Detailed information for compound 334599

Basic information

Technical information
  • TDR Targets ID: 334599
  • Name: 2-(carboxymethylsulfanyl)-4-(2,4-dimethylphen yl)-4-oxobutanoic acid
  • MW: 296.339 | Formula: C14H16O5S
  • H donors: 2 H acceptors: 5 LogP: 2.14 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CSC(C(=O)O)CC(=O)c1ccc(cc1C)C
  • InChi: 1S/C14H16O5S/c1-8-3-4-10(9(2)5-8)11(15)6-12(14(18)19)20-7-13(16)17/h3-5,12H,6-7H2,1-2H3,(H,16,17)(H,18,19)
  • InChiKey: DSKWGGYQAFVEKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(carboxymethylsulfanyl)-4-(2,4-dimethylphenyl)-4-oxo-butanoic acid
  • 2-(carboxymethylthio)-4-(2,4-dimethylphenyl)-4-oxobutanoic acid
  • 2-(carboxymethylthio)-4-(2,4-dimethylphenyl)-4-keto-butyric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0085 0.0213
Loa Loa (eye worm) TYRA-2 protein 0.0084 0.0299 0.0494
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0392 0.2821
Giardia lamblia Cathepsin L precursor 0.0084 0.0301 0.2247
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0012 0.001 0.0013
Brugia malayi programmed cell death protein 6 0.0012 0.001 0.0013
Plasmodium vivax vivapain-3 0.0191 0.0733 0.3276
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0733 0.2042
Brugia malayi larval opioid receptor 0.0084 0.0299 0.0491
Loa Loa (eye worm) calpain 0.0103 0.0377 0.0623
Echinococcus multilocularis calpain 0.0103 0.0377 0.0375
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0799 0.3196 0.5278
Schistosoma mansoni cathepsin S (C01 family) 0.0084 0.0301 0.0494
Trypanosoma brucei Calpain-like protein CALP1.3 0.0031 0.0085 0.0437
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0084 0.0299 0.0491
Trypanosoma cruzi prefoldin subunit, putative 0.0062 0.0209 0.0564
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS18 0.0039 0.0119 0.2373
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0084 0.0301 0.132
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Schistosoma mansoni adenoreceptor 0.0084 0.0299 0.0491
Echinococcus multilocularis calpain family protein 1, d 0.0201 0.0775 0.0773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0084 0.0299 0.0491
Brugia malayi EF hand family protein 0.0012 0.001 0.0013
Echinococcus multilocularis cathepsin L 0.0084 0.0301 0.0299
Brugia malayi G-protein coupled receptor 0.0084 0.0299 0.0491
Brugia malayi hypothetical protein 0.0132 0.0493 0.0811
Leishmania major cathepsin L-like protease 0.0347 0.1366 0.7854
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0333 0.1306 0.2155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0299 0.0491
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0084 0.0301 0.132
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0191 0.0733 0.1207
Loa Loa (eye worm) SRC-1 0.001 0.0002 0.0003
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0085 0.0437
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0084 0.0299 0.0491
Loa Loa (eye worm) hypothetical protein 0.0241 0.0934 0.1543
Schistosoma mansoni dopamine-beta-monooxygenase 0.0799 0.3196 0.5278
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0377 0.062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0347 0.1366 0.6146
Onchocerca volvulus 0.0084 0.0299 0.2134
Loa Loa (eye worm) hypothetical protein 0.0107 0.0391 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0301 0.132
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0084 0.0301 0.0497
Brugia malayi Pepsin A precursor 0.0132 0.0493 0.0811
Plasmodium falciparum plasmepsin V 0.0132 0.0493 0.2191
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0085 0.0342
Loa Loa (eye worm) hypothetical protein 0.0201 0.0775 0.128
Echinococcus granulosus somatostatin receptor 0.0084 0.0299 0.0297
Loa Loa (eye worm) hypothetical protein 0.0039 0.0119 0.0196
Echinococcus granulosus neuropeptide s receptor 0.0084 0.0299 0.0297
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0509 0.0507
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0084 0.0299 0.0491
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0084 0.0299 0.0491
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0031 0.0085 0.0437
Schistosoma mansoni myosin xvIII 0.0084 0.0299 0.0491
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0303
Schistosoma mansoni hypothetical protein 0.0031 0.0085 0.0137
Leishmania major kinesin, putative 0.0072 0.0252 0.1402
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0213 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0301 0.132
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0084 0.0299 0.0491
Onchocerca volvulus 0.0084 0.0299 0.2134
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Loa Loa (eye worm) hypothetical protein 0.0132 0.0493 0.0814
Plasmodium vivax serine-repeat antigen (SERA) 0.0084 0.0301 0.132
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0392 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus granulosus allatostatin A receptor 0.0084 0.0299 0.0297
Echinococcus granulosus cathepsin L cysteine proteinase 0.0347 0.1366 0.1364
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0557 0.2216 0.2214
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0031 0.0085 0.0437
Onchocerca volvulus 0.0084 0.0299 0.2134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0299 0.0491
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0303
Trichomonas vaginalis AGC family protein kinase 0.0114 0.042 0.1858
Onchocerca volvulus Cathepsin F homolog 0.0347 0.1366 1
Echinococcus granulosus centrin 2 0.0012 0.001 0.0008
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0377 0.1038
Schistosoma mansoni biogenic amine (5HT) receptor 0.0084 0.0299 0.0491
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0301 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0301 0.132
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0085 0.0342
Echinococcus granulosus aurora kinase A 0.0114 0.042 0.0418
Trichomonas vaginalis hypothetical protein 0.0031 0.0085 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Leishmania major calpain family cysteine protease-like protein 0.0031 0.0085 0.0437
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0039 0.0119 0.0632
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0392 0.0645
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Loa Loa (eye worm) hypothetical protein 0.0084 0.0301 0.0497
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0084 0.0299 0.0491
Onchocerca volvulus Cathepsin L homolog 0.0347 0.1366 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0493 0.0811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Brugia malayi RNA binding protein 0.0063 0.0213 0.0348
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0301 0.132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0299 0.0491
Onchocerca volvulus 0.0347 0.1366 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Plasmodium vivax aspartyl protease, putative 0.0132 0.0493 0.2191
Plasmodium falciparum plasmepsin III 0.0132 0.0493 0.2191
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0085 0.0342
Brugia malayi cathepsin F-like cysteine proteinase 0.0084 0.0301 0.0494
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0347 0.1366 0.1364
Echinococcus granulosus cysteine protease 0.0191 0.0733 0.0731
Onchocerca volvulus 0.0347 0.1366 1
Echinococcus granulosus cathepsin L 0.0084 0.0301 0.0299
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0034 0.5
Loa Loa (eye worm) hypothetical protein 0.0274 0.1067 0.1762
Echinococcus multilocularis cathepsin L 0.0191 0.0733 0.0731
Giardia lamblia Cysteine protease 0.0084 0.0301 0.2247
Brugia malayi hypothetical protein 0.0025 0.006 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Plasmodium falciparum serine repeat antigen 8 0.0084 0.0301 0.132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.0733 0.3276
