Detailed information for compound 314021

Basic information

Technical information
  • TDR Targets ID: 314021
  • Name: 5-[[methyl(phenethyl)amino]methyl]-N-(2,4,6-t richlorophenyl)-4-(trifluoromethyl)-1,3-thiaz ol-2-amine
  • MW: 494.788 | Formula: C20H17Cl3F3N3S
  • H donors: 1 H acceptors: 1 LogP: 7.46 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1sc(nc1C(F)(F)F)Nc1c(Cl)cc(cc1Cl)Cl)CCc1ccccc1
  • InChi: 1S/C20H17Cl3F3N3S/c1-29(8-7-12-5-3-2-4-6-12)11-16-18(20(24,25)26)28-19(30-16)27-17-14(22)9-13(21)10-15(17)23/h2-6,9-10H,7-8,11H2,1H3,(H,27,28)
  • InChiKey: IRLIASOPYFRZMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[methyl(phenethyl)amino]methyl]-N-(2,4,6-trichlorophenyl)-4-(trifluoromethyl)thiazol-2-amine
  • 5-[[methyl(phenethyl)amino]methyl]-N-(2,4,6-trichlorophenyl)-4-(trifluoromethyl)-2-thiazolamine
  • methyl-phenethyl-[[2-(2,4,6-trichloroanilino)-4-(trifluoromethyl)thiazol-5-yl]methyl]amine
  • 5-[(methyl-(2-phenylethyl)amino)methyl]-N-(2,4,6-trichlorophenyl)-4-(trifluoromethyl)-1,3-thiazol-2-amine
  • 5-[(methyl-(2-phenylethyl)amino)methyl]-N-(2,4,6-trichlorophenyl)-4-(trifluoromethyl)thiazol-2-amine
  • 5-[(methyl-(2-phenylethyl)amino)methyl]-N-(2,4,6-trichlorophenyl)-4-(trifluoromethyl)-2-thiazolamine
  • methyl-(2-phenylethyl)-[[2-[(2,4,6-trichlorophenyl)amino]-4-(trifluoromethyl)thiazol-5-yl]methyl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 1 444 aa 445 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.0129 0.0129
Plasmodium falciparum kelch protein K13 0.005 0.0134 0.3112
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0111 0.0327 0.059
Echinococcus multilocularis BC026374 protein (S09 family) 0.0293 0.0915 0.0915
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0026 0.0055 0.1272
Loa Loa (eye worm) voltage-gated calcium channel 0.0046 0.0119 0.0119
Entamoeba histolytica phosphofructokinase, putative 0.0032 0.0074 0.1716
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0019 0.0034 0.0061
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0344 0.1077 0.1077
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0046 0.0119 0.3083
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0047 0.0432
Schistosoma mansoni voltage-dependent calcium channel 0.0046 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0011 0.0007 0.0139
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0014 0.0018 0.04
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0025 0.0025
Brugia malayi Carboxylesterase family protein 0.1737 0.5553 1
Echinococcus granulosus expressed conserved protein 0.0041 0.0105 0.0105
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0046 0.0119 0.0119
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0046 0.0119 0.0119
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0111 0.0327 0.059
Schistosoma mansoni hypothetical protein 0.312 1 1
Entamoeba histolytica DNA topoisomerase III, putative 0.0014 0.0018 0.04
Schistosoma mansoni glutamate receptor AMPA 0.002 0.0035 0.0035
Schistosoma mansoni twik family of potassium channels-related 0.0111 0.0327 0.0327
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.005 0.0134 0.0134
Leishmania major hypothetical protein, unknown function 0.0046 0.0119 0.3083
Echinococcus granulosus voltage dependent calcium channel 0.0046 0.0119 0.0119
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0008 0.018
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0025 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0097 0.0097
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0014 0.0018 0.0018
Trypanosoma brucei potassium voltage-gated channel, putative 0.005 0.0134 0.3487
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0032 0.0074 1
Echinococcus granulosus lamin 0.0011 0.0007 0.0007
Trypanosoma cruzi potassium voltage-gated channel, putative 0.005 0.0134 0.3487
Echinococcus granulosus sodium channel protein 0.0076 0.0217 0.0217
Echinococcus granulosus potassium voltage gated channel subfamily A 0.1155 0.3682 0.3682
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0112 0.0331 0.8649
Plasmodium falciparum basic transcription factor 3b, putative 0.001 0.0005 0.0094
Onchocerca volvulus 0.0293 0.0915 1
Echinococcus granulosus TRP transient receptor potential channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.1155 0.3682 0.3682
Echinococcus multilocularis calcium activated potassium channel variant 0.0111 0.0327 0.0327
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0097 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Echinococcus granulosus BC026374 protein S09 family 0.0293 0.0915 0.0915
Schistosoma mansoni hypothetical protein 0.0046 0.0119 0.0119
Onchocerca volvulus 0.005 0.0134 0.1442
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0119 0.0119
Brugia malayi Pre-SET motif family protein 0.0062 0.017 0.0306
Entamoeba histolytica DNA topoisomerase II, putative 0.0142 0.0428 1
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0014 0.0018 0.0018
Echinococcus granulosus potassium voltage gated channel protein 0.0046 0.0119 0.0119
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Brugia malayi GRF zinc finger family protein 0.0014 0.0018 0.0032
Echinococcus multilocularis hyperpolarization activated cyclic 0.0046 0.0119 0.0119
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0055 0.1277
Loa Loa (eye worm) hypothetical protein 0.003 0.007 0.007
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0111 0.0327 0.059
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.1104 0.3521 0.3521
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0008 0.018
Loa Loa (eye worm) glutamate receptor 1 0.002 0.0035 0.0035
Leishmania major DNA topoisomerase III, putative 0.0014 0.0018 0.0448
Schistosoma mansoni BC026374 protein (S09 family) 0.0293 0.0915 0.0915
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0076 0.0217 0.0217
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0076 0.0217 0.5659
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0026 0.0055 0.3578
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0046 0.0121 0.0121
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0011 0.0007 0.0155
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0022 0.004
Schistosoma mansoni voltage-gated ion channel 0.0046 0.0119 0.0119
Echinococcus multilocularis acetylcholinesterase 0.1737 0.5553 0.5553
Echinococcus multilocularis protein dispatched 1 0.0022 0.0042 0.0042
Echinococcus multilocularis dna polymerase eta 0.0023 0.0046 0.0046
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0025 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0033 0.006
Echinococcus granulosus tumor protein p63 0.0164 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Echinococcus multilocularis two pore calcium channel protein 1 0.0046 0.0119 0.0119
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0009 0.0002 0.0031
Echinococcus granulosus nmda type glutamate receptor 0.0046 0.0119 0.0119
Echinococcus multilocularis twik family of potassium channels 0.0111 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Onchocerca volvulus 0.005 0.0134 0.1442
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) TWK-28 protein 0.0111 0.0327 0.0327
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0022 0.0022
Leishmania major DNA topoisomerase 1A 0.0014 0.0018 0.0448
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0111 0.0327 0.059
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0802
