Detailed information for compound 1822063

Basic information

Technical information
  • TDR Targets ID: 1822063
  • Name: (2R,3S,4aS,7R,8R,8aS)-2,3,4'-trihydroxy-4,4,7 ,8a-tetramethylspiro[2,3,4a,5,6,7-hexahydro-1 H-naphthalene-8,2'-7,8-dihydro-3H-furo[5,4-e] isoindole]-6'-one
  • MW: 401.496 | Formula: C23H31NO5
  • H donors: 4 H acceptors: 4 LogP: 2.77 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1C[C@@]2(C)[C@H](C([C@@H]1O)(C)C)CC[C@H]([C@@]12Cc2c(O1)c1CNC(=O)c1cc2O)C
  • InChi: 1S/C23H31NO5/c1-11-5-6-17-21(2,3)19(27)16(26)9-22(17,4)23(11)8-13-15(25)7-12-14(18(13)29-23)10-24-20(12)28/h7,11,16-17,19,25-27H,5-6,8-10H2,1-4H3,(H,24,28)/t11-,16-,17+,19-,22+,23-/m1/s1
  • InChiKey: RUBLIKRGQGISNL-DXORJMCXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,2'S,3'R,4'aS,6'R,8'aS)-2',3',4-trihydroxy-1',1',4'a,6'-tetramethyl-spiro[7,8-dihydro-3H-furo[5,4-e]isoindole-2,5'-decalin]-6-one
  • (2R,2'S,3'R,4'aS,6'R,8'aS)-2',3',4-trihydroxy-1',1',4'a,6'-tetramethyl-6-spiro[7,8-dihydro-3H-furo[5,4-e]isoindole-2,5'-decalin]one
  • (2R,3S,4aS,7R,8R,8aS)-2,3,4'-trihydroxy-4,4,7,8a-tetramethyl-spiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-7,8-dihydro-3H-furo[5,4-e]isoindole]-6'-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0602 0.33 0.9715
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0305 0.1629 0.3231
Echinococcus granulosus tyrosine protein kinase 0.0602 0.33 0.6566
Schistosoma mansoni hypothetical protein 0.0189 0.0976 0.1944
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Brugia malayi hypothetical protein 0.0602 0.33 0.9715
Echinococcus granulosus anosmin 1 0.0305 0.1629 0.3231
Echinococcus multilocularis Netrin receptor DCC 0.0305 0.1629 0.1621
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0602 0.33 0.997
Echinococcus multilocularis cell adhesion molecule 0.0305 0.1629 0.1621
Echinococcus granulosus GPCR family 2 0.0061 0.0253 0.0484
Schistosoma mansoni protein kinase 0.0602 0.33 0.6573
Onchocerca volvulus 0.0602 0.33 0.971
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Echinococcus granulosus protein tyrosine kinase 0.0602 0.33 0.6566
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0619 0.3395 0.6756
Echinococcus multilocularis c src tyrosine kinase 0.0602 0.33 0.3293
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0619 0.3395 1
Echinococcus multilocularis Netrin receptor DCC 0.0305 0.1629 0.1621
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni protein kinase 0.0602 0.33 0.6573
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.012 0.5
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Trichomonas vaginalis AGC family protein kinase 0.0602 0.33 1
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0602 0.33 0.6573
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0602 0.33 0.6566
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Trypanosoma brucei protein kinase, putative 0.0604 0.331 1
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Echinococcus granulosus Fibronectin type III domain containing protein 0.0305 0.1629 0.3231
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0604 0.331 1
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0602 0.33 0.9715
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Loa Loa (eye worm) TK/FAK protein kinase 0.0602 0.33 0.9719
Echinococcus multilocularis neuroglian 0.0305 0.1629 0.1621
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0604 0.331 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0202 0.1046 0.2827
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Schistosoma mansoni serine/threonine protein kinase 0.0602 0.33 0.6573
Echinococcus granulosus tyrosine protein kinase pr2 0.0602 0.33 0.6566
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Onchocerca volvulus 0.0305 0.1629 0.4609
Echinococcus granulosus G1Y162 protein 0.0305 0.1629 0.3231
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.012 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0682 0.1359
Brugia malayi Fibronectin type III domain containing protein 0.0305 0.1629 0.471
Entamoeba histolytica protein kinase domain containing protein 0.0604 0.331 1
Schistosoma mansoni neuroglian 0.0305 0.1629 0.3245
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0602 0.33 0.6566
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0123 0.0225
Echinococcus granulosus raf serine:threonine protein kinase 0.0602 0.33 0.6566
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.001 0.0021
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Brugia malayi N-terminal motif family protein 0.0202 0.1046 0.2961
Loa Loa (eye worm) TK/ABL protein kinase 0.0602 0.33 0.9719
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0305 0.1629 0.1621
Loa Loa (eye worm) RGC/RGC protein kinase 0.0602 0.33 0.9719
Echinococcus multilocularis tyrosine protein kinase pr2 0.0602 0.33 0.3293
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0602 0.33 0.6566
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Plasmodium vivax tyrosine kinase-like protein, putative 0.0602 0.33 1
