Detailed information for compound 19908

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.761 | Formula: C18H14ClNO4
  • H donors: 1 H acceptors: 3 LogP: 3.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO/C(=C/1\C(=O)N(Cc2ccccc2)C(=O)c2c1cc(Cl)cc2)/O
  • InChi: 1S/C18H14ClNO4/c1-24-18(23)15-14-9-12(19)7-8-13(14)16(21)20(17(15)22)10-11-5-3-2-4-6-11/h2-9,23H,10H2,1H3/b18-15-
  • InChiKey: CZFHDLVYKFRMAC-SDXDJHTJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0047 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0239 0.0433
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0047 0.0047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0882 0.398 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0047 0.0047
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0367 0.2816
Echinococcus multilocularis transcription factor btf3 0.0146 0.0612 0.0612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0043 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0043 0.0107
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0005 0.0009
Echinococcus granulosus chromobox protein 1 0.0013 0.0005 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0043 0.0043
Plasmodium vivax thioredoxin reductase, putative 0.0129 0.0536 0.8747
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0005 0.0009
Trypanosoma brucei polo-like protein kinase 0.0093 0.0367 0.2816
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0072 0.0072
Loa Loa (eye worm) RecQ helicase 0.0047 0.0158 0.0397
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0239 0.0433
Echinococcus multilocularis mitogen activated protein kinase 3 0.0106 0.0429 0.0429
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0528 0.0528
Brugia malayi jmjC domain containing protein 0.0018 0.0028 0.007
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.022 0.0552
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0045 0.0149 0.0149
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0016
Loa Loa (eye worm) glutaminase 0.0321 0.141 0.3543
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0016
Trichomonas vaginalis DNA helicase recq, putative 0.0047 0.0158 0.0286
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.022 0.1686
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0047 0.0117
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0047 0.0047
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0029 0.048
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0005 0.008
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0117
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0135 0.1035
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0172 0.0312
Loa Loa (eye worm) thioredoxin reductase 0.0129 0.0536 0.1345
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0156 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0029 0.0225
Treponema pallidum fructose-bisphosphate aldolase 0.1219 0.5519 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0043 0.0043
Schistosoma mansoni chromobox protein 0.0013 0.0005 0.0005
Echinococcus multilocularis pyruvate kinase 0.0033 0.0094 0.0094
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0153 0.0278
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0149 0.0149
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0029 0.0225
Loa Loa (eye worm) hypothetical protein 0.006 0.022 0.0552
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.0298 0.0748
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0043 0.0043
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.001 0.001
Leishmania major pyruvate kinase 0.0033 0.0094 0.0721
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0107
Entamoeba histolytica hypothetical protein 0.0013 0.0005 0.0009
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0086 0.0662
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0028 0.0028
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.001 0.0019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0128 0.0528 0.8626
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0043 0.0107
Plasmodium falciparum thioredoxin reductase 0.0129 0.0536 0.8747
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0043 0.0043
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.022 0.1686
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0295 0.1294 0.485
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0086 0.0323
Loa Loa (eye worm) 6-phosphofructokinase 0.0239 0.1036 0.2602
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.001 0.0026
Brugia malayi CXXC zinc finger family protein 0.0063 0.0232 0.0583
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0528 0.0528
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0134 0.1029
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0086 0.0217
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0012
Entamoeba histolytica hypothetical protein 0.0022 0.0047 0.0084
Onchocerca volvulus 0.0063 0.0232 0.0512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0043 0.0107
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0043 0.0043
Brugia malayi phosphofructokinase 0.0239 0.1036 0.2602
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0149 0.1141
Loa Loa (eye worm) hypothetical protein 0.0088 0.0344 0.0865
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0029 0.048
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0064 0.0239 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Brugia malayi Pre-SET motif family protein 0.0128 0.0528 0.1327
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0043 0.0043
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0094 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0032 0.0058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0043 0.0107
Echinococcus multilocularis chromobox protein 2 0.0013 0.0005 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0183 0.078 0.2923
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0064 0.0239 0.0355
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0122 0.0501 0.0501
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0056 0.0211
Echinococcus multilocularis pyruvate kinase 0.0017 0.0021 0.0021
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0005 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Schistosoma mansoni cpg binding protein 0.0067 0.0249 0.0249
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0029 0.0029
Brugia malayi CHD4 protein 0.0017 0.0021 0.0054
Schistosoma mansoni pyruvate kinase 0.0017 0.0021 0.0021
Echinococcus multilocularis dnaJ subfamily B 0.048 0.2138 0.2138
Schistosoma mansoni chromobox protein 0.0013 0.0005 0.0005
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0239 0.1036 0.3883
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0087 0.0218
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0043 0.0107
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0032 0.0089 0.1448
