Detailed information for compound 1836367

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 487.009 | Formula: C22H31ClN2O6S
  • H donors: 0 H acceptors: 4 LogP: 3.57 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC(CC1)CCOC(=O)N1CCc2c1c(Cl)cc(c2)S(=O)(=O)C)OC(C)(C)C
  • InChi: 1S/C22H31ClN2O6S/c1-22(2,3)31-20(26)24-9-5-15(6-10-24)8-12-30-21(27)25-11-7-16-13-17(32(4,28)29)14-18(23)19(16)25/h13-15H,5-12H2,1-4H3
  • InChiKey: MPXXJUZQJQZAEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens G protein-coupled receptor 119 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor G protein-coupled receptor 119 335 aa 274 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia NADH oxidase lateral transfer candidate 0.0058 0.0055 0.1057
Echinococcus granulosus dnaJ subfamily B 0.2276 0.3688 0.3684
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0035 0.0029
Onchocerca volvulus 0.0214 0.0312 0.1422
Brugia malayi PHD-finger family protein 0.0124 0.0164 0.0605
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0043 0.0388
Trichomonas vaginalis glutaminase, putative 0.0291 0.0438 0.1952
Loa Loa (eye worm) hypothetical protein 0.006 0.0059 0.0203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0201 0.0291 0.0286
Echinococcus multilocularis PHD finger protein rhinoceros 0.0068 0.0072 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0092 0.1339
Trypanosoma brucei unspecified product 0.0045 0.0035 0.0237
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0385 0.0591 0.2228
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0058 0.0055 0.2273
Brugia malayi Pre-SET motif family protein 0.0172 0.0243 0.0904
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0058 0.0055 0.0631
Brugia malayi F/Y-rich N-terminus family protein 0.0086 0.0101 0.0365
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0066 0.0068 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0035 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0261 0.1126
Echinococcus granulosus dna polymerase eta 0.0095 0.0117 0.0112
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0073 0.0258
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0092 0.1339
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0035 0.0111
Brugia malayi Latrophilin receptor protein 2 0.0122 0.016 0.059
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.1633 0.2635 1
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.0117 0.0425
Echinococcus granulosus tar DNA binding protein 0.0069 0.0073 0.0068
Echinococcus multilocularis musashi 0.0031 0.0012 0.0007
Schistosoma mansoni hypothetical protein 0.038 0.0583 0.0578
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0066 0.0068 0.0063
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0023 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.0233 0.4096
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.008 0.0092 0.0642
Loa Loa (eye worm) hypothetical protein 0.006 0.0059 0.0203
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0035 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0201 0.0291 0.1085
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0217 0.0212
Brugia malayi beta-NAC-like protein 0.0038 0.0023 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0351 0.0536 1
Brugia malayi jmjC domain containing protein 0.0222 0.0324 0.1214
Echinococcus multilocularis dna polymerase kappa 0.0066 0.0068 0.0063
Trypanosoma cruzi trypanothione reductase, putative 0.0166 0.0233 0.4098
Brugia malayi latrophilin 2 splice variant baaae 0.0263 0.0392 0.147
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0092 0.2842
Echinococcus granulosus zinc finger protein 0.01 0.0125 0.012
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0035 0.0111
Giardia lamblia Kinase, PLK 0.0212 0.0308 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0422 0.0651 1
Echinococcus granulosus tumor protein p63 0.1465 0.2359 0.2355
Trypanosoma brucei polo-like protein kinase 0.0212 0.0308 0.5552
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0308 0.1344
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0163 0.0227 0.0222
Schistosoma mansoni thyroid hormone receptor 0.0191 0.0274 0.0269
Loa Loa (eye worm) hypothetical protein 0.008 0.0092 0.0328
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0351 0.0536 1
Echinococcus multilocularis zinc finger protein 0.01 0.0125 0.012
Trypanosoma brucei ISWI complex protein 0.0068 0.0073 0.0977
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0042 0.003 0.0095
Loa Loa (eye worm) hypothetical protein 0.0068 0.0072 0.0254
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0193 0.0188
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0202 0.0292 0.0287
Leishmania major mitochondrial DNA polymerase beta 0.0351 0.0536 1
Schistosoma mansoni cpg binding protein 0.0177 0.0251 0.0246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0055 0.0631
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0064 0.0065 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0068 0.0072 0.0067
Entamoeba histolytica acyl-coA synthetase, putative 0.008 0.0092 0.2842
