Detailed information for compound 21574

Basic information

Technical information
  • TDR Targets ID: 21574
  • Name: 4-benzhydrylidene-1-(4-phenylbutyl)piperidine
  • MW: 381.552 | Formula: C28H31N
  • H donors: 0 H acceptors: 0 LogP: 7.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)CCCCN1CCC(=C(c2ccccc2)c2ccccc2)CC1
  • InChi: 1S/C28H31N/c1-4-12-24(13-5-1)14-10-11-21-29-22-19-27(20-23-29)28(25-15-6-2-7-16-25)26-17-8-3-9-18-26/h1-9,12-13,15-18H,10-11,14,19-23H2
  • InChiKey: LEEDDCKBKUWVBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[di(phenyl)methylidene]-1-(4-phenylbutyl)piperidine
  • 4-[di(phenyl)methylene]-1-(4-phenylbutyl)piperidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 2c (5-HT2c) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus g protein coupled receptor Serotonin 2a (5-HT2a) receptor   471 aa 408 aa 21.8 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 2a (5-HT2a) receptor   471 aa 405 aa 25.4 %
Loa Loa (eye worm) hypothetical protein Serotonin 2c (5-HT2c) receptor   460 aa 417 aa 21.3 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Serotonin 2a (5-HT2a) receptor   471 aa 435 aa 23.0 %
Echinococcus granulosus g protein coupled receptor Serotonin 2a (5-HT2a) receptor   471 aa 416 aa 19.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 2c (5-HT2c) receptor   460 aa 405 aa 31.1 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 2a (5-HT2a) receptor   471 aa 422 aa 27.5 %
Echinococcus multilocularis g protein coupled receptor Serotonin 2a (5-HT2a) receptor   471 aa 417 aa 20.6 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 2c (5-HT2c) receptor   460 aa 408 aa 20.8 %
Echinococcus multilocularis g protein coupled receptor Serotonin 2a (5-HT2a) receptor   471 aa 462 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0217 0.0162
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0202 0.0525
Schistosoma mansoni biogenic amine (5HT) receptor 0.0109 0.0608 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Echinococcus granulosus cathepsin l1 0.0192 0.1211 0.1145
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.0608 0.0555
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0608 0.0537
Trypanosoma cruzi cysteine peptidase, putative 0.0105 0.0584 0.1852
Schistosoma mansoni histamine h1 receptor 0.0109 0.0608 0.0555
Echinococcus granulosus neuropeptide receptor 0.0109 0.0608 0.0537
Loa Loa (eye worm) hypothetical protein 0.0133 0.0784 0.2043
Brugia malayi cathepsin F-like cysteine proteinase 0.0046 0.0156 0.0323
Mycobacterium leprae Probable lipase LipE 0.0036 0.0086 0.0987
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0492 0.047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0584 0.4789
Trichomonas vaginalis esterase, putative 0.0036 0.0086 0.0316
Loa Loa (eye worm) hypothetical protein 0.0046 0.0156 0.0408
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0608 0.0555
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi Cathepsin L-like precursor 0.0133 0.0784 0.1686
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0098 0.0812
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1053 0.1033
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0651 0.518
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0086 0.0424
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0105 0.0584 0.1852
Brugia malayi hypothetical protein 0.0109 0.0608 0.1304
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0075 0.0825
Brugia malayi 6-phosphofructokinase 0.0114 0.0651 0.1397
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0156 0.0101
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0027 0.0024 0.0035
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0075 0.0147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0223
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Echinococcus multilocularis cathepsin L 0.0046 0.0156 0.0134
Loa Loa (eye worm) hypothetical protein 0.0046 0.0156 0.0408
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0192 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0062
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0216
Entamoeba histolytica cysteine protease, putative 0.0046 0.0156 0.1291
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0109 0.0608 0.1304
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0049 0.0343
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0046 0.0156 0.0101
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0223
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0132 0.0401
Brugia malayi Cathepsin L-like precursor 0.0192 0.1211 0.2614
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0046 0.0156 0.1236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0492 0.0438
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0192 0.1211 1
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0132 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0192 0.1211 1
Brugia malayi hypothetical protein 0.0109 0.0608 0.1304
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0109 0.0608 0.0537
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi Cathepsin L-like precursor 0.0059 0.0254 0.0534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0492 0.042
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0651 0.063
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0046 0.0156 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0584 0.4789
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0086 0.0316
Schistosoma mansoni hypothetical protein 0.0109 0.0608 0.0555
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0132 0.0401
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0651 0.1697
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0565 0.0511
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0608 0.0587
Loa Loa (eye worm) hypothetical protein 0.0044 0.014 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus multilocularis sex peptide receptor 0.0109 0.0608 0.0587
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0104 0.0861
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0132 0.1036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Plasmodium falciparum serine repeat antigen 2 0.0046 0.0156 0.1236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0202 0.0421
Onchocerca volvulus Cathepsin L homolog 0.0192 0.1211 1
Entamoeba histolytica hypothetical protein 0.0038 0.0097 0.0801
Onchocerca volvulus 0.0109 0.0608 0.4779
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0651 0.5345
Plasmodium vivax vivapain-2 0.0192 0.1211 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0049 0.0343
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Echinococcus granulosus neuropeptide s receptor 0.0109 0.0608 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0156 0.0925
