Detailed information for compound 1863530

Basic information

Technical information
  • TDR Targets ID: 1863530
  • Name: N-tridecylpiperidin-4-amine dihydrochloride
  • MW: 355.43 | Formula: C18H40Cl2N2
  • H donors: 2 H acceptors: 0 LogP: 7.65 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCNC1CCNCC1.Cl.Cl
  • InChi: 1S/C18H38N2.2ClH/c1-2-3-4-5-6-7-8-9-10-11-12-15-20-18-13-16-19-17-14-18;;/h18-20H,2-17H2,1H3;2*1H
  • InChiKey: CSAOYVCWOYRRTO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-tridecyl-4-piperidinamine dihydrochloride
  • 4-piperidyl-tridecyl-amine dihydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni trimeric G-protein alpha o subunit Get druggable targets OG5_126802 All targets in OG5_126802
Candida albicans G-protein alpha subunit capable of functional substitution for S. cerevisiae GPA1 (YHR005C) component of pheromone response path Get druggable targets OG5_126802 All targets in OG5_126802
Entamoeba histolytica G protein alpha subunit, putative Get druggable targets OG5_126802 All targets in OG5_126802
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126802 All targets in OG5_126802
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative Get druggable targets OG5_126802 All targets in OG5_126802
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 Get druggable targets OG5_126802 All targets in OG5_126802
Echinococcus granulosus guanine nucleotide binding protein G protein Get druggable targets OG5_126802 All targets in OG5_126802
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative Get druggable targets OG5_126802 All targets in OG5_126802
Candida albicans similar to G-alpha protein, glucose-induced activation of plasma membrane ATPase Get druggable targets OG5_126802 All targets in OG5_126802
Echinococcus granulosus gtp binding protein I alpha 1subunit Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma japonicum Guanine nucleotide-binding protein G(i) subunit alpha, putative Get druggable targets OG5_126802 All targets in OG5_126802
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit Get druggable targets OG5_126802 All targets in OG5_126802
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma japonicum Guanine nucleotide-binding protein G(i) subunit alpha, putative Get druggable targets OG5_126802 All targets in OG5_126802
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative Get druggable targets OG5_126802 All targets in OG5_126802
Echinococcus granulosus guanine nucleotide binding protein G protein Get druggable targets OG5_126802 All targets in OG5_126802
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma japonicum Guanine nucleotide-binding protein G(i) subunit alpha, putative Get druggable targets OG5_126802 All targets in OG5_126802
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126802 All targets in OG5_126802
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126802 All targets in OG5_126802
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative Get druggable targets OG5_126802 All targets in OG5_126802
Candida albicans likely G-protein alpha subunit capable of functional substitution for S. cerevisiae GPA1 (YHR005C) component of pheromone respon Get druggable targets OG5_126802 All targets in OG5_126802
Echinococcus multilocularis guanine nucleotide binding protein (G protein) Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 Get druggable targets OG5_126802 All targets in OG5_126802
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma japonicum Guanine nucleotide-binding protein G(i) subunit alpha, putative Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma japonicum ko:K04534 guanine nucleotide binding protein (G protein), alpha o polypeptide, putative Get druggable targets OG5_126802 All targets in OG5_126802
Loa Loa (eye worm) heterotrimeric G protein alpha subunit Get druggable targets OG5_126802 All targets in OG5_126802
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative Get druggable targets OG5_126802 All targets in OG5_126802
Candida albicans similar to G-alpha protein, glucose-induced activation of plasma membrane ATPase Get druggable targets OG5_126802 All targets in OG5_126802
Schistosoma japonicum Guanine nucleotide-binding protein G(i) subunit alpha-1, putative Get druggable targets OG5_126802 All targets in OG5_126802
Echinococcus multilocularis guanine nucleotide binding protein (G protein) Get druggable targets OG5_126802 All targets in OG5_126802
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 354 aa 356 aa 50.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0012 0.0042
Schistosoma mansoni smad1 5 8 and 0.0033 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0019
Echinococcus multilocularis muscleblind protein 1 0.0298 0.0206 0.0731
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0012 0.0012
Trypanosoma brucei cyclophilin a 0.0044 0.0021 0.0076
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0217 0.0147 0.0608
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0687 0.0488 0.1735
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.1577 0.1134 0.4795
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0014 0.0014
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0028 0.001 0.0036
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1278 0.0917 0.3258
Mycobacterium ulcerans hypothetical protein 0.0143 0.0094 0.0382
Brugia malayi MH2 domain containing protein 0.0033 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0212 0.0143 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.1647 0.1185 0.1185
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0217 0.0147 0.0608
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0012 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0027 0.0026
Schistosoma mansoni phosphoglucomutase 0.0021 0.0005 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0217 0.0147 0.1571
Giardia lamblia Kinase, PLK 0.0071 0.0042 0.2603
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1278 0.0917 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Loa Loa (eye worm) peptidase family M13 containing protein 0.1609 0.1157 0.1157
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.0489 0.1738
Trypanosoma cruzi 21 kDa cyclophilin, putative 0.0044 0.0021 0.0072
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0003
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0398 0.0278 0.0989
Onchocerca volvulus 0.0048 0.0024 0.031
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.0019 0.0066
Echinococcus granulosus lamin 0.0024 0.0007 0.0025
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0012 0.0045
Brugia malayi Muscleblind-like protein 0.0298 0.0206 0.0206
Schistosoma mansoni peroxidasin 0.0026 0.0009 0.003
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.3272 0.2364 1
Onchocerca volvulus 0.0155 0.0102 0.1316
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0012 0.0042
Schistosoma mansoni hypothetical protein 0.0074 0.0044 0.0155
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0019 0.0004 0.0013
Brugia malayi Peroxidasin 0.0026 0.0009 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0217 0.0147 0.0147
Schistosoma mansoni peroxidasin 0.0026 0.0009 0.003
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0012 0.0042
Brugia malayi Latrophilin receptor protein 2 0.0113 0.0072 0.0072
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0012 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0019 0.0004 0.0004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0002 0.0004
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.3272 0.2364 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0005 0.0016
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0003 0.0008
Leishmania major ribonuclease H1, putative 0.0021 0.0005 0.0015
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0019 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Trypanosoma brucei heat shock protein, putative 0.0217 0.0147 0.0522
Trypanosoma cruzi cyclophilin type peptidyl-prolyl cis-trans isomerase 0.0044 0.0021 0.0072
Echinococcus multilocularis calpain family protein 1, d 0.0045 0.0023 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0019 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0012 0.0042
