Detailed information for compound 249610

Basic information

Technical information
  • TDR Targets ID: 249610
  • Name: (E)-3-(2,4-dimethoxyphenyl)-1-phenylprop-2-en -1-one
  • MW: 268.307 | Formula: C17H16O3
  • H donors: 0 H acceptors: 1 LogP: 3.63 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1/C=C/C(=O)c1ccccc1
  • InChi: 1S/C17H16O3/c1-19-15-10-8-14(17(12-15)20-2)9-11-16(18)13-6-4-3-5-7-13/h3-12H,1-2H3/b11-9+
  • InChiKey: WIVAGKMXNMVMFC-PKNBQFBNSA-N  


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Synonyms

  • (E)-3-(2,4-dimethoxyphenyl)-1-phenyl-prop-2-en-1-one
  • (E)-3-(2,4-dimethoxyphenyl)-1-phenyl-2-propen-1-one
  • 3-(2,4-dimethoxyphenyl)-1-phenylprop-2-en-1-one
  • 3-(2,4-dimethoxyphenyl)-1-phenyl-prop-2-en-1-one
  • 2,4-Dimethoxychalcone
  • AIDS-115353
  • AIDS115353
  • ZINC04293591
  • STOCK5S-33175
  • 3-(2,4-dimethoxyphenyl)-1-phenyl-2-propen-1-one
  • MLS000680272
  • SMR000268417

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Rattus norvegicus Arachidonate 5-lipoxygenase Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Brugia malayi Trypsin family protein 0.0184875 0.269824 0.435491
Echinococcus granulosus rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.017806 0.257089 0.279685
Echinococcus granulosus biogenic amine 5HT receptor 0.017806 0.257089 0.279685
Schistosoma mansoni adenoreceptor 0.017806 0.257089 0.4263
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.017806 0.257089 0.4263
Schistosoma mansoni alpha-1 adrenergic receptor 0.017806 0.257089 0.4263
Echinococcus granulosus biogenic amine 5HT receptor 0.017806 0.257089 0.279685
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Trypanosoma cruzi cysteine peptidase, putative 0.0155853 0.215595 0.273767
Brugia malayi G protein-coupled receptor 0.017806 0.257089 0.41481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Brugia malayi G-protein coupled receptor 0.017806 0.257089 0.41481
Echinococcus multilocularis sex peptide receptor 0.017806 0.257089 0.279685
Echinococcus granulosus g protein coupled receptor 0.017806 0.257089 0.279685
Loa Loa (eye worm) bone morphogenetic protein 1b 0.00889805 0.0906366 0.0891178
Toxoplasma gondii cathepsin CPL 0.0155853 0.215595 0.284175
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.017806 0.257089 0.255849
Onchocerca volvulus 0.0315563 0.514026 0.551659
Plasmodium vivax vivapain-1 0.00867131 0.0863999 0.0996528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017806 0.257089 0.4263
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.017806 0.257089 0.255849
Loa Loa (eye worm) hypothetical protein 0.0184875 0.269824 0.268604
Schistosoma mansoni cathepsin D (A01 family) 0.0147467 0.199924 0.33089
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.017806 0.257089 0.279685
Schistosoma mansoni amine GPCR 0.017806 0.257089 0.4263
Echinococcus multilocularis alpha 1A adrenergic receptor 0.017806 0.257089 0.279685
Brugia malayi cathepsin F-like cysteine proteinase 0.00471412 0.0124562 0.0175212
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Brugia malayi Cathepsin L-like precursor 0.00471412 0.0124562 0.0175212
Loa Loa (eye worm) hypothetical protein 0.00862362 0.0855088 0.0839814
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Brugia malayi Cathepsin L-like precursor 0.0155853 0.215595 0.347422
Echinococcus multilocularis allatostatin A receptor 0.017806 0.257089 0.279685
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.00500152 0.0178266 0.0176942
Trypanosoma cruzi cruzipain precursor, putative 0.0155853 0.215595 0.273767
Brugia malayi Papain family cysteine protease containing protein 0.00867131 0.0863999 0.137607
Entamoeba histolytica cysteine proteinase, putative 0.0108712 0.127507 0.588237
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.017806 0.257089 0.4263
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.017806 0.257089 0.269784
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.017806 0.257089 0.279685
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155853 0.215595 0.87627
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00500152 0.0178266 0.0269698
Schistosoma mansoni amine GPCR 0.017806 0.257089 0.4263
Loa Loa (eye worm) hypothetical protein 0.00471412 0.0124562 0.0108068
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Echinococcus granulosus dro:myosuppressin receptor 0.017806 0.257089 0.279685
Echinococcus granulosus neuropeptide receptor 0.017806 0.257089 0.279685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Schistosoma mansoni serine/threonine protein kinase 0.00706158 0.0563206 0.0912164
Onchocerca volvulus 0.0155853 0.215595 0.224262
