi Integrin alpha pat-2 precursor 0.005 0.007 0.0201
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0031 0.0032 0.0091
Leishmania major hypothetical protein, conserved 0.0031 0.0032 0.2039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.008 0.1034
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.032 0.0919
Mycobacterium tuberculosis Conserved protein 0.0031 0.0032 0.0413
Plasmodium vivax pyruvate kinase, putative 0.003 0.003 0.1937
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.011 0.011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0131 0.0376
Leishmania major hypothetical protein, conserved 0.0018 0.0006 0.0364
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0084 0.0141 0.0403
Loa Loa (eye worm) integrin alpha pat-2 0.011 0.0194 0.0555
Trypanosoma brucei importin beta-1 subunit, putative 0.005 0.007 0.4517
Plasmodium falciparum importin beta, putative 0.005 0.007 0.4534
Schistosoma mansoni zinc finger protein 0.0019 0.0007 0.002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0198 0.0376 0.4912
Trichomonas vaginalis pyruvate kinase, putative 0.003 0.003 0.0185
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.1708 0.348 1
Trichomonas vaginalis ran, putative 0.0037 0.0043 0.0269
Mycobacterium ulcerans lipase LipD 0.0031 0.0032 0.0413
Brugia malayi Glycosyl hydrolases family 31 protein 0.0033 0.0035 0.01
Schistosoma mansoni alpha-glucosidase 0.0126 0.0228 0.0656
Plasmodium vivax hypothetical protein, conserved 0.002 0.001 0.0631
Onchocerca volvulus 0.0031 0.0032 0.0091
Schistosoma mansoni hypothetical protein 0.0041 0.0052 0.015
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0031 0.0032 0.0413
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.0075 0.0216
Loa Loa (eye worm) beta-lactamase 0.0031 0.0032 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.008 0.1034
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0041 0.0052 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0793 0.1599 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0793 0.1599 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0031 0.0031 0.1994
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0031 0.0031 0.1969
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0041 0.0052 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0091 0.0155 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0021 0.0012 0.0036
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0021 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0054 0.008 0.5102
Loa Loa (eye worm) hypothetical protein 0.0098 0.0169 0.0485
Echinococcus granulosus cpg binding protein 0.0029 0.0027 0.0079
Brugia malayi hypothetical protein 0.0091 0.0155 0.0445
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0159 0.2079
Treponema pallidum fructose-bisphosphate aldolase 0.0793 0.1599 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0793 0.1599 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0078 0.5031
Trypanosoma cruzi PAB1-binding protein , putative 0.0091 0.0155 1
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0006 0.0006
Brugia malayi jmjC domain containing protein 0.0018 0.0006 0.0016
Schistosoma mansoni integrin alpha 0.005 0.007 0.0202
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0031
Brugia malayi beta-lactamase family protein 0.0031 0.0032 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0463 0.133
Plasmodium vivax JmjC domain containing protein 0.0018 0.0006 0.0393
Brugia malayi Pre-SET motif family protein 0.0545 0.1089 0.3127
Loa Loa (eye worm) hypothetical protein 0.0079 0.0131 0.0376
Loa Loa (eye worm) pyruvate kinase 0.003 0.003 0.0085
Echinococcus multilocularis pyruvate kinase 0.003 0.003 0.003
Loa Loa (eye worm) pyruvate kinase 0.003 0.003 0.0085
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0066 0.0103 0.0296
Brugia malayi mbt repeat family protein 0.0046 0.0062 0.0178
Trichomonas vaginalis Importin beta-1 subunit, putative 0.004 0.0051 0.0317
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.024 0.0463 0.1329
Mycobacterium ulcerans hypothetical protein 0.0031 0.0032 0.0413
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0031 0.0031 0.1969
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.0075 0.0217
Onchocerca volvulus 0.0031 0.0032 0.0091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0131 0.0376
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.0075 0.0075
Plasmodium vivax importin-beta 2, putative 0.005 0.007 0.4534
Brugia malayi PHD-finger family protein 0.0022 0.0013 0.0036
Echinococcus granulosus dna polymerase kappa 0.0016 0 0.0001
Entamoeba histolytica hypothetical protein 0.004 0.0051 0.0317
Schistosoma mansoni hypothetical protein 0.0079 0.0131 0.0377
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.0075 0.0075
Chlamydia trachomatis pyruvate kinase 0.003 0.003 0.5
Echinococcus granulosus dna polymerase eta 0.0016 0 0.0001
Toxoplasma gondii aldehyde dehydrogenase 0.0054 0.008 0.5117