Brugia malayi glutathione reductase 0.0129 0.0536 0.1345
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Echinococcus granulosus chromobox protein 1 0.0013 0.0005 0.0005
Echinococcus multilocularis pyruvate kinase 0.0017 0.0021 0.0021
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0052 0.0131
Echinococcus granulosus Chromobox protein 3 0.0013 0.0005 0.0005
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0032 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0043 0.0043
Trichomonas vaginalis glutathione reductase, putative 0.0045 0.0149 0.027
Giardia lamblia DINP protein human, muc B family 0.006 0.022 0.0398
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0094 0.0721
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0064 0.0239 0.0433
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.007 0.0127
Brugia malayi MAP kinase sur-1 0.0106 0.0429 0.1078
Loa Loa (eye worm) hypothetical protein 0.0119 0.0487 0.1223
Echinococcus granulosus pyruvate kinase 0.0017 0.0021 0.0021
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0367 0.0367
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.021 0.0529
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0094 0.0721
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0259 0.0259
Trypanosoma brucei unspecified product 0.0042 0.0134 0.1029
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0065 0.05
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0094 0.0352
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0047 0.0047
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0064 0.0239 0.0433
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0094 0.1534
Echinococcus multilocularis bloom syndrome protein 0.0047 0.0158 0.0158
Leishmania major DNA polymerase eta, putative 0.0019 0.0029 0.0225
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0183 0.078 0.078
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0134 0.1029
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0554 0.0554
Schistosoma mansoni glutaminase 0.0321 0.141 0.141
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0239 0.1036 0.3883
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Brugia malayi hypothetical protein 0.0017 0.0022 0.0056
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0047 0.0117
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0554 0.4247
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0015 0.001 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0141 0.0589 0.0589
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0298 0.2284
Entamoeba histolytica transcription factor BTF3, putative 0.0146 0.0612 0.1109
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0045 0.0081
Loa Loa (eye worm) glutaminase 2 0.0321 0.141 0.3543
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0045 0.0149 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0134 0.1029
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0032 0.0032
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.022 0.0398
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0276 0.0693
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.022 0.1686
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0065 0.1064
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.0721 0.1812
Trypanosoma brucei DNA polymerase eta, putative 0.006 0.022 0.1686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0043 0.0107
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0005 0.0012
Echinococcus multilocularis cpg binding protein 0.0067 0.0249 0.0249
Trichomonas vaginalis phosphofructokinase, putative 0.0239 0.1036 0.1876
Schistosoma mansoni lamin 0.0058 0.021 0.021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.007 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0043 0.0107
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0005 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0149 0.1141
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.001 0.0168
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.004 0.0072
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.0149 0.1141
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0047 0.0117
Echinococcus granulosus lamin dm0 0.0058 0.021 0.021
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0045 0.0149 0.1141
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.0149 0.1141
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0028 0.0214
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0107
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0033 0.0094 0.0237
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0005 0.0009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0032 0.0526
Brugia malayi beta-NAC-like protein 0.0146 0.0612 0.1538
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0005 0.008
Entamoeba histolytica hypothetical protein 0.0146 0.0612 0.1109
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0367 0.0367
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0094 0.0721
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0172 0.0312
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0028 0.0028
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0094 0.0352
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0554 0.2076
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0047 0.0047
Schistosoma mansoni DNA helicase recq1 0.0019 0.0032 0.0032
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0005 0.008
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0047 0.0047
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0476 0.0476
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0531 0.8666
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0033 0.0094 0.0237
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0117
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.022 0.0552
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0047 0.0047
Schistosoma mansoni DNA helicase recq5 0.0019 0.0032 0.0032
Echinococcus multilocularis expressed protein 0.0438 0.1946 0.1946
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0005 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0016
Plasmodium falciparum pyruvate kinase 0.0033 0.0094 0.1534
Mycobacterium tuberculosis Probable oxidoreductase 0.0328 0.1444 0.5415
Loa Loa (eye worm) hypothetical protein 0.0119 0.0487 0.1223
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0028 0.0028
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0032 0.0526
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0476 0.0476
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0065 0.1064
Brugia malayi polk-prov protein 0.0019 0.0029 0.0074
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0105 0.0426 0.0426
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0172 0.2815
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0106 0.0429 0.3291
