Detailed information for compound 342174

Basic information

Technical information
  • TDR Targets ID: 342174
  • Name: 4-chloro-3-[3-[4-(2,3-dihydro-1,4-benzodioxin -8-yl)piperazin-1-yl]propyl]-1H-indole
  • MW: 411.924 | Formula: C23H26ClN3O2
  • H donors: 1 H acceptors: 0 LogP: 4.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc2c1c(CCCN1CCN(CC1)c1cccc3c1OCCO3)c[nH]2
  • InChi: 1S/C23H26ClN3O2/c24-18-5-1-6-19-22(18)17(16-25-19)4-3-9-26-10-12-27(13-11-26)20-7-2-8-21-23(20)29-15-14-28-21/h1-2,5-8,16,25H,3-4,9-15H2
  • InChiKey: MHRUHQSEUXHBOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-3-[3-[4-(2,3-dihydro-1,4-benzodioxin-8-yl)-1-piperazinyl]propyl]-1H-indole
  • 4-chloro-3-[3-[4-(2,3-dihydro-1,4-benzodioxin-8-yl)piperazino]propyl]-1H-indole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0094 0.1354
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0077 0.1111
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0021 0.0068
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0002 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0021 0.0406
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0012 0.0007 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0008
Schistosoma mansoni flap endonuclease-1 0.0051 0.0062 0.0895
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0006 0.0088
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0012 0.0007 0.0009
Echinococcus multilocularis nibrin 0.001 0.0002 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0105 0.0378
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0002 0.0035
Echinococcus multilocularis dna polymerase eta 0.0099 0.0131 0.1897
Echinococcus multilocularis PWWP domain containing protein 2A 0.0009 0.0002 0.0028
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0006 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0058 0.1122
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0014 0.027
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0038 0.0133
Brugia malayi RNA, U transporter 1 0.0098 0.013 0.0178
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0006 0.0088
Trichomonas vaginalis DNA polymerase eta, putative 0.01 0.0133 0.2858
Loa Loa (eye worm) XPG I-region family protein 0.0011 0.0005 0.01
Trypanosoma brucei DNA repair protein RAD2, putative 0.0011 0.0005 0.0012
Schistosoma mansoni sodium/chloride dependent transporter 0.0012 0.0007 0.0094
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0077 0.1485
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0052 0.1083
Echinococcus granulosus PWWP domain containing protein 2A 0.0009 0.0002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0117
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0012 0.0007 0.0094
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0005 0.0012
Echinococcus multilocularis muscleblind protein 0.0179 0.0245 0.3548
Onchocerca volvulus 0.0009 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0133 0.048
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0038 0.0553
Echinococcus multilocularis global transcription activator snf2l2 0.008 0.0104 0.1505
Schistosoma mansoni hypothetical protein 0.0033 0.0036 0.0522
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0021 0.007
Echinococcus granulosus dna polymerase eta 0.0099 0.0131 0.1897
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0011 0.0206
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0101 0.1455
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0024 0.0023 0.0076
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0024 0.008
Trypanosoma cruzi DNA polymerase eta, putative 0.0099 0.0131 0.0475
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0012 0.0007 0.0094
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.1808
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0036
Brugia malayi isocitrate dehydrogenase 0.0019 0.0016 0.0022
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0029 0.0581
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0008
Leishmania major DNA polymerase eta, putative 0.0048 0.0057 0.0204
Loa Loa (eye worm) MH2 domain-containing protein 0.0258 0.036 0.6955
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0016 0.0229
Schistosoma mansoni phd finger protein 0.0011 0.0005 0.0072
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0022 0.0073
Schistosoma mansoni importin beta-1 0.0034 0.0038 0.0553
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0088
Brugia malayi CXXC zinc finger family protein 0.0074 0.0096 0.0132
Echinococcus granulosus muscleblind protein 0.0179 0.0245 0.3548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0058 0.008
Entamoeba histolytica exonuclease, putative 0.0011 0.0005 0.0035
Schistosoma mansoni ap endonuclease 0.0022 0.0021 0.0304
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0006 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0133 0.048
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0006 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0133 0.048
Echinococcus multilocularis GPCR, family 2 0.0015 0.0011 0.0154
Schistosoma mansoni smad 0.0018 0.0014 0.0202
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0012 0.0007 0.0009
Loa Loa (eye worm) BRM protein 0.0051 0.0062 0.1205
Brugia malayi steroid hormone receptor 0.0012 0.0006 0.0008
Entamoeba histolytica hypothetical protein 0.001 0.0002 0.0009
Brugia malayi DKFZp564C0469 protein 0.001 0.0002 0.0003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.01 0.0133 0.2858
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0011 0.0005 0.0075
Giardia lamblia DNA repair protein RAD52 0.0752 0.107 0.3922
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0088
Giardia lamblia Exonuclease 1 0.0011 0.0005 0.001
Schistosoma mansoni hypothetical protein 0.0014 0.0009 0.0125
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0024 0.0082
Brugia malayi MH1 domain containing protein 0.0018 0.0014 0.0019
Loa Loa (eye worm) RNA binding protein 0.0061 0.0077 0.1485
Entamoeba histolytica hypothetical protein 0.0078 0.0101 0.0928
