Detailed information for compound 224783

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.906 | Formula: C22H17ClFN3O2S
  • H donors: 1 H acceptors: 3 LogP: 4.38 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Sc1ccc2c(n1)CNC(=O)N2c1c(C)cc(cc1Cl)C(=O)C
  • InChi: 1S/C22H17ClFN3O2S/c1-12-9-14(13(2)28)10-17(23)21(12)27-19-7-8-20(26-18(19)11-25-22(27)29)30-16-5-3-15(24)4-6-16/h3-10H,11H2,1-2H3,(H,25,29)
  • InChiKey: XQIXHDFCFSVXAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucose transport protein 0.001 0.0019 0.0019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0389 0.5563
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0019 0.0132
Brugia malayi phosphofructokinase 0.011 0.0753 0.251
Schistosoma mansoni DNA helicase recq1 0.0009 0.0014 0.0014
Brugia malayi Sugar transporter family protein 0.001 0.0019 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Onchocerca volvulus 0.0033 0.0192 0.055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.000000000063934
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.1063 0.1058
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0053 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.4206 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Brugia malayi hypothetical protein 0.001 0.0019 0.0047
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0005 0.0005
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0014 0.0129
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0056 0.1315
Giardia lamblia Fructose-bisphosphate aldolase 0.0585 0.4206 1
Trichomonas vaginalis myo-inositol transporter, putative 0.001 0.0019 0.0036
Schistosoma mansoni transcription factor btf3 0.0034 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0026 0.002
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.4206 1
Schistosoma mansoni cpg binding protein 0.0035 0.0206 0.0206
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0014 0.0009
Mycobacterium ulcerans integral membrane transport protein 0.001 0.0019 0.0069
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0014 0.0009
Loa Loa (eye worm) sugar transporter 0.001 0.0019 0.0047
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0153 0.1063 1
Trypanosoma cruzi hexose transporter, putative 0.001 0.0019 0.0132
Trypanosoma cruzi hexose transporter 0.001 0.0019 0.0132
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Echinococcus multilocularis lamin 0.0027 0.0142 0.0137
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0166 0.0121
Trypanosoma brucei glucose transporter, putative 0.001 0.0019 0.0132
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0019 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0117 0.1613
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0398 0.0393
Brugia malayi Pre-SET motif family protein 0.0417 0.2985 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0398 0.3715
Onchocerca volvulus 0.001 0.0019 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0753 0.1782
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0016 0.0103
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0286 0.2029 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.02 0.1836
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0142 0.046
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0117 0.29
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0753 0.178
Plasmodium vivax sugar transporter, putative 0.001 0.0019 0.0364
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0005 0.0005
Schistosoma mansoni glucose transporter 0.001 0.0019 0.0019
Leishmania major cytochrome p450-like protein 0.0012 0.004 0.0328
Loa Loa (eye worm) hypothetical protein 0.0082 0.0545 0.181
Trichomonas vaginalis set domain proteins, putative 0.0474 0.3403 0.809
Trypanosoma brucei sugar transporter, putative 0.001 0.0019 0.0132
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0753 0.0748
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0016 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.000000000063934
Schistosoma mansoni sugar transporter 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0029
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.02 1
Brugia malayi CXXC zinc finger family protein 0.0033 0.0192 0.0628
Echinococcus multilocularis geminin 0.0167 0.1164 0.1159
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0033 0.0265
Onchocerca volvulus 0.001 0.0019 0.0041
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0753 0.707
Onchocerca volvulus 0.001 0.0019 0.0041
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Echinococcus granulosus geminin 0.0167 0.1164 0.1159
Entamoeba histolytica hypothetical protein 0.0023 0.0117 0.0265
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0033 0.0265
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0476 0.3413 0.3409
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0166 0.2334
Giardia lamblia Kinase, CMGC MAPK 0.0102 0.0695 0.1642
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0695 0.6521
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0019 0.0036
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.02 0.1836
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0014 0.0009
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0166 0.0386
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0117 0.1613
Onchocerca volvulus 0.001 0.0019 0.0041
Echinococcus multilocularis solute carrier family 22 0.001 0.0019 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0753 0.1782
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0026 0.0026
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0003
Leishmania major hypothetical protein, conserved 0.0025 0.013 0.1175
Loa Loa (eye worm) RecQ helicase 0.0022 0.0107 0.0341
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0055 0.0713