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0254 0.0791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Echinococcus granulosus g protein coupled receptor 0.0109 0.0608 0.0537
Echinococcus granulosus cathepsin L cysteine proteinase 0.0192 0.1211 0.1145
Echinococcus granulosus neuropeptide receptor 0.0109 0.0608 0.0537
Echinococcus multilocularis fmrfamide receptor 0.0109 0.0608 0.0587
Trypanosoma brucei glucosidase, putative 0.0038 0.0098 0.0753
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0109 0.0608 0.0555
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0608 0.0587
Loa Loa (eye worm) cathepsin B 0.0173 0.1073 0.2797
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0156 0.1236
Brugia malayi beta-lactamase family protein 0.0036 0.0086 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0608 0.0555
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0046 0.0156 0.105
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.0608 0.0587
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0046 0.0156 0.1236
Plasmodium falciparum serine repeat antigen 7 0.0046 0.0156 0.1236
Trypanosoma cruzi cysteine peptidase, putative 0.0192 0.1211 0.3868
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0109 0.0608 0.0587
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0046 0.0156 0.1236
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.0584 0.4822
Echinococcus granulosus cathepsin L 0.0105 0.0584 0.0512
Leishmania major cathepsin L-like protease 0.0192 0.1211 1
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Giardia lamblia Cysteine protease 0.0046 0.0156 0.105
Brugia malayi Cathepsin L-like precursor 0.0133 0.0784 0.1686
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0104 0.1284
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0651 0.2067
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.0608 0.0555
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0098 0.0425
Echinococcus granulosus neuropeptide FF receptor 2 0.0109 0.0608 0.0537
Onchocerca volvulus 0.0109 0.0608 0.4779
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0457 0.312 0.3081
Mycobacterium tuberculosis Conserved protein 0.0036 0.0086 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Onchocerca volvulus 0.0192 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0202 0.0525
Onchocerca volvulus 0.0048 0.017 0.0983
Giardia lamblia Cathepsin L precursor 0.0046 0.0156 0.105
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0651 0.518
Schistosoma mansoni inositol monophosphatase 0.0039 0.0104 0.0048
Entamoeba histolytica cysteine protease, putative 0.0192 0.1211 1
Schistosoma mansoni hypothetical protein 0.017 0.1048 0.0997
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.0608 0.1586
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0049 0.0343
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0075 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.017 0.0443
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0075 0.0167
Echinococcus granulosus g-protein coupled receptor 0.0109 0.0608 0.0537
Schistosoma mansoni hypothetical protein 0.0109 0.0608 0.0555
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0217 0.0195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0492 0.042
Echinococcus granulosus cathepsin b 0.0457 0.312 0.3067
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0217 0.0195
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0104 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.0608 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Plasmodium vivax unspecified product 0.0059 0.0254 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0156 0.0925
Onchocerca volvulus Neuropeptide F receptor homolog 0.0109 0.0608 0.4779
Loa Loa (eye worm) hypothetical protein 0.0133 0.0784 0.2043
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0098 0.0753
Trypanosoma cruzi cysteine peptidase, putative 0.0192 0.1211 0.3868
Brugia malayi Inositol-1 0.0039 0.0104 0.021
Brugia malayi cathepsin F-like cysteine proteinase 0.0059 0.0254 0.0534
Plasmodium falciparum serine repeat antigen 9 0.0046 0.0156 0.1236
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0651 0.0598
Echinococcus granulosus cathepsin L 0.0046 0.0156 0.0082
Brugia malayi Melibiase family protein 0.0068 0.0319 0.0675
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Brugia malayi hypothetical protein 0.0109 0.0608 0.1304
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0319 0.0264
Schistosoma mansoni amine GPCR 0.0109 0.0608 0.0555
Loa Loa (eye worm) hypothetical protein 0.0457 0.312 0.8133
Brugia malayi G protein-coupled receptor 0.0109 0.0608 0.1304
Echinococcus multilocularis cysteine protease 0.0192 0.1211 0.1191
Trypanosoma cruzi cysteine peptidase, putative 0.0192 0.1211 0.3868
Echinococcus granulosus orexin receptor type 2 0.0109 0.0608 0.0537
Onchocerca volvulus Cathepsin L homolog 0.0192 0.1211 1
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0651 0.0598
Plasmodium falciparum cysteine proteinase falcipain 3 0.0192 0.1211 1
Leishmania major cathepsin L-like protease 0.0192 0.1211 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0109 0.0608 0.0587
Loa Loa (eye worm) hypothetical protein 0.01 0.0546 0.1424
Brugia malayi calpain 5 0.003 0.004 0.0071
Onchocerca volvulus Huntingtin homolog 0.0128 0.0749 0.5997
Leishmania major pyruvate kinase 0.0035 0.0075 0.0563
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0319 0.0264
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0086 0.003
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.1053 0.2271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192 0.1211 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0109 0.0608 0.0555
Brugia malayi cathepsin B-like cysteine proteinase 0.0457 0.312 0.676
Onchocerca volvulus 0.007 0.0332 0.2386
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0098 0.0425
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0608 0.0587
Echinococcus multilocularis somatostatin receptor 0.0109 0.0608 0.0587
Entamoeba histolytica cysteine protease, putative 0.0046 0.0156 0.1291
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0608 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0608 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0046 0.0156 0.0925
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0097 0.0022
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0132 0.0401
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0049 0.0404
Echinococcus multilocularis calpain family protein 1, d 0.0083 0.0424 0.0402
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.1053 0.0985
