Detailed information for compound 1986361

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.351 | Formula: C21H15F3N2O3
  • H donors: 2 H acceptors: 4 LogP: 3.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc(ccc1Oc1ccc(cc1)c1cccc(n1)C(CO)O)C(F)(F)F
  • InChi: 1S/C21H15F3N2O3/c22-21(23,24)15-6-9-20(14(10-15)11-25)29-16-7-4-13(5-8-16)17-2-1-3-18(26-17)19(28)12-27/h1-10,19,27-28H,12H2
  • InChiKey: IBYVOVYCXRENLI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii exonuclease III APE 0.0017 0.02 0.0348
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0489 0.2498
Loa Loa (eye worm) MH2 domain-containing protein 0.0107 0.1895 0.1895
Onchocerca volvulus 0.0011 0.0096 0.0055
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0217 0.0378
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0011 0.0096 0.0248
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Brugia malayi major facilitator superfamily protein 0.0016 0.0175 0.0175
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.02 0.02
Brugia malayi hypothetical protein 0.0016 0.0175 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0185 0.0476
Echinococcus multilocularis ATP binding cassette sub family G 0.0009 0.0049 0.0127
Brugia malayi MH2 domain containing protein 0.0007 0.002 0.002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0086 0.1492 0.3719
Brugia malayi Cam kinase protein 1 0.0034 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Schistosoma mansoni nuclear receptor 0.004 0.0642 0.3278
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.02 0.02
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0609 0.0609
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0733 0.0733
Brugia malayi hypothetical protein 0.0045 0.0733 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0541 0.1393
Brugia malayi Sugar transporter family protein 0.0016 0.0175 0.0175
Echinococcus multilocularis ATP binding cassette sub family G 0.0009 0.0049 0.0127
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.1492 0.1492
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0022 0.0057
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0175 0.6328
Loa Loa (eye worm) ABC transporter 0.0007 0.0024 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Loa Loa (eye worm) hypothetical protein 0.0045 0.0733 0.0733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0086 0.1492 0.1492
Echinococcus multilocularis ATP binding cassette sub family G 0.0009 0.0049 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0096 0.0248
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0086 0.1492 0.7616
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.02 0.0517
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0217 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0134 0.0345
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0217 0.0217
Leishmania major protein kinase, putative 0.0013 0.0136 0.0136
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0185 0.0476
Brugia malayi hypothetical protein 0.0032 0.0489 0.0489
Echinococcus multilocularis chromobox protein 1 0.0062 0.1057 0.2733
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0086 0.1492 0.1492
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus granulosus chromobox protein 1 0.0062 0.1057 0.2733
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0086 0.1492 0.3858
Schistosoma mansoni ABC transporter 0.0007 0.0024 0.0122
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0096
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0096 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0075 0.0194
Loa Loa (eye worm) sugar transporter 0.0016 0.0175 0.0175
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.02 0.7229
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0506 0.1303
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0642 0.1488
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0527 0.1357
Trypanosoma brucei glucose transporter, putative 0.0034 0.0527 0.0527
Trichomonas vaginalis chromobox protein, putative 0.0062 0.1057 0.2721
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0175 0.3575
Trypanosoma brucei glucose transporter, putative 0.0034 0.0527 0.0527
Brugia malayi nuclear hormone receptor 0.004 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0022 0.0057
Loa Loa (eye worm) hypothetical protein 0.0045 0.0733 0.0733
Schistosoma mansoni chromobox protein 0.0062 0.1057 0.5395
Loa Loa (eye worm) transcription factor SMAD2 0.0107 0.1895 0.1895
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0506 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.1492 0.1492
Echinococcus multilocularis General substrate transporter 0.0095 0.1668 0.4311
Brugia malayi MH1 domain containing protein 0.0007 0.002 0.002
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0175 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0086 0.1492 0.1492
Brugia malayi hypothetical protein 0.004 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Plasmodium vivax ABC transporter G family member 2, putative 0.0009 0.0049 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0527 0.1357
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0103 0.2107
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0217 0.0217
Brugia malayi Steroid receptor seven-up type 2 0.0086 0.1492 0.1492
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0642 0.0642
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0347 0.6849
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0519 0.1342
Entamoeba histolytica hypothetical protein 0.001 0.0075 0.1452
