Detailed information for compound 320597

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 294.387 | Formula: C20H22O2
  • H donors: 0 H acceptors: 0 LogP: 5.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1c1cc(CC=C)ccc1OC)CC=C
  • InChi: 1S/C20H22O2/c1-5-7-15-9-11-19(21-3)17(13-15)18-14-16(8-6-2)10-12-20(18)22-4/h5-6,9-14H,1-2,7-8H2,3-4H3
  • InChiKey: GJMNJXRWNDXTIM-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0072 0.0072
Toxoplasma gondii thioredoxin reductase 0.0092 0.025 0.0395
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0072 0.0306
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0059 0.0079
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1784 0.6065 0.6063
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0059 0.0079
Leishmania major polyprenyl synthase, putative 0.045 0.148 0.2427
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Mycobacterium ulcerans hypothetical protein 0.003 0.0035 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0042 0.0052
Leishmania major hexokinase, putative 0.0183 0.0561 0.0909
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1784 0.6065 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0144 0.0427 0.2711
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.045 0.148 0.4838
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.045 0.148 0.2427
Trypanosoma brucei hexokinase 0.0183 0.0561 0.0909
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0173 0.0528 0.0854
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0075 0.0075
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0042 0.0052
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0072 0.0072
Brugia malayi beta-lactamase 0.0037 0.0059 0.0087
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0144 0.0427 0.2711
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0072 0.0066
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0044 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0149
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1784 0.6065 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Trypanosoma cruzi polyprenyl synthase, putative 0.045 0.148 0.2427
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.045 0.148 0.2427
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0084 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.1728 0.5873 0.587
Leishmania major solanesyl-diphosphate synthase, putative 0.045 0.148 0.2427
Schistosoma mansoni trans-prenyltransferase 0.045 0.148 0.148
Schistosoma mansoni hypothetical protein 0.0531 0.1757 0.1757
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.021 0.0656 0.2143
Schistosoma mansoni smad1 5 8 and 0.0041 0.0075 0.0075
Echinococcus granulosus glutamine synthetase 0.0118 0.034 0.0334
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0072 0.0108
Brugia malayi RNA binding protein 0.0066 0.0159 0.0253
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.021 0.0656 0.1066
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0084 0.0338
Plasmodium falciparum hexokinase 0.0183 0.0561 0.0909
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.045 0.148 1
Echinococcus granulosus cpg binding protein 0.0128 0.0373 0.0368
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Trypanosoma cruzi phytoene synthase, putative 0.0173 0.0528 0.0854
Onchocerca volvulus Huntingtin homolog 0.012 0.0347 0.2065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Brugia malayi CXXC zinc finger family protein 0.0121 0.035 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0084 0.0121
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.025 0.0244
Loa Loa (eye worm) glutathione reductase 0.0092 0.025 0.0402
Echinococcus granulosus intermediate filament protein 0.0027 0.0024 0.0018
Brugia malayi MH2 domain containing protein 0.0041 0.0075 0.0114
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.021 0.0656 0.1066
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0075 0.0069
Echinococcus granulosus hexokinase 0.0183 0.0561 0.0555
Schistosoma mansoni hypothetical protein 0.0144 0.0427 0.0427
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.045 0.148 0.1475
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0149 0.0143
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0234 0.0737 0.1199
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1784 0.6065 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.0326 0.032
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0042 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0044 0.0038
Echinococcus granulosus lamin dm0 0.0027 0.0024 0.0018
Schistosoma mansoni survival motor neuron protein 0.0047 0.0096 0.0096
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0098 0.0098
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.045 0.148 0.2427
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0024 0.0029
Echinococcus multilocularis hexokinase 0.0183 0.0561 0.0555
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0042 0.0052
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0072 0.0066
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.045 0.148 0.2433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0072 0.0108
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0159 0.0153
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Mycobacterium leprae Probable lipase LipE 0.0037 0.0059 0.0159
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0006 0.0006
Brugia malayi Hexokinase family protein 0.0183 0.0561 0.0916
Brugia malayi Thioredoxin reductase 0.0092 0.025 0.0402
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0042 0.0052
Schistosoma mansoni hypothetical protein 0.0115 0.0326 0.0326