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0085 0.0342
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0301 0.0494
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0084 0.0299 0.2134
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Plasmodium falciparum serine repeat antigen 1 0.0084 0.0301 0.132
Trypanosoma brucei calpain, putative 0.0031 0.0085 0.0437
Schistosoma mansoni neuropeptide f receptor 76f 0.0084 0.0299 0.0491
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0084 0.0299 0.0297
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Echinococcus multilocularis neuronal calcium sensor 0.0012 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0107 0.0391 0.0646
Schistosoma mansoni neuropeptide receptor 0.0084 0.0299 0.0491
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0084 0.0301 0.0494
Schistosoma mansoni amine GPCR 0.0084 0.0299 0.0491
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0346
Schistosoma mansoni hypothetical protein 0.0084 0.0299 0.0491
Onchocerca volvulus 0.0084 0.0299 0.2134
Schistosoma mansoni neuropeptide receptor 0.0084 0.0299 0.0491
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0286 0.1117 0.1843
Trypanosoma brucei kinesin, putative 0.0072 0.0252 0.1402
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0301 0.132
Schistosoma mansoni hypothetical protein 0.0084 0.0299 0.0491
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0347 0.1366 0.6146
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0392 0.1734
Brugia malayi hypothetical protein 0.0084 0.0299 0.0491
Echinococcus granulosus tripartite motif containing protein 3 0.0039 0.0119 0.0117
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0887 0.3551 0.5863
Brugia malayi Fibronectin type III domain containing protein 0.0013 0.0012 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Plasmodium vivax plasmepsin IV, putative 0.0557 0.2216 1
Toxoplasma gondii aurora kinase 0.0114 0.042 0.1858
Onchocerca volvulus 0.0132 0.0493 0.3565
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0392 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0509 0.0838
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0557 0.2216 1
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Schistosoma mansoni peptidyl-glycine monooxygenase 0.1505 0.6054 1
Onchocerca volvulus 0.0084 0.0299 0.2134
Brugia malayi serine/threonine protein kinase 6 0.0114 0.042 0.069
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0084 0.0299 0.0494
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0439 0.1736 0.4875
Echinococcus granulosus orexin receptor type 2 0.0084 0.0299 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0347 0.1366 0.6146
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0013 0.0013 0.0011
Brugia malayi Melatonin receptor type 1A 0.0084 0.0299 0.0491
Echinococcus granulosus EF hand domain containing family member A2 0.0012 0.001 0.0008
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0084 0.0301 0.2148
Schistosoma mansoni opsin-like receptor 0.0084 0.0299 0.0491
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0084 0.0299 0.0297
Schistosoma mansoni alpha-1 adrenergic receptor 0.0084 0.0299 0.0491
Loa Loa (eye worm) RING finger protein nhl-1 0.0039 0.0119 0.0196
Schistosoma mansoni hypothetical protein 0.0084 0.0299 0.0491
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0392 0.0645
Plasmodium vivax prefoldin subunit 6, putative 0.0062 0.0209 0.0905
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0377 0.1038
Loa Loa (eye worm) hypothetical protein 0.017 0.0649 0.1072
Entamoeba histolytica cysteine proteinase, putative 0.0347 0.1366 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0084 0.0299 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0301 0.132
Brugia malayi calpain D 0.0031 0.0085 0.0137
Echinococcus multilocularis neuropeptides capa receptor 0.0084 0.0299 0.0297
Echinococcus granulosus calbindin 32 0.0012 0.001 0.0008
Onchocerca volvulus 0.0347 0.1366 1
Echinococcus granulosus g protein coupled receptor 0.0084 0.0299 0.0297
Brugia malayi Serotonin receptor 0.0084 0.0299 0.0491
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0406 0.1602 0.2644
Brugia malayi Cathepsin L-like precursor 0.0241 0.0934 0.154
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0084 0.0299 0.0297
Echinococcus granulosus programmed cell death protein 0.0012 0.001 0.0008
Echinococcus multilocularis fmrfamide receptor 0.0084 0.0299 0.0297
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0299 0.0491
Loa Loa (eye worm) neuropeptide F receptor 0.0084 0.0299 0.0494
Giardia lamblia Cathepsin L precursor 0.0084 0.0301 0.2247
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0084 0.0301 0.132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Plasmodium vivax unspecified product 0.0191 0.0733 0.3276
Leishmania major cathepsin L-like protease 0.0439 0.1736 1
Trypanosoma cruzi cysteine peptidase, putative 0.0439 0.1736 0.4875
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0213 0.0351
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0377 0.2129
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Trypanosoma brucei cysteine peptidase C (CPC) 0.0333 0.1306 0.7509
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0301 0.0494
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0031 0.0085 0.0342
Giardia lamblia Haloacid dehalogenase-like hydrolase family 0.0039 0.0119 0.0842
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.0391 0.1077
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0347 0.1366 0.6146
Echinococcus multilocularis calcium uptake protein 1 0.0012 0.001 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Echinococcus granulosus neuropeptides capa receptor 0.0084 0.0299 0.0297
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0392 0.2821
Schistosoma mansoni calmodulin 0.0012 0.001 0.0013
Schistosoma mansoni cathepsin D (A01 family) 0.1503 0.6046 0.9986
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0084 0.0299 0.0494
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0377 0.1038
Schistosoma mansoni neuronal calcium sensor 0.0012 0.001 0.0013
Plasmodium falciparum prefoldin subunit 6, putative 0.0062 0.0209 0.0905
Brugia malayi cathepsin L-like cysteine proteinase 0.0084 0.0301 0.0494
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0085 0.0213
Echinococcus granulosus biogenic amine 5HT receptor 0.0084 0.0299 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0509 0.0838
Echinococcus granulosus g protein coupled receptor 0.0084 0.0299 0.0297
Echinococcus multilocularis calmodulin 0.0012 0.001 0.0008
Echinococcus granulosus tm gpcr rhodopsin 0.0084 0.0299 0.0297
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0084 0.0301 0.132
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Loa Loa (eye worm) hypothetical protein 0.0241 0.0934 0.1543
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0114 0.042 0.3023
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0084 0.0299 0.0491
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0114 0.042 0.3023
Plasmodium falciparum calpain 0.0031 0.0085 0.0342
Leishmania major cathepsin L-like protease 0.0347 0.1366 0.7854
Entamoeba histolytica cysteine proteinase, putative 0.0191 0.0733 0.5331
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0191 0.0733 0.1207
Schistosoma mansoni neuronal calcium sensor 0.0012 0.001 0.0013
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0084 0.0299 0.0297
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.002
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0085 0.0213