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.33 1
Brugia malayi SH2 domain containing protein 0.0602 0.33 0.9715
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Toxoplasma gondii protein kinase 0.0602 0.33 0.9968
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.012 0.5
Mycobacterium ulcerans lipase LipD 0.0037 0.012 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0265 0.0508
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Onchocerca volvulus 0.0305 0.1629 0.4609
Echinococcus multilocularis tyrosine protein kinase HCK 0.0602 0.33 0.3293
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Echinococcus granulosus Netrin receptor DCC 0.0305 0.1629 0.3231
Echinococcus granulosus activated cdc42 kinase 1 0.0602 0.33 0.6566
Echinococcus granulosus anosmin 1 0.0305 0.1629 0.3231
Schistosoma mansoni hypothetical protein 0.0061 0.0253 0.0504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Brugia malayi Bromodomain containing protein 0.0079 0.0356 0.0896
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Brugia malayi hypothetical protein 0.008 0.036 0.0907
Loa Loa (eye worm) SRC-1 0.0602 0.33 0.9719
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0602 0.33 0.3293
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0602 0.33 0.3293
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.012 0.0323
Entamoeba histolytica cysteine surface protein, putative 0.0602 0.33 0.9966
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Entamoeba histolytica receptor protein kinase, putative 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Schistosoma mansoni factor for adipocyte differentiation 0.0305 0.1629 0.3245
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Schistosoma mansoni protein kinase 0.0604 0.331 0.6593
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.012 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.33 1
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0604 0.331 1
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0061 0.0253 0.0484
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0305 0.1629 0.1621
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0323
Schistosoma mansoni nephrin 0.0305 0.1629 0.3245
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Echinococcus multilocularis geminin 0.0189 0.0976 0.0967
Schistosoma mansoni hypothetical protein 0.0061 0.0253 0.0504
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Brugia malayi myotactin form B 0.0305 0.1629 0.471
Echinococcus multilocularis insulin receptor 0.0602 0.33 0.3293
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Echinococcus multilocularis anosmin 1 0.0305 0.1629 0.1621
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Echinococcus multilocularis roundabout 2 0.0305 0.1629 0.1621
Schistosoma mansoni hypothetical protein 0.0132 0.0653 0.13
Echinococcus multilocularis protein kinase 0.0602 0.33 0.3293
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0305 0.1629 0.3245
Onchocerca volvulus 0.0602 0.33 0.971
Echinococcus multilocularis tyrosine protein kinase 0.0602 0.33 0.3293
Schistosoma mansoni protein kinase 0.0602 0.33 0.6573
Brugia malayi Latrophilin receptor protein 2 0.0061 0.0253 0.0586
Brugia malayi myotactin form A 0.0305 0.1629 0.471
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0682 0.1341
Brugia malayi protein unc-22 0.0307 0.1639 0.474
Echinococcus granulosus zinc finger protein 0.0021 0.0026 0.003
Echinococcus granulosus tyrosine protein kinase Src42A 0.0602 0.33 0.6566
Plasmodium falciparum protein kinase, putative 0.0604 0.331 1
Echinococcus granulosus fibronectin type III domain-containing protein 0.0305 0.1629 0.3231
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0602 0.33 0.9966
Echinococcus granulosus anosmin 1 0.0305 0.1629 0.3231
Schistosoma mansoni protein kinase 0.0602 0.33 0.6573
Schistosoma mansoni hypothetical protein 0.008 0.036 0.0717
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0602 0.33 0.971
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Plasmodium vivax tyrosine kinase-like protein, putative 0.0602 0.33 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0602 0.33 0.3293
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0619 0.3395 1
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Loa Loa (eye worm) lethal protein 805 0.0305 0.1629 0.4783
Entamoeba histolytica serine/threonine kinase, putative 0.0602 0.33 0.9966
Echinococcus granulosus kinase suppressor of Ras 1 0.0602 0.33 0.6566
Entamoeba histolytica receptor protein kinase, putative 0.0602 0.33 0.9966
Echinococcus granulosus epidermal growth factor receptor 0.0602 0.33 0.6566
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni hemicentin 0.0305 0.1629 0.3245
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Schistosoma mansoni protein kinase 0.0602 0.33 0.6573
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0602 0.33 0.6573
Echinococcus granulosus tyrosine protein kinase HCK 0.0602 0.33 0.6566
