Detailed information for compound 271449

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 500.387 | Formula: C27H23Cl2F2N2O-
  • H donors: 0 H acceptors: 1 LogP: 6.87 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(cc1)n1c2CCN(Cc2c2c1ccc(c2)F)CCCC(=O)c1ccc(cc1)Cl.[Cl-]
  • InChi: 1S/C27H23ClF2N2O.ClH/c28-19-5-3-18(4-6-19)27(33)2-1-14-31-15-13-26-24(17-31)23-16-21(30)9-12-25(23)32(26)22-10-7-20(29)8-11-22;/h3-12,16H,1-2,13-15,17H2;1H/p-1
  • InChiKey: FUNVKRUKIQCFPC-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi protein C24B5.3 0.0013 0.0006 0.001
Echinococcus multilocularis GPCR, family 2 0.005 0.0213 0.0213
Brugia malayi Protein kinase domain containing protein 0.0018 0.0033 0.0054
Toxoplasma gondii subtilisin SUB2 0.0055 0.0245 0.8435
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0083 0.0048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0223 0.0679
Schistosoma mansoni hypothetical protein 0.005 0.0213 0.0347
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0821 0.1336
Echinococcus granulosus Furin 1 0.0353 0.1928 0.3137
Schistosoma mansoni hypothetical protein 0.0089 0.0438 0.0712
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0078 0.0375 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.002 0.002
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0055 0.0245 0.6366
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0245 0.0747
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.0138 0.3692
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.002 0.0033
Schistosoma mansoni smad1 5 8 and 0.0018 0.0033 0.0054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0031 0.005
Loa Loa (eye worm) proprotein convertase 2 0.0353 0.1928 0.3137
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0033 0.1141
Brugia malayi endoprotease bli-4 precursor 0.1099 0.6146 1
Leishmania major hypothetical protein, conserved 0.0018 0.0033 0.0883
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0196 0.0319
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0196 0.6744
Brugia malayi ecdysteroid receptor 0.0033 0.0119 0.0194
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0119 0.0194
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Echinococcus granulosus Smad4 0.0018 0.0033 0.0054
Schistosoma mansoni tyrosine kinase 0.0182 0.0963 0.1566
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0138 0.3396
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Echinococcus granulosus smad 0.0018 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Echinococcus granulosus epidermal growth factor receptor 0.0182 0.0963 0.1566
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0027 0.0082 0.2192
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.002 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0083 0.0048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0821 0.1336
Echinococcus granulosus cpg binding protein 0.0034 0.0125 0.0203
Echinococcus multilocularis survival motor neuron protein 1 0.0519 0.2868 0.2868
Loa Loa (eye worm) hypothetical protein 0.0269 0.1453 0.2365
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0213 0.0213
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0128 0.3117
Loa Loa (eye worm) hypothetical protein 0.0519 0.2868 0.4666
Schistosoma mansoni ran 0.0047 0.0196 0.0319
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0128 0.0128
Echinococcus multilocularis protein dispatched 1 0.0106 0.0531 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0245 0.0747
Loa Loa (eye worm) hypothetical protein 0.0555 0.307 0.4994
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.021 0.0342
Trichomonas vaginalis hypothetical protein 0.025 0.1347 0.4109
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0219 0.1174 0.1909
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0027 0.0082 0.0712
Onchocerca volvulus 0.0048 0.0201 0.0669
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0073
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.002 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0031 0.005
Loa Loa (eye worm) transcription factor SMAD2 0.0262 0.1415 0.2301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0119 0.0194
Loa Loa (eye worm) hypothetical protein 0.016 0.0839 0.1366
Trypanosoma brucei heat shock protein 84, putative 0.0015 0.0017 0.0447
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0096 0.2225
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0119 0.0194
Loa Loa (eye worm) hypothetical protein 0.005 0.0213 0.0347
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Schistosoma mansoni hypothetical protein 0.0107 0.054 0.0878
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0031 0.005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0196 0.4996
Brugia malayi nuclear receptor NHR-67 0.0016 0.002 0.0033
Plasmodium vivax subtilisin-like serine protease, putative 0.0055 0.0245 0.8435
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0375 0.1144
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0009 0.0014
Echinococcus granulosus dnaJ subfamily B 0.0459 0.2527 0.4111
Loa Loa (eye worm) patched family protein 0.0013 0.0006 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.029 0.774
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Echinococcus granulosus glycoprotein Antigen 5 0.0049 0.0212 0.0345
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0353 0.1928 0.3137
Brugia malayi neuroendocrine convertase 1 precursor 0.0989 0.5526 0.899
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.1431 0.8025 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0015 0.0017 0.0036
Echinococcus multilocularis Furin 1 0.0353 0.1928 0.1928
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0119 0.0194
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0298 0.1616 0.4929
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0128 0.0209
Echinococcus multilocularis heat shock protein 90 0.0036 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0135