Echinococcus granulosus sterol regulatory element binding protein 0.0019 0.0033 0.0033
Echinococcus multilocularis potassium channel subfamily K 8 0.0111 0.0327 0.0327
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0025 0.0025
Plasmodium falciparum DNA gyrase subunit A 0.0026 0.0055 0.1272
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0046 0.0119 0.3083
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0106 0.2767
Schistosoma mansoni glutamate receptor NMDA 0.0046 0.0121 0.0121
Schistosoma mansoni glutamate receptor kainate 0.002 0.0035 0.0035
Echinococcus granulosus microtubule associated protein 2 0.0636 0.2017 0.2017
Echinococcus multilocularis expressed conserved protein 0.0041 0.0105 0.0105
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0096 0.028 0.028
Plasmodium falciparum DNA gyrase subunit B 0.0047 0.0122 0.2838
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0025 0.0045
Mycobacterium tuberculosis Carboxylesterase LipT 0.0293 0.0915 1
Leishmania major DNA polymerase kappa, putative 0.0017 0.0028 0.0715
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0198 0.0609 0.0609
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0111 0.0327 0.0327
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0047 0.0047
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.005 0.0134 0.0134
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.028 0.028
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0022 0.0022
Echinococcus granulosus twik family of potassium channels 0.0111 0.0327 0.0327
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.005 0.0134 0.0134
Plasmodium vivax DNA gyrase subunit B, putative 0.0047 0.0122 0.2838
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0111 0.0327 0.059
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0293 0.0915 0.0915
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.1155 0.3682 0.3682
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.0628 0.0628
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0025 0.0248
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0134 0.0134
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0012 0.0248
Loa Loa (eye worm) hypothetical protein 0.0245 0.0761 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0025 0.0045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.0761 0.137
Onchocerca volvulus 0.005 0.0134 0.1442
Trypanosoma cruzi DNA topoisomerase III, putative 0.0014 0.0018 0.0448
Loa Loa (eye worm) hypothetical protein 0.0095 0.0278 0.0278
Brugia malayi mKIAA0176 protein 0.005 0.0134 0.0241
Loa Loa (eye worm) hypothetical protein 0.1737 0.5553 0.5553
Echinococcus multilocularis shaker cognate 0.0096 0.028 0.028
Entamoeba histolytica hypothetical protein 0.0029 0.0065 0.1501
Echinococcus granulosus 6 phosphofructokinase 0.0032 0.0074 0.0074
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0128 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0222 0.0687 0.0687
Giardia lamblia DINP protein human, muc B family 0.0017 0.0028 0.0669
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0111 0.0327 0.8564
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.002 0.0038 0.0038
Echinococcus granulosus BTB:POZ domain containing protein 0.005 0.0134 0.0134
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0025 0.0045
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0055 0.1277
Plasmodium vivax potassium channel, putative 0.0111 0.0327 0.7644
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0041 0.1045
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.005 0.0134 0.3112
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0111 0.0327 0.059
Brugia malayi Transient-receptor-potential like protein 0.0046 0.0119 0.0213
Loa Loa (eye worm) intermediate filament protein 0.0011 0.0007 0.0007
Brugia malayi Cytochrome P450 family protein 0.0025 0.0054 0.0097
Trypanosoma cruzi ion transport protein, putative 0.0111 0.0327 0.8564
Brugia malayi hypothetical protein 0.0111 0.0327 0.059
Schistosoma mansoni lamin 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Loa Loa (eye worm) MH2 domain-containing protein 0.0054 0.0144 0.0144
Echinococcus multilocularis potassium channel subfamily K 0.0111 0.0327 0.0327
Echinococcus granulosus hyperpolarization activated cyclic 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.0033
Echinococcus granulosus acetylcholinesterase 0.1737 0.5553 0.5553
Onchocerca volvulus 0.0024 0.0049 0.0513
Echinococcus multilocularis twik family of potassium channels 0.0111 0.0327 0.0327
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0008 0.0008
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0025 0.0025
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0046 0.0119 0.0119
Trypanosoma brucei unspecified product 0.0011 0.0007 0.0146
Echinococcus multilocularis protein patched 0.0019 0.0033 0.0033
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.0119 0.0213
Echinococcus multilocularis transient receptor potential cation channel 0.0046 0.0119 0.0119
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0025 0.0025
Brugia malayi DNA topoisomerase III beta-1 0.0014 0.0018 0.0032
Leishmania major DNA polymerase eta, putative 0.0023 0.0046 0.118
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0025 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.002 0.0038 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Echinococcus multilocularis voltage dependent calcium channel 0.0046 0.0119 0.0119
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0012 0.0278
Echinococcus granulosus shaker cognate 0.0096 0.028 0.028
Schistosoma mansoni calcium-activated potassium channel 0.2157 0.6905 0.6905
Brugia malayi Muscleblind-like protein 0.0222 0.0687 0.1237
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0046 0.0119 0.1273
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Brugia malayi 6-phosphofructokinase 0.0032 0.0074 0.0134
Mycobacterium ulcerans DNA gyrase subunit B 0.0047 0.0122 0.126
Trypanosoma cruzi DNA topoisomerase III, putative 0.0014 0.0018 0.0448
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0046 0.0119 0.0213
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0031
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Schistosoma mansoni transient receptor potential channel 0.0046 0.0119 0.0119
Echinococcus multilocularis transient receptor potential cation channel 0.0046 0.0119 0.0119
Schistosoma mansoni lamin 0.0011 0.0007 0.0007
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0046 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0046 0.0119 0.0119
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0025 0.0025
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0047 0.0122 0.2838
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.005 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Trypanosoma brucei DNA topoisomerase III, putative 0.0014 0.0018 0.0448
Echinococcus multilocularis para nitrobenzyl esterase 0.0293 0.0915 0.0915
Toxoplasma gondii ion channel protein 0.0111 0.0327 0.7644
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0014 0.0018 0.0448
Mycobacterium ulcerans carboxylesterase, LipT 0.0293 0.0915 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0106 0.2767
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0111 0.0327 0.8564
Echinococcus granulosus ryanodine receptor 44f 0.0046 0.0119 0.0119
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0046 0.0119 0.3083
