Detailed information for compound 20886

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.35 | Formula: C16H13FN2O2S
  • H donors: 1 H acceptors: 3 LogP: 3.06 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)c1nc([nH]c1c1ccccc1)S(=O)(=O)C
  • InChi: 1S/C16H13FN2O2S/c1-22(20,21)16-18-14(11-6-3-2-4-7-11)15(19-16)12-8-5-9-13(17)10-12/h2-10H,1H3,(H,18,19)
  • InChiKey: CIEGACYZMALHNL-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0024 0.0122 0.0203
Brugia malayi RE15519p 0.0052 0.0466 0.0774
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0466 0.0605
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Echinococcus granulosus glycine receptor subunit beta 0.0024 0.0122 0.0131
Schistosoma mansoni biogenic amine receptor 0.0052 0.0466 0.0605
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0027 0.0006
Echinococcus granulosus g protein coupled receptor 0.0052 0.0466 0.0579
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0466 0.0605
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0016 0.0021 0.0377
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0228 0.2665 0.3462
Schistosoma mansoni amine GPCR 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0466 0.0446
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0057 0.0037
Echinococcus multilocularis expressed conserved protein 0.0093 0.098 0.0961
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0212 0.0275
Mycobacterium tuberculosis Conserved protein 0.0035 0.0262 0.0896
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0086
Echinococcus multilocularis protein patched 0.0042 0.035 0.0329
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0122 0.0101
Mycobacterium ulcerans beta-lactamase 0.0035 0.0262 0.148
Loa Loa (eye worm) fibroinase 0.0052 0.0467 0.0606
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0466 0.0579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Schistosoma mansoni hypothetical protein 0.0041 0.0331 0.0429
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0052 0.5865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0024 0.0122 0.0203
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0262 0.0896
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0262 0.0704
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0277 0.3282 0.4262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0467 0.1304
Schistosoma mansoni cpg binding protein 0.0036 0.0273 0.0355
Trypanosoma cruzi ISWI complex protein 0.0047 0.0404 0.123
Plasmodium vivax unspecified product 0.0016 0.0021 0.0377
Echinococcus granulosus cathepsin l1 0.0037 0.0286 0.0345
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0202 0.0529
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1587 0.5957
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0024 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0558 0.5292
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0048 0.0421 0.0547
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3437 1
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0466 0.0579
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0057 0.0075
Brugia malayi Cathepsin L-like precursor 0.0052 0.0467 0.0775
Echinococcus granulosus survival motor neuron protein 1 0.0479 0.5808 0.7536
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.0067
Schistosoma mansoni hypothetical protein 0.0052 0.0466 0.0605
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0066 0.0086
Schistosoma mansoni nAChR subunit 0.0024 0.0122 0.0158
Trichomonas vaginalis esterase, putative 0.0035 0.0262 0.0704
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0178 0.0231
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0466 0.0774
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0052 0.0471 0.0451
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0466 0.0579
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0024 0.0122 0.0131
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0467 0.1422
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0421 0.1171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0466 0.0579
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0122 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0202 0.1741
Echinococcus granulosus expressed conserved protein 0.0093 0.098 0.1249
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0466 0.0579
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0466 0.0446
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0058 0.0177
Schistosoma mansoni neuropeptide receptor 0.0052 0.0466 0.0605
Onchocerca volvulus 0.0052 0.0466 0.0803
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.2665 0.3444
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1055 0.1037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3437 1
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0286 0.0776
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0202 0.0335
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0097 0.0295
Schistosoma mansoni ferritin light chain 0.0017 0.0031 0.0041
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0466 0.0446
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0466 0.0605
Echinococcus multilocularis protein dispatched 1 0.0048 0.0425 0.0405
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0262 0.0704
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0202 0.0529
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0024 0.0122 0.0158
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0027
Schistosoma mansoni zinc finger protein 0.0047 0.0404 0.0524
Brugia malayi Cytochrome P450 family protein 0.0029 0.0178 0.0296
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0021 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0466 0.0579
Schistosoma mansoni biogenic amine receptor 0.0052 0.0466 0.0605
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0269 0.4823
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0467 0.8305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0075
Echinococcus multilocularis nAChR subunit 0.0024 0.0122 0.0101
Brugia malayi G-protein coupled receptor 0.0052 0.0466 0.0774
Plasmodium vivax vivapain-1 0.0031 0.0202 0.3617
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0262 0.0797
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0466 0.0579
Onchocerca volvulus 0.0052 0.0467 0.0805
Echinococcus granulosus serotonin receptor 0.0052 0.0466 0.0579
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0262 0.0241
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.0466 0.0446
Brugia malayi cathepsin L-like cysteine proteinase 0.0016 0.0021 0.0035
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0122 0.0158
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0466 0.0605
Schistosoma mansoni histamine h1 receptor 0.0052 0.0466 0.0605
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0467 0.1304
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0269 0.0924
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0058 0.0037
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0262 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Schistosoma mansoni cpg binding protein 0.0036 0.0273 0.0355
Schistosoma mansoni hypothetical protein 0.051 0.6197 0.8048
Echinococcus granulosus neuropeptide receptor 0.0052 0.0466 0.0579
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0262 0.0896
