Detailed information for compound 322696

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 843.967 | Formula: C50H49N7O6
  • H donors: 11 H acceptors: 4 LogP: 4.02 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: OCC1OC(Oc2ccc(cc2)C2c3ccc([nH]3)C(c3ccc(cc3)N)c3ccc([nH]3)C(c3[nH]c(C(c4[nH]c2cc4)c2ccc(cc2)N)cc3)c2ccc(cc2)N)C(C(C1O)O)O
  • InChi: 1S/C50H49N7O6/c51-30-9-1-26(2-10-30)43-34-17-19-36(54-34)44(27-3-11-31(52)12-4-27)38-21-23-40(56-38)46(29-7-15-33(16-8-29)62-50-49(61)48(60)47(59)42(25-58)63-50)41-24-22-39(57-41)45(37-20-18-35(43)55-37)28-5-13-32(53)14-6-28/h1-24,42-50,54-61H,25,51-53H2
  • InChiKey: PPZNVBQPXXPEPG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0032 0.0067 0.0066
Schistosoma mansoni gabp alpha 0.0064 0.0168 0.0167
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2967 0.9405 0.9405
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Echinococcus multilocularis 0.0015 0.0011 0.001
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0187 0.056 0.0559
Brugia malayi MH2 domain containing protein 0.0016 0.0017 0.0017
Echinococcus granulosus GA binding protein alpha chain 0.0064 0.0168 0.0167
Brugia malayi Cytochrome P450 family protein 0.0024 0.004 0.0041
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0067 0.1858
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.0071
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0026 0.0485
Onchocerca volvulus Huntingtin homolog 0.0126 0.0366 0.2164
Giardia lamblia Hypothetical protein 0.0187 0.056 0.0535
Loa Loa (eye worm) hypothetical protein 0.0032 0.0067 0.0067
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0025
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0187 0.056 0.0559
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0032 0.0067 0.1858
Loa Loa (eye worm) hypothetical protein 0.0082 0.0226 0.0226
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0044 0.0106 0.0105
Mycobacterium ulcerans fatty-acid-CoA ligase 0.011 0.0315 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0026 0.0485
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0341
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Giardia lamblia hypothetical protein 0.0187 0.056 0.0535
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0032 0.0067 0.0071
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0541 0.1685 0.1685
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.3154 1 1
Brugia malayi hypothetical protein 0.0126 0.0366 0.0388
Loa Loa (eye worm) hypothetical protein 0.0092 0.0257 0.0257
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0092 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.011 0.0315 0.0315
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Treponema pallidum sodium- and chloride- dependent transporter 0.0541 0.1685 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0092 0.0257 0.0257
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0258 0.0258
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0187 0.056 0.2658
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0017 0.0017
Onchocerca volvulus 0.0092 0.0257 0.1519
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0371 0.037
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0032 0.0067 0.1858
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Brugia malayi MH2 domain containing protein 0.0016 0.0017 0.0017
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0001 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Loa Loa (eye worm) hypothetical protein 0.0187 0.056 0.056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0032 0.0067 0.1858
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0187 0.056 0.2658
Loa Loa (eye worm) RNA binding protein 0.0128 0.0371 0.0371
Brugia malayi Calcitonin receptor-like protein seb-1 0.014 0.041 0.0434
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Schistosoma mansoni smad1 5 8 and 0.0016 0.0017 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0258 0.0257
Loa Loa (eye worm) hypothetical protein 0.0092 0.0257 0.0257
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0001 0.0001
Toxoplasma gondii propionate-CoA ligase 0.0032 0.0067 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.011 0.0315 0.0315
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0187 0.056 0.0559
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0212 0.6616
Onchocerca volvulus 0.0058 0.0151 0.089
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.3154 1 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0032 0.0067 0.0067
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0067 0.0273
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0371 0.037
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0041 0.0041
Schistosoma mansoni smad 0.0016 0.0017 0.0016
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0187 0.056 0.0594
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0187 0.056 0.0559
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0032 0.0067 0.0273
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0067 0.0273
Schistosoma mansoni hypothetical protein 0.0833 0.2615 0.2614
Echinococcus granulosus smad 0.0016 0.0017 0.0016
Brugia malayi Cytochrome P450 family protein 0.0024 0.004 0.0041
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0032 0.0067 0.1858
Loa Loa (eye worm) pigment dispersing factor receptor c 0.014 0.041 0.041
Echinococcus multilocularis geminin 0.0169 0.0502 0.0501
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0212 0.6616
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.011 0.0315 1
Echinococcus multilocularis Smad4 0.0016 0.0017 0.0016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.0026
Schistosoma mansoni acetyl-CoA synthetase 0.0032 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0001
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0187 0.056 0.0594
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0001 0.0001
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0187 0.056 0.0559
Leishmania major 4-coumarate:coa ligase-like protein 0.011 0.0315 0.1471
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0162 0.4966
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0102 0.0288 0.0287
Schistosoma mansoni thyroid hormone receptor 0.012 0.0347 0.0346
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.014 0.041 0.0434