Echinococcus granulosus intermediate filament protein 0.0011 0.0007 0.0007
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0111 0.0327 0.8564
Echinococcus multilocularis sterol regulatory element binding protein 0.0019 0.0033 0.0033
Brugia malayi hypothetical protein 0.0046 0.0119 0.0213
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0111 0.0327 0.059
Echinococcus granulosus potassium voltage gated channel protein 0.0046 0.0119 0.0119
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0134 0.0134
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0011 0.0007 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.028 0.028
Trypanosoma brucei DNA topoisomerase ii 0.0112 0.0331 0.8649
Brugia malayi ecdysteroid receptor 0.0016 0.0025 0.0045
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0088 0.0256 0.6687
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.001 0.001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0009 0.0002 0.0002
Echinococcus multilocularis potassium voltage gated channel protein 0.1155 0.3682 0.3682
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0119 0.0119
Echinococcus multilocularis glutamate receptor NMDA 0.0038 0.0096 0.0096
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0014 0.0018 0.0018
Onchocerca volvulus 0.0011 0.0007 0.0049
Onchocerca volvulus Huntingtin homolog 0.0049 0.0129 0.1392
Brugia malayi hypothetical protein 0.0293 0.0915 0.1648
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0069 0.0069
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0046 0.0119 0.0119
Schistosoma mansoni calcium-activated potassium channel 0.312 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0044 0.0114 0.0114
Echinococcus granulosus sodium leak channel non selective protein 0.0046 0.0119 0.0119
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0028 0.0715
Echinococcus granulosus glutamate receptor 2 0.0023 0.0047 0.0047
Echinococcus multilocularis transient receptor potential cation channel 0.0046 0.0119 0.0119
Leishmania major potassium channel subunit-like protein 0.0111 0.0327 0.8564
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0046 0.0119 0.2752
Echinococcus multilocularis muscleblind protein 0.0222 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0025 0.0025
Schistosoma mansoni edp1-related 0.005 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.102 0.3251 0.3251
Leishmania major hypothetical protein, conserved 0.0026 0.0055 0.1431
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0055 0.1277
Schistosoma mansoni voltage-gated cation channel 0.0046 0.0119 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0025 0.0045
Plasmodium vivax potassium channel, putative 0.0111 0.0327 0.7644
Echinococcus granulosus glutamate receptor 2 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.1737 0.5553 0.5553
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0046 0.0119 0.0119
Schistosoma mansoni survival motor neuron protein 0.0019 0.0034 0.0034
Echinococcus multilocularis transfer RNA-Gly 0.0096 0.028 0.028
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0005 0.0044
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0103 0.0303 0.3291
Schistosoma mansoni hypothetical protein 0.0019 0.0034 0.0034
Echinococcus granulosus survival motor neuron protein 1 0.0094 0.0276 0.0276
Leishmania major calcium/potassium channel (CAKC), putative 0.0111 0.0327 0.8564
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0011 0.0007 0.0007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Brugia malayi polk-prov protein 0.0013 0.0013 0.0023
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0119 0.1286
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0025 0.0025
Loa Loa (eye worm) TWK-7 protein 0.0111 0.0327 0.0327
Echinococcus multilocularis nmda type glutamate receptor 0.0042 0.0107 0.0107
Schistosoma mansoni twik family of potassium channels-related 0.0111 0.0327 0.0327
Schistosoma mansoni potassium channel tetramerization domain-containing 0.005 0.0134 0.0134
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0047 0.0047
Echinococcus granulosus calcium activated potassium channel variant 0.0111 0.0327 0.0327
Loa Loa (eye worm) voltage-gated potassium channel 0.0096 0.028 0.028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0025 0.0045
Echinococcus multilocularis glutamate receptor 2 0.0016 0.0024 0.0024
Echinococcus granulosus neuroligin 0.0293 0.0915 0.0915
Loa Loa (eye worm) hypothetical protein 0.0293 0.0915 0.0915
Brugia malayi Carboxylesterase family protein 0.0293 0.0915 0.1648
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0025 0.0025
Echinococcus granulosus ubiquitin specific protease 41 0.0011 0.0007 0.0007
Loa Loa (eye worm) voltage-gated potassium channel 0.0046 0.0119 0.0119
Onchocerca volvulus 0.0111 0.0327 0.3562
Echinococcus granulosus potassium channel subfamily K 8 0.0111 0.0327 0.0327
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0103 0.0303 0.3291
Toxoplasma gondii DNA topoisomerase family protein 0.0014 0.0018 0.04
Onchocerca volvulus 0.0111 0.0327 0.3562
Echinococcus multilocularis transient receptor potential cation channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0049 0.0129 0.0129
Brugia malayi Intermediate filament tail domain containing protein 0.0011 0.0007 0.0012
Echinococcus multilocularis potassium voltage gated channel protein 0.0046 0.0119 0.0119
Schistosoma mansoni twik family of potassium channels-related 0.0111 0.0327 0.0327
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0293 0.0915 0.0915
Brugia malayi follicle stimulating hormone receptor 0.0113 0.0335 0.0604
Trypanosoma cruzi btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Echinococcus granulosus nmda type glutamate receptor 0.0042 0.0107 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0111 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Onchocerca volvulus 0.0111 0.0327 0.3562
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0293 0.0915 0.0915
Onchocerca volvulus 0.0111 0.0327 0.3562
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0062 0.017 0.017
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0014 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0039 0.0097 0.2243
Echinococcus multilocularis muscleblind protein 1 0.0222 0.0687 0.0687
Onchocerca volvulus 0.0111 0.0327 0.3562
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Echinococcus granulosus dnaJ subfamily B 0.0198 0.0609 0.0609
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1737 0.5553 0.5553
Plasmodium vivax DNA topoisomerase 3, putative 0.0014 0.0018 0.04
Echinococcus granulosus acetylcholinesterase 0.1737 0.5553 0.5553
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0142 0.0428 0.0771
Brugia malayi Pre-SET motif family protein 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0049
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0111 0.0327 0.0327
Loa Loa (eye worm) carboxylesterase 0.1737 0.5553 0.5553
Echinococcus granulosus potassium channel subfamily K 8 0.0111 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Onchocerca volvulus 0.005 0.0134 0.1442
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0047 0.0047
Brugia malayi Cyclic-nucleotide gated cation channel 0.0046 0.0119 0.0213
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0166 0.0166
Loa Loa (eye worm) voltage-dependent calcium channel 0.0046 0.0119 0.0119
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0047 0.0503
