Detailed information for compound 224214

Basic information

Technical information
  • TDR Targets ID: 224214
  • Name: 1-(3,4-dichlorophenyl)sulfonylindole-2-carbox ylic acid
  • MW: 370.207 | Formula: C15H9Cl2NO4S
  • H donors: 1 H acceptors: 4 LogP: 4.34 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cc2c(n1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2
  • InChi: 1S/C15H9Cl2NO4S/c16-11-6-5-10(8-12(11)17)23(21,22)18-13-4-2-1-3-9(13)7-14(18)15(19)20/h1-8H,(H,19,20)
  • InChiKey: BFUXDIIDQFAZIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(3,4-dichlorophenyl)sulfonyl-2-indolecarboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0041 0.0431 0.2881
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0331 0.0462
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.002 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0105
Schistosoma mansoni smad1 5 8 and 0.0008 0.0018 0.0018
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0322 0.2516
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0322 0.2145
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0008 0.002 0.0025
Entamoeba histolytica hypothetical protein 0.0023 0.0207 0.0291
Plasmodium vivax SET domain protein, putative 0.0031 0.0303 0.3549
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0018 0.0018
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0431 0.0704
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1399 0.2294
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0431 0.0769
Brugia malayi Smad1 0.0008 0.0018 0.0042
Brugia malayi MH2 domain containing protein 0.0117 0.1399 0.3885
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0106 0.0104
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.024 0.039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0106 0.0106
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.024 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Toxoplasma gondii hypothetical protein 0.0041 0.0431 0.338
Leishmania major P-type H -ATPase, putative 0.0008 0.002 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.024 0.0237
Onchocerca volvulus 0.0056 0.0624 0.2166
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.002 0.0018
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0156 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Loa Loa (eye worm) hypothetical protein 0.0291 0.3599 0.5906
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0008 0.002 0.0029
Toxoplasma gondii cation-transporting atpase family protein 0.0008 0.002 0.0139
Toxoplasma gondii P-type ATPase4, putative 0.0008 0.002 0.0139
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0043 0.0371
Echinococcus granulosus cation transporting atpase worm 0.0008 0.002 0.0018
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0041 0.0431 0.2881
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0278 0.3436 0.5639
Schistosoma mansoni NAD dehydrogenase 0.0041 0.0431 0.0431
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0569 0.7122 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0207 0.4771
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0047 0.0517 0.0726
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0497 0.0695
Echinococcus granulosus smad 0.0008 0.0018 0.0015
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0431 0.5079
Giardia lamblia Kinase, PLK 0.0093 0.109 0.1528
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0431 0.3945
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.002 0.0025
Echinococcus granulosus cation transporting ATPase 13A3 0.0008 0.002 0.0018
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0008 0.002 0.0049
Brugia malayi RE18450p 0.0041 0.0431 0.1193
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.002 0.0018
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0008 0.002 0.002
Loa Loa (eye worm) calcium ATPase 0.0008 0.002 0.0029
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0041 0.0431 0.0704
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0124 0.1491 0.2445
Entamoeba histolytica disulphide oxidoreductase, putative 0.0007 0.0002 0.0003
Trichomonas vaginalis rotamase, putative 0.0032 0.0322 0.0449
Loa Loa (eye worm) Smad1 0.0008 0.0018 0.0025
Brugia malayi MH1 domain containing protein 0.0008 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0029
Trichomonas vaginalis helicase, putative 0.0013 0.0077 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.002 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0156 0.0428
Mycobacterium tuberculosis Probable reductase 0.0168 0.2044 0.3662
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0072 0.0828 0.0828
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.109 0.153
Loa Loa (eye worm) hypothetical protein 0.0148 0.1794 0.2941
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0207 0.1613
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0008 0.002 0.0032
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.024 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0043 0.0318
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0322 0.0452
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.015 0.0208
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.109 0.1528
Toxoplasma gondii thioredoxin reductase 0.0074 0.0849 0.6672
Loa Loa (eye worm) hypothetical protein 0.0082 0.0949 0.1555
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0008 0.002 0.0139
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.002 0.0025
Loa Loa (eye worm) glutathione reductase 0.0074 0.0849 0.139
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0072 0.0828 0.1163
Echinococcus granulosus Smad4 0.0008 0.0018 0.0015
Toxoplasma gondii P-type ATPase PMA1 0.0008 0.002 0.0139
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0008 0.002 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0105
Schistosoma mansoni hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0149 0.0147
Trypanosoma cruzi proton motive ATPase 1, putative 0.0008 0.002 0.0162