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0084 0.0299 0.0494
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus multilocularis G-protein coupled receptor, putative 0.0084 0.0299 0.0297
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0493 0.0811
Schistosoma mansoni cell adhesion molecule 0.0016 0.0024 0.0037
Schistosoma mansoni centrin-related 0.0012 0.001 0.0013
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.006 0.0291
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0303
Onchocerca volvulus 0.0132 0.0493 0.3565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.0733 0.3276
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Leishmania major cysteine peptidase A (CPA) 0.0347 0.1366 0.7854
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0377 0.062
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0084 0.0301 0.132
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Echinococcus multilocularis brain tumor protein 0.0039 0.0119 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0084 0.0301 0.132
Loa Loa (eye worm) cathepsin B 0.0333 0.1306 0.2157
Leishmania major cathepsin L-like protease 0.0439 0.1736 1
Toxoplasma gondii calcium-dependent protein kinase 0.0013 0.0013 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0209 0.0905
Loa Loa (eye worm) aspartyl protease 6 0.0132 0.0493 0.0814
Echinococcus granulosus calpain A 0.0286 0.1117 0.1115
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0013 0.0013 0.0011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0084 0.0299 0.0297
Giardia lamblia Cathepsin B precursor 0.0333 0.1306 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0034 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0301 0.0494
Brugia malayi 6-phosphofructokinase 0.0107 0.0392 0.0645
Brugia malayi hypothetical protein 0.0084 0.0299 0.0491
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0084 0.0301 0.0497
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0084 0.0301 0.0494
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0085 0.0213
Loa Loa (eye worm) calpain 5 0.0072 0.0252 0.0416
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0213 0.0348
Loa Loa (eye worm) hypothetical protein 0.071 0.2835 0.4683
Brugia malayi Calmodulin-like protein 0.0012 0.001 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0427 0.0704
Brugia malayi hypothetical protein 0.0132 0.0493 0.0811
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0084 0.0299 0.0297
Echinococcus multilocularis EF hand domain containing family member A2 0.0012 0.001 0.0008
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0084 0.0301 0.132
Entamoeba histolytica cysteine protease, putative 0.0084 0.0301 0.2148
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0333 0.1306 0.7509
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0213
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0076 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0299 0.0491
Leishmania major cathepsin L-like protease 0.0347 0.1366 0.7854
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0213
Brugia malayi Cathepsin L-like precursor 0.0347 0.1366 0.2253
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0032
Echinococcus multilocularis neuropeptide s receptor 0.0084 0.0299 0.0297
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi calpain family protein 1 0.0274 0.1067 0.176
Schistosoma mansoni amine GPCR 0.0084 0.0299 0.0491
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0213 0.0211
Plasmodium vivax aspartyl proteinase, putative 0.0132 0.0493 0.2191
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0107 0.0391 0.0643
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0084 0.0301 0.132
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0493 0.0811
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0377 0.2129
Brugia malayi calpain family protein 1 0.0274 0.1067 0.176
Onchocerca volvulus 0.0084 0.0299 0.2134
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0191 0.0733 0.2042
Echinococcus multilocularis G protein coupled receptor 139 0.0084 0.0299 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0301 0.132
Trypanosoma cruzi cruzipain precursor, putative 0.0107 0.0391 0.1077
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Schistosoma mansoni hypothetical protein 0.0039 0.0119 0.0193
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0377 0.2129
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0557 0.2216 1
Echinococcus granulosus brain tumor protein 0.0039 0.0119 0.0117
Giardia lamblia Cathepsin L-like protease 0.0084 0.0301 0.2247
Schistosoma mansoni calmodulin 0.0012 0.001 0.0013
Schistosoma mansoni reticulocalbin 0.0012 0.001 0.0013
Echinococcus multilocularis cathepsin b 0.0887 0.3551 0.3549
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus multilocularis programmed cell death protein 0.0012 0.001 0.0008
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0076 0.1191
Toxoplasma gondii aspartyl protease ASP3 0.0132 0.0493 0.2191
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0333 0.1306 0.3661
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0301 0.132
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0299 0.0491
Entamoeba histolytica cysteine proteinase, putative 0.0191 0.0733 0.5331
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0347 0.1366 0.6146
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0012 0.0017
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0084 0.0301 0.132
Trypanosoma cruzi conserved protein 0.0031 0.0085 0.0213
Echinococcus granulosus g protein coupled receptor 0.0084 0.0299 0.0297
Giardia lamblia Cysteine protease 0.0084 0.0301 0.2247
Echinococcus multilocularis roundabout 2 0.0018 0.0034 0.0032
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0013 0.0013 0.0017
Entamoeba histolytica cysteine protease, putative 0.0084 0.0301 0.2148
Onchocerca volvulus 0.0084 0.0299 0.2134
Echinococcus multilocularis calpain A 0.0286 0.1117 0.1115
Brugia malayi B-box zinc finger family protein 0.0039 0.0119 0.0193
Brugia malayi serine/threonine kinase 12 0.0114 0.042 0.069
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0034 0.0068
Schistosoma mansoni opsin-like receptor 0.0084 0.0299 0.0491
Entamoeba histolytica calpain family cysteine protease, putative 0.0031 0.0085 0.0556
Brugia malayi cathepsin B-like cysteine proteinase 0.0887 0.3551 0.5863
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0301 0.132
Echinococcus multilocularis neuropeptides capa receptor 0.0084 0.0299 0.0297
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0107 0.0391 0.0646
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0377 0.1038
Onchocerca volvulus Cathepsin L homolog 0.0347 0.1366 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0084 0.0301 0.132
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Brugia malayi follicle stimulating hormone receptor 0.0084 0.0299 0.0491
Echinococcus granulosus neuropeptide Y receptor 0.0084 0.0299 0.0297
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0213
Plasmodium vivax unspecified product 0.0084 0.0301 0.132
Brugia malayi putative neuropeptide receptor NPR1 0.0084 0.0299 0.0491
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0377 0.1038
Onchocerca volvulus Tyrosine kinase homolog 0.0144 0.0544 0.3941
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0377 0.2129
Loa Loa (eye worm) AUR protein kinase 0.0114 0.042 0.0693
Echinococcus multilocularis g protein coupled receptor 0.0084 0.0299 0.0297
Schistosoma mansoni nephrin 0.0015 0.0022 0.0033
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS17 0.0039 0.0119 0.2373
Giardia lamblia Cathepsin B precursor 0.0084 0.0301 0.2247
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0392 0.0648
