Detailed information for compound 212997

Basic information

Technical information
  • TDR Targets ID: 212997
  • Name: benzyl-dihydroxy-sulfanylidene-$l^{5}-phospha ne
  • MW: 188.184 | Formula: C7H9O2PS
  • H donors: 2 H acceptors: 2 LogP: 1.62 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OP(=S)(Cc1ccccc1)O
  • InChi: 1S/C7H9O2PS/c8-10(9,11)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,8,9,11)
  • InChiKey: DJMQXCFMMJCCFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzyl-dihydroxy-thioxo-phosphorane
  • benzyl-dihydroxy-thioxophosphorane
  • dihydroxy-(phenylmethyl)-sulfanylidene-$l^{5}-phosphane

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0065 0.0051
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.082 0.0876
Schistosoma mansoni lozenge 0.0055 0.0521 0.0525
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0183 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0405 0.0405
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1123 0.154
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0268 0.0292
Echinococcus granulosus tar DNA binding protein 0.0062 0.0616 0.0623
Brugia malayi jmjC domain containing protein 0.0034 0.0268 0.0483
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0096
Loa Loa (eye worm) hypothetical protein 0.0037 0.0301 0.0329
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0002
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0179 0.2062 0.2354
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0252 0.2966 0.2956
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.006 0.058 0.0586
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.1123 0.538
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Loa Loa (eye worm) hypothetical protein 0.0437 0.5265 0.6035
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0172 0.1979 0.9563
Onchocerca volvulus 0.0018 0.0065 0.0096
Onchocerca volvulus 0.0018 0.0065 0.0096
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.006 0.058 0.0747
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0715 0.8716 1
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0268 0.0263
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.1123 0.538
Brugia malayi Cation transporter family protein 0.0018 0.0065 0.0096
Schistosoma mansoni hypothetical protein 0.002 0.0088 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0616 0.0623
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0065 0.0051
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.082 0.3874
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0137 0.0235
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0025 0.0154 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.1979 0.2033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Schistosoma mansoni jumonji domain containing protein 0.0212 0.247 0.2541
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0268 0.0263
Plasmodium vivax protein kinase Crk2 0.0172 0.1979 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.073 0.0741
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.006 0.058 0.0516
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0154 0.0629
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0095 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0271 0.0266
Brugia malayi Importin beta-1 subunit 0.0028 0.0194 0.0342
Echinococcus multilocularis dual specificity 0.0179 0.2062 0.2051
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0065 0.0058
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.006 0.058 0.2819
Plasmodium falciparum protein kinase 5 0.0172 0.1979 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0154 0.0126
Loa Loa (eye worm) hypothetical protein 0.0034 0.0268 0.0292
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0178 0.0047
Plasmodium vivax SET domain protein, putative 0.0029 0.0201 0.0872
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6926 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0072 0.011
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0065 0.0052
Schistosoma mansoni NAD dehydrogenase 0.006 0.058 0.0586
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0368 0.1681
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0179 0.2062 0.9973
Trichomonas vaginalis CMGC family protein kinase 0.0172 0.1979 0.2786
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.1466 0.1503
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0551 0.1022
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.1979 0.2033
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0172 0.1979 0.9563
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0368 0.0366
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0052
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0137 0.0134
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0052
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0154 0.0743
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0194 0.0936
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0715 0.8716 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0065 0.0058
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0125 0.1387 0.1924
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0137 0.0102
Leishmania major eukaryotic initiation factor 4a, putative 0.0125 0.1387 0.6671
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0368 0.0437
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1323 0.1505
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.006 0.058 0.2806
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0068 0.0214
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.006 0.058 0.0598
Loa Loa (eye worm) hypothetical protein 0.0715 0.8716 1
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.006 0.058 0.0747
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0172 0.1979 0.9561
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0068 0.0326
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0104
Brugia malayi jmjC domain containing protein 0.0252 0.2966 0.5621
Treponema pallidum ATP-dependent RNA helicase 0.0125 0.1387 0.1924
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1123 0.154
