Detailed information for compound 319824

Basic information

Technical information
  • TDR Targets ID: 319824
  • Name: methyl 3-[1-[4-fluoro-3-(trifluoromethyl)phen yl]propyl]-2-sulfanylidene-1H-imidazole-4-car boxylate
  • MW: 362.342 | Formula: C15H14F4N2O2S
  • H donors: 0 H acceptors: 2 LogP: 4.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(n1c(S)ncc1C(=O)OC)c1ccc(c(c1)C(F)(F)F)F
  • InChi: 1S/C15H14F4N2O2S/c1-3-11(21-12(13(22)23-2)7-20-14(21)24)8-4-5-10(16)9(6-8)15(17,18)19/h4-7,11H,3H2,1-2H3,(H,20,24)
  • InChiKey: ROMDDEQTMYTOPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 3-[1-[4-fluoro-3-(trifluoromethyl)phenyl]propyl]-2-thioxo-1H-imidazole-4-carboxylate
  • 3-[1-[4-fluoro-3-(trifluoromethyl)phenyl]propyl]-2-thioxo-1H-imidazole-4-carboxylic acid methyl ester
  • 3-[1-[4-fluoro-3-(trifluoromethyl)phenyl]propyl]-2-thioxo-4-imidazoline-4-carboxylic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0511 0.129
Schistosoma mansoni ferritin 0.0008 0.0002 0.0004
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0218 0.082
Loa Loa (eye worm) hypothetical protein 0.0081 0.0338 0.127
Onchocerca volvulus 0.0094 0.0403 0.3658
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0511 0.463
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0054 0.0202
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0511 0.4409
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0511 0.4771
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0029
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0025 0.0178
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0108 0.0273
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0061 0.0155
Schistosoma mansoni regulator of G protein signaling 0.002 0.0054 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Plasmodium vivax GMP synthetase, putative 0.0038 0.0138 0.0423
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.011 0.0335
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.0381 0.9478
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0055 0.014
Trypanosoma brucei NAD+ synthase, putative 0.0094 0.0402 0.3745
Onchocerca volvulus 0.0021 0.0061 0.0558
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0082 0.008
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0511 0.4789
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0131 0.1178
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0131 0.0331
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0082 0.0693
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0051 0.0147
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0025 0.0212
Entamoeba histolytica fatty acid elongase, putative 0.0088 0.0375 0.7212
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0054 0.0202
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.0381 0.12
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0003 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0082 0.0714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0108 0.0273
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0094 0.0402 0.3643
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.011 0.0941
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0108 0.0273
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0043 0.0161
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0404 0.3659
Echinococcus multilocularis cpg binding protein 0.0032 0.0113 0.0285
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0236 0.1063 1
Brugia malayi Cytochrome P450 family protein 0.0017 0.0043 0.0161
Echinococcus granulosus lamin 0.0084 0.0353 0.0892
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0108 0.0273
Echinococcus granulosus DNA directed RNA polymerase II subunit RPB2 0.0013 0.0023 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Brugia malayi hypothetical protein 0.002 0.0054 0.0202
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0236 0.1063 1
Mycobacterium ulcerans arylsulfatase AtsB 0.0009 0.0003 0.0001
Mycobacterium ulcerans NAD synthetase 0.0094 0.0402 0.0401
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0082 0.1193
Mycobacterium tuberculosis Possible hydrolase 0.0009 0.0003 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0055 0.0467
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0054 0.0136
Brugia malayi PHD-finger family protein 0.0009 0.0005 0.0019
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0009 0.0003 0.0014
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0009 0.0005 0.0013
Schistosoma mansoni bromodomain containing protein 0.0009 0.0005 0.0013
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0003 0.0007
Echinococcus granulosus dihydrofolate reductase 0.0197 0.0883 0.2231
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0038 0.0138 0.1247
Schistosoma mansoni axis inhibition protein axin 0.002 0.0054 0.0136
Loa Loa (eye worm) dihydrofolate reductase 0.0197 0.0883 0.3315
Brugia malayi follicle stimulating hormone receptor 0.0487 0.2237 0.8395
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0054 0.0136
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0237 0.0889
Brugia malayi 6-phosphofructokinase 0.0117 0.0511 0.1916
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0043 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0055 0.0498
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0082 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Leishmania major cytochrome p450-like protein 0.0017 0.0043 0.0349
Entamoeba histolytica hypothetical protein 0.002 0.0054 0.0623
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0724 0.2718
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.0306
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0511 0.4771
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0013 0.0023 0.0199
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0082 0.1193
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0236 0.1063 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0988
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0511 0.129