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0021 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0133 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0072 0.0256
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0004 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0059 0.0209
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0037
Entamoeba histolytica exonuclease, putative 0.0011 0.0005 0.0035
Brugia malayi hypothetical protein 0.0024 0.0024 0.0033
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0022 0.0073
Schistosoma mansoni hepatoma derived growth factor 0.0009 0.0002 0.0028
Plasmodium falciparum DNA repair protein RAD2, putative 0.0011 0.0005 0.001
Leishmania major mitochondrial DNA polymerase beta 0.0361 0.0507 0.1858
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0002 0.0002
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0015 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0133 0.048
Echinococcus granulosus sodium and chloride dependent glycine 0.0012 0.0007 0.0094
Echinococcus granulosus cpg binding protein 0.0076 0.0098 0.1423
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0012 0.0007 0.0094
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0012 0.0007 0.0094
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0002 0.0036
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0032 0.0035 0.0512
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0101 0.1455
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0014 0.027
Leishmania major DNA polymerase eta, putative 0.0099 0.0131 0.0475
Brugia malayi ImpB/MucB/SamB family protein 0.0099 0.0131 0.018
Trypanosoma brucei unspecified product 0.0051 0.0062 0.0222
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0046
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0011 0.0005 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0077 0.1111
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0016 0.0229
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0368 0.0517 1
Brugia malayi Importin beta-1 subunit 0.0034 0.0038 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.0459
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0012 0.0007 0.0016
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0046 0.0055 0.0794
Echinococcus multilocularis sodium and chloride dependent glycine 0.0012 0.0007 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0117
Brugia malayi RNA binding protein 0.0061 0.0077 0.0106
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0012
Entamoeba histolytica recQ family DNA helicase 0.0009 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0099 0.0131 0.2534
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0133 0.048
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0024 0.0079
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0015 0.0213
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0016 0.0051
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0024 0.008
Schistosoma mansoni hypothetical protein 0.0489 0.0691 1
Echinococcus granulosus global transcription activator snf2l2 0.008 0.0104 0.1505
Schistosoma mansoni SET domain protein 0.0032 0.0035 0.0512
Trypanosoma brucei unspecified product 0.0094 0.0123 0.0447
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0011 0.0005 0.0075
Loa Loa (eye worm) hypothetical protein 0.0133 0.018 0.3488
Trypanosoma brucei DNA polymerase IV, putative 0.0094 0.0123 0.0447
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0022 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0133 0.048
Entamoeba histolytica hypothetical protein 0.0078 0.0101 0.0928
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0062 0.0219
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0171 0.0234 0.0854
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0117
Loa Loa (eye worm) hypothetical protein 0.0033 0.0036 0.0698
Schistosoma mansoni cpg binding protein 0.0076 0.0098 0.1423
Echinococcus granulosus geminin 0.0203 0.028 0.4047
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0016 0.0022
Leishmania major telomerase reverse transcriptase, putative 0.1903 0.2723 1
Plasmodium falciparum amino acid transporter, putative 0.0012 0.0007 0.0015
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0004 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0126
Schistosoma mansoni hypothetical protein 0.0368 0.0517 0.7485
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0012
Schistosoma mansoni coup transcription factor 0.0012 0.0006 0.0088
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.0094 0.1808
Echinococcus multilocularis dna polymerase kappa 0.01 0.0133 0.1919
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0036 0.005
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.006
Giardia lamblia Flap structure-specific endonuclease 0.0056 0.007 0.0247
Mycobacterium ulcerans hypothetical protein 0.019 0.0262 0.5694
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0021 0.0072
Onchocerca volvulus 0.0046 0.0055 0.0055
Entamoeba histolytica deoxycytidyl transferase, putative 0.0074 0.0096 0.0882
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0361 0.0507 0.1858
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0005 0.0079
Brugia malayi MH1 domain containing protein 0.0018 0.0014 0.0019
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0006 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0077 0.1111
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0022 0.0439
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0015 0.002
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0011 0.0005 0.0066
Onchocerca volvulus 0.001 0.0002 0.0002
Trypanosoma brucei telomerase reverse transcriptase 0.1903 0.2723 1
Loa Loa (eye worm) glutaminase 2 0.0327 0.0458 0.8856
Loa Loa (eye worm) hypothetical protein 0.0034 0.0038 0.0739
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0012 0.0007 0.0094
Echinococcus multilocularis snurportin 1 0.0368 0.0517 0.7485
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0031 0.011
Echinococcus granulosus serotonin transporter 0.0073 0.0094 0.1354
