Detailed information for compound 18936

Basic information

Technical information
  • TDR Targets ID: 18936
  • Name: 1-N-[(4-carbamimidoylphenyl)methyl]-2-N-ethyl -2-N-(2-methoxyphenyl)cyclopent-2-ene-1,2-dic arboxamide
  • MW: 420.504 | Formula: C24H28N4O3
  • H donors: 2 H acceptors: 2 LogP: 2.26 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccccc1OC)C(=O)C1=CCCC1C(=O)NCc1ccc(cc1)C(=N)N
  • InChi: 1S/C24H28N4O3/c1-3-28(20-9-4-5-10-21(20)31-2)24(30)19-8-6-7-18(19)23(29)27-15-16-11-13-17(14-12-16)22(25)26/h4-5,8-14,18H,3,6-7,15H2,1-2H3,(H3,25,26)(H,27,29)
  • InChiKey: VETCZJKUAKLERV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N1-[(4-carbamimidoylphenyl)methyl]-N2-ethyl-N2-(2-methoxyphenyl)cyclopent-2-ene-1,2-dicarboxamide
  • N-(4-amidinobenzyl)-N'-ethyl-N'-(2-methoxyphenyl)cyclopent-2-ene-1,2-dicarboxamide
  • N-[(4-carbamimidoylphenyl)methyl]-N'-ethyl-N'-(2-methoxyphenyl)cyclopent-2-ene-1,2-dicarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0444 0.0634
Mycobacterium ulcerans hypothetical protein 0.0075 0.099 0.0783
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0101 0.023
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0101 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Entamoeba histolytica hypothetical protein 0.0035 0.0217 0.1367
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0266 0.0301
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.022 0.0215
Loa Loa (eye worm) hypothetical protein 0.0079 0.1072 0.182
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Onchocerca volvulus 0.0075 0.099 0.3064
Schistosoma mansoni immunophilin 0.0053 0.0561 0.0852
Leishmania major hypothetical protein, conserved 0.0035 0.0225 0.142
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0494 0.1126
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0552 0.0836
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1585 0.2766
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2721 0.6209
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.022 0.1387
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.022 0.1387
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.022 0.0502
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0331 0.2086
Loa Loa (eye worm) hypothetical protein 0.0096 0.1383 0.24
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2721 0.6209
Trypanosoma brucei cysteine peptidase C (CPC) 0.0098 0.1422 0.8906
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.4167 0.7592
Brugia malayi Cathepsin L-like precursor 0.0052 0.0552 0.1094
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0273 0.1722
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0266 0.5
Echinococcus granulosus snurportin 1 0.0309 0.5456 1
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0552 0.085
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0552 0.0836
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0561 0.3119
Brugia malayi Trypsin family protein 0.0075 0.099 0.199
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0444 0.0634
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0266 0.1675
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0143 0.0071
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0444 0.0876
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Loa Loa (eye worm) hypothetical protein 0.0069 0.0875 0.1452
Loa Loa (eye worm) hypothetical protein 0.0035 0.0225 0.024
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0235 0.0244
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0494 0.0727
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0552 0.126
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0101 0.023
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0053 0.0561 0.3098
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0105 0.0028
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0053 0.0561 0.3538
Plasmodium vivax vivapain-1 0.0031 0.0143 0.0906
Trypanosoma cruzi kinesin, putative 0.0028 0.0096 0.0197
Echinococcus multilocularis transmembrane protease serine 3 0.0075 0.099 0.1655
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0143 0.031
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.4383 0.7998
Loa Loa (eye worm) hypothetical protein 0.0047 0.0444 0.0648
Brugia malayi cathepsin L-like precursor 0.0038 0.0273 0.0523
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0235 0.0244
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0217 0.0209
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0552 0.1094
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0266 0.1675
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0143 0.0899
Echinococcus multilocularis calpain 0.0041 0.0331 0.0422
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0098 0.1422 0.2462
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0266 0.0508
Leishmania major cathepsin L-like protease 0.0052 0.0552 0.3483
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0143 0.0899
Onchocerca volvulus 0.0047 0.0444 0.0876
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.004 0.0312 0.0602
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0101 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0101 0.023
Schistosoma mansoni survival motor neuron protein 0.0049 0.0493 0.0726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.022 0.0448
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.022 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0101 0.023
Schistosoma mansoni Mername-AA248 (C02 family) 0.0041 0.0331 0.0422
Plasmodium falciparum importin beta, putative 0.0029 0.0105 0.0081
Plasmodium vivax calpain, putative 0.0041 0.0331 0.4996
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0266 0.1136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0552 0.126
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0402
Loa Loa (eye worm) MBCTL1 0.0053 0.0567 0.0879
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0552 0.126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0552 0.0836
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0235 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Plasmodium vivax vivapain-2 0.0052 0.0552 0.9813