Trypanosoma brucei cdc2-related kinase 1 0.0172 0.1979 0.9568
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0137 0.0087
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0031 0.0036
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0154 0.0126
Giardia lamblia Kinase, CMGC CDK 0.0172 0.1979 0.2786
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1123 0.1148
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0065 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0031 0.0017
Schistosoma mansoni lamin 0.0057 0.0551 0.0555
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0065 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0125 0.1387 0.6659
Schistosoma mansoni ap endonuclease 0.0018 0.0068 0.0055
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0137 0.0087
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0031 0.0033
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0052
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0096
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0578 0.2684
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0268 0.0292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.005 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0137 0.0555
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0065 0.0052
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0368 0.1681
Loa Loa (eye worm) hypothetical protein 0.0179 0.2068 0.236
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0065 0.0051
Plasmodium falciparum eukaryotic initiation factor 4A 0.0125 0.1387 0.6964
Echinococcus multilocularis cyclin dependent kinase 1 0.0172 0.1979 0.1967
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6926 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.082 0.0807
Onchocerca volvulus Alhambra homolog 0.0059 0.0578 0.1074
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.006 0.058 0.0691
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.082 0.3874
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0368 0.0366
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0268 0.1162
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0025 0.0154 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Plasmodium falciparum importin beta, putative 0.0028 0.0194 0.0834
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.006 0.058 0.0567
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0025 0.0154 0.014
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0045 0.0031
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0081 0.0258
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0072 0.0006
Plasmodium falciparum polyprenol reductase, putative 0.0025 0.0154 0.0629
Brugia malayi Pre-SET motif family protein 0.0202 0.2354 0.4456
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0268 0.0254
Leishmania major DNA polymerase kappa, putative 0.0019 0.0072 0.0235
Echinococcus multilocularis lamin 0.0057 0.0551 0.0537
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.006 0.058 0.2722
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0616 0.0692
Echinococcus multilocularis Ankyrin 0.0014 0.0015 0.0001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0578 0.0648
Echinococcus multilocularis Protein lozenge 0.0055 0.0521 0.0508
Echinococcus multilocularis musashi 0.0057 0.0551 0.0537
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.006 0.058 0.2806
Brugia malayi RNA binding protein 0.0062 0.0616 0.1147
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0291 0.0277
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Entamoeba histolytica protein kinase domain containing protein 0.0179 0.2062 0.2909
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0065 0.0052
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0065 0.0051
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0125 0.1387 0.1924
Onchocerca volvulus 0.0024 0.0137 0.0235
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0405 0.0405
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.1123 0.1275
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0368 0.0354
Brugia malayi Cation transporter family protein 0.0018 0.0065 0.0096
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0031 0.0017
Brugia malayi hypothetical protein 0.0118 0.1311 0.2469
Brugia malayi Death domain containing protein 0.0014 0.0014 0.00000004793
Toxoplasma gondii exonuclease III APE 0.0018 0.0068 0.0178
Brugia malayi cDNA sequence BC016226 0.006 0.058 0.1078
Echinococcus multilocularis zinc finger protein 0.0019 0.0075 0.0061
Schistosoma mansoni lamin 0.0057 0.0551 0.0555
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0068 0.0046
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0183 0.0175
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0081 0.0394
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0065 0.0096
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0368 0.0354
Loa Loa (eye worm) hypothetical protein 0.0437 0.5265 0.6035
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0483 0.0568
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.005 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.0235
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0031 0.0151
Schistosoma mansoni importin beta-1 0.0028 0.0194 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0065 0.0051
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0483 0.0485
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0127 0.0503
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0483 0.0568
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.006 0.058 0.2806
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.082 0.0834
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0268 0.0263
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0065 0.0052
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.006 0.058 0.1078
Brugia malayi eukaryotic initiation factor 4A 0.0125 0.1387 0.2615
Giardia lamblia Synaptic glycoprotein SC2 0.0025 0.0154 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.1363 0.155
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0014 0.000000025206
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.006 0.058 0.2722