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Onchocerca volvulus 0.0305 0.1629 0.4609
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0602 0.33 0.6566
Brugia malayi SRC-1 0.0602 0.33 0.9715
Trichomonas vaginalis TK family protein kinase 0.0602 0.33 1
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Echinococcus granulosus activin receptor type 0.0604 0.331 0.6586
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0602 0.33 0.6566
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0602 0.33 0.3293
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0043 0.0033
Loa Loa (eye worm) TK/CSK protein kinase 0.0602 0.33 0.9719
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Mycobacterium ulcerans hypothetical protein 0.0037 0.012 0.5
Onchocerca volvulus 0.0602 0.33 0.971
Loa Loa (eye worm) hypothetical protein 0.0132 0.0653 0.1897
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Entamoeba histolytica tyrosin kinase, putative 0.0602 0.33 0.9966
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Schistosoma mansoni cell adhesion molecule 0.0305 0.1629 0.3245
Trypanosoma brucei Flagellum attachment zone protein 20 0.0602 0.33 0.997
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0602 0.33 0.3293
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus granulosus tyrosine protein kinase shark 0.0602 0.33 0.6566
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0323
Schistosoma mansoni ephrin receptor 0.0907 0.5021 1
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0305 0.1629 0.471
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Loa Loa (eye worm) latrophilin receptor protein 2 0.0061 0.0253 0.0717
Echinococcus multilocularis transfer RNA-Phe 0.0305 0.1629 0.1621
Brugia malayi Lethal protein 805 0.0305 0.1629 0.471
Giardia lamblia Kinase, NEK 0.0602 0.33 0.5
Schistosoma mansoni serine/threonine RGC 0.0602 0.33 0.6573
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0193 0.0997 0.2915
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0307 0.1639 0.4813
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0602 0.33 0.3293
Brugia malayi beta-lactamase family protein 0.0037 0.012 0.0187
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0602 0.33 0.3293
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.001 0.0021
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0619 0.3395 1
Echinococcus granulosus integrin linked protein kinase 0.0602 0.33 0.6566
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0043 0.0086
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0602 0.33 0.9719
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0305 0.1629 0.1621
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0602 0.33 0.3293
Echinococcus granulosus neuroglian 0.0305 0.1629 0.3231
Schistosoma mansoni tripartite motif protein trim9 0.0305 0.1629 0.3245
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Echinococcus multilocularis receptor type guanylyl cyclase 0.0602 0.33 0.3293
Echinococcus granulosus retinal guanylyl cyclase 2 0.0602 0.33 0.6566
Onchocerca volvulus 0.0602 0.33 0.971
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0682 0.1359
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0602 0.33 0.9719
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0032 0.0063
Entamoeba histolytica serine/threonine kinase, putative 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Schistosoma mansoni hypothetical protein 0.0305 0.1629 0.3245
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0602 0.33 0.3293
Mycobacterium ulcerans beta-lactamase 0.0037 0.012 0.5
Leishmania major hypothetical protein, conserved 0.0037 0.012 0.0362
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.33 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0602 0.33 0.9715
Schistosoma mansoni serine/threonine protein kinase 0.0602 0.33 0.6573
Onchocerca volvulus 0.0602 0.33 0.971
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Schistosoma mansoni protein kinase 0.0602 0.33 0.6573
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Brugia malayi beta-lactamase 0.0037 0.012 0.0187
Echinococcus granulosus retinal guanylyl cyclase 2 0.0602 0.33 0.6566
Trichomonas vaginalis STE family protein kinase 0.0602 0.33 1
Trichomonas vaginalis CAMK family protein kinase 0.0602 0.33 1
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Onchocerca volvulus 0.0602 0.33 0.971
Schistosoma mansoni cell adhesion molecule 0.0305 0.1629 0.3245
Onchocerca volvulus 0.0305 0.1629 0.4609
Entamoeba histolytica serine/threonine kinase, putative 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Entamoeba histolytica serine/threonine kinase, putative 0.0602 0.33 0.9966
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0604 0.331 0.3303
Brugia malayi Protein kinase domain containing protein 0.0619 0.3395 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0602 0.33 1
Schistosoma mansoni titin 0.0305 0.1629 0.3245
Brugia malayi hypothetical protein 0.0602 0.33 0.9715
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0602 0.33 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.012 0.0362