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.004 0.0312 0.0402
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2721 0.6209
Leishmania major cathepsin L-like protease 0.0052 0.0552 0.3483
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Onchocerca volvulus 0.0075 0.099 0.3064
Brugia malayi Cytochrome P450 family protein 0.0048 0.0464 0.0914
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0143 0.0291
Loa Loa (eye worm) hypothetical protein 0.0075 0.099 0.1667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0269 0.0323
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0493 0.0973
Brugia malayi Cathepsin L-like precursor 0.0038 0.0273 0.0523
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0444 0.0634
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.022 0.0502
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.3212 0.5807
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0266 0.0041
Brugia malayi Importin beta-1 subunit 0.0029 0.0105 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0225 0.024
Brugia malayi beta-lactamase 0.0035 0.0225 0.0425
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Loa Loa (eye worm) calpain family protein 1 0.0108 0.1617 0.2837
Schistosoma mansoni calpain-7 (C02 family) 0.0044 0.0386 0.0526
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0015
Echinococcus granulosus cysteine protease 0.0031 0.0143 0.0071
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0402
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0331 0.0674
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0494 0.1126
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0075 0.099 0.1655
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0331 0.1573
Loa Loa (eye worm) hypothetical protein 0.0035 0.0225 0.024
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0331 0.0674
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0567 0.0865
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.4383 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0494 0.1007
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0444 0.0634
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.2721 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1585 0.2778
Echinococcus multilocularis cathepsin b 0.028 0.4903 0.8968
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0266 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0235 0.0244
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.099 0.1655
Onchocerca volvulus 0.0052 0.0552 0.131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.099 0.1655
Trypanosoma brucei protein kinase, putative 0.0049 0.0494 0.2668
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0235 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0235 0.0537
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0038 0.0273 0.0556
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0552 0.3483
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.0561 0.0852
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0331 0.1573
Echinococcus multilocularis fibrillin 1 0.004 0.0312 0.0387
Entamoeba histolytica hypothetical protein 0.0035 0.0217 0.1367
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0561 0.0852
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.022 0.0502
Echinococcus granulosus glycoprotein Antigen 5 0.0075 0.099 0.1655
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0143 0.0906
Brugia malayi Ets-domain containing protein 0.007 0.089 0.1786
Onchocerca volvulus 0.0075 0.099 0.3064
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0494 0.3114
Entamoeba histolytica hypothetical protein 0.0035 0.0217 0.1367
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0464 0.0686
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.4167 0.7592
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0552 0.0836
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.4383 1
Echinococcus granulosus enteropeptidase 0.0075 0.099 0.1655
Entamoeba histolytica protein kinase, putative 0.0029 0.0105 0.0662
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0225 0.0514
Echinococcus multilocularis enteropeptidase 0.0075 0.099 0.1655
Leishmania major kinesin, putative 0.0028 0.0096 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Loa Loa (eye worm) hypothetical protein 0.0075 0.099 0.1667
Brugia malayi Calcium binding EGF domain containing protein 0.004 0.0312 0.0602
Schistosoma mansoni hypothetical protein 0.0035 0.0217 0.0209
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0075 0.099 0.1655
Onchocerca volvulus 0.0052 0.0552 0.131
Brugia malayi MAP kinase sur-1 0.0049 0.0494 0.0974
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.022 0.0502
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0101 0.023
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0552 0.3483
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.5456 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0494 0.1007
Trypanosoma cruzi kinesin, putative 0.0028 0.0096 0.0197
Onchocerca volvulus 0.0052 0.0552 0.131
Mycobacterium ulcerans short chain dehydrogenase 0.0546 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0273 0.0329
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.089 0.1468
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0143 0.031
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0552 0.0836
Toxoplasma gondii calcium binding egf domain-containing protein 0.004 0.0312 0.1597
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0561 0.0852
Echinococcus multilocularis glycoprotein Antigen 5 0.0075 0.099 0.1655
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.099 0.1655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Echinococcus multilocularis calpain 7 (C02 family) 0.0041 0.0331 0.0422
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.022 0.0502
Onchocerca volvulus 0.0091 0.1294 0.428
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0266 0.1246
Brugia malayi calpain 5 0.0028 0.0096 0.0161
Trichomonas vaginalis esterase, putative 0.0035 0.0225 0.0514