Echinococcus multilocularis musashi 0.0084 0.0353 0.0892
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0131 0.1211
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.0306
Brugia malayi PXA domain containing protein 0.002 0.0054 0.0202
Brugia malayi PXA domain containing protein 0.002 0.0054 0.0202
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0062 0.0254 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0108 0.2578
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.068 0.3141 0.314
Giardia lamblia NH3-dependent NAD+ synthetase 0.0094 0.0402 0.9957
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0353 0.1325
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0353 0.1325
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0094 0.0402 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0082 0.008
Schistosoma mansoni ferritin 0.0008 0.0002 0.0004
Plasmodium falciparum histone acetyltransferase GCN5 0.0082 0.0346 0.1086
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.0381 0.9478
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0057 0.0226 0.0571
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.0349 0.0882
Brugia malayi DNA-directed RNA polymerase, beta subunit family protein 0.0013 0.0023 0.0088
Schistosoma mansoni zinc finger protein 0.0009 0.0005 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0046 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0404 0.3659
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0988
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0236 0.1063 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.011 0.2627
Leishmania major DNA-directed RNA polymerase polypeptide, putative 0.0013 0.0023 0.0164
Schistosoma mansoni cpg binding protein 0.0032 0.0113 0.0285
Onchocerca volvulus 0.0084 0.0353 0.3206
Loa Loa (eye worm) RNA polymerase III 128kD subunit-PA 0.0013 0.0023 0.0088
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0038 0.0138 0.042
Schistosoma mansoni hypothetical protein 0.0855 0.3958 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0054 0.0136
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0404 0.102
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0131 0.1211
Brugia malayi Pre-SET motif family protein 0.0214 0.0963 0.3615
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.0349 0.0882
Echinococcus granulosus dnaJ subfamily B 0.0855 0.3958 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0724 0.2718
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0054 0.0136
Plasmodium vivax DNA-directed RNA polymerase I subunit RPA2, putative 0.0009 0.0006 0.0003
Echinococcus granulosus zinc finger protein 0.0009 0.0005 0.0013
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0236 0.1063 1
Treponema pallidum NAD synthetase 0.0094 0.0402 0.347
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0011 0.0043
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0055 0.016
Loa Loa (eye worm) hypothetical protein 0.0084 0.0353 0.1325
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0019
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0054 0.0136
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0054 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0404 0.3659
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0082 0.0306
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0082 0.0714
Toxoplasma gondii exonuclease III APE 0.002 0.0055 0.1246
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0511 0.1916
Schistosoma mansoni ap endonuclease 0.002 0.0055 0.014
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0151 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0003 0.0001
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0094 0.0402 0.1016
Mycobacterium ulcerans hypothetical protein 0.0026 0.0082 0.008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0487 0.2237 0.8395
Brugia malayi hypothetical protein 0.0021 0.0061 0.023
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0055 0.0656
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0054 0.0475
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0038 0.0138 0.1247
Onchocerca volvulus 0.0026 0.0082 0.0741
Brugia malayi hypothetical protein 0.0065 0.0266 0.0998
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0055 0.0467
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0151 0.0381
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0054 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0404 0.3659
Trypanosoma cruzi RNA polymerase I second largest subunit, putative 0.0009 0.0006 0.0033
Loa Loa (eye worm) hypothetical protein 0.0082 0.0346 0.1298
Schistosoma mansoni lipoxygenase 0.006 0.0241 0.0608
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0043 0.0381
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0404 0.7808
Entamoeba histolytica fatty acid elongase, putative 0.0088 0.0375 0.7212
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0054 0.0136
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0404 0.1516
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0404 0.3762
Brugia malayi Pre-SET motif family protein 0.0031 0.0108 0.0406
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0055 0.014
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.3143 0.7941
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0038 0.0138 0.0348
Trichomonas vaginalis DNA-directed RNA polymerase III subunit, putative 0.0013 0.0023 0.0199
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0025 0.0178
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.068 0.3141 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.0105 0.0393
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.0381 0.0964
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0511 0.1916
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0009 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0131 0.1178
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0094 0.0402 0.347
Schistosoma mansoni regulator of G protein signaling 0.002 0.0054 0.0136
