Detailed information for compound 281722

Basic information

Technical information
  • TDR Targets ID: 281722
  • Name: 4-[6-(2-chloro-4-fluorophenoxy)hexyl]-3,5-die thyl-1,2-oxazole
  • MW: 353.859 | Formula: C19H25ClFNO2
  • H donors: 0 H acceptors: 1 LogP: 6.49 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1onc(c1CCCCCCOc1ccc(cc1Cl)F)CC
  • InChi: 1S/C19H25ClFNO2/c1-3-17-15(18(4-2)24-22-17)9-7-5-6-8-12-23-19-11-10-14(21)13-16(19)20/h10-11,13H,3-9,12H2,1-2H3
  • InChiKey: IHNLEOQDWIJFLG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[6-(2-chloro-4-fluoro-phenoxy)hexyl]-3,5-diethyl-isoxazole
  • 4-[6-(2-chloro-4-fluorophenoxy)hexyl]-3,5-diethylisoxazole
  • 4-[6-(2-chloro-4-fluoro-phenoxy)hexyl]-3,5-diethyl-1,2-oxazole
  • AIDS-190766
  • AIDS190766
  • Isoxazole, 4-[6-(2-chloro-4-fluorophenoxy)hexyl]-3,5-diethyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sex peptide receptor 0.0389 0.1808 0.1808
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0011 0.0011
Echinococcus granulosus fmrfamide receptor 0.0389 0.1808 0.1808
Echinococcus granulosus dro:myosuppressin receptor 0.0389 0.1808 0.1808
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0389 0.1808 0.1808
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0452 0.1399
Schistosoma mansoni hypothetical protein 0.0389 0.1808 0.1799
Mycobacterium tuberculosis Conserved protein 0.0037 0.0113 0.0974
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0389 0.1808 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.1213 0.2677
Toxoplasma gondii GAF domain-containing protein 0.0057 0.0213 0.0655
Leishmania major cytochrome p450-like protein 0.0028 0.0072 0.0195
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0213 0.0213
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0511 0.0501
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0041 0.006
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0107 0.0452 0.2967
Schistosoma mansoni cytochrome P450 0.0028 0.0072 0.0062
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0389 0.1808 0.1802
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 1
Schistosoma mansoni importin beta-1 0.0029 0.0077 0.0067
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0011 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0161 0.0161
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0011 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0077 0.024
Echinococcus multilocularis lamin dm0 0.0027 0.0067 0.0067
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0156 0.0461
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0113 0.0337
Echinococcus multilocularis dna polymerase kappa 0.0019 0.003 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0161 0.0151
Echinococcus multilocularis dna polymerase eta 0.0019 0.003 0.003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0113 0.0113
Trypanosoma brucei cytochrome P450, putative 0.0046 0.0156 0.0489
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0161 0.0161
Onchocerca volvulus 0.0389 0.1808 0.3935
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1464 0.3238
Brugia malayi jmjC domain containing protein 0.0015 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0113 0.0974
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0107 0.0452 0.0452
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0119 0.0511 0.0501
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.1464 1
Echinococcus multilocularis neuropeptide receptor 0.0389 0.1808 0.1808
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0028 0.0394
Echinococcus granulosus adenylate cyclase type IX 0.0109 0.0462 0.0462
Echinococcus granulosus lamin 0.0027 0.0067 0.0067
Toxoplasma gondii hypothetical protein 0.0158 0.0697 0.2188
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0025 0.0332
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0208 0.0936 0.206
Onchocerca volvulus 0.0389 0.1808 0.3935
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0222 0.2009
Plasmodium vivax JmjC domain containing protein 0.0015 0.0011 0.0011
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0671 0.3165 1
Echinococcus granulosus neuropeptide Y receptor 0.0389 0.1808 0.1808
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 0.1425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0161 0.0151
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0671 0.3165 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.003 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0113 0.0222
Echinococcus granulosus neuropeptide receptor A26 0.0389 0.1808 0.1808
Echinococcus granulosus tm gpcr rhodopsin 0.0389 0.1808 0.1808
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0208 0.0936 0.2934
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0605 0.1883
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0028 0.0072 0.0713
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1464 0.3238
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092
Schistosoma mansoni hypothetical protein 0.0341 0.158 0.1571
Onchocerca volvulus 0.0389 0.1808 0.3935
Loa Loa (eye worm) cytochrome P450 0.0028 0.0072 0.0072
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0605 0.1883
Brugia malayi Tachykinin-like peptides receptor 99D 0.0389 0.1808 0.1802
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.2091 1 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0028 0.0072 0.0713
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0222 0.0671
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0452 0.1399
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0452 0.1399
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0069 0.0184
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0028 0.0072 0.0583
Brugia malayi jmjC domain containing protein 0.0015 0.0011 0.0004
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0015
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0164 0.0728 0.1596