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.109 1
Leishmania major hypothetical protein, conserved 0.0041 0.0431 0.3945
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2874 0.4034
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0431 0.0704
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0497 0.0695
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0303 0.2368
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.015 0.1768
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0303 0.0301
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0156 0.0276
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0008 0.002 0.0028
Schistosoma mansoni d-amino acid oxidase 0.0488 0.6092 0.6092
Plasmodium falciparum glutathione reductase 0.0074 0.0849 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0032 0.0032
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0207 0.0367
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0041 0.0431 0.0704
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0828 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0105
Brugia malayi Na,K-ATPase alpha subunit 0.0008 0.002 0.0049
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0168 0.2044 0.3662
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0828 0.0826
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0828 0.0826
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0146 0.0401
Trypanosoma cruzi P-type H+-ATPase, putative 0.0008 0.002 0.0162
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1399 0.2294
Brugia malayi MH1 domain containing protein 0.0008 0.0018 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.109 0.1528
Leishmania major DNA polymerase eta, putative 0.0019 0.0156 0.1416
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.024 0.2183
Loa Loa (eye worm) thioredoxin reductase 0.0074 0.0849 0.139
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0207 0.0288
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0154 0.0421
Trypanosoma brucei unspecified product 0.0013 0.0082 0.0534
Plasmodium vivax cation transporting ATPase, putative 0.0008 0.002 0.0208
Treponema pallidum hypothetical protein 0.0008 0.002 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0077 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.024 0.2183
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0008 0.002 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0569 0.7122 1
Echinococcus multilocularis muscleblind protein 1 0.0291 0.3599 0.3598
Schistosoma mansoni kinase 0.0047 0.0513 0.0513
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0828 0.0826
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0331 0.0915
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.109 0.109
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0278 0.3436 0.5639
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0008 0.002 0.0032
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0168 0.2044 0.3662
Brugia malayi glutathione reductase 0.0074 0.0849 0.2354
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0704
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0074 0.0849 0.1519
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0105
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0331 0.054
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0041 0.0431 0.0429
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0008 0.002 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0077 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0569 0.7122 1
Schistosoma mansoni fad oxidoreductase 0.0041 0.0431 0.0431
Leishmania major calcium-translocating P-type ATPase 0.0008 0.002 0.0162
Trypanosoma brucei P-type H+-ATPase, putative 0.0008 0.002 0.0118
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0008 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0488 0.6092 1
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0041 0.0431 0.1494
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0303 0.0301
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0072 0.0828 0.0828
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.002 0.0049
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0008 0.002 0.0139
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0041 0.0431 0.0431
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.015 0.0148
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0008 0.002 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0041 0.0431 0.3945
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0008 0.002 0.0139
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0187 0.2281 0.4087
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.024 0.2803
Schistosoma mansoni ap endonuclease 0.0018 0.015 0.015
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.109 1
Echinococcus multilocularis expressed protein 0.0033 0.0331 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0082 0.0534
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0431 0.3945
Plasmodium falciparum glutathione reductase 0.0026 0.024 0.2822
Loa Loa (eye worm) E1-E2 ATPase 0.0008 0.002 0.0029
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0828 0.116
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.015 0.1359
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0008 0.002 0.0029
Schistosoma mansoni cpg binding protein 0.0059 0.0665 0.0665
Plasmodium vivax P-type ATPase4, putative 0.0008 0.002 0.0208
Leishmania major trypanothione reductase 0.0074 0.0849 0.7786
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.024 0.2183
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.8357 0.8356
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.024 0.039
Echinococcus multilocularis Smad4 0.0008 0.0018 0.0015
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0043 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0569 0.7122 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.109 0.3787
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0149 0.0147