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0047 0.0047
Echinococcus granulosus calcium activated potassium channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.312 1 1
Schistosoma mansoni cellular tumor antigen P53 0.0024 0.0049 0.0049
Brugia malayi Carboxylesterase family protein 0.0293 0.0915 0.1648
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0047 0.0122 0.1121
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0046 0.0119 0.0119
Schistosoma mansoni transient receptor potential channel 0.0046 0.0119 0.0119
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0293 0.0915 1
Loa Loa (eye worm) hypothetical protein 0.003 0.007 0.007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0011 0.0007 0.0065
Brugia malayi hypothetical protein 0.0094 0.0276 0.0496
Echinococcus granulosus potassium voltage gated channel protein 0.0096 0.028 0.028
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0047 0.0122 1
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.005 0.0134 0.3112
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0033
Loa Loa (eye worm) 6-phosphofructokinase 0.0032 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0063 0.0174 0.0174
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.005 0.0134 0.3112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0002 0.0002
Leishmania major DNA topoisomerase ii 0.0128 0.0382 1
Onchocerca volvulus 0.0014 0.0018 0.0172
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0046 0.0119 0.0213
Echinococcus granulosus Small ubiquitin modifier 2 0.0009 0.0001 0.0001
Echinococcus granulosus lamin dm0 0.0011 0.0007 0.0007
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0111 0.0327 0.059
Echinococcus multilocularis voltage gated potassium channel 0.0096 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0293 0.0915 0.0915
Echinococcus multilocularis GPCR, family 2 0.0019 0.0033 0.0033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0025 0.0025
Loa Loa (eye worm) ion channel NompC 0.0046 0.0119 0.0119
Brugia malayi Carboxylesterase family protein 0.1737 0.5553 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0046 0.0119 0.0119
Echinococcus multilocularis calcium activated potassium channel 0.0046 0.0119 0.0119
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0096 0.028 0.028
Echinococcus granulosus carboxylesterase 5A 0.1737 0.5553 0.5553
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0112 0.0331 0.8649
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0025 0.0045
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0033
Echinococcus granulosus transient receptor potential cation channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0094 0.0276 0.0276
Chlamydia trachomatis DNA gyrase subunit B 0.0077 0.022 1
Trypanosoma cruzi btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.005 0.0134 0.3487
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0022 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0025 0.0025
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0046 0.0119 0.0119
Brugia malayi hypothetical protein 0.0039 0.0097 0.0174
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0011 0.0007 0.0155
Echinococcus granulosus voltage gated potassium channel 0.0046 0.0119 0.0119
Echinococcus multilocularis lamin 0.0011 0.0007 0.0007
Trichomonas vaginalis set domain proteins, putative 0.007 0.0197 0.2143
Entamoeba histolytica DNA topoisomerase III, putative 0.0014 0.0018 0.04
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0025 0.0025
Schistosoma mansoni calcium-activated potassium channel 0.0046 0.0119 0.0119
Echinococcus multilocularis potassium large conductance calcium activated 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Entamoeba histolytica hypothetical protein 0.0039 0.0097 0.2243
Trypanosoma cruzi ion transport protein, putative 0.0111 0.0327 0.8564
Echinococcus multilocularis transcription factor btf3 0.001 0.0005 0.0005
Giardia lamblia DNA topoisomerase III 0.0014 0.0018 0.0419
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0046 0.0119 0.0119
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0046 0.0119 0.0119
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0012 0.0012 0.0291
Echinococcus multilocularis ubiquitin specific protease 41 0.0011 0.0007 0.0007
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0046 0.118
Echinococcus granulosus voltage dependent calcium channel 0.0046 0.0119 0.0119
Toxoplasma gondii transporter, cation channel family protein 0.0046 0.0119 0.2752
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0046 0.0119 0.0119
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0033 0.006
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0033
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0046 0.0119 0.0213
Echinococcus multilocularis neuroligin 0.0293 0.0915 0.0915
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0011 0.0007 0.0007
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0046 0.0119 0.0119
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0025 0.0025
Brugia malayi Cytochrome P450 family protein 0.0011 0.0008 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0802
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0025 0.0025
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0032 0.0074 0.0585
Chlamydia trachomatis DNA gyrase subunit B 0.0047 0.0122 0.4585
Echinococcus multilocularis glutamate receptor 2 0.002 0.0035 0.0035
Echinococcus multilocularis lamin dm0 0.0011 0.0007 0.0007
Brugia malayi hypothetical protein 0.0026 0.0055 0.01
Brugia malayi Ubiquitin-like protein SMT3 0.0009 0.0001 0.0002
Brugia malayi ion channel NompC 0.0046 0.0119 0.0213
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0008 0.0008
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0293 0.0915 0.0915
Brugia malayi Niemann-Pick C1 protein precursor 0.0044 0.0114 0.0205
Leishmania major potassium voltage-gated channel, putative 0.005 0.0134 0.3487
Onchocerca volvulus 0.0046 0.0119 0.1273
Echinococcus multilocularis microtubule associated protein 2 0.0636 0.2017 0.2017
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0046 0.0119 0.0213
Toxoplasma gondii hypothetical protein 0.0046 0.0119 0.2752
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0029 0.0065 0.1501
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0006
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0111 0.0327 0.059
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0142 0.0428 0.0428
Leishmania major mitochondrial DNA topoisomerase II 0.0112 0.0331 0.8649
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0025 0.0045
Brugia malayi Probable DNA topoisomerase II 0.0142 0.0428 0.0771
Echinococcus granulosus transient receptor potential cation channel 0.0046 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0033 0.035
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0008 0.018
Brugia malayi hypothetical protein 0.0111 0.0327 0.059
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0088 0.0256 0.6687
Chlamydia trachomatis DNA gyrase subunit A 0.0026 0.0055 0.0867
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0025 0.0025
Echinococcus multilocularis Small ubiquitin modifier 2 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0114 0.0114
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0005 0.0044
Trypanosoma brucei calcium-activated potassium channel, putative 0.0111 0.0327 0.8564
