Detailed information for compound 329995

Basic information

Technical information
  • TDR Targets ID: 329995
  • Name: N'-[5-[6-(3-chloroanilino)pyrazin-2-yl]pyridi n-3-yl]-N,N-dimethylpropane-1,3-diamine
  • MW: 382.89 | Formula: C20H23ClN6
  • H donors: 2 H acceptors: 3 LogP: 3.26 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCNc1cncc(c1)c1cncc(n1)Nc1cccc(c1)Cl)C
  • InChi: 1S/C20H23ClN6/c1-27(2)8-4-7-24-18-9-15(11-22-12-18)19-13-23-14-20(26-19)25-17-6-3-5-16(21)10-17/h3,5-6,9-14,24H,4,7-8H2,1-2H3,(H,25,26)
  • InChiKey: SEYTYFBRYYSXAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[5-[6-(3-chloroanilino)pyrazin-2-yl]-3-pyridyl]-N,N-dimethyl-propane-1,3-diamine
  • N'-[5-[6-(3-chloroanilino)-2-pyrazinyl]-3-pyridyl]-N,N-dimethylpropane-1,3-diamine
  • N'-[5-[6-[(3-chlorophenyl)amino]pyrazin-2-yl]pyridin-3-yl]-N,N-dimethyl-propane-1,3-diamine
  • 3-[[5-[6-(3-chloroanilino)pyrazin-2-yl]-3-pyridyl]amino]propyl-dimethyl-amine
  • N'-[5-[6-[(3-chlorophenyl)amino]pyrazin-2-yl]pyridin-3-yl]-N,N-dimethylpropane-1,3-diamine
  • N'-[5-[6-[(3-chlorophenyl)amino]pyrazin-2-yl]-3-pyridyl]-N,N-dimethyl-propane-1,3-diamine
  • N'-[5-[6-[(3-chlorophenyl)amino]-2-pyrazinyl]-3-pyridyl]-N,N-dimethylpropane-1,3-diamine
  • 3-[[5-[6-[(3-chlorophenyl)amino]pyrazin-2-yl]-3-pyridyl]amino]propyl-dimethyl-amine
  • Pyrazine-Pyridine Biheteroaryl 40

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0312 0.0348
Leishmania major casein kinase, putative 0.0055 0.0288 0.0806
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0109 0.0901 0.3307
Entamoeba histolytica protein kinase, putative 0.0254 0.2537 1
Trichomonas vaginalis AGC family protein kinase 0.0126 0.1097 0.4109
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0432 0.1405
Plasmodium falciparum DNA gyrase subunit B 0.0143 0.1282 0.25
Schistosoma mansoni protein kinase C mu 0.0132 0.1157 0.2035
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0115 0.0115
Echinococcus multilocularis neuroglian 0.0031 0.0024 0.0027
Echinococcus granulosus serine:threonine protein kinase N2 0.0126 0.1097 0.1955
Brugia malayi p70 ribosomal S6 kinase beta 0.0248 0.2476 0.2476
Echinococcus multilocularis epidermal growth factor receptor 0.032 0.3291 0.3674
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0112 0.0933 0.3473
Leishmania major protein kinase, putative 0.004 0.0118 0.0104
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0135 0.1192 0.2124
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0823 0.2987
Leishmania major mitochondrial DNA topoisomerase II 0.0144 0.1298 0.4983
Brugia malayi MH2 domain containing protein 0.011 0.0915 0.0915
Loa Loa (eye worm) hypothetical protein 0.0065 0.04 0.04
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0024 0.0024
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0312 0.0348
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0132 0.1157 0.1157
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.1097 0.1927
Echinococcus multilocularis basement membrane specific heparan sulfate 0.005 0.0231 0.0258
Echinococcus multilocularis calcium activated potassium channel 0.0083 0.0608 0.0678
Plasmodium falciparum calcium-dependent protein kinase 4 0.004 0.0118 0.0001
Echinococcus granulosus Diacylglycerol kinase theta 0.0034 0.0051 0.0091
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0093 0.0103
Leishmania major casein kinase II, putative 0.0084 0.0614 0.2157
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0049 0.022 0.022
Echinococcus multilocularis protein kinase shaggy 0.0112 0.0933 0.1041
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.1493 0.2635
Trypanosoma brucei cdc2-related kinase 3 0.0102 0.0823 0.2987
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0432 0.1387
Entamoeba histolytica protein kinase, putative 0.0128 0.112 0.4408
Echinococcus granulosus myotubularin protein 13 0.0039 0.0113 0.0201
Brugia malayi phosphoinositide-dependent protein kinase I 0.0065 0.0407 0.0407
Entamoeba histolytica casein kinase, putative 0.0055 0.0288 0.1122
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0117 0.0175
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0251 0.2511 0.4476
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0407 0.1284
Brugia malayi Casein kinase II, alpha chain 0.0084 0.0614 0.0614
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0118 0.0103
Entamoeba histolytica diacylglycerol kinase, putative 0.0034 0.0051 0.0189
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0614 0.2134
Echinococcus granulosus aurora kinase A 0.0128 0.112 0.1996
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0312 0.0897
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0261 0.0689
Brugia malayi serine/threonine-protein kinase 6 0.0128 0.112 0.112
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0081 0.0587 0.0587
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0548 0.0612
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0175 0.1647 0.1647
Schistosoma mansoni unc-13 (munc13) 0.0035 0.0065 0.0082
Echinococcus multilocularis rho associated protein kinase 0.0305 0.3123 0.3487
Schistosoma mansoni serine/threonine protein kinase 0.0305 0.3123 0.555
Echinococcus granulosus NCK adaptor protein 0.0039 0.0115 0.0205
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.0118 0.021
Giardia lamblia Kinase, STE STE20 0.0068 0.0442 0.1356
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0057 0.0312 0.0897
Brugia malayi diacylglycerol kinase 0.0034 0.0051 0.0051
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0914 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0288 0.048
Loa Loa (eye worm) hypothetical protein 0.0114 0.0961 0.0961
Plasmodium falciparum casein kinase 1 0.0055 0.0288 0.0365
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0055 0.0288 0.0288
Onchocerca volvulus 0.0305 0.3123 0.7888
Trypanosoma cruzi aurora B kinase, putative 0.0128 0.112 0.4251
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0035 0.0065 0.0116
Brugia malayi serine/threonine kinase 12 0.0128 0.112 0.112
Brugia malayi Protein kinase domain containing protein 0.0102 0.0823 0.0823
Loa Loa (eye worm) hypothetical protein 0.0079 0.0559 0.0559
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0614 0.2134
Giardia lamblia Aurora kinase 0.0128 0.112 0.4189
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0024 0.0024
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0197 0.1897 0.2118
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.2511 0.4457
Loa Loa (eye worm) hypothetical protein 0.0052 0.0258 0.0258
Onchocerca volvulus Serine\/threonine kinase homolog 0.0251 0.2511 0.6317
Echinococcus granulosus cyclin dependent kinase 1 0.0102 0.0823 0.1466
Onchocerca volvulus 0.008 0.058 0.1356
Echinococcus granulosus PAK box P21 Rho binding 0.0031 0.0019 0.0034
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0065 0.0407 0.0454
Echinococcus multilocularis PAK box P21 Rho binding 0.0031 0.0019 0.0022
Brugia malayi protein unc-22 0.0034 0.0051 0.0051
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.074 0.1319
Loa Loa (eye worm) hypothetical protein 0.0088 0.0665 0.0665
Echinococcus granulosus tyrosine protein kinase HCK 0.0055 0.0295 0.0525
Brugia malayi protein kinase C3,putative 0.0133 0.1172 0.1172
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0437 0.461 0.8215
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1647 0.2911
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0084 0.0614 0.1242
Loa Loa (eye worm) hypothetical protein 0.0049 0.0221 0.0221
Echinococcus multilocularis mitogen activated protein kinase 14 0.0142 0.1272 0.142
Echinococcus multilocularis roundabout 2 0.0081 0.0586 0.0654
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0044 0.0164 0.0291
Onchocerca volvulus Tyrosine kinase homolog 0.0378 0.3946 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0861 0.3179
Echinococcus multilocularis hypothetical protein 0.006 0.0351 0.0392
Echinococcus multilocularis serine:threonine protein kinase 38 0.0126 0.1097 0.1225