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0045 0.0342
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0064 0.0239 0.3899
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0587 0.4505
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0135 0.1035
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0047 0.0047
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0172 0.2815
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0047 0.0047
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0094 0.0236
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0367 0.0665
Echinococcus multilocularis lamin 0.0058 0.021 0.021
Brugia malayi jmjC domain containing protein 0.0069 0.0259 0.0651
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0043 0.0043
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0045 0.0081
Loa Loa (eye worm) histone methyltransferase 0.0024 0.0054 0.0136
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0043 0.0043
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0056 0.0921
Echinococcus granulosus bloom syndrome protein 0.0047 0.0158 0.0158
Echinococcus multilocularis lamin dm0 0.0058 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0107
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0105 0.0426 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0047 0.0084
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0012
Toxoplasma gondii NAC domain-containing protein 0.0146 0.0612 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0012
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.006 0.022 0.0552
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0005 0.0009
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.001 0.0168
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.0721 0.0721
Brugia malayi PXA domain containing protein 0.0022 0.0047 0.0117
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0045 0.0728
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0172 0.0172
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0028 0.0455
Brugia malayi Protein cec-1. 0.0013 0.0005 0.0012
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.1304 1
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0005 0.0009
Schistosoma mansoni cpg binding protein 0.0063 0.0232 0.0232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0043 0.0043
Brugia malayi Cytochrome P450 family protein 0.0031 0.0086 0.0217
Leishmania major trypanothione reductase 0.0129 0.0536 0.4108
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.022 0.1686
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0053 0.0133
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0047 0.0047
Brugia malayi M-phase phosphoprotein, mpp8 0.0119 0.0487 0.1223
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0344 0.0344
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0295 0.1294 0.485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0043 0.0107
Echinococcus multilocularis thioredoxin glutathione reductase 0.013 0.054 0.054
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0045 0.0149 0.243
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0554 0.2076
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0105 0.0426 0.0426
Schistosoma mansoni chromobox protein 0.0013 0.0005 0.0005
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0135 0.1035
Brugia malayi hypothetical protein 0.0022 0.0047 0.0117
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.007
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0047 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0043 0.0043
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0367 0.2816
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0021 0.0021
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0064 0.0239 0.3899
Toxoplasma gondii thioredoxin reductase 0.0129 0.0536 0.8747
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0054 0.0054
Echinococcus granulosus transcription factor btf3 0.0146 0.0612 0.0612
Toxoplasma gondii phosphofructokinase PFKII 0.0064 0.0239 0.3899
Loa Loa (eye worm) glutathione reductase 0.0129 0.0536 0.1345
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0058 0.0447
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0043 0.0043
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0029 0.0225
Schistosoma mansoni jumonji domain containing protein 0.0069 0.0259 0.0259
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0367 0.0665
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0107
Plasmodium vivax basic transcription factor 3b, putative 0.0146 0.0612 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0106 0.0429 0.3291
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0094 0.0236
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0367 0.0367
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0056 0.0921
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.001 0.0079
Entamoeba histolytica hypothetical protein 0.0022 0.0047 0.0084
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.001 0.0019
Leishmania major DNA damage repair protein, putative 0.0019 0.0029 0.0225
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0045 0.0149 0.1141
Entamoeba histolytica hypothetical protein 0.0022 0.0047 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0149 0.1141
Echinococcus multilocularis mitogen activated protein kinase 0.0106 0.0429 0.0429
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0429 0.3291
Schistosoma mansoni intermediate filament proteins 0.0058 0.021 0.021
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0005 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0045 0.0112
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0043 0.0043
Trichomonas vaginalis mercuric reductase, putative 0.0045 0.0149 0.027
Plasmodium falciparum thioredoxin reductase 0.0045 0.0149 0.243
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0087 0.0218
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0005 0.0009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0595 0.2667 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0052 0.0131
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0094 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0043 0.0107
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0106 0.0429 0.3291
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0013 0.0005 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0043 0.0107
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0028 0.0028
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0005 0.0009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0072 0.0072
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0056 0.0432
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0276 0.0276
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0065 0.05
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0037 0.0115 0.0288