Echinococcus multilocularis nmda type glutamate receptor 0.0046 0.0119 0.0119
Trypanosoma brucei btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Brugia malayi MH2 domain containing protein 0.0054 0.0144 0.0259
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.002 0.0038 0.0068
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0097 0.0097
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0119 0.0119
Toxoplasma gondii hypothetical protein 0.0014 0.0018 0.0397
Echinococcus granulosus transient receptor potential cation channel 0.0046 0.0119 0.0119
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0119 0.0119
Trypanosoma brucei btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Schistosoma mansoni twik family of potassium channels-related 0.0111 0.0327 0.0327
Brugia malayi K+ channel tetramerisation domain containing protein 0.005 0.0134 0.0241
Schistosoma mansoni 6-phosphofructokinase 0.0032 0.0074 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.002 0.0038 0.0038
Echinococcus multilocularis acetylcholinesterase 0.1737 0.5553 0.5553
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0025 0.0025
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0119 0.1286
Onchocerca volvulus 0.0016 0.0025 0.0248
Leishmania major hypothetical protein, conserved 0.005 0.0134 0.3487
Loa Loa (eye worm) carboxylesterase 0.0293 0.0915 0.0915
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0025 0.0025
Trypanosoma brucei potassium voltage-gated channel, putative 0.005 0.0134 0.3487
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0046 0.0119 0.0213
Loa Loa (eye worm) glutamate receptor 2 0.002 0.0035 0.0035
Entamoeba histolytica phosphofructokinase, putative 0.0032 0.0074 0.1716
Trypanosoma cruzi btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0096 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0031
Schistosoma mansoni calcium-activated potassium channel 0.0111 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.005 0.0134 0.0134
Brugia malayi voltage-dependent calcium channel 0.0046 0.0119 0.0213
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0055 0.1431
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0111 0.0327 0.059
Schistosoma mansoni 6-phosphofructokinase 0.0032 0.0074 0.0074
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0113 0.0335 0.0335
Schistosoma mansoni transcription factor btf3 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0104 0.0104
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0046 0.0119 0.0119
Leishmania major DNA topoisomerase III, putative 0.0014 0.0018 0.0448
Trypanosoma brucei DNA topoisomerase III, putative 0.0014 0.0018 0.0448
Echinococcus granulosus cpg binding protein 0.0032 0.0075 0.0075
Schistosoma mansoni twik family of potassium channels-related 0.0111 0.0327 0.0327
Trypanosoma brucei DNA topoisomerase IA, putative 0.0014 0.0018 0.0448
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0111 0.0327 0.059
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0046 0.0119 0.3083
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Echinococcus granulosus voltage gated potassium channel 0.0096 0.028 0.028
Leishmania major cytochrome p450-like protein 0.0011 0.0008 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0002 0.0002
Echinococcus multilocularis 6 phosphofructokinase 0.0032 0.0074 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.1155 0.3682 0.3682
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0014 0.0018 0.0018
Schistosoma mansoni intermediate filament proteins 0.0011 0.0007 0.0007
Onchocerca volvulus 0.0293 0.0915 1
Echinococcus granulosus hypothetical protein 0.0046 0.0119 0.0119
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0042 0.0106 0.2767
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Mycobacterium ulcerans transmembrane cation transporter 0.0111 0.0327 0.3523
Brugia malayi DNA topoisomerase III 0.0014 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0095 0.0278 0.0278
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.028 0.028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.002 0.0038 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0025 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0025 0.0045
Loa Loa (eye worm) hypothetical protein 0.1137 0.3626 0.3626
Plasmodium vivax SET domain protein, putative 0.0009 0.0002 0.0031
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.028 0.028
Schistosoma mansoni twik family of potassium channels-related 0.0111 0.0327 0.0327
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0046 0.0119 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0025 0.0045
Schistosoma mansoni ATP-binding cassette transporter 0.002 0.0035 0.0035
Brugia malayi beta-NAC-like protein 0.001 0.0005 0.0009
Chlamydia trachomatis DNA gyrase subunit A 0.0026 0.0055 0.0867
Loa Loa (eye worm) hypothetical protein 0.0222 0.0687 0.0687
Giardia lamblia DNA topoisomerase III 0.0014 0.0018 0.0419
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0022 0.0022
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0111 0.0327 0.059
Schistosoma mansoni cpg binding protein 0.0032 0.0075 0.0075
Echinococcus granulosus short transient receptor potential channel 6 0.0046 0.0119 0.0119
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0025 0.0025
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0096 0.028 0.028
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0011 0.0007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0055
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0011 0.0007 0.0155
Onchocerca volvulus 0.0293 0.0915 1
Onchocerca volvulus Huntingtin homolog 0.0049 0.0129 0.1392
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0047 0.0047
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0111 0.0327 0.059
Schistosoma mansoni glutamate receptor AMPA 0.002 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Trypanosoma cruzi transcription factor btf3, putative 0.001 0.0005 0.0106
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0096 0.028 0.0505
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0009 0.0001 0.0001
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Echinococcus multilocularis conserved hypothetical protein 0.0046 0.0119 0.0119
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0014 0.0018 0.0187
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0046 0.0119 0.0119
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.005 0.0134 0.0134
Schistosoma mansoni gliotactin 0.0293 0.0915 0.0915
Onchocerca volvulus 0.0293 0.0915 1
Echinococcus granulosus transcription factor btf3 0.001 0.0005 0.0005
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0003 0.0005
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0096 0.028 0.028
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0025 0.0025
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0111 0.0327 0.0327
Echinococcus granulosus Niemann Pick C1 protein 0.0044 0.0114 0.0114
Echinococcus multilocularis potassium voltage gated channel protein 0.0096 0.028 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0305
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0293 0.0915 0.0915
Brugia malayi K+ channel tetramerisation domain containing protein 0.005 0.0134 0.0241
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0119 0.0119
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0046 0.0119 0.0119
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0046 0.0119 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.002 0.0038 0.0038