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus multilocularis neuropeptide FF receptor 2 0.0389 0.1808 0.1808
Brugia malayi G-protein coupled receptor 0.0389 0.1808 0.1802
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0671 0.3165 1
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0452 0.1399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0067 0.0067
Brugia malayi Cytochrome P450 family protein 0.0046 0.0156 0.0149
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.1348 0.4238
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0107 0.0452 0.1425
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0028 0.0072 0.0583
Echinococcus granulosus rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0389 0.1808 0.1802
Brugia malayi Pre-SET motif family protein 0.0832 0.3938 0.3934
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0671 0.3165 1
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Onchocerca volvulus 0.0037 0.0113 0.0104
Echinococcus multilocularis G-protein coupled receptor, putative 0.0389 0.1808 0.1808
Echinococcus granulosus neuropeptide receptor 0.0389 0.1808 0.1808
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0067 0.0067
Mycobacterium ulcerans lipase LipD 0.0037 0.0113 0.1339
Echinococcus granulosus snurportin 1 0.0311 0.1433 0.1433
Echinococcus multilocularis dro:myosuppressin receptor 0.0389 0.1808 0.1808
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0389 0.1808 0.1799
Onchocerca volvulus 0.0389 0.1808 0.3935
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0011 0.0014
Mycobacterium leprae conserved hypothetical protein 0.0057 0.0213 0.2309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1464 0.3238
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0389 0.1808 0.1808
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0389 0.1808 0.1799
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0389 0.1808 0.1808
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0115 0.049 0.049
Schistosoma mansoni biogenic amine receptor 0.0389 0.1808 0.1799
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0265 0.1213 0.381
Echinococcus multilocularis serotonin receptor 0.0389 0.1808 0.1808
Onchocerca volvulus 0.0389 0.1808 0.3935
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.0683 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0085 0.0344 0.0344
Echinococcus granulosus orexin receptor type 2 0.0389 0.1808 0.1808
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0156 0.0156
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0389 0.1808 0.1808
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0389 0.1808 0.1799
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Schistosoma mansoni hypothetical protein 0.0389 0.1808 0.1799
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0265 0.1213 0.2677
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Leishmania major importin beta-1 subunit, putative 0.0024 0.0051 0.0127
Loa Loa (eye worm) neuropeptide F receptor 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.002
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 0.1425
Schistosoma mansoni amine GPCR 0.0389 0.1808 0.1799
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0069 0.0195
Echinococcus multilocularis neuropeptide Y receptor 0.0389 0.1808 0.1808
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0113 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Brugia malayi RE15519p 0.0389 0.1808 0.1802
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0213 0.0213
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0389 0.1808 0.1808
Onchocerca volvulus 0.0946 0.4491 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0025 0.0047
Loa Loa (eye worm) neuropeptide F receptor 0.0389 0.1808 0.1808
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0011 0.0011
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0389 0.1808 0.1802
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.003 0.0092
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0113 0.0113
Brugia malayi Cytochrome P450 family protein 0.0028 0.0072 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0028 0.0072 0.0583
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0011 0.0014
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0179 0.0533
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0107 0.0452 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.003 0.0092
Loa Loa (eye worm) PDE1B protein 0.2091 1 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0113 0.0974
Brugia malayi putative neuropeptide receptor NPR1 0.0389 0.1808 0.1802
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0222 0.0212
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0019 0.0008
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0107 0.0452 0.0452
Brugia malayi intermediate filament protein 0.0027 0.0067 0.0061
Echinococcus multilocularis sex peptide receptor 0.0389 0.1808 0.1808
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.068 0.6354
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0113 0.0326
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0072 0.0195
Loa Loa (eye worm) TYRA-2 protein 0.0389 0.1808 0.1808
Echinococcus granulosus biogenic amine 5HT receptor 0.0389 0.1808 0.1808
Echinococcus granulosus geminin 0.0341 0.158 0.158
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0011 0.0014
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0113 0.0113
Schistosoma mansoni myosin xvIII 0.0389 0.1808 0.1799
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0222 0.2996
Echinococcus granulosus g-protein coupled receptor 0.0389 0.1808 0.1808
Echinococcus granulosus histone lysine methyltransferase setb 0.0119 0.0511 0.0511
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0389 0.1808 0.1802
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.003 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0511 0.0501
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0265 0.1213 0.3828
Leishmania major cytochrome p450-like protein 0.0046 0.0156 0.0461