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0045 0.0153 0.04
Brugia malayi hypothetical protein 0.0109 0.0608 0.1304
Echinococcus granulosus calpain 7 C02 family 0.0043 0.0132 0.0057
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.0584 0.4822
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0075 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0098 0.0256
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0156 0.0925
Entamoeba histolytica hypothetical protein 0.0038 0.0097 0.0801
Echinococcus multilocularis cathepsin L cysteine protease 0.0192 0.1211 0.1191
Loa Loa (eye worm) hypothetical protein 0.0059 0.0254 0.0661
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0086 0.003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0457 0.312 0.3081
Brugia malayi Cathepsin L-like precursor 0.0192 0.1211 0.2614
Giardia lamblia Hypothetical protein 0.0046 0.0156 0.105
Echinococcus multilocularis g-protein coupled receptor 0.0109 0.0608 0.0587
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0192 0.1211 0.3158
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0046 0.0156 0.0101
Onchocerca volvulus 0.0109 0.0608 0.4779
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0086 0.0424
Onchocerca volvulus Cathepsin F homolog 0.0192 0.1211 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0086 0.0063
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0608 0.0555
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0651 0.518
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0217 0.0143
Brugia malayi Dopamine receptor protein 1 0.0109 0.0608 0.1304
Mycobacterium tuberculosis Conserved protein 0.0036 0.0086 0.0424
Echinococcus granulosus calpain A 0.0118 0.0675 0.0604
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0098 0.0425
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0192 0.1211 0.1191
Onchocerca volvulus Cathepsin L homolog 0.0046 0.0156 0.0868
Echinococcus granulosus peptide allatostatin:somatostatin 0.0109 0.0608 0.0537
Plasmodium vivax unspecified product 0.0105 0.0584 0.4789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Brugia malayi phosphofructokinase 0.0114 0.0651 0.1397
Onchocerca volvulus 0.0192 0.1211 1
Schistosoma mansoni cathepsin B (C01 family) 0.0046 0.0156 0.0101
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0492 0.1052
Entamoeba histolytica cysteine protease, putative 0.0046 0.0156 0.1291
Echinococcus multilocularis pyruvate kinase 0.0035 0.0075 0.0053
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.0608 0.0587
Schistosoma mansoni alpha-glucosidase 0.0147 0.0882 0.0831
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.0608 0.0537
Schistosoma mansoni amine GPCR 0.0109 0.0608 0.0555
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0202 0.0421
Brugia malayi Serotonin receptor 0.0664 0.4612 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0046 0.0156 0.1236
Leishmania major pyruvate kinase 0.0035 0.0075 0.0563
Schistosoma mansoni calpain (C02 family) 0.0043 0.0132 0.0077
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0075 0.0819
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0608 0.0587
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0132 0.0401
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0651 0.4294
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.1208 0.1141
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Giardia lamblia Cysteine protease 0.0046 0.0156 0.105
Echinococcus multilocularis cysteine protease 0.0192 0.1211 0.1191
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0109 0.0608 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.0584 0.4604
Schistosoma mansoni hypothetical protein 0.0294 0.1943 0.1897
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0457 0.312 0.3081
Leishmania major kinesin, putative 0.003 0.004 0.0271
Onchocerca volvulus 0.0036 0.0086 0.0255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0608 0.0587
Trypanosoma brucei cysteine peptidase C (CPC) 0.0173 0.1073 0.885
Toxoplasma gondii preprocathepsin c precursor, putative 0.0046 0.0156 0.1236
Plasmodium falciparum cysteine proteinase falcipain 1 0.0105 0.0584 0.4789
Onchocerca volvulus 0.0109 0.0608 0.4779
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192 0.1211 1
Schistosoma mansoni cathepsin F (C01 family) 0.0192 0.1211 0.1162
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0109 0.0608 0.0555
Schistosoma mansoni cathepsin F (C01 family) 0.0192 0.1211 0.1162
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0104 0.0082
Trypanosoma cruzi kinesin, putative 0.003 0.004 0.0105
Plasmodium vivax vivapain-2 0.0192 0.1211 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0086 0.0648
Echinococcus multilocularis calpain 0.0043 0.0132 0.011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0192 0.1211 0.1191
Schistosoma mansoni hypothetical protein 0.0036 0.0083 0.0027
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0049 0.0343
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Entamoeba histolytica hypothetical protein 0.0046 0.0156 0.1291
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0075 0.0563
Brugia malayi follicle stimulating hormone receptor 0.0109 0.0608 0.1304
Entamoeba histolytica cysteine proteinase 1, putative 0.0105 0.0584 0.4822
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0104 0.031
Echinococcus multilocularis hypothetical protein 0.0043 0.0132 0.011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0156 0.0101
Brugia malayi Cathepsin L-like precursor 0.0192 0.1211 0.2614
Echinococcus granulosus g protein coupled receptor 0.0109 0.0608 0.0537
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.1073 0.1022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0109 0.0608 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0156 0.0925
Chlamydia trachomatis pyruvate kinase 0.0035 0.0075 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0492 0.0438
Brugia malayi Tachykinin-like peptides receptor 99D 0.0109 0.0608 0.1304
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0109 0.0608 0.1586
Echinococcus granulosus 7TM GPCR rhodopsin 0.0109 0.0608 0.0537
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Giardia lamblia Cathepsin L-like protease 0.0046 0.0156 0.105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.0584 0.4604
Schistosoma mansoni neuropeptide receptor 0.0109 0.0608 0.0555
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1053 0.1033
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0086 0.0424
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0075 0.0218
Trypanosoma cruzi kinesin, putative 0.003 0.004 0.0105
Onchocerca volvulus 0.0109 0.0608 0.4779