Schistosoma mansoni glutamate receptor NMDA 0.0062 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0025 0.0248
Loa Loa (eye worm) hypothetical protein 0.0063 0.0174 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0009 0.0002 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0198 0.0609 0.0609
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0046 0.0119 0.0119
Loa Loa (eye worm) transcription factor SMAD2 0.0054 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0025 0.0025
Echinococcus granulosus potassium channel subfamily K 0.0111 0.0327 0.0327
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0111 0.0327 0.0327
Giardia lamblia DNA topoisomerase II 0.0136 0.0408 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0104 0.0188
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0293 0.0915 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Echinococcus granulosus muscleblind protein 0.0222 0.0687 0.0687
Echinococcus granulosus dna polymerase kappa 0.0023 0.0047 0.0047
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0111 0.0327 0.059
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Echinococcus granulosus para nitrobenzyl esterase 0.0293 0.0915 0.0915
Brugia malayi Carboxylesterase family protein 0.0293 0.0915 0.1648
Echinococcus multilocularis survival motor neuron protein 1 0.0094 0.0276 0.0276
Schistosoma mansoni transient receptor potential channel 4 0.0046 0.0119 0.0119
Mycobacterium ulcerans DNA gyrase subunit A 0.0026 0.0055 0.0523
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0008 0.0008
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0111 0.0327 0.3571
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.005 0.0134 0.0241
Giardia lamblia DNA repair protein RAD52 0.0102 0.0299 0.7318
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0022 0.0022
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0111 0.0327 0.3571
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0046 0.0119 0.0119
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0046 0.0119 0.0119
Loa Loa (eye worm) calcium channel 0.0046 0.0119 0.0119
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0032 0.0074 0.1923
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0046 0.0119 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0134 0.3487
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0096 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Leishmania major basic transcription factor 3a, putative 0.001 0.0005 0.0106
Echinococcus multilocularis potassium voltage gated channel protein 0.0096 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.001 0.0005 0.0094
Plasmodium falciparum DNA topoisomerase 3, putative 0.0014 0.0018 0.04
Entamoeba histolytica hypothetical protein 0.0039 0.0097 0.2243
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0005 0.0044
Toxoplasma gondii NAC domain-containing protein 0.001 0.0005 0.0094
Mycobacterium ulcerans hypothetical protein 0.0047 0.0122 0.1254
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0166 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0025 0.0025
Loa Loa (eye worm) DNA topoisomerase III 0.0014 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0025 0.0045
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0046 0.0119 0.0119
Echinococcus granulosus glutamate receptor NMDA 0.0038 0.0096 0.0096
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.005 0.0134 0.0134
Loa Loa (eye worm) histone methyltransferase 0.001 0.0003 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0054 0.0054
Loa Loa (eye worm) ICD-1 protein 0.001 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0046 0.0119 0.3083
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0111 0.0327 0.059
Plasmodium vivax basic transcription factor 3b, putative 0.001 0.0005 0.0094
Onchocerca volvulus 0.005 0.0134 0.1442
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0102 0.0299 0.6973
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0111 0.0327 0.3571
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0044 0.0114 0.2645
Brugia malayi K+ channel tetramerisation domain containing protein 0.005 0.0134 0.0241
Echinococcus granulosus two pore calcium channel protein 1 0.0046 0.0119 0.0119
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0096 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Entamoeba histolytica hypothetical protein 0.0039 0.0097 0.2243
Brugia malayi K+ channel tetramerisation domain containing protein 0.005 0.0134 0.0241
Schistosoma mansoni hypothetical protein 0.0039 0.0097 0.0097
Echinococcus multilocularis two pore calcium channel protein 2 0.0046 0.0119 0.0119
Schistosoma mansoni microtubule-associated protein tau 0.0636 0.2017 0.2017
Brugia malayi Cytochrome P450 family protein 0.0011 0.0008 0.0014
Schistosoma mansoni calcium-activated potassium channel 0.0111 0.0327 0.0327
Brugia malayi hypothetical protein 0.0017 0.0026 0.0047
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0111 0.0327 0.342
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Brugia malayi Glutamate receptor 2 precursor 0.002 0.0035 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0327 0.8564
Brugia malayi phosphofructokinase 0.0032 0.0074 0.0134
Echinococcus multilocularis voltage dependent calcium channel 0.0046 0.0119 0.0119
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0046 0.0119 0.0119
Echinococcus multilocularis Niemann Pick C1 protein 0.0063 0.0175 0.0175
Toxoplasma gondii ion channel protein 0.0111 0.0327 0.7644
Onchocerca volvulus 0.003 0.0069 0.0732
Loa Loa (eye worm) hypothetical protein 0.0853 0.2712 0.2712
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0011 0.0007 0.0007
Trypanosoma brucei unspecified product 0.0021 0.0041 0.1045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0025 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0025 0.0045
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0014 0.0018 0.0448
Plasmodium vivax DNA topoisomerase II, putative 0.0142 0.0428 1
Leishmania major ion transport protein-like protein 0.0111 0.0327 0.8564
Brugia malayi intermediate filament protein 0.0011 0.0007 0.0012
Echinococcus multilocularis transient receptor potential gamma protein 0.0046 0.0119 0.0119
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.005 0.0134 0.0134
Brugia malayi CHE-14 protein 0.0019 0.0033 0.0059
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0046 0.0119 0.0213
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0023 0.0047 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0047 0.1207
Schistosoma mansoni hypothetical protein 0.0111 0.0327 0.0327
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0026 0.0055 0.0373
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0012 0.0012 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.002 0.0038 0.0038
Plasmodium falciparum DNA topoisomerase 2 0.0142 0.0428 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0055 0.1431
Brugia malayi nuclear hormone receptor 0.0016 0.0025 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0025 0.0025
Leishmania major hypothetical protein, conserved 0.005 0.0134 0.3487
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0046 0.118
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0026 0.0055 0.3578
Loa Loa (eye worm) hypothetical protein 0.005 0.0134 0.0134
Echinococcus granulosus potassium large conductance calcium activated 0.0046 0.0119 0.0119