Schistosoma mansoni ets-related 0.0212 0.3616 0.6562
Loa Loa (eye worm) hypothetical protein 0.028 0.4903 0.8969
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1585 1
Brugia malayi Trypsin family protein 0.0075 0.099 0.199
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Onchocerca volvulus 0.0052 0.0552 0.131
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0552 0.131
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0552 0.131
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0567 0.0865
Schistosoma mansoni hypothetical protein 0.0171 0.2815 0.5065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0552 0.126
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0098 0.1422 0.8972
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1585 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2721 0.6209
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0113 0.171 0.3001
Giardia lamblia Cathepsin B precursor 0.0098 0.1422 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0331 0.0674
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0143 0.0291
Loa Loa (eye worm) hypothetical protein 0.0036 0.0235 0.0259
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0444 0.0634
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0108 0.1617 0.2826
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0225 0.0514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0143 0.0291
Loa Loa (eye worm) hypothetical protein 0.0045 0.0422 0.0607
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0567 0.1125
Plasmodium vivax unspecified product 0.0031 0.0143 0.0906
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0552 0.1126
Schistosoma mansoni hypothetical protein 0.0291 0.512 0.9373
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0552 0.1126
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0422 0.0593
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0494 0.0727
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1585 0.3616
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0331 0.0674
Schistosoma mansoni ap endonuclease 0.0037 0.0266 0.0301
Plasmodium vivax vivapain-3 0.0031 0.0143 0.0906
Onchocerca volvulus 0.0049 0.0493 0.1073
Brugia malayi hypothetical protein 0.0241 0.4167 0.8493
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0075 0.099 0.1655
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Onchocerca volvulus Arrow homolog 0.004 0.0312 0.0348
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.2564 0.4595
Trypanosoma brucei antigen, putative 0.0041 0.0331 0.1573
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0266 0.1109
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0402
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0552 0.3483
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0217 0.0209
Onchocerca volvulus 0.0052 0.0552 0.131
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0331 0.1573
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0552 0.131
Echinococcus multilocularis calpain A 0.0113 0.171 0.3001
Loa Loa (eye worm) cysteine protease 0.0052 0.0552 0.085
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0668 0.1054
Schistosoma mansoni gabp alpha 0.007 0.089 0.1468
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0494 0.2972
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0567 0.0865
Brugia malayi mbt repeat family protein 0.0047 0.0444 0.0873
Loa Loa (eye worm) fibroinase 0.0052 0.0552 0.085
Loa Loa (eye worm) hypothetical protein 0.0075 0.099 0.1667
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0494 0.2668
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0552 0.9813
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0105 0.0055
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.022 0.0502
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.004 0.0312 0.0402
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.4903 0.8968
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.028 0.4903 0.8968
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0552 0.085
Echinococcus multilocularis Mastin 0.0075 0.099 0.1655
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0041 0.0331 0.0674
Echinococcus granulosus calpain A 0.0113 0.171 0.3001
Loa Loa (eye worm) hypothetical protein 0.0075 0.099 0.1667
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0494 0.0727
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0552 0.1126
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.099 0.1655
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0225 0.024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0143 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0444 0.0634
Loa Loa (eye worm) beta-lactamase 0.0035 0.0225 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0552 0.126
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2892 0.6599
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.022 0.1387
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0075 0.099 0.199
Echinococcus granulosus cathepsin L 0.0031 0.0143 0.0071
Leishmania major cathepsin L-like protease 0.0052 0.0552 0.3483
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0552 0.126
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0225 0.0459
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Echinococcus granulosus calpain 7 C02 family 0.0041 0.0331 0.0422
Leishmania major cathepsin L-like protease 0.0052 0.0552 0.3483
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0225 0.0425
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0266 0.358
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0567 0.0865
Echinococcus multilocularis calpain family protein 1, d 0.0079 0.1072 0.1808
Brugia malayi Cathepsin L-like precursor 0.0052 0.0552 0.1094
Onchocerca volvulus 0.0052 0.0552 0.131
Echinococcus granulosus calpain 5 0.0041 0.0331 0.0422
Loa Loa (eye worm) calpain family protein 1 0.0079 0.1072 0.182
Onchocerca volvulus 0.0067 0.0838 0.2454
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.4383 1
Leishmania major cathepsin L-like protease 0.0052 0.0552 0.3483
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0235 0.0537