Plasmodium falciparum pyruvate kinase 0.0035 0.0075 0.0563
Echinococcus multilocularis calpain A 0.0118 0.0675 0.0654
Brugia malayi beta-lactamase 0.0036 0.0086 0.0169
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0132 0.0401
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0109 0.0608 0.1304
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0608 0.0537
Trypanosoma cruzi cysteine protease, putative 0.0105 0.0584 0.1852
Giardia lamblia Cathepsin B precursor 0.0173 0.1073 1
Loa Loa (eye worm) ctsf protein 0.0192 0.1211 0.3158
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0132 0.1036
Brugia malayi RE15519p 0.0109 0.0608 0.1304
Entamoeba histolytica cysteine proteinase, putative 0.0192 0.1211 1
Giardia lamblia Cathepsin B precursor 0.0046 0.0156 0.105
Echinococcus granulosus fmrfamide receptor 0.0109 0.0608 0.0537
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.0608 0.0555
Echinococcus granulosus alpha 1A adrenergic receptor 0.0109 0.0608 0.0537
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0254 0.0661
Entamoeba histolytica cysteine protease, putative 0.0046 0.0156 0.1291
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0075 0.0563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0492 0.0438
Leishmania major cathepsin L-like protease 0.0192 0.1211 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0086 0.025
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi Dopamine receptor protein 2 0.0109 0.0608 0.1304
Echinococcus granulosus neuropeptide receptor A26 0.0109 0.0608 0.0537
Schistosoma mansoni opsin-like receptor 0.0109 0.0608 0.0555
Brugia malayi Cathepsin L-like precursor 0.0192 0.1211 0.2614
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0046 0.0156 0.0925
Brugia malayi putative neuropeptide receptor NPR1 0.0109 0.0608 0.1304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Schistosoma mansoni alpha-glucosidase 0.0147 0.0882 0.0831
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0156 0.105
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0109 0.0608 0.0587
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.017 0.0114
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0075 0.0563
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.0608 0.0537
Brugia malayi Papain family cysteine protease containing protein 0.0105 0.0584 0.1252
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Schistosoma mansoni biogenic amine (5HT) receptor 0.0109 0.0608 0.0555
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0097 0.0041
Echinococcus multilocularis tachykinin peptides receptor 99D 0.131 0.9263 0.9261
Giardia lamblia Hypothetical protein 0.0046 0.0156 0.105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0156 0.0925
Echinococcus multilocularis G protein coupled receptor 139 0.0109 0.0608 0.0587
Schistosoma mansoni cathepsin s 0.0059 0.0254 0.0199
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0098 0.0425
Schistosoma mansoni biogenic amine receptor 0.0109 0.0608 0.0555
Leishmania major cathepsin L-like protease 0.0192 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0254 0.0661
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0608 0.0587
Entamoeba histolytica hypothetical protein 0.0038 0.0097 0.0801
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.0254 0.0791
Onchocerca volvulus 0.0109 0.0608 0.4779
Schistosoma mansoni biogenic amine receptor 0.0109 0.0608 0.0555
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0075 0.0352
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0086 0.0316
Schistosoma mansoni cathepsin F (C01 family) 0.0133 0.0784 0.0732
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0132 0.1036
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0046 0.0156 0.0925
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0109 0.0608 0.0555
Loa Loa (eye worm) hypothetical protein 0.0046 0.0156 0.0408
Onchocerca volvulus 0.0192 0.1211 1
Schistosoma mansoni pyruvate kinase 0.0035 0.0075 0.0019
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0109 0.0608 0.0537
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0608 0.0555
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.017 0.0095
Loa Loa (eye worm) inositol-1 0.0039 0.0104 0.0272
Schistosoma mansoni calpain-7 (C02 family) 0.0043 0.0132 0.0077
Loa Loa (eye worm) fibroinase 0.0192 0.1211 0.3158
Schistosoma mansoni neuropeptide receptor 0.0109 0.0608 0.0555
Brugia malayi G protein-coupled receptor F59B2.13 0.0109 0.0608 0.1304
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192 0.1211 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0156 0.1236
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi hypothetical protein 0.0109 0.0608 0.1304
Brugia malayi hypothetical protein 0.0109 0.0608 0.1304
Schistosoma mansoni biogenic amine receptor 0.0109 0.0608 0.0555
Schistosoma mansoni neuropeptide receptor 0.0109 0.0608 0.0555
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0075 0.0354
Echinococcus granulosus somatostatin receptor 0.0109 0.0608 0.0537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0608 0.0587
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0046 0.0156 0.1236
Echinococcus granulosus cathepsin l1 0.0133 0.0784 0.0714
Brugia malayi ORL1-like opioid receptor 0.0109 0.0608 0.1304
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.017 0.0983
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0109 0.0608 0.0555
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.0565 0.0543
Schistosoma mansoni growth hormone secretagogue receptor 0.0109 0.0608 0.0555
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0098 0.0197
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0651 0.1697
Echinococcus granulosus cathepsin b 0.0457 0.312 0.3067
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.0608 0.1586
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Onchocerca volvulus 0.0192 0.1211 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0098 0.0291
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0086 0.0316
Brugia malayi hypothetical protein 0.0038 0.0097 0.0194
Entamoeba histolytica hypothetical protein 0.0038 0.0097 0.0801
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Toxoplasma gondii cathepsin B 0.0173 0.1073 0.885
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0086 0.0648
Giardia lamblia Cysteine protease 0.0046 0.0156 0.105
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0098 0.0812
Brugia malayi Papain family cysteine protease containing protein 0.0105 0.0584 0.1252
Loa Loa (eye worm) hypothetical protein 0.0113 0.0638 0.1664
Mycobacterium ulcerans hypothetical protein 0.0036 0.0086 0.0987
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0086 0.0316