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.017806 0.257089 0.4263
Echinococcus granulosus cysteine protease 0.00867131 0.0863999 0.0927814
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus granulosus rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Loa Loa (eye worm) neuropeptide F receptor 0.017806 0.257089 0.255849
Onchocerca volvulus 0.017806 0.257089 0.269784
Echinococcus granulosus Protein kinase C brain isozyme 0.00706158 0.0563206 0.0598449
Brugia malayi Cathepsin L-like precursor 0.0108712 0.127507 0.204367
Loa Loa (eye worm) hypothetical protein 0.0046455 0.0111741 0.00952252
Echinococcus multilocularis neuropeptide Y receptor 0.017806 0.257089 0.279685
Mycobacterium tuberculosis Hypothetical protein 0.0150122 0.204885 0.114754
Plasmodium falciparum cysteine proteinase falcipain 1 0.00867131 0.0863999 0.0930889
Echinococcus granulosus orexin receptor type 2 0.017806 0.257089 0.279685
Onchocerca volvulus Cathepsin F homolog 0.0155853 0.215595 0.224262
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.017806 0.257089 0.41481
Echinococcus granulosus neuropeptide FF receptor 2 0.017806 0.257089 0.279685
Brugia malayi GnHR receptor homolog 0.017806 0.257089 0.41481
Giardia lamblia Cathepsin B precursor 0.0172145 0.246037 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.017806 0.257089 0.279685
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0444239 0.754469 1
Schistosoma mansoni biogenic amine receptor 0.017806 0.257089 0.4263
Echinococcus granulosus serotonin receptor 0.017806 0.257089 0.279685
Loa Loa (eye worm) melatonin receptor type 1A 0.017806 0.257089 0.255849
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.017806 0.257089 0.255849
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Schistosoma mansoni neuropeptide F-like receptor 0.017806 0.257089 0.4263
Echinococcus granulosus G protein coupled receptor 139 0.017806 0.257089 0.279685
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus granulosus 7TM GPCR rhodopsin 0.017806 0.257089 0.279685
Echinococcus granulosus rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.00487046 0.0153776 0.0137331
Schistosoma mansoni neuropeptide F-like receptor 0.017806 0.257089 0.4263
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.017806 0.257089 0.279685
Mycobacterium ulcerans thymidylate synthase 0.0315563 0.514026 1
Brugia malayi cathepsin L-like precursor 0.0108712 0.127507 0.204367
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Entamoeba histolytica cysteine proteinase, putative 0.00867131 0.0863999 0.39608
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0444239 0.754469 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Onchocerca volvulus 0.0155853 0.215595 0.224262
Loa Loa (eye worm) hypothetical protein 0.0370898 0.617424 0.616785
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0046455 0.0111741 0.00952252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017806 0.257089 0.4263
Onchocerca volvulus 0.017806 0.257089 0.269784
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Brugia malayi hypothetical protein 0.017806 0.257089 0.41481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Echinococcus multilocularis laminin 0.00487046 0.0153776 0.0150125
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0444239 0.754469 1
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus multilocularis rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Onchocerca volvulus Cathepsin L homolog 0.0155853 0.215595 0.224262
Schistosoma mansoni peptide (allatostatin)-like receptor 0.017806 0.257089 0.4263
Echinococcus multilocularis neuropeptide receptor 0.017806 0.257089 0.279685
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Brugia malayi hypothetical protein 0.017806 0.257089 0.41481
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0362016 0.600828 1
Brugia malayi Serotonin receptor 0.017806 0.257089 0.41481
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0155853 0.215595 0.268472
Entamoeba histolytica cysteine proteinase, putative 0.00867131 0.0863999 0.39608
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Echinococcus granulosus neuropeptide Y receptor 0.017806 0.257089 0.279685
Echinococcus multilocularis cathepsin L 0.00867131 0.0863999 0.0927814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Onchocerca volvulus Neuropeptide F receptor homolog 0.017806 0.257089 0.269784
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017806 0.257089 0.4263
Echinococcus granulosus tm gpcr rhodopsin 0.017806 0.257089 0.279685
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.017806 0.257089 0.279685
Loa Loa (eye worm) follicle stimulating hormone receptor 0.017806 0.257089 0.255849