Echinococcus multilocularis short transient receptor potential channel 6 0.0046 0.0119 0.0119
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.028 0.028
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0046 0.0119 0.2752
Schistosoma mansoni twik family of potassium channels-related 0.0111 0.0327 0.0327
Onchocerca volvulus 0.0019 0.0034 0.0348
Echinococcus multilocularis glutamate receptor 2 0.0023 0.0047 0.0047
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0103 0.0303 0.3291
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0327 0.8564
Entamoeba histolytica phosphofructokinase, putative 0.0032 0.0074 0.1716
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0025 0.0025
Loa Loa (eye worm) uncoordinated protein 58 0.0111 0.0327 0.0327
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0096 0.028 0.0505
Schistosoma mansoni ryanodine receptor related 0.0046 0.0119 0.0119
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0128 0.0382 1
Loa Loa (eye worm) ryanodine receptor 0.0046 0.0119 0.0119
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0055 0.1431
Echinococcus granulosus GPCR family 2 0.0019 0.0033 0.0033
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0032 0.0074 0.1923
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0046 0.0119 0.0213
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Loa Loa (eye worm) phosphofructokinase 0.0032 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Plasmodium falciparum potassium channel 0.0111 0.0327 0.7644
Loa Loa (eye worm) hypothetical protein 0.0293 0.0915 0.0915
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0046 0.0119 0.0213
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0111 0.0327 0.059
Brugia malayi cation channel family protein 0.0046 0.0119 0.0213
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Echinococcus multilocularis musashi 0.0011 0.0007 0.0007
Trypanosoma brucei unspecified product 0.0011 0.0007 0.0146
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0157 0.3653
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0046 0.0119 0.0119
Trypanosoma cruzi transcription factor btf3, putative 0.001 0.0005 0.0106
Echinococcus multilocularis tumor protein p63 0.0164 0.0498 0.0498
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0047 0.0047
Echinococcus granulosus hyperpolarization activated cyclic 0.0046 0.0119 0.0119
Trypanosoma cruzi btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Echinococcus granulosus Protein patched homolog 1 0.0019 0.0033 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0293 0.0915 0.0915
Echinococcus multilocularis rho GTPase activating protein 20 0.0014 0.0018 0.0018
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0096 0.028 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.005 0.0134 0.0134
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0055 0.1277
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0111 0.0327 0.8564
Plasmodium vivax DNA gyrase subunit A, putative 0.0026 0.0055 0.1272
Trypanosoma cruzi DNA topoisomerase II, putative 0.0128 0.0382 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0012 0.0012 0.0291
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0012 0.0012 0.0291
Echinococcus multilocularis sodium channel protein 0.0076 0.0217 0.0217
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0022 0.0493
Trypanosoma cruzi DNA topoisomerase III, putative 0.0014 0.0018 0.0448
Schistosoma mansoni 60S ribosomal protein L21 0.0046 0.0119 0.0119
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0074 0.54
Echinococcus multilocularis short transient receptor potential channel 6 0.0046 0.0119 0.0119
Echinococcus multilocularis BTB:POZ domain containing protein 0.005 0.0134 0.0134
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0031
Toxoplasma gondii DNA topoisomerase 2, putative 0.0142 0.0428 1
Brugia malayi 6-phosphofructokinase 0.0032 0.0074 0.0134
Echinococcus granulosus dna polymerase eta 0.0023 0.0046 0.0046
Trypanosoma cruzi btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0111 0.0327 0.3571
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0025 0.0248
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.1155 0.3682 0.6631
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0111 0.0327 0.0327
Brugia malayi hypothetical protein 0.0049 0.0129 0.0233
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0046 0.0119 0.0119
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0293 0.0915 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0046 0.0119 0.0119
Echinococcus multilocularis potassium channel subfamily K 8 0.0111 0.0327 0.0327
Schistosoma mansoni vesicular amine transporter 0.0096 0.028 0.028
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0065
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0011 0.0007 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0309
Brugia malayi cation channel family protein 0.0046 0.0119 0.0213
Echinococcus granulosus twik family of potassium channels 0.0111 0.0327 0.0327
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0046 0.0119 0.0119
Mycobacterium ulcerans 6-phosphofructokinase 0.0032 0.0074 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0025 0.0025
Brugia malayi nuclear receptor NHR-88 0.0016 0.0025 0.0045
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0046 0.0119 0.0119
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0111 0.0327 0.8564
Leishmania major DNA polymerase eta, putative 0.0012 0.0012 0.0278
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0025 0.0025
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0046 0.0119 0.0213
Brugia malayi olfactory channel protein osm-9 0.0046 0.0119 0.0213
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0047 0.0122 1
Echinococcus multilocularis transient receptor potential cation channel 0.0046 0.0119 0.0119
Schistosoma mansoni coup transcription factor 0.0016 0.0025 0.0025
Schistosoma mansoni transient receptor potential channel 0.0046 0.0119 0.0119
Echinococcus granulosus potassium voltage gated channel protein 0.1155 0.3682 0.3682
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0046 0.0119 0.0119
Leishmania major hypothetical protein, conserved 0.0111 0.0327 0.8564
Giardia lamblia Hypothetical protein 0.0111 0.0327 0.8022
Mycobacterium ulcerans DNA topoisomerase I 0.0014 0.0018 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Plasmodium vivax kelch protein K13, putative 0.005 0.0134 0.3112
Echinococcus granulosus histone lysine methyltransferase setb 0.0009 0.0002 0.0002
Leishmania major ATP-dependent phosphofructokinase 0.0032 0.0074 0.1923
Loa Loa (eye worm) SMO-1 protein 0.0009 0.0001 0.0001
Echinococcus multilocularis transient receptor potential cation channel 0.0046 0.0119 0.0119
Schistosoma mansoni DNA polymerase eta 0.0023 0.0046 0.0046
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0023 0.0047 0.0047
Echinococcus granulosus transient receptor potential cation channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0142 0.0428 0.0428
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0111 0.0327 0.7644
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0111 0.0327 0.3571
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0119 0.0119
Echinococcus granulosus glutamate NMDA receptor subunit 0.0046 0.0121 0.0121
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0047 0.0432
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0025 0.0045