Onchocerca volvulus 0.0084 0.0299 0.2134
Brugia malayi AKH receptor 0.0084 0.0299 0.0491
Loa Loa (eye worm) B-box zinc finger family protein 0.0039 0.0119 0.0196
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0347 0.1366 0.1364
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0084 0.0299 0.0297
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi hypothetical protein 0.0084 0.0299 0.0491
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.001 0.0008
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0076 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0347 0.1366 0.6146
Entamoeba histolytica cysteine proteinase 2 0.0191 0.0733 0.5331
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0034 0.0068
Plasmodium falciparum plasmepsin IV 0.0557 0.2216 1
Echinococcus multilocularis somatostatin receptor 0.0084 0.0299 0.0297
Schistosoma mansoni hypothetical protein 0.0039 0.0119 0.0193
Loa Loa (eye worm) NCL-1 protein 0.0039 0.0119 0.0196
Echinococcus granulosus hypothetical protein 0.0084 0.0299 0.0297
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0084 0.0301 0.132
Entamoeba histolytica protein kinase, putative 0.0114 0.042 0.3023
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0286 0.1117 0.1115
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0084 0.0301 0.132
Entamoeba histolytica cysteine proteinase, putative 0.0241 0.0934 0.6817
Echinococcus multilocularis neuroglian 0.0012 0.0007 0.0005
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0084 0.0299 0.0494
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi calpain 7 0.0103 0.0377 0.062
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Onchocerca volvulus 0.0084 0.0299 0.2134
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0084 0.0299 0.0491
Brugia malayi ORL1-like opioid receptor 0.0084 0.0299 0.0491
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0392 0.5
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi G-protein coupled receptor 0.0084 0.0299 0.0491
Echinococcus multilocularis prefoldin subunit 6 0.0062 0.0209 0.0208
Trypanosoma brucei hypothetical protein 0.0031 0.0085 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Brugia malayi G protein-coupled receptor 0.0084 0.0299 0.0491
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0076 0.0492
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus multilocularis serotonin receptor 0.0084 0.0299 0.0297
Trichomonas vaginalis calpain, putative 0.0031 0.0085 0.0342
Brugia malayi aspartic protease BmAsp-2, identical 0.0132 0.0493 0.0811
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Brugia malayi GnHR receptor homolog 0.0084 0.0299 0.0491
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0034 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0392 0.1734
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0034 0.0186
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0084 0.0299 0.0494
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0034 0.0056
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0392 0.2216
Giardia lamblia Cathepsin B precursor 0.0084 0.0301 0.2247
Brugia malayi Cathepsin L-like cysteine proteinase 0.0241 0.0934 0.154
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0084 0.0299 0.0297
Brugia malayi cathepsin L-like precursor 0.0241 0.0934 0.154
Onchocerca volvulus Neuropeptide F receptor homolog 0.0084 0.0299 0.2134
Echinococcus multilocularis g protein coupled receptor 0.0084 0.0299 0.0297
Schistosoma mansoni cathepsin C 0.0084 0.0301 0.0494
Plasmodium falciparum plasmepsin II 0.0557 0.2216 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0303
Brugia malayi cathepsin L precursor 0.0084 0.0301 0.0494
Loa Loa (eye worm) hypothetical protein 0.0132 0.0493 0.0814
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0347 0.1366 0.2256
Brugia malayi hypothetical protein 0.0084 0.0299 0.0491
Plasmodium falciparum cysteine proteinase falcipain 1 0.0191 0.0733 0.3276
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0392 0.039
Entamoeba histolytica cysteine protease, putative 0.0084 0.0301 0.2148
Giardia lamblia Cathepsin L precursor 0.0084 0.0301 0.2247
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0392 0.0648
Echinococcus multilocularis calbindin 32 0.0012 0.001 0.0008
Giardia lamblia Cathepsin B precursor 0.0084 0.0301 0.2247
Echinococcus granulosus cathepsin L 0.0191 0.0733 0.0731
Brugia malayi hypothetical protein 0.0013 0.0012 0.0017
Brugia malayi hypothetical protein 0.0084 0.0299 0.0491
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0493 0.0811
Brugia malayi neuropeptide F receptor 0.0084 0.0299 0.0491
Schistosoma mansoni neuropeptide F-like receptor 0.0084 0.0299 0.0491
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0377 0.2129
Toxoplasma gondii aspartyl protease 0.0132 0.0493 0.2191
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0084 0.0301 0.132
Brugia malayi hypothetical protein 0.0084 0.0299 0.0491
Giardia lamblia Cathepsin L-like protease 0.0084 0.0301 0.2247
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0034 0.0139
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0191 0.0733 0.1207
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0084 0.0301 0.0494
Brugia malayi aspartic protease BmAsp-1, identical 0.0132 0.0493 0.0811
Brugia malayi Cathepsin L-like precursor 0.0241 0.0934 0.154
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0392 0.2821
Entamoeba histolytica cysteine proteinase, putative 0.0191 0.0733 0.5331
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0213 0.0348
Brugia malayi cathepsin Z-like cysteine proteinase 0.0084 0.0301 0.0494
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0213
Trypanosoma brucei Calpain-like protein 2 0.0031 0.0085 0.0437
Schistosoma mansoni cathepsin B (C01 family) 0.0084 0.0301 0.0494
Trypanosoma cruzi kinesin, putative 0.0072 0.0252 0.0683
Trichomonas vaginalis AGC family protein kinase 0.0114 0.042 0.1858
Giardia lamblia Cathepsin L precursor 0.0084 0.0301 0.2247
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0013 0.0013 0.0022
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0084 0.0299 0.0297
Echinococcus granulosus calpain 5 0.0103 0.0377 0.0375
Echinococcus granulosus roundabout 2 0.0018 0.0034 0.0032
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0034 0.0177
Entamoeba histolytica protein kinase, putative 0.0114 0.042 0.3023
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Plasmodium falciparum serine/threonine protein kinase, putative 0.0114 0.042 0.1858
Plasmodium falciparum plasmepsin X 0.0132 0.0493 0.2191
Loa Loa (eye worm) AUR protein kinase 0.0114 0.042 0.0693
Schistosoma mansoni cathepsin F (C01 family) 0.0347 0.1366 0.2253
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0084 0.0299 0.0491
Brugia malayi calcium-binding protein 0.0012 0.001 0.0013
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0301 0.0494
Brugia malayi putative neuropeptide receptor 0.0084 0.0299 0.0491
Echinococcus multilocularis g protein coupled receptor 0.0084 0.0299 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0084 0.0299 0.0491
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0392 0.039
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0084 0.0301 0.2148
Brugia malayi calpain 5 0.0031 0.0085 0.0137
Brugia malayi Eukaryotic aspartyl protease family protein 0.0132 0.0493 0.0811
Plasmodium vivax aspartyl proteinase, putative 0.0557 0.2216 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0084 0.0299 0.0491
Echinococcus multilocularis cysteine protease 0.0347 0.1366 0.1364
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0213 0.0348
Schistosoma mansoni biogenic amine receptor 0.0084 0.0299 0.0491