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0305 0.1629 0.3231
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0602 0.33 1
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Onchocerca volvulus 0.0602 0.33 0.971
Echinococcus multilocularis activin receptor type 0.0604 0.331 0.3303
Echinococcus multilocularis tyrosine protein kinase csk 0.0602 0.33 0.3293
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0602 0.33 0.3293
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Brugia malayi C-terminal src kinase protein 1 0.0602 0.33 0.9715
Echinococcus granulosus ephrin type A receptor 4 A 0.0602 0.33 0.6566
Leishmania major hypothetical protein, conserved 0.0305 0.1629 0.4922
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0907 0.5021 0.5016
Giardia lamblia Protein 21.1 0.0602 0.33 0.5
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Echinococcus granulosus usherin 0.0305 0.1629 0.3231
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Entamoeba histolytica serine/threonine kinase, putative 0.0602 0.33 0.9966
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0305 0.1629 0.471
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0682 0.0673
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0305 0.1629 0.4922
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0604 0.331 1
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.001 0.0021
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0602 0.33 0.6566
Echinococcus multilocularis tyrosine kinase 0.0602 0.33 0.3293
Echinococcus granulosus geminin 0.0189 0.0976 0.1927
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0061 0.0253 0.0586
Schistosoma mansoni protein kinase 0.0604 0.331 0.6593
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0602 0.33 0.6566
Brugia malayi SH2 domain containing protein 0.0602 0.33 0.9715
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Echinococcus multilocularis integrin linked protein kinase 0.0602 0.33 0.3293
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0602 0.33 0.6573
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Loa Loa (eye worm) TK/Met protein kinase 0.0602 0.33 0.9719
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Loa Loa (eye worm) hypothetical protein 0.0043 0.0152 0.0418
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0193 0.0997 0.2815
Schistosoma mansoni serine/threonine protein kinase 0.0602 0.33 0.6573
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Brugia malayi Fibronectin type III domain containing protein 0.0305 0.1629 0.471
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0682 0.0673
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0602 0.33 0.6566
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0682 0.1985
Echinococcus multilocularis titin 0.0307 0.1639 0.1631
Echinococcus multilocularis roundabout 2 0.0305 0.1629 0.1621
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0305 0.1629 0.4783
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0602 0.33 0.3293
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni hypothetical protein 0.0602 0.33 0.6573
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0602 0.33 0.3293
Echinococcus granulosus insulin receptor 0.0602 0.33 0.6566
Echinococcus granulosus EG95 0.0305 0.1629 0.3231
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Toxoplasma gondii protein kinase domain-containing protein 0.0602 0.33 0.9968
Brugia malayi Fibronectin type III domain containing protein 0.0305 0.1629 0.471
Echinococcus granulosus tyrosine protein kinase Srms 0.0602 0.33 0.6566
Onchocerca volvulus 0.0305 0.1629 0.4609
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0043 0.0065
Echinococcus multilocularis usherin 0.0305 0.1629 0.1621
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.33 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.33 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.012 0.0362
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Echinococcus granulosus c src tyrosine kinase 0.0602 0.33 0.6566
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0602 0.33 0.6566
Brugia malayi Fibronectin type III domain containing protein 0.0305 0.1629 0.471
Echinococcus multilocularis natriuretic peptide receptor 1 0.0602 0.33 0.3293
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Echinococcus granulosus roundabout 2 0.0305 0.1629 0.3231
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Brugia malayi Immunoglobulin I-set domain containing protein 0.0602 0.33 0.9715
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0682 0.1341
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0323
Schistosoma mansoni nephrin 0.0305 0.1629 0.3245
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Entamoeba histolytica ankyrin repeat protein 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0619 0.3395 0.3388
Loa Loa (eye worm) hypothetical protein 0.0202 0.1046 0.3059
Onchocerca volvulus 0.0305 0.1629 0.4609