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0041
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0026
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Echinococcus granulosus GPCR family 2 0.0044 0.0106 0.0105
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0663 0.2075 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0187 0.056 0.2658
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Entamoeba histolytica hypothetical protein 0.0102 0.0288 0.9097
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0082 0.0226 0.0226
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0092 0.0257 0.0272
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Brugia malayi cytochrome P450 0.0015 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0058 0.0151 0.015
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0017 0.0016
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0187 0.056 0.056
Onchocerca volvulus 0.0092 0.0257 0.1519
Echinococcus granulosus Smad4 0.0016 0.0017 0.0016
Schistosoma mansoni cpg binding protein 0.0062 0.0161 0.016
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.0734 0.0734
Schistosoma mansoni sodium/chloride dependent transporter 0.0092 0.0257 0.0256
Schistosoma mansoni intermediate filament proteins 0.0024 0.0041 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0067 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0111 0.0319 0.0318
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.011 0.0315 1
Trypanosoma brucei hypothetical protein, conserved 0.0187 0.056 0.2658
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0371 0.037
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0067 0.1858
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.056 0.2658
Loa Loa (eye worm) PDE1B protein 0.0187 0.056 0.056
Schistosoma mansoni Smad4 0.0016 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0096 0.0269 0.0268
Leishmania major 4-coumarate:coa ligase-like protein 0.011 0.0315 0.1471
Echinococcus granulosus tar DNA binding protein 0.0128 0.0371 0.037
Schistosoma mansoni cytochrome P450 0.0015 0.0011 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.056 0.2658
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0092 0.0257 0.0272
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0032 0.0067 0.1858
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0032 0.0067 0.1858
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0044 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0082 0.0226 0.0226
Leishmania major acetyl-CoA synthetase, putative 0.0032 0.0067 0.0273
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0032 0.0067 0.1858
Loa Loa (eye worm) hypothetical protein 0.0092 0.0257 0.0257
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 0.2658
Echinococcus granulosus lamin 0.0024 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0187 0.056 0.0594
Echinococcus granulosus serotonin transporter 0.0541 0.1685 0.1685
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0371 0.037
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0187 0.056 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0162 0.0161
Onchocerca volvulus 0.0032 0.0067 0.0395
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0187 0.056 0.2658
Loa Loa (eye worm) hypothetical protein 0.0032 0.0067 0.0067
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0371 0.0371
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0067 0.1858
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0092 0.0257 0.0256
Schistosoma mansoni cpg binding protein 0.0062 0.0161 0.016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0187 0.056 0.0594
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0162 0.4966
Loa Loa (eye worm) hypothetical protein 0.0541 0.1685 0.1685
Onchocerca volvulus 0.0032 0.0067 0.0395
Loa Loa (eye worm) hypothetical protein 0.0187 0.056 0.056
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0026 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0258 0.0257
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0067 0.0071
Loa Loa (eye worm) hypothetical protein 0.0126 0.0366 0.0366
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0064 0.0168 0.0168
Entamoeba histolytica acyl-CoA synthetase, putative 0.011 0.0315 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0074 0.0074
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0092 0.0257 0.0256
Loa Loa (eye worm) cytochrome P450 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.014 0.041 0.041
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0041 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.056 0.2658
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0032 0.0067 0.1858
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0212 0.6616
Brugia malayi TAR-binding protein 0.0128 0.0371 0.0393
Entamoeba histolytica hypothetical protein 0.0102 0.0288 0.9097
Trichomonas vaginalis antibiotic synthetase, putative 0.0032 0.0067 0.1095
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0341
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0162 0.0161
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.004 0.0944
Schistosoma mansoni hypothetical protein 0.0102 0.0288 0.0287
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0032 0.0067 0.1858
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0032 0.0067 0.0056
Plasmodium vivax amine transporter, putative 0.0092 0.0257 0.4329
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0187 0.056 0.2658
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0315 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0187 0.056 0.0559
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0541 0.1685 0.1685
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) norepinephrine transporter 0.0541 0.1685 0.1685
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0067 0.0273
Loa Loa (eye worm) hypothetical protein 0.0092 0.0257 0.0257
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0102 0.0288 0.9097
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Echinococcus multilocularis lamin dm0 0.0024 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0226 0.0226
Loa Loa (eye worm) oxidoreductase 0.0032 0.0067 0.0067
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0032 0.0067 0.1858