Trypanosoma brucei glucose transporter, putative 0.0034 0.0527 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0527 0.1357
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0609 0.0609
Loa Loa (eye worm) steroid hormone receptor 0.0086 0.1492 0.1492
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0175 0.0175
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.001 0.0075 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0075 0.0194
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.1492 0.7616
Loa Loa (eye worm) hypothetical protein 0.0086 0.1492 0.1492
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0175 0.0175
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0519 0.0519
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0642 0.1661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0397 0.2025
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0642 0.1661
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0349 0.0899
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0217 0.4291
Echinococcus multilocularis chromobox protein 2 0.001 0.0075 0.0195
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0175 0.0894
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0217 0.0217
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.02 0.4085
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0086 0.1492 0.7616
Entamoeba histolytica recQ family DNA helicase 0.0009 0.0053 0.1029
Plasmodium falciparum mitogen-activated protein kinase 2 0.0178 0.3238 0.3724
Loa Loa (eye worm) hypothetical protein 0.0146 0.2633 0.2633
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0519 0.0597
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0175 0.0451
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0086 0.1492 0.1492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0086 0.1492 0.1492
Schistosoma mansoni smad1 5 8 and 0.0007 0.002 0.0103
Brugia malayi hypothetical protein 0.001 0.0075 0.0075
Echinococcus multilocularis bloom syndrome protein 0.0018 0.0217 0.0561
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0277 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0397 0.0397
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.02 0.023
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0527 0.1357
Schistosoma mansoni chromobox protein 0.001 0.0075 0.0384
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0175 0.0451
Loa Loa (eye worm) hypothetical protein 0.0086 0.1492 0.1492
Trypanosoma brucei glucose transporter 1E 0.0034 0.0527 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.1492 0.1492
Brugia malayi hypothetical protein 0.0212 0.3868 0.3868
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0175 0.6328
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0009 0.0049 0.0049
Mycobacterium ulcerans putative regulatory protein 0.0032 0.049 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0519 0.0519
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0009 0.0049 0.1002
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Brugia malayi nuclear receptor RXR 0.0045 0.0733 0.0733
Schistosoma mansoni ap endonuclease 0.0017 0.02 0.1021
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0011 0.0096 0.0249
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0038 0.0589 0.3005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0086 0.1492 0.3858
Echinococcus granulosus survival motor neuron protein 1 0.0212 0.3868 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0733 0.0733
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0217 0.0561
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0086 0.1492 0.3858
Trichomonas vaginalis DNA helicase recq, putative 0.0018 0.0217 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Onchocerca volvulus Bile acid receptor homolog 0.0086 0.1492 0.3719
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0175 0.0175
Trypanosoma brucei glucose transporter, putative 0.0034 0.0527 0.0527
Schistosoma mansoni DNA helicase recq5 0.0018 0.0217 0.1108
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0217 0.0217
Brugia malayi Bloom's syndrome protein homolog 0.0018 0.0217 0.0217
Leishmania major glucose transporter, lmgt3 0.0034 0.0527 0.0527
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0368 0.0951
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus multilocularis survival motor neuron protein 1 0.0212 0.3868 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0519 0.0597
Loa Loa (eye worm) hypothetical protein 0.001 0.0075 0.0075
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0175 0.0175
Schistosoma mansoni nuclear receptor 0.004 0.0642 0.3278
Onchocerca volvulus 0.0016 0.0175 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0347 0.0347
Schistosoma mansoni glucose transport protein 0.011 0.1959 1
Entamoeba histolytica recQ family helicase, putative 0.0009 0.0047 0.0904
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0609 0.0609
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0519 0.0903
Brugia malayi Pre-SET motif family protein 0.0027 0.0397 0.0397
Brugia malayi steroid hormone receptor 0.0086 0.1492 0.1492
Schistosoma mansoni glucose transport protein 0.011 0.1959 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0506 0.9752
Loa Loa (eye worm) hypothetical protein 0.0275 0.5054 0.5054
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0178 0.3238 0.3724
Onchocerca volvulus 0.0016 0.0175 0.0262
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0506 0.2583
Brugia malayi nuclear receptor NHR-67 0.004 0.0642 0.0642
Onchocerca volvulus 0.0016 0.0175 0.0262