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0045 0.0032
Echinococcus granulosus dual specificity 0.0179 0.2062 0.2119
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0268 0.0263
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0179 0.2068 1
Onchocerca volvulus 0.0025 0.0154 0.0266
Brugia malayi MH2 domain containing protein 0.0119 0.1323 0.2494
Loa Loa (eye worm) RNA binding protein 0.0062 0.0616 0.0692
Brugia malayi TAR-binding protein 0.0062 0.0616 0.1147
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0072 0.006
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0221 0.0394
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0867 0.0854
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0127 0.0086
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.073 0.0717
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0616 0.0623
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0072 0.006
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0072 0.0006
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0068 0.0006
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0578 0.2684
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0483 0.0402
Brugia malayi jmjC domain containing protein 0.0034 0.0268 0.0483
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0178 0.0754
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0616 0.0692
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0015 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0179
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0052
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0065 0.0096
Echinococcus granulosus eukaryotic initiation factor 4A 0.0125 0.1387 0.1421
Trichomonas vaginalis set domain proteins, putative 0.023 0.2701 0.384
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0405 0.0392
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0081 0.0247
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0111 0.01
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0178 0.0161
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0137 0.0087
Brugia malayi MAP kinase sur-1 0.0103 0.1123 0.2113
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0179 0.2068 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0065 0.0051
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0065 0.0058
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0125 0.1387 0.1375
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0031 0.0017
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0068 0.0214
Schistosoma mansoni ap endonuclease 0.0018 0.0068 0.0055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0096
Giardia lamblia PHD finger protein 15 0.0059 0.0578 0.0744
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.082 0.4051
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.6926 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Brugia malayi RNA, U transporter 1 0.0081 0.0845 0.1582
Loa Loa (eye worm) hypothetical protein 0.0309 0.3672 0.4204
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0179 0.2068 0.3911
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1123 0.154
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0065 0.0052
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1123 0.154
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0125 0.1387 0.1421
Loa Loa (eye worm) hypothetical protein 0.0125 0.1387 0.1578
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0096
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0072 0.0235
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0056
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.1123 0.1111
Plasmodium vivax RNA helicase-1, putative 0.0125 0.1387 0.6964
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0052
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0045 0.0032
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0065 0.0096
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0268 0.1194
Onchocerca volvulus 0.0018 0.0065 0.0096
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0072 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Brugia malayi jmjC domain containing protein 0.0131 0.1466 0.2765
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0179 0.2062 0.9973
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.1123 0.5433
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0279 0.3302 0.4117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0142
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0268 0.0254
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0065 0.0051
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0068 0.0054
Echinococcus multilocularis cyclin dependent kinase 5 0.0172 0.1979 0.1967
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0065 0.0052
Giardia lamblia Kinase, CMGC CDK 0.0172 0.1979 0.2786
Echinococcus multilocularis cyclin dependent kinase 1 0.0172 0.1979 0.1967
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.006 0.058 0.2722
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0025 0.0154 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.2062 0.2119
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.006 0.058 0.1078
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0172 0.1979 0.2258
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0179 0.2068 0.2917
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0194 0.0797
Echinococcus multilocularis peregrin 0.0062 0.0606 0.0593
Brugia malayi Bromodomain containing protein 0.0037 0.03 0.0544
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0065 0.0096
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.006 0.058 0.0586
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0056
Echinococcus granulosus importin subunit beta 1 0.0028 0.0194 0.0186
Echinococcus multilocularis nAChR subunit 0.0018 0.0065 0.0051
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0268 0.1215
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0072 0.0066
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0025 0.0154 0.0126
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.3611 0.4133