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0389 0.1808 0.1808
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Toxoplasma gondii ABC1 family protein 0.0037 0.0113 0.0339
Schistosoma mansoni neuropeptide receptor 0.0389 0.1808 0.1799
Brugia malayi larval opioid receptor 0.0389 0.1808 0.1802
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0161 0.0161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0389 0.1808 0.1799
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0156 0.0461
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0389 0.1808 0.1808
Echinococcus multilocularis adenylate cyclase type IX 0.0109 0.0462 0.0462
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0161 0.0154
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0665 0.0665
Leishmania major hypothetical protein, conserved 0.0027 0.0069 0.0184
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0107 0.0452 0.0452
Onchocerca volvulus 0.0036 0.0111 0.0099
Plasmodium vivax SET domain protein, putative 0.0119 0.0511 0.1595
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0028 0.0072 0.0583
Onchocerca volvulus 0.0389 0.1808 0.3935
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0452 0.0979
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.003 0.002
Toxoplasma gondii hypothetical protein 0.0047 0.0165 0.0501
Brugia malayi Adenylyl cyclase protein 0.0078 0.031 0.0304
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0041 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1634 0.7798 0.7798
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0113
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0051 0.0082
Leishmania major DNA polymerase eta, putative 0.0019 0.003 0.0062
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0156 0.0156
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0011 0.0000087129
Schistosoma mansoni hypothetical protein 0.0389 0.1808 0.1799
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0028 0.0072 0.0583
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0671 0.3165 0.3165
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0213 0.0652
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0011 0.0011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0389 0.1808 0.1799
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0389 0.1808 0.1808
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0113 0.0974
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.003 0.0062
Echinococcus multilocularis orexin receptor type 2 0.0389 0.1808 0.1808
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1348 0.4238
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.0072 0.0209
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Loa Loa (eye worm) RecQ helicase 0.0022 0.0041 0.0041
Echinococcus granulosus somatostatin receptor 0.0389 0.1808 0.1808
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.004 0.0103
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0265 0.1213 0.2677
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.003 0.003
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0028 0.0072 0.0583
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0389 0.1808 0.1799
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0135 0.0395
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus multilocularis 0.0028 0.0072 0.0072
Echinococcus granulosus 7tm_1 domain containing protein 0.0389 0.1808 0.1808
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0111 0.1303
Schistosoma mansoni DNA polymerase eta 0.0019 0.003 0.002
Brugia malayi Melatonin receptor type 1A 0.0389 0.1808 0.1802
Onchocerca volvulus Neuropeptide F receptor homolog 0.0389 0.1808 0.3935
Echinococcus granulosus dna polymerase eta 0.0019 0.003 0.003
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0164 0.0728 0.1596
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0025 0.0025
Onchocerca volvulus 0.0389 0.1808 0.3935
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0671 0.3165 1
Loa Loa (eye worm) adenylyl cyclase 3 0.0183 0.0819 0.0819
Schistosoma mansoni alpha-1 adrenergic receptor 0.0389 0.1808 0.1799
Brugia malayi AKH receptor 0.0389 0.1808 0.1802
Brugia malayi Serotonin receptor 0.0389 0.1808 0.1802
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Echinococcus granulosus serotonin receptor 0.0389 0.1808 0.1808
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0265 0.1213 0.2677
Brugia malayi hypoxia-induced factor 1 0.0151 0.0665 0.0658
Echinococcus multilocularis fmrfamide receptor 0.0389 0.1808 0.1808
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0389 0.1808 0.1799
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.003 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.003 0.0062
Brugia malayi G protein-coupled receptor 0.0389 0.1808 0.1802
Echinococcus granulosus rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Schistosoma mansoni lamin 0.0027 0.0067 0.0057
Echinococcus multilocularis G protein coupled receptor 139 0.0389 0.1808 0.1808
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0025 0.0139
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus granulosus rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0113 0.0974
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0015
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0025 0.0058
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0119 0.0511 0.0511
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0028 0.0072 0.0713
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.003 0.0023
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.004 0.004
Onchocerca volvulus 0.0078 0.031 0.0549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0113 0.0222
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0389 0.1808 0.1808
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0213 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092
Schistosoma mansoni opsin-like receptor 0.0389 0.1808 0.1799