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Echinococcus granulosus cpg binding protein 0.0027 0.0395 0.102
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0733 0.0733
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0217
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.005 0.005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0489 0.1265
Onchocerca volvulus 0.0038 0.0589 0.1348
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0096 0.0248
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0277 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0733 0.3742
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Schistosoma mansoni hypothetical protein 0.001 0.0075 0.0384
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0642 0.1661
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0101 0.1773 0.1773
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0096 0.0248
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0086 0.1492 0.3858
Entamoeba histolytica hypothetical protein 0.001 0.0075 0.1452
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0185 0.0476
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0527 0.1357
Brugia malayi SET domain containing protein 0.0012 0.0104 0.0104
Schistosoma mansoni steroid hormone receptor ad4bp 0.0086 0.1492 0.7616
Echinococcus multilocularis Smad4 0.0007 0.002 0.0052
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.0075 0.0194
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0133
Onchocerca volvulus 0.004 0.0642 0.1488
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0086 0.1492 0.1492
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.02 0.0517
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.02 0.02
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0185 0.0476
Echinococcus granulosus aryl hydrocarbon receptor 0.0011 0.0096 0.0249
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0053 0.0273
Brugia malayi ecdysone receptor 0.004 0.0642 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0075 0.0194
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0347 0.0347
Brugia malayi Associated with TFs and helicases family protein 0.001 0.0075 0.0075
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0642 0.1661
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Echinococcus granulosus Chromobox protein 3 0.001 0.0075 0.0195
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0519 0.1342
Onchocerca volvulus 0.0016 0.0175 0.0262
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.0733 0.3742
Echinococcus granulosus chromobox protein 2 0.001 0.0075 0.0195
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.002 0.0103
Echinococcus granulosus single minded 2 0.0032 0.049 0.1267
Schistosoma mansoni aryl hydrocarbon receptor 0.0044 0.0703 0.3587
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0591 0.1522
Brugia malayi nuclear receptor RXR 0.004 0.0642 0.0642
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0347 0.0603
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0453
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0035 0.0541 0.1223
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0175 0.0175
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0642 0.3278
Brugia malayi Valyl-tRNA synthetase 0.001 0.0075 0.0075
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0187 0.3401 0.3401
Entamoeba histolytica hypothetical protein 0.0032 0.0489 0.9431
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0527 0.1357
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0367 0.0367
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0075 0.0194
Loa Loa (eye worm) Smad1 0.0007 0.002 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.1492 0.1492
Onchocerca volvulus 0.004 0.0642 0.1488
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.1959 0.5066
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0011 0.0096 0.0249
Echinococcus granulosus bloom syndrome protein 0.0018 0.0217 0.0561
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0538 1 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0527 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0541 0.1393
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.3868 0.3868
Echinococcus granulosus chromobox protein 1 0.0062 0.1057 0.2733
Onchocerca volvulus 0.0016 0.0175 0.0262
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0011 0.0096 0.0096
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0347 0.6849
Onchocerca volvulus 0.001 0.0075 0.000000055302
Leishmania major glucose transporter, lmgt2 0.0034 0.0527 0.0527
Leishmania major protein kinase, putative 0.0034 0.0519 0.0519
Onchocerca volvulus 0.0016 0.0175 0.0262
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0527 0.0527
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0027 0.0397 0.1026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0086 0.1492 0.1492
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0009 0.0049 0.0049
Brugia malayi CHD4 protein 0.0012 0.0103 0.0103
Brugia malayi Sugar transporter family protein 0.011 0.1959 0.1959
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.02 0.02
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0086 0.1492 0.1492
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Plasmodium vivax hypothetical protein, conserved 0.001 0.0075 0.0087
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0347 0.0896
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0134 0.0345
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0519 0.0519
Plasmodium vivax hexose transporter 0.011 0.1959 0.2253