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.024 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0569 0.7122 1
Schistosoma mansoni type V p-type atpase isoform 0.0008 0.002 0.002
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0007 0.0002 0.0026
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0154 0.0421
Echinococcus multilocularis cation transporting ATPase 13A3 0.0008 0.002 0.0018
Brugia malayi hypothetical protein 0.0085 0.0994 0.2758
Plasmodium vivax glutathione reductase, putative 0.0074 0.0849 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0156 0.1416
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0828 0.116
Loa Loa (eye worm) hypothetical protein 0.0072 0.0828 0.1356
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0008 0.002 0.0162
Trypanosoma brucei polo-like protein kinase 0.0093 0.109 0.7304
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0008 0.002 0.0028
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.015 0.0265
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0018 0.0015
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.024 0.066
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.015 0.6228
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0008 0.002 0.0029
Trypanosoma brucei unspecified product 0.0013 0.0082 0.0534
Plasmodium falciparum thioredoxin reductase 0.0026 0.024 0.2822
Echinococcus multilocularis cation transporting atpase worm 0.0008 0.002 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.109 0.1528
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0949 0.0947
Brugia malayi CXXC zinc finger family protein 0.0056 0.0624 0.173
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0008 0.002 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.109 0.1528
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0106 0.0104
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0156 0.1416
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0041 0.0431 0.0429
Loa Loa (eye worm) hypothetical protein 0.0031 0.0303 0.0493
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0041 0.0431 0.2881
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0207 0.1882
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0569 0.7122 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.015 0.0148
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0207 0.2437
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.015 0.0243
Plasmodium vivax calcium-transporting ATPase, putative 0.0008 0.002 0.0208
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0008 0.002 0.0029
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0156 0.0219
Treponema pallidum cation-transporting ATPase, P-type 0.0008 0.002 0.0025
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0041 0.0431 0.1193
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0828 0.7594
Echinococcus multilocularis cation transporting ATPase 13A1 0.0008 0.002 0.0018
Schistosoma mansoni copper ABC transporter ATPase 0.0008 0.002 0.002
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0041 0.0431 0.338
Schistosoma mansoni cpg binding protein 0.0059 0.0665 0.0665
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0008 0.002 0.0028
Brugia malayi Pre-SET motif family protein 0.0205 0.2517 0.6992
Trypanosoma cruzi trypanothione reductase, putative 0.0074 0.0849 0.7786
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0008 0.002 0.0032
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0949 0.0949
Leishmania major copper-transporting ATPase-like protein, putative 0.0008 0.002 0.0162
Schistosoma mansoni ATPase 0.0008 0.002 0.002
Entamoeba histolytica thioredoxin reductase, putative 0.0007 0.0002 0.0003
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0008 0.002 0.0029
Trypanosoma brucei unspecified product 0.0019 0.0156 0.1034
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0008 0.002 0.0025
Echinococcus granulosus ubiquitin specific protease 41 0.0072 0.0828 0.0826
Onchocerca volvulus 0.0148 0.1794 0.6237
Brugia malayi E1-E2 ATPase family protein 0.0008 0.002 0.0049
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0007 0.0002 0.0026
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.024 0.024
Onchocerca volvulus Putative fad oxidoreductase 0.0041 0.0431 0.1494
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0156 0.1034
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.002 0.0018
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0431 0.3945
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.015 0.1359
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0018 0.0015
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0156 0.0154
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.024 0.2822
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0168 0.2044 0.3662
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.015 0.0211
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.002 0.0025
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0008 0.002 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0303 0.0303
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.015 0.0411
Brugia malayi Pre-SET motif family protein 0.0031 0.0303 0.0835
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0156 0.0276
Loa Loa (eye worm) hypothetical protein 0.0019 0.0156 0.0253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0156 0.1416
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0322 0.2936
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0008 0.002 0.0018
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0018 0.0015
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.002 0.0025
Trypanosoma brucei cation-transporting ATPase, putative 0.0008 0.002 0.0118
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.024 0.5533
Brugia malayi E1-E2 ATPase family protein 0.0008 0.002 0.0049
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0008 0.002 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0303 0.0303
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.024 0.2803