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0262 0.4692
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0558 0.0538
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0122 0.0158
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.0466 0.0579
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Onchocerca volvulus 0.0029 0.018 0.0287
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0466 0.0605
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0057 0.0679
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0052 0.0131
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2645 1
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0466 0.0446
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Schistosoma mansoni opsin-like receptor 0.0052 0.0466 0.0605
Schistosoma mansoni biogenic amine receptor 0.0052 0.0466 0.0605
Onchocerca volvulus 0.0024 0.0122 0.0182
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0021 0.0377
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0262 0.034
Echinococcus multilocularis expressed protein 0.0017 0.0031 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0262 0.0704
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0122 0.0203
Leishmania major cathepsin L-like protease 0.0052 0.0467 0.4385
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0466 0.0579
Brugia malayi Cathepsin L-like precursor 0.0052 0.0467 0.0775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Loa Loa (eye worm) hypothetical protein 0.0036 0.0269 0.0349
Schistosoma mansoni nAChR subunit 0.0024 0.0122 0.0158
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0052 0.0931
Echinococcus granulosus glycine receptor subunit beta 0.0024 0.0122 0.0131
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0421 0.2505
Schistosoma mansoni DNA polymerase eta 0.0019 0.0058 0.0075
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0466 0.0579
Echinococcus granulosus neuropeptide receptor A26 0.0052 0.0466 0.0579
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0607 0.0789
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0024 0.0122 0.0101
Echinococcus granulosus geminin 0.051 0.6197 0.8043
Toxoplasma gondii cathepsin CPL 0.0052 0.0467 0.4419
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0262 0.034
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0262 0.0896
Schistosoma mansoni hypothetical protein 0.0068 0.0667 0.0866
Echinococcus granulosus neuropeptide receptor 0.0052 0.0466 0.0579
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0066 0.0202
Loa Loa (eye worm) hypothetical protein 0.0151 0.171 0.2221
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0558 0.5321
Brugia malayi Cathepsin L-like precursor 0.0037 0.0286 0.0475
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0058 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0467 0.1304
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.0471 0.0611
Onchocerca volvulus 0.0052 0.0466 0.0803
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0212 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0466 0.0605
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.1029 0.2952
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0027 0.0083
Schistosoma mansoni adenoreceptor 0.0052 0.0466 0.0605
Echinococcus multilocularis serotonin receptor 0.0052 0.0466 0.0446
Brugia malayi larval opioid receptor 0.0052 0.0466 0.0774
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.009
Loa Loa (eye worm) cathepsin B 0.0097 0.1029 0.1337
Schistosoma mansoni DNA ligase IV 0.002 0.0066 0.0086
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0066 0.1189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3437 1
Schistosoma mansoni hypothetical protein 0.0052 0.0466 0.0605
Schistosoma mansoni lipoxygenase 0.0019 0.0057 0.0075
Leishmania major cathepsin L-like protease 0.0052 0.0467 0.4385
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0024 0.0122 0.0131
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0066 0.011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0052 0.006
Onchocerca volvulus 0.0052 0.0466 0.0803
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0467 0.1304
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0097 0.0222
Onchocerca volvulus 0.0037 0.0286 0.0478
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.3437 1
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0202 0.0529
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0027 0.0008
Trichomonas vaginalis ran, putative 0.0022 0.0097 0.0222
Schistosoma mansoni hypothetical protein 0.0031 0.0212 0.0275
Echinococcus granulosus tar DNA binding protein 0.0064 0.0615 0.0773
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0202 0.0335
Onchocerca volvulus 0.0052 0.0467 0.0805
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0058 0.0308
Loa Loa (eye worm) hypothetical protein 0.0059 0.0558 0.0724
Entamoeba histolytica cysteine protease, putative 0.0052 0.0467 0.1304
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0133
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0021 0.0027
Leishmania major hypothetical protein, conserved 0.0035 0.0262 0.2339
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0467 0.0805
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0466 0.0579
Echinococcus granulosus snurportin 1 0.063 0.77 1
Schistosoma mansoni patched 1 0.0042 0.035 0.0454
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0466 0.0605
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0466 0.0605
Plasmodium vivax unspecified product 0.0031 0.0202 0.3617
Leishmania major cathepsin L-like protease 0.0052 0.0467 0.4385
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0212 0.0248
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0027 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0021 0.0035
Onchocerca volvulus 0.0052 0.0467 0.0805
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0467 0.0447
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0262 0.2339
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0058 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0058 0.0096
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0202 0.0262
Brugia malayi G protein-coupled receptor 0.0052 0.0466 0.0774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0286 0.0776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0466 0.0605
Echinococcus multilocularis cathepsin b 0.0277 0.3282 0.3267
Brugia malayi Cathepsin L-like precursor 0.0052 0.0467 0.0775
Onchocerca volvulus Putative nachr subunit 0.0024 0.0122 0.0182
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0097 0.1029 0.3137
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0035 0.0262 0.034
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0467 0.0447
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0097 0.0751
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0615 0.0798
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0466 0.0774
Brugia malayi CHE-14 protein 0.0042 0.035 0.0581
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0027 0.0061
Onchocerca volvulus 0.0052 0.0467 0.0805
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.0158
Loa Loa (eye worm) hypothetical protein 0.0035 0.0262 0.034
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0052 0.0247