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0172145 0.246037 0.0564923
Onchocerca volvulus 0.017806 0.257089 0.269784
Echinococcus multilocularis neuropeptides capa receptor 0.017806 0.257089 0.279685
Echinococcus granulosus cathepsin L 0.00867131 0.0863999 0.0927814
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017806 0.257089 0.4263
Schistosoma mansoni biogenic amine receptor 0.017806 0.257089 0.4263
Brugia malayi hypothetical protein 0.0370898 0.617424 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0150122 0.204885 0.259334
Echinococcus multilocularis neuropeptide s receptor 0.017806 0.257089 0.279685
Schistosoma mansoni neuropeptide receptor 0.017806 0.257089 0.4263
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0315563 0.514026 1
Brugia malayi Dopamine receptor 0.017806 0.257089 0.41481
Brugia malayi Cathepsin L-like cysteine proteinase 0.0108712 0.127507 0.204367
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.017806 0.257089 0.4263
Schistosoma mansoni atypical protein kinase C 0.00706158 0.0563206 0.0912164
Echinococcus multilocularis serotonin receptor 0.017806 0.257089 0.279685
Echinococcus granulosus cathepsin b 0.0362016 0.600828 0.656076
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Giardia lamblia Cathepsin B precursor 0.0172145 0.246037 0.5
Onchocerca volvulus 0.0108712 0.127507 0.127625
Trypanosoma cruzi cysteine proteinase, putative 0.00867131 0.0863999 0.0996528
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.017806 0.257089 0.279685
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0315563 0.514026 0.855128
Loa Loa (eye worm) hypothetical protein 0.00471412 0.0124562 0.0108068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Entamoeba histolytica cysteine protease, putative 0.0155853 0.215595 1
Schistosoma mansoni opsin-like receptor 0.017806 0.257089 0.4263
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00867131 0.0863999 0.141419
Loa Loa (eye worm) hypothetical protein 0.00500152 0.0178266 0.0161862
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155853 0.215595 0.87627
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus multilocularis rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.017806 0.257089 0.41481
Echinococcus multilocularis neuropeptide Y receptor 0.017806 0.257089 0.279685
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.017806 0.257089 0.279685
Echinococcus granulosus neuropeptides capa receptor 0.017806 0.257089 0.279685
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.018884 0.277233 0.459919
Loa Loa (eye worm) hypothetical protein 0.0155853 0.215595 0.214285
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00867131 0.0863999 0.141419
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0362016 0.600828 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.017806 0.257089 0.279685
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.017806 0.257089 0.4263
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.00889805 0.0906366 0.14849
Loa Loa (eye worm) hypothetical protein 0.0534271 0.922701 0.922572
Schistosoma mansoni cathepsin F (C01 family) 0.0155853 0.215595 0.357045
Entamoeba histolytica cysteine proteinase 2 0.00867131 0.0863999 0.39608
Schistosoma mansoni hypothetical protein 0.017806 0.257089 0.4263
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0362016 0.600828 0.79294
Brugia malayi sulfakinin receptor protein 0.0370898 0.617424 1
Schistosoma mansoni myosin xvIII 0.017806 0.257089 0.4263
Echinococcus multilocularis orexin receptor type 2 0.017806 0.257089 0.279685
Loa Loa (eye worm) TYRA-2 protein 0.017806 0.257089 0.255849
Brugia malayi Papain family cysteine protease containing protein 0.00867131 0.0863999 0.137607
Echinococcus multilocularis rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.00706158 0.0563206 0.0547445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Echinococcus multilocularis thymidylate synthase 0.0315563 0.514026 0.561029
Schistosoma mansoni opsin-like receptor 0.017806 0.257089 0.4263
Brugia malayi hypothetical protein 0.017806 0.257089 0.41481
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.017806 0.257089 0.279685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00867131 0.0863999 0.351166
Echinococcus granulosus rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Echinococcus multilocularis fibrillin 1 0.00487046 0.0153776 0.0150125
Brugia malayi Cathepsin L-like precursor 0.0155853 0.215595 0.347422
Loa Loa (eye worm) cysteine protease 0.0155853 0.215595 0.214285
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.00867131 0.0863999 0.0996528
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus multilocularis dro:myosuppressin receptor 0.017806 0.257089 0.279685