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0008 0.002 0.0018
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0207 0.0336
Plasmodium falciparum ferrodoxin reductase-like protein 0.0007 0.0002 0.0026
Trypanosoma brucei P-type H+-ATPase, putative 0.0008 0.002 0.0118
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0156 0.0156
Schistosoma mansoni smad 0.0008 0.0018 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2517 0.413
Echinococcus granulosus cation transporting ATPase 13A1 0.0008 0.002 0.0018
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0431 0.2881
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0008 0.002 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.002 0.002
Giardia lamblia DINP protein human, muc B family 0.0019 0.0156 0.0216
Schistosoma mansoni phosphoserine phosphatase 0.0008 0.002 0.002
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0007 0.0002 0.0003
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0008 0.002 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0828 0.116
Echinococcus multilocularis smad 0.0008 0.0018 0.0015
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0043 0.0371
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.002 0.0025
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0008 0.002 0.0139
Schistosoma mansoni sulfide quinone reductase 0.0007 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0105
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0008 0.002 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0796 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0156 0.1034
Echinococcus granulosus dna polymerase eta 0.0019 0.0156 0.0154
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0156 0.0216
Schistosoma mansoni ATPase 0.0008 0.002 0.002
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.002 0.0018
Echinococcus multilocularis cpg binding protein 0.0059 0.0665 0.0663
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0704
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.024 0.2183
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0008 0.002 0.0025
Leishmania major hypothetical protein, conserved 0.0041 0.0431 0.3945
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0018 0.0025
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0008 0.002 0.0162
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.024 0.2183
Mycobacterium tuberculosis Probable oxidoreductase 0.0187 0.2281 0.4087
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0041 0.0431 0.0704
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.024 0.0333
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0029
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0156 0.0428
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.002 0.0025
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.002 0.0018
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0156 0.0154
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.024 0.0333
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0569 0.7122 1
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0008 0.002 0.0029
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0322 0.2936
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0704
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0041 0.0431 0.1494
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0828 0.7594
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0008 0.002 0.0018
Mycobacterium ulcerans lipoprotein LpqF 0.0124 0.1491 0.2445
Brugia malayi hypothetical protein 0.0008 0.002 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0077 0.0105
Echinococcus granulosus expressed protein 0.0033 0.0331 0.0329
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0008 0.002 0.0049
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0008 0.002 0.0028
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0008 0.002 0.0032
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0008 0.002 0.0018
Treponema pallidum fructose-bisphosphate aldolase 0.0569 0.7122 1
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0041 0.0431 0.0704
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0008 0.002 0.0029
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0488 0.6092 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0072 0.0828 0.0826
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0168 0.2044 0.3352
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0207 0.2417
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0008 0.002 0.0118
Leishmania major P-type H -ATPase, putative 0.0008 0.002 0.0162
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0828 0.5546
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0156 0.0253
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0008 0.002 0.0029
Echinococcus granulosus microtubule associated protein 2 0.0667 0.8357 0.8356
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0072 0.0828 0.116
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0187 0.2281 0.4087
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.8357 0.8357
Brugia malayi Thioredoxin reductase 0.0074 0.0849 0.2354
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.015 0.0208
Echinococcus granulosus cpg binding protein 0.0059 0.0665 0.0663
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0008 0.002 0.0139
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0207 0.8623
Trypanosoma brucei trypanothione reductase 0.0074 0.0849 0.5686
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.024 0.0426
Mycobacterium tuberculosis Probable dehydrogenase 0.0168 0.2044 0.3662
Plasmodium vivax copper-transporting ATPase, putative 0.0008 0.002 0.0208
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0431 0.2881
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0008 0.002 0.0234
Echinococcus multilocularis dna polymerase eta 0.0019 0.0156 0.0154
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0008 0.002 0.0029
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0624 0.1022