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0427 0.0704
Echinococcus granulosus EF HAND 1 calcium binding site 0.0012 0.001 0.0008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0084 0.0299 0.0297
Loa Loa (eye worm) G-protein coupled receptor 0.0084 0.0299 0.0494
Brugia malayi Cathepsin L-like precursor 0.0347 0.1366 0.2253
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.0509 0.0838
Echinococcus granulosus EF hand domain containing family member A2 0.0012 0.001 0.0008
Loa Loa (eye worm) cysteine protease 0.0347 0.1366 0.2256
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0557 0.2216 0.3658
Giardia lamblia Hypothetical protein 0.0084 0.0301 0.2247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0347 0.1366 0.6146
Brugia malayi Hypothetical RING finger protein F54G8.4 in chromosome III 0.0039 0.0119 0.0193
Echinococcus multilocularis cathepsin L cysteine protease 0.0347 0.1366 0.1364
Schistosoma mansoni opsin-like receptor 0.0084 0.0299 0.0491
Brugia malayi Papain family cysteine protease containing protein 0.0191 0.0733 0.1207
Entamoeba histolytica protein kinase domain containing protein 0.0114 0.042 0.3023
Mycobacterium tuberculosis Probable conserved membrane protein 0.0039 0.0119 0.2373
Plasmodium falciparum plasmepsin VII 0.0132 0.0493 0.2191
Giardia lamblia Aurora kinase 0.0114 0.042 0.3162
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0557 0.2216 0.366
Entamoeba histolytica cysteine proteinase, putative 0.0191 0.0733 0.5331
Echinococcus multilocularis calumenin 0.0012 0.001 0.0008
Entamoeba histolytica cysteine protease, putative 0.0084 0.0301 0.2148
Echinococcus multilocularis allatostatin A receptor 0.0084 0.0299 0.0297
Echinococcus multilocularis cathepsin L cysteine protease 0.0347 0.1366 0.1364
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0392 0.0648
Loa Loa (eye worm) EF hand family protein 0.0012 0.001 0.0016
Onchocerca volvulus 0.0347 0.1366 1
Plasmodium falciparum serine repeat antigen 4 0.0084 0.0301 0.132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0347 0.1366 0.6146
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0557 0.2216 0.2214
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0213
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0887 0.3551 1
Loa Loa (eye worm) hypothetical protein 0.0887 0.3551 0.5865
Echinococcus granulosus cathepsin l cysteine peptidase 0.0347 0.1366 0.1364
Schistosoma mansoni mitochondrial solute carrier 0.0012 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Schistosoma mansoni calpain-2 (C02 family) 0.0031 0.0085 0.0137
Schistosoma mansoni growth hormone secretagogue receptor 0.0084 0.0299 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0241 0.0934 0.4189
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0085 0.0213
Giardia lamblia Cathepsin L precursor 0.0084 0.0301 0.2247
Brugia malayi Papain family cysteine protease containing protein 0.0347 0.1366 0.2253
Trypanosoma cruzi cysteine peptidase, putative 0.0347 0.1366 0.3829
Schistosoma mansoni peptidylglycine monooxygenase 0.0039 0.0119 0.0193
Loa Loa (eye worm) hypothetical protein 0.0557 0.2216 0.366
Entamoeba histolytica prefoldin subunit 6, putative 0.0062 0.0209 0.1473
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0132 0.0493 0.2191
Echinococcus multilocularis fmrfamide receptor 0.0084 0.0299 0.0297
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0347 0.1366 0.6146
Schistosoma mansoni rab 0.0012 0.001 0.0013
Trypanosoma cruzi prefoldin subunit, putative 0.0062 0.0209 0.0564
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0392 0.2216
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0286 0.1117 0.1115
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0084 0.0299 0.0491
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0076 0.0515
Schistosoma mansoni Mername-AA248 (C02 family) 0.0103 0.0377 0.062
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0085 0.0213
Plasmodium falciparum plasmepsin VIII, putative 0.0132 0.0493 0.2191
Schistosoma mansoni cathepsin F (C01 family) 0.0241 0.0934 0.154
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Trypanosoma cruzi cysteine proteinase, putative 0.0191 0.0733 0.2042
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.006 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Echinococcus granulosus neuropeptide FF receptor 2 0.0084 0.0299 0.0297
Echinococcus multilocularis sex peptide receptor 0.0084 0.0299 0.0297
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0132 0.0493 0.0814
Trypanosoma cruzi major cysteine proteinase, putative 0.0176 0.0671 0.1869
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0012 0.001 0.0008
Entamoeba histolytica hypothetical protein 0.0039 0.0119 0.0805
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.0013
Leishmania major prefoldin subunit, putative 0.0062 0.0209 0.1157
Schistosoma mansoni cathepsin D (A01 family) 0.1503 0.6046 0.9986
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0084 0.0301 0.0494
Brugia malayi cathepsin F-like cysteine proteinase 0.0107 0.0391 0.0643
Brugia malayi B-box type zinc-finger protein ncl-1 0.0039 0.0119 0.0193
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.06 0.239 0.2389
Entamoeba histolytica cysteine protease, putative 0.0084 0.0301 0.2148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0733 0.4187
Onchocerca volvulus 0.0347 0.1366 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Toxoplasma gondii hypothetical protein 0.0031 0.0085 0.0342
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0299 0.0491
Echinococcus multilocularis neurocalcin 0.0012 0.001 0.0008
Echinococcus granulosus cathepsin L cysteine protease 0.0191 0.0733 0.0731
Schistosoma mansoni hypothetical protein 0.0084 0.0299 0.0491
Toxoplasma gondii exonuclease III APE 0.0018 0.0034 0.0109
Plasmodium falciparum plasmepsin IX 0.0132 0.0493 0.2191
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0034 0.0032
Trypanosoma brucei aurora B kinase 0.0114 0.042 0.2375
Echinococcus multilocularis neuropeptide receptor 0.0084 0.0299 0.0297
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0301 0.0494
Brugia malayi hypothetical protein 0.071 0.2835 0.4681
Giardia lamblia Cysteine protease 0.0084 0.0301 0.2247
Schistosoma mansoni reticulocalbin 0.0012 0.001 0.0013
Brugia malayi serine/threonine-protein kinase 6 0.0114 0.042 0.069
Schistosoma mansoni hypothetical protein 0.0039 0.0119 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0085 0.0342
Plasmodium vivax aspartyl protease, putative 0.0132 0.0493 0.2191
Brugia malayi Cathepsin L-like precursor 0.0107 0.0391 0.0643
Schistosoma mansoni ap endonuclease 0.0018 0.0034 0.0053
Brugia malayi B-box zinc finger family protein 0.0039 0.0119 0.0193
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0084 0.0301 0.132
Echinococcus granulosus calcium uptake protein 1 0.0012 0.001 0.0008
Onchocerca volvulus 0.0084 0.0299 0.2134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0509 0.0838
Plasmodium falciparum serine repeat antigen 6 0.0084 0.0301 0.132
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0333 0.1306 0.5876
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Plasmodium vivax vivapain-1 0.0191 0.0733 0.3276
Loa Loa (eye worm) hypothetical protein 0.0084 0.0301 0.0497
Brugia malayi hypothetical protein 0.0084 0.0299 0.0491
Echinococcus granulosus prefoldin subunit 6 0.0062 0.0209 0.0208
Brugia malayi Cathepsin L-like precursor 0.0347 0.1366 0.2253
Schistosoma mansoni neuropeptide receptor 0.0084 0.0299 0.0491
Entamoeba histolytica hypothetical protein 0.0084 0.0301 0.2148
Echinococcus multilocularis tachykinin peptides receptor 99D 0.248 1 1
Entamoeba histolytica protein kinase, putative 0.0073 0.0255 0.1813