Echinococcus multilocularis neuropeptide receptor 0.0109 0.0608 0.0587
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0075 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus granulosus cathepsin L cysteine protease 0.0105 0.0584 0.0512
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0083 0.0163
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0132 0.0401
Toxoplasma gondii cathepsin CPC1 0.0046 0.0156 0.1236
Loa Loa (eye worm) calpain family protein 1 0.0083 0.0424 0.1105
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.1053 0.2746
Schistosoma mansoni cathepsin S (C01 family) 0.0046 0.0156 0.0101
Loa Loa (eye worm) hypothetical protein 0.0046 0.0156 0.0408
Brugia malayi Cathepsin L-like cysteine proteinase 0.0133 0.0784 0.1686
Plasmodium vivax unspecified product 0.0046 0.0156 0.1236
Giardia lamblia Cathepsin L precursor 0.0046 0.0156 0.105
Echinococcus multilocularis cathepsin b 0.0457 0.312 0.3104
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0049 0.0343
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus granulosus allatostatin A receptor 0.0109 0.0608 0.0537
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0104 0.031
Brugia malayi cathepsin L-like precursor 0.0133 0.0784 0.1686
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0109 0.0608 0.1304
Toxoplasma gondii melibiase subfamily protein 0.0102 0.0565 0.4626
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0156 0.0101
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0133 0.0784 0.2493
Echinococcus granulosus 7tm_1 domain containing protein 0.0109 0.0608 0.0537
Brugia malayi mbt repeat family protein 0.0048 0.017 0.0352
Giardia lamblia Cathepsin L precursor 0.0046 0.0156 0.105
Onchocerca volvulus 0.0109 0.0608 0.4779
Entamoeba histolytica calpain large subunit domain III containing protein 0.003 0.004 0.0333
Loa Loa (eye worm) calpain 0.0043 0.0132 0.0345
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0156 0.0101
Schistosoma mansoni hypothetical protein 0.0109 0.0608 0.0555
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0651 0.5374
Echinococcus multilocularis microtubule associated protein 2 0.1412 1 1
Plasmodium falciparum serine repeat antigen 1 0.0046 0.0156 0.1236
Onchocerca volvulus 0.0109 0.0608 0.4779
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi fibroinase precursor 0.0046 0.0156 0.0323
Schistosoma mansoni microtubule-associated protein tau 0.1412 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0608 0.0587
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0082 0.0416 0.0343
Echinococcus multilocularis cathepsin L cysteine protease 0.0192 0.1211 0.1191
Echinococcus multilocularis cathepsin b 0.0457 0.312 0.3104
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0156 0.0323
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0075 0.0563
Loa Loa (eye worm) hypothetical protein 0.007 0.0332 0.0865
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0109 0.0608 0.0555
Entamoeba histolytica cysteine proteinase, putative 0.0192 0.1211 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0132 0.0401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0608 0.0555
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0608 0.0537
Schistosoma mansoni hypothetical protein 0.017 0.1048 0.0997
Giardia lamblia Cathepsin B precursor 0.0173 0.1073 1
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0132 0.1036
Entamoeba histolytica cysteine protease, putative 0.0046 0.0156 0.1291
Schistosoma mansoni amine GPCR 0.0109 0.0608 0.0555
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.0608 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0156 0.0925
Echinococcus granulosus G protein coupled receptor 139 0.0109 0.0608 0.0537
Echinococcus multilocularis neuropeptide receptor A26 0.0109 0.0608 0.0587
Giardia lamblia Cathepsin B precursor 0.0046 0.0156 0.105
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0109 0.0608 0.0537
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0118 0.0675 0.0604
Loa Loa (eye worm) hypothetical protein 0.0192 0.1211 0.3158
Leishmania major cathepsin L-like protease 0.0192 0.1211 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0046 0.0156 0.1291
Leishmania major cathepsin L-like protease 0.0192 0.1211 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192 0.1211 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0156 0.0925
Onchocerca volvulus 0.0192 0.1211 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0104 0.0476
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0109 0.0608 0.4779
Loa Loa (eye worm) calpain family protein 1 0.0113 0.0638 0.1664
Trypanosoma cruzi cysteine peptidase, putative 0.0192 0.1211 0.3868
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0075 0.0218
Schistosoma mansoni calpain C (C02 family) 0.0043 0.0132 0.0077
Brugia malayi beta-lactamase family protein 0.0036 0.0086 0.0169
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.017 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0608 0.0537
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0608 0.0587
Echinococcus multilocularis orexin receptor type 2 0.0109 0.0608 0.0587
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.017 0.0147
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0098 0.0425
Loa Loa (eye worm) cysteine protease 0.0192 0.1211 0.3158
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0082 0.0416 0.0394
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.0608 0.1586
Echinococcus multilocularis fmrfamide receptor 0.0109 0.0608 0.0587
Trypanosoma cruzi cysteine proteinase, putative 0.0105 0.0584 0.1852
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0046 0.0156 0.1236
Brugia malayi G-protein coupled receptor 0.0109 0.0608 0.1304
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0223
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0173 0.1073 0.3423
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0086 0.0648
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0608 0.0555
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.017 0.0095
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0104 0.0802
Toxoplasma gondii cathepsin CPL 0.0192 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.0784 0.2043
Giardia lamblia Cathepsin L precursor 0.0046 0.0156 0.105
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0608 0.0555
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0046 0.0156 0.1236
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0109 0.0608 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0156 0.0925
Brugia malayi cathepsin L precursor 0.0046 0.0156 0.0323
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0046 0.0156 0.1291