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0008 0.002 0.0025
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.024 0.1594
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0008 0.002 0.0029
Schistosoma mansoni rotamase 0.0033 0.0331 0.0331
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0077 0.0105
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0008 0.002 0.0029
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.002 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0077 0.0105
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.109 1
Chlamydia trachomatis metal transport ATPase 0.0008 0.002 0.041
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0106 0.0104
Echinococcus granulosus muscleblind protein 0.0291 0.3599 0.3598
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0105
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.015 0.1746
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0008 0.002 0.0018
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0156 0.1416
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0041 0.0431 0.0429
Loa Loa (eye worm) hypothetical protein 0.0085 0.0994 0.1629
Onchocerca volvulus 0.0082 0.0949 0.3297
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0008 0.002 0.0118
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0187 0.2281 0.3742
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0041 0.0431 0.1193
Toxoplasma gondii exonuclease III APE 0.0018 0.015 0.1165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0077 0.0105
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.024 0.187
Schistosoma mansoni glutamate synthase 0.0007 0.0002 0.0002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.015 0.0993
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0041 0.0431 0.0606
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0043 0.0371
Schistosoma mansoni glutamate synthase 0.0007 0.0002 0.0002
Schistosoma mansoni smad1 5 8 and 0.0008 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0029
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0569 0.7122 1
Schistosoma mansoni Smad4 0.0008 0.0018 0.0018
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0007 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0291 0.3599 0.5906
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0041 0.0431 0.3945
Schistosoma mansoni cation-transporting ATPase 0.0008 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0105
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.015 0.0208
Brugia malayi MH2 domain containing protein 0.0008 0.0018 0.0042
Onchocerca volvulus 0.0008 0.002 0.0061
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.024 0.1594
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0008 0.002 0.0018
Onchocerca volvulus 0.0031 0.0303 0.1046
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.002 0.0018
Schistosoma mansoni disulfide oxidoreductase 0.0007 0.0002 0.0002
Echinococcus granulosus copper transporting ATPase 1 0.0008 0.002 0.0018
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0156 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.109 0.1528
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0105
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0008 0.002 0.0162
Echinococcus granulosus thioredoxin glutathione reductase 0.0075 0.0861 0.0859
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0156 0.0253
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0077 0.0105
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0949 0.2633
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.024 0.2183
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0156 0.0154
Echinococcus multilocularis thioredoxin glutathione reductase 0.0075 0.0861 0.0859
Echinococcus multilocularis muscleblind protein 0.0291 0.3599 0.3598
Echinococcus multilocularis copper transporting ATPase 1 0.0008 0.002 0.0018
Treponema pallidum NADH oxidase 0.0026 0.024 0.0333
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.109 0.1088
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0207 0.0336
Chlamydia trachomatis D-amino acid dehydrogenase 0.0041 0.0431 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.024 0.2183
Trichomonas vaginalis rotamase, putative 0.0033 0.0331 0.0462
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0008 0.002 0.0018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.015 0.0243
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.1271 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0156 0.1034
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0156 0.1416
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0156 0.1416
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0447 0.5578 1
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.024 0.0333
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.024 0.2183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0569 0.7122 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0168 0.2044 0.3662
Schistosoma mansoni DNA polymerase eta 0.0019 0.0156 0.0156
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0008 0.002 0.0028
Plasmodium falciparum thioredoxin reductase 0.0074 0.0849 1
Plasmodium vivax thioredoxin reductase, putative 0.0074 0.0849 1
Trypanosoma brucei beta lactamase 0.0124 0.1491 1
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0431 0.5066
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0106 0.0104
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.024 0.1594
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0077 0.0105
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0041 0.0431 0.0704
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0008 0.002 0.0049
Leishmania major DNA polymerase kappa, putative 0.0019 0.0156 0.1416
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1432 0.1432
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0072 0.0828 0.2296
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0949 0.0947