Schistosoma mansoni hypothetical protein 0.0028 0.0072 0.0062
Onchocerca volvulus 0.0389 0.1808 0.3935
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0011 0.0011
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0107 0.0452 0.0442
Echinococcus granulosus allatostatin A receptor 0.0389 0.1808 0.1808
Schistosoma mansoni biogenic amine (5HT) receptor 0.0389 0.1808 0.1799
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0119 0.0511 0.1597
Echinococcus multilocularis neuropeptides capa receptor 0.0389 0.1808 0.1808
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0028 0.0072 0.0583
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0389 0.1808 0.1808
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0161 0.0161
Toxoplasma gondii hypothetical protein 0.0057 0.0213 0.0655
Toxoplasma gondii exonuclease III APE 0.0018 0.0025 0.006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0113 0.1339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0671 0.3165 1
Echinococcus granulosus bloom syndrome protein 0.0022 0.0041 0.0041
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.004 0.0105
Loa Loa (eye worm) melatonin receptor type 1A 0.0389 0.1808 0.1808
Schistosoma mansoni opsin-like receptor 0.0389 0.1808 0.1799
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1464 0.3238
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0028 0.0072 0.0713
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1464 0.3238
Loa Loa (eye worm) CYP4Cod1 0.0046 0.0156 0.0156
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0028 0.0072 0.0713
Echinococcus granulosus G protein coupled receptor 139 0.0389 0.1808 0.1808
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0028 0.0072 0.0713
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0213 0.0213
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 0.0979
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0511 0.0501
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Mycobacterium ulcerans putative regulatory protein 0.0057 0.0213 0.2857
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.0697 0.1526
Echinococcus granulosus neuropeptide s receptor 0.0389 0.1808 0.1808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.1433 0.1433
Brugia malayi Dopamine receptor protein 1 0.0389 0.1808 0.1802
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 0.1409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1464 0.3238
Schistosoma mansoni neuropeptide receptor 0.0389 0.1808 0.1799
Echinococcus granulosus rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0113 0.0674
Schistosoma mansoni intermediate filament proteins 0.0027 0.0067 0.0057
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus multilocularis rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Leishmania major cytochrome p450-like protein 0.0028 0.0072 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.0697 0.1526
Loa Loa (eye worm) hypothetical protein 0.0164 0.0726 0.0726
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Brugia malayi Cytochrome P450 family protein 0.0046 0.0156 0.0149
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0265 0.1213 0.2677
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0113 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0021
Schistosoma mansoni ran 0.0021 0.004 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0389 0.1808 0.1799
Echinococcus granulosus Solute carrier family 22 5 0.1013 0.4811 0.4811
Loa Loa (eye worm) beta-lactamase 0.0037 0.0113 0.0113
Plasmodium vivax phosphodiesterase gamma, putative 0.0107 0.0452 0.1409
Onchocerca volvulus 0.0389 0.1808 0.3935
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.2091 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0222 0.2996
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0389 0.1808 0.1799
Echinococcus granulosus intermediate filament protein 0.0027 0.0067 0.0067
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0057 0.0213 0.1922
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.003 0.0092
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0107 0.0452 0.0442
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0067 0.0061
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.0683 0.6381
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Echinococcus granulosus peptide allatostatin:somatostatin 0.0389 0.1808 0.1808
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0025 0.0025
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0107 0.0452 0.1399
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0028 0.0072 0.0713
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0028 0.0072 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0213 0.0445
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0072 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092
Echinococcus granulosus alpha 1A adrenergic receptor 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0057 0.0213 0.0213
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.003 0.0062
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0671 0.3165 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0011 0.0011
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0265 0.1213 0.2677
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Brugia malayi sulfakinin receptor protein 0.0389 0.1808 0.1802
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0389 0.1808 0.1808
Echinococcus multilocularis fmrfamide receptor 0.0389 0.1808 0.1808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.004 0.0667
Loa Loa (eye worm) hypothetical protein 0.0078 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0107 0.0452 0.0452
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0011 0.0002
Brugia malayi RNA, U transporter 1 0.0083 0.0336 0.0329
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0107 0.0452 0.0979
Brugia malayi Cytochrome P450 family protein 0.0085 0.0344 0.0338
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0452 0.1425