Treponema pallidum ribonuclease H (rnhA) 0.0021 0.0005 0.0132
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0011
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0217 0.0147 0.1898
Loa Loa (eye worm) fli-1 protein 0.0166 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Schistosoma mansoni heat shock protein 0.0217 0.0147 0.0521
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0113 0.0072 0.0254
Echinococcus multilocularis muscleblind protein 0.0298 0.0206 0.0731
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis receptor histidine kinase, putative 0.0217 0.0147 0.1571
Schistosoma mansoni Nep2 peptidase (M13 family) 0.1099 0.0787 0.2796
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0005 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Loa Loa (eye worm) apoptosis regulator protein 0.0074 0.0044 0.0044
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.3892 0.2813 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0028 0.001 0.003
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.3892 0.2813 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0028 0.001 0.0036
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-2 0.0044 0.0021 0.0021
Echinococcus granulosus Niemann Pick C1 protein 0.0288 0.0199 0.0707
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0019 0.017
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0217 0.0147 0.0521
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0028 0.001 0.0031
Brugia malayi Pre-SET motif family protein 0.0031 0.0012 0.0012
Schistosoma mansoni calpain (C02 family) 0.0019 0.0004 0.0012
Onchocerca volvulus 0.0236 0.0161 0.2079
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.0136 0.1455
Loa Loa (eye worm) Smad1 0.0033 0.0014 0.0014
Treponema pallidum DNA ligase (lig) 0.004 0.0019 0.1061
Trypanosoma cruzi kinesin, putative 0.0019 0.0004 0.0009
Loa Loa (eye worm) endoplasmin 0.0217 0.0147 0.0147
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0028 0.001 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0008 0.0019
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0687 0.0488 0.1731
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0217 0.0147 0.1571
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0053 0.0186
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0007 0.0024
Brugia malayi isocitrate dehydrogenase 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0019
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0005 0.0016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0012 0.0042
Onchocerca volvulus Serine\/threonine kinase homolog 0.0071 0.0042 0.0534
Schistosoma mansoni hypothetical protein 0.0568 0.0402 0.1428
Echinococcus multilocularis hypothetical protein 0.0019 0.0004 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0113 0.0072 0.0254
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0009 0.0111
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0619 0.0439 0.1559
Onchocerca volvulus 0.0031 0.0012 0.0151
Echinococcus multilocularis Niemann Pick C1 protein 0.0288 0.0199 0.0707
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0003 0.0009
Chlamydia trachomatis DNA gyrase subunit B 0.0217 0.0147 1
Brugia malayi Endoplasmin precursor 0.0217 0.0147 0.0147
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0568 0.0402 0.1428
Loa Loa (eye worm) hypothetical protein 0.1647 0.1185 0.1185
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0071 0.0041 0.0146
Brugia malayi Smad1 0.0033 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0044 0.0021 0.0072
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0108 0.0068 0.0255
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0028 0.001 0.007
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0687 0.0488 0.1734
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0028 0.001 0.0035
Brugia malayi CXXC zinc finger family protein 0.0048 0.0024 0.0024
Trypanosoma cruzi polo-like protein kinase, putative 0.0071 0.0042 0.0143
Mycobacterium tuberculosis Conserved protein 0.0217 0.0147 0.0616
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0009 0.0111
Trypanosoma cruzi rotamase, putative 0.0044 0.0021 0.0072
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0064 0.0036 0.0128
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0004 0.0003
Trypanosoma cruzi ribonuclease H1, putative 0.0021 0.0005 0.0015
Giardia lamblia DINP protein human, muc B family 0.002 0.0005 0.0077
Trypanosoma cruzi DNA topoisomerase II, putative 0.0217 0.0147 0.0518
Loa Loa (eye worm) hypothetical protein 0.0106 0.0067 0.0066
Brugia malayi nuclear receptor NHR-88 0.0031 0.0012 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0012 0.0042
Trypanosoma brucei heat shock protein, putative 0.0217 0.0147 0.0522
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0007 0.0024
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0009 0.0009
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Loa Loa (eye worm) hypothetical protein 0.0045 0.0023 0.0022
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0068 0.0039 0.0137
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0012 0.0042
Echinococcus multilocularis calpain A 0.0068 0.0039 0.0137
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0001 0.0003
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0217 0.0147 0.059
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.2178 0.157 0.5579
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0217 0.0147 0.1571
Mycobacterium leprae Probable two component sensor kinase MprB 0.0217 0.0147 0.059
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0212 0.0143 0.0505
Leishmania major hypothetical protein, conserved 0.0217 0.0147 0.0518
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0019 0.0063
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0113 0.0072 0.0072
Loa Loa (eye worm) phosphatidylinositol 3 0.0355 0.0247 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0028 0.001 0.0073
Entamoeba histolytica G protein alpha subunit, putative 0.0019 0.0004 0.0006
Toxoplasma gondii ATPase, AAA family protein 0.004 0.0019 0.0075
Brugia malayi RNase H family protein 0.0021 0.0005 0.0005
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0005 0.0012
Echinococcus granulosus heat shock protein 0.0217 0.0147 0.0521
Schistosoma mansoni hypothetical protein 0.0113 0.0072 0.0254
Echinococcus granulosus microtubule associated protein 2 0.0688 0.0489 0.1738
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Trypanosoma cruzi Heat shock protein 83, putative 0.0217 0.0147 0.0518
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0019 0.0004 0.0013
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0217 0.0147 0.0522
Schistosoma mansoni hypothetical protein 0.0568 0.0402 0.1428
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0027 0.0093
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0003 0.0009
Brugia malayi calpain 7 0.0019 0.0004 0.0003
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0019 0.0004 0.0004
Brugia malayi kinase, mitochondrial precursor 0.3892 0.2813 0.2813
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.017 0.0113 0.0402
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.3892 0.2813 1
Leishmania major dihydroorotate dehydrogenase 0.3272 0.2364 0.84
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0007 0.0024
Schistosoma mansoni cpg binding protein 0.005 0.0026 0.0092
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0009 0.0009
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.1361 0.0977 0.3472
Brugia malayi hypothetical protein 0.0026 0.0009 0.0009
Toxoplasma gondii heat shock protein 90, putative 0.0217 0.0147 0.0616
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0074 0.0044 0.0155
Trypanosoma cruzi heat shock protein 85, putative 0.0217 0.0147 0.0518
Schistosoma mansoni coup transcription factor 0.0031 0.0012 0.0042
Leishmania major mitochondrial DNA polymerase beta 0.0272 0.0187 0.066
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0028 0.001 0.0031
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0005 0.0005