Leishmania major hypothetical protein, conserved 0.0047 0.0404 0.3757
Brugia malayi hypothetical protein 0.002 0.0066 0.011
Echinococcus granulosus fmrfamide receptor 0.0052 0.0466 0.0579
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0466 0.0446
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0466 0.0605
Echinococcus granulosus cysteine protease 0.0031 0.0202 0.0235
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0027
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0122 0.0101
Echinococcus granulosus cathepsin l1 0.0052 0.0467 0.058
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0202 0.0615
Echinococcus multilocularis snurportin 1 0.063 0.77 0.7695
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0244 0.083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0467 0.1304
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0024 0.0122 0.0131
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0122 0.0131
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0262 0.148
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0066 0.0133
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0421 0.0699
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0466 0.0579
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0024 0.0122 0.0131
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0002 0.0004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0058 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0479 0.0622
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Schistosoma mansoni neuropeptide receptor 0.0052 0.0466 0.0605
Schistosoma mansoni lipoxygenase 0.0053 0.0486 0.0631
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0466 0.0446
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0016 0.0021 0.0377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3437 1
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0269 0.462
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0016 0.0021 0.0027
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0016 0.0021 0.0377
Loa Loa (eye worm) hypothetical protein 0.0216 0.2521 0.3273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0071 0.0701 0.0681
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0122 0.0131
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0097 0.1736
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0052 0.0067
Schistosoma mansoni apoferritin-2 0.0017 0.0031 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0466 0.0446
Onchocerca volvulus 0.0052 0.0466 0.0803
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus granulosus Protein patched homolog 1 0.0042 0.035 0.0428
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0122 0.0158
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0202 0.3367
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0122 0.0131
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0466 0.0446
Brugia malayi Cathepsin L-like precursor 0.0052 0.0467 0.0775
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0467 0.0606
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0016 0.0021 0.0035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0466 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0466 0.0579
Loa Loa (eye worm) hypothetical protein 0.0035 0.0262 0.034
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0058 0.0075
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0058 0.0177
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.1075 0.1395
Echinococcus granulosus cathepsin L 0.0031 0.0202 0.0235
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1059 0.1759
Echinococcus granulosus somatostatin receptor 0.0052 0.0466 0.0579
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0066 0.0449
Onchocerca volvulus 0.0035 0.0262 0.0434
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0466 0.0579
Echinococcus granulosus muscleblind protein 0.0151 0.171 0.2199
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0467 0.1422
Schistosoma mansoni opsin-like receptor 0.0052 0.0466 0.0605
Echinococcus multilocularis cathepsin b 0.0277 0.3282 0.3267
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0212 0.0351
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0667 0.1107
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0467 0.1422
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.3437 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0466 0.0446
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0466 0.0605
Echinococcus multilocularis cathepsin L 0.0031 0.0202 0.0181
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0202 0.0529
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0066 0.0449
Brugia malayi cathepsin L-like precursor 0.0037 0.0286 0.0475
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0421 0.2505
Schistosoma mansoni hypothetical protein 0.051 0.6197 0.8048
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Brugia malayi sulfakinin receptor protein 0.0052 0.0466 0.0774
Onchocerca volvulus 0.002 0.0066 0.0082
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0057 0.1031
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0466 0.0579
Loa Loa (eye worm) hypothetical protein 0.0183 0.2103 0.2731
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0086
Trichomonas vaginalis ferritin, putative 0.0017 0.0031 0.0031
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0466 0.0446
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0467 0.1304
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0021 0.0027
Onchocerca volvulus 0.0052 0.0466 0.0803
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0466 0.0605
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0021 0.0027
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Brugia malayi fibroinase precursor 0.0016 0.0021 0.0035
Brugia malayi RNA binding protein 0.0064 0.0615 0.1021
Brugia malayi GnHR receptor homolog 0.0052 0.0466 0.0774
Brugia malayi ORL1-like opioid receptor 0.0052 0.0466 0.0774
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0467 0.0606
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0058 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0275
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0086
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0615 0.0798
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0027 0.0035
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0097 0.0126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0277 0.3282 0.4262
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0027
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0052 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0202 0.0615
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0058 0.0177
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0058 0.0308
Brugia malayi follicle stimulating hormone receptor 0.0052 0.0466 0.0774
Brugia malayi hypothetical protein 0.0019 0.0057 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0615 0.0798
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0184 0.212 0.2104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0286 0.0776
Echinococcus granulosus g protein coupled receptor 0.0052 0.0466 0.0579
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0466 0.0446
Toxoplasma gondii exonuclease III APE 0.0019 0.0052 0.0306
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0202 0.0615