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0034 0.0051 0.0051
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0031 0.0019 0.0034
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0128 0.112 0.2306
Loa Loa (eye worm) hypothetical protein 0.0039 0.0115 0.0115
Trypanosoma cruzi casein kinase, putative 0.0055 0.0288 0.081
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.2511 0.9895
Entamoeba histolytica protein kinase, putative 0.0248 0.2476 0.9758
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0095 0.074 0.0826
Schistosoma mansoni tyrosine kinase 0.0095 0.074 0.1289
Entamoeba histolytica protein kinase, putative 0.0254 0.2537 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0095 0.074 0.1319
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.004 0.0117 0.0106
Loa Loa (eye worm) hypothetical protein 0.005 0.0231 0.0231
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0057 0.0312 0.0556
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0057 0.0312 0.0556
Schistosoma mansoni protein kinase 0.0084 0.0614 0.1064
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0095 0.074 0.0826
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0044 0.0164 0.0299
Echinococcus granulosus mitogen activated protein kinase 11 0.0142 0.1272 0.2267
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.1452 0.2562
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0057 0.0312 0.0897
Loa Loa (eye worm) hypothetical protein 0.0039 0.0112 0.0112
Echinococcus granulosus rho-associated protein kinase 1 0.0305 0.3123 0.5566
Schistosoma mansoni protein kinase 0.0048 0.0215 0.035
Echinococcus multilocularis ephrin type A receptor 4 A 0.0089 0.0682 0.0761
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.1097 0.1927
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0142 0.1272 0.1272
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0024 0.0024
Onchocerca volvulus 0.0049 0.0221 0.0436
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0251 0.2511 1
Echinococcus granulosus neuroglian 0.0031 0.0024 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.112 0.1969
Schistosoma mansoni growth factor receptor-bound protein 0.0039 0.0115 0.0171
Giardia lamblia Kinase, NEK 0.0119 0.1016 0.3754
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0126 0.1097 0.1955
Toxoplasma gondii AGC kinase 0.0248 0.2476 0.513
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0039 0.0116 0.0207
Brugia malayi ribosomal protein S6 kinase alpha 3 0.01 0.0803 0.0803
Plasmodium falciparum DNA topoisomerase 2 0.0095 0.0743 0.1342
Brugia malayi serine/threonine protein kinase 6 0.0128 0.112 0.112
Leishmania major DNA polymerase eta, putative 0.0041 0.0137 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.2444 0.4337
Toxoplasma gondii AGC kinase 0.0057 0.0312 0.0552
Echinococcus granulosus Immunoglobulin 0.005 0.0231 0.0412
Schistosoma mansoni tyrosine kinase 0.032 0.3291 0.585
Trichomonas vaginalis CK1 family protein kinase 0.0055 0.0288 0.0798
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0078 0.0547 0.0547
Plasmodium falciparum NIMA related kinase 1 0.0119 0.1016 0.1928
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Trypanosoma brucei protein kinase, putative 0.0044 0.0164 0.0291
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0065 0.0407 0.0407
Echinococcus granulosus nervana 2 0.0122 0.1048 0.1868
Echinococcus multilocularis protein kinase c iota type 0.0242 0.2403 0.2683
Plasmodium falciparum casein kinase 2, alpha subunit 0.0084 0.0614 0.1066
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0031 0.0019 0.0034
Toxoplasma gondii histone kinase SNF1, putative 0.004 0.0117 0.014
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0102 0.0823 0.0823
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.2511 0.9895
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0031 0.0024 0.0044
Loa Loa (eye worm) AUR protein kinase 0.0128 0.112 0.112
Entamoeba histolytica DNA topoisomerase II, putative 0.0095 0.0743 0.2918
Brugia malayi Protein kinase domain containing protein 0.0105 0.0861 0.0861
Echinococcus multilocularis mitogen activated protein kinase 3 0.0067 0.0432 0.0482
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0065
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.074 0.1319
Loa Loa (eye worm) hypothetical protein 0.0062 0.0366 0.0366
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0128 0.112 0.1251
Loa Loa (eye worm) TK/ABL protein kinase 0.0049 0.0221 0.0221
Echinococcus multilocularis roundabout 2 0.0031 0.0024 0.0027
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.074 0.0826
Echinococcus granulosus protein kinase c eta type 0.0034 0.0051 0.0091
Entamoeba histolytica hypothetical protein 0.0034 0.0051 0.0189
Schistosoma mansoni nephrin 0.0031 0.0024 0.0009
Entamoeba histolytica protein kinase, putative 0.0055 0.0288 0.1123
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0112 0.0933 0.3476
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0547 0.0944
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0039 0.0107 0.0107
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.074 0.1319
Echinococcus multilocularis serine:threonine protein kinase N2 0.0126 0.1097 0.1225
Entamoeba histolytica protein kinase, putative 0.0105 0.0861 0.3385
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.2511 0.9895
Giardia lamblia Kinase, AGC AKT 0.01 0.0803 0.2866
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0095 0.074 0.0826
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0429 0.4517 0.4517
Trichomonas vaginalis STE family protein kinase 0.0068 0.0442 0.1429
Schistosoma mansoni protein kinase 0.007 0.0457 0.0783
Schistosoma mansoni DNA polymerase eta 0.0041 0.0137 0.021
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0068 0.0442 0.1731
Loa Loa (eye worm) RasGEF domain-containing protein 0.0034 0.0051 0.0051
Trypanosoma cruzi cdc2-related kinase 1 0.0102 0.0823 0.3021
Schistosoma mansoni serine/threonine-protein kinase 0.0145 0.1306 0.23
Brugia malayi Protein kinase domain containing protein 0.0049 0.0221 0.0221
Trichomonas vaginalis AGC family protein kinase 0.0128 0.112 0.4204
Toxoplasma gondii AGC kinase 0.0057 0.0312 0.0552
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0141 0.1268 1
Trichomonas vaginalis AGC family protein kinase 0.0128 0.112 0.4204
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0908 0.159
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0055 0.0288 0.081
Echinococcus granulosus Protein kinase C brain isozyme 0.02 0.1935 0.3448
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2537 1
Trypanosoma brucei Casein kinase II 0.0084 0.0614 0.2134
Brugia malayi intracellular kinase 0.0112 0.0933 0.0933
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0245 0.2444 0.2729
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0614 0.2134
Echinococcus granulosus protein kinase shaggy 0.0112 0.0933 0.1662
Plasmodium falciparum protein kinase, putative 0.0044 0.0164 0.01
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Echinococcus granulosus serine:threonine protein kinase 3 0.0238 0.2362 0.4209
Onchocerca volvulus 0.0288 0.2927 0.7384
Mycobacterium ulcerans DNA gyrase subunit A 0.0452 0.4777 1
Entamoeba histolytica protein kinase , putative 0.0128 0.112 0.4408
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0102 0.0823 0.1466
Entamoeba histolytica protein kinase, putative 0.0054 0.0277 0.1079
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0145 0.1306 0.5017
Trypanosoma cruzi p21-activated kinase 3, putative 0.0039 0.0107 0.0065
Loa Loa (eye worm) TK protein kinase 0.0236 0.2337 0.2337
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2537 1
Schistosoma mansoni ephrin receptor 0.0089 0.0682 0.1184
Echinococcus multilocularis tyrosine kinase 0.0049 0.0221 0.0247
Echinococcus granulosus raf serine:threonine protein kinase 0.006 0.0349 0.0623
Giardia lamblia Kinase, AGC PKA 0.0139 0.1244 0.4708
Brugia malayi Protein kinase domain containing protein 0.0126 0.1097 0.1097
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0373 0.3893 0.4347