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0265 0.1213 0.2677
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0222 0.0684
Echinococcus granulosus adenylate cyclase 9 0.0078 0.031 0.031
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0011 0.0011
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0057 0.0213 0.2857
Brugia malayi beta-lactamase 0.0037 0.0113 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0113 0.0326
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0452 0.1399
Echinococcus granulosus rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0135 0.0395
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0072 0.0224
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0452 0.0979
Echinococcus granulosus g protein coupled receptor 0.0389 0.1808 0.1808
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0389 0.1808 0.1808
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0164 0.0728 0.0718
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0025 0.0025
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0265 0.1213 0.1213
Onchocerca volvulus 0.0389 0.1808 0.3935
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Onchocerca volvulus 0.0389 0.1808 0.3935
Schistosoma mansoni neuropeptide F-like receptor 0.0389 0.1808 0.1799
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1464 0.3238
Brugia malayi Dopamine receptor 0.0389 0.1808 0.1802
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0341 0.158 0.1571
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.003 0.0075
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0389 0.1808 0.1808
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.2091 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0389 0.1808 0.1799
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0025 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0119 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus granulosus lamin dm0 0.0027 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus multilocularis g protein coupled receptor 0.0389 0.1808 0.1808
Echinococcus granulosus tm gpcr rhodopsin 0.0389 0.1808 0.1808
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0028 0.0072 0.0713
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.004 0.0123
Echinococcus granulosus dna polymerase kappa 0.0019 0.003 0.003
Echinococcus granulosus g protein coupled receptor 0.0389 0.1808 0.1808
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0011 0.003
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0265 0.1213 0.2677
Toxoplasma gondii hypothetical protein 0.0057 0.0213 0.0655
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0389 0.1808 0.1799
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0028 0.0072 0.0713
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 0.1409
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0046 0.0156 0.1986
Schistosoma mansoni biogenic amine (5HT) receptor 0.0389 0.1808 0.1799
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0041 0.006
Brugia malayi beta-lactamase family protein 0.0037 0.0113 0.0107
Brugia malayi jmjC domain containing protein 0.0057 0.0213 0.0207
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0067 0.0067
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0069 0.1313
Schistosoma mansoni ran 0.0021 0.004 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0213 0.0203
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.1464 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0028 0.0072 0.0713
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0024 0.0051 0.0176
Echinococcus multilocularis g-protein coupled receptor 0.0389 0.1808 0.1808
Echinococcus multilocularis allatostatin A receptor 0.0389 0.1808 0.1808
Onchocerca volvulus 0.0389 0.1808 0.3935
Echinococcus granulosus g protein coupled receptor 0.0389 0.1808 0.1808
Mycobacterium tuberculosis Conserved protein 0.0037 0.0113 0.0974
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0113 0.0974
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0107 0.0452 0.0446
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0076
Trichomonas vaginalis set domain proteins, putative 0.0946 0.4491 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0069 0.1313
Loa Loa (eye worm) hypothetical protein 0.0164 0.0728 0.0728
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0265 0.1213 0.381
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0113 0.0974
Echinococcus multilocularis neuropeptide s receptor 0.0389 0.1808 0.1808
Treponema pallidum fructose-bisphosphate aldolase 0.0317 0.1464 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0028 0.0072 0.0713
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0028 0.0072 0.0713
Trichomonas vaginalis ran, putative 0.0021 0.004 0.0058
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0135 0.0395
Echinococcus granulosus neuropeptide receptor 0.0389 0.1808 0.1808
Echinococcus multilocularis rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0389 0.1808 0.1808
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Mycobacterium ulcerans putative regulatory protein 0.0057 0.0213 0.2857
Brugia malayi beta-lactamase family protein 0.0037 0.0113 0.0107
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0011 0.0004
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0072 0.0195
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0025 0.0025
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0107 0.0452 0.0452
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0051 0.0082
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0107 0.0452 0.0452
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0028 0.0072 0.0583
Echinococcus multilocularis neuropeptide Y receptor 0.0389 0.1808 0.1808
Echinococcus multilocularis rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Echinococcus granulosus single minded 2 0.0036 0.0111 0.0111
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0069 0.0197