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0094 0.0402 0.1266
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0061 0.0179
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0131 0.2208
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0054 0.0202
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0054 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0055 0.0207
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0305 0.1389 0.3509
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0075 0.0314 0.2937
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0055 0.049
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0131 0.0331
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0055 0.0207
Echinococcus granulosus geminin 0.017 0.0755 0.1907
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0131 0.1178
Brugia malayi bZIP transcription factor family protein 0.0083 0.0349 0.131
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0237 0.2184
Echinococcus multilocularis lamin 0.0084 0.0353 0.0892
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0236 0.1063 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.0093 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0237 0.0599
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB2 0.0013 0.0023 0.0059
Echinococcus granulosus histone acetyltransferase KAT2B 0.0297 0.1349 0.3407
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0043 0.0349
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0988
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.011 0.0332
Brugia malayi hypothetical protein 0.0021 0.0061 0.023
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0404 0.3782
Plasmodium falciparum DNA-directed RNA polymerase III subunit RPC2, putative 0.0013 0.0023 0.0055
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0055 0.049
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0055 0.014
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0724 0.183
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0236 0.1063 1
Schistosoma mansoni lipoxygenase 0.0021 0.0061 0.0155
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0236 0.1063 1
Brugia malayi dihydrofolate reductase family protein 0.0197 0.0883 0.3315
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.0381 0.3455
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0029
Trypanosoma brucei glucosidase, putative 0.0036 0.0131 0.1182
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0256 0.1156 0.3677
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0025 0.0093
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0082 0.008
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0131 0.3155
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0043 0.0161
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0171 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0009 0.0003 0.0028
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0003 0.0007
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0054 0.0202
Onchocerca volvulus 0.0031 0.0105 0.0951
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0131 0.0492
Schistosoma mansoni jun-related protein 0.0067 0.0276 0.0699
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0511 0.0509
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0009 0.0002 0.0003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0055 0.014
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.011 0.2672
Brugia malayi GMP synthase 0.0038 0.0138 0.0518
Brugia malayi NC domain containing protein 0.0042 0.0158 0.0591
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0051 0.0144
Brugia malayi intermediate filament protein 0.0084 0.0353 0.1325
Trypanosoma brucei DNA-directed RNA polymerase III, putative 0.0013 0.0023 0.0164
Schistosoma mansoni alpha glucosidase 0.0036 0.0131 0.0331
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0256 0.1156 1
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0511 0.463
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0197 0.0883 0.7637
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0061 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0082 0.008
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0131 0.1178
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0025 0.0212
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0055 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0082 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0046 0.0045
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0061 0.0155
Schistosoma mansoni ferritin light chain 0.0008 0.0002 0.0004
Schistosoma mansoni loxhd1 0.0021 0.0061 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0404 0.3659
Brugia malayi 6-phosphofructokinase 0.0117 0.0511 0.1916
Echinococcus granulosus cpg binding protein 0.0032 0.0113 0.0285
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0003 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0055 0.0208
Echinococcus multilocularis geminin 0.017 0.0755 0.1907
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0511 0.129
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0511 0.129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0193
Echinococcus multilocularis dnaJ subfamily B 0.0855 0.3958 1
Schistosoma mansoni alpha-glucosidase 0.014 0.0618 0.1561
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.011 0.0335
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0055 0.1307
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0353 0.1325
Giardia lamblia Kinase, PLK 0.0095 0.0404 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0082 0.0714
Entamoeba histolytica fatty acid elongase, putative 0.0088 0.0375 0.7212
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0193
Echinococcus multilocularis RUN 0.0021 0.0061 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Schistosoma mansoni cpg binding protein 0.0032 0.0113 0.0285
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0011 0.004
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0094 0.0402 0.0401