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.02 0.5062
Echinococcus granulosus synaptic vesicle 2 protein 0.001 0.0019 0.0014
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0005 0.0005
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.02 0.0465
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.1063 0.1058
Loa Loa (eye worm) sugar transporter 0.001 0.0019 0.0047
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.0785 0.2616
Trypanosoma cruzi sugar transporter, putative 0.001 0.0019 0.0132
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0014 0.003
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0753 0.3696
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Brugia malayi 6-phosphofructokinase 0.011 0.0753 0.251
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0192 0.0628
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Onchocerca volvulus 0.0027 0.0142 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0019 0.0036
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0102 0.0695 0.6521
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.02 0.0465
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.004 0.0328
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0753 0.1782
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0019 0.0047
Schistosoma mansoni hypothetical protein 0.0011 0.003 0.003
Schistosoma mansoni hypothetical protein 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.006 0.0389 0.1288
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0004 0.000000000063934
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0026 0.002
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0019 0.0014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0026 0.002
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.013 0.324
Plasmodium vivax hexose transporter 0.001 0.0019 0.0364
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0389 0.0389
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0033 0.007
Onchocerca volvulus 0.001 0.0019 0.0041
Brugia malayi hypothetical protein 0.001 0.0019 0.0047
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0785 0.3852
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0102 0.0695 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Echinococcus multilocularis mitogen activated protein kinase 3 0.0102 0.0695 0.069
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0286 0.2029 1
Onchocerca volvulus 0.006 0.0389 0.1129
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0695 0.1644
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0053 0.0159
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0389 0.0384
Leishmania major glucose transporter, lmgt3 0.001 0.0019 0.0132
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.0728 0.2427
Onchocerca volvulus 0.0082 0.0545 0.1587
Echinococcus granulosus mitogen activated protein kinase 14 0.0153 0.1063 0.1058
Echinococcus granulosus mitogen activated protein kinase 3 0.0102 0.0695 0.069
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0695 0.0695
Trypanosoma cruzi glucose transporter, putative 0.001 0.0019 0.0132
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0389 0.0384
Onchocerca volvulus Putative transporter 0.001 0.0019 0.0041
Echinococcus granulosus solute carrier family 22 0.001 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0753 0.251
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.4206 1
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0153 0.1063 0.355
Brugia malayi major facilitator superfamily protein 0.001 0.0019 0.0047
Schistosoma mansoni carbonyl reductase 0.0008 0.0005 0.0005
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.046
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.013 0.1175
Echinococcus multilocularis solute carrier family 22 0.001 0.0019 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.004 0.0117
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0166 0.2334
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0426 0.6097
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0003
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.001 0.0019 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0695 0.1644
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0166 1
Toxoplasma gondii transporter, major facilitator family protein 0.001 0.0019 0.0203
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.004 0.0328
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.001 0.0019 0.0014
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0014 0.0009
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trypanosoma brucei glucose transporter, putative 0.001 0.0019 0.0132
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0368 0.0363
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Leishmania major glucose transporter, lmgt1 0.001 0.0019 0.0132
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0398 0.1942
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0042 0.0037
Brugia malayi Cytochrome P450 family protein 0.0012 0.004 0.0117
Trichomonas vaginalis glucose transporter, putative 0.001 0.0019 0.0036
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Echinococcus multilocularis lamin dm0 0.0027 0.0142 0.0137
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0166 0.4195
Echinococcus granulosus lamin 0.0027 0.0142 0.0137
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.0005 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.4206 1
Trypanosoma cruzi hexose transporter, putative 0.001 0.0019 0.0132
Loa Loa (eye worm) ICD-1 protein 0.0034 0.02 0.0652
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.000000000063934
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0117 0.1052
