Detailed information for compound 30377

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 510.59 | Formula: C28H30N8O2
  • H donors: 3 H acceptors: 6 LogP: 1.9 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(CC(N)(C)C)NC1CCc2c(N(C1=O)Cc1ccc(cc1)c1cccnc1c1n[nH]nn1)cccc2
  • InChi: 1S/C28H30N8O2/c1-28(2,29)16-24(37)31-22-14-13-20-6-3-4-8-23(20)36(27(22)38)17-18-9-11-19(12-10-18)21-7-5-15-30-25(21)26-32-34-35-33-26/h3-12,15,22H,13-14,16-17,29H2,1-2H3,(H,31,37)(H,32,33,34,35)
  • InChiKey: SAKKNUFZKWSMCR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0043 0.0047
Leishmania major cytochrome p450-like protein 0.0046 0.0136 0.0206
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0097 0.0435 0.0448
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0705 0.4038 0.7699
Mycobacterium ulcerans esterase/lipase LipP 0.0031 0.0043 0.0047
Loa Loa (eye worm) hypothetical protein 0.0049 0.0152 0.0204
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0101 0.008
Leishmania major hypothetical protein, conserved 0.0031 0.0043 0.0064
Mycobacterium ulcerans hypothetical protein 0.0031 0.0043 0.0047
Schistosoma mansoni alpha-glucosidase 0.0148 0.0739 0.0774
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0039 0.0022
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0907 0.5235 0.6224
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1444 0.8411 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0051 0.0164 0.0157
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0101 0.008
Onchocerca volvulus 0.007 0.0276 0.0935
Chlamydia trachomatis malate dehydrogenase 0.0907 0.5235 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0276 0.0392
Toxoplasma gondii lactate dehydrogenase LDH2 0.114 0.6612 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0435 0.0633
Echinococcus multilocularis GPCR, family 2 0.0057 0.0197 0.018
Echinococcus multilocularis lamin dm0 0.007 0.0276 0.0259
Brugia malayi lactate dehydrogenase. 0.114 0.6612 1
Schistosoma mansoni retinoic acid receptor RXR 0.0097 0.0435 0.0448
Echinococcus multilocularis dnaJ subfamily B 0.16 0.9337 0.9335
Trypanosoma brucei cytosolic malate dehydrogenase 0.0907 0.5235 1
Echinococcus granulosus geminin 0.0796 0.4573 0.4889
Brugia malayi cytoplasmic intermediate filament protein 0.0038 0.0083 0.0099
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0031 0.0000011646
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0031 0.0043 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0043 0.0051
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0034 0.0005
Brugia malayi beta-lactamase 0.0031 0.0043 0.0038
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Loa Loa (eye worm) hypothetical protein 0.0097 0.0435 0.0633
Brugia malayi hypothetical protein 0.0051 0.0164 0.0222
Schistosoma mansoni survival motor neuron protein 0.0041 0.0104 0.0093
Schistosoma mansoni malate dehydrogenase 0.084 0.4837 0.5172
Brugia malayi Calcitonin receptor-like protein seb-1 0.0179 0.0923 0.1373
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0087 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0034 0.004
Brugia malayi 6-phosphofructokinase 0.0108 0.0501 0.0733
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Trichomonas vaginalis helicase, putative 0.0025 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.0038
Onchocerca volvulus 0.0452 0.2539 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Onchocerca volvulus Bile acid receptor homolog 0.0097 0.0435 0.1574
Loa Loa (eye worm) malate dehydrogenase 0.0907 0.5235 0.7911
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0043 0.0051
Loa Loa (eye worm) hypothetical protein 0.0057 0.0197 0.0272
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.0881 0.1309
Trypanosoma cruzi malate dehydrogenase, putative 0.0661 0.3778 0.7207
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1444 0.8411 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.0031 0.0025
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0051 0.0164 0.0157
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.0031 0.0025
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.0031 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0097 0.0435 0.0633
Schistosoma mansoni hypothetical protein 0.0796 0.4573 0.4889
Schistosoma mansoni ap endonuclease 0.0041 0.0101 0.0089
Plasmodium falciparum importin beta, putative 0.0029 0.0031 0.002
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0501 0.0484
Brugia malayi Cytochrome P450 family protein 0.0067 0.026 0.0367
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0211 0.0194
Echinococcus granulosus beta LACTamase domain containing family member 0.0031 0.0043 0.0027
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0907 0.5235 0.6209
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0097 0.0435 0.0448
Onchocerca volvulus 0.0097 0.0435 0.1574
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0012 0.0014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0164 0.0157
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0501 0.0733
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0097 0.0435 0.0448
Toxoplasma gondii exonuclease III APE 0.0041 0.0101 0.0107
Schistosoma mansoni L-lactate dehydrogenase 0.114 0.6612 0.7076