Mycobacterium ulcerans glutaminase 0.0291 0.0438 1
Trypanosoma cruzi trypanothione reductase, putative 0.0058 0.0055 0.0631
Echinococcus multilocularis dnaJ subfamily B 0.2276 0.3688 0.3684
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0222 0.0324 0.0319
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0035 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0035 0.0237
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0042 0.0368
Schistosoma mansoni DNA polymerase eta 0.0095 0.0117 0.0112
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0217 0.0212
Plasmodium vivax acyl-CoA synthetase, putative 0.006 0.0059 0.2409
Brugia malayi Pre-SET motif family protein 0.1181 0.1894 0.7182
Echinococcus multilocularis lysine specific demethylase 5A 0.0082 0.0095 0.009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0046 0.0036 0.0031
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0066 0.0068 0.0063
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0032 0.0013 0.0324
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0073 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0035 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0201 0.0291 0.0286
Mycobacterium tuberculosis Probable oxidoreductase 0.0422 0.0651 1
Schistosoma mansoni bromodomain containing protein 0.0296 0.0445 0.044
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.008 0.0092 0.095
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0023 0.0941
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0878 0.1398 0.1394
Brugia malayi steroid hormone receptor 0.0045 0.0035 0.0111
Entamoeba histolytica hypothetical protein 0.0202 0.0292 0.9467
Echinococcus multilocularis thyroid hormone receptor alpha 0.0191 0.0274 0.0269
Toxoplasma gondii exonuclease III APE 0.0064 0.0065 0.0906
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0058 0.0055 0.2176
Trypanosoma brucei unspecified product 0.0066 0.0068 0.0888
Toxoplasma gondii PHD-finger domain-containing protein 0.0068 0.0072 0.105
Schistosoma mansoni bromodomain containing protein 0.0032 0.0013 0.0008
Echinococcus granulosus intermediate filament protein 0.0031 0.0012 0.0007
Brugia malayi SET domain containing protein 0.0027 0.0006 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0013 0.003
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0023 0.0752
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.0117 0.1833
Onchocerca volvulus Alhambra homolog 0.0068 0.0072 0.0307
Echinococcus granulosus fetal alzheimer antigen falz 0.011 0.0141 0.0136
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0058 0.0055 0.0631
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0058 0.0055 0.005
Plasmodium vivax hypothetical protein, conserved 0.0068 0.0072 0.2959
Leishmania major hypothetical protein, conserved 0.0068 0.0073 0.0977
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0058 0.0055 0.0631
Mycobacterium ulcerans fatty-acid-CoA ligase 0.006 0.0059 0.0087
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0064 0.0065 0.1968
Mycobacterium ulcerans hypothetical protein 0.0185 0.0264 0.5449
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0212 0.0308 0.5552
Trypanosoma cruzi polo-like protein kinase, putative 0.0212 0.0308 0.5552
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0201 0.0291 0.0286
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0379 0.0582 0.8762
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0035 0.0029
Mycobacterium ulcerans DNA polymerase IV 0.0066 0.0068 0.0345
Toxoplasma gondii histone lysine methyltransferase SET1 0.0323 0.049 1
Echinococcus multilocularis dna polymerase eta 0.0095 0.0117 0.0112
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0035 0.0029
Loa Loa (eye worm) hypothetical protein 0.0045 0.0035 0.0111
Toxoplasma gondii NADPH-glutathione reductase 0.0058 0.0055 0.0693
Trichomonas vaginalis mercuric reductase, putative 0.0058 0.0055 0.0164
Schistosoma mansoni hypothetical protein 0.0263 0.0392 0.0387
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0055 0.0631
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0023 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0261 0.1126
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.1633 0.2635 0.2631
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.1633 0.2635 0.2631
Loa Loa (eye worm) hypothetical protein 0.0095 0.0117 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0035 0.0111
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0035 0.0029
Loa Loa (eye worm) hypothetical protein 0.0045 0.0035 0.0111
Mycobacterium tuberculosis Probable reductase 0.0379 0.0582 0.8841
Loa Loa (eye worm) hypothetical protein 0.004 0.0026 0.0079
Echinococcus granulosus mixed lineage leukemia protein mll 0.0046 0.0036 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0419 0.1862
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0201 0.0291 0.1085
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Loa Loa (eye worm) hypothetical protein 0.006 0.0059 0.0203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0035 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0058 0.0055 0.0631