Echinococcus multilocularis cpg binding protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) 6-phosphofructokinase 0.0032 0.0074 0.0074
Brugia malayi Glutamate receptor 1 precursor 0.002 0.0035 0.0063
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Onchocerca volvulus 0.007 0.0197 0.2131
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0046 0.0119 0.0213
Echinococcus multilocularis sodium leak channel non selective protein 0.0046 0.0119 0.0119
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0025 0.0045
Schistosoma mansoni DNA topoisomerase II 0.0142 0.0428 0.0428
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0014 0.0018 0.0018
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0046 0.0119 0.0213
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0009 0.0002 0.0002
Trypanosoma cruzi btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Loa Loa (eye worm) acetylcholinesterase 1 0.1737 0.5553 0.5553
Trypanosoma brucei btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0002 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0046 0.0083
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0014 0.0018 0.0187
Brugia malayi CXXC zinc finger family protein 0.003 0.0069 0.0125
Onchocerca volvulus 0.0111 0.0327 0.3562
Leishmania major hypothetical protein, conserved 0.0111 0.0327 0.8564
Schistosoma mansoni acetylcholinesterase 0.0293 0.0915 0.0915
Echinococcus granulosus Niemann Pick C1 protein 0.0063 0.0175 0.0175
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0046 0.0119 0.0119
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0041 0.0104 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0047 0.1207
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0047 0.1207
Loa Loa (eye worm) hypothetical protein 0.0293 0.0915 0.0915
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0025 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.002 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0046 0.0119 0.1273
Schistosoma mansoni glutamate receptor kainate 0.002 0.0035 0.0035
Schistosoma mansoni twik family of potassium channels-related 0.0111 0.0327 0.0327
Schistosoma mansoni patched 1 0.0019 0.0033 0.0033
Trypanosoma cruzi DNA topoisomerase II, putative 0.0128 0.0382 1
Mycobacterium ulcerans ion transport protein 0.0111 0.0327 0.3523
Schistosoma mansoni cpg binding protein 0.003 0.0069 0.0069
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0134 0.0134
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0025 0.0025
Schistosoma mansoni two-pore calcium channel 0.0046 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0309
Onchocerca volvulus 0.0293 0.0915 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0293 0.0915 0.0915
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0047 0.0503
Onchocerca volvulus 0.0111 0.0327 0.3562
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0122 0.1115
Brugia malayi steroid hormone receptor 0.0016 0.0025 0.0045
Schistosoma mansoni cpg binding protein 0.0032 0.0075 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.002 0.0038 0.0038
Onchocerca volvulus 0.0011 0.0007 0.0049
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0111 0.0327 0.0327
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0015 0.0021 0.052
Loa Loa (eye worm) carboxylesterase 0.0293 0.0915 0.0915
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0111 0.0327 0.059
Echinococcus multilocularis small conductance calcium activated potassium 0.312 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0561 0.1775 0.1775
Loa Loa (eye worm) hypothetical protein 0.003 0.007 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0028 0.0715
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0088 0.0256 0.6687
Trypanosoma cruzi potassium voltage-gated channel 0.005 0.0134 0.3487
Plasmodium falciparum potassium channel 0.0111 0.0327 0.7644
Brugia malayi Carboxylesterase family protein 0.0293 0.0915 0.1648
Leishmania major mitochondrial DNA polymerase beta 0.0088 0.0256 0.6687
Trypanosoma brucei transcription factor BTF3, putative 0.001 0.0005 0.0106
Trichomonas vaginalis spcc417.12 protein, putative 0.0293 0.0915 1
Echinococcus granulosus potassium voltage gated channel protein 0.0096 0.028 0.028
Loa Loa (eye worm) TOPoisomerase family member 0.0142 0.0428 0.0428
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0013 0.0305
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0802
Echinococcus granulosus two pore calcium channel protein 2 0.0046 0.0119 0.0119
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.005 0.0134 0.0134
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0025 0.0025
Onchocerca volvulus 0.0111 0.0327 0.3562
Trypanosoma brucei btb/poz domain containing protein, putative 0.005 0.0134 0.3487
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0045 0.0116 0.0116
Toxoplasma gondii hypothetical protein 0.0046 0.0119 0.2752
Toxoplasma gondii transporter, cation channel family protein 0.0046 0.0119 0.2752
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0025 0.0025
Echinococcus granulosus short transient receptor potential channel 6 0.0046 0.0119 0.0119
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0046 0.0119 0.0119
Echinococcus granulosus transient receptor potential cation channel 0.0046 0.0119 0.0119
Entamoeba histolytica transcription factor BTF3, putative 0.001 0.0005 0.0094
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Trichomonas vaginalis DNA topoisomerase II, putative 0.0142 0.0428 0.4672
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Echinococcus granulosus voltage gated hydrogen channel 1 0.0046 0.0119 0.0119
Echinococcus granulosus transient receptor potential cation channel 0.0046 0.0119 0.0119
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.005 0.0134 0.3112
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0119 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0025 0.0045
Schistosoma mansoni glutamate receptor kainate 0.002 0.0035 0.0035
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0142 0.0428 0.0771
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327
Echinococcus granulosus transient receptor potential gamma protein 0.0046 0.0119 0.0119
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0011 0.0007 0.0155
Toxoplasma gondii transporter, cation channel family protein 0.0046 0.0119 0.2752
Leishmania major hypothetical protein, conserved 0.005 0.0134 0.3487
Echinococcus multilocularis ryanodine receptor 44f 0.0046 0.0119 0.0119
Echinococcus multilocularis carboxylesterase 5A 0.1737 0.5553 0.5553
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0293 0.0915 0.0915
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0028 0.0069
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0802
Echinococcus multilocularis hyperpolarization activated cyclic 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0033
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0111 0.0327 0.0327

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 560 nM Inhibtion of [125I]-Tyr-o-CRF binding to Corticotropin releasing factor receptor 1 expressed in IMR-32 human neuroblastoma cells ChEMBL. 15603967
Ki (binding) = 560 nM Inhibtion of [125I]-Tyr-o-CRF binding to Corticotropin releasing factor receptor 1 expressed in IMR-32 human neuroblastoma cells ChEMBL. 15603967

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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