Loa Loa (eye worm) MH2 domain-containing protein 0.011 0.0915 0.0915
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2537 1
Trypanosoma brucei protein kinase, putative 0.0112 0.0933 0.3437
Trichomonas vaginalis AGC family protein kinase 0.0119 0.1016 0.3777
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0105 0.0861 0.3177
Echinococcus multilocularis twitchin 0.0031 0.0025 0.0027
Echinococcus multilocularis Immunoglobulin 0.005 0.0231 0.0258
Loa Loa (eye worm) hypothetical protein 0.008 0.058 0.058
Brugia malayi Protein kinase domain containing protein 0.0175 0.1647 0.1647
Echinococcus multilocularis activin receptor type 0.0044 0.0164 0.0183
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.0112 0.0125
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0139 0.1244 0.2567
Giardia lamblia Kinase, AGC PKA 0.0057 0.0312 0.0813
Loa Loa (eye worm) raf kinase 0.0034 0.0051 0.0051
Schistosoma mansoni protein kinase 0.007 0.0457 0.0783
Plasmodium falciparum calcium-dependent protein kinase 1 0.004 0.0118 0.0001
Loa Loa (eye worm) AUR protein kinase 0.0128 0.112 0.112
Loa Loa (eye worm) AUR protein kinase 0.0128 0.112 0.112
Schistosoma mansoni tyrosine kinase 0.0057 0.0318 0.0533
Schistosoma mansoni kinase 0.0269 0.2717 0.4824
Entamoeba histolytica hypothetical protein 0.0031 0.0019 0.0063
Entamoeba histolytica casein kinase 1, putative 0.0055 0.0288 0.1122
Echinococcus granulosus tyrosine protein kinase shark 0.0049 0.0221 0.0394
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Schistosoma mansoni cell adhesion molecule 0.0031 0.0024 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0081 0.0587 0.0656
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.004 0.0118 0.0141
Loa Loa (eye worm) hypothetical protein 0.0117 0.0996 0.0996
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0672 0.1167
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0067 0.0432 0.0805
Echinococcus granulosus serine threonine protein kinase nrc 0.0139 0.1244 0.2218
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Onchocerca volvulus 0.0055 0.0288 0.0606
Entamoeba histolytica hypothetical protein 0.0105 0.0861 0.3385
Onchocerca volvulus 0.0049 0.0221 0.0436
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.004 0.0127 0.0142
Loa Loa (eye worm) TK/EGFR protein kinase 0.0525 0.5611 0.5611
Brugia malayi STE20-like kinase MST 0.0238 0.2362 0.2362
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0055 0.0288 0.0288
Schistosoma mansoni diacylglycerol kinase theta 0.0034 0.0051 0.0057
Echinococcus multilocularis unc 13 (munc13) 0.0035 0.0065 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0117 0.0175
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0238 0.2362 0.2362
Echinococcus granulosus nervana 2 0.0122 0.1048 0.1868
Leishmania major protein kinase A catalytic subunit isoform 2 0.0057 0.0312 0.0907
Brugia malayi Pleckstrin Homology Domain 0.0039 0.0113 0.0113
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.007 0.0457 0.051
Brugia malayi Protein kinase domain containing protein 0.0183 0.1736 0.1736
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.1736 0.3071
Echinococcus multilocularis casein kinase I alpha 0.0055 0.0288 0.0321
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0039 0.0116 0.0129
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0614 0.2134
Trypanosoma cruzi casein kinase, putative 0.0055 0.0288 0.081
Brugia malayi casein kinase 1, delta 0.0055 0.0288 0.0288
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0126 0.1097 0.1225
Schistosoma mansoni rac gtpase activating protein 0.0034 0.0051 0.0057
Plasmodium vivax unspecified product 0.0084 0.0614 0.1242
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.004 0.0118 0.0141
Echinococcus multilocularis epidermal growth factor receptor 0.0525 0.5611 0.6265
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0065 0.04 0.0713
Schistosoma mansoni tyrosine kinase 0.0294 0.2992 0.5316
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0209 0.2035 0.2035
Schistosoma mansoni tyrosine kinase 0.0049 0.0221 0.0361
Giardia lamblia Kinase, NEK 0.0119 0.1016 0.3754
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0085 0.0628 0.2188
Brugia malayi Fibronectin type III domain containing protein 0.0052 0.0258 0.0258
Echinococcus multilocularis 0.0154 0.1414 0.1579
Plasmodium falciparum calcium-dependent protein kinase 3 0.004 0.0118 0.0001
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0057 0.0312 0.0911
Giardia lamblia Kinase, CK1 Casein kinase 0.0055 0.0288 0.0711
Onchocerca volvulus 0.0338 0.3488 0.8826
Entamoeba histolytica protein kinase, putative 0.0055 0.0295 0.115
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0065 0.0407 0.0407
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.0118 0.021
Echinococcus granulosus Rac GTPase activating protein 1 0.0034 0.0051 0.0091
Trypanosoma brucei casein kinase I, isoform 2 0.0055 0.0288 0.0798
Echinococcus granulosus growth factor receptor bound protein 2 0.0039 0.0115 0.0205
Echinococcus multilocularis roundabout 2 0.0031 0.0024 0.0027
Giardia lamblia Kinase, CMGC CDK 0.0102 0.0823 0.2946
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0547 0.1859
Echinococcus granulosus roundabout 2 0.0031 0.0024 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0407 0.0692
Loa Loa (eye worm) hypothetical protein 0.008 0.058 0.058
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0039 0.0115 0.0115
Brugia malayi Protein kinase domain containing protein 0.0097 0.077 0.077
Trypanosoma cruzi SNF1-related protein kinases, putative 0.004 0.0117 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.1452 0.2562
Entamoeba histolytica cell division protein kinase 2, putative 0.0102 0.0823 0.3234
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0081 0.0587 0.1047
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Schistosoma mansoni protein kinase C mu 0.0034 0.0051 0.0057
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0452 0.4777 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0095 0.074 0.1319
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0055 0.0288 0.0513
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0349 0.059
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0056 0.0304 0.051
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0095 0.074 0.0826
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Schistosoma mansoni tyrosine kinase 0.0294 0.2999 0.5328
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0115 0.0115
Echinococcus granulosus tyrosine protein kinase ABL1 0.0049 0.0221 0.0394
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0031 0.0024 0.0027
Brugia malayi P38 map kinase family protein 2 0.0142 0.1272 0.1272
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.0933 0.3668
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0248 0.2476 0.2476
Echinococcus granulosus c-Jun N-terminal kinases 0.0245 0.2444 0.4356
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0407 0.1284
Echinococcus multilocularis raf serine:threonine protein kinase 0.006 0.0349 0.039
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0907 0.3332
Brugia malayi Hr1 repeat family protein 0.0126 0.1097 0.1097
Trypanosoma cruzi cdc2-related kinase 3 0.0102 0.0823 0.3021
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0049 0.0221 0.0247
Echinococcus multilocularis titin 0.0034 0.0051 0.0057
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0143 0.1282 0.2539
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.0112 0.0125
Trypanosoma cruzi cdc2-related kinase 3 0.0102 0.0823 0.3021
Trypanosoma cruzi polo-like protein kinase, putative 0.0251 0.2511 1
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0039 0.0107 0.0107
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0067 0.0432 0.1405
Entamoeba histolytica PH domain containing protein kinase, putative 0.0062 0.0373 0.146
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0055 0.0288 0.0322
Trichomonas vaginalis STE family protein kinase 0.007 0.0457 0.1491