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0119 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0119 0.0194
Brugia malayi intermediate filament protein 0.0059 0.0267 0.0435
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Schistosoma mansoni hypothetical protein 0.0089 0.0438 0.0712
Brugia malayi nuclear receptor NHR-88 0.0016 0.002 0.0033
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0096 0.0093
Schistosoma mansoni nuclear receptor 0.0016 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0194
Brugia malayi heat shock protein 90 0.0036 0.0138 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0119 0.0194
Trypanosoma cruzi polo-like protein kinase, putative 0.0078 0.0375 1
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114 0.0579 0.0942
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0119 0.0194
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0128 0.3425
Plasmodium falciparum lipid/sterol:H+ symporter 0.0013 0.0006 0.0221
Schistosoma mansoni hypothetical protein 0.0089 0.0438 0.0712
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0033 0.1141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0119 0.0194
Trypanosoma brucei heat shock protein, putative 0.0036 0.0138 0.3692
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0119 0.0194
Trypanosoma brucei polo-like protein kinase 0.0078 0.0375 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Echinococcus granulosus geminin 0.0165 0.0866 0.141
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0128 0.4425
Loa Loa (eye worm) patched family protein 0.0013 0.0006 0.001
Loa Loa (eye worm) subtilase 0.0055 0.0245 0.0398
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Brugia malayi hypothetical protein 0.0017 0.0031 0.005
Brugia malayi hypothetical protein 0.0026 0.0082 0.0133
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.0096 0.0072
Schistosoma mansoni kinase 0.004 0.0158 0.0257
Loa Loa (eye worm) patched family protein 0.0013 0.0006 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0073
Brugia malayi MH2 domain containing protein 0.0018 0.0033 0.0054
Entamoeba histolytica hypothetical protein 0.0051 0.0223 0.1928
Schistosoma mansoni heat shock protein 0.0036 0.0138 0.0225
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.002 0.0033
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0267 0.0435
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0262 0.1415 0.2301
Loa Loa (eye worm) hypothetical protein 0.0055 0.0245 0.0398
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.0457 0.0743
Schistosoma mansoni hypothetical protein 0.005 0.0213 0.0347
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Schistosoma mansoni hypothetical protein 0.0079 0.0379 0.0617
Schistosoma mansoni cpg binding protein 0.0032 0.0114 0.0186
Schistosoma mansoni lamin 0.0059 0.0267 0.0435
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0119 0.0194
Onchocerca volvulus 0.0027 0.0083 0.0263
Echinococcus granulosus integrin alpha ps 0.0068 0.0315 0.0513
Brugia malayi RNA, U transporter 1 0.018 0.095 0.1546
Toxoplasma gondii subtilisin SUB9 0.0055 0.0245 0.8435
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.0009 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0119 0.0194
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0319 0.0519
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0194
Schistosoma mansoni gabp alpha 0.0081 0.0388 0.0632
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0027 0.0082 0.2832
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.002 0.0033
Brugia malayi hypothetical protein 0.0013 0.0006 0.001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0676 0.3754 0.6108
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0194
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0138 0.3692
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0055 0.0245 0.6366
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.021 0.021
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0375 0.1144
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0353 0.1928 0.5883
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0245 0.0747
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0821 0.1336
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0119 0.0387
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0213 0.0347
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0119 0.0194
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.013 0.0665 0.0665
Onchocerca volvulus 0.014 0.0726 0.247
Echinococcus granulosus enteropeptidase 0.0049 0.0212 0.0345
Echinococcus multilocularis fibrillin 1 0.0014 0.0013 0.0013
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.002 0.0048
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0083 0.0055
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.2527 0.2527
Schistosoma mansoni nuclear receptor 0.0016 0.002 0.0033
Schistosoma mansoni cpg binding protein 0.0034 0.0125 0.0203
Schistosoma mansoni site-1 peptidase (S08 family) 0.0055 0.0245 0.0398
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0078 0.0375 0.061
Giardia lamblia Furin precursor putative serine protease 0.0298 0.1616 1
Toxoplasma gondii patched family protein 0.0013 0.0006 0.0221
Mycobacterium leprae Possible secreted protease 0.0055 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0119 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0119 0.0194
Giardia lamblia Grp94/Hsp90 0.0029 0.0096 0.0093
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0033 0.1141
Trypanosoma brucei subtilisin peptidase 0.0055 0.0245 0.6529
Entamoeba histolytica serine/threonine protein kinase, putative 0.0078 0.0375 0.3248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0119 0.0194
Brugia malayi tailless protein 0.0016 0.002 0.0033
Echinococcus multilocularis Niemann Pick C1 protein 0.0309 0.1679 0.1679
Echinococcus granulosus membrane bound transcription factor site 1 0.0055 0.0245 0.0398