Trypanosoma brucei calpain-like protein, putative 0.0236 0.1063 1
Schistosoma mansoni axis inhibition protein axin 0.002 0.0054 0.0136
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0082 0.0693
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0963 0.3615
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0054 0.0475
Brugia malayi phosphofructokinase 0.0117 0.0511 0.1916
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0236 0.1063 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0131 0.1178
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0061 0.0176
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.011 0.0988
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1101 1
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0155
Brugia malayi small heat shock protein 0.0578 0.2664 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0236 0.1063 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.0241 0.0608
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0511 0.1916
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0237 0.0235
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0043 0.0041
Echinococcus granulosus intermediate filament protein 0.0084 0.0353 0.0892
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0511 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0009 0.0005 0.0013
Onchocerca volvulus 0.0244 0.1101 1
Schistosoma mansoni dihydrofolate reductase 0.0197 0.0883 0.2231
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0131 0.0492
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0193
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0054 0.0475
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0988
Brugia malayi Doublecortin family protein 0.0021 0.0061 0.023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0055 0.0498
Entamoeba histolytica fatty acid elongase, putative 0.0088 0.0375 0.7212
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.027 0.0683
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0518
Schistosoma mansoni regulator of G protein signaling 0.002 0.0054 0.0136
Onchocerca volvulus 0.0065 0.0266 0.2415
Mycobacterium tuberculosis Probable sulfatase 0.0009 0.0003 0.0001
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.0241 0.0608
Echinococcus multilocularis ferritin 0.0008 0.0002 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0131 0.1178
Brugia malayi hypothetical protein 0.0125 0.0546 0.2048
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0075 0.0314 0.0983
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0054 0.0202
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0075 0.0314 0.2913
Echinococcus multilocularis lamin dm0 0.0084 0.0353 0.0892
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0082 0.008
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0094 0.0402 0.1263
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0054 0.0202
Echinococcus granulosus axis inhibition protein axin 0.002 0.0054 0.0136
Mycobacterium ulcerans arylsulfatase, AslA 0.0009 0.0003 0.0001
Onchocerca volvulus UPF0528 protein homolog 0.0042 0.0158 0.1431
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0202
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0197 0.0883 0.0882
Echinococcus granulosus axis inhibition protein axin 0.002 0.0054 0.0136
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0404 0.3782
Schistosoma mansoni intermediate filament proteins 0.0084 0.0353 0.0892
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.011 0.019
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0054 0.0202
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0054 0.0136
Brugia malayi acetyltransferase, GNAT family protein 0.0305 0.1389 0.5212
Schistosoma mansoni ferritin 0.0008 0.0002 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.01 0.0252
Entamoeba histolytica NAD synthetase, putative 0.0094 0.0402 0.7773
Leishmania major NAD synthase, putative 0.0094 0.0402 0.3745
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0054 0.0136
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0054 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Schistosoma mansoni DNA-directed rna polymerase II subunit 0.0013 0.0023 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0055 0.014
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.011 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.2148 1 1
Schistosoma mansoni ferritin light chain 0.0008 0.0002 0.0004
Brugia malayi DNA-directed RNA polymerase II second largest subunit, putative 0.0013 0.0023 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0108 0.0273
Brugia malayi hypothetical protein 0.002 0.0054 0.0202
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0055 0.0467
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0043 0.0381
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0273 0.6733
Schistosoma mansoni GMP synthetase 0.0038 0.0138 0.0348
Trypanosoma brucei calpain, putative 0.0236 0.1063 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0054 0.0136
Schistosoma mansoni cpg binding protein 0.0031 0.0105 0.0265
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.023
Onchocerca volvulus 0.0084 0.0353 0.3206
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0131 0.1178
Mycobacterium ulcerans hydrolase 0.0009 0.0003 0.0001
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0038 0.0138 0.0348
Brugia malayi hypothetical protein 0.0009 0.0003 0.0011
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0025 0.021
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0131 0.2208
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0082 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0404 0.1516
Plasmodium vivax SET domain protein, putative 0.0031 0.0108 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0054 0.0475
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0082 0.1193
Trypanosoma cruzi NAD+ synthase, putative 0.0094 0.0402 0.3766
Brugia malayi Bromodomain containing protein 0.0009 0.0005 0.0019