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Echinococcus multilocularis Diacylglycerol kinase theta 0.0034 0.0051 0.0057
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0102 0.0823 0.0823
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0056 0.0304 0.0542
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0095 0.0743 0.1775
Loa Loa (eye worm) hypothetical protein 0.004 0.0117 0.0117
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0044 0.0164 0.0238
Plasmodium vivax protein kinase Crk2 0.0102 0.0823 0.168
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0105 0.0861 0.0861
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0312 0.0523
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0823 0.2987
Schistosoma mansoni tyrosine kinase 0.032 0.3291 0.585
Schistosoma mansoni hypothetical protein 0.006 0.0351 0.0593
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0432 0.1387
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0065 0.0407 0.0724
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Echinococcus multilocularis casein kinase I alpha 0.0055 0.0288 0.0321
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0055 0.0288 0.0513
Loa Loa (eye worm) hypothetical protein 0.005 0.0234 0.0234
Giardia lamblia Kinase, CMGC CDK 0.0102 0.0823 0.2946
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.007 0.0457 0.0815
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0049 0.0221 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0312 0.0523
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.004 0.0127 0.0226
Loa Loa (eye worm) hypothetical protein 0.0041 0.0137 0.0137
Schistosoma mansoni protein kinase 0.0197 0.1897 0.3358
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0407 0.1284
Trypanosoma cruzi DNA topoisomerase II, putative 0.0085 0.0628 0.2215
Entamoeba histolytica protein kinase, putative 0.004 0.0118 0.0452
Loa Loa (eye worm) hypothetical protein 0.007 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0052 0.0258 0.0258
Brugia malayi casein kinase I 0.0055 0.0288 0.0288
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0432 0.1387
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.007 0.0457 0.0815
Brugia malayi P21-Rho-binding domain containing protein 0.0031 0.0019 0.0019
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0095 0.0743 0.0743
Echinococcus granulosus serine:threonine protein kinase 0.0097 0.077 0.1373
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0056 0.0304 0.034
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0297 0.3026 0.5392
Trypanosoma cruzi casein kinase II, putative 0.0084 0.0614 0.216
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.051 0.0877
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0112 0.0933 0.0933
Brugia malayi SH2 domain containing protein 0.0049 0.0221 0.0221
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0066 0.0413 0.0704
Onchocerca volvulus 0.0114 0.0961 0.2336
Echinococcus granulosus serine:threonine protein kinase 0.0097 0.077 0.1373
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0119 0.1016 0.2087
Schistosoma mansoni inositol monophosphatase 0.0037 0.0093 0.0131
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0527 0.1777
Echinococcus multilocularis mitogen activated protein kinase 11 0.0142 0.1272 0.142
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0093 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0547 0.0944
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0039 0.0107 0.006
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0044 0.0164 0.0299
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Trichomonas vaginalis AGC family protein kinase 0.0132 0.1158 0.436
Echinococcus granulosus casein kinase I delta 0.0055 0.0288 0.0513
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0081 0.0587 0.0587
Schistosoma mansoni protein kinase 0.0044 0.0164 0.0258
Echinococcus multilocularis serine:threonine kinase SAD 1 0.004 0.0117 0.0131
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0312 0.0523
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0122 0.1048 0.1868
Echinococcus granulosus serine:threonine kinase SAD 1 0.004 0.0117 0.0209
Loa Loa (eye worm) TK protein kinase 0.0078 0.0548 0.0548
Echinococcus multilocularis neuroglian 0.0064 0.039 0.0436
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0024 0.0024
Echinococcus multilocularis dna polymerase eta 0.0041 0.0137 0.0153
Loa Loa (eye worm) AGC/NDR protein kinase 0.0126 0.1097 0.1097
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Chlamydia trachomatis DNA gyrase subunit A 0.0452 0.4777 1
Schistosoma mansoni serine/threonine-protein kinase 0.0145 0.1306 0.23
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.074 0.0826
Schistosoma mansoni serine/threonine kinase 0.0078 0.0547 0.0944
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0095 0.074 0.0826
Brugia malayi Protein kinase domain containing protein 0.0294 0.2999 0.2999
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0031 0.0024 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0429 0.4517 0.4517
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.004 0.0118 0.0118
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0209 0.2035 0.3626
Loa Loa (eye worm) hypothetical protein 0.0085 0.0627 0.0627
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0051 0.0057
Echinococcus multilocularis tyrosine protein kinase Blk 0.0078 0.0548 0.0612
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0183 0.1736 0.1736
Loa Loa (eye worm) hypothetical protein 0.0137 0.1217 0.1217
Plasmodium vivax DNA gyrase subunit B, putative 0.0143 0.1282 0.2647
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0144 0.1298 0.4985
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0057 0.0312 0.0911
Leishmania major protein kinase, putative 0.0068 0.0442 0.1444
Echinococcus granulosus neuroglian 0.0064 0.039 0.0696
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0068 0.0442 0.1731
Loa Loa (eye worm) hypothetical protein 0.0137 0.1217 0.1217
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0823 0.1437
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2537 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0093 0.0004
Echinococcus granulosus tyrosine protein kinase Lyn 0.0112 0.0936 0.1668
Schistosoma mansoni tyrosine kinase 0.0095 0.074 0.1289
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0067 0.0432 0.0432
Trichomonas vaginalis AGC family protein kinase 0.0128 0.112 0.4204
Schistosoma mansoni tyrosine kinase 0.0294 0.2992 0.5316
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0142 0.1272 0.4877
Brugia malayi WH1 domain containing protein 0.0031 0.0019 0.0019
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0057 0.0312 0.0911
Entamoeba histolytica protein kinase domain containing protein 0.0128 0.112 0.4408
Echinococcus multilocularis casein kinase ii subunit alpha 0.0084 0.0614 0.0686
Echinococcus granulosus contactin 0.0031 0.0024 0.0044
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0452 0.4777 1
Leishmania major protein kinase, putative 0.0044 0.0164 0.0294
Trichomonas vaginalis STE family protein kinase 0.0119 0.1016 0.3777
Loa Loa (eye worm) AGC/PKN protein kinase 0.0126 0.1097 0.1097
Chlamydia trachomatis DNA gyrase subunit B 0.0094 0.0727 0.0819
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0183 0.1736 0.1938
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0051 0.0051
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0139 0.1244 0.1389
Trichomonas vaginalis STE family protein kinase 0.007 0.0457 0.1491
Echinococcus granulosus roundabout 2 0.0081 0.0586 0.1045
Giardia lamblia DNA topoisomerase II 0.009 0.0692 0.2401
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Echinococcus multilocularis Glutaredoxin protein 5 0.0122 0.1048 0.1171
Echinococcus multilocularis death associated protein kinase 1 0.0821 0.8957 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.004 0.0118 0.021
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0112 0.0933 0.1041
Echinococcus granulosus Glutaredoxin protein 5 0.0122 0.1048 0.1868