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0602 0.33 1
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Trypanosoma cruzi protein kinase, putative 0.0602 0.33 0.997
Echinococcus granulosus tyrosine protein kinase csk 0.0602 0.33 0.6566
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis protein tyrosine kinase 0.0602 0.33 0.3293
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.012 0.0187
Loa Loa (eye worm) TK/EPH protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0602 0.33 0.9719
Echinococcus multilocularis epidermal growth factor receptor 0.0602 0.33 0.3293
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Schistosoma mansoni bromodomain containing protein 0.0067 0.0286 0.057
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Trichomonas vaginalis protein kinase atn1, putative 0.0602 0.33 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0307 0.1639 0.4813
Onchocerca volvulus 0.0305 0.1629 0.4609
Schistosoma mansoni cell adhesion molecule 0.0305 0.1629 0.3245
Schistosoma mansoni zinc finger protein 0.0021 0.0026 0.0051
Loa Loa (eye worm) TK/RYK protein kinase 0.0602 0.33 0.9719
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0026 0.0015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Echinococcus granulosus tyrosine protein kinase Lyn 0.0604 0.331 0.6586
Schistosoma mansoni factor for adipocyte differentiation 0.0305 0.1629 0.3245
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0602 0.33 0.3293
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0305 0.1629 0.1621
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Loa Loa (eye worm) protein kinase domain-containing protein 0.0602 0.33 0.9719
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0602 0.33 0.3293
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0305 0.1629 0.1621
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0305 0.1629 0.3231
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0041 0.0138 0.0376
Schistosoma mansoni hypothetical protein 0.0061 0.0253 0.0504
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0604 0.331 0.6586
Onchocerca volvulus 0.0602 0.33 0.971
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni myosin-binding protein-related 0.0305 0.1629 0.3245
Echinococcus multilocularis titin 0.0305 0.1629 0.1621
Brugia malayi Furin-like cysteine rich region family protein 0.0602 0.33 0.9715
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Brugia malayi ephrin receptor 1 precursor 0.0602 0.33 0.9715
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0305 0.1629 0.3245
Echinococcus granulosus Fibronectin type III 0.0305 0.1629 0.3231
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.012 0.0239
Echinococcus granulosus retinal guanylyl cyclase 2 0.0602 0.33 0.6566
Echinococcus multilocularis tyrosine protein kinase csk 0.0602 0.33 0.3293
Schistosoma mansoni cell adhesion molecule 0.0305 0.1629 0.3245
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0602 0.33 0.3293
Loa Loa (eye worm) TK/DDR protein kinase 0.0602 0.33 0.9719
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0305 0.1629 0.1621
Brugia malayi Fibronectin type III domain containing protein 0.0305 0.1629 0.471
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0602 0.33 0.3293
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0305 0.1629 0.471
Giardia lamblia Kinase 0.0602 0.33 0.5
Echinococcus multilocularis kinase suppressor of Ras 1 0.0602 0.33 0.3293
Entamoeba histolytica hypothetical protein, conserved 0.0602 0.33 0.9966
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.012 0.0362
Schistosoma mansoni tyrosine protein kinase 0.0602 0.33 0.6573
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Brugia malayi integrin-linked kinase 0.0602 0.33 0.9715
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Brugia malayi Receptor family ligand binding region containing protein 0.0602 0.33 0.9715
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0305 0.1629 0.4783
Onchocerca volvulus Tyrosine kinase homolog 0.0602 0.33 0.971
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0602 0.33 0.6566
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0602 0.33 0.6573
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Schistosoma mansoni factor for adipocyte differentiation 0.0305 0.1629 0.3245
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0602 0.33 0.9715
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Echinococcus multilocularis protein KINase family member (kin 25) 0.0602 0.33 0.3293
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0602 0.33 0.6573
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0602 0.33 0.9719
Echinococcus granulosus tyrosine kinase 0.0602 0.33 0.6566
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0305 0.1629 0.3245
Brugia malayi Bromodomain containing protein 0.0041 0.0137 0.0239
Schistosoma mansoni cell adhesion molecule 0.0305 0.1629 0.3245
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) UNCoordinated family member 0.0305 0.1629 0.4783
Onchocerca volvulus 0.0602 0.33 0.971