Brugia malayi Dopamine receptor protein 2 0.0052 0.0466 0.0774
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.1041 0.1729
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0057 0.0037
Brugia malayi Bromodomain containing protein 0.0117 0.1282 0.2129
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0024 0.0122 0.0203
Mycobacterium ulcerans hypothetical protein 0.0048 0.0421 0.2505
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0122 0.0158
Brugia malayi Importin beta-1 subunit 0.0059 0.0558 0.0926
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.009
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.3437 1
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0122 0.0158
Brugia malayi Cathepsin L-like precursor 0.0052 0.0467 0.0775
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0133
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0066 0.0133
Onchocerca volvulus 0.0052 0.0466 0.0803
Brugia malayi hypothetical protein 0.0479 0.5808 0.9646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0418 0.1162
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0466 0.0579
Onchocerca volvulus 0.0098 0.1041 0.1842
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0086
Brugia malayi RNA, U transporter 1 0.0168 0.1919 0.3186
Loa Loa (eye worm) bromodomain containing protein 0.0054 0.0494 0.0642
Leishmania major importin beta-1 subunit, putative 0.0048 0.0418 0.3899
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0024 0.0122 0.0158
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0421 0.2505
Schistosoma mansoni nAChR subunit 0.0024 0.0122 0.0158
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0262 0.148
Echinococcus multilocularis allatostatin A receptor 0.0052 0.0466 0.0446
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.0466 0.0605
Onchocerca volvulus 0.0052 0.0466 0.0803
Toxoplasma gondii cathepsin B 0.0097 0.1029 1
Loa Loa (eye worm) LGC-31 protein 0.0024 0.0122 0.0158
Onchocerca volvulus 0.0459 0.5558 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0615 0.0798
Loa Loa (eye worm) hypothetical protein 0.0052 0.0469 0.0609
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0024 0.0122 0.0158
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0421 0.1505
Echinococcus granulosus replication factor c subunit 1 0.002 0.0066 0.0059
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0466 0.0446
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0212 0.0191
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0122 0.0203
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0066 0.0133
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0066 0.011
Loa Loa (eye worm) hypothetical protein 0.0117 0.1285 0.1669
Brugia malayi Melatonin receptor type 1A 0.0052 0.0466 0.0774
Schistosoma mansoni cathepsin S (C01 family) 0.0016 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Echinococcus granulosus GPCR family 2 0.0031 0.0212 0.0248
Loa Loa (eye worm) hypothetical protein 0.0479 0.5808 0.7543
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1055 0.1347
Brugia malayi neuropeptide F receptor 0.0052 0.0466 0.0774
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.2665 0.265
Echinococcus multilocularis glycine receptor subunit beta 0.0024 0.0122 0.0101
Schistosoma mansoni loxhd1 0.0019 0.0057 0.0075
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0421 0.2505
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0421 0.1171
Loa Loa (eye worm) ctsf protein 0.0052 0.0467 0.0606
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0058 0.0177
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0558 0.5292
Brugia malayi G-protein coupled receptor 0.0052 0.0466 0.0774
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0466 0.0446
Schistosoma mansoni nAChR subunit 0.0024 0.0122 0.0158
Loa Loa (eye worm) RNA binding protein 0.0064 0.0615 0.0798
Brugia malayi Cathepsin L-like precursor 0.0037 0.0286 0.0475
Schistosoma mansoni opsin-like receptor 0.0052 0.0466 0.0605
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0016 0.0021 0.0377
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0466 0.0605
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0122 0.0101
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0466 0.0446
Schistosoma mansoni ran 0.0022 0.0097 0.0126
Brugia malayi hypothetical protein 0.0019 0.0057 0.0095
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0269 0.1527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0262 0.034
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0262 0.0313
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0466 0.0446
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0071 0.0701 0.091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0228 0.2665 0.4426
Onchocerca volvulus 0.0052 0.0467 0.0805
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0421 0.2505
Loa Loa (eye worm) hypothetical protein 0.0037 0.0286 0.0371
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0184 0.212 0.2734
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0467 0.0805
Onchocerca volvulus 0.0024 0.0122 0.0182
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0058 0.0308
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1587 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0467 0.0447
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0097 0.0695
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0467 0.1304
Schistosoma mansoni cpg binding protein 0.0029 0.018 0.0234
Brugia malayi isocitrate dehydrogenase 0.0017 0.0027 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0021 0.0377
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0466 0.0446
Echinococcus multilocularis cpg binding protein 0.0036 0.0273 0.0253
Brugia malayi Bromodomain containing protein 0.0231 0.2704 0.4491
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0421 0.2505
Echinococcus granulosus expressed protein 0.0017 0.0031 0.0014
Schistosoma mansoni nAChR subunit 0.0024 0.0122 0.0158
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0027 0.0006
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Trypanosoma brucei unspecified product 0.0019 0.0058 0.0308
Brugia malayi hypothetical protein 0.011 0.1196 0.1986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0202 0.1741
Schistosoma mansoni neuropeptide receptor 0.0052 0.0466 0.0605
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0467 0.1304
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.1196 0.153
Echinococcus granulosus sex peptide receptor 0.0052 0.0466 0.0579
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0286 0.0371
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0615 0.1021
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 0.0466 0.0605
Schistosoma mansoni hypothetical protein 0.0031 0.0212 0.0275
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0466 0.0446
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0027
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0027 0.0061
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0466 0.0605
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0466 0.0605
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0466 0.0579
Echinococcus granulosus dna polymerase eta 0.0019 0.0058 0.0048
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0202 0.0615
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0086