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0039 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0054
Brugia malayi nuclear hormone receptor 0.0046 0.0132 0.0173
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.0435 0.0633
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0043 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0087 0.0104
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0501 0.0733
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0705 0.4038 0.7699
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.0031 0.0025
Schistosoma mansoni zinc finger protein 0.0046 0.0132 0.0122
Onchocerca volvulus 0.0046 0.0132 0.0358
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0097 0.0435 0.0448
Brugia malayi beta-lactamase family protein 0.0031 0.0043 0.0038
Echinococcus granulosus muscleblind protein 0.0154 0.0775 0.0813
Leishmania major cytosolic malate dehydrogenase 0.0907 0.5235 0.7917
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0501 0.0596
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0031 0.0043 0.0022
Schistosoma mansoni malate dehydrogenase 0.114 0.6612 0.7076
Brugia malayi nuclear receptor RXR 0.0046 0.0132 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0097 0.0435 0.0633
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0087 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.0435 0.0633
Onchocerca volvulus Protein ultraspiracle homolog 0.0097 0.0435 0.1574
Schistosoma mansoni thyroid hormone receptor 0.0097 0.0435 0.0448
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0046 0.0132 0.0114
Echinococcus multilocularis geminin 0.0796 0.4573 0.4564
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.0031 0.0025
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0501 0.0758
Echinococcus granulosus importin subunit beta 1 0.0029 0.0031 0.0014
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0101 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0097 0.0435 0.0633
Mycobacterium leprae Probable lipase LipE 0.0031 0.0043 0.0022
Mycobacterium ulcerans lipase LipD 0.0031 0.0043 0.0047
Mycobacterium tuberculosis Conserved protein 0.0031 0.0043 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0087 0.0104
Brugia malayi RNA, U transporter 1 0.0082 0.0344 0.0495
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0907 0.5235 0.6224
Echinococcus multilocularis nuclear receptor nhr 48 0.0046 0.0132 0.0114
Leishmania major malate dehydrogenase 0.084 0.4837 0.7316
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0179 0.0923 0.1373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0211 0.0208
Loa Loa (eye worm) DR-78 0.0046 0.0132 0.0173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0043 0.0027
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0031 0.0025
Loa Loa (eye worm) glutaminase 2 0.0589 0.335 0.5053
Schistosoma mansoni lamin 0.007 0.0276 0.0277
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0097 0.0435 0.0418
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0051 0.0164 0.0222
Trypanosoma brucei malate dehydrogenase-related 0.0661 0.3778 0.7207
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0031 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0085 0.0367 0.0529
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0196 0.1021 0.1902
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0097 0.0435 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0097 0.0435 0.0633
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.0881 0.1309
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0043 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0097 0.0435 0.0633
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.1674 0.2512
Schistosoma mansoni coup transcription factor 0.0097 0.0435 0.0448
Schistosoma mansoni nuclear receptor nhr-48 0.0046 0.0132 0.0122
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.0031 0.0025
Echinococcus granulosus survival motor neuron protein 1 0.0201 0.1053 0.1111
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0907 0.5235 0.7911
Loa Loa (eye worm) CXXC zinc finger family protein 0.0112 0.0526 0.0771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0097 0.0435 0.0633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0012 0.0014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.0435 0.0418
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0101 0.0089
Schistosoma mansoni mixed-lineage leukemia protein mll 0.024 0.1285 0.1359
Schistosoma mansoni hypothetical protein 0.0041 0.0104 0.0093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0132 0.0114
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0087 0.0064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0097 0.0435 0.0448
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0705 0.4038 0.7705
Echinococcus multilocularis lactate dehydrogenase a 0.114 0.6612 0.6606
Loa Loa (eye worm) hypothetical protein 0.0059 0.0211 0.0293
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0087 0.0105
Echinococcus multilocularis cpg binding protein 0.0119 0.0564 0.0547
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.0031 0.0025
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0501 0.0558
Schistosoma mansoni nuclear receptor 0.0046 0.0132 0.0122
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0046 0.0132 0.0122