Toxoplasma gondii facilitative glucose transporter GT1 0.001 0.0019 0.0203
Onchocerca volvulus 0.001 0.0019 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.004 0.0117
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.013 0.1175
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Schistosoma mansoni lamin 0.0027 0.0142 0.0142
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0389 0.0384
Onchocerca volvulus 0.001 0.0019 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.4206 1
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0695 0.1644
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Brugia malayi major facilitator superfamily protein 0.001 0.0019 0.0047
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0014 0.003
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0019 0.0047
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0153 0.1063 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0166 0.0383
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0166 0.0386
Loa Loa (eye worm) histone methyltransferase 0.0013 0.004 0.0117
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Echinococcus granulosus solute carrier family 22 0.001 0.0019 0.0014
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0166 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0166 0.0386
Leishmania major hypothetical protein, conserved 0.0009 0.0016 0.0103
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0166 0.8287
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trypanosoma brucei glucose transporter, putative 0.001 0.0019 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0019 0.0036
Schistosoma mansoni hypothetical protein 0.0167 0.1164 0.1164
Schistosoma mansoni glucose transport protein 0.001 0.0019 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.013 0.6401
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0545 0.054
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.001 0.0019 0.0069
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0166 0.0386
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.001 0.0019 0.0069
Trichomonas vaginalis glucose transporter, putative 0.001 0.0019 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0389 0.0389
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.02 0.1836
Brugia malayi 6-phosphofructokinase 0.011 0.0753 0.251
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0753 0.0753
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0545 0.054
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0166 0.0386
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0014 0.0129
Echinococcus granulosus Sugar transporter ERD6 protein 0.001 0.0019 0.0014
Giardia lamblia Sugar-proton symporter 0.001 0.0019 0.0033
Echinococcus multilocularis Sugar transporter ERD6 protein 0.001 0.0019 0.0014
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0019 0.0014
Schistosoma mansoni sugar transporter 0.001 0.0019 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.004 0.0035
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.003 0.0025
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0019 0.0014
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Brugia malayi beta-NAC-like protein 0.0034 0.02 0.0652
Echinococcus granulosus transcription factor btf3 0.0034 0.02 0.0194
Echinococcus granulosus solute carrier family 22 0.001 0.0019 0.0014
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0033 0.0265
Echinococcus multilocularis synaptic vesicle 2 protein 0.001 0.0019 0.0014
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0117 0.5729
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.003 0.0025
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0398 0.0393
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0019 0.0047
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0286 0.2029 1
Schistosoma mansoni cpg binding protein 0.0035 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0481 0.0481
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Schistosoma mansoni sugar transporter 0.001 0.0019 0.0019
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.0785 0.3852
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0107 0.0102
Schistosoma mansoni microtubule-associated protein tau 0.1381 1 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0166 0.4195
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0107 0.0244
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.0785 0.0785
Giardia lamblia Hexose transporter 0.001 0.0019 0.0033
Echinococcus multilocularis cpg binding protein 0.0035 0.0206 0.0201
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Schistosoma mansoni lamin 0.0027 0.0142 0.0142
Trypanosoma brucei glucose transporter, putative 0.001 0.0019 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0389 0.0389
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.013 0.6401
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Echinococcus granulosus mitogen activated protein kinase 0.0102 0.0695 0.069
Leishmania major glucose transporter/membrane transporter D2, putative 0.001 0.0019 0.0132
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Echinococcus multilocularis transcription factor btf3 0.0034 0.02 0.0194
Schistosoma mansoni hypothetical protein 0.0167 0.1164 0.1164
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Echinococcus multilocularis mitogen activated protein kinase 0.0102 0.0695 0.069
Onchocerca volvulus 0.001 0.0019 0.0041
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0088 0.4243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.4206 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0785 0.3852
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.001 0.0019 0.072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.003