Brugia malayi DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide 0.0013 0.0023 0.0088
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0093 0.0348
Mycobacterium ulcerans sulfatase 0.0009 0.0003 0.0001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0025 0.0029
Brugia malayi Cytochrome P450 family protein 0.0017 0.0043 0.0161
Loa Loa (eye worm) hypothetical protein 0.0039 0.0143 0.0539
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0075 0.0314 0.7779
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0055 0.0208
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0054 0.0136
Onchocerca volvulus 0.0011 0.0016 0.0141
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0236 0.1063 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0027
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0055 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Loa Loa (eye worm) DNA-directed RNA polymerase II second largest subunit 0.0013 0.0023 0.0088
Schistosoma mansoni hypothetical protein 0.017 0.0755 0.1907
Schistosoma mansoni apoferritin-2 0.0008 0.0002 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0054 0.0136
Trypanosoma brucei DNA-directed RNA polymerase II subunit 2, putative 0.0013 0.0023 0.0164
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.011 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0054 0.0475
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0054 0.0136
Mycobacterium ulcerans GMP synthase 0.0038 0.0138 0.0136
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0236 0.1063 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0193
Schistosoma mansoni hypothetical protein 0.0067 0.0276 0.0699
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0237 0.0235
Echinococcus granulosus jun protein 0.0083 0.0349 0.0882
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0082 0.0306
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0404 0.3668
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0069 0.0286 0.0894
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0093
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA2 0.0013 0.0023 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0025 0.0212
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0013 0.0023 0.0059
Loa Loa (eye worm) hypothetical protein 0.0578 0.2664 1
Toxoplasma gondii hypothetical protein 0.0042 0.0158 0.3825
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0591
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.011 0.2627
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0256 0.1156 0.1155
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0061 0.0155
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0724 0.183
Loa Loa (eye worm) acetyltransferase 0.0305 0.1389 0.5212
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0061 0.0155
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0131 0.1178
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.0381 0.3455
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0988
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0013 0.0023 0.0059
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0565
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0197 0.0883 0.0882
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0404 0.3659
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0025 0.021
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0009 0.0006 0.0076
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0054 0.0136
Echinococcus granulosus RUN 0.0021 0.0061 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0054 0.0475
Plasmodium vivax DNA-directed RNA polymerase II subunit RPB2, putative 0.0013 0.0023 0.0058
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0082 0.008
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0511 0.0509
Echinococcus granulosus expressed protein 0.0008 0.0002 0.0004
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.068 0.3141 0.314
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0181 0.1629
Loa Loa (eye worm) hypothetical protein 0.0039 0.0143 0.0539
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0054 0.0136
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0054 0.0136
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0082 0.008
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0025 0.0226
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0511 0.463
Echinococcus multilocularis dihydrofolate reductase 0.0197 0.0883 0.2231
Schistosoma mansoni alpha-glucosidase 0.014 0.0618 0.1561
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.068 0.3141 0.314
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0108 0.0273
Echinococcus multilocularis expressed protein 0.0383 0.1752 0.4426
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0075 0.0314 0.0985
Entamoeba histolytica hypothetical protein 0.002 0.0054 0.0623
Schistosoma mansoni hypothetical protein 0.017 0.0755 0.1907
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0236 0.1063 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0404 0.102
Schistosoma mansoni ferritin 0.0008 0.0002 0.0004
Schistosoma mansoni bromodomain containing protein 0.0009 0.0005 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0003 0.0007
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0038 0.0138 0.3328
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0131 0.1182
Schistosoma mansoni regulator of G protein signaling 0.002 0.0054 0.0136
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0061 0.0155
Plasmodium falciparum DNA-directed RNA polymerase II subunit RPB2, putative 0.0013 0.0023 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0181 0.1629
Giardia lamblia DNA-directed RNA polymerase RPB2 0.0013 0.0023 0.0509
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0108 0.0273
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0511 0.463
Toxoplasma gondii DNA-directed RNA polymerase III RPC2 0.0013 0.0023 0.0439
Schistosoma mansoni rab6-interacting 0.0021 0.0061 0.0155
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0075 0.0314 0.2913