Brugia malayi jmjC domain containing protein 0.0018 0.0028 0.007
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0021 0.034
Trypanosoma cruzi trypanothione reductase, putative 0.0129 0.0536 0.4108
Trichomonas vaginalis phosphofructokinase, putative 0.0239 0.1036 0.1876
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.007 0.0127
Schistosoma mansoni cpg binding protein 0.0067 0.0249 0.0249
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0028 0.007
Mycobacterium ulcerans hypothetical protein 0.0157 0.066 0.2475
Echinococcus granulosus cpg binding protein 0.0067 0.0249 0.0249
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.0037 0.0037
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0047 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0367 0.0665
Brugia malayi jmjC domain containing protein 0.0073 0.0276 0.0693
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0177 0.1356
Echinococcus granulosus pyruvate kinase 0.0033 0.0094 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0595 0.2667 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0045 0.0149 0.1141
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0429 0.0777
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0032 0.0081
Schistosoma mansoni 6-phosphofructokinase 0.0239 0.1036 0.1036
Brugia malayi 6-phosphofructokinase 0.0239 0.1036 0.2602
Echinococcus granulosus mitogen activated protein kinase 3 0.0106 0.0429 0.0429
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0045 0.0149 0.243
Echinococcus multilocularis pyruvate kinase 0.0017 0.0021 0.0021
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0043 0.0043
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0032 0.0081
Onchocerca volvulus 0.0141 0.0589 0.1299
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0029 0.0225
Loa Loa (eye worm) ICD-1 protein 0.0146 0.0612 0.1538
Schistosoma mansoni coup transcription factor 0.0022 0.0043 0.0043
Brugia malayi Thioredoxin reductase 0.0129 0.0536 0.1345
Echinococcus granulosus dna polymerase eta 0.006 0.022 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0016
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0005 0.008
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0056 0.0921
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0043 0.0107
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0094 0.0207
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0029 0.0225
Trypanosoma brucei trypanothione reductase 0.0129 0.0536 0.4108
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0056 0.3788
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0081
Loa Loa (eye worm) 6-phosphofructokinase 0.0239 0.1036 0.2602
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Leishmania major DNA polymerase kappa, putative 0.0019 0.0029 0.0225
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0116 0.0476 0.0476
Brugia malayi 6-phosphofructokinase 0.0239 0.1036 0.2602
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0058 0.0106
Echinococcus granulosus dna polymerase kappa 0.006 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0037 0.0037
Loa Loa (eye worm) helicase 0.0013 0.0005 0.0012
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0032 0.0032
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0043 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0429 0.0777
Giardia lamblia Kinase, PLK 0.0093 0.0367 0.0665
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0094 0.017
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.001 0.0168
Echinococcus multilocularis geminin 0.0168 0.0711 0.0711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0043 0.0107
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.0298 0.0748
Entamoeba histolytica hypothetical protein 0.0013 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.021 0.0529
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0117
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.0037 0.0037
Giardia lamblia Fructose-bisphosphate aldolase 0.1219 0.5519 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0047 0.0158 0.0286
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0047 0.0047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0043 0.0043
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0032 0.0032
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0106 0.0429 0.1078
Entamoeba histolytica deoxycytidyl transferase, putative 0.006 0.022 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0047 0.0084
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0052 0.0052
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0047 0.0047
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0025 0.0056 0.0102
Loa Loa (eye worm) hypothetical protein 0.0128 0.0528 0.1327
Echinococcus multilocularis pyruvate kinase 0.0033 0.0094 0.0094
Onchocerca volvulus 0.0058 0.021 0.0464
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1219 0.5519 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0016
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0239 0.1036 0.7944
Brugia malayi SET domain containing protein 0.0019 0.0032 0.0082
Trypanosoma cruzi transcription factor btf3, putative 0.0146 0.0612 0.4696
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0367 0.0665
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0149 0.0149
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.007 0.0127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.007 0.0127
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0087 0.142
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.0113 0.0113
Loa Loa (eye worm) intermediate filament protein 0.0058 0.021 0.0529
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0015 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0182
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0045 0.2997
Brugia malayi hypothetical protein 0.0027 0.0065 0.0164
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0005 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.007 0.0127
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0052 0.0052
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0043 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0047 0.0084
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0094 0.1534
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.066 0.2475
Schistosoma mansoni hypothetical protein 0.0168 0.0711 0.0711
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0043 0.0043
Echinococcus multilocularis chromobox protein 1 0.0013 0.0005 0.0005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0132 0.2157
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.001 0.001
Echinococcus granulosus intermediate filament protein 0.0058 0.021 0.021
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0344 0.0344
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0153 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.0298 0.0298