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0008 0.002 0.0162
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.024 0.2183
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0041 0.0431 0.0431
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0008 0.002 0.0118
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0008 0.002 0.0139
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0207 0.1375
Echinococcus granulosus dna polymerase kappa 0.0019 0.0156 0.0154
Echinococcus granulosus phospholipid transporting ATPase VA 0.0008 0.002 0.0018
Trypanosoma cruzi P-type H+-ATPase, putative 0.0008 0.002 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0569 0.7122 1
Brugia malayi MH2 domain containing protein 0.0008 0.0018 0.0042
Schistosoma mansoni ap endonuclease 0.0018 0.015 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.109 0.1528
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0043 0.1701
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.024 0.2183
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0008 0.002 0.0162
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.024 0.2183
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0008 0.002 0.0029
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0278 0.3436 0.6159
Onchocerca volvulus 0.0234 0.2874 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0018 0.0015
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0047 0.0517 0.0723
Plasmodium falciparum copper-transporting ATPase 0.0008 0.002 0.0234
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0156 0.1034
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0008 0.002 0.0028
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0008 0.002 0.0028
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0007 0.0002 0.0003
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.109 0.3024
Schistosoma mansoni sulfide quinone reductase 0.0007 0.0002 0.0002
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.024 0.2183
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0431 0.3945
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0082 0.0534
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.002 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0207 0.1613
Loa Loa (eye worm) hypothetical protein 0.0085 0.0994 0.1629
Brugia malayi Muscleblind-like protein 0.0291 0.3599 1
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.024 0.187
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0007 0.0002 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0303 0.0301
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0322 0.2936
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0041 0.0431 0.3945
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.1034
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.015 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0303 0.0303
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.002 0.002
Schistosoma mansoni fad oxidoreductase 0.0041 0.0431 0.0431
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0207 0.0336
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0124 0.1491 0.2671
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0008 0.002 0.0118
Schistosoma mansoni smad1 5 8 and 0.0008 0.0018 0.0018
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0008 0.002 0.0018
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0259 0.3197 0.5731
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0041 0.0431 0.0429
Brugia malayi cDNA sequence BC016226 0.0041 0.0431 0.1193
Schistosoma mansoni eyes absent homolog 0.0085 0.0994 0.0994
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0274 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.109 0.1528
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0149 0.0241
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.024 0.2183
Brugia malayi hypothetical protein 0.0148 0.1794 0.498
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0018 0.0025
Trypanosoma cruzi cation-transporting ATPase, putative 0.0008 0.002 0.0162
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0008 0.002 0.0162
Leishmania major proton motive ATPase, putative 0.0008 0.002 0.0162
Schistosoma mansoni cpg binding protein 0.0056 0.0624 0.0624
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0569 0.7122 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0303 0.0303
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0008 0.002 0.0029
Trypanosoma cruzi copper-transporting ATPase, putative 0.0008 0.002 0.0162
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.015 0.1359
Giardia lamblia Copper-transporting P-type ATPase 0.0008 0.002 0.0025
Schistosoma mansoni glutamate synthase 0.0007 0.0002 0.0002
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0488 0.6092 1
Schistosoma mansoni atpase class VI type 11c 0.0008 0.002 0.002
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0431 0.3945
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0259 0.3197 0.5247
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.024 0.2822
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0156 0.0216
Schistosoma mansoni hypothetical protein 0.0796 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0029
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0072 0.0828 0.7594
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.109 0.1786
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.109 0.1088
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.024 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0082 0.0534
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.024 0.1594
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0008 0.002 0.0028
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0008 0.002 0.002

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.02 uM Inhibition of human C-C chemokine receptor type 2 ChEMBL. 14698169
IC50 (binding) = 1.02 uM Inhibition of human C-C chemokine receptor type 2 ChEMBL. 14698169

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.