Echinococcus multilocularis GPCR, family 2 0.0113 0.0072 0.0254
Schistosoma mansoni heat shock protein 0.0217 0.0147 0.0521
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0009 0.0009
Brugia malayi Zinc finger, C2H2 type family protein 0.1278 0.0917 0.0916
Echinococcus multilocularis heat shock protein 90 0.0217 0.0147 0.0521
Schistosoma mansoni gabp alpha 0.0055 0.003 0.0104
Echinococcus granulosus dna polymerase kappa 0.002 0.0005 0.0015
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0217 0.0147 0.1571
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0028 0.001 0.0034
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0398 0.0278 0.0989
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0009 0.0009
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0008 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0008 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0012 0.0042
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0019 0.017
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0053 0.0052
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1278 0.0917 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0027 0.0093
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0005 0.0012
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.2178 0.157 0.1569
Schistosoma mansoni hypothetical protein 0.0568 0.0402 0.1428
Echinococcus multilocularis lysine specific demethylase 5A 0.0044 0.0022 0.0077
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0039 0.0137
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0074 0.0044 0.0155
Loa Loa (eye worm) nuclear factor I 0.0018 0.0003 0.0003
Brugia malayi calpain 5 0.0019 0.0004 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0019 0.017
Leishmania major phosphatidylinositol 3-kinase, putative 0.0028 0.001 0.003
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0074 0.0044 0.0155
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0012 0.0042
Schistosoma mansoni pyruvate dehydrogenase 0.3892 0.2813 1
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0012 0.0042
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0108 0.0068 0.0283
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0009 0.0009
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0014 0.0049
Mycobacterium tuberculosis Probable two component sensor kinase 0.0217 0.0147 0.0616
Toxoplasma gondii DNA topoisomerase 2, putative 0.0217 0.0147 0.0616
Leishmania major cyclophilin 4, putative 0.0044 0.0021 0.0072
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0074 0.0044 0.0155
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0005 0.0015
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.0687 0.0488 0.0488
Trypanosoma cruzi cyclophilin, putative 0.0044 0.0021 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0217 0.0147 0.0616
Brugia malayi hypothetical protein 0.0115 0.0073 0.0073
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0028 0.001 0.0009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0113 0.0072 0.0254
Brugia malayi Pre-SET motif family protein 0.0207 0.014 0.014
Trypanosoma brucei cyclophilin, putative 0.0044 0.0021 0.0076
Loa Loa (eye worm) hypothetical protein 0.1609 0.1157 0.1157
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0019
Schistosoma mansoni neprilysin 0.0568 0.0402 0.1428
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0055 0.003 0.0029
Brugia malayi hypothetical protein 0.004 0.0019 0.0019
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0019 0.017
Schistosoma mansoni ets-related 0.0166 0.011 0.0391
Echinococcus granulosus calpain 5 0.0019 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.2178 0.157 0.1569
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Echinococcus multilocularis heat shock protein 0.0217 0.0147 0.0521
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0272 0.0187 0.066
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0041 0.0413
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0005 0.0014
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0001 0.0005
Echinococcus multilocularis ribonuclease H1 0.0021 0.0005 0.0018
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0014 0.0014
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0004 0.0009
Schistosoma mansoni Smad4 0.0033 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.1609 0.1157 0.1157
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0074 0.0044 0.0155
Trypanosoma brucei antigen, putative 0.0019 0.0004 0.0013
Mycobacterium ulcerans putative regultory protein 0.0217 0.0147 0.0608
Onchocerca volvulus 0.0044 0.0021 0.0274
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0687 0.0488 0.1734
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0042 0.0418
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0004 0.0013
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.004 0.0019 0.0075
Echinococcus granulosus expressed protein 0.0044 0.0021 0.0075
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0687 0.0488 0.0488
Echinococcus multilocularis endothelin converting enzyme 1 0.2178 0.157 0.5579
Onchocerca volvulus 0.0026 0.0009 0.0111
Entamoeba histolytica heat shock protein 90, putative 0.0217 0.0147 0.1571
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.001 0.0073
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0012 0.0042
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0217 0.0147 0.0608
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0008 0.0028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Chlamydia trachomatis DNA ligase 0.004 0.0019 0.1088
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0019 0.0004 0.0013
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0004 0.0013
Loa Loa (eye worm) calpain family protein 1 0.0064 0.0036 0.0036
Brugia malayi RNase H family protein 0.0021 0.0005 0.0005
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0217 0.0147 0.0616
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0008
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0038 0.0018 0.0062
Brugia malayi MH1 domain containing protein 0.0033 0.0014 0.0014
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.1361 0.0977 0.3469
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0217 0.0147 0.0616
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0019 0.0004 0.0004
Leishmania major DNA polymerase kappa, putative 0.002 0.0005 0.0012
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0217 0.0147 0.0616
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.3272 0.2364 0.8401
Leishmania major cyclophilin 11, putative 0.0044 0.0021 0.0072
Brugia malayi calpain family protein 1 0.0064 0.0036 0.0036
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0073 0.0259
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0004 0.0009
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0019 0.0004 0.0013
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0019 0.0004 0.0013
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0217 0.0147 0.0608
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0108 0.0068 0.0274
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0014 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0008 0.0019
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0012 0.0042
Trypanosoma cruzi polo-like protein kinase, putative 0.0071 0.0042 0.0143
Loa Loa (eye worm) hypothetical protein 0.3892 0.2813 0.2813
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0009 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0005 0.0012
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0217 0.0147 0.0616
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0005 0.0015
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0004 0.0009
Echinococcus granulosus survival motor neuron protein 1 0.0758 0.054 0.1917
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0012 0.0153
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0003 0.0008
Echinococcus multilocularis Zinc finger, PHD finger 0.0028 0.001 0.0034
Schistosoma mansoni lysosomal protective protein precursor (cathepsin A) (carboxypeptidase 0.0068 0.0039 0.0138