Loa Loa (eye worm) hypothetical protein 0.0051 0.0164 0.0222
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0132 0.0122
Schistosoma mansoni L-lactate dehydrogenase 0.0661 0.3778 0.4035
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0101 0.0083
Brugia malayi ecdysteroid receptor 0.0097 0.0435 0.0633
Brugia malayi nuclear receptor RXR 0.0051 0.0164 0.0222
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0101 0.016
Echinococcus granulosus FTZ F1 alpha 0.0097 0.0435 0.0448
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0057 0.0197 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0012 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0031 0.0043 0.0022
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0501 0.0927
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0501 0.0904
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.114 0.6612 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0012 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0085 0.0367 0.0375
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0398 0.2216 0.3333
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0101 0.0126
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.0031 0.0025
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0501 0.0519
Brugia malayi hypothetical protein 0.0046 0.0132 0.0173
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0097 0.0435 0.0418
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0085 0.0367 0.0529
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.0104 0.0131
Loa Loa (eye worm) nuclear receptor NHR-67 0.0046 0.0132 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0097 0.0435 0.0633
Schistosoma mansoni alpha glucosidase 0.0038 0.0087 0.0075
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0087 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0012 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0031 0.0043 0.0022
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0132 0.0114
Schistosoma mansoni RAR-like nuclear receptor 0.0097 0.0435 0.0448
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0087 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0501 0.0596
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.0435 0.0448
Brugia malayi hypothetical protein 0.0051 0.0164 0.0222
Echinococcus granulosus ecdysone induced protein 78C 0.0097 0.0435 0.0448
Mycobacterium tuberculosis Probable esterase LipL 0.0031 0.0043 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0039 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0211 0.0208
Brugia malayi hypothetical protein 0.0046 0.0132 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0012 0.0014
Mycobacterium ulcerans beta-lactamase 0.0031 0.0043 0.0047
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.084 0.4837 0.9238
Brugia malayi Latrophilin receptor protein 2 0.0057 0.0197 0.0272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0211 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0211 0.0208
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.0435 0.0633
Onchocerca volvulus 0.0041 0.0104 0.0247
Schistosoma mansoni nuclear receptor 0.0046 0.0132 0.0122
Mycobacterium tuberculosis Probable hydrolase 0.0031 0.0043 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0164 0.0222
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Schistosoma mansoni steroid hormone receptor ad4bp 0.0097 0.0435 0.0448
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.0031 0.0025
Echinococcus multilocularis lamin 0.007 0.0276 0.0259
Mycobacterium tuberculosis Probable lipase LipE 0.0031 0.0043 0.0022
Toxoplasma gondii lactate dehydrogenase LDH1 0.114 0.6612 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0132 0.0122
Schistosoma mansoni hypothetical protein 0.0306 0.1674 0.1777
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.084 0.4837 0.7308
Plasmodium vivax lactate dehydrogenase 0.114 0.6612 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0012 0.0014
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0661 0.3778 0.5714
Loa Loa (eye worm) steroid hormone receptor 0.0097 0.0435 0.0633
Brugia malayi Pre-SET motif family protein 0.0398 0.2216 0.3333
Toxoplasma gondii histone lysine methyltransferase SET1 0.0215 0.1134 0.1676
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0085 0.0367 0.0375
Brugia malayi Steroid receptor seven-up type 2 0.0097 0.0435 0.0633
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Echinococcus granulosus cytosolic malate dehydrogenase 0.0907 0.5235 0.5598
Echinococcus multilocularis musashi 0.007 0.0276 0.0259
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0087 0.0133
Echinococcus multilocularis muscleblind protein 0.0154 0.0775 0.0759
Schistosoma mansoni hypothetical protein 0.0123 0.0587 0.0611
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0085 0.0367 0.035
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0034 0.0061 0.0047
Schistosoma mansoni hypothetical protein 0.0057 0.0197 0.0192
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Loa Loa (eye worm) hypothetical protein 0.0154 0.0775 0.1149
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0054
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0132 0.0358
Echinococcus granulosus lactate dehydrogenase a 0.114 0.6612 0.7076
Echinococcus granulosus lamin dm0 0.007 0.0276 0.0277