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.004 0.0026 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0059 0.0713
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0419 0.1862
Giardia lamblia DINP protein human, muc B family 0.0066 0.0068 0.1524
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0202 0.0292 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0035 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0249 0.0368 0.0363
Brugia malayi MH2 domain containing protein 0.0397 0.0611 0.2305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0201 0.0291 0.0286
Schistosoma mansoni hypothetical protein 0.0068 0.0072 0.0067
Schistosoma mansoni cpg binding protein 0.016 0.0223 0.0217
Loa Loa (eye worm) hypothetical protein 0.0385 0.0591 0.2228
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.006 0.0059 1
Schistosoma mansoni ap endonuclease 0.0064 0.0065 0.006
Entamoeba histolytica hypothetical protein 0.0038 0.0023 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0035 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.004 0.0026 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.0124 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0023 0.0013
Schistosoma mansoni lamin 0.0031 0.0012 0.0007
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0422 0.0651 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0222 0.0324 0.0319
Schistosoma mansoni hypothetical protein 0.038 0.0583 0.0578
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0072 0.0067
Plasmodium falciparum phd finger protein, putative 0.0068 0.0072 0.2909
Leishmania major trypanothione reductase 0.0166 0.0233 0.4098
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0013 0.0541
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0049 0.0043
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0024 0.0073
Schistosoma mansoni methyl-cpg binding protein mbd 0.0076 0.0086 0.0081
Echinococcus granulosus geminin 0.038 0.0583 0.0578
Loa Loa (eye worm) glutaminase 2 0.0291 0.0438 0.1645
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0058 0.0055 0.0631
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0035 0.0029
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0035 0.0029
Echinococcus multilocularis GPCR, family 2 0.0122 0.016 0.0155
Trypanosoma brucei unspecified product 0.0045 0.0035 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Echinococcus granulosus jumonji domain containing protein 0.0094 0.0115 0.011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0172 0.0243 0.0238
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0035 0.0111
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0046 0.0036 0.0031
Entamoeba histolytica serine/threonine protein kinase, putative 0.0212 0.0308 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.0124 0.0119
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0166 0.0233 0.3009
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0058 0.0055 0.0631
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0064 0.0065 0.006
Schistosoma mansoni cellular tumor antigen P53 0.0214 0.0312 0.0307
Treponema pallidum exodeoxyribonuclease (exoA) 0.0064 0.0065 1
Onchocerca volvulus 0.1343 0.216 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0073 0.0068
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0308 0.1344
Brugia malayi Calcitonin receptor-like protein seb-1 0.0385 0.0591 0.2228
Loa Loa (eye worm) hypothetical protein 0.0214 0.0312 0.1167
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Schistosoma mansoni thyroid hormone receptor 0.0191 0.0274 0.0269
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0122 0.016 0.0155
Plasmodium falciparum thioredoxin reductase 0.0058 0.0055 0.2176
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0068 0.0888
Brugia malayi serine/threonine-protein kinase plk-2 0.0212 0.0308 0.115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0345 0.0526 0.0521
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0308 0.1344
Echinococcus multilocularis thioredoxin glutathione reductase 0.0168 0.0237 0.0232
Loa Loa (eye worm) hypothetical protein 0.0045 0.0035 0.0111
Loa Loa (eye worm) CXXC zinc finger family protein 0.016 0.0223 0.0827
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0277 0.1202
Mycobacterium ulcerans fatty-acid-CoA ligase 0.008 0.0092 0.095
Entamoeba histolytica deoxycytidyl transferase, putative 0.0066 0.0068 0.2075
Loa Loa (eye worm) jmjC domain-containing protein 0.014 0.019 0.0703
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.0233 0.4096
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.0201 0.0195
Echinococcus multilocularis peregrin 0.0082 0.0095 0.009
Brugia malayi Bromodomain containing protein 0.0082 0.0095 0.0342
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0201 0.0291 0.0286
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0261 0.1126
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0066 0.0068 0.024
Onchocerca volvulus 0.0031 0.0012 0.003
Entamoeba histolytica hypothetical protein 0.0202 0.0292 0.9467