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0056 0.007 0.0249
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0006 0.0006
Giardia lamblia hypothetical protein 0.0011 0.0005 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0062 0.0219
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0021 0.0408
Echinococcus granulosus replication factor c subunit 1 0.001 0.0002 0.0035
Echinococcus multilocularis geminin 0.0203 0.028 0.4047
Schistosoma mansoni smad1 5 8 and 0.0018 0.0014 0.0202
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0012 0.0007 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0088
Leishmania major DNA polymerase kappa, putative 0.0081 0.0105 0.0378
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0022 0.0073
Giardia lamblia DINP protein human, muc B family 0.0081 0.0105 0.0377
Brugia malayi MH2 domain containing protein 0.0018 0.0014 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0008
Brugia malayi MH2 domain containing protein 0.0018 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0055 0.106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0088
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.0133 0.048
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0006 0.0088
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0038 0.0133
Onchocerca volvulus 0.0073 0.0094 0.0094
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0056 0.007 0.0249
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0214 0.0296 0.276
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0012 0.0007 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0126
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0024 0.008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0006 0.0008
Plasmodium falciparum importin beta, putative 0.0034 0.0038 0.0132
Mycobacterium ulcerans glutaminase 0.0327 0.0458 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.0094 0.1808
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0016 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0133 0.048
Echinococcus multilocularis sodium and chloride dependent glycine 0.0012 0.0007 0.0094
Toxoplasma gondii hypothetical protein 0.0012 0.0007 0.0017
Schistosoma mansoni helicase 0.008 0.0104 0.1505
Onchocerca volvulus 0.0012 0.0007 0.0007
Brugia malayi MH2 domain containing protein 0.0258 0.036 0.0495
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0133 0.048
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0022 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0117
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0154
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0006 0.0088
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0125
Loa Loa (eye worm) PWWP domain-containing protein 0.0009 0.0002 0.0037
Brugia malayi hypothetical protein 0.0012 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0008
Echinococcus multilocularis PWWP domain containing protein 2A 0.0009 0.0002 0.0028
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0029 0.0099
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0094 0.0129
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0052 0.1083
Mycobacterium ulcerans DNA polymerase IV 0.01 0.0133 0.2858
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0006 0.0088
Entamoeba histolytica hypothetical protein 0.0078 0.0101 0.0928
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1903 0.2723 1
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0154
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0064
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0015 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0117
Plasmodium vivax DNA repair protein RAD2, putative 0.0011 0.0005 0.0014
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0015 0.0213
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0022 0.0073
Entamoeba histolytica DNA-repair protein, putative 0.0011 0.0005 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0117
Echinococcus multilocularis exonuclease 1 0.0011 0.0005 0.0075
Loa Loa (eye worm) BRM protein 0.0042 0.0048 0.0934
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0016 0.0229
Leishmania major hypothetical protein, conserved 0.0011 0.0005 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0021 0.007
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0012 0.0007 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0039 0.0557
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0012 0.0007 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0133 0.048
Onchocerca volvulus 0.0012 0.0007 0.0007
Plasmodium vivax importin-beta 2, putative 0.0034 0.0038 0.0135
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0016 0.0049
Toxoplasma gondii hypothetical protein 0.0012 0.0007 0.0017
Onchocerca volvulus 0.0074 0.0096 0.0096
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0014 0.0202
Loa Loa (eye worm) hypothetical protein 0.0179 0.0245 0.474
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0077 0.1485
Echinococcus multilocularis dnaJ subfamily B 0.0489 0.0691 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0206
Trypanosoma brucei DNA polymerase eta, putative 0.0099 0.0131 0.0475
Schistosoma mansoni terminal deoxycytidyl transferase 0.0074 0.0096 0.1384
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0088
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0088
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0006 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0088
Brugia malayi topoisomerase 0.001 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0058 0.1122
Echinococcus granulosus sodium and chloride dependent glycine 0.0012 0.0007 0.0094
Brugia malayi Disco-interacting protein 2 homolog 0.0046 0.0055 0.0076
Toxoplasma gondii exonuclease III APE 0.0022 0.0021 0.007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0074 0.0096 0.1384
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0081 0.0105 0.3617
Schistosoma mansoni exonuclease 0.0011 0.0005 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0126