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Toxoplasma gondii patched family protein 0.0013 0.0006 0.0221
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0119 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Brugia malayi Ets-domain containing protein 0.0081 0.0388 0.0632
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.021 0.0342
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0081 0.0388 0.0632
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Loa Loa (eye worm) pax transcription factor protein 2 0.0528 0.292 0.4751
Schistosoma mansoni smad1 5 8 and 0.0018 0.0033 0.0054
Trypanosoma cruzi PAB1-binding protein , putative 0.0041 0.0164 0.41
Schistosoma mansoni hypothetical protein 0.0323 0.176 0.2863
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0013 0.0003 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.021 0.0342
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0353 0.1928 0.5883
Brugia malayi Fli-1 protein 0.0245 0.1316 0.2142
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0045 0.1547
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0027 0.0082 0.0134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.021 0.021
Echinococcus multilocularis musashi 0.0059 0.0267 0.0267
Brugia malayi Kringle domain containing protein 0.0018 0.0033 0.0054
Echinococcus multilocularis smad 0.0018 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0194
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0194
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0033 0.0054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0591 0.3278 1
Brugia malayi Subtilase family protein 0.0055 0.0245 0.0398
Echinococcus multilocularis protein patched 0.0093 0.0457 0.0457
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0119 0.0194
Schistosoma mansoni hypothetical protein 0.0459 0.2527 0.4111
Plasmodium falciparum subtilisin-like protease 1 0.0055 0.0245 0.8435
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0119 0.0194
Toxoplasma gondii heat shock protein 75, putative 0.0015 0.0017 0.0578
Loa Loa (eye worm) hypothetical protein 0.0114 0.0575 0.0935
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.0041 0.0164 0.5638
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0119 0.0603 0.0982
Echinococcus multilocularis enteropeptidase 0.0049 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0203 0.108 0.1757
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0059 0.0179
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0009 0.0014
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0029 0.0096 0.0831
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0055 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0267 0.0435
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Schistosoma mansoni hypothetical protein 0.0032 0.0116 0.0189
Plasmodium vivax patched family protein, putative 0.0013 0.0006 0.0221
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0103 0.0514 0.0836
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0591 0.3278 0.3278
Plasmodium vivax heat shock protein 90, putative 0.0015 0.0017 0.0578
Echinococcus granulosus heat shock protein 90 0.0036 0.0138 0.0225
Echinococcus granulosus lamin dm0 0.0059 0.0267 0.0435
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0119 0.0387
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.0457 0.0457
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0033 0.0054
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0083 0.0048
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0017 0.0578
Schistosoma mansoni smad 0.0018 0.0033 0.0054
Toxoplasma gondii heat shock protein HSP90 0.0036 0.0138 0.477
Echinococcus multilocularis rho associated protein kinase 0.0141 0.0729 0.0729
Loa Loa (eye worm) patched family protein 0.0013 0.0006 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0119 0.0194
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0213 0.0347
Loa Loa (eye worm) hypothetical protein 0.0093 0.0457 0.0743
Brugia malayi Pax transcription factor protein 2 0.0528 0.292 0.4751
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0027 0.0082 0.0134
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0078 0.0375 0.0375
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.025 0.1347 0.2191
Echinococcus granulosus neuropeptide receptor A26 0.0525 0.2903 0.4723
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Toxoplasma gondii patched family protein 0.0013 0.0006 0.0221
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0031 0.005
Toxoplasma gondii subtilisin SUB10 0.0055 0.0245 0.8435
Echinococcus granulosus furin 0.1099 0.6146 1
Brugia malayi Patched related family protein 12 0.0013 0.0006 0.001
Brugia malayi nuclear hormone receptor 0.0016 0.002 0.0033
Onchocerca volvulus 0.0016 0.002 0.0048
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0437 0.2405 0.3914
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0083 0.2214
Brugia malayi nuclear hormone receptor 0.0033 0.0119 0.0194
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0128 0.0209
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.002 0.0033
Schistosoma mansoni site-1 peptidase (S08 family) 0.0055 0.0245 0.0398
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0128 0.4425
Onchocerca volvulus Serine\/threonine kinase homolog 0.0078 0.0375 0.1265
Plasmodium vivax heat shock protein, putative 0.0015 0.0017 0.0578
Brugia malayi hypothetical protein 0.0079 0.0379 0.0617
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0055 0.0245 0.0258
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0033 0.0054
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0096 0.0294
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0033 0.0457
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0119 0.0194
Brugia malayi Latrophilin receptor protein 2 0.005 0.0213 0.0347
Brugia malayi CXXC zinc finger family protein 0.0032 0.0114 0.0186