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.004 0.0069 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0496 0.0496
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.0326 0.0529
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0042 0.0052
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0059 0.0079
Brugia malayi Pre-SET motif family protein 0.0423 0.1388 0.2281
Echinococcus granulosus hexokinase type 2 0.0183 0.0561 0.0555
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0059 0.0079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0261 0.0261
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1784 0.6065 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0042 0.0052
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1784 0.6065 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0059 0.0079
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0059 0.0053
Brugia malayi MH2 domain containing protein 0.0609 0.2024 0.3331
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0044 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0059 0.0079
Trypanosoma cruzi polyprenyl synthase, putative 0.045 0.148 0.2427
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0072 0.0108
Mycobacterium tuberculosis Probable dehydrogenase 0.021 0.0656 0.1066
Brugia malayi MH2 domain containing protein 0.0041 0.0075 0.0114
Loa Loa (eye worm) hypothetical protein 0.0247 0.0783 0.1283
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0084 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0072 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0072 0.0108
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.045 0.148 0.1475
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0044 0.0055
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 0.4972
Schistosoma mansoni cpg binding protein 0.0128 0.0373 0.0373
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.045 0.148 0.488
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0059 0.0079
Onchocerca volvulus 0.0048 0.0098 0.0473
Echinococcus granulosus dnaJ subfamily B 0.1728 0.5873 0.587
Brugia malayi follicle stimulating hormone receptor 0.0232 0.073 0.1194
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0072 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0072 0.0108
Trichomonas vaginalis esterase, putative 0.0037 0.0059 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0075 0.0069
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.003 0.0035 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0026
Trichomonas vaginalis helicase, putative 0.0027 0.0027 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Onchocerca volvulus Hexokinase homolog 0.0115 0.0327 0.1938
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Trichomonas vaginalis glutamine synthetase, putative 0.003 0.0035 0.004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0261 0.042
Onchocerca volvulus 0.0047 0.0096 0.046
Schistosoma mansoni coup transcription factor 0.004 0.0072 0.0072
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0072 0.0306
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0072 0.0108
Loa Loa (eye worm) hypothetical protein 0.0058 0.0132 0.0208
Loa Loa (eye worm) hypothetical protein 0.0048 0.0098 0.0151
Echinococcus granulosus FTZ F1 alpha 0.004 0.0072 0.0066
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.1388 0.2281
Toxoplasma gondii histone lysine methyltransferase SET1 0.0232 0.073 0.1188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0362 0.1177 0.1933
Plasmodium vivax hexokinase, putative 0.0183 0.0561 0.0909
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0042 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0261 0.0261
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0032 0.0044 0.0038
Leishmania major hypothetical protein, conserved 0.0037 0.0059 0.0079
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0899 0.3021 1
Loa Loa (eye worm) nuclear factor I 0.0023 0.0011 0.0009
Echinococcus granulosus geminin 0.0531 0.1757 0.1752
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0075 0.0069
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Schistosoma mansoni glutamine synthetase bacteria 0.003 0.0035 0.0035
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.045 0.148 0.1475
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0072 0.0072
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0159 0.0253
Brugia malayi hexokinase type II 0.0058 0.0132 0.0208
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.045 0.148 0.2427
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0042 0.0052
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0059 0.0079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0072 0.0108
Onchocerca volvulus 0.0481 0.1588 1
Schistosoma mansoni microtubule-associated protein tau 0.2929 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0059 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0059 0.0079
Schistosoma mansoni intermediate filament proteins 0.0027 0.0024 0.0024
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0084 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0261 0.0255
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.0357 0.0351
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0072 0.0108
Leishmania major trypanothione reductase 0.0092 0.025 0.0395
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1784 0.6065 0.6065
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1784 0.6065 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.0732 0.1198
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0149 0.0228