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0015 0.0131
Echinococcus granulosus ubiquitin specific protease 41 0.0028 0.001 0.0035
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Giardia lamblia Replication factor C, subunit 1 0.004 0.0019 0.1061
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0003 0.0009
Echinococcus granulosus lamin dm0 0.0024 0.0007 0.0025
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0009 0.0009
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0012 0.0042
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0019 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Brugia malayi hypothetical protein 0.0758 0.054 0.0539
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0028 0.001 0.003
Brugia malayi nuclear receptor RXR 0.0016 0.0002 0.0001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0004 0.0009
Trypanosoma brucei DNA topoisomerase ii 0.0217 0.0147 0.0522
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Onchocerca volvulus 0.0026 0.0009 0.0111
Schistosoma mansoni Smad4 0.0015 0.0001 0.0001
Echinococcus granulosus lysine specific demethylase 5A 0.0047 0.0024 0.0084
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0044 0.0022 0.0077
Mycobacterium ulcerans DNA gyrase subunit B 0.0217 0.0147 0.0608
Brugia malayi serine/threonine-protein kinase plk-2 0.0071 0.0042 0.0041
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0004 0.0013
Trypanosoma brucei heat shock protein, putative 0.0217 0.0147 0.0522
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0004 0.0012
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0071 0.0042 0.0041
Schistosoma mansoni patched 1 0.0087 0.0053 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0012 0.0042
Schistosoma mansoni hypothetical protein 0.008 0.0048 0.017
Trypanosoma brucei heat shock protein 90, putative 0.0217 0.0147 0.0522
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0004 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0012 0.0012
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0028 0.001 0.0035
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0008 0.0049
Echinococcus multilocularis expressed conserved protein 0.019 0.0127 0.0452
Echinococcus multilocularis lysosomal protective protein 0.0687 0.0488 0.1734
Leishmania major DNA topoisomerase ii 0.0217 0.0147 0.0518
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0212 0.0143 0.1531
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0003
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0001 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0012 0.0042
Onchocerca volvulus Ribonuclease H1 homolog 0.0021 0.0005 0.0065
Entamoeba histolytica protein kinase, putative 0.0019 0.0004 0.0005
Schistosoma mansoni lamin 0.0024 0.0007 0.0025
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Loa Loa (eye worm) hypothetical protein 0.0217 0.0147 0.0147
Leishmania major DNA polymerase eta, putative 0.002 0.0005 0.0012
Onchocerca volvulus 0.0026 0.0009 0.0111
Leishmania major developmentally regulated phosphoprotein-like protein 0.3892 0.2813 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0019 0.017
Echinococcus multilocularis calpain 5 0.0019 0.0004 0.0012
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0217 0.0147 0.0147
Brugia malayi hypothetical protein 0.0016 0.0002 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0042 0.0418
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.0019 0.017
Brugia malayi MH2 domain containing protein 0.0033 0.0014 0.0014
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0004 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0027 0.0093
Schistosoma mansoni hypothetical protein 0.0084 0.005 0.0178
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.0136 0.0483
Schistosoma mansoni hypothetical protein 0.0084 0.005 0.0178
Echinococcus multilocularis geminin 0.017 0.0113 0.0402
Plasmodium vivax DNA gyrase subunit B, putative 0.0217 0.0147 0.0616
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.004 0.0019 0.0047
Trypanosoma brucei kinesin, putative 0.0019 0.0004 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0113 0.0072 0.0254
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0244 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0084 0.005 0.0178
Trypanosoma brucei ribonuclease H1 0.0021 0.0005 0.0019
Trypanosoma brucei unspecified product 0.002 0.0005 0.0016
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0217 0.0147 0.9793
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0005 0.0012
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0074 0.0044 0.0044
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0019 0.0004 0.0006
Schistosoma mansoni neprilysin-2 (M13 family) 0.1099 0.0787 0.2796
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0005 0.0012
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.0019 0.0019
Echinococcus granulosus smad 0.0033 0.0014 0.0049
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0004 0.0009
Onchocerca volvulus 0.0024 0.0007 0.0092
Onchocerca volvulus 0.1079 0.0773 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0217 0.0147 0.1571
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0001 0.0001
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0028 0.001 0.0454
Brugia malayi latrophilin 2 splice variant baaae 0.0244 0.0167 0.0167
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0272 0.0187 0.066
Plasmodium vivax endoplasmin, putative 0.0217 0.0147 0.0616
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0003 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0003
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Loa Loa (eye worm) calpain family protein 1 0.0045 0.0023 0.0022
Plasmodium vivax SET domain protein, putative 0.0031 0.0012 0.0045
Trichomonas vaginalis DNA topoisomerase II, putative 0.0217 0.0147 0.1571
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0012 0.0012
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0687 0.0488 0.6318
Loa Loa (eye worm) hypothetical protein 0.1647 0.1185 0.1185
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0129 0.0083 0.0291
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0217 0.0147 0.0616
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.001
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0217 0.0147 0.0608
Loa Loa (eye worm) calpain 5 0.0019 0.0004 0.0003
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0217 0.0147 0.0616
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0042 0.0418
Echinococcus multilocularis protein dispatched 1 0.0099 0.0062 0.0218
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0004 0.0009
Trichomonas vaginalis heat shock protein, putative 0.0217 0.0147 0.1571
Brugia malayi MH1 domain containing protein 0.0018 0.0003 0.0003
Brugia malayi Blistered cuticle protein 3 0.0026 0.0009 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0005 0.0004
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0008 0.0019
Loa Loa (eye worm) calpain 0.0019 0.0004 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Brugia malayi nuclear hormone receptor 0.0031 0.0012 0.0012
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0217 0.0147 0.1571
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0137 0.0089 0.0316
Loa Loa (eye worm) hypothetical protein 0.0047 0.0024 0.0023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0012 0.0042
Brugia malayi Ets-domain containing protein 0.0055 0.003 0.0029
Onchocerca volvulus Peroxidase homolog 0.0026 0.0009 0.0111
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0129 0.0083 0.0295
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.3272 0.2364 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0003
Trypanosoma cruzi ribonuclease H1, putative 0.0021 0.0005 0.0015
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0217 0.0147 0.0518
Leishmania major kinesin, putative 0.0019 0.0004 0.0009
Trichomonas vaginalis endoplasmin, putative 0.0217 0.0147 0.1571
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0023 0.0007 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0003 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0024 0.0084