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0038 0.0133
Loa Loa (eye worm) nuclear factor I 0.001 0.0003 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0072 0.0256
Loa Loa (eye worm) helicase DNA-binding protein 0.0014 0.0009 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0117
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0012 0.0007 0.0017
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0016 0.0051
Brugia malayi Flap endonuclease-1 0.0056 0.007 0.0096
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0022 0.0196
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0006 0.0088
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0006 0.0117
Echinococcus granulosus BRK domain containing protein 0.0014 0.0009 0.0125
Loa Loa (eye worm) glutaminase 0.0327 0.0458 0.8856
Schistosoma mansoni topbp1 0.001 0.0002 0.0035
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0101 0.0134 0.0484
Brugia malayi ecdysteroid receptor 0.0012 0.0006 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0088
Leishmania major DNA damage repair protein, putative 0.0023 0.0022 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0072 0.0256
Schistosoma mansoni smad1 5 8 and 0.0018 0.0014 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0077 0.1111
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0022 0.0075
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0029 0.0581
Brugia malayi PWWP domain containing protein 0.0009 0.0002 0.0003
Brugia malayi Telomerase reverse transcriptase 0.5065 0.7266 1
Trypanosoma brucei exonuclease, putative 0.0011 0.0005 0.0012
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1903 0.2723 1
Echinococcus multilocularis Smad4 0.0018 0.0014 0.0202
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0002 0.0002
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0016 0.0051
Toxoplasma gondii DNA methyltransferase 2, putative 0.0024 0.0023 0.0076
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0059 0.1138
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0006 0.0088
Schistosoma mansoni glutaminase 0.0327 0.0458 0.6629
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0008
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0014 0.0202
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0029 0.0581
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0077 0.1111
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0046
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0361 0.0507 0.1858
Echinococcus granulosus PWWP domain containing protein 2A 0.0009 0.0002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.1808
Echinococcus multilocularis flap endonuclease GEN 1 0.0011 0.0005 0.0075
Loa Loa (eye worm) RecQ helicase 0.0044 0.0052 0.1001
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0022 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.019 0.0262 1
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.0133 0.048
Schistosoma mansoni cpg binding protein 0.0076 0.0098 0.1423
Brugia malayi Muscleblind-like protein 0.0179 0.0245 0.0338
Brugia malayi hypothetical protein 0.0078 0.0101 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0133 0.048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0008
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0012 0.0007 0.0094
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.0094 1
Brugia malayi hypothetical protein 0.001 0.0002 0.0003
Brugia malayi XPG I-region family protein 0.0011 0.0005 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0154
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0021 0.0029
Echinococcus granulosus peregrin 0.0011 0.0005 0.0072
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0031 0.0107
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0021 0.0068
Echinococcus granulosus GPCR family 2 0.0015 0.0011 0.0154
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0016 0.0051
Echinococcus granulosus dna polymerase kappa 0.01 0.0133 0.1919
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0011 0.0005 0.0066
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0022 0.0072
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0125
Leishmania major importin beta-1 subunit, putative 0.0028 0.0029 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0126
Loa Loa (eye worm) serotonin transporter b 0.0073 0.0094 0.1808
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0087 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0489 0.0691 1
Entamoeba histolytica hypothetical protein 0.0214 0.0296 0.276
Mycobacterium tuberculosis Conserved hypothetical protein 0.0074 0.0096 0.3244
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0088
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.006
Schistosoma mansoni hepatoma derived growth factor 0.0009 0.0002 0.0028
Schistosoma mansoni hypothetical protein 0.0078 0.0101 0.1455
Echinococcus multilocularis flap endonuclease 1 0.0056 0.007 0.1008
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0024 0.0023 0.0074
Entamoeba histolytica hypothetical protein 0.0028 0.0029 0.0256
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0021 0.007
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0002 0.0002
Loa Loa (eye worm) Smad1 0.0018 0.0014 0.027
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0028
Leishmania major modification methylase-like protein 0.0024 0.0023 0.0076
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0057 0.0204
Echinococcus granulosus DNA methyltransferase 2, putative 0.0024 0.0023 0.0327
Echinococcus granulosus disco interacting protein 2 0.0046 0.0055 0.0794
Schistosoma mansoni DNA helicase recq1 0.0018 0.0015 0.0213
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0062 0.0219
Schistosoma mansoni DNA ligase IV 0.001 0.0002 0.0035
Plasmodium falciparum telomerase reverse transcriptase 0.1903 0.2723 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.01
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0012 0.0007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0038
Plasmodium vivax flap endonuclease 1, putative 0.0056 0.007 0.0251