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0277 0.5469
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Schistosoma mansoni smad1 5 8 and 0.0007 0.002 0.0103
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.0696 0.0696
Leishmania major C-8 sterol isomerase-like protein 0.0538 1 1
Trypanosoma cruzi Emopamil binding protein, putative 0.0101 0.1773 0.1773
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Brugia malayi Nuclear hormone receptor E75 0.004 0.0642 0.0642
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0011 0.0096 0.0096
Toxoplasma gondii histone lysine methyltransferase SET1 0.005 0.0819 0.1424
Schistosoma mansoni protein kinase 0.0034 0.0519 0.2648
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0185 0.0476
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0217 0.025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.1492 0.1492
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0642 0.1661
Leishmania major hypothetical protein, conserved 0.0016 0.0175 0.0175
Mycobacterium ulcerans sugar transporter 0.0016 0.0175 0.3575
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0519 0.0597
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0519 0.0597
Trypanosoma brucei sugar transporter, putative 0.0016 0.0175 0.0175
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0047 0.0082
Echinococcus multilocularis FTZ F1 alpha 0.0086 0.1492 0.3858
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0347 0.1769
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0133
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.001 0.0075 0.1452
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0011 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0075 0.0075
Brugia malayi CXXC zinc finger family protein 0.0026 0.0367 0.0367
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0027 0.0397 0.1026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0397 0.2025
Trypanosoma cruzi ABC transporter, putative 0.0009 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0086 0.1492 0.1492
Onchocerca volvulus 0.0016 0.0175 0.0262
Loa Loa (eye worm) hypothetical protein 0.001 0.0075 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus granulosus ATP binding cassette sub family G 0.0009 0.0049 0.0127
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.0733 0.0733
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0175 0.0175
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0175 0.0453
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trypanosoma brucei ABC transporter, putative 0.0009 0.0049 0.0049
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0011 0.0096 0.2776
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0217 0.0378
Giardia lamblia ABC transporter 0.0009 0.0047 0.0931
Schistosoma mansoni nuclear hormone receptor 0.0086 0.1492 0.7616
Onchocerca volvulus 0.0016 0.0175 0.0262
Echinococcus granulosus histone lysine methyltransferase setb 0.0027 0.0397 0.1026
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0009 0.0049 0.025
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0103 0.0103
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0009 0.0047 0.0054
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0453
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0347 0.7076
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0349 0.0899
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0136 0.0136
Brugia malayi hypothetical protein 0.004 0.0642 0.0642
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0347 0.0896
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0519 0.0519
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.02 0.023
Schistosoma mansoni chromobox protein 0.0062 0.1057 0.5395
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0506 0.1309
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.004 0.0642 0.1661
Trichomonas vaginalis DNA helicase recq, putative 0.0018 0.0217 0.0559
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0096 0.0248
Brugia malayi Smad1 0.0007 0.002 0.002
Schistosoma mansoni survival motor neuron protein 0.0043 0.0696 0.3552
Onchocerca volvulus 0.0213 0.3885 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0469 0.8696 1
Schistosoma mansoni protein kinase 0.0034 0.0519 0.2648
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.1492 0.1492
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.002 0.002
Trypanosoma brucei glucose transporter 2A 0.0034 0.0527 0.0527
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.1492 0.3858
Entamoeba histolytica hypothetical protein 0.0032 0.0489 0.9431
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.0733 0.1896
Trypanosoma brucei glucose transporter, putative 0.0034 0.0527 0.0527
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0642 0.1661
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0096 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0642 0.0642
Brugia malayi Sugar transporter family protein 0.0016 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Onchocerca volvulus 0.0086 0.1492 0.3719
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0519 0.1342
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0185 0.0476
Onchocerca volvulus 0.0016 0.0175 0.0262
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0642 0.0642
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0103 0.0266
Echinococcus granulosus ATP binding cassette sub family G 0.0009 0.0049 0.0127
Onchocerca volvulus 0.0043 0.0696 0.1629
Loa Loa (eye worm) hypothetical protein 0.0086 0.1492 0.1492