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0179 0.2068 0.2917
Onchocerca volvulus 0.0437 0.5265 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0616 0.0623
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.1466 0.1503
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0125 0.1387 0.1924
Giardia lamblia Fructose-bisphosphate aldolase 0.0571 0.6926 1
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.006 0.058 0.0747
Trichomonas vaginalis CMGC family protein kinase 0.0172 0.1979 0.2786
Loa Loa (eye worm) hypothetical protein 0.0056 0.0538 0.0602
Entamoeba histolytica protein kinase, putative 0.0179 0.2062 0.2909
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0081 0.0258
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0368 0.1777
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.006 0.058 0.0586
Brugia malayi Pre-SET motif family protein 0.0029 0.0201 0.0356
Entamoeba histolytica cell division protein kinase 2, putative 0.0172 0.1979 0.2786
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.001
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0125 0.1387 0.1375
Schistosoma mansoni zinc finger protein 0.0019 0.0075 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0056
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2354 0.2689
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0578 0.0648
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0188 0.018
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.1123 0.1111
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0125 0.1387 0.2615
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0268 0.0263
Loa Loa (eye worm) hypothetical protein 0.0039 0.0329 0.0362
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Brugia malayi PHD-finger family protein 0.0024 0.0139 0.0238
Echinococcus multilocularis lysine specific demethylase 5A 0.0129 0.1443 0.1431
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0268 0.0254
Schistosoma mansoni fad oxidoreductase 0.006 0.058 0.0586
Entamoeba histolytica cell division protein kinase 2, putative 0.0172 0.1979 0.2786
Leishmania major importin beta-1 subunit, putative 0.0023 0.0127 0.0503
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0065 0.0096
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6926 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0368 0.0437
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.006 0.058 0.2819
Schistosoma mansoni zinc finger protein 0.0015 0.0024 0.001
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.082 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0578 0.0583
Loa Loa (eye worm) hypothetical protein 0.0175 0.2017 0.2302
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.006 0.058 0.2806
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.006 0.058 0.0651
Echinococcus granulosus lamin dm0 0.0057 0.0551 0.0555
Brugia malayi Protein kinase domain containing protein 0.0172 0.1979 0.3741
Onchocerca volvulus 0.0029 0.0201 0.0356
Echinococcus multilocularis synaptic glycoprotein sc2 0.0025 0.0154 0.014
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.006 0.058 0.2695
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Echinococcus granulosus cyclin dependent kinase 5 0.0172 0.1979 0.2033
Echinococcus granulosus geminin 0.0359 0.4303 0.4438
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0031 0.0017
Echinococcus multilocularis dna polymerase eta 0.0019 0.0072 0.0058
Echinococcus granulosus intermediate filament protein 0.0057 0.0551 0.0555
Onchocerca volvulus Putative nachr subunit 0.0018 0.0065 0.0096
Trypanosoma brucei cdc2-related kinase 3 0.0172 0.1979 0.9568
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0578 0.0583
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0137 0.0087
Brugia malayi jmjC domain containing protein 0.0034 0.0268 0.0483
Trypanosoma cruzi cdc2-related kinase 1 0.0172 0.1979 0.9563
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.006 0.058 0.2722
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0025 0.0154 0.0145
Loa Loa (eye worm) hypothetical protein 0.0042 0.0368 0.0406
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0065 0.0052
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0068 0.0102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0154 0.016
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.006 0.058 0.0586
Loa Loa (eye worm) hypothetical protein 0.0025 0.0154 0.016
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0368 0.0354
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0031 0.0036
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0025 0.0154 0.0601
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0072 0.0058
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0578 0.0565
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0271 0.0258
Loa Loa (eye worm) hypothetical protein 0.0175 0.2017 0.2302
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0201 0.0187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6926 1
Toxoplasma gondii hypothetical protein 0.0027 0.0178 0.072
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0072 0.0347
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0072 0.006
Echinococcus granulosus dna polymerase eta 0.0019 0.0072 0.006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.1123 0.538
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0268 0.0263
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.006 0.058 0.2722
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.006 0.058 0.1078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0056
Brugia malayi Probable ClpP-like protease 0.0079 0.082 0.1535
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0179 0.2068 0.2917
Brugia malayi isocitrate dehydrogenase 0.0015 0.0031 0.0033
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0368 0.0437
Echinococcus granulosus lysine specific demethylase 5A 0.0131 0.1466 0.1503
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0137 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.045
Echinococcus granulosus cyclin dependent kinase 1 0.0172 0.1979 0.2033
Loa Loa (eye worm) runx1 0.0055 0.0521 0.0583