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Echinococcus granulosus roundabout 2 0.0305 0.1629 0.3231
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.012 0.0239
Brugia malayi Raf kinase 0.0602 0.33 0.9715
Echinococcus multilocularis tyrosine protein kinase Blk 0.0602 0.33 0.3293
Echinococcus granulosus tyrosine protein kinase Fyn 0.0602 0.33 0.6566
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Echinococcus granulosus contactin 0.0305 0.1629 0.3231
Leishmania major protein kinase, putative 0.0602 0.33 0.997
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0602 0.33 0.9719
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0602 0.33 0.9715
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0602 0.33 0.3293
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Echinococcus multilocularis transfer RNA-Thr 0.0602 0.33 0.3293
Echinococcus multilocularis ephrin type A receptor 4 A 0.0602 0.33 0.3293
Trypanosoma cruzi protein kinase, putative 0.0602 0.33 0.997
Onchocerca volvulus 0.0602 0.33 0.971
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0602 0.33 0.9966
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0061 0.0253 0.0484
Loa Loa (eye worm) TK/ROR protein kinase 0.0602 0.33 0.9719
Echinococcus granulosus epidermal growth factor receptor 0.0602 0.33 0.6566
Loa Loa (eye worm) hypothetical protein 0.0061 0.0253 0.0717
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0305 0.1629 0.4783
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0305 0.1629 0.4783
Toxoplasma gondii STE kinase 0.0602 0.33 0.9968
Onchocerca volvulus 0.0602 0.33 0.971
Brugia malayi hypothetical protein 0.0602 0.33 0.9715
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0602 0.33 0.9719
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0305 0.1629 0.3231
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Schistosoma mansoni hypothetical protein 0.0061 0.0253 0.0504
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Schistosoma mansoni hypothetical protein 0.0189 0.0976 0.1944
Echinococcus granulosus natriuretic peptide receptor 1 0.0602 0.33 0.6566
Echinococcus granulosus roundabout 2 0.0305 0.1629 0.3231
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0602 0.33 0.9715
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Entamoeba histolytica tyrosin kinase, putative 0.0602 0.33 0.9966
Echinococcus multilocularis FL cytokine receptor 0.0602 0.33 0.3293
Brugia malayi Lethal protein 805 0.0305 0.1629 0.471
Loa Loa (eye worm) TK/INSR protein kinase 0.0602 0.33 0.9719
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0602 0.33 0.3293
Trypanosoma brucei Pseudokinase, putative 0.0602 0.33 0.997
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.036 0.035
Loa Loa (eye worm) TK/ACK protein kinase 0.0602 0.33 0.9719
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis epidermal growth factor receptor 0.0602 0.33 0.3293
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Schistosoma mansoni hypothetical protein 0.0305 0.1629 0.3245
Schistosoma mansoni hypothetical protein 0.0022 0.0032 0.0063
Onchocerca volvulus 0.0305 0.1629 0.4609
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Brugia malayi Guanylyl cyclase protein 23 0.0602 0.33 0.9715
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.33 1
Schistosoma mansoni serine/threonine protein kinase 0.0307 0.1639 0.3265
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0305 0.1629 0.1621
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Echinococcus multilocularis anosmin 1 0.0305 0.1629 0.1621
Loa Loa (eye worm) projectin 0.0305 0.1629 0.4783
Schistosoma mansoni protein kinase 0.0602 0.33 0.6573
Loa Loa (eye worm) TK/ALK protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0602 0.33 0.6573
Brugia malayi latrophilin 2 splice variant baaae 0.0132 0.0653 0.1784
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0305 0.1629 0.1621
Brugia malayi beta-lactamase family protein 0.0037 0.012 0.0187
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis Fibronectin, type III 0.0305 0.1629 0.1621
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.1257 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0602 0.33 0.3293
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Echinococcus granulosus protein kinase 0.0602 0.33 0.6566
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Echinococcus multilocularis GPCR, family 2 0.0061 0.0253 0.0243
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0602 0.33 0.3293
Echinococcus granulosus nephrin 0.0305 0.1629 0.3231
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0602 0.33 0.3293
Echinococcus granulosus fibroblast growth factor receptor 4 0.0602 0.33 0.6566
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Echinococcus granulosus cell adhesion molecule 0.0305 0.1629 0.3231
Loa Loa (eye worm) hypothetical protein 0.0193 0.0997 0.2915
Onchocerca volvulus 0.0602 0.33 0.971
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0602 0.33 0.9966