Echinococcus granulosus neuroglian 0.0012 0.0007 0.0005
Brugia malayi hypothetical protein 0.0084 0.0299 0.0491
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus granulosus neuropeptide Y receptor 0.0084 0.0299 0.0297
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Schistosoma mansoni calpain (C02 family) 0.0103 0.0377 0.062
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0076 0.5
Trichomonas vaginalis calpain, putative 0.0031 0.0085 0.0342
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi EF hand family protein 0.0012 0.001 0.0013
Plasmodium falciparum serine repeat antigen 9 0.0084 0.0301 0.132
Echinococcus multilocularis dro:myosuppressin receptor 0.0084 0.0299 0.0297
Echinococcus multilocularis calpain 5 0.0103 0.0377 0.0375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.0301 0.132
Leishmania major hypothetical protein, conserved 0.0025 0.006 0.0291
Echinococcus granulosus 7TM GPCR rhodopsin 0.0084 0.0299 0.0297
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.0227
Loa Loa (eye worm) B-box zinc finger family protein 0.0039 0.0119 0.0196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.0301 0.132
Schistosoma mansoni hypothetical protein 0.0039 0.0119 0.0193
Brugia malayi fibroinase precursor 0.0084 0.0301 0.0494
Plasmodium falciparum cysteine proteinase falcipain 3 0.0347 0.1366 0.6146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0347 0.1366 0.6146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Entamoeba histolytica cysteine protease, putative 0.0347 0.1366 1
Giardia lamblia Hypothetical protein 0.0062 0.0209 0.1541
Echinococcus multilocularis cysteine protease 0.0347 0.1366 0.1364
Trypanosoma brucei calpain, putative 0.0031 0.0085 0.0437
Schistosoma mansoni amine GPCR 0.0084 0.0299 0.0491
Loa Loa (eye worm) hypothetical protein 0.0084 0.0301 0.0497
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0733 0.4187
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0301 0.0494
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0392 0.1734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Entamoeba histolytica cysteine protease, putative 0.0084 0.0301 0.2148
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0303
Plasmodium falciparum plasmepsin VI 0.0557 0.2216 1
Brugia malayi Dopamine receptor 0.0084 0.0299 0.0491
Plasmodium falciparum serine repeat antigen 7 0.0084 0.0301 0.132
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0076 0.0303
Trypanosoma cruzi major cysteine proteinase, putative 0.0084 0.0301 0.0823
Trypanosoma brucei Calpain-like protein 1.1 0.0031 0.0085 0.0437
Loa Loa (eye worm) calpain D 0.0031 0.0085 0.0141
Giardia lamblia Cathepsin B precursor 0.0084 0.0301 0.2247
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0377 0.2129
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0377 0.1038
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0213 0.0348
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Plasmodium falciparum serine repeat antigen 3 0.0084 0.0301 0.132
Echinococcus multilocularis g-protein coupled receptor 0.0084 0.0299 0.0297
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0114 0.042 0.1858
Leishmania major protein kinase, putative 0.0114 0.042 0.2375
Echinococcus granulosus alpha 1A adrenergic receptor 0.0084 0.0299 0.0297
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0005 0.0003
Onchocerca volvulus 0.0084 0.0301 0.2148
Onchocerca volvulus 0.0084 0.0299 0.2134
Echinococcus granulosus sex peptide receptor 0.0084 0.0299 0.0297
Echinococcus granulosus neuropeptide receptor A26 0.0084 0.0299 0.0297
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0084 0.0299 0.0297
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0085 0.0342
Echinococcus granulosus serotonin receptor 0.0084 0.0299 0.0297
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.006 0.0227
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0084 0.0301 0.2247
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0031 0.0085 0.0213
Brugia malayi hypothetical protein 0.0016 0.0024 0.0037
Echinococcus multilocularis brain tumor protein 0.0039 0.0119 0.0117
Entamoeba histolytica protein kinase , putative 0.0114 0.042 0.3023
Echinococcus granulosus calmodulin 0.0012 0.001 0.0008
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0085 0.0213
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Brugia malayi Immunoglobulin I-set domain containing protein 0.0154 0.0585 0.0963
Echinococcus granulosus neuropeptide receptor 0.0084 0.0299 0.0297
Loa Loa (eye worm) ctsf protein 0.0347 0.1366 0.2256
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0076 0.0303
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.002
Schistosoma mansoni neuronal calcium sensor 0.0012 0.001 0.0013
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Echinococcus granulosus twitchin 0.0013 0.0011 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Echinococcus granulosus G protein coupled receptor 139 0.0084 0.0299 0.0297
Echinococcus multilocularis neuropeptide FF receptor 2 0.0084 0.0299 0.0297
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0392 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0114 0.042 0.3023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.0301 0.132
Echinococcus granulosus calpain 0.0103 0.0377 0.0375
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0103 0.0377 0.2129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0347 0.1366 0.6146
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0034 0.0109
Echinococcus multilocularis cathepsin b 0.0887 0.3551 0.3549
Loa Loa (eye worm) hypothetical protein 0.0039 0.0119 0.0196
Schistosoma mansoni biogenic amine receptor 0.0084 0.0299 0.0491
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0493 0.0811
Echinococcus multilocularis orexin receptor type 2 0.0084 0.0299 0.0297
Echinococcus granulosus cathepsin b 0.0887 0.3551 0.3549
Schistosoma mansoni neuropeptide F-like receptor 0.0084 0.0299 0.0491
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0084 0.0299 0.0297
Trypanosoma cruzi kinesin, putative 0.0072 0.0252 0.0683
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0493 0.0811
Echinococcus multilocularis calmodulin 0.0012 0.001 0.0008
Brugia malayi KE2 family protein 0.0062 0.0209 0.0343
Echinococcus multilocularis tripartite motif containing protein 3 0.0039 0.0119 0.0117
Loa Loa (eye worm) hypothetical protein 0.0084 0.0301 0.0497
Schistosoma mansoni ef hand domain family member A2 0.0012 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi neuropeptide F receptor 0.0084 0.0299 0.0491
Schistosoma mansoni neuronal calcium sensor 0.0012 0.001 0.0013
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0084 0.0299 0.0297
Trichomonas vaginalis AGC family protein kinase 0.0114 0.042 0.1858
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi Tachykinin-like peptides receptor 99D 0.0084 0.0299 0.0491
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0887 0.3551 0.5863
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0509 0.0507
Trypanosoma cruzi cysteine proteinase, putative 0.0191 0.0733 0.2042
Onchocerca volvulus 0.017 0.0649 0.4717
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0377 0.1038
Plasmodium vivax aspartyl protease, putative 0.0132 0.0493 0.2191
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.0227
Trypanosoma cruzi aurora B kinase, putative 0.0114 0.042 0.1158
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0084 0.0299 0.0491
Brugia malayi Dopamine receptor protein 1 0.0084 0.0299 0.0491
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi Cathepsin L-like precursor 0.0347 0.1366 0.2253
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.1505 0.6054 1
Loa Loa (eye worm) G-protein coupled receptor 0.0084 0.0299 0.0494