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0212 0.0143 0.1531
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0014 0.0049
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0217 0.0147 0.0616
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0012 0.0042
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.3892 0.2813 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0008 0.0019
Echinococcus multilocularis musashi 0.0024 0.0007 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0012 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Schistosoma mansoni DNA ligase IV 0.004 0.0019 0.0066
Loa Loa (eye worm) hypothetical protein 0.0358 0.0249 0.0249
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0019 0.0063
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1278 0.0917 1
Schistosoma mansoni hypothetical protein 0.0074 0.0044 0.0155
Schistosoma mansoni endoplasmin 0.0217 0.0147 0.0521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0027 0.0093
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0005 0.0015
Onchocerca volvulus 0.0045 0.0023 0.0288
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0002 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0008 0.0049
Plasmodium falciparum endoplasmin, putative 0.0217 0.0147 0.0616
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0687 0.0488 0.1731
Loa Loa (eye worm) hypothetical protein 0.2178 0.157 0.1569
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0071 0.0042 0.0147
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0004 0.0009
Plasmodium falciparum DNA topoisomerase 2 0.0217 0.0147 0.0616
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.2178 0.157 0.6639
Loa Loa (eye worm) hypothetical protein 0.1609 0.1157 0.1157
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0042 0.0418
Schistosoma mansoni topbp1 0.004 0.0019 0.0066
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.0019 0.0063
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0003 0.0011
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0004 0.0012
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0217 0.0147 0.0616
Trypanosoma cruzi heat shock protein 90, putative 0.0217 0.0147 0.0518
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0012 0.0012
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0009 0.0009
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0217 0.0147 0.0616
Entamoeba histolytica heat shock protein 90, putative 0.0217 0.0147 0.1571
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0071 0.0041 0.0413
Echinococcus granulosus intermediate filament protein 0.0024 0.0007 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.0489 0.1738
Brugia malayi steroid hormone receptor 0.0031 0.0012 0.0012
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0212 0.0143 0.1531
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0007 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0038 0.0018 0.0058
Entamoeba histolytica hypothetical protein 0.0168 0.0112 0.1188
Schistosoma mansoni phosphoglucomutase 0.0021 0.0005 0.0018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0048 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0012 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0129 0.0083 0.0291
Schistosoma mansoni DNA topoisomerase II 0.0217 0.0147 0.0521
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0012 0.0042
Schistosoma mansoni hypothetical protein 0.0677 0.0481 0.1708
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0071 0.0042 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0004 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0042 0.0418
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0012 0.0012
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0028 0.001 0.0034
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0001 0.0003
Loa Loa (eye worm) phosphatidylinositol 3 0.0065 0.0037 0.0036
Entamoeba histolytica hypothetical protein 0.0115 0.0073 0.0762
Plasmodium vivax calpain, putative 0.0019 0.0004 0.001
Trichomonas vaginalis receptor histidine kinase, putative 0.0217 0.0147 0.1571
Echinococcus multilocularis calpain 0.0019 0.0004 0.0012
Brugia malayi MH1 domain containing protein 0.0033 0.0014 0.0014
Toxoplasma gondii peptidase family M13 protein 0.2178 0.157 0.6639
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0272 0.0187 0.0664
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.053 0.0375 0.1331
Echinococcus granulosus expressed conserved protein 0.019 0.0127 0.0452
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0028 0.001 0.007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0027 0.0026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0358 0.0249 0.0249
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0005
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0217 0.0147 0.1898
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.3272 0.2364 0.2363
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0113 0.0072 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0012 0.0012
Toxoplasma gondii heat shock protein HSP90 0.0217 0.0147 0.0616
Trypanosoma brucei heat shock protein, putative 0.0217 0.0147 0.0522
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.0044
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.0136 0.0483
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0005 0.0018
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0217 0.0147 0.0616
Schistosoma mansoni smad 0.0033 0.0014 0.0049
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0168 0.0112 0.1188
Echinococcus granulosus geminin 0.017 0.0113 0.0402
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0021 0.0005 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0358 0.0249 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0042 0.0418
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0005 0.0005
Echinococcus granulosus GA binding protein alpha chain 0.0055 0.003 0.0104
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0002 0.0004
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0053 0.0186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0027 0.0093
Schistosoma mansoni survival motor neuron protein 0.0155 0.0102 0.0361
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0028 0.001 0.0035
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0145 0.0095 0.1005
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1278 0.0917 0.3258
Brugia malayi topoisomerase 0.004 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0012 0.0012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0003 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0113 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Echinococcus granulosus dnaJ subfamily B 0.0677 0.0481 0.1708
Echinococcus granulosus Smad4 0.0033 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0012 0.0042
Schistosoma mansoni hypothetical protein 0.0074 0.0044 0.0155
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0005 0.0004
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0005 0.0016
Trypanosoma brucei heat shock protein 90, putative 0.0217 0.0147 0.0522
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0011 0.0036
Mycobacterium tuberculosis Possible two component sensor kinase 0.0217 0.0147 0.0616
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0217 0.0147 0.0608
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0024 0.0079
Trypanosoma cruzi heat shock protein 85, putative 0.0217 0.0147 0.0518
Echinococcus multilocularis ubiquitin specific protease 41 0.0028 0.001 0.0035
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0217 0.0147 0.0608
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0019 0.017
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0217 0.0147 0.0608
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0012 0.0042
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0071 0.0041 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0012 0.0012
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.1361 0.0977 0.413
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0005 0.0018
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0137 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0298 0.0206 0.0206