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Brugia malayi Pre-SET motif family protein 0.0187 0.3401 0.3401
Schistosoma mansoni DNA helicase recq1 0.0018 0.0217 0.1108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0506 0.0506
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.001 0.0075 0.1452
Schistosoma mansoni ap endonuclease 0.0017 0.02 0.1021
Giardia lamblia Sugar-proton symporter 0.0016 0.0175 0.346
Schistosoma mansoni nuclear hormone receptor 0.004 0.0642 0.3278
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0453
Trypanosoma brucei glucose transporter, putative 0.0034 0.0527 0.0527
Onchocerca volvulus 0.0016 0.0175 0.0262
Loa Loa (eye worm) hypothetical protein 0.0086 0.1492 0.1492
Loa Loa (eye worm) helicase 0.001 0.0075 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0347 0.7076
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0096 0.0248
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.001 0.0075 0.0087
Entamoeba histolytica hypothetical protein 0.0032 0.0489 0.9431
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0506 0.2583
Plasmodium falciparum heterochromatin protein 1 0.001 0.0075 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0185 0.0476
Echinococcus multilocularis mothers against decapentaplegic 5 0.0007 0.002 0.0052
Trypanosoma brucei glucose transporter, putative 0.0034 0.0527 0.0527
Echinococcus granulosus TGF beta signal transducer SmadC 0.0007 0.002 0.0052
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0609 0.0609
Onchocerca volvulus 0.0016 0.0175 0.0262
Schistosoma mansoni thyroid hormone receptor 0.0086 0.1492 0.7616
Loa Loa (eye worm) hypothetical protein 0.0035 0.0541 0.0541
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0642 0.1661
Trypanosoma brucei ATP-binding cassette protein, putative 0.0009 0.0049 0.0049
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0519 0.0597
Schistosoma mansoni chromobox protein 0.001 0.0075 0.0384
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0175 0.0175
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0894
Schistosoma mansoni zinc finger protein 0.004 0.0642 0.3278
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0519 0.1342
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0075 0.0194
Trypanosoma brucei glucose transporter, putative 0.0034 0.0527 0.0527
Trypanosoma brucei Emopamil binding protein, putative 0.0101 0.1773 0.1773
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0009 0.0053 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Onchocerca volvulus 0.0027 0.0399 0.085
Schistosoma mansoni hypothetical protein 0.0043 0.0696 0.3552
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0642 0.0642
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0527 0.0527
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0591 0.1522
Echinococcus multilocularis thyroid hormone receptor alpha 0.0086 0.1492 0.3858
Loa Loa (eye worm) hypothetical protein 0.001 0.0075 0.0075
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0347 0.0347
Loa Loa (eye worm) hypoxia-induced factor 1 0.0135 0.242 0.242
Leishmania major hypothetical protein, conserved 0.0101 0.1773 0.1773
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.048 0.124
Trypanosoma cruzi hexose transporter 0.0034 0.0527 0.0527
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.1959 0.5066
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0642 0.1661
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0519 0.1342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0086 0.1492 0.1492
Brugia malayi ecdysteroid receptor 0.0086 0.1492 0.1492
Loa Loa (eye worm) hypothetical protein 0.0033 0.0506 0.0506
Onchocerca volvulus 0.0016 0.0175 0.0262
Brugia malayi major facilitator superfamily protein 0.0016 0.0175 0.0175
Trichomonas vaginalis chromobox protein, putative 0.0062 0.1057 0.2721
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0009 0.0049 0.0085
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0027 0.0397 0.069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.1492 0.3858
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0096 0.0248
Toxoplasma gondii facilitative glucose transporter GT1 0.011 0.1959 0.3408
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.001 0.0075 0.1452
Echinococcus multilocularis smad 0.0007 0.002 0.0052
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0217 0.0217
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0086 0.1492 0.3858
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0086 0.1492 0.1492
Trichomonas vaginalis chromobox protein, putative 0.001 0.0075 0.0194
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0009 0.0049 0.1002
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0453
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0086 0.1492 0.3858
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0096 0.0248
Schistosoma mansoni RAR-like nuclear receptor 0.0086 0.1492 0.7616
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.1959 0.5066
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0175 0.0453
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0506 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.1959 0.5066
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Loa Loa (eye worm) hypothetical protein 0.0045 0.0733 0.0733
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0347 0.0347
Brugia malayi chromobox protein homolog 3 0.0035 0.0541 0.0541
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0086 0.1492 0.3858
Echinococcus multilocularis transfer RNA-Lys 0.0032 0.049 0.1267
