Detailed information for compound 1986365

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.351 | Formula: C21H15F3N2O3
  • H donors: 2 H acceptors: 4 LogP: 3.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](c1cccc(n1)c1ccc(cc1)Oc1ccc(c(c1)C#N)C(F)(F)F)O
  • InChi: 1S/C21H15F3N2O3/c22-21(23,24)17-9-8-16(10-14(17)11-25)29-15-6-4-13(5-7-15)18-2-1-3-19(26-18)20(28)12-27/h1-10,20,27-28H,12H2/t20-/m0/s1
  • InChiKey: PZWDNPWXMCKKGM-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.02 0.4085
Mycobacterium ulcerans putative regulatory protein 0.0034 0.049 1
Loa Loa (eye worm) nuclear hormone receptor 0.0007 0.0012 0.0012
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0008 0.0027 0.007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0156 0.0156
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0075 0.0087
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0047 0.0239
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0133
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0008 0.0027 0.007
Echinococcus granulosus Nuclear hormone receptor HR96 0.0007 0.0012 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0134 0.0345
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0.0096 0.2776
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0007 0.0012 0.003
Giardia lamblia Hexose transporter 0.0016 0.0175 0.346
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0027 0.0027
Trypanosoma brucei C-8 sterol isomerase, putative 0.0565 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.1959 0.5044
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0096 0.0248
Echinococcus granulosus Chromobox protein 3 0.0011 0.0075 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0156 0.0156
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0012 0.006
Echinococcus multilocularis cpg binding protein 0.0029 0.0395 0.102
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0156
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0217 0.0559
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.1959 0.5066
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0075 0.0087
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0506 0.1309
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0096 0.0248
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0075
Brugia malayi bHLH-PAS transcription factor 0.0034 0.049 0.049
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.002 0.002
Echinococcus granulosus sodium channel protein 0.0045 0.0695 0.1796
Schistosoma mansoni glucose transport protein 0.0116 0.1959 1
Toxoplasma gondii exonuclease III APE 0.0018 0.02 0.0348
Brugia malayi hypothetical protein 0.0154 0.2633 0.2633
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0007 0.0012 0.003
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0519 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0349 0.0899
Mycobacterium ulcerans sugar transporter 0.0016 0.0175 0.3575
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0519 0.0519
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0009 0.0049 0.0049
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0156 0.0402
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0156 0.0402
Trypanosoma brucei glucose transporter, putative 0.0036 0.0527 0.0527
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0007 0.0012 0.006
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0075 0.0195
Trypanosoma brucei ABC transporter, putative 0.0009 0.0049 0.0049
Onchocerca volvulus 0.0016 0.0175 0.0422
Entamoeba histolytica recQ family DNA helicase 0.001 0.0053 0.1029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0541 0.0541
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0185 0.0476
Chlamydia trachomatis proline--tRNA ligase 0.0012 0.0103 0.2978
Loa Loa (eye worm) hypothetical protein 0.0026 0.0347 0.0347
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0096 0.0248
Brugia malayi steroid hormone receptor 0.0015 0.0156 0.0156
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0116 0.1959 0.5066
Brugia malayi nuclear receptor RXR 0.0007 0.0012 0.0012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0527 0.0527
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0103 0.0103
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0527 0.1357
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0175 0.0175
Giardia lamblia Sugar-proton symporter 0.0016 0.0175 0.346
Onchocerca volvulus 0.0016 0.0175 0.0422
Echinococcus granulosus ATP binding cassette sub family G 0.0009 0.0049 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0156 0.0156
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0156 0.0156
Plasmodium vivax ABC transporter G family member 2, putative 0.0009 0.0049 0.0056
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0051 0.0051
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0347 0.0347
Plasmodium falciparum mitogen-activated protein kinase 2 0.0187 0.3238 0.3724
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.02 0.0515
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0506 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0116 0.1959 0.5066
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0609 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0075 0.0194
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0009 0.0049 0.1002
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0096 0.0248
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0007 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Loa Loa (eye worm) heterochromatin protein 1 0.0066 0.1057 0.1057
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0217 0.0217
Brugia malayi Sugar transporter family protein 0.0016 0.0175 0.0175
Brugia malayi hypothetical protein 0.0016 0.0175 0.0175
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0075 0.0087
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0609 0.0609
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0009 0.0049 0.1002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0037 0.0541 0.1367
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0175 0.0453
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0506 0.1309