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0444239 0.754469 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Echinococcus granulosus allatostatin A receptor 0.017806 0.257089 0.279685
Echinococcus multilocularis neuropeptides capa receptor 0.017806 0.257089 0.279685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155853 0.215595 0.87627
Brugia malayi Calcium binding EGF domain containing protein 0.00487046 0.0153776 0.0222655
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.00500152 0.0178266 0.0176942
Echinococcus multilocularis g protein coupled receptor 0.017806 0.257089 0.279685
Schistosoma mansoni amine GPCR 0.017806 0.257089 0.4263
Echinococcus multilocularis rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Echinococcus granulosus rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Brugia malayi Serotonin/octopamine receptor family protein 7 0.017806 0.257089 0.41481
Brugia malayi Cathepsin L-like precursor 0.0108712 0.127507 0.204367
Onchocerca volvulus 0.017806 0.257089 0.269784
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0155853 0.215595 0.87627
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172145 0.246037 1
Brugia malayi hypothetical protein 0.0150122 0.204885 0.33003
Echinococcus granulosus dihydrofolate reductase 0.0128676 0.164812 0.178642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155853 0.215595 0.87627
Trypanosoma cruzi cysteine protease, putative 0.00867131 0.0863999 0.0996528
Trypanosoma cruzi cysteine peptidase, putative 0.0155853 0.215595 0.273767
Brugia malayi neuropeptide F receptor 0.017806 0.257089 0.41481
Onchocerca volvulus 0.017806 0.257089 0.269784
Echinococcus multilocularis cathepsin b 0.0362016 0.600828 0.656076
Brugia malayi Cathepsin L-like precursor 0.0155853 0.215595 0.347422
Chlamydia trachomatis dihydrofolate reductase 0.0128676 0.164812 0.5
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Brugia malayi Dihydrofolate reductase 0.0128676 0.164812 0.264949
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Loa Loa (eye worm) hypothetical protein 0.0534271 0.922701 0.922572
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0155853 0.215595 0.268472
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0155853 0.215595 0.234249
Brugia malayi Papain family cysteine protease containing protein 0.0155853 0.215595 0.347422
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Schistosoma mansoni hypothetical protein 0.017806 0.257089 0.4263
Schistosoma mansoni cathepsin s 0.00471412 0.0124562 0.0180065
Echinococcus multilocularis rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Loa Loa (eye worm) cathepsin B 0.0172145 0.246037 0.244778
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.017806 0.257089 0.279685
Echinococcus multilocularis protein kinase c epsilon type 0.00706158 0.0563206 0.0598449
Schistosoma mansoni opsin-like receptor 0.017806 0.257089 0.4263
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.017806 0.257089 0.279685
Toxoplasma gondii cathepsin B 0.0172145 0.246037 0.324614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Echinococcus multilocularis serotonin receptor 0.017806 0.257089 0.279685
Echinococcus granulosus cathepsin l1 0.0108712 0.127507 0.137794
Loa Loa (eye worm) hypothetical protein 0.0108712 0.127507 0.12605
Echinococcus granulosus neuropeptide s receptor 0.017806 0.257089 0.279685
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0184875 0.269824 0.447553
Onchocerca volvulus 0.017806 0.257089 0.269784
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0155853 0.215595 0.214285
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.017806 0.257089 0.279685
Brugia malayi Dopamine receptor protein 2 0.017806 0.257089 0.41481
Loa Loa (eye worm) hypothetical protein 0.0184875 0.269824 0.268604
Echinococcus granulosus alpha 1A adrenergic receptor 0.017806 0.257089 0.279685
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus granulosus peptide allatostatin:somatostatin 0.017806 0.257089 0.279685
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.017806 0.257089 0.255849
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Schistosoma mansoni serine/threonine protein kinase 0.00706158 0.0563206 0.0912164
Schistosoma mansoni cathepsin D (A01 family) 0.0147467 0.199924 0.33089
Echinococcus multilocularis rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Schistosoma mansoni biogenic amine receptor 0.017806 0.257089 0.4263
Schistosoma mansoni neuropeptide receptor 0.017806 0.257089 0.4263
Schistosoma mansoni biogenic amine (5HT) receptor 0.017806 0.257089 0.4263