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0031 0.0024 0.0027
Echinococcus granulosus tyrosine protein kinase Srms 0.0049 0.0221 0.0394
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0068 0.0442 0.1448
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0161 0.1493 0.1493
Echinococcus multilocularis serine:threonine protein kinase 0.0097 0.077 0.086
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0039 0.0107 0.0107
Echinococcus granulosus titin 0.0034 0.0051 0.0092
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0128 0.1113 0.1242
Schistosoma mansoni cell adhesion molecule 0.0067 0.0427 0.0729
Entamoeba histolytica protein kinase, putative 0.0041 0.0132 0.0508
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.004 0.0118 0.0198
Echinococcus granulosus calcium activated potassium channel 0.0083 0.0608 0.1083
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0297 0.3026 0.3378
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0175 0.1647 0.1647
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0143 0.1282 0.2609
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0051
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0245 0.2444 0.2444
Giardia lamblia Kinase, CMGC CK2 0.0084 0.0614 0.2076
Loa Loa (eye worm) hypothetical protein 0.005 0.0231 0.0231
Onchocerca volvulus 0.0049 0.0221 0.0436
Schistosoma mansoni vesicular amine transporter 0.0055 0.0292 0.0487
Brugia malayi SRC-1 0.0095 0.074 0.074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0236 0.2337 0.2337
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.0112 0.0199
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0051
Echinococcus granulosus casein kinase I alpha 0.0055 0.0288 0.0513
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0158 0.1452 0.1621
Brugia malayi hypothetical protein 0.0052 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0071 0.047 0.047
Plasmodium vivax casein kinase 1, putative 0.0055 0.0288 0.0555
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Schistosoma mansoni hypothetical protein 0.006 0.0351 0.0593
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0119 0.1016 0.2041
Onchocerca volvulus 0.0035 0.0065 0.0035
Loa Loa (eye worm) hypothetical protein 0.0079 0.0559 0.0559
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0183 0.1736 0.3094
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0057 0.0312 0.0897
Entamoeba histolytica casein kinase, putative 0.0084 0.0614 0.2411
Echinococcus multilocularis casein kinase I delta 0.0055 0.0288 0.0321
Schistosoma mansoni vav2 0.0062 0.0366 0.0619
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0126 0.1097 0.1955
Echinococcus granulosus casein kinase i 0.0055 0.0288 0.0513
Schistosoma mansoni inositol monophosphatase 0.0037 0.0093 0.0131
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0105 0.0861 0.3143
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0085 0.0628 0.2188
Schistosoma mansoni tyrosine kinase 0.0055 0.0296 0.0494
Echinococcus granulosus mitogen activated protein kinase 0.0067 0.0432 0.0769
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0907 0.3332
Echinococcus granulosus unc 13 munc13 0.0035 0.0065 0.0116
Schistosoma mansoni growth factor receptor-bound protein 0.0039 0.0115 0.0171
Brugia malayi Protein kinase domain containing protein 0.0049 0.0221 0.0221
Trypanosoma brucei polo-like protein kinase 0.0251 0.2511 0.9895
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0175 0.1647 0.2936
Echinococcus granulosus mitogen activated protein kinase 3 0.0067 0.0432 0.0769
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0039 0.0115 0.0171
Onchocerca volvulus 0.0036 0.008 0.0074
Brugia malayi Stress-activated protein kinase jnk-1 0.0245 0.2444 0.2444
Plasmodium falciparum DNA gyrase subunit A 0.0452 0.4777 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0142 0.1272 0.4879
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.1097 0.1927
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0035 0.0065 0.0073
Echinococcus multilocularis aurora kinase A 0.0128 0.112 0.1251
Echinococcus multilocularis mitogen activated protein kinase 11 0.0142 0.1272 0.142
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0933 0.3437
Echinococcus multilocularis cyclin dependent kinase 0.0102 0.0823 0.0919
Brugia malayi Protein kinase domain containing protein 0.0049 0.0221 0.0221
Brugia malayi Protein kinase c protein 2 0.0091 0.0703 0.0703
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0527 0.1777
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0031 0.0024 0.0027
Brugia malayi diacylglycerol kinase 0.0034 0.0051 0.0051
Echinococcus granulosus casein kinase I delta 0.0055 0.0288 0.0513
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0095 0.0743 0.1775
Trichomonas vaginalis AGC family protein kinase 0.0126 0.1097 0.4109
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0095 0.0743 0.0743
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.007 0.0457 0.0815
Trypanosoma cruzi casein kinase, putative 0.0055 0.0288 0.081
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.004 0.0117 0.0102
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.007 0.0457 0.051
Toxoplasma gondii DNA topoisomerase 2, putative 0.0095 0.0743 0.1463
Schistosoma mansoni hypothetical protein 0.0034 0.0051 0.0057
Loa Loa (eye worm) TK/INSR protein kinase 0.0294 0.2999 0.2999
Entamoeba histolytica cell division protein kinase 2, putative 0.0102 0.0823 0.3234
Echinococcus granulosus tyrosine protein kinase Blk 0.0078 0.0548 0.0977
Onchocerca volvulus 0.012 0.1023 0.2494
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0128 0.112 0.4408
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.1192 0.2097
Echinococcus granulosus casein kinase I alpha 0.0055 0.0288 0.0513
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0107 0.0157
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Schistosoma mansoni neuroglian 0.0031 0.0024 0.0009
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0122 0.1048 0.1171
Loa Loa (eye worm) TK/ROR protein kinase 0.004 0.0127 0.0127
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0118 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0933 0.3437
Loa Loa (eye worm) hypothetical protein 0.012 0.1023 0.1023
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0128 0.1113 0.1983
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0132 0.1157 0.1157
Echinococcus granulosus dual specificity 0.0105 0.0861 0.1534
Brugia malayi Protein kinase domain containing protein 0.0065 0.0407 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2537 1
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.004 0.0117 0.0117
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0067 0.0432 0.1387
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0067 0.0432 0.1405
Schistosoma mansoni protein kinase 0.0197 0.1897 0.3358
Brugia malayi Inositol-1 0.0037 0.0093 0.0093
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0112 0.0933 0.1633
Echinococcus granulosus serine/threonine protein kinase 0.0145 0.1306 0.2327
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0614 0.2134
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0312 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0908 0.159
Echinococcus multilocularis casein kinase I alpha 0.0055 0.0288 0.0321
Echinococcus multilocularis protein kinase c epsilon type 0.0161 0.1493 0.1667
Brugia malayi Protein kinase domain containing protein 0.0049 0.0221 0.0221
Echinococcus multilocularis casein kinase I delta 0.0055 0.0288 0.0321
Plasmodium falciparum serine/threonine protein kinase, putative 0.0128 0.112 0.2152
Loa Loa (eye worm) hypothetical protein 0.0057 0.0312 0.0312
Entamoeba histolytica diacylglycerol kinase, putative 0.0034 0.0051 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Entamoeba histolytica protein kinase, putative 0.007 0.0457 0.1791
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0049 0.0225 0.1447
Trypanosoma brucei SNF1-related protein kinases, putative 0.004 0.0117 0.0101