Plasmodium falciparum protein kinase 6 0.0492 0.8696 1
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0347 0.0347
Brugia malayi nuclear hormone receptor family member odr-7 0.0007 0.0012 0.0012
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0096 0.0096
Brugia malayi Sugar transporter family protein 0.0016 0.0175 0.0175
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0156 0.0402
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0397 0.1026
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0519 0.1342
Plasmodium falciparum ABC transporter G family member 2 0.0009 0.0049 0.0056
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0175 0.0305
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Schistosoma mansoni chromobox protein 0.0011 0.0075 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0156 0.0156
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0519 0.0597
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.002 0.0103
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0156 0.0794
Onchocerca volvulus 0.0011 0.0075 0.0164
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0347 0.0347
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.02 0.02
Schistosoma mansoni zinc finger protein 0.0007 0.0012 0.006
Loa Loa (eye worm) Smad1 0.0008 0.002 0.002
Onchocerca volvulus 0.0223 0.3885 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0027
Brugia malayi Heterochromatin protein 1 0.0066 0.1057 0.1057
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0453
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0156 0.0794
Brugia malayi Smad1 0.0008 0.002 0.002
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0347 0.1769
Schistosoma mansoni hypothetical protein 0.0116 0.1959 1
Brugia malayi CXXC zinc finger family protein 0.0027 0.0367 0.0367
Echinococcus multilocularis smad 0.0008 0.002 0.0052
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0217 0.0217
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0156 0.0794
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0397 0.2025
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0075 0.0087
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0096 0.0248
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0519 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0156 0.0156
Onchocerca volvulus Protein ultraspiracle homolog 0.0015 0.0156 0.0372
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0527 0.0527
Onchocerca volvulus 0.0039 0.0589 0.149
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0022 0.0112
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0453
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0175 0.0894
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0175 0.6328
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0156 0.0156
Echinococcus granulosus ATP binding cassette sub family G 0.0009 0.0049 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Schistosoma mansoni cpg binding protein 0.0029 0.0395 0.2014
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0527 0.0527
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0185 0.0476
Brugia malayi hypothetical protein 0.0007 0.0012 0.0012
Echinococcus multilocularis chromobox protein 1 0.0066 0.1057 0.2733
Onchocerca volvulus 0.0105 0.1773 0.4546
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.002 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0506 0.1303
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.1959 0.5066
Onchocerca volvulus 0.0029 0.0399 0.1
Brugia malayi chromobox protein homolog 3 0.0037 0.0541 0.0541
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0185 0.0476
Toxoplasma gondii facilitative glucose transporter GT1 0.0116 0.1959 0.3408
Trichomonas vaginalis hypothetical protein 0.0011 0.0075 0.0194
Loa Loa (eye worm) hypothetical protein 0.0019 0.0217 0.0217
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0609 0.0701
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0156 0.0402
Onchocerca volvulus 0.0016 0.0175 0.0422
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.0103
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0075 0.1452
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0591 0.1496
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0519 0.0597
Echinococcus granulosus Chromo domain 0.0011 0.0075 0.0195
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0022 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0126 0.0325
Echinococcus multilocularis ATP binding cassette sub family G 0.0009 0.0049 0.0127
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0156 0.0794
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0096 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0156 0.0402
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0075 0.0131
Echinococcus multilocularis nuclear receptor nhr 48 0.0007 0.0012 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0397 0.2025
Brugia malayi PAS domain containing protein 0.0046 0.0703 0.0703
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0277 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0134 0.0345
Trypanosoma brucei glucose transporter 2A 0.0036 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0156
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0506 0.2583
Onchocerca volvulus 0.0045 0.0696 0.1766
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0453
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0075 0.1452
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0156 0.0402
Loa Loa (eye worm) hypothetical protein 0.0012 0.0096 0.0096
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0347 0.0892
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0096 0.0248
Schistosoma mansoni hypothetical protein 0.0045 0.0696 0.3552
Brugia malayi Nuclear hormone receptor E75 0.0007 0.0012 0.0012
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0217 0.4291
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0506 0.0506
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0453
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0116 0.1959 0.5066
Echinococcus granulosus bloom syndrome protein 0.0019 0.0217 0.0561
Loa Loa (eye worm) hypothetical protein 0.0029 0.0399 0.0399