Schistosoma mansoni cathepsin C 0.0046 0.0156 0.0101
Echinococcus multilocularis dro:myosuppressin receptor 0.0109 0.0608 0.0587
Brugia malayi putative neuropeptide receptor 0.0109 0.0608 0.1304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi sulfakinin receptor protein 0.0556 0.3836 0.8315
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi Cathepsin L-like precursor 0.0192 0.1211 0.2614
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0492 0.1283
Brugia malayi Dopamine receptor 0.0109 0.0608 0.1304
Onchocerca volvulus 0.0109 0.0608 0.4779
Onchocerca volvulus 0.0109 0.0608 0.4779
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0046 0.0156 0.0925
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0086 0.0169
Echinococcus granulosus calpain 5 0.0043 0.0132 0.0057
Echinococcus granulosus sex peptide receptor 0.0109 0.0608 0.0537
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0109 0.0608 0.1304
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192 0.1211 1
Brugia malayi GnHR receptor homolog 0.0109 0.0608 0.1304
Schistosoma mansoni Mername-AA248 (C02 family) 0.0043 0.0132 0.0077
Plasmodium vivax vivapain-1 0.0105 0.0584 0.4789
Plasmodium vivax calpain, putative 0.0043 0.0132 0.1036
Trypanosoma brucei kinesin, putative 0.003 0.004 0.0271
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0098 0.0753
Brugia malayi Matrixin family protein 0.0054 0.0219 0.0458
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0109 0.0608 0.1304
Loa Loa (eye worm) hypothetical protein 0.0556 0.3836 1
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0156 0.0323
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0104 0.0802
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0156 0.105
Echinococcus multilocularis G-protein coupled receptor, putative 0.0109 0.0608 0.0587
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0118 0.0675 0.0654
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0046 0.0156 0.1236
Onchocerca volvulus 0.0109 0.0608 0.4779
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0156 0.0101
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi calpain family protein 1 0.0113 0.0638 0.137
Onchocerca volvulus 0.0109 0.0608 0.4779
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0651 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0109 0.0608 0.0587
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0132 0.1036
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0651 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0156 0.0101
Echinococcus multilocularis neuropeptide s receptor 0.0109 0.0608 0.0587
Loa Loa (eye worm) TYRA-2 protein 0.0109 0.0608 0.1586
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0075 0.0197
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0173 0.1073 0.885
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0156 0.0925
Entamoeba histolytica cysteine protease, putative 0.0046 0.0156 0.1291
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0086 0.0316
Brugia malayi hypothetical protein 0.0109 0.0608 0.1304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0133 0.0784 0.6321
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0086 0.0223
Echinococcus granulosus geminin 0.017 0.1048 0.098
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.0608 0.0537
Brugia malayi hypothetical protein 0.0556 0.3836 0.8315
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0104 0.0476
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192 0.1211 1
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0608 0.0537
Loa Loa (eye worm) hypothetical protein 0.0059 0.0254 0.0661
Plasmodium falciparum serine repeat antigen 5 0.0046 0.0156 0.1236
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0109 0.0608 0.1586
Onchocerca volvulus 0.0109 0.0608 0.4779
Echinococcus multilocularis cathepsin L 0.0105 0.0584 0.0562
Schistosoma mansoni hypothetical protein 0.0038 0.0097 0.0041
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0086 0.0987
Leishmania major cathepsin L-like protease 0.0192 0.1211 1
Echinococcus multilocularis Tolloid protein 1 0.0045 0.0153 0.0131
Echinococcus multilocularis calpain 5 0.0043 0.0132 0.011
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0109 0.0608 0.0537
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi hypothetical protein 0.0128 0.0749 0.161
Brugia malayi mbt repeat family protein 0.0048 0.017 0.0352
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0565 0.0511
Leishmania major cathepsin L-like protease 0.0192 0.1211 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0608 0.0555
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0651 0.5374
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0075 0.0147
Onchocerca volvulus 0.0109 0.0608 0.4779
Giardia lamblia Pyruvate kinase 0.0035 0.0075 0.0259
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus granulosus cathepsin l cysteine peptidase 0.0192 0.1211 0.1145
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0109 0.0608 0.1586
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0319 0.2319
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.0608 0.0555
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0608 0.0587
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0608 0.0555
Echinococcus granulosus biogenic amine 5HT receptor 0.0109 0.0608 0.0537
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0651 0.1697
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0098 0.0023
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0075 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0651 0.518
Loa Loa (eye worm) melatonin receptor type 1A 0.0109 0.0608 0.1586
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1485 1
Onchocerca volvulus Matrilysin homolog 0.005 0.0186 0.1124
Giardia lamblia Cathepsin B precursor 0.0046 0.0156 0.105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.0584 0.0531
Echinococcus granulosus calpain A 0.0043 0.0132 0.0057
Onchocerca volvulus 0.0099 0.0536 0.4153
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0156 0.0323
Loa Loa (eye worm) hypothetical protein 0.0046 0.0156 0.0408
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0043 0.0132 0.1036
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0651 0.058
Echinococcus multilocularis allatostatin A receptor 0.0109 0.0608 0.0587
Schistosoma mansoni alpha glucosidase 0.0038 0.0098 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0492 0.047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0217 0.0567
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0565 0.0511
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0608 0.0587
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Onchocerca volvulus 0.0192 0.1211 1