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0258 0.0257
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0092 0.0257 0.0256
Entamoeba histolytica acyl-CoA synthetase, putative 0.011 0.0315 1
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.056 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0092 0.0257 0.0256
Toxoplasma gondii exonuclease III APE 0.0019 0.0026 0.0015
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0032 0.0067 0.0067
Brugia malayi intermediate filament protein 0.0024 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0187 0.056 0.2658
Brugia malayi Fli-1 protein 0.0194 0.0583 0.0619
Plasmodium falciparum acyl-CoA synthetase 0.0082 0.0226 0.3753
Leishmania major cytochrome p450-like protein 0.0024 0.004 0.0139
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0187 0.056 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0187 0.056 0.0559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0258 0.0257
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0187 0.056 1
Loa Loa (eye worm) CYP4Cod1 0.0024 0.004 0.004
Schistosoma mansoni sodium-dependent amino acid transporter 0.0092 0.0257 0.0256
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0317 0.0307
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0106 0.0106
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0092 0.0257 0.0256
Brugia malayi hypothetical protein 0.0102 0.0288 0.0306
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0187 0.056 0.2658
Loa Loa (eye worm) Smad1 0.0016 0.0017 0.0017
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Echinococcus granulosus intermediate filament protein 0.0024 0.0041 0.004
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Echinococcus granulosus lamin dm0 0.0024 0.0041 0.004
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.056 0.2658
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0092 0.0257 0.0272
Entamoeba histolytica hypothetical protein 0.0102 0.0288 0.9097
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0541 0.1685 0.1791
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Onchocerca volvulus Huntingtin homolog 0.0126 0.0366 0.2164
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0187 0.056 0.2658
Echinococcus multilocularis musashi 0.0024 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0126 0.0366 0.0366
Schistosoma mansoni transcription factor LCR-F1 0.0102 0.0288 0.0287
Echinococcus multilocularis dnaJ subfamily B 0.0833 0.2615 0.2614
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.0747 0.0747
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0162 0.0151
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0092 0.0257 0.0256
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0001 0.0001
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0092 0.0257 0.0246
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0162 0.073
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0187 0.056 0.2658
Schistosoma mansoni hypothetical protein 0.0169 0.0502 0.0501
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0067 0.1858
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0258 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0067 0.1858
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.011 0.0315 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0092 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0139
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0032 0.0067 0.1858
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0067 0.1858
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.2967 0.9405 0.9405
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0151 0.0151
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0162 0.0161
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0187 0.056 0.2658
Schistosoma mansoni lamin 0.0024 0.0041 0.004
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.004 0.0139
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0187 0.056 0.0559
Echinococcus multilocularis sodium and chloride dependent glycine 0.0092 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis GA binding protein alpha chain 0.0064 0.0168 0.0167
Schistosoma mansoni ets-related 0.0194 0.0583 0.0582
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0541 0.1685 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0032 0.0067 0.1095
Schistosoma mansoni smad1 5 8 and 0.0016 0.0017 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.011 0.0315 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0017 0.0017
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0187 0.056 0.0559
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0187 0.056 0.0559
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0032 0.0067 0.1858
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0067 0.1858
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0067 0.0071
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0092 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.011 0.0315 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0371 0.037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.0015 0.0011 0.0011
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0067 0.0273
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0092 0.0257 0.0256
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0092 0.0257 0.0256
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0162 0.0161
Echinococcus multilocularis GPCR, family 2 0.0044 0.0106 0.0105
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0032 0.0067 0.1858
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0032 0.0067 0.1858
Toxoplasma gondii hypothetical protein 0.0092 0.0257 0.0246
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Echinococcus multilocularis lamin 0.0024 0.0041 0.004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1659 0.5244 0.5244
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0011 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0022 0.0021
Plasmodium falciparum amino acid transporter, putative 0.0092 0.0257 0.4329
Plasmodium vivax phosphodiesterase gamma, putative 0.0187 0.056 1
Echinococcus granulosus dnaJ subfamily B 0.0833 0.2615 0.2614
Schistosoma mansoni hypothetical protein 0.0044 0.0106 0.0105
Echinococcus multilocularis cpg binding protein 0.0062 0.0161 0.016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0212 0.6616