Giardia lamblia Kinase, NEK 0.0119 0.1016 0.3754
Trichomonas vaginalis STE family protein kinase 0.0048 0.0215 0.0502
Entamoeba histolytica protein kinase, putative 0.0065 0.0407 0.1591
Echinococcus multilocularis serine:threonine protein kinase 0.0097 0.077 0.086
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0118 0.0132
Echinococcus granulosus c src tyrosine kinase 0.0066 0.0413 0.0736
Giardia lamblia Kinase, CMGC GSK 0.0112 0.0933 0.3406
Echinococcus granulosus mitogen activated protein kinase 14 0.0142 0.1272 0.2267
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0055 0.0288 0.0288
Brugia malayi Protein kinase domain containing protein 0.0097 0.0768 0.0768
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0112 0.0933 0.1662
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0158 0.1452 0.2588
Loa Loa (eye worm) hypothetical protein 0.0052 0.0258 0.0258
Echinococcus multilocularis cyclin dependent kinase 5 0.0102 0.0823 0.0919
Echinococcus granulosus cyclin dependent kinase 5 0.0102 0.0823 0.1466
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0139 0.1239 0.1239
Echinococcus multilocularis N chimaerin 0.0056 0.0304 0.034
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0861 0.3179
Trichomonas vaginalis CK1 family protein kinase 0.0055 0.0288 0.0798
Schistosoma mansoni protein kinase C 0.0035 0.0065 0.0082
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0251 0.2511 0.2804
Schistosoma mansoni tyrosine kinase 0.0294 0.2992 0.5316
Entamoeba histolytica protein kinase, putative 0.0126 0.1097 0.4316
Trypanosoma brucei DNA topoisomerase ii 0.0144 0.1298 0.4931
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0117 0.0175
Loa Loa (eye worm) hypothetical protein 0.006 0.0351 0.0351
Leishmania major protein kinase A catalytic subunit isoform 1 0.0057 0.0312 0.0907
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0137 0.0186
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0373 0.3893 0.3893
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0209 0.2035 0.2272
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0067 0.0432 0.1402
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0432 0.1387
Plasmodium falciparum calcium-dependent protein kinase 5 0.004 0.0118 0.0001
Echinococcus multilocularis NCK adaptor protein 0.0039 0.0115 0.0128
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.004 0.0118 0.0118
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.004 0.0117 0.0102
Brugia malayi SH2 domain containing protein 0.0049 0.0221 0.0221
Onchocerca volvulus 0.0037 0.0092 0.0103
Brugia malayi C1-like domain containing protein 0.0132 0.1157 0.1157
Echinococcus multilocularis PAK box P21 Rho binding 0.0048 0.0215 0.024
Brugia malayi Furin-like cysteine rich region family protein 0.0525 0.5611 0.5611
Echinococcus multilocularis growth factor receptor bound protein 2 0.0039 0.0115 0.0128
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0823 0.1437
Plasmodium falciparum calcium-dependent protein kinase 2 0.004 0.0118 0.0001
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0144 0.1298 0.4985
Brugia malayi RhoGAP domain containing protein 0.0056 0.0304 0.0304
Echinococcus granulosus twitchin 0.0081 0.0586 0.1045
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0139 0.1244 0.2419
Brugia malayi Tyrosine-protein kinase abl-1 0.0066 0.0413 0.0413
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0142 0.1272 0.4826
Loa Loa (eye worm) hypothetical protein 0.0063 0.0383 0.0383
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0672 0.1167
Loa Loa (eye worm) SRC-1 0.0095 0.074 0.074
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0222 0.2178 0.2432
Echinococcus granulosus titin 0.0034 0.0051 0.0092
Echinococcus granulosus N chimaerin 0.0056 0.0304 0.0542
Schistosoma mansoni tyrosine kinase 0.0294 0.2999 0.5328
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0051
Brugia malayi Protein kinase domain containing protein 0.0049 0.0221 0.0221
Schistosoma mansoni Neurotrimin precursor (hNT) 0.005 0.0231 0.0379
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0102 0.0823 0.3018
Echinococcus granulosus protein kinase c iota type 0.0242 0.2403 0.4282
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0139 0.1244 0.2218
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0126 0.1097 0.1097
Schistosoma mansoni protein kinase 0.004 0.0118 0.0176
Plasmodium vivax DNA topoisomerase II, putative 0.0095 0.0743 0.1512
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0082 0.0602 0.1165
Onchocerca volvulus 0.0049 0.0221 0.0436
Entamoeba histolytica protein kinase domain containing protein 0.0105 0.0861 0.3385
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.2511 0.9895
Schistosoma mansoni DNA topoisomerase II 0.0095 0.0743 0.1294
Onchocerca volvulus 0.0049 0.0221 0.0436
Echinococcus granulosus casein kinase I alpha 0.0055 0.0288 0.0513
Echinococcus granulosus NDR protein kinase 0.0126 0.1097 0.1955
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0095 0.074 0.0826
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.2511 0.9895
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0095 0.0743 0.0829
Entamoeba histolytica protein kinase, putative 0.0105 0.0861 0.3385
Trypanosoma cruzi cdc2-related kinase 1 0.0102 0.0823 0.3021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0033
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0452 0.4777 1
Schistosoma mansoni nephrin 0.0066 0.0417 0.0711
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0078 0.0548 0.0977
Trichomonas vaginalis AGC family protein kinase 0.0126 0.1097 0.4109
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0106 0.0865 0.3192
Giardia lamblia Kinase, PLK 0.0251 0.2511 1
Brugia malayi serine/threonine-protein kinase PAK 7 0.0214 0.2086 0.2086
Schistosoma mansoni serine/threonine protein kinase 0.02 0.1935 0.3425
Brugia malayi RhoGAP domain containing protein 0.0034 0.0051 0.0051
Plasmodium vivax glycogen synthase kinase 3, putative 0.0112 0.0933 0.1912
Schistosoma mansoni tyrosine kinase 0.0222 0.2178 0.3861
Trypanosoma cruzi polo-like protein kinase, putative 0.0251 0.2511 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.011 0.0908 0.1619
Leishmania major DNA topoisomerase ii 0.0085 0.0628 0.2211
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0057 0.0312 0.0312
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0057 0.0312 0.0556
Brugia malayi P21-Rho-binding domain containing protein 0.0031 0.0019 0.0019
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0095 0.0743 0.1775
Brugia malayi Ras association domain family 1 isoform A 0.0034 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0097 0.077 0.077
Echinococcus granulosus epidermal growth factor receptor 0.0525 0.5611 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0062 0.0373 0.146
Schistosoma mansoni tyrosine kinase 0.018 0.1708 0.302
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0084 0.0614 0.0614
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0115 0.0115
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0197 0.1897 0.3381
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.0118 0.021
Plasmodium vivax calcium-dependent protein kinase, putative 0.004 0.0118 0.0198
Loa Loa (eye worm) TK/EPH protein kinase 0.0107 0.0877 0.0877
Brugia malayi protein kinase C II. 0.0161 0.1493 0.1493
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0068 0.0442 0.1429
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0117 0.0175
Brugia malayi Temporarily assigned gene name protein 59 0.0127 0.1108 0.1108
Schistosoma mansoni protein kinase 0.0128 0.112 0.1969
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0031 0.0024 0.0009
Echinococcus multilocularis tyrosine protein kinase shark 0.0049 0.0221 0.0247
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.004 0.0118 0.0198
Schistosoma mansoni tyrosine kinase 0.0525 0.5611 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0093 0.0165
Echinococcus multilocularis serine:threonine protein kinase 3 0.0238 0.2362 0.2637
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0128 0.112 0.4408