Onchocerca volvulus 0.0036 0.0086 0.0255
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Brugia malayi 6-phosphofructokinase 0.0114 0.0651 0.1397
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0086 0.0424
Loa Loa (eye worm) hypothetical protein 0.0128 0.0749 0.1952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0156 0.0925
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0173 0.1073 0.8809
Echinococcus granulosus tachykinin peptides receptor 99D 0.131 0.9263 0.9257
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0075 0.0167
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0075 0.0228
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0109 0.0608 0.0555
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0098 0.0425
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0223
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0075 0.0825
Schistosoma mansoni opsin-like receptor 0.0109 0.0608 0.0555
Schistosoma mansoni inositol monophosphatase 0.0039 0.0104 0.0048
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0156 0.1236
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Trypanosoma cruzi cruzipain precursor, putative 0.0192 0.1211 0.3868
Onchocerca volvulus 0.0192 0.1211 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0086 0.0987
Giardia lamblia Cathepsin L precursor 0.0046 0.0156 0.105
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0086 0.025
Brugia malayi Cathepsin L-like precursor 0.0192 0.1211 0.2614
Brugia malayi neuropeptide F receptor 0.0109 0.0608 0.1304
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0086 0.0987
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0156 0.0925
Mycobacterium tuberculosis Conserved protein 0.0036 0.0086 0.0424
Echinococcus granulosus cysteine protease 0.0105 0.0584 0.0512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0156 0.0925
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0109 0.0608 0.0587
Brugia malayi calpain family protein 1 0.0113 0.0638 0.137
Onchocerca volvulus 0.0133 0.0784 0.6298
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0046 0.0156 0.1236
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0608 0.0587
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0156 0.0925
Onchocerca volvulus Matrix metalloproteinase homolog 0.005 0.0186 0.1124
Echinococcus granulosus biogenic amine 5HT receptor 0.0109 0.0608 0.0537
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0156 0.0478
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0098 0.0425
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0608 0.0587
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.0584 0.0531
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0217 0.0455
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0098 0.0425
Echinococcus granulosus calpain 0.0043 0.0132 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0608 0.0537
Trypanosoma brucei antigen, putative 0.0043 0.0132 0.1036
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0651 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0132 0.0401
Echinococcus multilocularis serotonin receptor 0.0109 0.0608 0.0587
Giardia lamblia Cysteine protease 0.0046 0.0156 0.105
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0443
Schistosoma mansoni pyruvate kinase 0.0035 0.0075 0.0019
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0156 0.105
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0156 0.0323
Loa Loa (eye worm) matrixin family protein 0.005 0.0186 0.0485
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0457 0.312 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Plasmodium falciparum serine repeat antigen 3 0.0046 0.0156 0.1236
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0118 0.0675 0.0622
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.017 0.0114
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.0608 0.0537
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0156 0.0408
Giardia lamblia Cathepsin B precursor 0.0046 0.0156 0.105
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0223
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0113 0.0638 0.0585
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.0584 0.4822
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0098 0.0425
Giardia lamblia Cathepsin B precursor 0.0046 0.0156 0.105
Leishmania major cysteine peptidase A (CPA) 0.0192 0.1211 1
Brugia malayi larval opioid receptor 0.0109 0.0608 0.1304
Plasmodium falciparum serine repeat antigen 6 0.0046 0.0156 0.1236
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0109 0.0608 0.1586
Schistosoma mansoni adenoreceptor 0.0109 0.0608 0.0555
Brugia malayi Serotonin receptor 0.0109 0.0608 0.1304
Loa Loa (eye worm) AStacin protease 0.0028 0.0031 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.0584 0.4822
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0565 0.0511
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0097 0.0074
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Toxoplasma gondii cathepsin CPC2 0.0046 0.0156 0.1236
Schistosoma mansoni neuropeptide receptor 0.0109 0.0608 0.0555
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0156 0.0478
Echinococcus granulosus Tolloid protein 1 0.0045 0.0153 0.0079
Loa Loa (eye worm) calpain 5 0.003 0.004 0.0105
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.0565 0.0543
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.0608 0.0537
Brugia malayi cathepsin L-like cysteine proteinase 0.0046 0.0156 0.0323
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0086 0.0424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0608 0.0587
Schistosoma mansoni hypothetical protein 0.0109 0.0608 0.0555
Loa Loa (eye worm) hypothetical protein 0.0046 0.0156 0.0408
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.0608 0.0587
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0046 0.0156 0.1236
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0098 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0608 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0156 0.0925
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.0608 0.1586
Onchocerca volvulus 0.0109 0.0608 0.4779
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0156 0.0101
Schistosoma mansoni calpain-7 (C02 family) 0.0043 0.0132 0.0077
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0086 0.0424
Echinococcus granulosus hypothetical protein 0.0109 0.0608 0.0537
Brugia malayi Melatonin receptor type 1A 0.0109 0.0608 0.1304
Plasmodium vivax vivapain-3 0.0105 0.0584 0.4789
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0109 0.0608 0.0555
Onchocerca volvulus 0.0109 0.0608 0.4779