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0073 0.0068
Onchocerca volvulus Serine\/threonine kinase homolog 0.0212 0.0308 0.1402
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0161 0.0224 0.0219
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0055 0.0631
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0035 0.0029
Loa Loa (eye worm) histone methyltransferase 0.0056 0.0052 0.0178
Echinococcus granulosus peregrin 0.0082 0.0095 0.009
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0035 0.0029
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0023 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0035 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0308 0.1344
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.1633 0.2635 0.2631
Echinococcus granulosus methyl CpG binding domain protein 2 0.0076 0.0086 0.0081
Echinococcus multilocularis lamin 0.0031 0.0012 0.0007
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0023 0.0566
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0172 0.0243 0.4713
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1181 0.1894 0.7182
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0025 0.065
Brugia malayi ecdysteroid receptor 0.0045 0.0035 0.0111
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0164 0.0229 0.085
Loa Loa (eye worm) hypothetical protein 0.0172 0.0242 0.0901
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.028 0.0419 0.1572
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0419 0.1862
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0068 0.0888
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0023 0.0003
Plasmodium falciparum glutathione reductase 0.0166 0.0233 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0023 0.057
Schistosoma mansoni transcription factor btf3 0.0038 0.0023 0.0018
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0058 0.0055 0.2176
Onchocerca volvulus 0.0164 0.0229 0.1035
Loa Loa (eye worm) hypothetical protein 0.006 0.0059 0.0203
Toxoplasma gondii ImpB/MucB/SamB family protein 0.005 0.0043 0.0426
Loa Loa (eye worm) glutaminase 0.0291 0.0438 0.1645
Loa Loa (eye worm) glutathione reductase 0.0166 0.0233 0.0867
Leishmania major DNA polymerase eta, putative 0.0095 0.0117 0.1833
Trichomonas vaginalis glutathione reductase, putative 0.0058 0.0055 0.0164
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0122 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0186 0.0265 0.0989
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0012 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0261 0.1126
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0049 0.0551
Brugia malayi jmjC domain containing protein 0.01 0.0124 0.0452
Schistosoma mansoni hypothetical protein 0.0202 0.0292 0.0287
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0023 0.0002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0076 0.0086 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0261 0.1126
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0092 0.1339
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0035 0.0029
Echinococcus multilocularis cpg binding protein 0.0177 0.0251 0.0246
Loa Loa (eye worm) hypothetical protein 0.008 0.0092 0.0328
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.011 0.0141 0.0136
Echinococcus granulosus transcription factor btf3 0.0038 0.0023 0.0018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0064 0.0065 0.006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0035 0.0029
Echinococcus granulosus GPCR family 2 0.0122 0.016 0.0155
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Entamoeba histolytica hypothetical protein 0.0202 0.0292 0.9467
Schistosoma mansoni hypothetical protein 0.0068 0.0073 0.0068
Brugia malayi Bromodomain containing protein 0.0348 0.0531 0.2
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0064 0.0065 0.0825
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0212 0.0308 0.115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0035 0.0111
Brugia malayi TAR-binding protein 0.0069 0.0073 0.0258
Echinococcus granulosus cpg binding protein 0.0177 0.0251 0.0246
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0066 0.0068 0.0063
Echinococcus granulosus expressed protein 0.0039 0.0024 0.0019
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0023 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0012 0.0027
Onchocerca volvulus 0.016 0.0223 0.1007
Leishmania major DNA polymerase eta, putative 0.005 0.0043 0.0388
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0035 0.0029
Mycobacterium ulcerans hypothetical protein 0.008 0.0092 0.095
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0035 0.0237
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0035 0.0029
Loa Loa (eye worm) hypothetical protein 0.0045 0.0035 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0172 0.0243 0.0238
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0249 0.0368 0.0363
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.008 0.0092 0.095
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0064 0.0065 0.0228