Schistosoma mansoni tyrosine kinase 0.0066 0.0413 0.0704
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0057 0.0312 0.0418
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0221 0.0221
Echinococcus granulosus defective proboscis extension response 0.005 0.0231 0.0412
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0158 0.1452 0.1621
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0093 0.0004
Brugia malayi Protein kinase domain containing protein 0.0168 0.1573 0.1573
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0258 0.0258
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0057 0.0312 0.0911
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.004 0.0117 0.0101
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0055 0.0288 0.0321
Echinococcus multilocularis protein kinase c eta type 0.0034 0.0051 0.0057
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0056 0.0304 0.0304
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0102 0.0823 0.0823
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0067 0.0432 0.1402
Brugia malayi RhoGEF domain containing protein 0.0034 0.0051 0.0051
Echinococcus multilocularis myosin iiia 0.0068 0.0442 0.0493
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0547 0.0944
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0093 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.2035 0.3604
Schistosoma mansoni nck2/grb4 0.0039 0.0115 0.0171
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.004 0.0117 0.0196
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0251 0.2511 0.2511
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0301 0.3076 0.3076
Entamoeba histolytica PH domain containing protein kinase, putative 0.0145 0.1306 0.514
Trypanosoma cruzi DNA topoisomerase II, putative 0.0085 0.0628 0.2215
Plasmodium falciparum protein kinase 5 0.0102 0.0823 0.1514
Onchocerca volvulus 0.0049 0.0221 0.0436
Echinococcus multilocularis tyrosine protein kinase Abl 0.0066 0.0413 0.0461
Echinococcus multilocularis mitogen activated protein kinase 0.0067 0.0432 0.0482
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0222 0.2178 0.3882
Giardia lamblia Kinase, CMGC MAPK 0.0067 0.0432 0.1313
Schistosoma mansoni atypical protein kinase C 0.0248 0.2471 0.4384
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0214 0.2086 0.2086
Trichomonas vaginalis AGC family protein kinase 0.0128 0.112 0.4204
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0095 0.074 0.1319
Loa Loa (eye worm) hypothetical protein 0.0263 0.2644 0.2644
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0126 0.1097 0.1225
Brugia malayi serine/threonine-protein kinase plk-2 0.0251 0.2511 0.2511
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0118 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.2511 0.9895
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0098 0.0776 0.0776
Entamoeba histolytica protein kinase, putative 0.004 0.0119 0.0456
Echinococcus multilocularis dual specificity 0.0105 0.0861 0.0961
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0135 0.1192 0.1331
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0058 0.0322 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Schistosoma mansoni diacylglycerol kinase theta 0.0034 0.0051 0.0057
Brugia malayi Protein kinase domain containing protein 0.0126 0.1097 0.1097
Trichomonas vaginalis DNA topoisomerase II, putative 0.0095 0.0743 0.266
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0312 0.0348
Echinococcus multilocularis c src tyrosine kinase 0.0066 0.0413 0.0461
Loa Loa (eye worm) hypothetical protein 0.0073 0.0493 0.0493
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0102 0.0823 0.1632
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.074 0.0826
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.032 0.3291 0.5864
Schistosoma mansoni protein kinase 0.004 0.0118 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.2511 0.9895
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0373 0.3893 0.6938
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0175 0.1647 0.1839
Entamoeba histolytica protein kinase 2, putative 0.0139 0.1244 0.4898
Schistosoma mansoni serine/threonine protein kinase 0.02 0.1935 0.3425
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Plasmodium vivax DNA gyrase subunit A, putative 0.0452 0.4777 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0128 0.112 0.4408
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0031 0.0019 0.0019
Entamoeba histolytica serine/threonine protein kinase, putative 0.0251 0.2511 0.9899
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0112 0.0933 0.1865
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2537 1
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0068 0.0442 0.1448
Brugia malayi Variant SH3 domain containing protein 0.0056 0.0304 0.0304
Echinococcus multilocularis serine:threonine protein kinase N2 0.0126 0.1097 0.1225
Onchocerca volvulus 0.0112 0.0933 0.2263
Trypanosoma brucei cdc2-related kinase 1 0.0102 0.0823 0.2987
Entamoeba histolytica serine/threonine protein kinase, putative 0.004 0.0117 0.045
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0031 0.0019 0.0022
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0222 0.2178 0.2432
Echinococcus multilocularis Rac GTPase activating protein 1 0.0034 0.0051 0.0057
Trypanosoma cruzi casein kinase, putative 0.0055 0.0288 0.081
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0197 0.19 0.3386
Giardia lamblia Kinase, STE STE20 0.007 0.0457 0.1419
Echinococcus multilocularis insulin receptor 0.0294 0.2999 0.3348
Loa Loa (eye worm) hypothetical protein 0.0062 0.0366 0.0366
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.077 0.2773
Schistosoma mansoni serine/threonine kinase 0.0126 0.1097 0.1927
Brugia malayi cell division control protein 2 homolog 0.0102 0.0823 0.0823
Echinococcus multilocularis rac serine:threonine kinase 0.0145 0.1306 0.1458
Schistosoma mansoni ste20-related kinase 0.0187 0.1785 0.3158
Echinococcus multilocularis casein kinase i 0.0055 0.0288 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0861 0.1505
Loa Loa (eye worm) hypothetical protein 0.0088 0.0665 0.0665
Echinococcus multilocularis Protein kinase C, brain isozyme 0.02 0.1935 0.216
Echinococcus multilocularis cyclin dependent kinase 1 0.0102 0.0823 0.0919
Schistosoma mansoni titin 0.0034 0.0051 0.0057
Echinococcus granulosus tyrosine protein kinase Src42A 0.0051 0.025 0.0445
Leishmania major protein kinase, putative 0.0128 0.112 0.4248
Echinococcus granulosus fibroblast growth factor receptor 4 0.0222 0.2178 0.3882
Schistosoma mansoni protein kinase 0.004 0.0118 0.0176
Toxoplasma gondii CMGC kinase, CK2 family 0.0084 0.0614 0.1191
Schistosoma mansoni protein kinase 0.0055 0.0288 0.048
Brugia malayi map kinase activated protein kinase protein 2 0.0373 0.3893 0.3893
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.011 0.0908 0.1014
Entamoeba histolytica protein kinase, putative 0.0128 0.112 0.4408
Entamoeba histolytica protein kinase, putative 0.0055 0.0288 0.1123
Trichomonas vaginalis STE family protein kinase 0.007 0.0457 0.1491
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0056 0.0304 0.051
Loa Loa (eye worm) transcription factor SMAD2 0.011 0.0915 0.0915
Schistosoma mansoni serine/threonine protein kinase 0.0373 0.3893 0.6927
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.0933 0.3668
Echinococcus granulosus dna polymerase eta 0.0041 0.0137 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0288 0.048
Brugia malayi Protein kinase domain containing protein 0.0078 0.0547 0.0547
Trichomonas vaginalis CK1 family protein kinase 0.0055 0.0288 0.0798
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0097 0.077 0.077
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0137 0.018
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.007 0.0457 0.051
Brugia malayi hypothetical protein 0.0049 0.0221 0.0221
Trypanosoma brucei protein kinase, putative 0.0067 0.0432 0.1387
Entamoeba histolytica SH2-protein kinase domain containing protein 0.004 0.0119 0.0456