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0044 0.0055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Giardia lamblia Farnesyl diphosphate synthase 0.1784 0.6065 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0044 0.0044
Echinococcus granulosus neuropeptide s receptor 0.0519 0.1716 0.1711
Brugia malayi TAR-binding protein 0.0066 0.0159 0.0253
Entamoeba histolytica hexokinase 1 0.0183 0.0561 0.3638
Brugia malayi MH1 domain containing protein 0.0023 0.0011 0.0009
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0234 0.0737 0.2411
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0084 0.0078
Schistosoma mansoni smad1 5 8 and 0.0041 0.0075 0.0075
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0072 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0072 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0072 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.0427 0.0427
Onchocerca volvulus Glutamine synthetase homolog 0.0076 0.0194 0.1091
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0216 0.0675 0.1098
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.0357 0.0351
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0024 0.0029
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.045 0.148 0.2427
Schistosoma mansoni hypothetical protein 0.0531 0.1757 0.1757
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.045 0.148 0.2433
Echinococcus multilocularis GPCR, family 2 0.0115 0.0326 0.032
Toxoplasma gondii glutamine synthetase, type I, putative 0.0076 0.0194 0.0303
Echinococcus granulosus Squalene phytoene synthase 0.0173 0.0528 0.0522
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0084 0.0078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0362 0.1177 0.1933
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.045 0.148 0.4826
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1784 0.6065 1
Brugia malayi Polyprenyl synthetase family protein 0.1784 0.6065 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0042 0.0024
Entamoeba histolytica hypothetical protein 0.0144 0.0427 0.2711
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.045 0.148 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0326 0.0529
Plasmodium falciparum glutathione reductase 0.0092 0.025 0.0395
Trypanosoma cruzi squalene synthase, putative 0.0556 0.1843 0.3027
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0084 0.0084
Onchocerca volvulus 0.0121 0.035 0.2084
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0042 0.0024
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0084 0.0078
Echinococcus granulosus hexokinase 0.0183 0.0561 0.0555
Echinococcus multilocularis pyrroline 5 carboxylate reductase 0.0023 0.0011 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0072 0.0108
Trypanosoma cruzi squalene synthase, putative 0.0556 0.1843 0.3027
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0732 0.0726
Onchocerca volvulus 0.004 0.0072 0.0306
Trypanosoma brucei hexokinase 0.0183 0.0561 0.0909
Echinococcus granulosus mixed lineage leukemia protein mll 0.0032 0.0044 0.0038
Trypanosoma cruzi solanesyl-diphosphate synthase 0.045 0.148 0.2427
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0059 0.0079
Brugia malayi hypothetical protein 0.012 0.0347 0.0562
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0072 0.0108
Echinococcus multilocularis microtubule associated protein 2 0.2929 1 1
Brugia malayi pyrroline-5-carboxylate reductase family protein 0.0023 0.0011 0.0008
Schistosoma mansoni lamin 0.0027 0.0024 0.0024
Echinococcus multilocularis neuropeptide s receptor 0.0519 0.1716 0.1711
Loa Loa (eye worm) histone methyltransferase 0.004 0.0069 0.0104
Schistosoma mansoni hypothetical protein 0.1728 0.5873 0.5873
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.073 0.1194
Loa Loa (eye worm) hexokinase 0.0057 0.0127 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0075 0.0114
Onchocerca volvulus 0.0183 0.0561 0.3435
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0072 0.0066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.025 0.0244
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0072 0.0072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0261 0.042
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0013 0.0012
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0044 0.0055
Loa Loa (eye worm) hexokinase 0.0183 0.0561 0.0916
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0052
Trypanosoma cruzi glutamine synthetase, putative 0.0118 0.034 0.0543
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0149 0.0143
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.025 0.0395
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0149
Schistosoma mansoni lamin 0.0027 0.0024 0.0024
Loa Loa (eye worm) polyprenyl synthetase 0.1784 0.6065 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0261 0.0255
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0042 0.0052
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0899 0.3021 0.4972
Loa Loa (eye worm) Smad1 0.0041 0.0075 0.0114
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0496 0.0496
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.0427 0.0421
Mycobacterium ulcerans hypothetical protein 0.0037 0.0059 0.0079
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0072 0.0108
Schistosoma mansoni hypothetical protein 0.0123 0.0357 0.0357
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0013 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0072 0.0108
Mycobacterium tuberculosis Probable reductase 0.021 0.0656 0.1066
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0059 0.0159
Brugia malayi Pre-SET motif family protein 0.0063 0.0149 0.0236