Echinococcus granulosus calpain 7 C02 family 0.0103 0.0377 0.0375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Giardia lamblia Hypothetical protein 0.0039 0.0119 0.0842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0301 0.132
Onchocerca volvulus 0.0139 0.0522 0.3781
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0084 0.0299 0.0297
Giardia lamblia Cathepsin B precursor 0.0333 0.1306 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0299 0.0491
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0391 0.0646
Schistosoma mansoni centrin 0.0012 0.001 0.0013
Echinococcus granulosus tyrosine protein kinase Lyn 0.0011 0.0006 0.0004
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Echinococcus multilocularis calpain 7 (C02 family) 0.0103 0.0377 0.0375
Loa Loa (eye worm) hypothetical protein 0.0242 0.0941 0.1555
Entamoeba histolytica cysteine proteinase, putative 0.0347 0.1366 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0084 0.0299 0.0491
Brugia malayi Dopamine receptor protein 2 0.0084 0.0299 0.0491
Trypanosoma brucei antigen, putative 0.0103 0.0377 0.2129
Onchocerca volvulus 0.0084 0.0299 0.2134
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0213 0.0351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.0213 0.0351
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0034 0.0109
Plasmodium falciparum plasmepsin I 0.0557 0.2216 1
Giardia lamblia Cathepsin B precursor 0.0084 0.0301 0.2247
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0493 0.0811
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0084 0.0301 0.2247
Toxoplasma gondii cathepsin CPC1 0.0084 0.0301 0.132
Schistosoma mansoni biogenic amine receptor 0.0084 0.0299 0.0491
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0084 0.0299 0.0297
Brugia malayi TAR-binding protein 0.0063 0.0213 0.0348
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Schistosoma mansoni protein kinase 0.0114 0.042 0.069
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0114 0.042 0.0418
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0076 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.06 0.239 0.2389
Leishmania major cathepsin L-like protease 0.0347 0.1366 0.7854
Leishmania major calpain protease-like protein 0.0031 0.0085 0.0437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Schistosoma mansoni amine GPCR 0.0084 0.0299 0.0491
Brugia malayi RE15519p 0.0084 0.0299 0.0491
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0286 0.1117 0.1843
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0084 0.0301 0.0497
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus granulosus tm gpcr rhodopsin 0.0084 0.0299 0.0297
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0085 0.0213
Echinococcus multilocularis neuropeptide receptor A26 0.0084 0.0299 0.0297
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0039 0.0119 0.0632
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0084 0.0299 0.0297
Echinococcus granulosus cathepsin b 0.0887 0.3551 0.3549
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0076 0.0303
Echinococcus granulosus dro:myosuppressin receptor 0.0084 0.0299 0.0297
Schistosoma mansoni biogenic amine (5HT) receptor 0.0084 0.0299 0.0491
Echinococcus granulosus tar DNA binding protein 0.0063 0.0213 0.0211
Toxoplasma gondii preprocathepsin c precursor, putative 0.0084 0.0301 0.132
Entamoeba histolytica cysteine proteinase 1, putative 0.0191 0.0733 0.5331
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0377 0.2129
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0301 0.132
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0377 0.1038
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0142
Schistosoma mansoni hypothetical protein 0.0062 0.0209 0.0343
Schistosoma mansoni ap endonuclease 0.0018 0.0034 0.0053
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0213
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0084 0.0301 0.2247
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0392 0.108
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0084 0.0299 0.0297
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0084 0.0301 0.132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Trichomonas vaginalis AGC family protein kinase 0.0114 0.042 0.1858
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0103 0.0377 0.1038
Trypanosoma cruzi cruzipain precursor, putative 0.0439 0.1736 0.4875
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0084 0.0299 0.0491
Plasmodium falciparum serine repeat antigen 5 0.0084 0.0301 0.132
Onchocerca volvulus 0.0241 0.0934 0.6817
Brugia malayi sulfakinin receptor protein 0.071 0.2835 0.4681
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Giardia lamblia Cysteine protease 0.0084 0.0301 0.2247
Leishmania major protein kinase, putative 0.0013 0.0013 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.042 0.069
Schistosoma mansoni peptidylglycine monooxygenase 0.0799 0.3196 0.5278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0347 0.1366 0.6146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0084 0.0299 0.0491
Leishmania major cathepsin L-like protease 0.0347 0.1366 0.7854
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi cathepsin Z-like cysteine proteinase 0.0084 0.0301 0.0494
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0213
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0084 0.0299 0.0491
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Brugia malayi Serotonin receptor 0.0084 0.0299 0.0491
Toxoplasma gondii aspartyl protease ASP1 0.0557 0.2216 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0084 0.0299 0.0494
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0301 0.0494
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0213 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0301 0.132
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0392 0.1734
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0347 0.1366 0.2256
Plasmodium vivax calpain, putative 0.0103 0.0377 0.1666
Trypanosoma cruzi cysteine peptidase, putative 0.0439 0.1736 0.4875
Onchocerca volvulus 0.0347 0.1366 1
Echinococcus granulosus calumenin 0.0012 0.001 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0084 0.0299 0.0297
Schistosoma mansoni neuropeptide receptor 0.0084 0.0299 0.0491
Echinococcus granulosus neurocalcin 0.0012 0.001 0.0008
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0085 0.0213
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0154 0.0585 0.0966
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.1505 0.6054 0.6053
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0084 0.0301 0.132
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0012 0.001 0.0008
Giardia lamblia Cathepsin L precursor 0.0084 0.0301 0.2247
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.1505 0.6054 0.6053
Trypanosoma brucei cysteine peptidase, putative 0.0031 0.0085 0.0437
Schistosoma mansoni calmodulin related calcium binding protein 0.0012 0.001 0.0013
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0274 0.1067 0.176
Echinococcus granulosus neuropeptides capa receptor 0.0084 0.0299 0.0297
Brugia malayi 6-phosphofructokinase 0.0107 0.0392 0.0645
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0084 0.0299 0.0491
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Trypanosoma brucei Calpain-like protein 1.2 0.0031 0.0085 0.0437
Schistosoma mansoni calpain C (C02 family) 0.0103 0.0377 0.062
Plasmodium falciparum serine repeat antigen 2 0.0084 0.0301 0.132
Echinococcus granulosus g-protein coupled receptor 0.0084 0.0299 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0241 0.0934 0.4189
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0034 0.0109