Brugia malayi Bromodomain containing protein 0.0073 0.0955 0.1918
Schistosoma mansoni bromodomain containing protein 0.0062 0.0735 0.1179
Entamoeba histolytica cysteine protease, putative 0.0052 0.0552 0.3483
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2892 0.6599
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0143 0.0899
Onchocerca volvulus 0.0052 0.0552 0.131
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0235 0.0537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Onchocerca volvulus 0.0075 0.099 0.3064
Brugia malayi Cathepsin L-like precursor 0.0038 0.0273 0.0523
Brugia malayi Ets-domain containing protein 0.007 0.089 0.1786
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0225 0.0459
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0266 0.0301
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0552 0.0836
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1585 0.2778
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0494 0.1126
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0494 0.0727
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0225 0.0225
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1585 0.2778
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0113 0.171 0.3001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0235 0.048
Echinococcus multilocularis fk506 binding protein 0.0053 0.0561 0.0852
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.4383 0.8935
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0494 0.1007
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0266 0.0606
Leishmania major cathepsin L-like protease 0.0052 0.0552 0.3483
Schistosoma mansoni hypothetical protein 0.0171 0.2815 0.5065
Onchocerca volvulus 0.0075 0.099 0.3064
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0561 0.1279
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0494 0.3114
Schistosoma mansoni hypothetical protein 0.0309 0.5456 1
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0143 0.0899
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0075 0.099 0.1655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.0273 0.0523
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.4383 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0266 0.0542
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.0561 0.1112
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0567 0.0865
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Echinococcus granulosus cathepsin b 0.028 0.4903 0.8968
Echinococcus multilocularis Tolloid protein 1 0.004 0.0312 0.0387
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0266 0.0041
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0552 0.1126
Loa Loa (eye worm) hypothetical protein 0.0154 0.2501 0.4487
Brugia malayi Fli-1 protein 0.0212 0.3616 0.7365
Brugia malayi calpain family protein 1 0.0108 0.1617 0.3273
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1585 0.3232
Loa Loa (eye worm) hypothetical protein 0.0038 0.0273 0.0329
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0041 0.0331 0.1573
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0235 0.0445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0225 0.0225
Loa Loa (eye worm) calpain 0.0041 0.0331 0.0437
Brugia malayi mbt repeat family protein 0.0047 0.0444 0.0873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0552 0.126
Trypanosoma brucei glucosidase, putative 0.0035 0.022 0.083
Brugia malayi hypothetical protein 0.0075 0.099 0.199
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0552 0.0836
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.2564 0.4595
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0561 0.3119
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0331 0.0674
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0075 0.099 0.1655
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.0561 0.1112
Schistosoma mansoni hypothetical protein 0.0075 0.099 0.1655
Loa Loa (eye worm) bone morphogenetic protein 1b 0.004 0.0312 0.0402
Loa Loa (eye worm) ctsf protein 0.0052 0.0552 0.085
Loa Loa (eye worm) fli-1 protein 0.0212 0.3616 0.6567
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0331 0.2086
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Loa Loa (eye worm) hypothetical protein 0.0241 0.4167 0.7596
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0561 0.1144
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0235 0.0244
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0217 0.0209
Brugia malayi beta-lactamase family protein 0.0035 0.0225 0.0425
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0053 0.0561 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0235 0.1484
Brugia malayi Cathepsin L-like precursor 0.0052 0.0552 0.1094
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0053 0.0561 0.348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0143 0.0325
Brugia malayi Cathepsin L-like precursor 0.0052 0.0552 0.1094
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0494 0.0727
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2721 0.6209
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.099 0.1655
Trichomonas vaginalis immunophilin, putative 0.0053 0.0561 0.1279
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1585 0.2766
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.004 0.0312 0.0387
Schistosoma mansoni egf-like domain protein 0.004 0.0312 0.0387
Brugia malayi RNA, U transporter 1 0.0082 0.1124 0.2265
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0331 0.2086
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0552 0.9813
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0098 0.1422 0.3245
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0402
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.022 0.0414
Schistosoma mansoni hypothetical protein 0.0049 0.0493 0.0726
Echinococcus multilocularis snurportin 1 0.0309 0.5456 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0349 0.0472
Echinococcus multilocularis calpain 5 0.0041 0.0331 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0225 0.2701