Brugia malayi glutaminase DH11.1 0.0321 0.141 0.3543
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0295 0.1294 0.485
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0232 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Leishmania major ATP-dependent phosphofructokinase 0.0239 0.1036 0.7944
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0367 0.0665
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1219 0.5519 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0328 0.1444 0.5415
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0047 0.0047
Mycobacterium ulcerans DNA polymerase IV 0.006 0.022 0.0824
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0028 0.007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0149 0.1141
Echinococcus granulosus 6 phosphofructokinase 0.0239 0.1036 0.1036
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0056 0.0432
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0149 0.1141
Echinococcus multilocularis dna polymerase kappa 0.006 0.022 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.0612 0.1109
Plasmodium falciparum basic transcription factor 3b, putative 0.0146 0.0612 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0595 0.2667 1
Schistosoma mansoni DNA polymerase eta 0.006 0.022 0.022
Loa Loa (eye worm) phosphofructokinase 0.0239 0.1036 0.2602
Leishmania major cytochrome p450-like protein 0.0031 0.0086 0.0662
Echinococcus granulosus dnaJ subfamily B 0.048 0.2138 0.2138
Trypanosoma brucei protein kinase, putative 0.0106 0.0429 0.3291
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0047 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0035 0.0064
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0043 0.0043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0149 0.1141
Brugia malayi Bloom's syndrome protein homolog 0.0047 0.0158 0.0397
Mycobacterium ulcerans DNA polymerase IV 0.006 0.022 0.0824
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0094 0.0721
Brugia malayi nuclear receptor NHR-88 0.0022 0.0043 0.0107
Echinococcus multilocularis 0.0015 0.001 0.001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0047 0.0047
Brugia malayi Heterochromatin protein 1 0.0013 0.0005 0.0012
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0029 0.048
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0554 0.0554
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0013 0.0005 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1219 0.5519 1
Onchocerca volvulus 0.0022 0.0043 0.0094
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0065 0.05
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0086 0.0662
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.0298 0.0298
Echinococcus multilocularis Chromo domain 0.0013 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1219 0.5519 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0058 0.0447
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0028 0.007
Leishmania major pyruvate kinase 0.0033 0.0094 0.0721
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0328 0.1444 0.5415
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0044 0.0044
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0094 0.0236
Schistosoma mansoni ap endonuclease 0.0022 0.0045 0.0045
Echinococcus granulosus Chromo domain 0.0013 0.0005 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0045 0.0149 0.243
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0587 0.4505
Loa Loa (eye worm) hypothetical protein 0.0058 0.021 0.0529
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0239 0.1036 0.181
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0047 0.0084
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0094 0.0352
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0045 0.0045
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0021 0.0021
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0047 0.0117
Loa Loa (eye worm) hypothetical protein 0.0372 0.1645 0.4134
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0239 0.0433
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0045 0.0149 0.0558
Giardia lamblia Pyruvate kinase 0.0017 0.0021 0.0038
Mycobacterium tuberculosis Probable reductase 0.0295 0.1294 0.485
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0021 0.034
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0028 0.0455
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0021 0.034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0117
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0094 0.0207
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0045 0.0342
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0065 0.1064
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0029 0.048
Brugia malayi intermediate filament protein 0.0058 0.021 0.0529
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0367 0.0665
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0058 0.0447
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0024
Loa Loa (eye worm) heterochromatin protein 1 0.0013 0.0005 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0528 0.0528
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0043 0.0043
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0029 0.048
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.0298 0.2284
Loa Loa (eye worm) acetyltransferase 0.017 0.0721 0.1812
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.007 0.0127
Chlamydia trachomatis pyruvate kinase 0.0033 0.0094 0.206
Onchocerca volvulus 0.0119 0.0487 0.1073
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0045 0.0149 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0367 0.0665
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0107
Trichomonas vaginalis dullard protein, putative 0.0015 0.001 0.0019
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0107
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0052 0.0052
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0367 0.0922
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0056 0.0211
Echinococcus granulosus pyruvate kinase 0.0017 0.0021 0.0021
Onchocerca volvulus 0.1004 0.4537 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0032 0.0526
Schistosoma mansoni hypothetical protein 0.048 0.2138 0.2138
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0029 0.0225
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0239 0.1036 0.7944
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.022 0.0824
Schistosoma mansoni terminal deoxycytidyl transferase 0.006 0.022 0.022
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0047 0.0117
Schistosoma mansoni hypothetical protein 0.0013 0.0005 0.0005
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0135 0.1035
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0052 0.0131