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.002 0.0033
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0033 0.0054
Brugia malayi MH2 domain containing protein 0.0018 0.0033 0.0054
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0119 0.0194
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.002 0.002
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.0009 0.0014
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0196 0.522
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.002 0.0033
Trichomonas vaginalis ap endonuclease, putative 0.0027 0.0082 0.0251
Schistosoma mansoni heat shock protein 0.0036 0.0138 0.0225
Brugia malayi nuclear receptor RXR 0.0016 0.002 0.0033
Echinococcus multilocularis muscleblind protein 1 0.016 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0216 0.1155 0.1879
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0135
Brugia malayi nuclear receptor RXR 0.0017 0.0031 0.005
Schistosoma mansoni coup transcription factor 0.0033 0.0119 0.0194
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0018 0.0036 0.0036
Echinococcus multilocularis neuropeptide s receptor 0.0525 0.2903 0.2903
Schistosoma mansoni egf-like domain protein 0.0014 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0107 0.054 0.0878
Brugia malayi hypothetical protein 0.0013 0.0006 0.001
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0055 0.0245 0.0398
Echinococcus granulosus neuropeptide s receptor 0.0525 0.2903 0.4723
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0027 0.0082 0.0047
Brugia malayi serine/threonine-protein kinase plk-2 0.0078 0.0375 0.061
Echinococcus granulosus Niemann Pick C1 protein 0.0216 0.1155 0.1879
Echinococcus granulosus Tolloid protein 1 0.0014 0.0009 0.0014
Schistosoma mansoni ets-related 0.0245 0.1316 0.2142
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0128 0.3117
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0245 0.0747
Schistosoma mansoni Smad4 0.0018 0.0033 0.0054
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0196 0.0319
Trypanosoma brucei PAB1-binding protein , putative 0.0041 0.0164 0.4364
Schistosoma mansoni cpg binding protein 0.0034 0.0125 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.005
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0196 0.0319
Loa Loa (eye worm) hypothetical protein 0.0157 0.0821 0.1336
Schistosoma mansoni integrin alpha-ps 0.0068 0.0315 0.0513
Brugia malayi hypothetical protein 0.0269 0.1453 0.2365
Mycobacterium ulcerans heat shock protein 90 0.0029 0.0096 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Toxoplasma gondii subtilisin SUB12 0.0055 0.0245 0.8435
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0031 0.005
Toxoplasma gondii subtilisin SUB4 0.0055 0.0245 0.8435
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Echinococcus multilocularis X box binding protein 1 0.0323 0.176 0.176
Echinococcus multilocularis heat shock protein 0.0036 0.0138 0.0138
Echinococcus multilocularis integrin alpha ps 0.0068 0.0315 0.0315
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0094 0.0153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0132 0.0214
Plasmodium falciparum heat shock protein 90 0.0036 0.0138 0.477
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.013 0.0665 0.1082
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0014
Brugia malayi nuclear receptor NHR-88 0.0033 0.0119 0.0194
Brugia malayi Muscleblind-like protein 0.016 0.0839 0.1366
Brugia malayi conserved hypotetical protein 0.0016 0.002 0.0033
Brugia malayi Niemann-Pick C1 protein precursor 0.0216 0.1155 0.1879
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Plasmodium vivax subtilisin-like protease 2, putative 0.0055 0.0245 0.8435
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.002 0.0048
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0298 0.1616 0.4929
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0194
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Echinococcus granulosus lamin 0.0059 0.0267 0.0435
Echinococcus multilocularis neuropeptide receptor A26 0.0525 0.2903 0.2903
Echinococcus multilocularis importin subunit beta 1 0.0063 0.029 0.029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0119 0.0194
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.005
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0055 0.0245 0.0398
Brugia malayi hypothetical protein 0.0013 0.0006 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0119 0.0194
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0014
Echinococcus multilocularis geminin 0.0165 0.0866 0.0866
Echinococcus granulosus heat shock protein 90 0.0029 0.0096 0.0157
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0083 0.2214
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0054
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0119 0.0119
Echinococcus granulosus importin subunit beta 1 0.0063 0.029 0.0472
Leishmania major subtilisin-like serine peptidase 0.0055 0.0245 0.6529
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.002 0.002
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.002 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.002 0.002
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0138 0.1199
Brugia malayi proprotein convertase 2 0.086 0.4797 0.7804
Plasmodium falciparum ataxin-2 like protein, putative 0.0041 0.0164 0.5638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0119 0.0194
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1099 0.6146 1
Brugia malayi hypothetical protein 0.0016 0.002 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0267 0.0435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0119 0.0194
Schistosoma mansoni hypothetical protein 0.0089 0.0438 0.0712
Brugia malayi Smad1 0.0018 0.0033 0.0054
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.029 1
Plasmodium vivax endoplasmin, putative 0.0036 0.0138 0.477
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.021 0.0342