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.008 0.0092 0.095
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0092 0.095
Echinococcus granulosus lysine specific demethylase 5A 0.01 0.0124 0.0119
Trypanosoma cruzi polo-like protein kinase, putative 0.0212 0.0308 0.5552
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0035 0.0111
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0161 0.0224 0.0219
Loa Loa (eye worm) transcription factor SMAD2 0.0397 0.0611 0.2305
Plasmodium falciparum acyl-CoA synthetase 0.006 0.0059 0.2321
Loa Loa (eye worm) latrophilin receptor protein 2 0.0122 0.016 0.059
Brugia malayi nuclear receptor NHR-88 0.0045 0.0035 0.0111
Schistosoma mansoni hypothetical protein 0.0122 0.016 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0035 0.0111
Echinococcus multilocularis expressed protein 0.0039 0.0024 0.0019
Loa Loa (eye worm) acetyltransferase 0.0157 0.0217 0.0807
Loa Loa (eye worm) hypothetical protein 0.021 0.0305 0.1138
Echinococcus multilocularis lamin dm0 0.0031 0.0012 0.0007
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0058 0.0055 0.0693
Plasmodium falciparum glutathione reductase 0.0058 0.0055 0.2176
Schistosoma mansoni hypothetical protein 0.0146 0.0201 0.0195
Loa Loa (eye worm) hypothetical protein 0.0122 0.016 0.059
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0068 0.0888
Loa Loa (eye worm) MH2 domain-containing protein 0.0397 0.0611 0.2305
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0024 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0035 0.0111
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0058 0.0055 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0055 0.0631
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0042 0.0368
Loa Loa (eye worm) hypothetical protein 0.0249 0.0368 0.138
Schistosoma mansoni rotamase 0.0039 0.0024 0.0019
Toxoplasma gondii PHD-finger domain-containing protein 0.0068 0.0072 0.105
Loa Loa (eye worm) hypothetical protein 0.0116 0.0151 0.0555
Schistosoma mansoni hypothetical protein 0.0122 0.016 0.0155
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0012 0.0027
Loa Loa (eye worm) bromodomain containing protein 0.0083 0.0096 0.0346
Brugia malayi intermediate filament protein 0.0031 0.0012 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0308 0.1344
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0042 0.0368
Brugia malayi exodeoxyribonuclease III family protein 0.0064 0.0065 0.0228
Loa Loa (eye worm) hypothetical protein 0.1633 0.2635 1
Echinococcus granulosus lamin dm0 0.0031 0.0012 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0066 0.0068 0.0888
Brugia malayi CXXC zinc finger family protein 0.016 0.0223 0.0827
Trypanosoma cruzi ISWI complex protein 0.0068 0.0073 0.0977
Onchocerca volvulus 0.0031 0.0012 0.003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0058 0.0055 0.0631
Schistosoma mansoni hypothetical protein 0.0122 0.016 0.0155
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.028 0.0419 0.0414
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0419 0.1862
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0201 0.0291 0.0286
Entamoeba histolytica hypothetical protein 0.0202 0.0292 0.9467
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0035 0.0237
Mycobacterium ulcerans DNA polymerase IV 0.0066 0.0068 0.0345
Schistosoma mansoni jumonji domain containing protein 0.0176 0.025 0.0245
Loa Loa (eye worm) hypothetical protein 0.0045 0.0035 0.0111
Echinococcus multilocularis transcription factor btf3 0.0038 0.0023 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0261 0.1126
Loa Loa (eye worm) hypothetical protein 0.0045 0.0035 0.0111
Brugia malayi Thioredoxin reductase 0.0166 0.0233 0.0867
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0419 0.1862
Trichomonas vaginalis rotamase, putative 0.0039 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0035 0.0111
Schistosoma mansoni myst-related protein 0.0027 0.0006 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0035 0.0111
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0212 0.0308 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0035 0.0111
Echinococcus granulosus lamin 0.0031 0.0012 0.0007
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0049 0.0551
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0212 0.0308 0.0303
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0064 0.0065 0.141
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.0117 0.1833
Schistosoma mansoni terminal deoxycytidyl transferase 0.0066 0.0068 0.0063
Schistosoma mansoni hypothetical protein 0.0092 0.0112 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0073 0.0258
Brugia malayi glutaminase DH11.1 0.0291 0.0438 0.1645
Schistosoma mansoni zinc finger protein 0.0068 0.0073 0.0068
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0379 0.0582 0.8841
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.028 0.0419 0.0414
Brugia malayi PHD-finger family protein 0.0068 0.0072 0.0254
Mycobacterium tuberculosis Probable dehydrogenase 0.0379 0.0582 0.8841
Schistosoma mansoni kinase 0.0108 0.0137 0.0132