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Plasmodium falciparum phosphodiesterase delta, putative 0.0107 0.0452 1
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0213 0.0203
Loa Loa (eye worm) follicle stimulating hormone receptor 0.062 0.292 0.292
Onchocerca volvulus 0.0119 0.0511 0.1003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0119 0.0511 0.0511
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0161 0.0161
Brugia malayi isocitrate dehydrogenase 0.0015 0.0011 0.0004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0113 0.0974
Echinococcus multilocularis rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.003 0.0185
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0077
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 0.0979
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0047
Trypanosoma brucei unspecified product 0.0019 0.003 0.0092
Echinococcus multilocularis adenylate cyclase 9 0.0078 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0222 0.2996
Plasmodium falciparum GAF domain-related protein, putative 0.0057 0.0213 0.4587
Schistosoma mansoni biogenic amine receptor 0.0389 0.1808 0.1799
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0078 0.031 0.0549
Loa Loa (eye worm) G-protein coupled receptor 0.0389 0.1808 0.1808
Onchocerca volvulus 0.0389 0.1808 0.3935
Echinococcus multilocularis neuropeptide receptor 0.0389 0.1808 0.1808
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0028 0.0072 0.0713
Brugia malayi hypothetical protein 0.0027 0.0069 0.0062
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.003 0.002
Echinococcus granulosus hypothetical protein 0.0389 0.1808 0.1808
Mycobacterium ulcerans hypothetical protein 0.0154 0.068 0.9956
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0011 0.003
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0074 0.0295 0.0295
Brugia malayi follicle stimulating hormone receptor 0.062 0.292 0.2915
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Loa Loa (eye worm) G-protein coupled receptor 0.0389 0.1808 0.1808
Plasmodium vivax importin-beta 2, putative 0.0029 0.0077 0.0222
Brugia malayi PAS domain containing protein 0.0049 0.0172 0.0165
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0222 0.0212
Brugia malayi hypothetical protein 0.0164 0.0726 0.072
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0028 0.0072 0.0583
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0028 0.0072 0.0583
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0265 0.1213 0.1213
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0389 0.1808 0.1808
Echinococcus granulosus phd:f box containing protein 0.0015 0.0011 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1464 0.3238
Echinococcus granulosus tm gpcr rhodopsin 0.0389 0.1808 0.1808
Giardia lamblia DINP protein human, muc B family 0.0019 0.003 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0011 0.0011
Schistosoma mansoni amine GPCR 0.0389 0.1808 0.1799
Schistosoma mansoni biogenic amine receptor 0.0389 0.1808 0.1799
Mycobacterium tuberculosis Conserved protein 0.0037 0.0113 0.0974
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0028 0.0072 0.0583
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.1064 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0107 0.0452 0.0446
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0389 0.1808 0.3935
Schistosoma mansoni lamin 0.0027 0.0067 0.0057
Schistosoma mansoni neuropeptide receptor 0.0389 0.1808 0.1799
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.1348 0.4255
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0213 0.0203
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0111 0.0111
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0389 0.1808 0.1808
Schistosoma mansoni adenoreceptor 0.0389 0.1808 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0389 0.1808 0.1799
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0113 0.0222
Echinococcus granulosus neuropeptides capa receptor 0.0389 0.1808 0.1808
Echinococcus multilocularis rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0452 0.0979
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0028 0.0072 0.0713
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.003 0.003
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0107 0.0452 0.0979
Echinococcus multilocularis g protein coupled receptor 0.0389 0.1808 0.1808
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0113 0.0222
Plasmodium falciparum importin beta, putative 0.0029 0.0077 0.1506
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.003 0.0034
Echinococcus granulosus neuropeptide Y receptor 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0389 0.1808 0.1799
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0172 0.0162
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Onchocerca volvulus 0.0389 0.1808 0.3935
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0057 0.0213 0.1922
Schistosoma mansoni neuropeptide receptor 0.0389 0.1808 0.1799
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0028 0.0072 0.0583
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.003 0.0185
Echinococcus granulosus importin subunit beta 1 0.0029 0.0077 0.0077
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0389 0.1808 0.1808
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0011 0.0011
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0107 0.0452 0.0452
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0011 0.003
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0028 0.0072 0.0583
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0265 0.1213 0.3828
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0107 0.0452 0.0452
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0107 0.0452 0.0452
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.003 0.0036
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0069 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.0697 0.1526
Brugia malayi cytochrome P450 0.0028 0.0072 0.0065