Echinococcus multilocularis calpain 7 (C02 family) 0.0043 0.0132 0.011
Giardia lamblia Cathepsin L precursor 0.0046 0.0156 0.105
Entamoeba histolytica protein kinase, putative 0.003 0.004 0.0333
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0049 0.0343
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0192 0.1211 0.3158
Mycobacterium ulcerans lipase LipD 0.0036 0.0086 0.0987
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0132 0.1036
Onchocerca volvulus 0.0036 0.0086 0.0255
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0046 0.0156 0.1236
Brugia malayi hypothetical protein 0.0109 0.0608 0.1304
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0086 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0192 0.1211 1
Giardia lamblia Encystation-specific protease 0.0046 0.0156 0.105
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Echinococcus granulosus dro:myosuppressin receptor 0.0109 0.0608 0.0537
Trypanosoma cruzi cysteine proteinase, putative 0.0105 0.0584 0.1852
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0217 0.0143
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0608 0.0555
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Onchocerca volvulus 0.0046 0.0156 0.0868
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0109 0.0608 0.0587
Giardia lamblia Cathepsin L-like protease 0.0046 0.0156 0.105
Loa Loa (eye worm) hypothetical protein 0.0128 0.0749 0.1952
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0086 0.0987
Brugia malayi AKH receptor 0.0109 0.0608 0.1304
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0156 0.1236
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0109 0.0608 0.1586
Plasmodium falciparum serine repeat antigen 4 0.0046 0.0156 0.1236
Loa Loa (eye worm) hypothetical protein 0.0083 0.0424 0.1105
Loa Loa (eye worm) hypothetical protein 0.0068 0.0319 0.083
Leishmania major hypothetical protein, conserved 0.0036 0.0086 0.0648
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.1208 0.1188
Brugia malayi hypothetical protein 0.0109 0.0608 0.1304
Plasmodium falciparum serine repeat antigen 8 0.0046 0.0156 0.1236
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0104 0.0802
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0132 0.1036
Brugia malayi calpain 7 0.0043 0.0132 0.0271
Brugia malayi G-protein coupled receptor 0.0109 0.0608 0.1304
Loa Loa (eye worm) matrixin family protein 0.0054 0.0219 0.057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0608 0.0555
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.0784 0.6469
Brugia malayi Hemopexin family protein 0.0032 0.0056 0.0105
Brugia malayi neuropeptide F receptor 0.0109 0.0608 0.1304
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.0608 0.0587
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0156 0.0323
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.017 0.0114
Schistosoma mansoni myosin xvIII 0.0109 0.0608 0.0555
Schistosoma mansoni amine GPCR 0.0109 0.0608 0.0555
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192 0.1211 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0046 0.0156 0.0408
Loa Loa (eye worm) beta-lactamase 0.0036 0.0086 0.0223
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0045 0.0153 0.0098
Onchocerca volvulus 0.0109 0.0608 0.4779
Giardia lamblia Cathepsin B precursor 0.0173 0.1073 1
Echinococcus granulosus g protein coupled receptor 0.0109 0.0608 0.0537
Brugia malayi Papain family cysteine protease containing protein 0.0192 0.1211 0.2614
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0457 0.312 0.3081
Schistosoma mansoni opsin-like receptor 0.0109 0.0608 0.0555
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0192 0.1211 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0192 0.1211 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0104 0.0476
Echinococcus multilocularis pyruvate kinase 0.0035 0.0075 0.0053
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0156 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0156 0.0925
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0192 0.1211 1
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.0608 0.0587
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0086 0.001
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0223
Echinococcus multilocularis serotonin receptor 0.0109 0.0608 0.0587
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.0584 0.0531
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0132 0.1036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0075 0.0197
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.1586
Entamoeba histolytica cysteine proteinase 2 0.0105 0.0584 0.4822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0133 0.0784 0.6321
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0043 0.0132 0.0401
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0104 0.0029
Entamoeba histolytica cysteine protease, putative 0.0105 0.0584 0.4822
Echinococcus multilocularis geminin 0.017 0.1048 0.1027
Schistosoma mansoni amine GPCR 0.0109 0.0608 0.0555
Echinococcus multilocularis neuropeptide receptor 0.0109 0.0608 0.0587
Onchocerca volvulus Huntingtin homolog 0.0128 0.0749 0.5997
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0651 0.5374
Loa Loa (eye worm) MBCTL1 0.0054 0.0217 0.0567
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0049 0.0343
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0118 0.0675 0.0622
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0651 0.5345
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0059 0.0254 0.0534
Schistosoma mansoni alpha-1 adrenergic receptor 0.0109 0.0608 0.0555
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0109 0.0608 0.0555
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0098 0.0076
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.0565 0.0493
Echinococcus granulosus serotonin receptor 0.0109 0.0608 0.0537
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0608 0.0537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0608 0.0555

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 20 nM Binding affinity against 5-hydroxytryptamine 2A receptor ChEMBL. 7707322
Ki (binding) = 20 nM Binding affinity against 5-hydroxytryptamine 2A receptor ChEMBL. 7707322
Ki (binding) = 220 nM Binding affinity against 5-hydroxytryptamine 2C receptor ChEMBL. 7707322
Ki (binding) = 220 nM Binding affinity against 5-hydroxytryptamine 2C receptor ChEMBL. 7707322
Selectivity (binding) = 11 Selectivity as the ratio of Ki value towards 5-hydroxytryptamine 2C receptor to that of 5-hydroxytryptamine 2A receptor ChEMBL. 7707322

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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