Trypanosoma cruzi PAB1-binding protein , putative 0.0041 0.0164 0.41
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0112 0.0182
Schistosoma mansoni hypothetical protein 0.005 0.0213 0.0347
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0073
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Echinococcus multilocularis expressed conserved protein 0.0203 0.1081 0.1081
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0083 0.2214
Giardia lamblia High cysteine membrane protein Group 2 0.0286 0.1551 0.9576
Trypanosoma brucei heat shock protein, putative 0.0036 0.0138 0.3692
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0055 0.0245 0.0398
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Brugia malayi Ets-domain containing protein 0.0081 0.0388 0.0632
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0223 0.0679
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0223 0.0679
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0591 0.3278 0.5333
Onchocerca volvulus 0.0016 0.002 0.0048
Schistosoma mansoni furin-1 (S08 family) 0.0562 0.3113 0.5065
Toxoplasma gondii subtilisin SUB8 0.0055 0.0245 0.8435
Echinococcus multilocularis muscleblind protein 0.016 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0153
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Echinococcus granulosus rho-associated protein kinase 1 0.0141 0.0729 0.1187
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0049 0.0212 0.0345
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Echinococcus multilocularis Smad4 0.0018 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Loa Loa (eye worm) endoplasmin 0.0036 0.0138 0.0225
Entamoeba histolytica hypothetical protein 0.0079 0.0379 0.3282
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0073
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0055 0.0245 1
Echinococcus multilocularis epidermal growth factor receptor 0.0182 0.0963 0.0963
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0096 0.2225
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Schistosoma mansoni hypothetical protein 0.0165 0.0866 0.141
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0112 0.0182
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.005
Brugia malayi MH1 domain containing protein 0.0018 0.0033 0.0054
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.025 0.1347 0.4109
Loa Loa (eye worm) TK/EGFR protein kinase 0.0182 0.0963 0.1566
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0114 0.0186
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Loa Loa (eye worm) patched family protein 0.0013 0.0006 0.001
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0196 0.0741
Onchocerca volvulus 0.0059 0.0267 0.0895
Toxoplasma gondii subtilisin SUB5 0.0055 0.0245 0.8435
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0119 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0375 0.1144
Loa Loa (eye worm) hypothetical protein 0.0041 0.0164 0.0266
Schistosoma mansoni endoplasmin 0.0036 0.0138 0.0225
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0033 0.0054
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.0138 0.3396
Echinococcus multilocularis heat shock protein 90 0.0029 0.0096 0.0096
Echinococcus multilocularis Niemann Pick C1 protein 0.0216 0.1155 0.1155
Schistosoma mansoni endoplasmin 0.0036 0.0138 0.0225
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0009 0.0301
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0196 0.6744
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0143
Brugia malayi Fibulin-1 precursor 0.0014 0.0009 0.0014
Brugia malayi celfurPC protein 0.0848 0.4732 0.7698
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0119 0.0194
Brugia malayi isocitrate dehydrogenase 0.0035 0.0128 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0375 0.1144
Toxoplasma gondii subtilisin SUB1 0.0055 0.0245 0.8435
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0018 0.0036 0.0059
Leishmania major hypothetical protein, conserved 0.0041 0.0164 0.4364
Brugia malayi hypothetical protein 0.0519 0.2868 0.4666
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0119 0.0194
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0027 0.0082 0.2192
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0055 0.0245 0.0251
Loa Loa (eye worm) hypothetical protein 0.0058 0.0261 0.0425
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0201 0.0613
Echinococcus multilocularis neuroendocrine convertase 2 0.086 0.4797 0.4797
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0591 0.3278 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0353 0.1928 0.5883
Leishmania major importin beta-1 subunit, putative 0.0051 0.0223 0.5935
Brugia malayi MH2 domain containing protein 0.0262 0.1415 0.2301
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0213 0.0347
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0119 0.0119
Plasmodium falciparum importin beta, putative 0.0063 0.029 1
Brugia malayi Patched protein homolog 1 0.0013 0.0006 0.001
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0119 0.0387
Echinococcus multilocularis glycoprotein Antigen 5 0.0049 0.0212 0.0212
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0128 0.0209
Brugia malayi follicle stimulating hormone receptor 0.0256 0.1381 0.2247
Echinococcus granulosus snurportin 1 0.0676 0.3754 0.6108
Echinococcus granulosus endoplasmin 0.0029 0.0096 0.0157
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Echinococcus granulosus Mastin 0.0049 0.0212 0.0345
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.002 0.0033
Toxoplasma gondii subtilisin SUB7 0.0055 0.0245 0.8435
Trypanosoma brucei heat shock protein, putative 0.0036 0.0138 0.3692
Brugia malayi CHE-14 protein 0.0093 0.0457 0.0743
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0135
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0083 0.0048
Schistosoma mansoni integrin alpha 0.0151 0.0787 0.128