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0111 0.0097
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0172 0.1979 0.2258
Entamoeba histolytica hypothetical protein 0.0179 0.2062 0.2909
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6926 1
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.006 0.058 0.2806
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0268 0.1295
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.1123 0.154
Brugia malayi cell division control protein 2 homolog 0.0172 0.1979 0.3741
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0179 0.2068 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0137 0.0102
Loa Loa (eye worm) hypothetical protein 0.0068 0.0689 0.0775
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.006 0.058 0.0567
Brugia malayi hypothetical protein 0.0437 0.5265 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0368 0.0437
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0179 0.2068 0.2917
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0368 0.0366
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0551 0.0617
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0268 0.0292
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0065 0.0058
Brugia malayi Uncoordinated protein 44 0.0014 0.0014 0.00000004793
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0368 0.1681
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0179 0.2062 0.9973
Loa Loa (eye worm) hypothetical protein 0.006 0.058 0.0651
Onchocerca volvulus 0.0018 0.0065 0.0096
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0867 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0616 0.0623
Echinococcus multilocularis geminin 0.0359 0.4303 0.4295
Echinococcus multilocularis cyclin dependent kinase 0.0172 0.1979 0.1967
Schistosoma mansoni hypothetical protein 0.0059 0.0578 0.0583
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0483 0.0469
Leishmania major hypothetical protein, conserved 0.0034 0.0268 0.1194
Trypanosoma brucei protein kinase, putative 0.0103 0.1123 0.5433
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0616 0.0603
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0368 0.0673
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0056
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0065 0.0052
Brugia malayi Bromodomain containing protein 0.0062 0.0606 0.1128
Onchocerca volvulus Putative fad oxidoreductase 0.006 0.058 0.1078
Brugia malayi PHD-finger family protein 0.0021 0.0104 0.0172
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0118 0.0197
Echinococcus granulosus lamin 0.0057 0.0551 0.0555
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1323 0.1505
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0221 0.0238
Onchocerca volvulus 0.0018 0.0065 0.0096
Chlamydia trachomatis D-amino acid dehydrogenase 0.006 0.058 0.6833
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0068 0.0214
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0031 0.0036
Entamoeba histolytica protein kinase, putative 0.0179 0.2062 0.2909
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0065 0.0051
Entamoeba histolytica hypothetical protein 0.0023 0.0127 0.0086
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0127 0.0086
Toxoplasma gondii hypothetical protein 0.006 0.058 0.2695
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0065 0.0052
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.006 0.058 0.2722
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.0235
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.0235
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0125 0.1387 0.6709
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0279 0.3302 0.3689
Schistosoma mansoni hypothetical protein 0.0304 0.3611 0.3722
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0068 0.0187
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0065 0.0052
Echinococcus granulosus microtubule associated protein 2 0.0792 0.9678 1
Brugia malayi intermediate filament protein 0.0057 0.0551 0.1022
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0065 0.0052
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0065 0.0096
Leishmania major hypothetical protein, conserved 0.006 0.058 0.2722
Echinococcus multilocularis snurportin 1 0.0304 0.3611 0.3602
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.006 0.058 0.2722
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0201 0.0833
Brugia malayi AF-10 protein 0.0019 0.0081 0.0128
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0127 0.0086
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.006 0.058 0.2722
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0125 0.1387 0.1421
Trichomonas vaginalis CMGC family protein kinase 0.0172 0.1979 0.2786
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0179 0.2068 1
Echinococcus granulosus phd:f box containing protein 0.0034 0.0268 0.0263
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0072 0.0347
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0065 0.0051
Brugia malayi Cation transporter family protein 0.0018 0.0065 0.0096
Loa Loa (eye worm) hypothetical protein 0.0028 0.0194 0.0206
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0137 0.0087
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0616 0.1147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6926 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0137 0.0235
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0125 0.1387 0.6671
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.082 0.0876
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0072 0.0235
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6926 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0268 0.0292
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.006 0.058 0.1078
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0014 0.000000026045
Loa Loa (eye worm) hypothetical protein 0.006 0.058 0.0651
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0179 0.2068 1
Trypanosoma cruzi cdc2-related kinase 1 0.0172 0.1979 0.9563
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0154 0.0126