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0005 0.0005
Brugia malayi nuclear hormone receptor 0.0022 0.0043 0.0107
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0047 0.0117
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0043 0.0043
Plasmodium vivax SET domain protein, putative 0.0128 0.0528 0.8626
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0106 0.0429 0.3291
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Brugia malayi hypothetical protein 0.0119 0.0487 0.1223
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0045 0.0342
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0106 0.0429 0.7008
Leishmania major hypothetical protein, conserved 0.0018 0.0028 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0043 0.0107
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0298 0.2284
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0276 0.0276
Echinococcus granulosus pyruvate kinase 0.0017 0.0021 0.0021
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.022 0.0824
Giardia lamblia DNA damage repair protein 0.0019 0.0029 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0043 0.0107
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.001 0.0019
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0554 0.0554
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0029 0.0225
Onchocerca volvulus 0.0058 0.021 0.0464
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0587 0.4505
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0043 0.0094
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0043 0.0043
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0064 0.0239 1
Leishmania major basic transcription factor 3a, putative 0.0146 0.0612 0.4696
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0047 0.0047
Brugia malayi jmjC domain containing protein 0.0018 0.0028 0.007
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0183 0.078 0.1959
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0429 0.0777
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.007
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.001 0.001
Schistosoma mansoni 6-phosphofructokinase 0.0239 0.1036 0.1036
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0153 0.2504
Echinococcus granulosus chromobox protein 2 0.0013 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0061 0.0221 0.0221
Schistosoma mansoni kinase 0.0048 0.0161 0.0161
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1219 0.5519 1
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0571 0.2554 0.4628
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0183 0.078 0.5981
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0005 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Trichomonas vaginalis phosphofructokinase, putative 0.0239 0.1036 0.1876
Echinococcus granulosus lamin 0.0058 0.021 0.021
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0367 0.0922
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.0149 1
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.007
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.1304 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0183 0.078 0.078
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0028 0.0214
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0106 0.0429 0.3291
Schistosoma mansoni pyruvate kinase 0.0033 0.0094 0.0094
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.0721 0.0721
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0128 0.0528 0.0528
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Toxoplasma gondii 6-phosphofructokinase 0.0064 0.0239 0.3899
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.001 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0138 0.0577 0.0577
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0045 0.0112
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0116 0.0476 0.1196
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0047 0.0117
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0086 0.0217
Trichomonas vaginalis phosphofructokinase, putative 0.0239 0.1036 0.1876
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0129 0.0536 0.2008
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0005 0.008
Entamoeba histolytica phosphofructokinase, putative 0.0239 0.1036 0.1876
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0122
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.006 0.022 0.022
Onchocerca volvulus 0.0119 0.0487 0.1073
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0005 0.0009
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0476 0.0476
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.0149 0.1141
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0048 0.0122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0043 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0043 0.0043
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0101 0.0253
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0045 0.0149 0.0558
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Echinococcus granulosus pyruvate kinase 0.0033 0.0094 0.0094
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0043 0.0043
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0045 0.0149 0.0558
Trichomonas vaginalis hypothetical protein 0.0013 0.0005 0.0009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0045 0.0728
Trypanosoma brucei unspecified product 0.0042 0.0134 0.1029
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.0298 0.0298
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0028 0.0214
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0029 0.0225
Brugia malayi PXA domain containing protein 0.0022 0.0047 0.0117
Leishmania major hypothetical protein, conserved 0.0027 0.0065 0.05
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0005 0.008
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0064 0.0239 0.3899
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1219 0.5519 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0183 0.078 0.2923
Schistosoma mansoni pyruvate kinase 0.0033 0.0094 0.0094
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0047 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0005 0.0005
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0032 0.0081
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0021 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1219 0.5519 1
Plasmodium vivax glutathione reductase, putative 0.0129 0.0536 0.8747
Brugia malayi steroid hormone receptor 0.0022 0.0043 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.008
Echinococcus granulosus thioredoxin glutathione reductase 0.013 0.054 0.054
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0086 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0009
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0005 0.0005
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0344 0.0865