Schistosoma mansoni hypothetical protein 0.0676 0.3754 0.6108
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.0531 0.0864
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Treponema pallidum heat shock protein 90 0.0029 0.0096 1
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0138 0.3396
Loa Loa (eye worm) hypothetical protein 0.0269 0.1453 0.2365
Onchocerca volvulus 0.0032 0.0114 0.0371
Brugia malayi Furin-like cysteine rich region family protein 0.0182 0.0963 0.1566
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Onchocerca volvulus 0.0106 0.0531 0.1801
Loa Loa (eye worm) hypothetical protein 0.016 0.0839 0.1366
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0119 0.0194
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0045 0.0008
Echinococcus granulosus expressed conserved protein 0.0203 0.1081 0.1758
Trypanosoma brucei heat shock protein, putative 0.0036 0.0138 0.3692
Schistosoma mansoni ap endonuclease 0.0027 0.0082 0.0134
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0138 0.3692
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0128 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.021 0.0342
Brugia malayi exodeoxyribonuclease III family protein 0.0027 0.0082 0.0134
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0128 0.3425
Onchocerca volvulus 0.0141 0.0729 0.2481
Loa Loa (eye worm) hypothetical protein 0.0114 0.0579 0.0942
Loa Loa (eye worm) nuclear hormone receptor 0.0112 0.0566 0.0921
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0017 0.0051
Schistosoma mansoni hypothetical protein 0.0165 0.0866 0.141
Trypanosoma brucei heat shock protein, putative 0.0036 0.0138 0.3692
Echinococcus multilocularis Mastin 0.0049 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0353 0.1928 0.5883
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0027 0.0082 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0119 0.0194
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0083 0.0048
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0119 0.0194
Trypanosoma brucei heat shock protein, putative 0.0036 0.0138 0.3692
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.002 0.0033
Echinococcus granulosus integrin alpha ps 0.0032 0.0116 0.0189
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0128 0.0112
Toxoplasma gondii patched family protein 0.0013 0.0006 0.0221
Toxoplasma gondii subtilisin SUB6 0.0055 0.0245 0.8435
Loa Loa (eye worm) hypothetical protein 0.0176 0.093 0.1513
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0015 0.0017 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0375 0.061
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0138 0.3396
Echinococcus multilocularis cpg binding protein 0.0034 0.0125 0.0125
Echinococcus granulosus Protein patched homolog 1 0.0093 0.0457 0.0743
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0267 0.0435
Schistosoma mansoni patched 1 0.0093 0.0457 0.0743
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0119 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Loa Loa (eye worm) integrin alpha pat-2 0.0233 0.125 0.2033
Leishmania major heat shock protein, putative 0.0015 0.0017 0.0447
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0083 0.0135
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0096 0.2572
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0027 0.0082 0.1826
Onchocerca volvulus Arrow homolog 0.0014 0.0009 0.0008
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0096 0.0157
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.029 0.774
Brugia malayi Integrin alpha pat-2 precursor 0.0151 0.0787 0.128
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0055 0.0245 0.0398
Schistosoma mansoni nuclear hormone receptor 0.0016 0.002 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0119 0.0194
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0143
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Onchocerca volvulus Huntingtin homolog 0.0269 0.1453 0.4965
Echinococcus multilocularis integrin alpha ps 0.0068 0.0315 0.0315
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0152 0.0465
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0055 0.0245 0.0258
Plasmodium falciparum subtilisin-like protease 3 0.0055 0.0245 0.8435
Schistosoma mansoni smad1 5 8 and 0.0018 0.0033 0.0054
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0119 0.0194
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0027 0.0082 0.2832
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0055 0.0245 0.6529
Echinococcus granulosus intermediate filament protein 0.0059 0.0267 0.0435
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0054 0.1039
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0119 0.0194
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0009 0.0301
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0033 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0083 0.0055
Trypanosoma brucei heat shock protein, putative 0.0036 0.0138 0.3692
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0119 0.0119
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0055 0.0245 0.0258
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0277 0.9557
Echinococcus granulosus integrin alpha 3 0.0116 0.0587 0.0956
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0119 0.0119
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Brugia malayi Importin beta-1 subunit 0.0063 0.029 0.0472
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0015 0.0017 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0457 0.1394
Loa Loa (eye worm) hypothetical protein 0.0114 0.0577 0.0938
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0353 0.1928 0.5883
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0027 0.0082 0.1826
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Giardia lamblia Kinase, PLK 0.0078 0.0375 0.191
Loa Loa (eye worm) heat shock protein 75 0.0015 0.0017 0.0027
Echinococcus granulosus Niemann Pick C1 protein 0.0309 0.1679 0.2732