Entamoeba histolytica cysteine proteinase, putative 0.0155853 0.215595 1
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Schistosoma mansoni egf-like domain protein 0.0046455 0.0111741 0.0158666
Giardia lamblia Cathepsin B precursor 0.0172145 0.246037 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Brugia malayi Serotonin receptor 0.017806 0.257089 0.41481
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.017806 0.257089 0.279685
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.017806 0.257089 0.279685
Brugia malayi follicle stimulating hormone receptor 0.017806 0.257089 0.41481
Loa Loa (eye worm) hypothetical protein 0.0108712 0.127507 0.12605
Echinococcus granulosus thymidylate synthase 0.0315563 0.514026 0.561029
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0444239 0.754469 1
Echinococcus granulosus protein kinase c epsilon type 0.00706158 0.0563206 0.0598449
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Echinococcus granulosus tm gpcr rhodopsin 0.017806 0.257089 0.279685
Echinococcus granulosus cathepsin L cysteine protease 0.00867131 0.0863999 0.0927814
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus granulosus neuropeptide receptor 0.017806 0.257089 0.279685
Brugia malayi hypothetical protein 0.017806 0.257089 0.41481
Brugia malayi G-protein coupled receptor 0.017806 0.257089 0.41481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017806 0.257089 0.4263
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.00500152 0.0178266 0.0724551
Brugia malayi dihydrofolate reductase family protein 0.0128676 0.164812 0.264949
Onchocerca volvulus 0.017806 0.257089 0.269784
Brugia malayi hypothetical protein 0.017806 0.257089 0.41481
Echinococcus multilocularis cathepsin L cysteine protease 0.0155853 0.215595 0.234249
Brugia malayi larval opioid receptor 0.017806 0.257089 0.41481
Onchocerca volvulus 0.017806 0.257089 0.269784
Loa Loa (eye worm) hypothetical protein 0.0575638 1 1
Brugia malayi ORL1-like opioid receptor 0.017806 0.257089 0.41481
Echinococcus granulosus g-protein coupled receptor 0.017806 0.257089 0.279685
Loa Loa (eye worm) fibroinase 0.0155853 0.215595 0.214285
Loa Loa (eye worm) hypothetical protein 0.0563519 0.977355 0.977317
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0046455 0.0111741 0.015439
Brugia malayi Dopamine receptor protein 1 0.017806 0.257089 0.41481
Plasmodium vivax unspecified product 0.00867131 0.0863999 0.0996528
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0362016 0.600828 1
Onchocerca volvulus 0.0155853 0.215595 0.224262
Plasmodium vivax plasmepsin IV, putative 0.00500152 0.0178266 0.00723763
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.017806 0.257089 0.41481
Onchocerca volvulus 0.017806 0.257089 0.269784
Brugia malayi cathepsin B-like cysteine proteinase 0.0362016 0.600828 0.973048
Loa Loa (eye worm) hypothetical protein 0.0046455 0.0111741 0.00952252
Echinococcus multilocularis G protein coupled receptor 139 0.017806 0.257089 0.279685
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017806 0.257089 0.4263
Echinococcus granulosus g protein coupled receptor 0.017806 0.257089 0.279685
Echinococcus granulosus sex peptide receptor 0.017806 0.257089 0.279685
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Brugia malayi gonadotropin-releasing hormone receptor 2 0.017806 0.257089 0.41481
Echinococcus granulosus cathepsin L cysteine proteinase 0.0155853 0.215595 0.234249
Echinococcus granulosus rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Echinococcus granulosus cathepsin l cysteine peptidase 0.0155853 0.215595 0.234249
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Brugia malayi hypothetical protein 0.017806 0.257089 0.41481
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Schistosoma mansoni biogenic amine (5HT) receptor 0.017806 0.257089 0.4263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00867131 0.0863999 0.112556
Echinococcus granulosus cathepsin b 0.0362016 0.600828 0.656076
Schistosoma mansoni neuropeptide receptor 0.017806 0.257089 0.4263
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017806 0.257089 0.4263
Schistosoma mansoni serine/threonine protein kinase 0.00706158 0.0563206 0.0912164
Brugia malayi thymidylate synthase 0.0315563 0.514026 0.83208
Schistosoma mansoni hypothetical protein 0.017806 0.257089 0.4263
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Onchocerca volvulus 0.017806 0.257089 0.269784
Echinococcus granulosus laminin 0.00487046 0.0153776 0.0150125
Echinococcus multilocularis g protein coupled receptor 0.017806 0.257089 0.279685
Plasmodium vivax aspartyl proteinase, putative 0.00500152 0.0178266 0.00723763
Schistosoma mansoni amine GPCR 0.017806 0.257089 0.4263