Schistosoma mansoni hypothetical protein 0.2276 0.3688 0.3684
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0024 0.0073
Echinococcus granulosus thioredoxin glutathione reductase 0.0168 0.0237 0.0232
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0042 0.003 0.0095
Trichomonas vaginalis set domain proteins, putative 0.1343 0.216 1
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0035 0.0134
Trichomonas vaginalis DNA polymerase eta, putative 0.0066 0.0068 0.0225
Loa Loa (eye worm) hypothetical protein 0.0263 0.0392 0.147
Echinococcus multilocularis fetal alzheimer antigen, falz 0.011 0.0141 0.0136
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.021 0.0305 0.1387
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0035 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0055 0.0631
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0035 0.0029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0064 0.0065 0.0825
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0049 0.0133
Schistosoma mansoni coup transcription factor 0.0045 0.0035 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0035 0.0111
Schistosoma mansoni intermediate filament proteins 0.0031 0.0012 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0049 0.0133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0035 0.0029
Echinococcus multilocularis tumor protein p63 0.1465 0.2359 0.2355
Schistosoma mansoni cpg binding protein 0.0177 0.0251 0.0246
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0064 0.0065 0.026
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0064 0.0065 0.0825
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0058 0.0055 0.2273
Echinococcus multilocularis jumonji domain containing protein 0.0094 0.0115 0.011
Schistosoma mansoni ap endonuclease 0.0064 0.0065 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Trichomonas vaginalis rotamase, putative 0.0038 0.0023 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0035 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0035 0.0111
Echinococcus granulosus PHD finger protein rhinoceros 0.0068 0.0072 0.0067
Trypanosoma brucei trypanothione reductase 0.0166 0.0233 0.4098
Brugia malayi AMP-binding enzyme family protein 0.008 0.0092 0.0328
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0422 0.0651 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0023 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0202 0.0292 0.0287
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0133 0.0525
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0035 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0133 0.0525
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0172 0.0243 0.0238
Toxoplasma gondii thioredoxin reductase 0.0166 0.0233 0.4501
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.0201 0.0195
Brugia malayi AMP-binding enzyme family protein 0.008 0.0092 0.0328
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0065 0.2683
Leishmania major DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0058 0.0055 0.0631
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0351 0.0536 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0064 0.0065 0.02
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0009 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.0308 0.0303
Onchocerca volvulus 0.008 0.0092 0.0399
Brugia malayi glutathione reductase 0.0166 0.0233 0.0867
Brugia malayi PHD-finger family protein 0.004 0.0026 0.0079
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0073 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0092 0.0642
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0385 0.0591 0.2228
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0035 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0249 0.0368 0.0363
Brugia malayi Bromodomain containing protein 0.0175 0.0247 0.0921
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0035 0.0111
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0068 0.0254
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0035 0.0111
Loa Loa (eye worm) hypothetical protein 0.0317 0.0479 0.1802
Schistosoma mansoni lamin 0.0031 0.0012 0.0007
Plasmodium vivax SET domain protein, putative 0.0172 0.0243 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0073 0.0258
Plasmodium falciparum thioredoxin reductase 0.0166 0.0233 1
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0419 0.1862
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0035 0.0029
Toxoplasma gondii hypothetical protein 0.0057 0.0054 0.0659
Schistosoma mansoni zinc finger protein 0.01 0.0125 0.012
Echinococcus granulosus histone lysine methyltransferase setb 0.0249 0.0368 0.0363
Loa Loa (eye worm) hypothetical protein 0.006 0.0059 0.0203
Brugia malayi RNA binding protein 0.0069 0.0073 0.0258
Loa Loa (eye worm) RNA binding protein 0.0069 0.0073 0.0258
Onchocerca volvulus 0.0172 0.0243 0.1102
Brugia malayi nuclear hormone receptor 0.0045 0.0035 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0308 0.1344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0035 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0073 0.0068