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0027 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0122 0.0203
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0122 0.0101
Loa Loa (eye worm) hypothetical protein 0.0053 0.0479 0.0622
Onchocerca volvulus 0.0024 0.0122 0.0182
Leishmania major DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0418 0.1162
Brugia malayi beta-lactamase family protein 0.0035 0.0262 0.0434
Brugia malayi CXXC zinc finger family protein 0.0029 0.018 0.0299
Schistosoma mansoni rab6-interacting 0.0019 0.0057 0.0075
Onchocerca volvulus 0.0052 0.0466 0.0803
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.0466 0.0803
Schistosoma mansoni cathepsin B (C01 family) 0.0016 0.0021 0.0027
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0467 0.0447
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0466 0.0605
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0058 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0467 0.1304
Schistosoma mansoni ran 0.0022 0.0097 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0097 0.0099
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0024 0.0122 0.0101
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1059 0.1759
Echinococcus multilocularis cysteine protease 0.0052 0.0467 0.0447
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0615 0.0798
Schistosoma mansoni amine GPCR 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0037 0.0286 0.0371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.2665 0.3462
Brugia malayi PHD-finger family protein 0.0078 0.0791 0.1314
Echinococcus multilocularis zinc finger protein 0.0061 0.0588 0.0568
Schistosoma mansoni nAChR subunit 0.0024 0.0122 0.0158
Echinococcus multilocularis neuropeptide s receptor 0.0052 0.0466 0.0446
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0615 0.0595
Brugia malayi Cation transporter family protein 0.0024 0.0122 0.0203
Brugia malayi topoisomerase 0.002 0.0066 0.011
Echinococcus multilocularis serotonin receptor 0.0052 0.0466 0.0446
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Onchocerca volvulus 0.0052 0.0466 0.0803
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0466 0.0605
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0052 0.0031
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0466 0.0605
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0466 0.0774
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0479 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0027 0.0035
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0421 0.2505
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0066 0.0133
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0262 0.0896
Brugia malayi Cation transporter family protein 0.0024 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0036 0.0269 0.0349
Schistosoma mansoni apoferritin-2 0.0017 0.0031 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Onchocerca volvulus 0.0052 0.0466 0.0803
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0212 0.0248
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.0466 0.0803
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0486 0.0606
Brugia malayi TAR-binding protein 0.0064 0.0615 0.1021
Plasmodium vivax vivapain-3 0.0031 0.0202 0.3617
Echinococcus granulosus hypothetical protein 0.0052 0.0466 0.0579
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1059 0.1375
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.2665 0.3444
Loa Loa (eye worm) hypothetical protein 0.0048 0.0421 0.0547
Onchocerca volvulus 0.0052 0.0467 0.0805
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0467 0.1422
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0466 0.0446
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0016 0.0021 0.0377
Echinococcus granulosus g protein coupled receptor 0.0052 0.0466 0.0579
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Giardia lamblia Cathepsin B precursor 0.0097 0.1029 0.2952
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0097 0.0295
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0016 0.0021 0.0377
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0066 0.0391
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.063 0.77 1
Brugia malayi DKFZp564C0469 protein 0.002 0.0066 0.011
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.0066 0.0224
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Onchocerca volvulus 0.0024 0.0122 0.0182
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0262 0.0704
Brugia malayi Serotonin receptor 0.0052 0.0466 0.0774
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0466 0.0774
Plasmodium vivax importin-beta 2, putative 0.0059 0.0558 1
Leishmania major GTP-binding protein, putative 0.0022 0.0097 0.0695
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0016 0.0021 0.0377
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0466 0.0446
Loa Loa (eye worm) hypothetical protein 0.0035 0.0262 0.034
Schistosoma mansoni hypothetical protein 0.0031 0.0212 0.0275
Plasmodium vivax vivapain-2 0.0052 0.0467 0.8369
Leishmania major cathepsin L-like protease 0.0052 0.0467 0.4385
Echinococcus granulosus nibrin 0.002 0.0066 0.0059
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0467 0.1304
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0202 0.0529
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0024 0.0122 0.0158
Echinococcus granulosus dna polymerase kappa 0.0019 0.0058 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0466 0.0446
Loa Loa (eye worm) hypothetical protein 0.0048 0.0421 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.035 0.0962
Mycobacterium tuberculosis Conserved protein 0.0035 0.0262 0.0896
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0027 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0269 0.0349
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0262 0.0896
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0466 0.0774
Onchocerca volvulus 0.0048 0.0421 0.0722
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.3437 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0052 0.0575
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus multilocularis sex peptide receptor 0.0052 0.0466 0.0446
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0024 0.0122 0.0158
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0466 0.0446
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0467 0.1304
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Schistosoma mansoni hypothetical protein 0.0041 0.0331 0.0429
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Schistosoma mansoni hypothetical protein 0.0098 0.1041 0.1352
Echinococcus granulosus cpg binding protein 0.0036 0.0273 0.0329
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0467 0.058
Loa Loa (eye worm) hypothetical protein 0.0037 0.0286 0.0371
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0466 0.0579
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0466 0.0446
Onchocerca volvulus 0.0052 0.0466 0.0803
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0066 0.0045
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0262 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0467 0.1304
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0466 0.0579
Schistosoma mansoni hypothetical protein 0.011 0.1196 0.1553