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.004 0.004
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0028 0.0072 0.0713
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0107 0.0452 0.0442
Echinococcus granulosus 7TM GPCR rhodopsin 0.0389 0.1808 0.1808
Brugia malayi Serotonin receptor 0.0389 0.1808 0.1802
Echinococcus granulosus rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 0.0979
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0011 0.0011
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0051 0.0127
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0069 0.0184
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0389 0.1808 0.1808
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0107 0.0452 0.1399
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0265 0.1213 0.2677
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.003 0.0023
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0028 0.0072 0.0713
Brugia malayi Importin beta-1 subunit 0.0029 0.0077 0.007
Echinococcus multilocularis g protein coupled receptor 0.0389 0.1808 0.1808
Schistosoma mansoni histamine h1 receptor 0.0389 0.1808 0.1799
Mycobacterium ulcerans beta-lactamase 0.0037 0.0113 0.1339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Giardia lamblia Fructose-bisphosphate aldolase 0.0317 0.1464 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0007 0.0007
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0011 0.0012
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0107 0.0452 0.0442
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0389 0.1808 0.1799
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0078 0.031 0.0549
Entamoeba histolytica Ran family GTPase 0.0021 0.004 0.0103
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0389 0.1808 0.1799
Leishmania major DNA polymerase kappa, putative 0.0019 0.003 0.0062
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0389 0.1808 0.1799
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.003 0.0062
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0389 0.1808 0.1808
Mycobacterium leprae Probable lipase LipE 0.0037 0.0113 0.0674
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0113 0.0354
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0113 0.1339
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0208 0.0936 0.206
Echinococcus multilocularis neuropeptides capa receptor 0.0389 0.1808 0.1808
Echinococcus granulosus neuropeptide FF receptor 2 0.0389 0.1808 0.1808
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0452 0.0979
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0265 0.1213 0.381
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0452 0.1399
Brugia malayi putative neuropeptide receptor 0.0389 0.1808 0.1802
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0113 0.0107
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0028 0.0072 0.0583
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0213 0.0213
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.003 0.0036
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0605 0.1907
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0065
Trichomonas vaginalis esterase, putative 0.0037 0.0113 0.0222
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1348 0.4238
Onchocerca volvulus 0.0389 0.1808 0.3935
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0107 0.0452 0.0442
Schistosoma mansoni amine GPCR 0.0389 0.1808 0.1799
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0107 0.0452 0.0442
Brugia malayi neuropeptide F receptor 0.0389 0.1808 0.1802
Echinococcus multilocularis serotonin receptor 0.0389 0.1808 0.1808
Plasmodium falciparum phosphodiesterase gamma, putative 0.0107 0.0452 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0111 0.0104
Leishmania major cAMP-specific phosphodiesterase, putative 0.0107 0.0452 0.1399
Brugia malayi ORL1-like opioid receptor 0.0389 0.1808 0.1802
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0164 0.0728 0.0722
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0107 0.0452 0.0452
Onchocerca volvulus 0.0074 0.0295 0.0513
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus multilocularis lamin 0.0027 0.0067 0.0067
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0222 0.0222
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0028 0.0072 0.0583
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0025 0.0047
Echinococcus granulosus tachykinin peptides receptor 99D 0.0389 0.1808 0.1808
Giardia lamblia Hypothetical protein 0.0107 0.0452 0.2967
Brugia malayi Dopamine receptor protein 2 0.0389 0.1808 0.1802
Schistosoma mansoni growth hormone secretagogue receptor 0.0389 0.1808 0.1799
Schistosoma mansoni hypothetical protein 0.0389 0.1808 0.1799
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0011 0.0011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0389 0.1808 0.1808
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0389 0.1808 0.1799
Onchocerca volvulus 0.0037 0.0113 0.0104
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Leishmania major GTP-binding protein, putative 0.0021 0.004 0.0093
Loa Loa (eye worm) hypothetical protein 0.0107 0.0452 0.0452
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0107 0.0452 0.0979
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Brugia malayi G protein-coupled receptor F59B2.13 0.0389 0.1808 0.1802
Schistosoma mansoni hypothetical protein 0.0311 0.1433 0.1424
Echinococcus multilocularis snurportin 1 0.0311 0.1433 0.1433
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0389 0.1808 0.1802
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0113
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0265 0.1213 0.2677
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0107 0.0452 0.0442
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0265 0.1213 0.1203
Schistosoma mansoni amine GPCR 0.0389 0.1808 0.1799
Leishmania major hypothetical protein, conserved 0.0107 0.0452 0.1399