Echinococcus granulosus 7tm_1 domain containing protein 0.017806 0.257089 0.279685
Schistosoma mansoni amine GPCR 0.017806 0.257089 0.4263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Echinococcus multilocularis biogenic amine (5HT) receptor 0.017806 0.257089 0.279685
Plasmodium vivax vivapain-2 0.0155853 0.215595 0.273767
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Brugia malayi hypothetical protein 0.017806 0.257089 0.41481
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Schistosoma mansoni cathepsin F (C01 family) 0.0108712 0.127507 0.210027
Echinococcus granulosus tachykinin peptides receptor 99D 0.0530105 0.914916 1
Onchocerca volvulus 0.0160848 0.224927 0.2345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus multilocularis g protein coupled receptor 0.017806 0.257089 0.279685
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0530105 0.914916 1
Brugia malayi putative neuropeptide receptor 0.017806 0.257089 0.41481
Onchocerca volvulus 0.0155853 0.215595 0.224262
Echinococcus multilocularis g-protein coupled receptor 0.017806 0.257089 0.279685
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0172145 0.246037 0.314793
Entamoeba histolytica cysteine proteinase, putative 0.0155853 0.215595 1
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Onchocerca volvulus 0.017806 0.257089 0.269784
Echinococcus granulosus cathepsin l1 0.0155853 0.215595 0.234249
Echinococcus granulosus neuropeptide Y receptor 0.017806 0.257089 0.279685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Onchocerca volvulus 0.0534271 0.922701 1
Schistosoma mansoni hypothetical protein 0.017806 0.257089 0.4263
Onchocerca volvulus 0.0155853 0.215595 0.224262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108712 0.127507 0.518245
Loa Loa (eye worm) thymidylate synthase 0.0315563 0.514026 0.513215
Echinococcus multilocularis neuropeptide receptor A26 0.017806 0.257089 0.279685
Trypanosoma cruzi cysteine peptidase, putative 0.00867131 0.0863999 0.0996528
Brugia malayi Cathepsin L-like precursor 0.0155853 0.215595 0.347422
Brugia malayi Melatonin receptor type 1A 0.017806 0.257089 0.41481
Echinococcus multilocularis dihydrofolate reductase 0.0128676 0.164812 0.178642
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Echinococcus multilocularis cysteine protease 0.0155853 0.215595 0.234249
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00471412 0.0124562 0.0108068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Brugia malayi Tachykinin-like peptides receptor 99D 0.017806 0.257089 0.41481
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.017806 0.257089 0.4263
Echinococcus multilocularis cathepsin L cysteine protease 0.0155853 0.215595 0.234249
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Echinococcus multilocularis Protein kinase C, brain isozyme 0.00706158 0.0563206 0.0598449
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Brugia malayi Fibulin-1 precursor 0.00487046 0.0153776 0.0222655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00867131 0.0863999 0.351166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Brugia malayi AKH receptor 0.017806 0.257089 0.41481
Plasmodium falciparum cysteine proteinase falcipain 3 0.0155853 0.215595 0.268472
Schistosoma mansoni dihydrofolate reductase 0.0128676 0.164812 0.272288
Schistosoma mansoni biogenic amine (dopamine) receptor 0.017806 0.257089 0.4263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Onchocerca volvulus Cathepsin L homolog 0.0155853 0.215595 0.224262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155853 0.215595 0.87627
Loa Loa (eye worm) hypothetical protein 0.00526696 0.0227866 0.0211544
Toxoplasma gondii calcium binding egf domain-containing protein 0.00487046 0.0153776 0.0182122
Schistosoma mansoni neuropeptide f receptor 76f 0.017806 0.257089 0.4263
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155853 0.215595 0.87627
Schistosoma mansoni growth hormone secretagogue receptor 0.017806 0.257089 0.4263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Echinococcus granulosus protein kinase c iota type 0.00706158 0.0563206 0.0598449
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Echinococcus multilocularis fmrfamide receptor 0.017806 0.257089 0.279685
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.017806 0.257089 0.279685
Echinococcus multilocularis cathepsin b 0.0362016 0.600828 0.656076
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0155853 0.215595 0.234249
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172145 0.246037 0.407854
Loa Loa (eye worm) G-protein coupled receptor 0.017806 0.257089 0.255849
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0362016 0.600828 1