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0175 0.0451
Onchocerca volvulus 0.0027 0.0367 0.0918
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0105 0.1773 0.1773
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0156 0.0156
Echinococcus granulosus General substrate transporter 0.01 0.1668 0.4311
Leishmania major hypothetical protein, conserved 0.0105 0.1773 0.1773
Brugia malayi ecdysone receptor 0.0007 0.0012 0.0012
Plasmodium falciparum protein kinase 7 0.0328 0.5749 0.6612
Leishmania major C-8 sterol isomerase-like protein 0.0565 1 1
Brugia malayi MH2 domain containing protein 0.0008 0.002 0.002
Echinococcus granulosus ATP binding cassette sub family G 0.0009 0.0049 0.0127
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0027
Brugia malayi ecdysteroid receptor 0.0015 0.0156 0.0156
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0519 0.0597
Schistosoma mansoni nuclear receptor 0.0007 0.0012 0.006
Schistosoma mansoni chromobox protein 0.0066 0.1057 0.5395
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0175 0.8753
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0156 0.0156
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0075 0.0194
Brugia malayi ABC transporter family protein 0.0008 0.0024 0.0024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0519 0.1342
Schistosoma mansoni glucose transport protein 0.0116 0.1959 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0217 0.0561
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0175 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0519 0.1336
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0156
Brugia malayi hypoxia-induced factor 1 0.0142 0.242 0.242
Schistosoma mansoni aryl hydrocarbon receptor 0.0046 0.0703 0.3587
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Trichomonas vaginalis chromobox protein, putative 0.004 0.0591 0.1522
Entamoeba histolytica hypothetical protein 0.0011 0.0075 0.1452
Trypanosoma brucei glucose transporter, putative 0.0036 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Brugia malayi orphan nuclear receptor NR2E1 0.0007 0.0012 0.0012
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0022 0.0057
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.0103
Brugia malayi MH1 domain containing protein 0.0008 0.002 0.002
Trypanosoma brucei glucose transporter 1E 0.0036 0.0527 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0075 0.0194
Schistosoma mansoni glucose transport protein 0.0116 0.1959 1
Trichomonas vaginalis chromobox protein, putative 0.0066 0.1057 0.2721
Brugia malayi Protein cec-1. 0.0011 0.0075 0.0075
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0519 0.0597
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0156 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0156 0.0402
Schistosoma mansoni DNA helicase recq1 0.0019 0.0217 0.1108
Echinococcus multilocularis ATP binding cassette sub family G 0.0009 0.0049 0.0127
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0027
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0453
Brugia malayi MH1 domain containing protein 0.0008 0.002 0.002
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Brugia malayi MH2 domain containing protein 0.0112 0.1895 0.1895
Toxoplasma gondii protein kinase, putative 0.0328 0.5749 1
Schistosoma mansoni smad 0.0008 0.002 0.0103
Brugia malayi SET domain containing protein 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0047 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0075 0.0194
Onchocerca volvulus 0.0016 0.0175 0.0422
Brugia malayi major facilitator superfamily protein 0.0016 0.0175 0.0175
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0527 0.0527
Schistosoma mansoni protein kinase 0.0035 0.0519 0.2648
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0105 0.1773 0.1773
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0217 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0156 0.0156
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0489 0.1265
Schistosoma mansoni ABC transporter 0.0008 0.0024 0.0122
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.02 0.7229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0156 0.0156
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0347 0.0603
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0609 0.0609
Schistosoma mansoni ap endonuclease 0.0018 0.02 0.1021
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0519 0.1342
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Brugia malayi Cam kinase protein 1 0.0035 0.0519 0.0519
Loa Loa (eye worm) hypoxia-induced factor 1 0.0142 0.242 0.242
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0894
Loa Loa (eye worm) ABC transporter 0.0008 0.0024 0.0024
Trypanosoma cruzi Emopamil binding protein, putative 0.0105 0.1773 0.1773
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Onchocerca volvulus 0.0034 0.049 0.1234
Echinococcus multilocularis chromobox protein 1 0.0066 0.1057 0.2733
Onchocerca volvulus Bile acid receptor homolog 0.0015 0.0156 0.0372
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0217 0.0561
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0139 0.0139
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.02 0.023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0027 0.0139
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.002 0.0052
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.02 0.023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0156 0.0794
Entamoeba histolytica hypothetical protein 0.0034 0.0489 0.9431
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0096 0.0249
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0075
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0217 0.0378
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0105 0.1773 0.1773
Echinococcus granulosus Nuclear hormone receptor HR96 0.0007 0.0012 0.003
Mycobacterium leprae Possible regulatory protein 0.0012 0.0096 0.1901
Trypanosoma brucei glucose transporter, putative 0.0036 0.0527 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0156 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0527 0.1357
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.1959 0.5066