Chlamydia trachomatis dihydrofolate reductase 0.0197 0.0883 0.2692
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0013 0.0023 0.0509
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0131 0.1178
Schistosoma mansoni polycystin 1-related 0.0021 0.0061 0.0155
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0236 0.1063 1
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0256 0.1156 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0988
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0025 0.0212
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0055 0.0172
Schistosoma mansoni ap endonuclease 0.002 0.0055 0.014
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0511 0.4409
Plasmodium vivax DNA-directed RNA polymerase III subunit, putative 0.0013 0.0023 0.0058
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0202
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0237 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0404 0.3659
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0009 0.0002 0.0003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0171 0.0643
Echinococcus granulosus lamin dm0 0.0084 0.0353 0.0892
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0046 0.0045
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.3143 0.7941
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0237 0.0599
Schistosoma mansoni kinase 0.0048 0.0186 0.0471
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.011 0.2627
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0025 0.0212
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.068 0.3141 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Schistosoma mansoni apoferritin-2 0.0008 0.0002 0.0004
Entamoeba histolytica hypothetical protein 0.002 0.0054 0.0623
Echinococcus granulosus expressed protein 0.0383 0.1752 0.4426
Giardia lamblia Histone acetyltransferase GCN5 0.0082 0.0346 0.8569
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0404 0.102
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0025 0.0212
Trypanosoma brucei hypothetical protein 0.0236 0.1063 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0025 0.0212
Schistosoma mansoni rab6-interacting 0.0021 0.0061 0.0155
Brugia malayi Dihydrofolate reductase 0.0197 0.0883 0.3315
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0054 0.0136
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0054 0.0475
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0511 1
Schistosoma mansoni lamin 0.0084 0.0353 0.0892
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0105 0.0393
Loa Loa (eye worm) DNA-directed RNA polymerase 0.0011 0.0012 0.0047
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0305 0.1389 0.3509
Onchocerca volvulus 0.0031 0.0108 0.0982
Schistosoma mansoni DNA-directed RNA polymerase I subunit 0.0009 0.0006 0.0015
Schistosoma mansoni lamin 0.0084 0.0353 0.0892
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0256 0.1156 0.3575
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0202
Echinococcus granulosus microtubule associated protein 2 0.0681 0.3143 0.7941
Trypanosoma cruzi DNA-directed RNA polymerase III, putative 0.0013 0.0023 0.0197
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0511 1
Loa Loa (eye worm) hypothetical protein 0.0326 0.1483 0.5567
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0007
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.068 0.3141 1
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC2 0.0013 0.0023 0.0059
Toxoplasma gondii DNA-directed RNA polymerase II RPB2 0.0013 0.0023 0.0439
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.023
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0202
Onchocerca volvulus 0.0021 0.0061 0.0558
Echinococcus multilocularis zinc finger protein 0.0009 0.0005 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0013 0.0023 0.0199
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA2 0.0013 0.0023 0.0059
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0236 0.1063 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0237 0.0599
Trypanosoma cruzi NAD+ synthase, putative 0.0094 0.0402 0.3766
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0055 0.014
Chlamydia trachomatis oxoacyl-ACP synthase III 0.068 0.3141 1
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC2 0.0013 0.0023 0.0059
Echinococcus multilocularis jun protein 0.0083 0.0349 0.0882
Trypanosoma brucei polo-like protein kinase 0.0095 0.0404 0.3762
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.011 0.1779
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.068 0.3141 0.314
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0046 0.0045
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0025 0.0212
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0061 0.023
Entamoeba histolytica fatty acid elongase, putative 0.0088 0.0375 0.7212
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0051 0.005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0055 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Loa Loa (eye worm) RGS-3 protein 0.002 0.0054 0.0202
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0055 0.014
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0202
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0011
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0003 0.0001
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0724 0.183
Echinococcus granulosus ferritin 0.0008 0.0002 0.0004
Brugia malayi Sulfatase family protein 0.0009 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.0306
Entamoeba histolytica acetyltransferase, GNAT family 0.0082 0.0346 0.6631
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0108 0.0406
Echinococcus multilocularis expressed protein 0.0008 0.0002 0.0004

Activities

Activity type Activity value Assay description Source Reference
Log IC50 (functional) = 6 Inhibitory activity against MCP-1 induced Calcium flux in THP11-cells ChEMBL. 15729771

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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