Loa Loa (eye worm) hypothetical protein 0.0092 0.0257 0.0257
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0187 0.056 0.0559
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.3154 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Brugia malayi Cytochrome P450 family protein 0.0034 0.0074 0.0077
Onchocerca volvulus 0.0032 0.0067 0.0395
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0022 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0258 0.0257
Plasmodium vivax hypothetical protein, conserved 0.0092 0.0257 0.4329
Loa Loa (eye worm) hypothetical protein 0.1687 0.5334 0.5334
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.011 0.0315 1
Schistosoma mansoni hypothetical protein 0.0169 0.0502 0.0501
Loa Loa (eye worm) latrophilin receptor protein 2 0.0044 0.0106 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0315 1
Plasmodium falciparum transporter, putative 0.0092 0.0257 0.4329
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0001 0.0001
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0032 0.0067 0.1858
Onchocerca volvulus 0.0032 0.0067 0.0395
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0187 0.056 0.0559
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0187 0.056 0.0594
Trypanosoma brucei cytochrome P450, putative 0.0024 0.004 0.0139
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.2967 0.9405 1
Echinococcus granulosus tumor protein p63 0.0969 0.3049 0.3048
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0187 0.056 0.0559
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.056 0.2658
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0032 0.0067 0.1858
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Brugia malayi follicle stimulating hormone receptor 0.0246 0.0747 0.0794
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0162 0.4966
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0187 0.056 0.0559
Brugia malayi Smad1 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0092 0.0257 0.0257
Schistosoma mansoni cellular tumor antigen P53 0.0142 0.0416 0.0415
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0092 0.0257 0.0246
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.0734 0.0734
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.011 0.0315 1
Schistosoma mansoni hypothetical protein 0.0111 0.0319 0.0318
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0187 0.056 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0187 0.056 0.0559
Entamoeba histolytica acyl-coA synthetase, putative 0.011 0.0315 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.056 0.056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0044 0.0106 0.0111
Echinococcus granulosus sodium and chloride dependent glycine 0.0092 0.0257 0.0256
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0187 0.056 0.2658
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0102 0.0288 0.0287
Echinococcus multilocularis thyroid hormone receptor alpha 0.012 0.0347 0.0346
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Brugia malayi MH2 domain containing protein 0.0242 0.0734 0.078
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Mycobacterium ulcerans hypothetical protein 0.011 0.0315 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0092 0.0257 0.0257
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0371 0.037
Brugia malayi MH1 domain containing protein 0.0016 0.0017 0.0017
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0187 0.056 0.2658
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0111 0.0319 0.0318
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0082 0.0226 0.7086
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0541 0.1685 0.1685
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0011 0.001
Onchocerca volvulus 0.011 0.0315 0.1861
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2967 0.9405 0.9405
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0092 0.0257 0.0257
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Schistosoma mansoni hypothetical protein 0.0044 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.3154 1 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0032 0.0067 0.1858
Loa Loa (eye worm) hypothetical protein 0.0142 0.0416 0.0416
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0067 0.0071
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0022 0.0022
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0187 0.056 0.0559
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0067 0.1858
Brugia malayi AMP-binding enzyme family protein 0.011 0.0315 0.0333
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0067 0.1858
Plasmodium falciparum phosphodiesterase delta, putative 0.0187 0.056 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0092 0.0257 0.0256
Echinococcus multilocularis sodium and chloride dependent glycine 0.0092 0.0257 0.0256
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0269 0.0269
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0017 0.0016
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0663 0.2075 1
Leishmania major hypothetical protein, conserved 0.0187 0.056 0.2658
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0024 0.0041 0.0235
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0001 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0011 0.001
Leishmania major acetyl-CoA synthetase, putative 0.0032 0.0067 0.0273
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0032 0.0067 0.1858
Schistosoma mansoni hypothetical protein 0.0044 0.0106 0.0105
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0011 0.001
Plasmodium vivax acyl-CoA synthetase, putative 0.0082 0.0226 0.3753
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 0.2658
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.0071
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0005 0.0005
Toxoplasma gondii hypothetical protein 0.0092 0.0257 0.0246
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0053 0.1388
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.3154 1 1
Schistosoma mansoni lamin 0.0024 0.0041 0.004
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0032 0.0067 0.0273
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0032 0.0067 0.0066
Leishmania major 4-coumarate:coa ligase-like protein 0.011 0.0315 0.1471