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0379 0.0582 0.8841
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.028 0.0419 0.1572
Mycobacterium tuberculosis Conserved hypothetical protein 0.0185 0.0264 0.3521
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0058 0.0055 0.0631
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.0261 0.1186
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0379 0.0582 0.8841
Brugia malayi hypothetical protein 0.0202 0.0292 0.1089
Loa Loa (eye worm) PHD-finger family protein 0.0092 0.0112 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0201 0.0291 0.0286
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0058 0.0055 0.019
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0056 0.0052 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0035 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0308 0.1344
Loa Loa (eye worm) PHD-finger family protein 0.0068 0.0072 0.0254
Trypanosoma cruzi ISWI complex protein 0.0068 0.0073 0.0977
Loa Loa (eye worm) hypothetical protein 0.008 0.0092 0.0328
Brugia malayi AMP-binding enzyme family protein 0.008 0.0092 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0035 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Schistosoma mansoni glutaminase 0.0291 0.0438 0.0433
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0025 0.0863
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0058 0.0055 0.0631
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0068 0.024
Schistosoma mansoni methyl-cpg binding protein mbd 0.0076 0.0086 0.0081
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0046 0.0036 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0092 0.095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0122 0.016 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0035 0.0029
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0066 0.0068 0.0225
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.0233 0.4096
Schistosoma mansoni hypothetical protein 0.0122 0.016 0.0155
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0035 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0092 0.2842
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0065 0.2614
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0035 0.0111
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0035 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0035 0.0111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0056 0.0052 0.0047
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0379 0.0582 0.8841
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0035 0.0029
Loa Loa (eye worm) hypothetical protein 0.0045 0.0035 0.0111
Plasmodium vivax thioredoxin reductase, putative 0.0166 0.0233 0.9591
Plasmodium vivax glutathione reductase, putative 0.0166 0.0233 0.9591
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0122 0.016 0.059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0064 0.0065 0.0825
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0073 0.0068
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0049 0.2
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0277 0.1202
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0217 0.0807
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0065 0.021
Echinococcus granulosus dna polymerase kappa 0.0066 0.0068 0.0063
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0035 0.0134
Loa Loa (eye worm) jmjC domain-containing protein 0.01 0.0124 0.0452
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0092 0.095
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0058 0.0055 0.0631
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0068 0.0888
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0058 0.0055 0.005
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0058 0.0055 0.005
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.006 0.0059 0.0089
Onchocerca volvulus 0.0045 0.0035 0.0134
Loa Loa (eye worm) hypothetical protein 0.0204 0.0294 0.1099
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0122 0.016 0.0155
Brugia malayi N-terminal motif family protein 0.021 0.0305 0.1138
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0261 0.1126
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0042 0.0368
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0065 0.021
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0035 0.0029
Loa Loa (eye worm) thioredoxin reductase 0.0166 0.0233 0.0867
Giardia lamblia PHD finger protein 15 0.0068 0.0072 0.1648
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0035 0.0029
Schistosoma mansoni myst-related protein 0.0027 0.0006 0.0001
Brugia malayi hypothetical protein 0.0164 0.0229 0.085
Echinococcus multilocularis geminin 0.038 0.0583 0.0578

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 21 nM Agonist activity at human GPR119 transfected in CHO cells assessed as cAMP accumulation after 2 hrs by luciferase reporter gene assay ChEMBL. 24508142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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