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Entamoeba histolytica ankyrin repeat protein 0.0602 0.33 0.9966
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Echinococcus multilocularis tyrosine protein kinase Srms 0.0602 0.33 0.3293
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0602 0.33 0.3293
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Entamoeba histolytica protein kinase domain containing protein 0.0602 0.33 0.9966
Brugia malayi hypothetical protein 0.0305 0.1629 0.471
Brugia malayi Protein-tyrosine phosphatase 0.0305 0.1629 0.471
Loa Loa (eye worm) serine/threonine protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0305 0.1629 0.4922
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.036 0.0698
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0305 0.1629 0.3245
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus granulosus titin 0.0307 0.1639 0.3251
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0682 0.1359
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0602 0.33 0.6566
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0602 0.33 0.6566
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0602 0.33 0.6566
Onchocerca volvulus 0.0305 0.1629 0.4609
Loa Loa (eye worm) TK/EGFR protein kinase 0.0602 0.33 0.9719
Entamoeba histolytica tyrosin kinase, putative 0.0602 0.33 0.9966
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0323
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Onchocerca volvulus 0.0305 0.1629 0.4609
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0602 0.33 0.3293
Echinococcus multilocularis anosmin 1 0.0305 0.1629 0.1621
Onchocerca volvulus 0.0602 0.33 0.971
Entamoeba histolytica tyrosin kinase, putative 0.0602 0.33 0.9966
Echinococcus granulosus tyrosine protein kinase Fyn 0.0602 0.33 0.6566
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0602 0.33 0.9715
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0602 0.33 0.3293
Echinococcus granulosus tyrosine protein kinase csk 0.0602 0.33 0.6566
Schistosoma mansoni serine/threonine protein kinase 0.0602 0.33 0.6573
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Schistosoma mansoni protein kinase 0.0604 0.331 0.6593
Loa Loa (eye worm) hypothetical protein 0.0075 0.0331 0.0946
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0602 0.33 0.3293
Onchocerca volvulus 0.0602 0.33 0.971
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Trypanosoma cruzi hypothetical protein, conserved 0.0305 0.1629 0.4922
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0305 0.1629 0.4783
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Onchocerca volvulus 0.0307 0.1639 0.464
Schistosoma mansoni protein kinase 0.0602 0.33 0.6573
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0602 0.33 0.6573
Echinococcus multilocularis tyrosine protein kinase shark 0.0602 0.33 0.3293
Echinococcus granulosus tyrosine kinase 0.0602 0.33 0.6566
Echinococcus granulosus tyrosine protein kinase ABL1 0.0602 0.33 0.6566
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Onchocerca volvulus 0.0305 0.1629 0.4609
Loa Loa (eye worm) hypothetical protein 0.0045 0.0163 0.0451
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0061 0.0253 0.0243
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0682 0.1873
Loa Loa (eye worm) RGC/RGC protein kinase 0.0602 0.33 0.9719
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0305 0.1629 0.4783
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0305 0.1629 0.4783
Echinococcus multilocularis activated cdc42 kinase 1 0.0602 0.33 0.3293
Entamoeba histolytica serine/threonine kinase, putative 0.0602 0.33 0.9966
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0602 0.33 0.9715
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0602 0.33 0.9968
Plasmodium vivax protein kinase, putative 0.0602 0.33 1
Brugia malayi Tyrosine-protein kinase PR2 0.0602 0.33 0.9715
Echinococcus granulosus tyrosine protein kinase Src64B 0.0602 0.33 0.6566
Leishmania major protein kinase, putative 0.0604 0.331 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0305 0.1629 0.3231
Loa Loa (eye worm) beta-lactamase 0.0037 0.012 0.0323
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0323
Schistosoma mansoni titin 0.0307 0.1639 0.3265
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0602 0.33 0.3293
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0602 0.33 0.6566
Brugia malayi bone morphogenetic protein type 1 receptor 0.0602 0.33 0.9715
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0305 0.1629 0.3245
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Brugia malayi Fibronectin type III domain containing protein 0.0305 0.1629 0.471
Loa Loa (eye worm) TK protein kinase 0.0602 0.33 0.9719
Loa Loa (eye worm) CAMK protein kinase 0.0307 0.1639 0.4813
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0305 0.1629 0.4783
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0619 0.3395 1
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Brugia malayi protein-tyrosine kinase 0.0602 0.33 0.9715