Trypanosoma cruzi glutamine synthetase, putative 0.0118 0.034 0.0543
Loa Loa (eye worm) Gln-2 protein 0.0076 0.0194 0.0311
Brugia malayi Smad1 0.0041 0.0075 0.0114
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0059 0.0079
Brugia malayi Latrophilin receptor protein 2 0.0115 0.0326 0.0529
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0084 0.0121
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0072 0.0072
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0072 0.0066
Schistosoma mansoni smad 0.0041 0.0075 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0072 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0072 0.0108
Brugia malayi latrophilin 2 splice variant baaae 0.0247 0.0783 0.1283
Mycobacterium ulcerans beta-lactamase 0.0037 0.0059 0.0079
Brugia malayi beta-lactamase family protein 0.0037 0.0059 0.0087
Treponema pallidum hexokinase (hxk) 0.0183 0.0561 0.1827
Mycobacterium tuberculosis Conserved protein 0.0037 0.0059 0.0079
Brugia malayi nuclear receptor NHR-88 0.004 0.0072 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.026 0.0825 0.0825
Leishmania major glutamine synthetase, putative 0.0118 0.034 0.0543
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0899 0.3021 0.4972
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.0427 0.0421
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0084 0.0078
Leishmania major hypothetical protein, conserved 0.0173 0.0528 0.0854
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Echinococcus multilocularis lamin 0.0027 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.0063 0.0149 0.0236
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0044 0.0038
Trypanosoma brucei hexokinase, putative 0.0183 0.0561 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0072 0.0108
Loa Loa (eye worm) MH2 domain-containing protein 0.0609 0.2024 0.3331
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.045 0.148 1
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.045 0.148 0.2427
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.0739 0.1203
Leishmania major squalene synthase, putative 0.0556 0.1843 0.3027
Mycobacterium tuberculosis Putative ferredoxin reductase 0.021 0.0656 0.1066
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.025 0.0402
Loa Loa (eye worm) hexokinase 0.0183 0.0561 0.0916
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0084 0.0084
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.045 0.148 0.2427
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0044 0.0055
Loa Loa (eye worm) hypothetical protein 0.0044 0.0084 0.0129
Brugia malayi glutathione reductase 0.0092 0.025 0.0402
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0084 0.0121
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0072 0.0066
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0072 0.0066
Schistosoma mansoni Smad4 0.0041 0.0075 0.0075
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0044 0.0055
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.045 0.148 0.2427
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0076 0.0194 0.061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0044 0.0038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0084 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0072 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Mycobacterium tuberculosis Conserved protein 0.0037 0.0059 0.0079
Onchocerca volvulus 0.0037 0.0059 0.0225
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0059 0.0079
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0076 0.0194 0.0303
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0072 0.0108
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0044 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0072 0.0066
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0059 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.0326 0.032
Brugia malayi MH1 domain containing protein 0.0041 0.0075 0.0114
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.0496 0.049
Plasmodium falciparum glutamine synthetase, putative 0.0076 0.0194 0.0303
Plasmodium falciparum glutathione reductase 0.0032 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.012 0.0347 0.0562
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.045 0.148 0.148
Brugia malayi isocitrate dehydrogenase 0.0032 0.0044 0.0063
Mycobacterium ulcerans phytoene synthase, CrtB 0.0173 0.0528 0.0854
Echinococcus granulosus tar DNA binding protein 0.0066 0.0159 0.0153
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 0.4972
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0149 0.0143
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0076 0.0194 0.0303
Onchocerca volvulus 0.0183 0.0561 0.3435
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0006 0.0006
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0059 0.0053
Brugia malayi Polyprenyl synthetase family protein 0.045 0.148 0.2433
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0173 0.0528 0.3225
Plasmodium vivax SET domain protein, putative 0.0063 0.0149 0.0228
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.045 0.148 0.1475
Echinococcus multilocularis Smad4 0.0041 0.0075 0.0069
Echinococcus multilocularis neuropeptide receptor A26 0.0519 0.1716 0.1711
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0042 0.0052
Echinococcus multilocularis hexokinase type 2 0.0183 0.0561 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0072 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.045 0.148 0.2427
Loa Loa (eye worm) hexokinase 0.0115 0.0327 0.0529
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0149