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0075 0.0075
Schistosoma mansoni cpg binding protein 0.0029 0.0395 0.2014
Loa Loa (eye worm) sugar transporter 0.0116 0.1959 0.1959
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0217 0.025
Brugia malayi major facilitator superfamily protein 0.0016 0.0175 0.0175
Loa Loa (eye worm) RecQ helicase 0.0019 0.0217 0.0217
Leishmania major glucose transporter, lmgt1 0.0036 0.0527 0.0527
Schistosoma mansoni survival motor neuron protein 0.0045 0.0696 0.3552
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0136 0.0136
Echinococcus granulosus cpg binding protein 0.0029 0.0395 0.102
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0156 0.0156
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0196 0.3401 0.3401
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0156 0.0794
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0609 0.0701
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0519 0.2648
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0075 0.0195
Echinococcus granulosus thyroid hormone receptor alpha 0.0007 0.0012 0.003
Onchocerca volvulus 0.0016 0.0175 0.0422
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0175 0.0451
Schistosoma mansoni protein kinase 0.0035 0.0519 0.2648
Onchocerca volvulus 0.0016 0.0175 0.0422
Schistosoma mansoni chromobox protein 0.0066 0.1057 0.5395
Schistosoma mansoni DNA helicase recq5 0.0019 0.0217 0.1108
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0519 0.1342
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0217 0.0561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0397 0.2025
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0096 0.0096
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0347 1
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0096 0.0248
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0053 0.0053
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.02 0.3856
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0527 0.1357
Brugia malayi hypothetical protein 0.0008 0.0027 0.0027
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0053 0.0273
Plasmodium vivax sugar transporter, putative 0.0016 0.0175 0.0201
Schistosoma mansoni chromobox protein 0.0011 0.0075 0.0384
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0156
Echinococcus multilocularis ATP binding cassette sub family G 0.0009 0.0049 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0009 0.0047 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0347 0.0896
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0007 0.0012 0.006
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Entamoeba histolytica recQ family helicase, putative 0.0009 0.0047 0.0904
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0136 0.0136
Onchocerca volvulus 0.0016 0.0175 0.0422
Brugia malayi CHD4 protein 0.0012 0.0103 0.0103
Echinococcus granulosus single minded 2 0.0034 0.049 0.1267
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0519 0.0903
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0156 0.0402
Onchocerca volvulus 0.0016 0.0175 0.0422
Toxoplasma gondii sugar transporter ST1 0.0016 0.0175 0.0305
Echinococcus multilocularis Smad4 0.0008 0.002 0.0052
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0008 0.0027 0.0027
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0053 0.0053
Schistosoma mansoni nuclear receptor 0.0007 0.0012 0.006
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Brugia malayi nuclear hormone receptor 0.0015 0.0156 0.0156
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0696 0.0696
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0075 0.0194
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0103 0.2107
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0609 0.0609
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0012 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Entamoeba histolytica ABC transporter, putative 0.0009 0.0049 0.0945
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0156 0.0794
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0096 0.0248
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0075 0.0075
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0156 0.0156
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0506 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0519 0.1342
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0075 0.0384
Brugia malayi conserved hypotetical protein 0.0007 0.0012 0.0012
Trichomonas vaginalis set domain proteins, putative 0.0223 0.3885 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0541 0.1393
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Plasmodium vivax CDK-related protein kinase 6, putative 0.0492 0.8696 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0397 0.0397
Loa Loa (eye worm) nuclear receptor NHR-67 0.0007 0.0012 0.0012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0367 0.0367
Leishmania major hypothetical protein, conserved 0.0016 0.0175 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0075 0.0194
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0894
Onchocerca volvulus 0.0012 0.0096 0.0218
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0175 0.6328
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0011 0.0075 0.0384
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0175 0.0175
Trypanosoma brucei glucose transporter, putative 0.0036 0.0527 0.0527
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0453
Schistosoma mansoni cpg binding protein 0.0027 0.0367 0.1874
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Onchocerca volvulus 0.0011 0.0075 0.0164
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0175 0.0453
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0009 0.0049 0.025
Plasmodium vivax hexose transporter 0.0116 0.1959 0.2253
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.02 0.02
Brugia malayi hypothetical protein 0.0007 0.0012 0.0012
Onchocerca volvulus 0.0015 0.0156 0.0372
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0175 0.3575
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0519 0.1342
Leishmania major protein kinase, putative 0.0035 0.0519 0.0519