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0277 0.3282 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0262 0.148
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.035 0.0428
Loa Loa (eye worm) beta-lactamase 0.0035 0.0262 0.034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0466 0.0446
Schistosoma mansoni hypothetical protein 0.0041 0.0331 0.0429
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0122 0.0203
Onchocerca volvulus 0.0052 0.0466 0.0803
Echinococcus multilocularis muscleblind protein 1 0.0151 0.171 0.1692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0466 0.0605
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0244 0.083
Loa Loa (eye worm) hypothetical protein 0.0052 0.0467 0.0606
Echinococcus multilocularis geminin 0.051 0.6197 0.6189
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0467 0.8305
Brugia malayi beta-lactamase 0.0035 0.0262 0.0434
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0027 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0466 0.0579
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0212 0.0351
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0097 0.0161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0466 0.0605
Entamoeba histolytica Ran family GTPase 0.0022 0.0097 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0466 0.0446
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0024 0.0122 0.0158
Echinococcus granulosus cathepsin b 0.0277 0.3282 0.4246
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0421 0.393
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0479 0.0596
Trypanosoma cruzi ISWI complex protein 0.0047 0.0404 0.123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0075
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0466 0.0446
Echinococcus granulosus fetal alzheimer antigen falz 0.0071 0.0701 0.0885
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0466 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0027
Echinococcus granulosus neuropeptide s receptor 0.0052 0.0466 0.0579
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0421 0.1505
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0021 0.0035
Entamoeba histolytica hypothetical protein 0.002 0.0066 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0467 0.4385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0075
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.0067
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0421 0.2505
Echinococcus multilocularis cysteine protease 0.0052 0.0467 0.0447
Schistosoma mansoni hypothetical protein 0.0052 0.0466 0.0605
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3437 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0058 0.0108
Onchocerca volvulus 0.0024 0.0122 0.0182
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0052 0.009
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Schistosoma mansoni importin beta-1 0.0059 0.0558 0.0724
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0244 0.083
Mycobacterium tuberculosis Conserved protein 0.0035 0.0262 0.0896
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0202 0.0529
Onchocerca volvulus 0.0052 0.0466 0.0803
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0466 0.0605
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0024 0.0122 0.0203
Plasmodium falciparum importin beta, putative 0.0059 0.0558 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.0466 0.0605
Brugia malayi Dopamine receptor protein 1 0.0052 0.0466 0.0774
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0052 0.0158
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0052 0.004
Schistosoma mansoni hypothetical protein 0.063 0.77 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0269 0.0349
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0467 0.058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0244 0.083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Echinococcus multilocularis nibrin 0.002 0.0066 0.0045
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0466 0.0605
Schistosoma mansoni ferritin 0.0017 0.0031 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0202 0.0529
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0467 0.0775
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0202 0.0529
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0615 0.0798
Schistosoma mansoni hypothetical protein 0.0063 0.0607 0.0789
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0466 0.0446
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0277 0.3282 0.4262
Brugia malayi hypothetical protein 0.0459 0.5558 0.9231
Giardia lamblia Cathepsin B precursor 0.0097 0.1029 0.2952
Echinococcus granulosus ferritin 0.0017 0.0031 0.0014
Brugia malayi hypothetical protein 0.002 0.0066 0.011
Loa Loa (eye worm) hypothetical protein 0.0099 0.1059 0.1375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Onchocerca volvulus 0.0019 0.0057 0.0066
Brugia malayi AKH receptor 0.0052 0.0466 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0133
Schistosoma mansoni neuropeptide receptor 0.0052 0.0466 0.0605
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0021 0.0027
Echinococcus multilocularis GPCR, family 2 0.0031 0.0212 0.0191
Echinococcus multilocularis muscleblind protein 0.0151 0.171 0.1692
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.2665 0.3462
Schistosoma mansoni survival motor neuron protein 0.0098 0.1041 0.1352
Loa Loa (eye worm) hypothetical protein 0.0124 0.1375 0.1786
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0052 0.0086
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0466 0.0605
Echinococcus multilocularis glycine receptor subunit beta 0.0024 0.0122 0.0101
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0037 0.0286 0.0871
Trypanosoma brucei ISWI complex protein 0.0047 0.0404 0.3757
Schistosoma mansoni amine GPCR 0.0052 0.0466 0.0605
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0467 0.1304
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0122 0.0158
Onchocerca volvulus 0.0019 0.0057 0.0066
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0467 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.1586 0.2038
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0466 0.0579
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0066 1
Onchocerca volvulus 0.0052 0.0467 0.0805
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0016 0.0021 0.0377
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0021 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0421 0.1171
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0058 0.0108
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Loa Loa (eye worm) hypothetical protein 0.0132 0.1469 0.1907
Giardia lamblia Cathepsin B precursor 0.0097 0.1029 0.2952
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0466 0.0579
Echinococcus granulosus zinc finger protein 0.0061 0.0588 0.0738
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.2665 0.3462
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0097 0.1029 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0418 0.1274
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0466 0.0579
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0058 0.017
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0031 0.0017