Echinococcus granulosus rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Echinococcus granulosus neuropeptides capa receptor 0.017806 0.257089 0.279685
Trichomonas vaginalis conserved hypothetical protein 0.0150122 0.204885 0.832742
Loa Loa (eye worm) hypothetical protein 0.0534271 0.922701 0.922572
Entamoeba histolytica cysteine proteinase, putative 0.00867131 0.0863999 0.39608
Echinococcus granulosus Tolloid protein 1 0.00889805 0.0906366 0.0974206
Onchocerca volvulus 0.017806 0.257089 0.269784
Echinococcus multilocularis fmrfamide receptor 0.017806 0.257089 0.279685
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.017806 0.257089 0.4263
Brugia malayi neuropeptide F receptor 0.017806 0.257089 0.41481
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Trypanosoma cruzi cysteine peptidase, putative 0.0155853 0.215595 0.273767
Loa Loa (eye worm) G-protein coupled receptor 0.017806 0.257089 0.255849
Trypanosoma cruzi cysteine peptidase, putative 0.0155853 0.215595 0.273767
Echinococcus granulosus hypothetical protein 0.017806 0.257089 0.279685
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.00500152 0.0178266 0.0214655
Toxoplasma gondii calcium binding egf domain-containing protein 0.00487046 0.0153776 0.0182122
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Trypanosoma brucei cysteine peptidase C (CPC) 0.0172145 0.246037 0.324614
Onchocerca volvulus 0.017806 0.257089 0.269784
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.017806 0.257089 0.279685
Loa Loa (eye worm) hypothetical protein 0.00471412 0.0124562 0.0108068
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Loa Loa (eye worm) hypothetical protein 0.00487046 0.0153776 0.0137331
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0155853 0.215595 0.214285
Schistosoma mansoni biogenic amine (dopamine) receptor 0.017806 0.257089 0.4263
Echinococcus granulosus somatostatin receptor 0.017806 0.257089 0.279685
Toxoplasma gondii aspartyl protease ASP1 0.00500152 0.0178266 0.0214655
Echinococcus multilocularis neuropeptide receptor 0.017806 0.257089 0.279685
Onchocerca volvulus 0.017806 0.257089 0.269784
Plasmodium vivax vivapain-3 0.00867131 0.0863999 0.0996528
Brugia malayi hypothetical protein 0.017806 0.257089 0.41481
Echinococcus multilocularis G-protein coupled receptor, putative 0.017806 0.257089 0.279685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00867131 0.0863999 0.112556
Brugia malayi Cathepsin L-like precursor 0.0155853 0.215595 0.347422
Echinococcus multilocularis protein kinase c iota type 0.00706158 0.0563206 0.0598449
Echinococcus multilocularis somatostatin receptor 0.017806 0.257089 0.279685
Loa Loa (eye worm) hypothetical protein 0.0108712 0.127507 0.12605
Onchocerca volvulus 0.0155853 0.215595 0.224262
Loa Loa (eye worm) aspartic protease BmAsp-2 0.00500152 0.0178266 0.0161862
Schistosoma mansoni neuropeptide receptor 0.017806 0.257089 0.4263
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.017806 0.257089 0.279685
Entamoeba histolytica cysteine proteinase 1, putative 0.00867131 0.0863999 0.39608
Plasmodium vivax vivapain-2 0.0155853 0.215595 0.273767
Onchocerca volvulus 0.017806 0.257089 0.269784
Loa Loa (eye worm) neuropeptide F receptor 0.017806 0.257089 0.255849
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Onchocerca volvulus 0.0155853 0.215595 0.224262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155853 0.215595 0.87627
Brugia malayi Cathepsin L-like precursor 0.0155853 0.215595 0.347422
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0108712 0.127507 0.155053
Echinococcus granulosus fmrfamide receptor 0.017806 0.257089 0.279685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155853 0.215595 0.87627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Onchocerca volvulus 0.017806 0.257089 0.269784
Loa Loa (eye worm) hypothetical protein 0.0362016 0.600828 0.600161
Loa Loa (eye worm) ctsf protein 0.0155853 0.215595 0.214285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155853 0.215595 0.87627
Brugia malayi G protein-coupled receptor F59B2.13 0.017806 0.257089 0.41481
Schistosoma mansoni histamine h1 receptor 0.017806 0.257089 0.4263
Echinococcus multilocularis rhodopsin orphan GPCR 0.017806 0.257089 0.279685
Brugia malayi putative neuropeptide receptor NPR1 0.017806 0.257089 0.41481
Echinococcus granulosus g protein coupled receptor 0.017806 0.257089 0.279685
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0444239 0.754469 1
Entamoeba histolytica cysteine protease, putative 0.00867131 0.0863999 0.39608
Echinococcus granulosus neuropeptide receptor A26 0.017806 0.257089 0.279685
Onchocerca volvulus 0.0184875 0.269824 0.283754