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.0435 0.0633
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0881 0.0865
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0087 0.0133
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0034 0.0005
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0079 0.0093
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Loa Loa (eye worm) malate dehydrogenase 0.084 0.4837 0.7308
Schistosoma mansoni cpg binding protein 0.0119 0.0564 0.0586
Loa Loa (eye worm) beta-lactamase 0.0031 0.0043 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0097 0.0435 0.0633
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0132 0.0122
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0057 0.0197 0.018
Echinococcus granulosus cpg binding protein 0.0119 0.0564 0.0586
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0501 0.0558
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0097 0.0435 0.0633
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0132 0.0173
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.0031 0.0025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0057 0.0197 0.0272
Echinococcus multilocularis L lactate dehydrogenase B chain 0.114 0.6612 0.6606
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0132 0.0114
Plasmodium falciparum L-lactate dehydrogenase 0.114 0.6612 1
Brugia malayi steroid hormone receptor 0.0097 0.0435 0.0633
Mycobacterium tuberculosis Conserved protein 0.0031 0.0043 0.0022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0097 0.0435 0.0448
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0881 0.0865
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0034 0.0025
Trichomonas vaginalis sulfite reductase, putative 0.0026 0.0018 0.0021
Brugia malayi glutaminase DH11.1 0.0589 0.335 0.5053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0097 0.0435 0.0448
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0031 0.0025
Schistosoma mansoni cpg binding protein 0.0119 0.0564 0.0586
Brugia malayi Intermediate filament tail domain containing protein 0.007 0.0276 0.0392
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0079 0.0061
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0087 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1444 0.8411 1
Onchocerca volvulus 0.0046 0.0132 0.0358
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0136 0.0226
Loa Loa (eye worm) hypothetical protein 0.0179 0.0923 0.1373
Schistosoma mansoni ap endonuclease 0.0041 0.0101 0.0089
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.0031 0.0025
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0031 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0087 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Loa Loa (eye worm) hypothetical protein 0.0097 0.0435 0.0633
Brugia malayi orphan nuclear receptor NR2E1 0.0046 0.0132 0.0173
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0057 0.0197 0.0192
Echinococcus granulosus nuclear receptor nhr 48 0.0046 0.0132 0.0122
Loa Loa (eye worm) nuclear hormone receptor 0.0046 0.0132 0.0173
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0034 0.004
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Echinococcus granulosus thyroid hormone receptor alpha 0.0046 0.0132 0.0122
Leishmania major glycosomal malate dehydrogenase 0.084 0.4837 0.7316
Trichomonas vaginalis glutaminase, putative 0.0589 0.335 0.3983
Echinococcus multilocularis malate dehydrogenase 0.084 0.4837 0.4828
Echinococcus multilocularis snurportin 1 0.0306 0.1674 0.1659
Brugia malayi nuclear receptor NHR-88 0.0097 0.0435 0.0633
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0043 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0043 0.0051
Entamoeba histolytica malate dehydrogenase, putative 0.114 0.6612 0.7853
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0101 0.016
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0164 0.0222
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0034 0.0051
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0907 0.5235 1
Brugia malayi ecdysone receptor 0.0046 0.0132 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0012 0.0014
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0046 0.0132 0.0122
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Loa Loa (eye worm) intermediate filament protein 0.007 0.0276 0.0392
Brugia malayi intermediate filament protein 0.007 0.0276 0.0392
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0132 0.0122
Leishmania major cytochrome p450-like protein 0.0029 0.0031 0.0047
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0034 0.0051
Schistosoma mansoni importin beta-1 0.0029 0.0031 0.0014
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.0031 0.0025
Brugia malayi Cytochrome P450 family protein 0.0029 0.0031 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0097 0.0435 0.0448
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0012 0.0014
Schistosoma mansoni cytochrome P450 0.0029 0.0031 0.0014
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0031 0.0014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0097 0.0435 0.0633
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.026 0.0367
Trichomonas vaginalis malate dehydrogenase, putative 0.0322 0.1769 0.2104