Brugia malayi hypoxia-induced factor 1 0.0135 0.242 0.242
Chlamydia trachomatis proline--tRNA ligase 0.0012 0.0103 0.2978
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0086 0.1492 0.7616
Schistosoma mansoni cpg binding protein 0.0027 0.0395 0.2014
Brugia malayi bHLH-PAS transcription factor 0.0032 0.049 0.049
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0506 0.0506
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0519 0.0903
Trichomonas vaginalis chromobox protein, putative 0.001 0.0075 0.0194
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0126 0.0325
Onchocerca volvulus 0.0032 0.049 0.1088
Schistosoma mansoni single-minded 0.0044 0.0703 0.3587
Onchocerca volvulus 0.0101 0.1773 0.4455
Echinococcus granulosus FTZ F1 alpha 0.0086 0.1492 0.3858
Loa Loa (eye worm) hypothetical protein 0.0034 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0009 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.02 0.02
Schistosoma mansoni protein kinase 0.0034 0.0519 0.2648
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.001 0.0075 0.0195
Entamoeba histolytica ABC transporter, putative 0.0009 0.0049 0.0945
Entamoeba histolytica protein kinase, putative 0.0034 0.0519 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.001 0.0075 0.0384
Trichomonas vaginalis chromobox protein, putative 0.001 0.0075 0.0194
Toxoplasma gondii protein kinase, putative 0.0312 0.5749 1
Brugia malayi MH2 domain containing protein 0.0107 0.1895 0.1895
Brugia malayi hypothetical protein 0.0016 0.0175 0.0175
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0347 0.0399
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0347 0.0892
Trichomonas vaginalis Heterochromatin protein, putative 0.001 0.0075 0.0194
Schistosoma mansoni hypothetical protein 0.0007 0.0022 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0086 0.1492 0.7616
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.02 0.0515
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0086 0.1492 0.3858
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Brugia malayi Nuclear hormone receptor E75 0.004 0.0642 0.0642
Plasmodium vivax sugar transporter, putative 0.0016 0.0175 0.0201
Brugia malayi hypothetical protein 0.0045 0.0733 0.0733
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0009 0.0053 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0022 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.02 1
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0453
Onchocerca volvulus 0.0016 0.0175 0.0262
Loa Loa (eye worm) heterochromatin protein 1 0.0062 0.1057 0.1057
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0175 0.8753
Schistosoma mansoni nuclear hormone receptor 0.004 0.0642 0.3278
Echinococcus multilocularis ecdysone induced protein 78C 0.0086 0.1492 0.3858
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0591 0.1354
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus multilocularis sodium channel protein 0.0045 0.0735 0.19
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0053 0.0053
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0011 0.0096 0.0096
Echinococcus granulosus Chromo domain 0.001 0.0075 0.0195
Loa Loa (eye worm) hypothetical protein 0.0086 0.1492 0.1492
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0022 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Onchocerca volvulus Protein ultraspiracle homolog 0.0086 0.1492 0.3719
Brugia malayi hypothetical protein 0.0016 0.0175 0.0175
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0489 0.1265
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0045 0.0735 0.0735
Trichomonas vaginalis hypothetical protein 0.001 0.0075 0.0194
Echinococcus granulosus smad 0.0007 0.002 0.0052
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0519 0.1342
Onchocerca volvulus 0.0026 0.0367 0.0766
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.1959 0.5066
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0519 0.1342
Loa Loa (eye worm) DR-78 0.004 0.0642 0.0642
Brugia malayi tailless protein 0.004 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0027 0.0399 0.0399
Brugia malayi ABC transporter family protein 0.0007 0.0024 0.0024
Plasmodium falciparum protein kinase 7 0.0312 0.5749 0.6612
Trypanosoma brucei C-8 sterol isomerase, putative 0.0538 1 1
Trypanosoma cruzi Emopamil binding protein, putative 0.0101 0.1773 0.1773
Echinococcus granulosus General substrate transporter 0.0095 0.1668 0.4311
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0101 0.1773 0.1773
Onchocerca volvulus 0.0016 0.0175 0.0262
Plasmodium vivax heterochromatin protein 1, putative 0.001 0.0075 0.0087
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0347 0.1769
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0347 0.0399
Loa Loa (eye worm) hypothetical protein 0.001 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.004 0.0642 0.0642
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.1492 0.1492
Loa Loa (eye worm) hypothetical protein 0.0027 0.0389 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0086 0.1492 0.1492
Echinococcus granulosus Smad4 0.0007 0.002 0.0052
Entamoeba histolytica protein kinase, putative 0.0034 0.0519 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0175 0.0175
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0519 0.1336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0075 0.0194
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0101 0.1773 0.1773
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.02 0.02
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0642 0.1661
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0175 0.0175