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0054 0.008 0.1034
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0037 0.0043 0.0043
Schistosoma mansoni jumonji domain containing protein 0.0148 0.0274 0.0786
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0054 0.008 0.0229
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0545 0.1089 0.3127
Onchocerca volvulus Pyruvate kinase homolog 0.003 0.003 0.0075
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0062 0.0062
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0006 0.0018
Brugia malayi Importin beta-1 subunit 0.005 0.007 0.0201
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0037 0.0043 0.2798
Onchocerca volvulus 0.0046 0.0062 0.034
Leishmania major importin beta-1 subunit, putative 0.004 0.0051 0.327
Brugia malayi exodeoxyribonuclease III family protein 0.0031 0.0031 0.0088
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0037 0.0043 0.0272
Giardia lamblia PHD finger protein 15 0.0057 0.0086 0.0535
Leishmania major hypothetical protein, conserved 0.0091 0.0155 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.021 0.0604
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0037 0.0043 0.0124
Brugia malayi RNA, U transporter 1 0.0141 0.0259 0.0743
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0463 0.133
Entamoeba histolytica hypothetical protein 0.0066 0.0103 0.0642
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0035 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0079 0.013 0.0373
Echinococcus granulosus importin subunit beta 1 0.005 0.007 0.0202
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0033 0.0035 0.2271
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0032 0.2039
Loa Loa (eye worm) hypothetical protein 0.005 0.007 0.0201
Loa Loa (eye worm) hypothetical protein 0.0039 0.0049 0.014
Trypanosoma brucei trypanothione reductase 0.0041 0.0052 0.3329
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0031 0.0032 0.0413
Brugia malayi jmjC domain containing protein 0.0018 0.0006 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0117 0.0334
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0091
Schistosoma mansoni hypothetical protein 0.0481 0.0958 0.2752
Brugia malayi hypothetical protein 0.0066 0.0103 0.0295
Schistosoma mansoni ap endonuclease 0.0031 0.0031 0.0089
Schistosoma mansoni alpha glucosidase 0.0033 0.0035 0.0101
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0006 0.0016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0035 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0463 0.133
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0793 0.1599 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0159 0.2079
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0031 0.0032 0.0091
Plasmodium vivax glutathione reductase, putative 0.0041 0.0052 0.335
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0062 0.0179
Brugia malayi Pyruvate kinase, M2 isozyme 0.003 0.003 0.0085
Loa Loa (eye worm) MH2 domain-containing protein 0.0222 0.0425 0.1221
Echinococcus multilocularis integrin alpha ps 0.0024 0.0017 0.0017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.0181 0.2358
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0013 0.0013
Brugia malayi jmjC domain containing protein 0.0072 0.0117 0.0334
Echinococcus multilocularis GPCR, family 2 0.0079 0.0131 0.0131
Echinococcus multilocularis importin subunit beta 1 0.005 0.007 0.007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0021 0.0059
Echinococcus multilocularis integrin alpha ps 0.005 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.006
Loa Loa (eye worm) transcription factor SMAD2 0.0222 0.0425 0.1221
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.1708 0.348 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0086 0.0246
Brugia malayi glutathione reductase 0.0041 0.0052 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0032 0.2063
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0062 0.0179
Echinococcus granulosus peregrin 0.0059 0.009 0.0258
Trichomonas vaginalis importin beta-1, putative 0.004 0.0051 0.0317
Loa Loa (eye worm) pyruvate kinase 0.003 0.003 0.0085
Entamoeba histolytica Ran family GTPase 0.0037 0.0043 0.0269
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0052 0.0675
Schistosoma mansoni transcription factor LCR-F1 0.0066 0.0103 0.0296
Leishmania major pyruvate kinase 0.003 0.003 0.1912
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0131 0.0131
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0036 0.0043 0.0123
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0117 0.0335
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0531 0.106 0.3043
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0037 0.0043 0.0124
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0035 0.0218
Plasmodium vivax SET domain protein, putative 0.0079 0.013 0.8361

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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