Echinococcus granulosus nuclear receptor nhr 48 0.0007 0.0012 0.003
Echinococcus granulosus chromobox protein 1 0.0066 0.1057 0.2733
Plasmodium falciparum hexose transporter 0.0116 0.1959 0.2253
Echinococcus granulosus chromobox protein 2 0.0011 0.0075 0.0195
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0527 0.0527
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0156 0.0402
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0136 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0156 0.0156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.02 0.02
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.02 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0156 0.0794
Echinococcus multilocularis sodium channel protein 0.0045 0.0695 0.1796
Schistosoma mansoni hypothetical protein 0.0008 0.0022 0.0112
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0053 0.0061
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.002 0.0052
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0007 0.0012 0.0012
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0075 0.1452
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0057
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0565 1 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0075 0.0131
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0347 0.6849
Trypanosoma cruzi Emopamil binding protein, putative 0.0105 0.1773 0.1773
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0075 0.0131
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0217 0.0217
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0506 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0053
Leishmania major protein kinase, putative 0.0014 0.0136 0.0136
Entamoeba histolytica hypothetical protein 0.0034 0.0489 0.9431
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0453
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0045 0.0695 0.1796
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0096 0.0249
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0217 0.0559
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0096 0.0249
Onchocerca volvulus 0.0016 0.0175 0.0422
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0009 0.0049 0.0085
Brugia malayi Pre-SET motif family protein 0.0196 0.3401 0.3401
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0489 0.2498
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.02 0.0515
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0045 0.0695 0.0695
Schistosoma mansoni nuclear receptor nhr-48 0.0007 0.0012 0.006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0156 0.0156
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0519 0.0519
Schistosoma mansoni Smad4 0.0008 0.002 0.0103
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0156 0.0402
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0007 0.0012 0.003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0015 0.0156 0.0372
Loa Loa (eye worm) hypothetical protein 0.0035 0.0506 0.0506
Onchocerca volvulus 0.0016 0.0175 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0349 0.0899
Toxoplasma gondii sugar transporter ST2 0.0016 0.0175 0.0305
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.029 0.0745
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0156 0.0156
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0527 0.1357
Brugia malayi hypothetical protein 0.0011 0.0075 0.0075
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0217 0.0378
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0156 0.0402
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.02 0.0517
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0217 0.0217
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0133
Schistosoma mansoni glucose transporter 0.0016 0.0175 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0175 0.0451
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.1959 0.5066
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0075 0.0194
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0368 0.0951
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0156 0.0794
Loa Loa (eye worm) hypothetical protein 0.0565 1 1
Brugia malayi hypothetical protein 0.0034 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Brugia malayi hypothetical protein 0.0222 0.3868 0.3868
Onchocerca volvulus 0.0016 0.0175 0.0422
Trypanosoma cruzi hexose transporter, putative 0.002 0.0235 0.0235
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0185 0.0476
Entamoeba histolytica hypothetical protein 0.0034 0.0489 0.9431
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0347 0.0399
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0156 0.0402
Schistosoma mansoni single-minded 0.0046 0.0703 0.3587
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0075 0.0194
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0057
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0175 0.0175
Entamoeba histolytica protein kinase, putative 0.0035 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0156
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0277 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Plasmodium vivax SET domain protein, putative 0.0029 0.0397 0.0456
Loa Loa (eye worm) hypothetical protein 0.0029 0.0397 0.0397
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0519 0.1342
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0053 0.0093
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0175 0.3575
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0009 0.0049 0.0049
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0519 0.1342
Trypanosoma brucei Emopamil binding protein, putative 0.0105 0.1773 0.1773
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0156 0.0402
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0156 0.0156
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0008 0.0022 0.0792
Entamoeba histolytica hypothetical protein 0.0026 0.0347 0.6679
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0012 0.006
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.02 0.02
Brugia malayi MH2 domain containing protein 0.0008 0.002 0.002
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.048 0.124