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.02 0.3954
Loa Loa (eye worm) hypothetical protein 0.0086 0.1492 0.1492
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0894
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0047 0.0239
Brugia malayi nuclear hormone receptor 0.0086 0.1492 0.1492
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.1492 0.3858
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0217 0.0561
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0519 0.1342
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0103 0.0525
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.001 0.0075 0.0087
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.02 0.0515
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0086 0.1492 0.1492
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0086 0.1492 0.1492
Echinococcus multilocularis aryl hydrocarbon receptor 0.0011 0.0096 0.0249
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.001 0.0075 0.0131
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0185 0.0476
Loa Loa (eye worm) hypothetical protein 0.001 0.0075 0.0075
Schistosoma mansoni glucose transport protein 0.011 0.1959 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0056 0.0928 0.4737
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.1959 0.5066
Mycobacterium leprae Possible regulatory protein 0.0011 0.0096 0.1901
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0519 0.0903
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0642 0.1661
Brugia malayi nuclear receptor NHR-88 0.0086 0.1492 0.1492
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0175 0.3575
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0086 0.1492 0.7616
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Entamoeba histolytica hypothetical protein 0.0025 0.0347 0.6679
Toxoplasma gondii sugar transporter ST1 0.0016 0.0175 0.0305
Plasmodium falciparum protein kinase 6 0.0469 0.8696 1
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0609 0.0701
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0053 0.0093
Echinococcus multilocularis Chromo domain 0.001 0.0075 0.0195
Brugia malayi PAS domain containing protein 0.0044 0.0703 0.0703
Brugia malayi conserved hypotetical protein 0.004 0.0642 0.0642
Entamoeba histolytica recQ family helicase, putative 0.0018 0.0217 0.4184
Echinococcus multilocularis cpg binding protein 0.0027 0.0395 0.102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0347 0.0347
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0175 0.0453
Schistosoma mansoni hypothetical protein 0.0032 0.0489 0.2498
Echinococcus granulosus mothers against decapentaplegic 5 0.0007 0.002 0.0052
Schistosoma mansoni retinoic acid receptor RXR 0.0086 0.1492 0.7616
Brugia malayi Type III restriction enzyme, res subunit family protein 0.001 0.0075 0.0075
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0086 0.1492 0.3858
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0217 0.0561
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0136 0.0136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.1492 0.3858
Leishmania major glucose transporter, lmgt1 0.0034 0.0527 0.0527
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0235 0.0235
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0642 0.0642
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0506 0.1309
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0506 0.0506
Treponema pallidum ATP-dependent DNA helicase 0.0009 0.0053 0.2669
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0217 0.025
Brugia malayi photoreceptor-specific nuclear receptor 0.0086 0.1492 0.1492
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.001 0.0075 0.0195
Onchocerca volvulus 0.0016 0.0175 0.0262
Schistosoma mansoni hypothetical protein 0.011 0.1959 1
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0642 0.3278
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0642 0.0642
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0175 0.0175
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0527 0.0527
Schistosoma mansoni chromodomain helicase DNA binding protein 0.001 0.0075 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0086 0.1492 0.1492
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0136 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0075 0.0194
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0175 0.0453
Loa Loa (eye worm) RecQ helicase 0.0018 0.0217 0.0217
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0053 0.0053
Schistosoma mansoni smad1 5 8 and 0.0007 0.002 0.0103
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0519 0.0597
Brugia malayi nuclear receptor NHR-88 0.004 0.0642 0.0642
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0051 0.0051
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.029 0.0745
Trichomonas vaginalis set domain proteins, putative 0.0213 0.3885 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0175 0.3575
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.1959 0.5066
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0453
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0519 0.0597
Brugia malayi Heterochromatin protein 1 0.0062 0.1057 0.1057
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0007 0.002 0.0052
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0347 1
Echinococcus multilocularis chromobox protein 1 0.0062 0.1057 0.2733
Plasmodium vivax SET domain protein, putative 0.0027 0.0397 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.1492 0.1492