Trypanosoma brucei polo-like protein kinase 0.0071 0.0042 0.0148
Loa Loa (eye worm) TOPoisomerase family member 0.0217 0.0147 0.0147
Entamoeba histolytica hypothetical protein 0.0115 0.0073 0.0762
Leishmania major cyclophilin a 0.0044 0.0021 0.0072
Loa Loa (eye worm) hypothetical protein 0.0064 0.0036 0.0036
Schistosoma mansoni endoplasmin 0.0217 0.0147 0.0521
Toxoplasma gondii exonuclease III APE 0.0019 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.1079 0.0773 0.0772
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0001 0.0003
Echinococcus granulosus GPCR family 2 0.0113 0.0072 0.0254
Schistosoma mansoni kinase 0.0036 0.0016 0.0056
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0009 0.0111
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0003 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Onchocerca volvulus 0.0025 0.0008 0.0098
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0687 0.0488 0.1731
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0019 0.0004 0.0013
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0145 0.0095 0.1005
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0002 0.0001
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-3, Bmcyp-3 0.0044 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0044 0.0021 0.0085
Trypanosoma brucei Heat shock protein 83, putative 0.0217 0.0147 0.0522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.1278 0.0917 1
Brugia malayi Peptidase family M13 containing protein 0.2178 0.157 0.1569
Loa Loa (eye worm) zinc metallopeptidase 4 0.053 0.0375 0.0374
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0155 0.0102 0.0102
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0014 0.0049
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.0019 0.0019
Schistosoma mansoni cyclophilin 0.0044 0.0021 0.0075
Trypanosoma cruzi DNA topoisomerase II, putative 0.0217 0.0147 0.0518
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.1099 0.0787 0.2796
Schistosoma mansoni smad 0.0015 0.0001 0.0001
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0019 0.0004 0.0004
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.053 0.0375 0.1331
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0687 0.0488 0.1731
Brugia malayi Fli-1 protein 0.0166 0.011 0.011
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0009 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0019 0.017
Echinococcus granulosus lysosomal protective protein 0.0687 0.0488 0.1734
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0217 0.0147 0.0616
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0217 0.0147 0.0518
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2477 0.1787 0.6351
Echinococcus multilocularis nibrin 0.004 0.0019 0.0066
Loa Loa (eye worm) hypothetical protein 0.2178 0.157 0.1569
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0044 0.0021 0.0076
Loa Loa (eye worm) cyclophilin Ovcyp-2 0.0044 0.0021 0.0021
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0028 0.001 0.003
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0028 0.001 0.007
Loa Loa (eye worm) hypothetical protein 0.0075 0.0044 0.0044
Echinococcus multilocularis survival motor neuron protein 1 0.0758 0.054 0.1917
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1278 0.0917 1
Brugia malayi hypothetical protein 0.0016 0.0002 0.0001
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0071 0.0041 0.0145
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0008 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Schistosoma mansoni hypothetical protein 0.0244 0.0167 0.0593
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0008 0.0024
Plasmodium falciparum DNA gyrase subunit B 0.0217 0.0147 0.0616
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0028 0.001 0.0073
Echinococcus granulosus replication factor c subunit 1 0.004 0.0019 0.0066
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0004 0.0009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Echinococcus granulosus muscleblind protein 0.0298 0.0206 0.0731
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0019 0.0004 0.0013
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Treponema pallidum fructose-bisphosphate aldolase 0.0221 0.015 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0008 0.0024
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.053 0.0375 0.1331
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0005 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0015 0.0131
Loa Loa (eye worm) heat shock protein 90 0.0217 0.0147 0.0147
Trichomonas vaginalis heat shock protein, putative 0.0217 0.0147 0.1571
Chlamydia trachomatis DNA gyrase subunit B 0.0217 0.0147 1
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0019 0.0004 0.0006
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0687 0.0488 0.1735
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.0019 0.0066
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0687 0.0488 0.1735
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0217 0.0147 0.1898
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.3272 0.2364 0.84
Loa Loa (eye worm) hypothetical protein 0.0228 0.0155 0.0155
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0009 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0012 0.0012
Toxoplasma gondii cyclophilin precursor 0.0044 0.0021 0.0085
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0217 0.0147 0.0616
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0012 0.0042
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-2, Bmcyp-2 0.0044 0.0021 0.0021
Echinococcus multilocularis dna polymerase eta 0.002 0.0005 0.0015
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Echinococcus granulosus calpain A 0.0068 0.0039 0.0137
Schistosoma mansoni smad1 5 8 and 0.0033 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0019 0.0004 0.0004
Schistosoma mansoni apoptosis regulator bax 0.0074 0.0044 0.0155
Brugia malayi jmjC domain containing protein 0.0047 0.0024 0.0024
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0071 0.0041 0.0413
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0073 0.0259
Echinococcus granulosus calpain 0.0019 0.0004 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0027 0.0093
Schistosoma mansoni phosphoglucomutase 0.0021 0.0005 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0012 0.0042
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0217 0.0147 0.0518
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0044 0.0022 0.0077
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.0004 0.0006
Loa Loa (eye worm) peptidase family M13 containing protein 0.1609 0.1157 0.1157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0012 0.0042
Plasmodium vivax heat shock protein 86, putative 0.0217 0.0147 0.0616
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1278 0.0917 1
Trypanosoma brucei heat shock protein, putative 0.0217 0.0147 0.0522
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0027 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0012 0.0012
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.0136 0.0136
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0005 0.0012
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0186 0.0125 0.0125
Giardia lamblia Pms1-like protein 0.0217 0.0147 0.9793
Trypanosoma brucei heat shock protein, putative 0.0217 0.0147 0.0522
Brugia malayi intermediate filament protein 0.0024 0.0007 0.0007
Schistosoma mansoni jumonji domain containing protein 0.0044 0.0022 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0042 0.0147
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0009 0.0009
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.0019 0.017
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0004 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0012 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0008 0.0028
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0012 0.0012
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0212 0.0143 0.1531
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0217 0.0147 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0003 0.0008