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0117
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0259 0.0259
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0028 0.0455
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.006 0.022 0.022
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0105 0.0426 0.0426
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0056 0.0211
Leishmania major hypothetical protein, conserved 0.0015 0.001 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0016
Onchocerca volvulus 0.0088 0.0344 0.0759
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1219 0.5519 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0029 0.0225
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0239 0.0433
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.022 0.1686
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0043 0.0107
Echinococcus granulosus expressed protein 0.0438 0.1946 0.1946
Brugia malayi hypothetical protein 0.0022 0.0047 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0052 0.0052
Echinococcus multilocularis microtubule associated protein 2 0.2199 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0045 0.0081
Giardia lamblia NADH oxidase lateral transfer candidate 0.0045 0.0149 0.027
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0028 0.0028
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0045 0.0081
Brugia malayi Cytochrome P450 family protein 0.0034 0.0101 0.0253
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0429 0.0777
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.017
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0183 0.078 0.078
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.001 0.001
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0005 0.0009
Plasmodium falciparum glutathione reductase 0.0045 0.0149 0.243
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0295 0.1294 0.485
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0043 0.0043
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0043 0.0094
Plasmodium vivax 6-phosphofructokinase, putative 0.0064 0.0239 0.3899
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.022 0.1686
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.0612 0.1109
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0571 0.2554 0.4628
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0058 0.0106
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0043 0.0043
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0298 0.2284
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0028 0.0028
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0045 0.0149 0.243
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0128 0.0528 0.0528
Treponema pallidum NADH oxidase 0.0045 0.0149 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.022 0.1686
Trichomonas vaginalis dullard protein, putative 0.0015 0.001 0.0019
Echinococcus multilocularis chromobox protein 1 0.0013 0.0005 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0086 0.0662
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.017 0.0723 0.1817
Trichomonas vaginalis set domain proteins, putative 0.1004 0.4537 0.8221
Schistosoma mansoni chromobox protein 0.0013 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1219 0.5519 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0047 0.0047
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.0699 0.0699
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0043 0.0043
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0005 0.0009
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0183 0.078 0.2923
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0116 0.0476 0.1196
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0047 0.0117
Mycobacterium ulcerans hypothetical protein 0.0019 0.0029 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0554 0.2076
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.001 0.0079
Leishmania major DNA polymerase kappa, putative 0.006 0.022 0.1686
Echinococcus granulosus mitogen activated protein kinase 0.0106 0.0429 0.0429
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0056 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0276 0.0276
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0367 0.0665
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.006 0.022 0.022
Trichomonas vaginalis glutaminase, putative 0.0321 0.141 0.2555
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0045 0.0149 0.243
Plasmodium falciparum glutathione reductase 0.0129 0.0536 0.8747
Mycobacterium ulcerans glutaminase 0.0321 0.141 0.5287
Trypanosoma brucei transcription factor BTF3, putative 0.0146 0.0612 0.4696
Loa Loa (eye worm) hypothetical protein 0.0057 0.0206 0.0517
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0005 0.0005
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0259 0.0259
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0476 0.0476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.007 0.0127
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0045 0.0149 0.0149
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0043 0.0043
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0429 0.3291
Brugia malayi hypothetical protein 0.0143 0.0597 0.1499
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1304 1
Echinococcus multilocularis 6 phosphofructokinase 0.0239 0.1036 0.1036
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.0128 0.0528 0.0528
Trypanosoma brucei unspecified product 0.006 0.022 0.1686
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0029 0.0225
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0367 0.2816
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0064 0.0239 0.0433
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0026
Trichomonas vaginalis dullard protein, putative 0.0015 0.001 0.0019
Entamoeba histolytica phosphofructokinase, putative 0.0239 0.1036 0.1876
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0065 0.1064
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0239 0.0433
Brugia malayi Pre-SET motif family protein 0.0882 0.398 1
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.0612 0.1109
Schistosoma mansoni hypothetical protein 0.0014 0.0009 0.0009
Mycobacterium tuberculosis Probable dehydrogenase 0.0295 0.1294 0.485
Plasmodium vivax 6-phosphofructokinase, putative 0.0064 0.0239 0.3899
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0028 0.0028
Brugia malayi jmjC domain containing protein 0.0018 0.0028 0.007
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0048 0.0088
Echinococcus granulosus Solute carrier family 22 5 0.1025 0.463 0.463
Brugia malayi Cytochrome P450 family protein 0.0031 0.0086 0.0217
Trypanosoma cruzi transcription factor btf3, putative 0.0146 0.0612 0.4696
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0005 0.0009
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0047 0.0084