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.005 0.005
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0506 0.0506
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0453
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0489 0.1265
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0075
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0075 0.0194
Trichomonas vaginalis chromobox protein, putative 0.004 0.0591 0.1522
Brugia malayi nuclear receptor RXR 0.0008 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0347 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0541 0.1393
Brugia malayi Nuclear hormone receptor E75 0.0007 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0035 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.0222 0.3868 0.3868
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0175 0.0453
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0103 0.0266
Trypanosoma brucei glucose transporter, putative 0.0036 0.0527 0.0527
Echinococcus multilocularis chromobox protein 2 0.0011 0.0075 0.0195
Echinococcus granulosus chromobox protein 1 0.0066 0.1057 0.2733
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0175 0.0175
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0175 0.0175
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0217 0.0559
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Echinococcus granulosus survival motor neuron protein 1 0.0222 0.3868 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.0819 0.1424
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0012 0.003
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0075 0.0194
Onchocerca volvulus Putative transporter 0.0016 0.0175 0.0422
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0519 0.0519
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0075 0.0194
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0008 0.0027 0.0139
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trypanosoma brucei glucose transporter, putative 0.0036 0.0527 0.0527
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0277 0.5469
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0075 0.0194
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0156 0.0156
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0187 0.3238 0.5632
Loa Loa (eye worm) hypothetical protein 0.0289 0.5054 0.5054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0928 0.4737
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0116 0.1959 0.5066
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Loa Loa (eye worm) hypothetical protein 0.0028 0.0389 0.0389
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0156 0.0156
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0156 0.0402
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0217 0.4184
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Echinococcus multilocularis survival motor neuron protein 1 0.0222 0.3868 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Echinococcus multilocularis Chromo domain 0.0011 0.0075 0.0195
Echinococcus multilocularis transfer RNA-Lys 0.0034 0.049 0.1267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0156 0.0156
Brugia malayi hypothetical protein 0.0008 0.0027 0.0027
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.02 0.3954
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0156 0.0402
Schistosoma mansoni ap endonuclease 0.0018 0.02 0.1021
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0347 0.7076
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0007 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Brugia malayi Sugar transporter family protein 0.0116 0.1959 0.1959
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0075 0.0194
Brugia malayi nuclear receptor NHR-88 0.0015 0.0156 0.0156
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0347 0.6849
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0175 0.0175
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0185 0.0476
Schistosoma mansoni hypothetical protein 0.0034 0.0489 0.2498
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0156 0.0156
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0009 0.0049 0.0049
Trypanosoma brucei sugar transporter, putative 0.0016 0.0175 0.0175
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0894
Brugia malayi hypothetical protein 0.0016 0.0175 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0039 0.0589 0.3005
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0103 0.5159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0096 0.0248
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0519 0.0903
Echinococcus granulosus smad 0.0008 0.002 0.0052
Trypanosoma cruzi ABC transporter, putative 0.0009 0.0049 0.0049
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0103 0.0525
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0527 0.0527
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0609 0.0609
Entamoeba histolytica hypothetical protein 0.0034 0.0489 0.9431
Onchocerca volvulus 0.0016 0.0175 0.0422
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0009 0.0049 0.1002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0185 0.0476
Trypanosoma brucei glucose transporter, putative 0.0036 0.0527 0.0527
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0075 0.0075
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0217 0.0561
Loa Loa (eye worm) hypothetical protein 0.0154 0.2633 0.2633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0185 0.0476
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0187 0.3238 0.3724
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.0103
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0007 0.0012 0.003
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0527 0.1357
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0519 0.0903
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0894
Trypanosoma brucei ATP-binding cassette protein, putative 0.0009 0.0049 0.0049
Loa Loa (eye worm) sugar transporter 0.0016 0.0175 0.0175
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0347 0.0399
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0527 0.0527