Brugia malayi ecdysteroid receptor 0.0031 0.0012 0.0012
Echinococcus granulosus dna polymerase eta 0.002 0.0005 0.0015
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0041 0.0413
Toxoplasma gondii hypothetical protein 0.0044 0.0022 0.0086
Onchocerca volvulus 0.0024 0.0007 0.0092
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0008
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.0019 0.0075
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.3272 0.2364 0.84
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0068 0.0039 0.0137
Schistosoma mansoni smad1 5 8 and 0.0033 0.0014 0.0049
Schistosoma mansoni hypothetical protein 0.0113 0.0072 0.0254
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0003 0.0011
Schistosoma mansoni dihydroorotate dehydrogenase 0.3272 0.2364 0.8401
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0003
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0217 0.0147 0.9793
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0038 0.0018 0.0058
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0012 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0143 0.0094 0.0391
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1278 0.0917 0.3258
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0004 0.0013
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0028 0.001 0.0034
Schistosoma mansoni hypothetical protein 0.0084 0.005 0.0178
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1278 0.0917 0.3255
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0012 0.0042
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0217 0.0147 0.059
Loa Loa (eye worm) hypothetical protein 0.0045 0.0023 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0053 0.0539
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0115 0.0073 0.0762
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0004 0.0009
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0619 0.0439 0.1559
Trypanosoma cruzi heat shock protein 85, putative 0.0217 0.0147 0.0518
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0014 0.0049
Trypanosoma brucei heat shock protein, putative 0.0217 0.0147 0.0522
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0217 0.0147 0.0616
Mycobacterium leprae probable zinc metalloprotease 0.2178 0.157 0.663
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0358 0.0249 0.0249
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0217 0.0147 0.0608
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0028 0.001 0.0035
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0028 0.001 0.001
Echinococcus multilocularis GA binding protein alpha chain 0.0055 0.003 0.0104
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0003 0.0006
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0019 0.0004 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0024 0.0084
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0028 0.001 0.0009
Trichomonas vaginalis ribonuclease H1, putative 0.0021 0.0005 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0102 0.0064 0.0225
Onchocerca volvulus 0.0031 0.0012 0.0153
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Echinococcus multilocularis replication factor c subunit 1 0.004 0.0019 0.0066
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0217 0.0147 0.0147
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0028 0.001 0.007
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0217 0.0147 0.0522
Schistosoma mansoni Smad4 0.0015 0.0001 0.0001
Entamoeba histolytica serine/threonine protein kinase, putative 0.0071 0.0042 0.0418
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0001 0.0003
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.1278 0.0917 1
Schistosoma mansoni hypothetical protein 0.0568 0.0402 0.1428
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.0019 0.0066
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0028 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0102 0.0064 0.4127
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0012 0.0042
Schistosoma mansoni cpg binding protein 0.005 0.0026 0.0092
Echinococcus multilocularis peroxidasin 0.0026 0.0009 0.003
Loa Loa (eye worm) hypothetical protein 0.1647 0.1185 0.1185
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0004 0.0012
Trypanosoma brucei RNA helicase, putative 0.008 0.0048 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0115 0.0073 0.0259
Trypanosoma brucei heat shock protein, putative 0.0217 0.0147 0.0522
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0161 0.1724
Brugia malayi CHE-14 protein 0.0087 0.0053 0.0052
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0217 0.0147 0.0616
Entamoeba histolytica hypothetical protein 0.0115 0.0073 0.0762
Schistosoma mansoni DNA polymerase eta 0.002 0.0005 0.0015
Giardia lamblia Heat shock protein HSP 90-alpha 0.0217 0.0147 0.9793
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0028 0.001 0.0034
Echinococcus granulosus ribonuclease H1 0.0021 0.0005 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0012 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0003 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0005 0.0016
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0212 0.0143 0.0505
Onchocerca volvulus Peroxidase homolog 0.0026 0.0009 0.0111
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0073 0.0259
Mycobacterium leprae Probable two-component sensor kinase 0.0217 0.0147 0.059
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0012 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0012 0.0012
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0028 0.001 0.0031
Brugia malayi hypothetical protein 0.0228 0.0155 0.0155
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0001 0.0001
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0071 0.0042 0.0147
Brugia malayi peptidase family M13 containing protein 0.053 0.0375 0.0374
Loa Loa (eye worm) hypothetical protein 0.1647 0.1185 0.1185
Echinococcus multilocularis cpg binding protein 0.005 0.0026 0.0092
Giardia lamblia Fructose-bisphosphate aldolase 0.0221 0.015 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0298 0.0206 0.0206
Entamoeba histolytica DNA topoisomerase II, putative 0.0217 0.0147 0.1571
Loa Loa (eye worm) hypothetical protein 0.0113 0.0072 0.0072
Mycobacterium ulcerans two component regulator - sensor kinase 0.0217 0.0147 0.0608
Onchocerca volvulus 0.0228 0.0155 0.2008
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.0019 0.0075
Echinococcus multilocularis dna polymerase kappa 0.002 0.0005 0.0015
Schistosoma mansoni pyruvate dehydrogenase 0.3676 0.2656 0.9442
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.0139 0.0491
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.3272 0.2364 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0003 0.0009
Echinococcus multilocularis Smad4 0.0033 0.0014 0.0049
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0094 0.0058 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0016
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.3272 0.2364 0.2363
Loa Loa (eye worm) histone methyltransferase 0.0016 0.0001 0.0001
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.3272 0.2364 0.84
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0008 0.0019
Plasmodium falciparum heat shock protein 90 0.0217 0.0147 0.0616
Brugia malayi hypothetical protein 0.004 0.0019 0.0019
Trypanosoma cruzi kinesin, putative 0.0019 0.0004 0.0009
Echinococcus multilocularis lamin 0.0024 0.0007 0.0025
Echinococcus multilocularis protein patched 0.0087 0.0053 0.0186
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0052
Brugia malayi jmjC domain containing protein 0.0044 0.0022 0.0022
Echinococcus granulosus calpain A 0.0019 0.0004 0.0012
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0019 0.0004 0.0013
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0005 0.0012
Plasmodium falciparum dihydroorotate dehydrogenase 0.3272 0.2364 1
Plasmodium vivax unspecified product 0.0044 0.0021 0.0085
Loa Loa (eye worm) hypothetical protein 0.0758 0.054 0.0539
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.1361 0.0977 0.3469