Plasmodium vivax importin-beta 2, putative 0.0029 0.0031 0.0047
Plasmodium falciparum lactate dehydrogenase, putative 0.0661 0.3778 0.5702
Loa Loa (eye worm) hypothetical protein 0.0051 0.0164 0.0222
Onchocerca volvulus 0.0059 0.0211 0.0676
Brugia malayi nuclear hormone receptor family member odr-7 0.0046 0.0132 0.0173
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Loa Loa (eye worm) glutaminase 0.0589 0.335 0.5053
Echinococcus granulosus microtubule associated protein 2 0.1165 0.6762 0.7237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0085 0.0367 0.035
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0043 0.0051
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0034 0.004
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0077 0.0089
Treponema pallidum fructose-bisphosphate aldolase 0.1444 0.8411 1
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0907 0.5235 0.5226
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0097 0.0435 0.0448
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0101 0.0153
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0101 0.012
Brugia malayi Pre-SET motif family protein 0.0059 0.0211 0.0293
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0031 0.0025
Loa Loa (eye worm) CYP4Cod1 0.0046 0.0136 0.0179
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0501 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.0435 0.0633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1444 0.8411 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0097 0.0435 0.0633
Loa Loa (eye worm) hypothetical protein 0.0097 0.0435 0.0633
Schistosoma mansoni lamin 0.007 0.0276 0.0277
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0907 0.5235 0.6224
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0101 0.0153
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0043 0.0051
Schistosoma mansoni malate dehydrogenase 0.0907 0.5235 0.5598
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0136 0.0179
Schistosoma mansoni hypothetical protein 0.16 0.9337 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0097 0.0435 0.0418
Schistosoma mansoni nuclear hormone receptor 0.0097 0.0435 0.0448
Echinococcus multilocularis lactate dehydrogenase a 0.114 0.6612 0.6606
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0211 0.0208
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.0038
Brugia malayi phosphofructokinase 0.0108 0.0501 0.0733
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0211 0.0194
Echinococcus granulosus snurportin 1 0.0306 0.1674 0.1777
Brugia malayi cytochrome P450 0.0029 0.0031 0.002
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0152 0.0144
Schistosoma mansoni glutaminase 0.0589 0.335 0.3576
Toxoplasma gondii malate dehydrogenase MDH 0.114 0.6612 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0179 0.0923 0.1373
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0046 0.0132 0.0114
Schistosoma mansoni hypothetical protein 0.0796 0.4573 0.4889
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1444 0.8411 1
Schistosoma mansoni microtubule-associated protein tau 0.1165 0.6762 0.7237
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.084 0.4837 0.9238
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0034 0.0061 0.0044
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0501 0.0558
Trypanosoma brucei glycosomal malate dehydrogenase 0.084 0.4837 0.9238
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0012 0.0014
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0907 0.5235 1
Plasmodium vivax malate dehydrogenase, putative 0.114 0.6612 1
Giardia lamblia Malate dehydrogenase 0.0907 0.5235 0.6224
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0097 0.0435 0.0448
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.0435 0.0418
Schistosoma mansoni hypothetical protein 0.0057 0.0197 0.0192
Loa Loa (eye worm) hypothetical protein 0.0123 0.0587 0.0863
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0046 0.0132 0.0173
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0031 0.0043 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0501 0.0596
Loa Loa (eye worm) hypothetical protein 0.0097 0.0435 0.0633
Echinococcus granulosus L lactate dehydrogenase 0.0479 0.2695 0.2873
Schistosoma mansoni hypothetical protein 0.0029 0.0031 0.0014
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0501 0.0904
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0085 0.0367 0.0375
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.0031 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1444 0.8411 1
Brugia malayi nuclear hormone receptor 0.0097 0.0435 0.0633
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0034 0.004
Echinococcus multilocularis lactate dehydrogenase protein 0.114 0.6612 0.6606
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0055 0.0184 0.0179
Loa Loa (eye worm) cytochrome P450 0.0029 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0097 0.0435 0.0633
Loa Loa (eye worm) hypothetical protein 0.0034 0.0061 0.0066
Brugia malayi hypothetical protein 0.0201 0.1053 0.157
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0031 0.0043 0.0038
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0097 0.0435 0.0418
Echinococcus granulosus intermediate filament protein 0.007 0.0276 0.0277