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0494 0.2972
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.022 0.023
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0143 0.0071
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0053 0.0561 0.0343
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0402
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1585 0.2766
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0331 0.0674
Plasmodium vivax importin-beta 2, putative 0.0029 0.0105 0.0081
Echinococcus granulosus Mastin 0.0075 0.099 0.1655
Echinococcus multilocularis cysteine protease 0.0052 0.0552 0.0836
Schistosoma mansoni immunophilin 0.0045 0.0422 0.0593
Loa Loa (eye worm) trypsin family protein 0.0075 0.099 0.1667
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0266 0.0542
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0331 0.1573
Schistosoma mansoni calpain C (C02 family) 0.0041 0.0331 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Brugia malayi Fibulin-1 precursor 0.004 0.0312 0.0602
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0101 0.023
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.2564 0.4603
Echinococcus granulosus calpain 0.0041 0.0331 0.0422
Echinococcus multilocularis laminin 0.004 0.0312 0.0387
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.4383 1
Schistosoma mansoni hypothetical protein 0.0075 0.099 0.1655
Brugia malayi phosphofructokinase 0.0106 0.1585 0.3208
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0444 0.0634
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.028 0.4903 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0696 0.1119
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0225 0.0225
Onchocerca volvulus 0.0038 0.0273 0.0191
Echinococcus granulosus cathepsin l1 0.0038 0.0273 0.0314
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0143 0.0291
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0331 0.0674
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0225 0.0225
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0561 0.348
Onchocerca volvulus 0.0075 0.099 0.3064
Toxoplasma gondii cathepsin CPL 0.0052 0.0552 0.3415
Leishmania major peptidylprolyl isomerase-like protein 0.0053 0.0561 0.3538
Brugia malayi Cathepsin L-like precursor 0.0052 0.0552 0.1094
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0331 0.0674
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1585 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0225 0.0514
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0143 0.0256
Brugia malayi hypothetical protein 0.0154 0.2501 0.5083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0273 0.0329
Brugia malayi Trypsin family protein 0.0075 0.099 0.199
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0053 0.0561 0.3538
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0235 0.1484
Echinococcus granulosus Tolloid protein 1 0.004 0.0312 0.0387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Loa Loa (eye worm) hypothetical protein 0.0075 0.099 0.1667
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.022 0.0502
Echinococcus multilocularis hypothetical protein 0.0041 0.0331 0.0422
Echinococcus granulosus transmembrane protease serine 3 0.0075 0.099 0.1655
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Toxoplasma gondii calcium binding egf domain-containing protein 0.004 0.0312 0.1597
Echinococcus multilocularis cathepsin L 0.0031 0.0143 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Schistosoma mansoni ap endonuclease 0.0037 0.0266 0.0301
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0225 0.0864
Schistosoma mansoni calpain (C02 family) 0.0041 0.0331 0.0422
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0101 0.023
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1585 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0105 0.0055
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1585 0.3616
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0235 0.1017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0668 0.1054
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0561 0.1144
Schistosoma mansoni alpha glucosidase 0.0035 0.022 0.0215
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0552 0.1126
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0225 0.0514
Echinococcus granulosus laminin 0.004 0.0312 0.0387
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.0561 0.0866
Echinococcus multilocularis geminin 0.0171 0.2815 0.5065
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.099 0.1655
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0235 0.048
Loa Loa (eye worm) hypothetical protein 0.0108 0.1617 0.2837
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.2564 0.5211
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0143 0.0256
Toxoplasma gondii ABC1 family protein 0.0035 0.0225 0.094
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0224 0.0223
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0494 0.0741
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.089 0.1481
Schistosoma mansoni calpain-7 (C02 family) 0.0044 0.0386 0.0526
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0235 0.0244
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0101 0.0637
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1585 0.1391
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0561 1
Echinococcus granulosus geminin 0.0171 0.2815 0.5065
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0143 0.0899
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.2564 0.4595
Entamoeba histolytica calpain large subunit domain III containing protein 0.0028 0.0096 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0567 0.0879
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1585 0.2766
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Leishmania major cathepsin L-like protease 0.0052 0.0552 0.3483
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0273 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0331 0.1573
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0561 0.1144