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0025 0.0154 0.0126
Mycobacterium ulcerans hypothetical protein 0.0179 0.2068 0.2318
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0178 0.0754
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0065 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0111 0.01
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0025 0.0154 0.0601
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.1123 0.1148
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.082 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0065 0.0052
Echinococcus granulosus snurportin 1 0.0304 0.3611 0.3722
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0142
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0065 0.0052
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0031 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0096
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0268 0.1194
Schistosoma mansoni hypothetical protein 0.0019 0.0081 0.007
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0052
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0125 0.1387 0.1924
Onchocerca volvulus 0.0018 0.0065 0.0096
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0137 0.0102
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0072 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0065 0.0051
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0072 0.0051
Brugia malayi Synaptic glycoprotein SC2 0.0025 0.0154 0.0266
Loa Loa (eye worm) hypothetical protein 0.0028 0.0183 0.0194
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0065 0.0096
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0279 0.3302 0.3743
Mycobacterium ulcerans hypothetical protein 0.0024 0.0137 0.0087
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0081 0.0247
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0368 0.0366
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0065 0.0051
Schistosoma mansoni intermediate filament proteins 0.0057 0.0551 0.0555
Loa Loa (eye worm) hypothetical protein 0.0057 0.0551 0.0617
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0194 0.018
Leishmania major DNA polymerase eta, putative 0.0019 0.0072 0.0235
Loa Loa (eye worm) hypothetical protein 0.0079 0.082 0.0926
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0072 0.0011
Schistosoma mansoni bromodomain containing protein 0.0061 0.0599 0.0606
Echinococcus granulosus Ankyrin 0.0014 0.0015 0.0002
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0088 0.0085
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0065 0.0058
Brugia malayi PHD-finger family protein 0.0059 0.0578 0.1074
Echinococcus granulosus dna polymerase kappa 0.0019 0.0072 0.006
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0065 0.0058
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.006 0.058 0.0516
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0655 0.7976 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.1123 0.538
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0154 0.0635
Echinococcus granulosus zinc finger protein 0.0019 0.0075 0.0063
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0025 0.0154 0.0145
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.2697 0.3084
Loa Loa (eye worm) hypothetical protein 0.0169 0.1933 0.2206
Treponema pallidum fructose-bisphosphate aldolase 0.0571 0.6926 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0137 0.0555
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0066
Leishmania major eukaryotic initiation factor 4a, putative 0.0125 0.1387 0.6671
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.082 0.0796
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0616 0.0623
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.1123 0.538
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0081 0.0394
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0068 0.0061
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0179 0.2062 0.9973
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0268 0.0263
Giardia lamblia DINP protein human, muc B family 0.0019 0.0072 0.0006
Echinococcus granulosus peregrin 0.0062 0.0606 0.0613
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0179
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0062 0.016
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.006 0.058 0.0598
Brugia malayi follicle stimulating hormone receptor 0.023 0.2697 0.511
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.082 0.4051
Schistosoma mansoni fad oxidoreductase 0.006 0.058 0.0586
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0068 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0137 0.0087
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.6926 1
Onchocerca volvulus 0.0057 0.0551 0.1022
Loa Loa (eye worm) hypothetical protein 0.006 0.058 0.0651
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0025 0.0154 0.0145
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0125 0.1387 0.1924
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.082 0.0834
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0072 0.0051
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0072 0.011
Entamoeba histolytica hypothetical protein 0.0025 0.0154 0.0126
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0556 0.0561
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0551 0.0617
Echinococcus multilocularis microtubule associated protein 2 0.0792 0.9678 0.9678
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0556 0.0543
Loa Loa (eye worm) hypothetical protein 0.0117 0.1294 0.1471
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0072 0.0347
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0194 0.0936
Leishmania major hypothetical protein, conserved 0.006 0.058 0.2722
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0065 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0125 0.1387 0.6671
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Brugia malayi Bromodomain containing protein 0.0072 0.074 0.1382
Trypanosoma brucei unspecified product 0.0019 0.0072 0.0347
Mycobacterium ulcerans D-amino acid oxidase Aao 0.006 0.058 0.0598