Giardia lamblia Kinase, CMGC GSK 0.0112 0.0933 0.3406
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.004 0.0118 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0614 0.2134
Toxoplasma gondii aurora kinase 0.0128 0.112 0.2262
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0025 0.0009
Entamoeba histolytica protein kinase, putative 0.0112 0.0933 0.3668
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0142 0.1272 0.4879
Echinococcus multilocularis cyclin dependent kinase 1 0.0102 0.0823 0.0919
Echinococcus granulosus activin receptor type 0.0044 0.0164 0.0292
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0057 0.0312 0.0552
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0128 0.112 0.1996
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0175 0.1647 0.1647
Echinococcus granulosus ephrin type A receptor 4 A 0.0089 0.0682 0.1215
Echinococcus multilocularis serine threonine protein kinase 0.0167 0.1553 0.1734
Entamoeba histolytica protein kinase domain containing protein 0.0044 0.0164 0.0634
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.004 0.0118 0.0103
Entamoeba histolytica protein kinase, putative 0.0054 0.0277 0.1079
Loa Loa (eye worm) inositol-1 0.0037 0.0093 0.0093
Entamoeba histolytica protein kinase, putative 0.0048 0.0215 0.0837
Trypanosoma brucei aurora B kinase 0.0128 0.112 0.4204
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.004 0.0118 0.0198
Toxoplasma gondii casein kinase I 0.0055 0.0288 0.05
Brugia malayi Protein kinase domain containing protein 0.0254 0.2537 0.2537
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0823 0.2987
Loa Loa (eye worm) AGC/AKT protein kinase 0.0254 0.2537 0.2537
Echinococcus granulosus protein kinase c epsilon type 0.0161 0.1493 0.266
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0095 0.0743 0.1324
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0135 0.1192 0.1192
Onchocerca volvulus 0.0137 0.1217 0.2993
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0117 0.0101
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0102 0.0823 0.3018
Entamoeba histolytica p21-activated kinase 0.0075 0.0518 0.2033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0051
Chlamydia trachomatis DNA gyrase subunit B 0.0143 0.1282 0.2077
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0139 0.1244 0.4764
Entamoeba histolytica protein kinase domain containing protein 0.0084 0.0614 0.2411
Loa Loa (eye worm) CAMK protein kinase 0.0034 0.0051 0.0051
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0135 0.1192 0.1192
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0034 0.0051 0.0051
Brugia malayi Protein kinase domain 0.007 0.0457 0.0457
Echinococcus multilocularis tyrosine protein kinase Srms 0.0078 0.0548 0.0612
Loa Loa (eye worm) TK protein kinase 0.0055 0.0295 0.0295
Echinococcus multilocularis nervana 2 0.0122 0.1048 0.1171
Schistosoma mansoni adapter molecule crk 0.0039 0.0115 0.0171
Echinococcus granulosus tyrosine kinase 0.0049 0.0221 0.0394
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.005 0.0231 0.0379
Plasmodium falciparum glycogen synthase kinase 3 0.0112 0.0933 0.175
Echinococcus granulosus cyclin dependent kinase 0.0102 0.0823 0.1466
Brugia malayi Sex muscle abnormal protein 5 0.0039 0.0115 0.0115
Loa Loa (eye worm) TOPoisomerase family member 0.0095 0.0743 0.0743
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.0221 0.0859
Loa Loa (eye worm) hypothetical protein 0.0137 0.1217 0.1217
Echinococcus multilocularis tyrosine protein kinase HCK 0.0055 0.0295 0.0329
Brugia malayi Probable DNA topoisomerase II 0.0095 0.0743 0.0743
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0432 0.0737
Loa Loa (eye worm) AGC/PKA protein kinase 0.0057 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0113
Echinococcus granulosus roundabout 2 0.0031 0.0024 0.0044
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0118 0.0132
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0197 0.19 0.2122
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0107 0.0157
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0034 0.0051 0.0051
Trichomonas vaginalis STE family protein kinase 0.007 0.0457 0.1491
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0039 0.0107 0.0065
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0118 0.0132
Echinococcus granulosus insulin receptor 0.0294 0.2999 0.5344
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0112 0.0933 0.0933
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0137 0.0137
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0614 0.2134
Echinococcus granulosus tyrosine protein kinase Src42A 0.0095 0.074 0.1319
Echinococcus granulosus casein kinase ii subunit alpha 0.0084 0.0614 0.1095
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0051
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0158 0.1452 0.2588
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2537 1
Schistosoma mansoni tyrosine kinase 0.0066 0.0413 0.0704
Leishmania major protein kinase A catalytic subunit 0.0057 0.0312 0.0907
Echinococcus multilocularis Immunoglobulin 0.005 0.0231 0.0258
Schistosoma mansoni unc-13 (munc13) 0.0035 0.0065 0.0082
Echinococcus granulosus protein kinase C gamma type 0.0167 0.1553 0.2768
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0051 0.025 0.0279
Schistosoma mansoni cell adhesion molecule 0.0031 0.0024 0.0009
Trypanosoma cruzi casein kinase, putative 0.0055 0.0288 0.081
Brugia malayi putative serine/threonine kinase SADA gamma 0.004 0.0117 0.0117
Brugia malayi protein-tyrosine kinase 0.0078 0.0548 0.0548
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0057 0.0312 0.0606
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0432 0.1405
Loa Loa (eye worm) AGC/PKA protein kinase 0.0057 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0052 0.0261 0.0261
Brugia malayi ephrin receptor 1 precursor 0.0056 0.0304 0.0304
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.004 0.0118 0.0141
Echinococcus multilocularis myotubularin protein 13 0.0039 0.0113 0.0126
Brugia malayi Cam kinase protein 1 0.004 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0024
Echinococcus multilocularis nervana 2 0.0122 0.1048 0.1171
Echinococcus multilocularis mitogen activated protein kinase 14 0.0142 0.1272 0.142
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0452 0.4777 1
Brugia malayi Kinase associated domain 1 family protein 0.006 0.0351 0.0351
Mycobacterium ulcerans DNA gyrase subunit B 0.0143 0.1282 0.2539
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0049 0.0221 0.0247
Echinococcus granulosus epidermal growth factor receptor 0.032 0.3291 0.5864
Trypanosoma brucei rac serine-threonine kinase, putative 0.0254 0.2537 1
Brugia malayi MAP kinase sur-1 0.0067 0.0432 0.0432
Entamoeba histolytica PH domain containing protein kinase, putative 0.0145 0.1306 0.514
Entamoeba histolytica hypothetical protein 0.0031 0.0019 0.0063
Trypanosoma cruzi Protein kinase B 0.0145 0.1306 0.5017
Loa Loa (eye worm) hypothetical protein 0.0171 0.1599 0.1599
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0175 0.1647 0.4098
Echinococcus granulosus tyrosine kinase 0.0078 0.0548 0.0977
Onchocerca volvulus 0.0063 0.0383 0.0852

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.87 Inhibitory concentration (experimental) against vascular endothelial growth factor receptor 2 ChEMBL. 16033269
IC50 (binding) = 0.135 uM Inhibition of vascular endothelial growth factor receptor 2 ChEMBL. 16033269
IC50 (binding) = 0.135 uM Inhibition of vascular endothelial growth factor receptor 2 ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of cyclin-dependent kinase 1 activity ChEMBL. 16033269
Log IC50 (binding) = 6.71 uM Inhibition of vascular endothelial growth factor receptor 2 ChEMBL. 16033269
Log IC50 (binding) = 6.87 uM Inhibitory concentration (experimental) against vascular endothelial growth factor receptor 2 ChEMBL. 16033269

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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