Echinococcus multilocularis ecdysone induced protein 78C 0.0097 0.0435 0.0418
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0012 0.0014
Toxoplasma gondii ABC1 family protein 0.0031 0.0043 0.0018
Echinococcus multilocularis lactate dehydrogenase a 0.114 0.6612 0.6606
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.007 0.0276 0.0392
Trichomonas vaginalis malate dehydrogenase, putative 0.0568 0.3226 0.3836
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0097 0.0435 0.0418
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0057 0.0197 0.0192
Brugia malayi conserved hypotetical protein 0.0046 0.0132 0.0173
Brugia malayi Muscleblind-like protein 0.0154 0.0775 0.1149
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0046 0.0136 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.0435 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0043 0.0047
Echinococcus granulosus malate dehydrogenase 0.084 0.4837 0.5172
Onchocerca volvulus 0.01 0.0451 0.1636
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0101 0.0126
Trypanosoma brucei cytochrome P450, putative 0.0046 0.0136 0.0226
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.0031 0.0025
Echinococcus granulosus dnaJ subfamily B 0.16 0.9337 1
Echinococcus multilocularis 0.0029 0.0031 0.0013
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0907 0.5235 0.6224
Brugia malayi nuclear hormone receptor family member nhr-6 0.0046 0.0132 0.0173
Schistosoma mansoni cpg binding protein 0.0112 0.0526 0.0546
Loa Loa (eye worm) hypothetical protein 0.0051 0.0164 0.0222
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0031 0.0025
Brugia malayi tailless protein 0.0046 0.0132 0.0173
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0101 0.0135
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0031 0.0025
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0034 0.004
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0046 0.0132 0.0122
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0501 0.0558
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0087 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0501 0.0596
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0034 0.0025
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0026 0.0018 0.0027
Echinococcus granulosus cytosolic malate dehydrogenase 0.0907 0.5235 0.5598
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0775 0.0759
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0034 0.004
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.0031 0.0025
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0039 0.0022
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.0881 0.0926
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1444 0.8411 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0097 0.0435 0.0633
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0132 0.0358
Brugia malayi nuclear receptor NHR-67 0.0046 0.0132 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0012 0.0014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0087 0.0104
Trypanosoma brucei glucosidase, putative 0.0038 0.0087 0.0133
Trypanosoma brucei mitochondrial malate dehydrogenase 0.084 0.4837 0.9238
Giardia lamblia Fructose-bisphosphate aldolase 0.1444 0.8411 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0097 0.0435 0.0633
Echinococcus multilocularis beta LACTamase domain containing family member 0.0031 0.0043 0.0025
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0031 0.0047
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0034 0.0005
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0051 0.0164 0.0147
Echinococcus multilocularis L lactate dehydrogenase 0.0479 0.2695 0.2682
Loa Loa (eye worm) hypothetical protein 0.0201 0.1053 0.157
Schistosoma mansoni hypothetical protein 0.0057 0.0197 0.0192
Brugia malayi 6-phosphofructokinase 0.0108 0.0501 0.0733
Echinococcus granulosus malate dehydrogenase 0.084 0.4837 0.5172
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0012 0.0014
Leishmania major malate dehydrogenase, putative 0.0661 0.3778 0.5714
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0085 0.0367 0.0375
Brugia malayi Importin beta-1 subunit 0.0029 0.0031 0.002
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0501 0.0733
Brugia malayi CXXC zinc finger family protein 0.0112 0.0526 0.0771
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0211 0.0274
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0501 0.0519
Loa Loa (eye worm) hypothetical protein 0.0097 0.0435 0.0633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0097 0.0435 0.0633
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Echinococcus multilocularis malate dehydrogenase 0.084 0.4837 0.4828
Echinococcus granulosus tumor protein p63 0.0336 0.1851 0.1968
Echinococcus multilocularis FTZ F1 alpha 0.0097 0.0435 0.0418
Brugia malayi Cytochrome P450 family protein 0.0046 0.0136 0.0179
Loa Loa (eye worm) hypothetical protein 0.0051 0.0164 0.0222
Echinococcus multilocularis tumor protein p63 0.0336 0.1851 0.1837
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.0435 0.0633
Echinococcus granulosus GPCR family 2 0.0057 0.0197 0.0192
Schistosoma mansoni alpha-glucosidase 0.0148 0.0739 0.0774
Trypanosoma cruzi malate dehydrogenase, putative 0.084 0.4837 0.9238