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0422 0.0593
Loa Loa (eye worm) cathepsin B 0.0098 0.1422 0.2474
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0552 0.126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1585 0.3616
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.022 0.0448
Echinococcus multilocularis cysteine protease 0.0052 0.0552 0.0836
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0235 0.0244
Leishmania major cathepsin L-like protease 0.0052 0.0552 0.3483
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.0561 0.0852
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.3855 0.3713
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0235 0.0932
Brugia malayi Bromodomain containing protein 0.0037 0.0268 0.0513
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0266 0.0316
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0098 0.1422 0.29
Onchocerca volvulus 0.0154 0.2501 0.9117
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0494 0.1126
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.0561 0.1279
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0143 0.0291
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0444 0.0648
Giardia lamblia Cathepsin B precursor 0.0098 0.1422 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0143 0.0325
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0143 0.0899
Brugia malayi Trypsin-like protease protein 5 0.0075 0.099 0.199
Brugia malayi 6-phosphofructokinase 0.0106 0.1585 0.3208
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1585 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0561 0.1144
Echinococcus granulosus cathepsin b 0.028 0.4903 0.8968
Loa Loa (eye worm) FKBP5 protein 0.0053 0.0561 0.0866
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0273 0.0623
Echinococcus granulosus cathepsin l1 0.0052 0.0552 0.0836
Brugia malayi Trypsin family protein 0.0075 0.099 0.199
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0552 0.9813
Entamoeba histolytica hypothetical protein 0.0035 0.0217 0.1367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.4903 0.8968
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0143 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0552 0.126
Echinococcus granulosus calpain A 0.0041 0.0331 0.0422
Loa Loa (eye worm) hypothetical protein 0.0035 0.0225 0.024
Entamoeba histolytica cysteine protease, putative 0.0031 0.0143 0.0899
Schistosoma mansoni alpha-glucosidase 0.0135 0.2144 0.3811
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0552 0.0836
Brugia malayi Cathepsin L-like precursor 0.0052 0.0552 0.1094
Giardia lamblia Cathepsin B precursor 0.0098 0.1422 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Loa Loa (eye worm) hypothetical protein 0.0067 0.0838 0.1383
Loa Loa (eye worm) hypothetical protein 0.0035 0.0225 0.024
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.022 0.0502
Schistosoma mansoni alpha-glucosidase 0.0135 0.2144 0.3811
Loa Loa (eye worm) hypothetical protein 0.0075 0.099 0.1667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Brugia malayi beta-lactamase family protein 0.0035 0.0225 0.0425
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.4383 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0552 0.085
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0561 0.1279
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0224 0.0223
Toxoplasma gondii cathepsin B 0.0098 0.1422 1
Brugia malayi 6-phosphofructokinase 0.0106 0.1585 0.3208
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2721 0.6209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0273 0.0623
Echinococcus granulosus GA binding protein alpha chain 0.007 0.089 0.1468
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0113 0.171 0.3001
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1585 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0552 0.126
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0225 0.0514
Echinococcus multilocularis cathepsin b 0.028 0.4903 0.8968
Toxoplasma gondii exonuclease III APE 0.0037 0.0266 0.1246
Loa Loa (eye worm) hypothetical protein 0.004 0.0314 0.0405
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.3212 0.5807
Plasmodium vivax vivapain-2 0.0052 0.0552 0.9813
Leishmania major fk506-binding protein 1-like protein 0.0053 0.0561 0.3538
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.022 0.0502
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.4903 0.8968
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0113 0.171 0.3001
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.099 0.1655
Brugia malayi calpain 7 0.0041 0.0331 0.0641
Loa Loa (eye worm) hypothetical protein 0.0035 0.0225 0.024
Loa Loa (eye worm) hypothetical protein 0.0075 0.099 0.1667
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1585 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0331 0.0674
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0266 0.358
Brugia malayi hypothetical protein 0.0035 0.0217 0.0408
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.099 0.1655
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0552 0.3061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0552 0.126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0552 0.126
Brugia malayi calpain family protein 1 0.0108 0.1617 0.3273
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0494 0.1007
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1585 0.3616
Schistosoma mansoni immunophilin 0.0053 0.0561 0.0852
Brugia malayi cathepsin B-like cysteine proteinase 0.028 0.4903 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1585 0.1391
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.022 0.0901
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2721 0.6209

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.25 uM In vitro inhibitory concentration of compound against human thrombin ChEMBL. 12646027
IC50 (binding) = 0.25 uM In vitro inhibitory concentration of compound against human thrombin ChEMBL. 12646027

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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