Schistosoma mansoni myosin xvIII 0.0052 0.0466 0.0605
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0421 0.0699
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.1196 0.1177
Giardia lamblia Replication factor C, subunit 1 0.002 0.0066 0.0133
Schistosoma mansoni hypothetical protein 0.0047 0.0404 0.0524
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0122 0.0203
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0466 0.0774
Schistosoma mansoni rab6-interacting 0.0019 0.0057 0.0075
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0122 0.0101
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0057 0.0047
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0024 0.0122 0.0203
Schistosoma mansoni hypothetical protein 0.0031 0.0212 0.0275
Loa Loa (eye worm) hypothetical protein 0.0036 0.0269 0.0349
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0466 0.0605
Echinococcus granulosus methyl CpG binding domain protein 2 0.0052 0.0471 0.0586
Loa Loa (eye worm) cysteine protease 0.0052 0.0467 0.0606
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0202 0.0235
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0066 0.0133
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0467 0.0606
Brugia malayi excitatory GABA receptor EXP-1A 0.0024 0.0122 0.0203
Echinococcus multilocularis survival motor neuron protein 1 0.0479 0.5808 0.5799
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.011 0.1192 0.1525
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0122 0.0131
Schistosoma mansoni ferritin 0.0017 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Leishmania major cathepsin L-like protease 0.0052 0.0467 0.4385
Schistosoma mansoni bromodomain containing protein 0.0015 0.0003 0.0004
Echinococcus multilocularis RUN 0.0019 0.0057 0.0037
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0031 0.0017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0122 0.0131
Loa Loa (eye worm) hypothetical protein 0.0068 0.0667 0.0866
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0122 0.0101
Schistosoma mansoni cathepsin C 0.0016 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0486 0.0466
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0418 0.1162
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.035 0.0329
Loa Loa (eye worm) hypothetical protein 0.0277 0.3282 0.4262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0466 0.0605
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0466 0.0446
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0466 0.0446
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0466 0.0605
Onchocerca volvulus 0.0052 0.0466 0.0803
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0466 0.0446
Echinococcus granulosus allatostatin A receptor 0.0052 0.0466 0.0579
Brugia malayi cathepsin F-like cysteine proteinase 0.0016 0.0021 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0584 0.0758
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0466 0.0605
Schistosoma mansoni topbp1 0.002 0.0066 0.0086
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0466 0.0579
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0058 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3437 1
Echinococcus multilocularis somatostatin receptor 0.0052 0.0466 0.0446
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Loa Loa (eye worm) hypothetical protein 0.0459 0.5558 0.7219
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0615 0.0798
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0122 0.0101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0262 0.034
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0066 0.0844
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0466 0.0446
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1055 0.1753
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0024 0.0122 0.0101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0277 0.3282 0.4262
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.1586 0.1568
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0086
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0466 0.0605
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0058 0.0108
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0466 0.0446
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0262 0.0704
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0466 0.0446
Schistosoma mansoni nAChR subunit 0.0024 0.0122 0.0158
Toxoplasma gondii ABC1 family protein 0.0035 0.0262 0.2386
Mycobacterium ulcerans lipase LipD 0.0035 0.0262 0.148
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0066 0.0202
Schistosoma mansoni amine GPCR 0.0212 0.2466 0.3203
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Schistosoma mansoni topbp1 0.002 0.0066 0.0086
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0057 0.0047
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0066 0.0202
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0467 0.8305
Schistosoma mansoni ferritin light chain 0.0017 0.0031 0.0041
Brugia malayi Doublecortin family protein 0.0019 0.0057 0.0095
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0021 0.0035
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0466 0.0605
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0021 0.0377
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0466 0.0446
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.018 0.0234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3437 1
Echinococcus multilocularis ferritin 0.0017 0.0031 0.001
Echinococcus granulosus RUN 0.0019 0.0057 0.0047
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0466 0.0446
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0466 0.0446
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0016 0.0021 0.0027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.1029 0.1337
Brugia malayi cathepsin L precursor 0.0016 0.0021 0.0035
Schistosoma mansoni hypothetical protein 0.0041 0.0331 0.0429
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.0286 0.0475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Entamoeba histolytica hypothetical protein 0.011 0.1196 0.3439
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0158
Onchocerca volvulus 0.0035 0.0262 0.0434
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.035 0.0454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0021 0.0064
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0466 0.0579
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0202 0.0615
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0466 0.0774
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0308
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Loa Loa (eye worm) hypothetical protein 0.0042 0.035 0.0454
Loa Loa (eye worm) hypothetical protein 0.0171 0.1963 0.2549
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0421 0.2505
Schistosoma mansoni zinc finger protein 0.0061 0.0588 0.0763
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0021 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0466 0.0605
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0024 0.0122 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0075
Leishmania major cathepsin L-like protease 0.0052 0.0467 0.4385
Loa Loa (eye worm) hypothetical protein 0.0035 0.0262 0.034
Schistosoma mansoni ferritin 0.0017 0.0031 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0262 0.0797