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0059 0.0079
Echinococcus multilocularis hexokinase 0.0183 0.0561 0.0555
Loa Loa (eye worm) beta-lactamase 0.0037 0.0059 0.0087
Toxoplasma gondii hexokinase 0.0183 0.0561 0.0909
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1784 0.6065 1
Brugia malayi beta-lactamase family protein 0.0037 0.0059 0.0087
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0027 0.0027
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0044 0.0055
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0059 0.0079
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0084 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0261 0.0255
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0072 0.0066
Brugia malayi steroid hormone receptor 0.004 0.0072 0.0108
Brugia malayi MH1 domain containing protein 0.0023 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0058 0.0132 0.0208
Schistosoma mansoni hypothetical protein 0.0173 0.0528 0.0528
Toxoplasma gondii ABC1 family protein 0.0037 0.0059 0.0079
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1784 0.6065 0.6063
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.0326 0.0529
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0044 0.0038
Echinococcus multilocularis hexokinase 0.0183 0.0561 0.0555
Schistosoma mansoni glutamine synthetase bacteria 0.003 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0115 0.0326 0.0326
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0732 0.0726
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0072 0.0066
Echinococcus multilocularis smad 0.0041 0.0075 0.0069
Schistosoma mansoni cpg binding protein 0.0121 0.035 0.035
Loa Loa (eye worm) hypothetical protein 0.0173 0.0528 0.0862
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0072 0.0066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0159 0.0253
Brugia malayi glutamine synthetase 0.0042 0.0078 0.0118
Brugia malayi intermediate filament protein 0.0027 0.0024 0.0029
Brugia malayi nuclear hormone receptor 0.004 0.0072 0.0108
Trypanosoma brucei squalene synthase, putative 0.0556 0.1843 0.3027
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0059 0.0079
Echinococcus multilocularis tumor protein p63 0.0328 0.1061 0.1056
Echinococcus multilocularis lamin dm0 0.0027 0.0024 0.0018
Treponema pallidum NADH oxidase 0.0032 0.0042 0.0105
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0042 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Echinococcus granulosus pyrroline 5 carboxylate reductase 0.0023 0.0011 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0261 0.0255
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0072 0.0108
Brugia malayi MH1 domain containing protein 0.0041 0.0075 0.0114
Onchocerca volvulus 0.0037 0.0059 0.0225
Loa Loa (eye worm) hypothetical protein 0.0362 0.1177 0.1933
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0149 0.0149
Loa Loa (eye worm) transcription factor SMAD2 0.0609 0.2024 0.3331
Brugia malayi Hexokinase family protein 0.0057 0.0127 0.02
Trichomonas vaginalis set domain proteins, putative 0.0481 0.1588 0.2604
Trypanosoma brucei trypanothione reductase 0.0092 0.025 0.0395
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0084 0.0121
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0132 0.0126
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1784 0.6065 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.0326 0.032
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.2685 0.2681
Loa Loa (eye worm) polyprenyl synthetase 0.045 0.148 0.2433
Trypanosoma cruzi hexokinase, putative 0.0183 0.0561 0.0909
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0042 0.0052
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0044 0.0063
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.045 0.148 0.1475
Leishmania major farnesyl pyrophosphate synthase 0.1784 0.6065 1
Echinococcus granulosus smad 0.0041 0.0075 0.0069
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0059 0.0079
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0042 0.0052
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.0311 0.1001 0.1642
Schistosoma mansoni hypothetical protein 0.0115 0.0326 0.0326
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0042 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0059 0.0087
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0044 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0072 0.0108
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0084 0.0121
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0052
Treponema pallidum octaprenyl-diphosphate synthase 0.045 0.148 0.488
Brugia malayi hypothetical protein 0.0119 0.0343 0.0555
Onchocerca volvulus 0.0115 0.0327 0.1938
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1784 0.6065 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Schistosoma mansoni smad1 5 8 and 0.0041 0.0075 0.0075
Brugia malayi Calcitonin receptor-like protein seb-1 0.0362 0.1177 0.1933
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.025 0.0395
Echinococcus multilocularis musashi 0.0027 0.0024 0.0018
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0024 0.0029
Onchocerca volvulus 0.0037 0.0059 0.0225
Echinococcus granulosus lamin 0.0027 0.0024 0.0018
Schistosoma mansoni hypothetical protein 0.0047 0.0096 0.0096
Schistosoma mansoni cpg binding protein 0.0128 0.0373 0.0373
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.021 0.0656 0.1066
Schistosoma mansoni nuclear hormone receptor 0.004 0.0072 0.0072
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.045 0.148 0.2427
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.045 0.148 0.4838