Onchocerca volvulus 0.001 0.0019 0.0041
Echinococcus multilocularis solute carrier family 22 0.001 0.0019 0.0014
Brugia malayi Cytochrome P450 family protein 0.0012 0.004 0.0117
Brugia malayi hypothetical protein 0.0025 0.013 0.0417
Onchocerca volvulus 0.001 0.0019 0.0041
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0398 0.0398
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.013 0.1802
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Echinococcus granulosus cpg binding protein 0.0035 0.0206 0.0201
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0004 0.000000000063934
Trypanosoma brucei glucose transporter, putative 0.001 0.0019 0.0132
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0107 0.0341
Schistosoma mansoni cpg binding protein 0.0033 0.0192 0.0192
Trypanosoma cruzi hexose transporter, putative 0.001 0.0019 0.0132
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0695 0.6521
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0039 0.0114
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0112
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0117 0.055
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.001 0.0019 0.0069
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0117 0.055
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0014 0.003
Echinococcus granulosus lamin dm0 0.0027 0.0142 0.0137
Trypanosoma brucei cytochrome P450, putative 0.0012 0.004 0.0328
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0166 0.0386
Echinococcus granulosus solute carrier family 22 0.001 0.0019 0.0014
Schistosoma mansoni carbonyl reductase 0.0008 0.0005 0.0005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.2985 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0753 0.178
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.0005 0.0003
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.02 0.1836
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0753 0.1782
Brugia malayi P38 map kinase family protein 2 0.0153 0.1063 0.355
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0753 0.178
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0112
Onchocerca volvulus 0.0027 0.0142 0.0403
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0398 0.1942
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.004 0.0172
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Loa Loa (eye worm) CYP4Cod1 0.0012 0.004 0.0117
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0166 0.0383
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0142 0.046
Schistosoma mansoni sugar transporter 0.001 0.0019 0.0019
Toxoplasma gondii sugar transporter ST1 0.001 0.0019 0.0203
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trypanosoma brucei glucose transporter 2A 0.001 0.0019 0.0132
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.02 0.0462
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.0005 0.0003
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.1063 1
Onchocerca volvulus 0.0474 0.3403 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0398 0.1942
Echinococcus multilocularis solute carrier family 22 0.001 0.0019 0.0014
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Echinococcus granulosus intermediate filament protein 0.0027 0.0142 0.0137
Brugia malayi Pre-SET motif family protein 0.006 0.0389 0.1288
Schistosoma mansoni intermediate filament proteins 0.0027 0.0142 0.0142
Leishmania major glucose transporter, lmgt2 0.001 0.0019 0.0132
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0019 0.0036
Echinococcus multilocularis musashi 0.0027 0.0142 0.0137
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0033 0.0067
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0107 0.0244
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.1063 0.1058
Brugia malayi Sugar transporter family protein 0.001 0.0019 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0695 0.1644
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0019 0.0132
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0166 0.2334
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0019 0.0014
Schistosoma mansoni DNA helicase recq5 0.0009 0.0014 0.0014
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0545 0.181
Brugia malayi intermediate filament protein 0.0027 0.0142 0.046
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0014 0.0458
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.013 0.1175
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0102 0.0695 0.6521
Echinococcus granulosus dnaJ subfamily B 0.0476 0.3413 0.3409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.4206 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0102 0.0695 0.2315
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0042 0.0037
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.4206 1
Toxoplasma gondii sugar transporter ST2 0.001 0.0019 0.0203
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0142 0.046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0234
Onchocerca volvulus 0.001 0.0019 0.0041
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0166 0.8287
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0124
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0102 0.0695 0.6521
Trichomonas vaginalis sugar transport protein, putative 0.001 0.0019 0.0036
Leishmania major hypothetical protein, conserved 0.001 0.0019 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.4206 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0019 0.0014
Echinococcus multilocularis microtubule associated protein 2 0.1381 1 1
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0753 0.251
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0139 0.0448
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.000000000063934