Schistosoma mansoni cathepsin F (C01 family) 0.0155853 0.215595 0.357045
Onchocerca volvulus 0.017806 0.257089 0.269784
Entamoeba histolytica cysteine proteinase, putative 0.00867131 0.0863999 0.39608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155853 0.215595 0.87627
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0155853 0.215595 0.87627
Echinococcus multilocularis Tolloid protein 1 0.00889805 0.0906366 0.0974206
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.00471412 0.0124562 0.0175212
Trichomonas vaginalis AGC family protein kinase 0.00413674 0.00166741 0.00677706
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0315563 0.514026 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00867131 0.0863999 0.141419
Brugia malayi RE15519p 0.017806 0.257089 0.41481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108712 0.127507 0.518245
Trypanosoma cruzi cysteine proteinase, putative 0.00867131 0.0863999 0.0996528
Brugia malayi hypothetical protein 0.017806 0.257089 0.41481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155853 0.215595 0.284175
Schistosoma mansoni biogenic amine (dopamine) receptor 0.017806 0.257089 0.4263
Echinococcus multilocularis cysteine protease 0.0155853 0.215595 0.234249
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.017806 0.257089 0.4263
Loa Loa (eye worm) dihydrofolate reductase 0.0128676 0.164812 0.163417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017806 0.257089 0.4263
Loa Loa (eye worm) hypothetical protein 0.017806 0.257089 0.255849
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017806 0.257089 0.4263
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.017806 0.257089 0.4263
Brugia malayi protein kinase C II. 0.00706158 0.0563206 0.0887579
Echinococcus granulosus thyrotropin releasing hormone receptor 0.017806 0.257089 0.279685

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 932.406 um PUBCHEM_BIOASSAY: Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response. (Class of assay: confirmatory) [Related pubchem assays: 1239 ] ChEMBL. No reference
GI (functional) = 91 % Growth inhibition of human Calu1 cells at 10 uM after 24 hrs by propidium iodide assay ChEMBL. 20064725
GI (functional) = 92 % Growth inhibition of human H460 cells at 10 uM after 24 hrs by propidium iodide assay ChEMBL. 20064725
GI (functional) = 93 % Growth inhibition of human ACHN cells at 10 uM after 24 hrs by propidium iodide assay ChEMBL. 20064725
GI (functional) = 94 % Growth inhibition of human PANC1 cells at 10 uM after 24 hrs by propidium iodide assay ChEMBL. 20064725
GI (functional) = 95 % Growth inhibition of human HCT116 cells at 10 uM after 24 hrs by propidium iodide assay ChEMBL. 20064725
IC50 (binding) = 3.429 Inhibition of Saccharomyces cerevisiae chitin synthase ChEMBL. No reference
IC50 (functional) = 0.65 uM Inhibition of Leishmania donovani amastigotes in human monocyte-derived macrophages ChEMBL. 17112640
IC50 (functional) = 0.65 uM Inhibition of Leishmania donovani amastigotes in human monocyte-derived macrophages ChEMBL. 17112640
IC50 (functional) = 4 uM Growth inhibition of Leishmania major promastigotes assessed as [3H]thymidine incorporation ChEMBL. 17112640
IC50 (functional) = 4 uM Growth inhibition of Leishmania major promastigotes assessed as [3H]thymidine incorporation ChEMBL. 17112640
IC50 (binding) = 10 uM Inhibition of 5-lipoxygenase in rat RBL1 cells ChEMBL. No reference
IC50 (functional) = 15 uM Tested in vitro for anti-leishmanial activity against Leishmania donovani ChEMBL. 9822551
IC50 (functional) = 15 uM Tested in vitro for anti-leishmanial activity against Leishmania donovani ChEMBL. 9822551
IC50 (functional) = 48 uM Inhibitory activity against phytohemmagglutinin A-induced proliferation of human lymphocytes ChEMBL. 9822551
IC50 (functional) = 130.65 uM Cytotoxicity against Homo sapiens (human) HT-29 cells after 72 hr by MTT assay ChEMBL. No reference
Inhibition (functional) = 98 % Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha release at 10 uM preincubated for 30 mins before LPS challenge by ELISA ChEMBL. 20064725
Inhibition (functional) = 100 % Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL6 release at 10 uM preincubated for 30 mins before LPS challenge by ELISA ChEMBL. 20064725
Potency (functional) 0.2593 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3934 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1961 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Leishmania major ChEMBL23 17112640
Homo sapiens ChEMBL23
Leishmania donovani ChEMBL23 17112640

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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