Trypanosoma brucei glutamine synthetase, putative 0.0118 0.034 0.0543
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0075 0.0114
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0044 0.0055
Leishmania major hexokinase, putative 0.0183 0.0561 0.0909
Mycobacterium tuberculosis Probable oxidoreductase 0.0234 0.0737 0.1199
Echinococcus granulosus hexokinase 0.0183 0.0561 0.0555
Mycobacterium tuberculosis Conserved protein 0.0037 0.0059 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Brugia malayi hypothetical protein 0.0144 0.0427 0.0695
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.045 0.148 0.1475
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0042 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Echinococcus multilocularis cpg binding protein 0.0128 0.0373 0.0368
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.003 0.0035 0.004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0059 0.0079
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0042
Plasmodium falciparum thioredoxin reductase 0.0092 0.025 0.0395
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0036
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Plasmodium vivax glutamine synthetase, putative 0.0076 0.0194 0.0303
Brugia malayi hexokinase 0.0183 0.0561 0.0916
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0042 0.0052
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.045 0.148 0.2427
Entamoeba histolytica hypothetical protein 0.0144 0.0427 0.2711
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1784 0.6065 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Plasmodium falciparum thioredoxin reductase 0.0032 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.012 0.0347 0.0562
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0059 0.0059
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.025 0.0395
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.004 0.0069 0.0063
Brugia malayi Hexokinase family protein 0.0115 0.0327 0.0529
Mycobacterium ulcerans glutamine synthetase 0.0076 0.0194 0.0303
Echinococcus granulosus tumor protein p63 0.0328 0.1061 0.1056
Loa Loa (eye worm) hypothetical protein 0.0125 0.0361 0.0586
Schistosoma mansoni hypothetical protein 0.0247 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0036
Echinococcus granulosus GPCR family 2 0.0115 0.0326 0.032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0029
Brugia malayi ecdysteroid receptor 0.004 0.0072 0.0108
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0072 0.0306
Echinococcus granulosus Smad4 0.0041 0.0075 0.0069
Loa Loa (eye worm) CXXC zinc finger family protein 0.0121 0.035 0.0567
Onchocerca volvulus Huntingtin homolog 0.012 0.0347 0.2065
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0059 0.0079
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0044 0.0038
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0042 0.0052
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1784 0.6065 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0072 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0072 0.0108
Entamoeba histolytica hexokinase 2 0.0183 0.0561 0.3638
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Echinococcus multilocularis glutamine synthetase 0.0118 0.034 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0072 0.0108
Schistosoma mansoni hexokinase 0.0183 0.0561 0.0561
Echinococcus granulosus neuropeptide receptor A26 0.0519 0.1716 0.1711
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0261 0.0261
Echinococcus multilocularis Squalene phytoene synthase 0.0173 0.0528 0.0522
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.0326 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0009
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0068 0.0102
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0234 0.0737 0.1199
Loa Loa (eye worm) hexokinase type II 0.0183 0.0561 0.0916
Loa Loa (eye worm) RNA binding protein 0.0066 0.0159 0.0253
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0044 0.0063
Schistosoma mansoni hypothetical protein 0.0115 0.0326 0.0326
Plasmodium vivax glutathione reductase, putative 0.0092 0.025 0.0395
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0159 0.0253
Trypanosoma cruzi hexokinase, putative 0.0183 0.0561 0.0909
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0044 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0072 0.0108
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0042 0.0052
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0044 0.0055
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0096 0.0148
Brugia malayi hypothetical protein 0.0233 0.0732 0.1198
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0075 0.0069
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0118 0.034 0.034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0059 0.0059
Onchocerca volvulus 0.0063 0.0149 0.0802
Echinococcus multilocularis geminin 0.0531 0.1757 0.1752
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Schistosoma mansoni glutathione synthetase 0.045 0.148 0.148
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0072 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0044 0.0044
Onchocerca volvulus 0.0183 0.0561 0.3435
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0084 0.0129

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 200 uM Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined ChEMBL. 15582432
IC50 (functional) > 200 uM Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined ChEMBL. 15582432

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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