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0096 0.0248
Brugia malayi MH1 domain containing protein 0.0007 0.002 0.002
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0217 0.0561
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0175 0.0305
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0519 0.0597
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0642 0.1488
Toxoplasma gondii sugar transporter ST2 0.0016 0.0175 0.0305
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0397 0.2025
Schistosoma mansoni thyroid hormone receptor 0.0086 0.1492 0.7616
Loa Loa (eye worm) sugar transporter 0.011 0.1959 0.1959
Plasmodium vivax hypothetical protein, conserved 0.001 0.0075 0.0087
Leishmania major protein kinase, putative 0.0013 0.0136 0.0136
Schistosoma mansoni cpg binding protein 0.0027 0.0395 0.2014
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.001 0.0075 0.0131
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0609 0.0701
Brugia malayi Protein cec-1. 0.001 0.0075 0.0075
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.0075 0.0194
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Onchocerca volvulus 0.0016 0.0175 0.0262
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0519 0.0597
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0178 0.3238 0.5632
Loa Loa (eye worm) hypothetical protein 0.0045 0.0733 0.0733
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0538 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0009 0.0049 0.1002
Schistosoma mansoni smad 0.0007 0.002 0.0103
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0453
Schistosoma mansoni glucose transporter 0.0016 0.0175 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0175 0.0451
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.011 0.1959 0.5066
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0527 0.0527
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0453
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0009 0.0049 0.0049
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.0642 0.3278
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0007 0.0022 0.0792
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0642 0.1661
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0519 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Brugia malayi M-phase phosphoprotein, mpp8 0.001 0.0075 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0075 0.0194
Schistosoma mansoni Smad4 0.0007 0.002 0.0103
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.048 0.124
Toxoplasma gondii sugar transporter ST3 0.0016 0.0175 0.0305
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus granulosus ATP binding cassette sub family G 0.0009 0.0049 0.0127
Echinococcus multilocularis Chromobox protein 3 0.001 0.0075 0.0195
Loa Loa (eye worm) hypothetical protein 0.001 0.0075 0.0075
Plasmodium falciparum ABC transporter G family member 2 0.0009 0.0049 0.0056
Schistosoma mansoni cpg binding protein 0.0026 0.0367 0.1874
Echinococcus granulosus sodium channel protein 0.0045 0.0735 0.19
Brugia malayi MH2 domain containing protein 0.0007 0.002 0.002
Brugia malayi hypothetical protein 0.0146 0.2633 0.2633
Trichomonas vaginalis DNA helicase recq1, putative 0.0018 0.0217 0.0559
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0609 0.106
Onchocerca volvulus Putative transporter 0.0016 0.0175 0.0262
Entamoeba histolytica hypothetical protein 0.001 0.0075 0.1452
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0045 0.0735 0.19
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0075 0.0194
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0022 0.0057
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0103 0.0266
Echinococcus granulosus ecdysone induced protein 78C 0.0086 0.1492 0.3858
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.02 0.3856
Entamoeba histolytica hypothetical protein 0.0032 0.0489 0.9431
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.0733 0.1896
Giardia lamblia Hexose transporter 0.0016 0.0175 0.346
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0103 0.5159
Plasmodium falciparum hexose transporter 0.011 0.1959 0.2253
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.0642 0.0642
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.011 0.1959 0.5044
Schistosoma mansoni coup transcription factor 0.0086 0.1492 0.7616
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.001 0.0075 0.0384
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0527 0.1357

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 520 nM BindingDB_Patents: FLIPR Assay. Recombinant Nav1.7 Cell Line: In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Accession No. NM__002977). The cell line was provided by investigators at Yale University (Cummins et al, J. Neurosci. 18(23): 9607-9619 (1998)). For dominant selection of the Nav1.7-expressing clones, the expression plasmid co-expressed the neomycin resistance gene. The cell line was constructed in the human embryonic kidney cell line, HEK293, under the influence of the CMV major late promoter, and stable clones were selected using limiting dilution cloning and antibiotic selection using the neomycin analogue, G418. Recombinant beta and gamma subunits were not introduced into this cell line. Additional cell lines expressing recombinant Nav1.7 cloned from other species can also be used, alone or in combination with various beta subunits, gamma subunits or chaperones.Non-Recombinant Cell Lines Expressing Native Nav1. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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