Schistosoma mansoni protein kinase 0.0035 0.0519 0.2648
Brugia malayi tailless protein 0.0007 0.0012 0.0012
Schistosoma mansoni coup transcription factor 0.0015 0.0156 0.0794
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0075 0.0087
Loa Loa (eye worm) transcription factor SMAD2 0.0112 0.1895 0.1895
Brugia malayi nuclear hormone receptor 0.0007 0.0012 0.0012
Echinococcus multilocularis General substrate transporter 0.01 0.1668 0.4311
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0519 0.0597
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.048 0.124
Entamoeba histolytica hypothetical protein 0.0011 0.0075 0.1452
Echinococcus granulosus Smad4 0.0008 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0053
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0103 0.0266
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0185 0.0476
Brugia malayi hypothetical protein 0.0016 0.0175 0.0175
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0347 0.1769
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0156 0.0156
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0156 0.0794
Trypanosoma brucei glucose transporter, putative 0.0036 0.0527 0.0527
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0217 0.025
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0217 0.0217
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0175 0.3575
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Giardia lamblia ABC transporter 0.0009 0.0047 0.0931
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.02 0.02
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0075 0.0087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0156 0.0402
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0347 0.7076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.02 0.02
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0397 0.069
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0527 0.1357
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0075
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0156 0.0402
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0075 0.0195
Onchocerca volvulus 0.0016 0.0175 0.0422
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.02 0.0517
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0156 0.0794
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0397 0.1026
Trichomonas vaginalis chromobox protein, putative 0.0066 0.1057 0.2721
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Leishmania major glucose transporter, lmgt3 0.0036 0.0527 0.0527
Brugia malayi nuclear hormone receptor family member nhr-6 0.0007 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0035 0.0519 0.0519
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0347 0.0896
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0156 0.0794
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0397 0.1026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0609 0.106
Brugia malayi nuclear receptor NHR-88 0.0007 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0096 0.0248
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0217 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0075 0.0194
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0075 0.0384
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0075 0.0384
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0012
Onchocerca volvulus 0.0016 0.0175 0.0422
Onchocerca volvulus 0.0016 0.0175 0.0422
Loa Loa (eye worm) MH2 domain-containing protein 0.0112 0.1895 0.1895
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0175 0.0175
Loa Loa (eye worm) helicase 0.0011 0.0075 0.0075
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0096 0.0096
Entamoeba histolytica hypothetical protein 0.0011 0.0075 0.1452
Loa Loa (eye worm) DR-78 0.0007 0.0012 0.0012
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0156
Leishmania major protein kinase, putative 0.0014 0.0136 0.0136
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0175 0.0453
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0175 0.0451
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0156
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0075 0.0075
Toxoplasma gondii sugar transporter ST3 0.0016 0.0175 0.0305
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0156
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0519 0.0597
Trypanosoma cruzi hexose transporter 0.0036 0.0527 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0527 0.1357
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0519 0.0597
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0506 0.9752
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0519 0.0597
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0096 0.0249
Brugia malayi nuclear receptor NHR-67 0.0007 0.0012 0.0012
Onchocerca volvulus 0.0016 0.0175 0.0422
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0053 0.2669
Leishmania major glucose transporter, lmgt2 0.0036 0.0527 0.0527
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0075 0.0194
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0175

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1300 nM BindingDB_Patents: FLIPR Assay. Recombinant Nav1.7 Cell Line: In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Accession No. NM__002977). The cell line was provided by investigators at Yale University (Cummins et al, J. Neurosci. 18(23): 9607-9619 (1998)). For dominant selection of the Nav1.7-expressing clones, the expression plasmid co-expressed the neomycin resistance gene. The cell line was constructed in the human embryonic kidney cell line, HEK293, under the influence of the CMV major late promoter, and stable clones were selected using limiting dilution cloning and antibiotic selection using the neomycin analogue, G418. Recombinant beta and gamma subunits were not introduced into this cell line. Additional cell lines expressing recombinant Nav1.7 cloned from other species can also be used, alone or in combination with various beta subunits, gamma subunits or chaperones.Non-Recombinant Cell Lines Expressing Native Nav1. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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