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0117 0.1052
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0753 0.3696
Onchocerca volvulus 0.001 0.0019 0.0041
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0753 0.0753
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0019 0.0047
Plasmodium falciparum hexose transporter 0.001 0.0019 0.072
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0019 0.0036
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Trypanosoma cruzi hexose transporter, putative 0.001 0.0019 0.0132
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0753 0.0748
Onchocerca volvulus 0.001 0.0019 0.0041
Mycobacterium ulcerans sugar transporter 0.001 0.0019 0.0069
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0166 0.0386
Loa Loa (eye worm) POT family protein 0.008 0.0534 0.1774
Toxoplasma gondii sugar transporter ST3 0.001 0.0019 0.0203
Plasmodium vivax SET domain protein, putative 0.006 0.0389 1
Entamoeba histolytica hypothetical protein 0.0034 0.02 0.0462
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0785 0.078
Brugia malayi POT family protein 0.008 0.0534 0.1774
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.02 0.0465
Leishmania major myo-inositol/proton symporter (MIT) 0.001 0.0019 0.0132
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0014 0.0021
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0005 0.0005
Treponema pallidum fructose-bisphosphate aldolase 0.0585 0.4206 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0753 0.707
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0003
Loa Loa (eye worm) phosphofructokinase 0.011 0.0753 0.251
Loa Loa (eye worm) hypothetical protein 0.0025 0.013 0.0417
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0019 0.0047
Schistosoma mansoni hypothetical protein 0.0476 0.3413 0.3413
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0398 0.1942
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0398 0.5696
Trypanosoma brucei glucose transporter, putative 0.001 0.0019 0.0132
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0753 0.1556
Brugia malayi Sugar transporter family protein 0.001 0.0019 0.0047
Onchocerca volvulus 0.001 0.0019 0.0041
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0117 1
Echinococcus granulosus Solute carrier family 22 5 0.1019 0.7369 0.7368
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.1063 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.001 0.0019 0.0132
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Onchocerca volvulus 0.001 0.0019 0.0041
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.001 0.0019 0.0069
Trypanosoma brucei glucose transporter 1E 0.001 0.0019 0.0132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.004 0.0035
Schistosoma mansoni glucose transport protein 0.001 0.0019 0.0019
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.1063 0.1058
Onchocerca volvulus 0.001 0.0019 0.0041
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0785 0.078
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0102 0.0695 0.6521
Brugia malayi hypothetical protein 0.001 0.0019 0.0047
Brugia malayi hypothetical protein 0.0016 0.0066 0.0202
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0019 0.0014
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0117 0.055
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0074 0.0074
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Trichomonas vaginalis glucose transporter, putative 0.001 0.0019 0.0036
Trypanosoma brucei protein kinase, putative 0.0102 0.0695 0.6521
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.000000000063934
Schistosoma mansoni carbonyl reductase 0.0008 0.0005 0.0005
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0047
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0753 0.707
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0545 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0019 0.0036
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0117 0.055
Trypanosoma brucei glucose transporter, putative 0.001 0.0019 0.0132
Trypanosoma brucei glucose transporter, putative 0.001 0.0019 0.0132
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.001 0.0019 0.1256
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0019 0.0036
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.0785 0.7368
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0019 0.0014
Trichomonas vaginalis sugar transporter, putative 0.001 0.0019 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.4206 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0153 0.1063 0.1058
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.0005 0.0003
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0003
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0753 0.3696
Echinococcus granulosus bloom syndrome protein 0.0022 0.0107 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0389 0.0389
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0398 0.0398
Brugia malayi MAP kinase sur-1 0.0102 0.0695 0.2315
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0102 0.0695 0.6521
Toxoplasma gondii NAC domain-containing protein 0.0034 0.02 0.2816
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.000000000063934

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 47 nM Inhibitory activity against Mitogen-activated protein kinase p38 alpha ChEMBL. 14592489
IC50 (binding) = 47 nM Inhibitory activity against Mitogen-activated protein kinase p38 alpha ChEMBL. 14592489
Inhibition (binding) = 80 % Inhibition of Mitogen-activated protein kinase p38 beta at 300 nM ChEMBL. 14592489
Inhibition (binding) = 80 % Inhibition of Mitogen-activated protein kinase p38 beta at 300 nM ChEMBL. 14592489

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.