Plasmodium vivax vivapain-2 0.0052 0.0467 0.8369
Schistosoma mansoni hypothetical protein 0.0052 0.0466 0.0605
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0421 0.393
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3437 1
Entamoeba histolytica hypothetical protein 0.011 0.1196 0.3439
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.2665 0.265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0467 0.4385
Loa Loa (eye worm) hypothetical protein 0.0099 0.1055 0.1371
Brugia malayi Muscleblind-like protein 0.0151 0.171 0.284
Brugia malayi Cathepsin L-like precursor 0.0052 0.0467 0.0775
Echinococcus granulosus cathepsin b 0.0277 0.3282 0.4246
Schistosoma mansoni ferritin 0.0017 0.0031 0.0041
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0466 0.0579
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0421 0.393
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.0466 0.0446
Brugia malayi Serotonin receptor 0.0496 0.6022 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Onchocerca volvulus 0.0052 0.0466 0.0803
Loa Loa (eye worm) hypothetical protein 0.0151 0.171 0.2221
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Leishmania major DNA polymerase eta, putative 0.0019 0.0058 0.0308
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0066 0.0224
Schistosoma mansoni polycystin 1-related 0.0019 0.0057 0.0075
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0479 0.0459
Entamoeba histolytica cysteine protease, putative 0.0031 0.0202 0.0529
Onchocerca volvulus 0.0052 0.0466 0.0803
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0593 0.567
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0122 0.0131
Mycobacterium leprae Probable lipase LipE 0.0035 0.0262 0.148
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1587 1
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0466 0.0579
Mycobacterium ulcerans hypothetical protein 0.0035 0.0262 0.148
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0466 0.0579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0466 0.0605
Onchocerca volvulus 0.0035 0.0262 0.0434
Entamoeba histolytica hypothetical protein 0.011 0.1196 0.3439
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0421 0.0699
Echinococcus granulosus nAChR subunit 0.0024 0.0122 0.0131
Echinococcus granulosus orexin receptor type 2 0.0052 0.0466 0.0579
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0466 0.0774
Entamoeba histolytica hypothetical protein 0.011 0.1196 0.3439
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0183 0.2103 0.3492
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0057 0.0047
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0016 0.0021 0.0027
Brugia malayi beta-lactamase family protein 0.0035 0.0262 0.0434
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0058 0.0177
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus granulosus importin subunit beta 1 0.0059 0.0558 0.0699
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Echinococcus multilocularis neuropeptide receptor A26 0.0052 0.0466 0.0446
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0467 0.0805
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0052 0.0095
Onchocerca volvulus 0.0024 0.0122 0.0182
Schistosoma mansoni transcription factor LCR-F1 0.011 0.1196 0.1553
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0269 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.011 0.1192 0.1173
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0066 0.0133
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Treponema pallidum DNA ligase (lig) 0.002 0.0066 0.0102
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0058 0.0118
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0097 0.1412
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0066 0.0202
Leishmania major cathepsin L-like protease 0.0052 0.0467 0.4385
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0004
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0202 0.0262
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.0605
Brugia malayi neuropeptide F receptor 0.0052 0.0466 0.0774
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0122 0.0203
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0467 0.1422
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0466 0.0605
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0058 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0021 0.0027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0021 0.0027
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0058 0.0096
Onchocerca volvulus 0.0052 0.0466 0.0803
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0466 0.0579
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0027 0.0006
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0057 0.0037
Schistosoma mansoni bromodomain containing protein 0.0195 0.2257 0.2931
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0262 0.0896
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1055 0.3028
Brugia malayi putative neuropeptide receptor 0.0052 0.0466 0.0774
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0027 0.0487
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0466 0.0605
Brugia malayi hypothetical protein 0.0052 0.0466 0.0774
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0021 0.0064
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0021 0.0027
Brugia malayi Cation transporter family protein 0.0024 0.0122 0.0203
Echinococcus multilocularis dna polymerase eta 0.0019 0.0058 0.0037
Trypanosoma brucei cysteine peptidase C (CPC) 0.0097 0.1029 1
Schistosoma mansoni amine GPCR 0.0052 0.0466 0.0605
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0097 0.0076
Brugia malayi Dopamine receptor 0.0052 0.0466 0.0774
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0024 0.0122 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0467 0.1304
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0027 0.0045
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0021 0.0035
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0466 0.0446
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0466 0.0579
Brugia malayi cathepsin B-like cysteine proteinase 0.0277 0.3282 0.5449
Leishmania major cathepsin L-like protease 0.0052 0.0467 0.4385
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0133
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0058 0.0118
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0202 0.0262
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0058 0.0075
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0021 0.0035
Entamoeba histolytica hypothetical protein 0.0048 0.0418 0.1162
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.0471 0.0611

Activities

Activity type Activity value Assay description Source Reference
Decrease (functional) = 32 % Decrease in paw volume by the effect of compound at a dose of 75 mg/kg ChEMBL. 3875725
ED50 (functional) > 130 mg kg-1 Effective dose determined by mouse phenyl-p-benzoquinone writhing (PQW) assay after peroral administration ChEMBL. 3875725
ED50 (functional) > 130 mg kg-1 Effective dose determined by mouse phenyl-p-benzoquinone writhing (PQW) assay after peroral administration ChEMBL. 3875725

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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