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0554 0.9043
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.0149 1
Toxoplasma gondii hypothetical protein 0.0048 0.0163 0.2663
Plasmodium vivax JmjC domain containing protein 0.0018 0.0028 0.0455
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0047 0.0047
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.022 0.0398
Schistosoma mansoni lamin 0.0058 0.021 0.021
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.022 0.1686
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0239 0.0433
Schistosoma mansoni microtubule-associated protein tau 0.2199 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0045 0.0045
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0045 0.0149 0.1141
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0295 0.1294 0.485
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0094 0.0236
Echinococcus multilocularis pyruvate kinase 0.0026 0.0062 0.0062
Mycobacterium ulcerans 6-phosphofructokinase 0.0239 0.1036 0.3883
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0043 0.0043
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0047 0.0047
Toxoplasma gondii exonuclease III APE 0.0022 0.0045 0.0728
Giardia lamblia Pyruvate kinase 0.0033 0.0094 0.017
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.001 0.0168
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0005 0.0009
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.0298 0.054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1219 0.5519 1
Brugia malayi POT family protein 0.0081 0.0313 0.0787
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0156 0.0282
Giardia lamblia Kinase, CMGC MAPK 0.0106 0.0429 0.0777
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0037 0.0037
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0043 0.0107
Echinococcus multilocularis dna polymerase eta 0.006 0.022 0.022
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0094 0.017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0554 0.2076
Schistosoma mansoni transcription factor btf3 0.0146 0.0612 0.0612
Echinococcus granulosus geminin 0.0168 0.0711 0.0711
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.001 0.0019
Schistosoma mansoni hypothetical protein 0.0168 0.0711 0.0711
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1304 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0045 0.0342
Echinococcus multilocularis musashi 0.0058 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0094 0.0236
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0328 0.1444 0.5415
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0056 0.0921
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0056 0.0211
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0344 0.0344
Schistosoma mansoni ap endonuclease 0.0022 0.0045 0.0045
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0045 0.0149 0.0374
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0029 0.0225
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0043 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0149 0.1141
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.0149 0.1141
Entamoeba histolytica phosphofructokinase, putative 0.0239 0.1036 0.1876
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0043 0.0107
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0044 0.0044
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0045 0.0167
Trichomonas vaginalis helicase, putative 0.0014 0.0009 0.0016
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0005 0.008
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0045 0.0167
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0043 0.0107
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0043 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0047 0.0084
Brugia malayi ecdysteroid receptor 0.0022 0.0043 0.0107
Echinococcus granulosus phd:f box containing protein 0.0018 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0043 0.0107
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0028 0.0028
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.022 0.1686
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0005 0.0005
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0005 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0043 0.0107
Loa Loa (eye worm) POT family protein 0.0081 0.0313 0.0787
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0043 0.0043
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0047 0.0047
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0367 0.0809
Entamoeba histolytica hypothetical protein 0.0013 0.0005 0.0009
Brugia malayi chromobox protein homolog 3 0.0013 0.0005 0.0012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.0149 0.1141
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0047 0.0047
Toxoplasma gondii NADPH-glutathione reductase 0.0045 0.0149 0.243
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0029 0.0225
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.0149 0.1141
Trypanosoma cruzi DNA polymerase eta, putative 0.006 0.022 0.1686
Leishmania major DNA polymerase eta, putative 0.006 0.022 0.1686
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0172 0.2815
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0047 0.0047
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0045 0.0149 0.5069
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0021 0.0054

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 15 % Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 0.1 ug/mL ChEMBL. 9871731
Inhibition (binding) = 15 % Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 0.1 ug/mL ChEMBL. 9871731
Inhibition (binding) = 16 % Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 0.1 ug/mL ChEMBL. 9871731
Inhibition (binding) = 16 % Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 0.1 ug/mL ChEMBL. 9871731
Inhibition (binding) = 37 % Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 1 microg/ml ChEMBL. 9871731
Inhibition (binding) = 37 % Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 1 microg/ml ChEMBL. 9871731
Inhibition (binding) = 41 % Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 10 microg/ml ChEMBL. 9871731
Inhibition (binding) = 41 % Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 10 microg/ml ChEMBL. 9871731
Inhibition (binding) = 73 % Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 1 microg/ml ChEMBL. 9871731
Inhibition (binding) = 73 % Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 1 microg/ml ChEMBL. 9871731
Inhibition (binding) = 85 % Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 10 microg/ml ChEMBL. 9871731
Inhibition (binding) = 85 % Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 10 microg/ml ChEMBL. 9871731

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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