Echinococcus granulosus muscleblind protein 0.016 0.0839 0.1366
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0223 0.5744
Loa Loa (eye worm) endoprotease bli-4 0.1099 0.6146 1
Echinococcus multilocularis lamin 0.0059 0.0267 0.0267
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0096 0.0294
Echinococcus granulosus X box binding protein 1 0.0323 0.176 0.2863
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.054 0.0878
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0045 0.1547
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0096 0.0294
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Echinococcus granulosus laminin 0.0014 0.0009 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0379 0.0617
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0119 0.0194
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0128 0.0128
Onchocerca volvulus 0.0055 0.0245 0.0818
Onchocerca volvulus 0.0033 0.0119 0.0387
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0055 0.0245 0.0251
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.002 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0014
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0029 0.0096 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0041 0.0164 0.5638
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0045 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0033 0.0054
Brugia malayi hypothetical protein 0.0017 0.0031 0.005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0196 0.4996
Onchocerca volvulus Huntingtin homolog 0.0269 0.1453 0.4965
Brugia malayi Nuclear hormone receptor E75 0.0016 0.002 0.0033
Brugia malayi Protein kinase domain containing protein 0.0437 0.2405 0.3914
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0083 0.0719
Brugia malayi Endoplasmin precursor 0.0036 0.0138 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0729 0.1187
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0119 0.0194
Schistosoma mansoni ran 0.0047 0.0196 0.0319
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0033 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0083 0.0135
Echinococcus multilocularis membrane bound transcription factor site 1 0.0055 0.0245 0.0245
Echinococcus granulosus survival motor neuron protein 1 0.0519 0.2868 0.4666
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0128 0.4425
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Entamoeba histolytica hypothetical protein 0.0079 0.0379 0.3282
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.002 0.0033
Brugia malayi Myosin head containing protein 0.0013 0.0006 0.001
Echinococcus granulosus GA binding protein alpha chain 0.0081 0.0388 0.0632
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.0138 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0119 0.0194
Brugia malayi hypothetical protein 0.0041 0.0164 0.0266
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0152 0.0465
Schistosoma mansoni importin beta-1 0.0063 0.029 0.0472
Schistosoma mansoni ap endonuclease 0.0027 0.0082 0.0134
Echinococcus multilocularis endoplasmin 0.0029 0.0096 0.0096
Toxoplasma gondii subtilisin SUB11 0.0055 0.0245 0.8435
Trypanosoma brucei heat shock protein, putative 0.0036 0.0138 0.3692
Echinococcus multilocularis integrin alpha 3 0.0116 0.0587 0.0587
Brugia malayi hypothetical protein 0.0013 0.0006 0.001
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0055 0.0245 0.0258
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0138 0.0422
Plasmodium vivax importin-beta 2, putative 0.0063 0.029 1
Echinococcus multilocularis GA binding protein alpha chain 0.0081 0.0388 0.0388
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0083 0.0048
Schistosoma mansoni heat shock protein 0.0015 0.0017 0.0027
Echinococcus granulosus neuroendocrine convertase 2 0.086 0.4797 0.7804
Toxoplasma gondii hypothetical protein 0.0013 0.0006 0.0221
Loa Loa (eye worm) hypothetical protein 0.1099 0.6146 1
Plasmodium falciparum subtilisin-like protease 2 0.0055 0.0245 0.8435
Brugia malayi N-terminal motif family protein 0.0203 0.108 0.1757
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0078 0.0375 0.061
Toxoplasma gondii Hsp90 domain-containing protein 0.0015 0.0017 0.0578
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0196 0.6744
Loa Loa (eye worm) fli-1 protein 0.0245 0.1316 0.2142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.021 0.0342
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0119 0.0194
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0059
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0128 0.0128
Brugia malayi ecdysone receptor 0.0016 0.002 0.0033
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0119 0.0119
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0103 0.0514 0.1567
Brugia malayi steroid hormone receptor 0.0033 0.0119 0.0194
Toxoplasma gondii exonuclease III APE 0.0027 0.0082 0.2832
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0138 0.1199
Schistosoma mansoni nuclear hormone receptor 0.0016 0.002 0.0033
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0059 0.0179
Loa Loa (eye worm) DR-78 0.0016 0.002 0.0033
Brugia malayi protein C24B5.3 0.0013 0.0006 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.021 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0194
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.002 0.0033
Mycobacterium ulcerans hypothetical protein 0.0027 0.0083 0.0048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0189
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Plasmodium vivax subtilisin-like protease 1 0.0055 0.0245 0.8435
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0375 0.1144
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0027 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0083 0.0719
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0216 0.1155 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0015 0.0017 0.0017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0031 0.005