Brugia malayi heat shock protein 90 0.0217 0.0147 0.0147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Echinococcus multilocularis smad 0.0033 0.0014 0.0049
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0004 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0012 0.0042
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.3272 0.2364 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0005 0.0004
Giardia lamblia Ribonuclease H 0.0021 0.0005 0.0132
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0113 0.0072 0.0254
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0028 0.001 0.007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0012 0.0042
Plasmodium vivax DNA topoisomerase II, putative 0.0217 0.0147 0.0616
Schistosoma mansoni intermediate filament proteins 0.0024 0.0007 0.0025
Onchocerca volvulus 0.004 0.0019 0.0241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0221 0.015 0.1604
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0001 0.0001
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.1099 0.0787 0.2796
Echinococcus granulosus endothelin converting enzyme 1 0.2178 0.157 0.5579
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0038 0.0018 0.0058
Loa Loa (eye worm) hypothetical protein 0.1647 0.1185 0.1185
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0008 0.0019
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0019
Echinococcus granulosus cpg binding protein 0.005 0.0026 0.0092
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0028 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0064 0.0036 0.0036
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0028 0.001 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0012 0.0012
Onchocerca volvulus 0.0044 0.0021 0.0274
Schistosoma mansoni hypothetical protein 0.0568 0.0402 0.1428
Mycobacterium ulcerans zinc metalloprotease 0.2178 0.157 0.6636
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0005 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0002 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0003 0.0006
Echinococcus granulosus nibrin 0.004 0.0019 0.0066
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0039 0.0137
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0012 0.0153
Toxoplasma gondii histone lysine methyltransferase SET1 0.0091 0.0056 0.0231
Toxoplasma gondii cyclophilin 1, putative 0.0044 0.0021 0.0085
Schistosoma mansoni endothelin-converting enzyme-related 0.053 0.0375 0.1331
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0137 0.0089 0.0089
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0019 0.017
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0217 0.0147 0.0608
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0012 0.0012
Echinococcus multilocularis expressed protein 0.0044 0.0021 0.0075
Leishmania major heat shock protein 83-1 0.0217 0.0147 0.0518
Echinococcus granulosus heat shock protein 90 0.0217 0.0147 0.0521
Schistosoma mansoni hypothetical protein 0.0568 0.0402 0.1428
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0687 0.0488 0.1731
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0019 0.0067
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.053 0.0375 0.1331
Trypanosoma cruzi heat shock protein 90, putative 0.0217 0.0147 0.0518
Loa Loa (eye worm) angiotensin-converting enzyme family protein 1.3798 1 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0008 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.049 0.0346 0.0345
Echinococcus granulosus peroxidasin 0.0026 0.0009 0.003
Brugia malayi RNase H family protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.049 0.0346 0.0345
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0071 0.0041 0.0413
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0012 0.0042
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.3272 0.2364 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.017 0.0113 0.0402
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0398 0.0278 0.0989
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0028 0.001 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0019 0.017
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0137 0.0089 0.0316
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0012 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0042 0.0418
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0049 0.0026 0.1521
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.1099 0.0787 0.2796
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0012 0.0153
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0044 0.0021 0.0076
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0002 0.0001
Echinococcus multilocularis dnaJ subfamily B 0.0677 0.0481 0.1708
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0205 0.0139 0.1482
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0053 0.0186
Plasmodium vivax cyclophilin, putative 0.0044 0.0021 0.0085
Schistosoma mansoni lamin 0.0024 0.0007 0.0025
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0012 0.0042
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.053 0.0375 0.1331
Loa Loa (eye worm) hypothetical protein 0.1609 0.1157 0.1157
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.014 0.014
Leishmania major mitochondrial DNA topoisomerase II 0.0217 0.0147 0.0518
Echinococcus multilocularis lamin dm0 0.0024 0.0007 0.0025
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0217 0.0147 0.0521
Brugia malayi MH1 domain containing protein 0.0018 0.0003 0.0003
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0065 0.0037 0.0126
Brugia malayi Ets-domain containing protein 0.0055 0.003 0.0029
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0217 0.0147 0.0608
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0028 0.001 0.0036
Trypanosoma brucei developmentally regulated phosphoprotein 0.3892 0.2813 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1278 0.0917 0.3258
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0028 0.001 0.0035
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.004 0.0019 0.017
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0028 0.001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Brugia malayi calpain family protein 1 0.0064 0.0036 0.0036
Brugia malayi MH2 domain containing protein 0.049 0.0346 0.0345
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0004 0.0012
Mycobacterium ulcerans two component sensor kinase MprB 0.0217 0.0147 0.0608
Schistosoma mansoni hypothetical protein 0.0155 0.0102 0.0361
Brugia malayi Probable DNA topoisomerase II 0.0217 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0202 0.0136 0.0136
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase A, ppia, putative 0.0044 0.0021 0.0198
Schistosoma mansoni cpg binding protein 0.0048 0.0024 0.0085
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0217 0.0147 0.0522
Schistosoma mansoni pyruvate dehydrogenase 0.3676 0.2656 0.9442
Trypanosoma brucei unspecified product 0.0023 0.0007 0.0024
Brugia malayi DKFZp564C0469 protein 0.004 0.0019 0.0019
Schistosoma mansoni topbp1 0.004 0.0019 0.0066
Toxoplasma gondii ribonuclease HI protein 0.0021 0.0005 0.0017
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0012 0.0012

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 18.8 uM Concentration required to stimulate binding of [35S]-GTP-gammaS, with G alpha i3 ChEMBL. 16190775
EC50 (functional) = 25.5 uM Concentration required to stimulate binding of [35S]-GTP-gammaS, with G alpha o1 ChEMBL. 16190775
EC50 (functional) = 36.4 uM Concentration required to stimulate binding of [35S]-GTP-gammaS, with G alpha i1 ChEMBL. 16190775
Stimulation (functional) = 1484 % Percent stimulation of [35S]-GTP-gammaS, binding to G alpha i1 at 5E-5 M of basal for 30 minutes ChEMBL. 16190775
Stimulation (functional) = 2005 % Percent stimulation of [35S]-GTP-gammaS, binding to G alpha i3 at 5E-5 M of basal for 30 minutes ChEMBL. 16190775
Stimulation (functional) = 2349 % Percent stimulation of [35S]-GTP-gammaS, binding to G alpha o1 at 5E-5 M of basal for 30 minutes ChEMBL. 16190775

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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