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0501 0.0519
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0038 0.0083 0.0099
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1444 0.8411 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Onchocerca volvulus 0.007 0.0276 0.0935
Brugia malayi nuclear receptor NHR-88 0.0046 0.0132 0.0173
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0907 0.5235 1
Entamoeba histolytica malate dehydrogenase, putative 0.0907 0.5235 0.6209
Loa Loa (eye worm) latrophilin receptor protein 2 0.0057 0.0197 0.0272
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.084 0.4837 0.9238
Loa Loa (eye worm) hypothetical protein 0.114 0.6612 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0435 0.0633
Loa Loa (eye worm) hypothetical protein 0.0154 0.0775 0.1149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.0435 0.0448
Brugia malayi beta-lactamase family protein 0.0031 0.0043 0.0038
Onchocerca volvulus 0.0049 0.0152 0.044
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0097 0.0435 0.1574
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0136 0.0179
Onchocerca volvulus 0.0112 0.0526 0.1938
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0101 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0043 0.0047
Leishmania major mitochondrial malate dehydrogenase 0.084 0.4837 0.7316
Mycobacterium ulcerans malate dehydrogenase 0.0907 0.5235 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0132 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0085 0.0367 0.0375
Leishmania major p450 reductase, putative 0.0026 0.0018 0.0027
Echinococcus granulosus lactate dehydrogenase protein 0.114 0.6612 0.7076
Mycobacterium tuberculosis Conserved protein 0.0031 0.0043 0.0022
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.0031 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0087 0.0104
Loa Loa (eye worm) hypothetical protein 0.0069 0.0269 0.038
Echinococcus granulosus lamin 0.007 0.0276 0.0277
Schistosoma mansoni malate dehydrogenase 0.0907 0.5235 0.5598
Echinococcus granulosus L lactate dehydrogenase B chain 0.114 0.6612 0.7076
Brugia malayi latrophilin 2 splice variant baaae 0.0123 0.0587 0.0863
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0034 0.004
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0039 0.0021
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0101 0.016
Echinococcus multilocularis microtubule associated protein 2 0.1165 0.6762 0.6756
Trichomonas vaginalis esterase, putative 0.0031 0.0043 0.0051
Schistosoma mansoni thyroid hormone receptor 0.0097 0.0435 0.0448
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0034 0.004
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.0031 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0132 0.0122
Brugia malayi Cytochrome P450 family protein 0.0046 0.0136 0.0179
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0012 0.0014
Leishmania major cytochrome p450-like protein 0.0029 0.0031 0.0047
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0087 0.0132
Schistosoma mansoni hypothetical protein 0.0057 0.0197 0.0192
Plasmodium vivax SET domain protein, putative 0.0059 0.0211 0.0319
Trichomonas vaginalis malate dehydrogenase, putative 0.0661 0.3778 0.4492
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0136 0.0226
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0907 0.5235 0.5226
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0031 0.0043 0.0038
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0046 0.0132 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0012 0.0014
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0501 0.0927
Plasmodium falciparum malate dehydrogenase 0.114 0.6612 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0079 0.0066
Trichomonas vaginalis malate dehydrogenase, putative 0.0907 0.5235 0.6224
Schistosoma mansoni intermediate filament proteins 0.007 0.0276 0.0277
Mycobacterium ulcerans glutaminase 0.0589 0.335 0.6387
Leishmania major malate dehydrogenase, putative 0.114 0.6612 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0101 0.0126
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0087 0.0064
Echinococcus granulosus lactate dehydrogenase a 0.114 0.6612 0.7076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.0038
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0087 0.0105
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0907 0.5235 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0164 0.0222
Trichomonas vaginalis set domain proteins, putative 0.0452 0.2539 0.3019
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0132 0.0173
Echinococcus multilocularis survival motor neuron protein 1 0.0201 0.1053 0.1037
Brugia malayi photoreceptor-specific nuclear receptor 0.0097 0.0435 0.0633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1444 0.8411 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0087 0.0104
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1444 0.8411 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0026 0.0018 0.0027

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2350 nM The compound was tested in vitro for the growth hormone release in rat pituitary cell assays ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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