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0135 0.0424
Schistosoma mansoni neuropeptide F-like receptor 0.0389 0.1808 0.1799
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0389 0.1808 0.1799
Brugia malayi G-protein coupled receptor 0.0389 0.1808 0.1802
Brugia malayi jmjC domain containing protein 0.0015 0.0011 0.0004
Brugia malayi neuropeptide F receptor 0.0389 0.1808 0.1802
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0107 0.0452 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0028 0.0072 0.0583
Giardia lamblia hypothetical protein 0.0107 0.0452 0.2967
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0072 0.0195
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0028 0.0072 0.0583
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.004 0.0093
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0077 0.0224
Echinococcus granulosus neuropeptides capa receptor 0.0389 0.1808 0.1808
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0011 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0028 0.0072 0.0583
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.004 0.0093
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Brugia malayi jmjC domain containing protein 0.0057 0.0213 0.0207
Schistosoma mansoni opsin-like receptor 0.0389 0.1808 0.1799
Brugia malayi hypothetical protein 0.0018 0.0022 0.0015
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.004 0.0033
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Brugia malayi hypothetical protein 0.0389 0.1808 0.1802
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0389 0.1808 0.1808
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0025 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092
Brugia malayi GnHR receptor homolog 0.0389 0.1808 0.1802
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0107 0.0452 0.0442
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0389 0.1808 0.1799
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0113
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Onchocerca volvulus 0.0389 0.1808 0.3935
Echinococcus multilocularis musashi 0.0027 0.0067 0.0067
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0671 0.3165 0.3165
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0077 0.024
Leishmania major hypothetical protein, conserved 0.0037 0.0113 0.0326
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0161 0.0151
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0028 0.0072 0.0713
Echinococcus granulosus biogenic amine 5HT receptor 0.0389 0.1808 0.1808
Echinococcus multilocularis somatostatin receptor 0.0389 0.1808 0.1808
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0107 0.0452 0.0452
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0028 0.0072 0.0713
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0389 0.1808 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Schistosoma mansoni amine GPCR 0.0389 0.1808 0.1799
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.003
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0164 0.0728 0.0722
Onchocerca volvulus 0.0389 0.1808 0.3935
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0028 0.0072 0.0583
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0452 0.0979
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0265 0.1213 0.2677
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0389 0.1808 0.1799
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0164 0.0728 0.0728
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0011 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0011 0.0011
Mycobacterium ulcerans hypothetical protein 0.0037 0.0113 0.1339
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.004 0.004
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0028 0.0072 0.0713
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0452 0.0979
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0113
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0011 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0452 0.1411
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0265 0.1213 0.2677
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0164 0.0728 0.0728
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0389 0.1808 0.1799
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0832 0.3938 0.3938
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.003 0.003
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0077 0.0077
Onchocerca volvulus 0.0037 0.0113 0.0104
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0011 0.0014
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.004 0.0107
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0265 0.1213 0.2677
Brugia malayi Pre-SET motif family protein 0.0119 0.0511 0.0504
Loa Loa (eye worm) hypothetical protein 0.0389 0.1808 0.1808
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0164 0.0728 0.1596
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0107 0.0452 0.0446
Schistosoma mansoni single-minded 0.0049 0.0172 0.0162
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0113 0.0103
Leishmania major hypothetical protein, conserved 0.0107 0.0452 0.1399
Echinococcus multilocularis geminin 0.0341 0.158 0.158
Brugia malayi jmjC domain containing protein 0.0015 0.0011 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0028 0.0072 0.0583
Echinococcus granulosus rhodopsin orphan GPCR 0.0389 0.1808 0.1808
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.0092

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) 0 ug ml-1 Compound tested in vitro for anti-picornavirus activity against Poliovirus type-2; NA=Not Active ChEMBL. 2989517
MIC (functional) = 3.1 ug ml-1 In vitro anti-picornavirus activity against Rhinovirus type-2. ChEMBL. 2989517
MTL (functional) = 12.5 ug ml-1 Maximum testable level of compound was evaluated ChEMBL. 2989517

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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