Brugia malayi hypothetical protein 0.0016 0.002 0.0033
Echinococcus multilocularis lamin dm0 0.0059 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0203 0.108 0.3684
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0014 0.0009 0.0014
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.0138 0.477
Loa Loa (eye worm) heat shock protein 90 0.0036 0.0138 0.0225
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0083 0.0135
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0128 0.3425
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0033 0.0054
Schistosoma mansoni lamin 0.0059 0.0267 0.0435
Schistosoma mansoni zinc finger protein 0.0016 0.002 0.0033
Toxoplasma gondii LsmAD domain-containing protein 0.0041 0.0164 0.5638
Brugia malayi MH1 domain containing protein 0.0018 0.0033 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0379 0.0379
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0375 0.1144
Trypanosoma cruzi subtilisin peptidase 0.0055 0.0245 0.6366
Onchocerca volvulus 0.0018 0.0033 0.0092
Brugia malayi Nuclear hormone receptor E75 0.0016 0.002 0.0033
Schistosoma mansoni survival motor neuron protein 0.0106 0.0531 0.0864
Schistosoma mansoni integrin alpha-ps 0.0035 0.0132 0.0214
Leishmania major heat shock protein 83-1 0.0036 0.0138 0.3692
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0213 0.0347
Echinococcus multilocularis laminin 0.0014 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0245 0.0747
Trypanosoma cruzi polo-like protein kinase, putative 0.0078 0.0375 1
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.0457 0.0743
Echinococcus granulosus heat shock protein 0.0036 0.0138 0.0225
Plasmodium falciparum endoplasmin, putative 0.0022 0.0059 0.2024
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0524
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0353 0.1928 0.5883
Loa Loa (eye worm) Smad1 0.0018 0.0033 0.0054
Entamoeba histolytica hypothetical protein 0.0079 0.0379 0.3282
Brugia malayi Patched family protein 0.0013 0.0006 0.001
Entamoeba histolytica hypothetical protein 0.0079 0.0379 0.3282
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0119 0.0119
Schistosoma mansoni intermediate filament proteins 0.0059 0.0267 0.0435
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0083 0.0048
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.1381 0.2247
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0031 0.0031
Trichomonas vaginalis ap endonuclease, putative 0.0027 0.0082 0.0251
Onchocerca volvulus 0.0528 0.292 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.029 0.0472
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0138 0.3396
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.1431 0.8025 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0119 0.0194
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0379 0.0617
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0055 0.0245 0.6366
Echinococcus multilocularis 0.0848 0.4732 0.4732
Plasmodium vivax heat shock protein 86, putative 0.0036 0.0138 0.477
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Brugia malayi Steroid receptor seven-up type 2 0.013 0.0665 0.1082
Brugia malayi Patched related family protein 4 0.0013 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0194
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0083 0.0719
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0119 0.0194
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0055 0.0245 0.0251
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0196 0.0196
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0033 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Entamoeba histolytica Ran family GTPase 0.0047 0.0196 0.1696
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0119 0.0119
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.002 0.002
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0128 0.4425
Schistosoma mansoni hypothetical protein 0.0106 0.0531 0.0864
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0017 0.0578
Brugia malayi Patched related family protein 10 0.0013 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0083 0.0404 0.0657
Schistosoma mansoni hypothetical protein 0.005 0.0213 0.0347
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0128 0.0209
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Trichomonas vaginalis ran, putative 0.0047 0.0196 0.0597
Onchocerca volvulus 0.0059 0.0267 0.0895
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0119 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0245 0.0747
Echinococcus multilocularis Tolloid protein 1 0.0014 0.0009 0.0009
Echinococcus multilocularis integrin alpha ps 0.0032 0.0116 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0375 0.1144
Echinococcus granulosus GPCR family 2 0.005 0.0213 0.0347
Echinococcus multilocularis snurportin 1 0.0676 0.3754 0.3754
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0073
Leishmania major GTP-binding protein, putative 0.0047 0.0196 0.522
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0055 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.005
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1347 0.4109
Brugia malayi Hsp90 protein 0.0015 0.0017 0.0027

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) NT 0 mg kg-1 Inhibition of amphetamine induced stereotypy in rats; pretreated 24 h before amphetamine. ChEMBL. 6104732
ED50 (functional) = 3.2 mg kg-1 Tested for neuroleptic activity by measuring antagonism of d-amphetamine sulfate at intraperitoneal dosage of 5mg/kg, after 1 hour in rat; Range is 3.2-10 ChEMBL. 6104732
ED50 (functional) = 3.2 mg kg-1 Tested for neuroleptic activity by measuring antagonism of d-amphetamine sulfate at intraperitoneal dosage of 5mg/kg, after 5 hours in rat; Range is 3.2-10 ChEMBL. 6104732

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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