Brugia malayi putative malonyl-CoA decarboxylase 0.1687 0.5334 0.5671
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0187 0.056 0.2658
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.011 0.0315 0.0333
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.011 0.0315 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0092 0.0257 0.0256
Echinococcus granulosus geminin 0.0169 0.0502 0.0501
Onchocerca volvulus 0.0142 0.0416 0.2465
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0001 0.0001
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0187 0.056 0.2658
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0092 0.0257 0.0256
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0187 0.056 0.0594
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.056 0.2658
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0092 0.0257 0.0256
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0082 0.0226 0.7086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0663 0.2075 1
Onchocerca volvulus 0.0092 0.0257 0.1519
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Brugia malayi CXXC zinc finger family protein 0.0058 0.0151 0.0159
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.1687 0.5334 1
Echinococcus granulosus cpg binding protein 0.0062 0.0161 0.016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0258 0.0273
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0032 0.0067 0.1443
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0187 0.056 0.0559
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0187 0.056 0.0559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0258 0.0257
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Brugia malayi latrophilin 2 splice variant baaae 0.0096 0.0269 0.0285
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0371 0.0393
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0044 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0082 0.0226 0.0226
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0187 0.056 0.0559
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Loa Loa (eye worm) fli-1 protein 0.0194 0.0583 0.0583
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0067 0.1858
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0026 0.0071
Loa Loa (eye worm) hypothetical protein 0.0541 0.1685 0.1685
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0092 0.0257 0.0246
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0067 0.1858
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0187 0.056 1
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0041 0.0042
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0032 0.0067 0.0056
Schistosoma mansoni thyroid hormone receptor 0.012 0.0347 0.0346
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0032 0.0067 0.0273
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0187 0.056 0.0559
Echinococcus multilocularis smad 0.0016 0.0017 0.0016
Brugia malayi RNA binding protein 0.0128 0.0371 0.0393
Brugia malayi Ets-domain containing protein 0.0064 0.0168 0.0178
Loa Loa (eye worm) hypothetical protein 0.011 0.0315 0.0315
Plasmodium falciparum phosphodiesterase gamma, putative 0.0187 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni smad1 5 8 and 0.0016 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0359 0.0358
Echinococcus multilocularis tumor protein p63 0.0969 0.3049 0.3048
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0032 0.0067 0.1858
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0017 0.0016
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0187 0.056 0.0559
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis serotonin transporter 0.0541 0.1685 0.1685
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.056 1
Brugia malayi hypothetical protein 0.0092 0.0257 0.0272
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0092 0.0257 0.0272
Leishmania major malonyl-coa decarboxylase-like protein 0.0663 0.2075 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0092 0.0257 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Onchocerca volvulus 0.0024 0.0041 0.0235
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Loa Loa (eye worm) serotonin transporter b 0.0541 0.1685 0.1685
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0187 0.056 0.0549
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0017 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0044 0.0106 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0067 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.056 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0092 0.0257 0.0256
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0092 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.004 0.004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0044 0.0106 0.0111
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0162 0.4966
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.3154 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0022 0.0022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.3154 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0315 1
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.004 0.0139
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0187 0.056 0.2658
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0187 0.056 0.0559
Brugia malayi Ets-domain containing protein 0.0064 0.0168 0.0178
Schistosoma mansoni hypothetical protein 0.0044 0.0106 0.0105
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0187 0.056 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0032 0.0067 0.0781
Brugia malayi MH1 domain containing protein 0.0016 0.0017 0.0017
Schistosoma mansoni sodium/chloride dependent transporter 0.0541 0.1685 0.1685
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0067 0.1858
Plasmodium vivax acetyl-CoA synthetase, putative 0.0032 0.0067 0.0781

Activities

Activity type Activity value Assay description Source Reference
MBC (functional) > 1.5 ug ml-1 Minimal bacterial concentration against Staphylococcus aureus was evaluated ChEMBL. 15261271
MIC (functional) = 1.5 ug ml-1 Minimal inhibitory concentration against Staphylococcus aureus was evaluated; Range = 1-1.5 ug/mL ChEMBL. 15261271

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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