Echinococcus granulosus fmrfamide receptor 0.0084 0.0299 0.0297
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0076 0.0303
Giardia lamblia Hypothetical protein 0.0084 0.0301 0.2247
Schistosoma mansoni amine GPCR 0.0084 0.0299 0.0491
Echinococcus granulosus cathepsin l1 0.0241 0.0934 0.0932
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0084 0.0299 0.0297
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0394 0.1554 0.2564
Giardia lamblia Cathepsin B precursor 0.0333 0.1306 1
Leishmania major cathepsin L-like protease 0.0439 0.1736 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Loa Loa (eye worm) hypothetical protein 0.0039 0.0119 0.0196
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0213
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Brugia malayi calpain 5 0.0072 0.0252 0.0413
Echinococcus multilocularis serotonin receptor 0.0084 0.0299 0.0297
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0012 0.001 0.0008
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0076 0.0303
Echinococcus granulosus neuropeptide receptor 0.0084 0.0299 0.0297
Onchocerca volvulus 0.0084 0.0299 0.2134
Schistosoma mansoni brat protein 0.0039 0.0119 0.0193
Echinococcus multilocularis centrin 2 0.0012 0.001 0.0008
Schistosoma mansoni histamine h1 receptor 0.0084 0.0299 0.0491
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0887 0.3551 0.5863
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0076 0.0303
Loa Loa (eye worm) hypothetical protein 0.0084 0.0301 0.0497
Toxoplasma gondii cathepsin B 0.0333 0.1306 0.5876
Leishmania major hypothetical protein, unknown function 0.0031 0.0085 0.0437
Brugia malayi hypothetical protein 0.0084 0.0299 0.0491
Onchocerca volvulus 0.0084 0.0299 0.2134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0509 0.0507
Loa Loa (eye worm) neuropeptide F receptor 0.0084 0.0299 0.0494
Plasmodium vivax serine-repeat antigen (SERA) 0.0084 0.0301 0.132
Echinococcus multilocularis hypothetical protein 0.0103 0.0377 0.0375
Giardia lamblia Encystation-specific protease 0.0084 0.0301 0.2247
Schistosoma mansoni memapsin-2 (A01 family) 0.0132 0.0493 0.0811
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0085 0.0342
Toxoplasma gondii cathepsin CPL 0.0347 0.1366 0.6146
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0084 0.0301 0.132
Loa Loa (eye worm) hypothetical protein 0.1505 0.6054 1
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.0013
Echinococcus multilocularis neuropeptide receptor 0.0084 0.0299 0.0297
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0084 0.0301 0.0494
Echinococcus granulosus 7tm_1 domain containing protein 0.0084 0.0299 0.0297
Echinococcus granulosus biogenic amine 5HT receptor 0.0084 0.0299 0.0297
Brugia malayi B-box type zinc-finger protein ncl-1 0.0039 0.0119 0.0193
Onchocerca volvulus 0.0347 0.1366 1
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0012 0.001 0.0013
Brugia malayi phosphofructokinase 0.0107 0.0392 0.0645
Echinococcus multilocularis rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Entamoeba histolytica calpain large subunit domain III containing protein 0.0072 0.0252 0.1785
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Loa Loa (eye worm) calmodulin-like protein 0.0012 0.001 0.0016
Schistosoma mansoni cathepsin s 0.0107 0.0391 0.0643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1366 0.6146
Echinococcus multilocularis neuropeptide Y receptor 0.0084 0.0299 0.0297
Echinococcus multilocularis neuropeptide Y receptor 0.0084 0.0299 0.0297
Plasmodium vivax vivapain-2 0.0347 0.1366 0.6146
Onchocerca volvulus Cathepsin L homolog 0.0084 0.0301 0.2148
Loa Loa (eye worm) hypothetical protein 0.0241 0.0934 0.1543
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0084 0.0301 0.2247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0347 0.1366 0.6146
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0084 0.0301 0.0497
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0493 0.0811
Loa Loa (eye worm) AUR protein kinase 0.0114 0.042 0.0693
Trypanosoma cruzi cysteine protease, putative 0.0191 0.0733 0.2042
Loa Loa (eye worm) programmed cell death protein 6 0.0012 0.001 0.0016
Onchocerca volvulus 0.0084 0.0299 0.2134
Brugia malayi Papain family cysteine protease containing protein 0.0191 0.0733 0.1207
Echinococcus granulosus rhodopsin orphan GPCR 0.0084 0.0299 0.0297
Loa Loa (eye worm) calpain family protein 1 0.0274 0.1067 0.1762
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0099
Echinococcus multilocularis EF hand domain containing family member A2 0.0012 0.001 0.0008
Echinococcus granulosus neuronal calcium sensor 0.0012 0.001 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0034 0.0053
Echinococcus multilocularis programmed cell death protein 0.0012 0.001 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0509 0.0507
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.0509 0.0841
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Onchocerca volvulus 0.0084 0.0299 0.2134
Onchocerca volvulus 0.0084 0.0299 0.2134
Schistosoma mansoni cathepsin F (C01 family) 0.0347 0.1366 0.2253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0439 0.1736 1
Entamoeba histolytica cysteine protease, putative 0.0191 0.0733 0.5331
Echinococcus granulosus calpain A 0.0103 0.0377 0.0375
Plasmodium vivax unspecified product 0.0107 0.0391 0.1729
Loa Loa (eye worm) fibroinase 0.0347 0.1366 0.2256
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0114 0.042 0.0418
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0142
Loa Loa (eye worm) hypothetical protein 0.0347 0.1366 0.2256
Plasmodium vivax plasmepsin V, putative 0.0132 0.0493 0.2191
Toxoplasma gondii prefoldin subunit 6, putative 0.0062 0.0209 0.0905
Loa Loa (eye worm) calpain family protein 1 0.0201 0.0775 0.128
Toxoplasma gondii cathepsin CPC2 0.0084 0.0301 0.132
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0494
Echinococcus granulosus cathepsin l1 0.0347 0.1366 0.1364
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0332 0.1304 0.3656
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0377 0.2129
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0887 0.3551 0.5863
Brugia malayi MH2 domain containing protein 0.0115 0.0427 0.0702
Trypanosoma brucei prefoldin subunit, putative 0.0062 0.0209 0.1157
Brugia malayi Cathepsin L-like precursor 0.0347 0.1366 0.2253
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0085 0.0437
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0377 0.1038
Echinococcus multilocularis aurora kinase A 0.0114 0.042 0.0418
Brugia malayi Cathepsin L-like precursor 0.0347 0.1366 0.2253
Trichomonas vaginalis calpain, putative 0.0031 0.0085 0.0342
Plasmodium vivax vivapain-2 0.0347 0.1366 0.6146
Loa Loa (eye worm) hypothetical protein 0.0799 0.3196 0.528
Leishmania major hypothetical protein, conserved 0.0031 0.0085 0.0437

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.417 Observed concentration of the compound that required to induce 50% decrease in HeLa cell survival ChEMBL. 16107160
IC50 (functional) = 3.83 umol/L Inhibitory concentration of the compound inducing 50% decrease in HeLa cell survival ChEMBL. 16107160
IC50 (functional) = 3.83 umol/L Inhibitory concentration of the compound inducing 50% decrease in HeLa cell survival ChEMBL. 16107160
Log 1/IC50 (functional) = 5.417 Observed concentration of the compound that required to induce 50% decrease in HeLa cell survival ChEMBL. 16107160
logP (ADMET) = 1.68 Partition coefficient (logP) ChEMBL. 16107160

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16107160

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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