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.006 0.058 0.0598
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Brugia malayi Protein kinase domain containing protein 0.0179 0.2062 0.39
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0045 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Onchocerca volvulus 0.0057 0.0551 0.1022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0137 0.0134
Echinococcus granulosus nAChR subunit 0.0018 0.0065 0.0052
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.082 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0291 0.0286
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0065 0.0096
Schistosoma mansoni d-amino acid oxidase 0.0715 0.8716 0.9004
Trypanosoma cruzi cdc2-related kinase 3 0.0172 0.1979 0.9563
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.005 0.0024
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0172 0.1979 0.2033
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0578 0.2807
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0065 0.0058
Schistosoma mansoni DNA polymerase eta 0.0019 0.0072 0.006
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0125 0.1387 0.1421
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0125 0.1387 0.1707
Trypanosoma brucei ISWI complex protein 0.0015 0.0024 0.0115
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0052 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0142
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0031 0.0151
Plasmodium falciparum phd finger protein, putative 0.0059 0.0578 0.2807
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0137 0.0555
Onchocerca volvulus 0.0231 0.2703 0.512
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.1466 0.1669
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0065 0.0058
Schistosoma mansoni microtubule-associated protein tau 0.0792 0.9678 1
Echinococcus multilocularis lamin dm0 0.0057 0.0551 0.0537
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0137 0.0235
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.1123 0.538
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0062 0.016
Schistosoma mansoni hypothetical protein 0.0359 0.4303 0.4438
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0031 0.0018
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0031 0.0018
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0065 0.0052
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0014 0.000000026045
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0268 0.0263
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.0235
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0065 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Plasmodium vivax importin-beta 2, putative 0.0028 0.0194 0.0834
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0268 0.0254
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.1123 0.1148
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0347
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6926 1
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0154 0.0629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.005 0.0024
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0065 0.0052
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0096
Echinococcus granulosus synaptic glycoprotein sc2 0.0025 0.0154 0.0145
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0252 0.2966 0.3055
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.082 0.1097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0368 0.0437
Echinococcus granulosus cyclin dependent kinase 0.0172 0.1979 0.2033
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0172 0.1979 0.2258
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0062 0.0039
Brugia malayi Protein kinase domain containing protein 0.0018 0.0059 0.0086
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0368 0.0366
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0201 0.0193
Brugia malayi RE18450p 0.006 0.058 0.1078
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.1123 0.5363
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0201 0.0193
Trypanosoma cruzi cdc2-related kinase 3 0.0172 0.1979 0.9563
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0065 0.0052
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0031 0.0017
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0065 0.0052
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0072 0.0347
Plasmodium vivax JmjC domain containing protein 0.0034 0.0268 0.1215
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0065 0.0096
Plasmodium vivax polyprenol reductase, putative 0.0025 0.0154 0.0629
Brugia malayi jmjC domain containing protein 0.0034 0.0268 0.0483
Loa Loa (eye worm) hypothetical protein 0.0041 0.0352 0.0388
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0058
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0065 0.0058
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0268 0.1162
Schistosoma mansoni hypothetical protein 0.0359 0.4303 0.4438
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0068 0.0187

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.187 mM Inhibitory activity against Serine/Threonine Protein phosphatase 2C (PP2C) ChEMBL. 12904075
Ki (binding) = 0.2 mM Inhibition of Human Placental alkaline Phosphatase (PLAP) ChEMBL. 12904075
Ki (binding) = 0.2 mM Inhibition of Human Placental alkaline Phosphatase (PLAP) ChEMBL. 12904075
Ki (binding) = 0.57 mM Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase) ChEMBL. 12904075
Ki (binding) = 0.57 mM Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase) ChEMBL. 12904075
NI (binding) Inhibitory activity against E. coli Alkaline Phosphatase; no inhibition ChEMBL. 12904075
NI (binding) Inhibitory activity against Tyrosine phosphatase from Yersinia (Yop protein); no inhibition ChEMBL. 12904075
NI (binding) 0 Inhibitory activity against E. coli Alkaline Phosphatase; no inhibition ChEMBL. 12904075
NI (binding) 0 Inhibitory activity against Tyrosine phosphatase from Yersinia (Yop protein); no inhibition ChEMBL. 12904075

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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