Mycobacterium leprae Probable lipase LipE 0.0037 0.012 0.5
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Onchocerca volvulus 0.0602 0.33 0.971
Echinococcus granulosus titin 0.0307 0.1639 0.3251
Brugia malayi Immunoglobulin I-set domain containing protein 0.0307 0.1639 0.474
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Onchocerca volvulus 0.0305 0.1629 0.4609
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0305 0.1629 0.3231
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus granulosus tyrosine kinase 0.0602 0.33 0.6566
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0602 0.33 0.3293
Echinococcus multilocularis tyrosine kinase 0.0602 0.33 0.3293
Schistosoma mansoni protein tyrosine phosphatase 0.0305 0.1629 0.3245
Schistosoma mansoni titin 0.0305 0.1629 0.3245
Onchocerca volvulus 0.0305 0.1629 0.4609
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Schistosoma mansoni hypothetical protein 0.0305 0.1629 0.3245
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0602 0.33 0.6566
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0305 0.1629 0.3231
Brugia malayi SPRY domain containing protein 0.0305 0.1629 0.471
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0305 0.1629 0.4783
Echinococcus granulosus Netrin receptor DCC 0.0305 0.1629 0.3231
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0305 0.1629 0.1621
Entamoeba histolytica hypothetical protein 0.0602 0.33 0.9966
Loa Loa (eye worm) myotactin form A 0.0305 0.1629 0.4783
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.33 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0602 0.33 0.3293
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0602 0.33 0.9968
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0123 0.0113
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0602 0.33 0.9966
Brugia malayi hypothetical protein 0.0305 0.1629 0.471
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0602 0.33 0.9719
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.001 0.0021
Echinococcus granulosus tyrosine protein kinase Fyn 0.0602 0.33 0.6566
Brugia malayi Calcitonin receptor-like protein seb-1 0.0193 0.0997 0.2815
Entamoeba histolytica tyrosine kinase, putative 0.0602 0.33 0.9966
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Giardia lamblia Kinase, NEK 0.0602 0.33 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0602 0.33 0.971
Echinococcus multilocularis tyrosine protein kinase csk 0.0602 0.33 0.3293
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0907 0.5021 1
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis roundabout 2 0.0305 0.1629 0.1621
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0265 0.0255
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0602 0.33 0.6566
Leishmania major hypothetical protein, conserved 0.0602 0.33 0.997
Trichomonas vaginalis protein tyrosine kinase, putative 0.0602 0.33 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.1629 0.471
Echinococcus granulosus activated cdc42 kinase 1 0.0602 0.33 0.6566
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Echinococcus granulosus tyrosine protein kinase csk 0.0602 0.33 0.6566
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0305 0.1629 0.4922
Loa Loa (eye worm) hypothetical protein 0.0602 0.33 0.9719
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0323
Echinococcus multilocularis protein kinase 0.0602 0.33 0.3293
Schistosoma mansoni protein tyrosine kinase 0.0602 0.33 0.6573
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0305 0.1629 0.1621
Schistosoma mansoni ephrin receptor 0.0602 0.33 0.6573
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Loa Loa (eye worm) hypothetical protein 0.0305 0.1629 0.4783
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Echinococcus multilocularis heat shock protein 70 0.0602 0.33 0.3293
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Schistosoma mansoni tyrosine kinase 0.0602 0.33 0.6573
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Loa Loa (eye worm) TK/FER protein kinase 0.0602 0.33 0.9719
Mycobacterium leprae conserved hypothetical protein 0.0037 0.012 0.5
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Schistosoma mansoni transcription factor LCR-F1 0.008 0.036 0.0717
Entamoeba histolytica protein kinase, putative 0.0602 0.33 0.9966
Echinococcus granulosus receptor type guanylyl cyclase 0.0602 0.33 0.6566
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0061 0.0253 0.0243
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0305 0.1629 0.1621
Echinococcus granulosus tyrosine protein kinase Blk 0.0602 0.33 0.6566
Trichomonas vaginalis TKL family protein kinase 0.0602 0.33 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0602 0.33 0.9719
Brugia malayi Protein kinase domain containing protein 0.0602 0.33 0.9715
Schistosoma mansoni serine/threonine protein kinase 0.0619 0.3395 0.6762
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0014 0.0011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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