Echinococcus multilocularis smad 0.0018 0.0014 0.0202
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0016 0.0229
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0078 0.0278
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0024 0.0023 0.0327
Giardia lamblia Telomerase catalytic subunit 0.1903 0.2723 1
Brugia malayi hypothetical protein 0.0009 0.0002 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0074 0.0096 0.1847
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0016 0.0051
Schistosoma mansoni DNA helicase recq5 0.0018 0.0015 0.0213
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0077 0.0106
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0133 0.048
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0012 0.0007 0.0094
Entamoeba histolytica hypothetical protein 0.0009 0.0002 0.0004
Toxoplasma gondii RNA-directed DNA polymerase 0.1903 0.2723 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0016 0.0306
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0011 0.0015
Schistosoma mansoni DNA polymerase eta 0.0099 0.0131 0.1897
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0006 0.0088
Brugia malayi SET domain containing protein 0.0009 0.0002 0.0002
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0015 0.0213
Toxoplasma gondii hypothetical protein 0.0058 0.0072 0.0259
Loa Loa (eye worm) transcription factor SMAD2 0.0258 0.036 0.6955
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0002 0.0002
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0012 0.0007 0.0094
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0002 0.0036
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0015 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0006 0.0088
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0005 0.0106
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0022 0.0073
Schistosoma mansoni SET domain protein 0.0013 0.0007 0.0106
Plasmodium vivax DEAD/DEAH helicase, putative 0.0012 0.0007 0.0019
Toxoplasma gondii hypothetical protein 0.0101 0.0134 0.0485
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0125
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0024 0.0023 0.0076
Giardia lamblia DNA damage repair protein 0.0023 0.0022 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0133 0.048
Brugia malayi hypothetical protein 0.0009 0.0002 0.0003
Schistosoma mansoni cpg binding protein 0.0074 0.0096 0.1383
Schistosoma mansoni ap endonuclease 0.0022 0.0021 0.0304
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0014 0.0009 0.0125
Onchocerca volvulus 0.0012 0.0006 0.0006
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0032 0.0035 0.0512
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0016 0.0229
Echinococcus granulosus flap endonuclease GEN 1 0.0011 0.0005 0.0075
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0024 0.0023 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0059 0.0209
Brugia malayi ImpB/MucB/SamB family protein 0.0074 0.0096 0.0132
Echinococcus granulosus Chromo domain 0.0014 0.0009 0.0125
Trypanosoma brucei unspecified product 0.0051 0.0062 0.0222
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0361 0.0507 0.1858
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0012
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0006 0.0088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0021 0.0304
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0057 0.0204
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0022 0.0073
Brugia malayi hypothetical protein 0.0016 0.0011 0.0016
Leishmania major hypothetical protein, conserved 0.0024 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0046
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0088
Schistosoma mansoni hypothetical protein 0.0203 0.028 0.4047
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0011 0.0005 0.0075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0021 0.0304
Trichomonas vaginalis exonuclease%2C+putative 0.0011 0.0005 0.006
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0056 0.007 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0008
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0074 0.0096 0.1384
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0016 0.0053
Leishmania major DNA polymerase kappa, putative 0.0023 0.0022 0.0073
Trichomonas vaginalis glutaminase, putative 0.0327 0.0458 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.0245 0.474
Entamoeba histolytica hypothetical protein 0.0078 0.0101 0.0928
Brugia malayi hypothetical protein 0.001 0.0002 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0016 0.0229
Echinococcus multilocularis cpg binding protein 0.0076 0.0098 0.1423
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0007 0.0017
Plasmodium falciparum transporter, putative 0.0012 0.0007 0.0015
Plasmodium vivax telomerase reverse transcriptase, putative 0.1903 0.2723 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0006 0.0088
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0024 0.0023 0.0198
Echinococcus granulosus hepatoma derived growth factor protein 0.0009 0.0002 0.0028
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0021 0.2077
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0052 0.0071
Echinococcus granulosus tar DNA binding protein 0.0061 0.0077 0.1111
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0005 0.0012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0088
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0154
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0046
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0002 0.0035
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0154
Entamoeba histolytica Flap nuclease, putative 0.0056 0.007 0.0638
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0012 0.0007 0.0017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0074 0.0096 0.1384
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0016 0.0229
Brugia malayi nuclear receptor NHR-88 0.0012 0.0006 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0006 0.0088
Loa Loa (eye worm) flap endonuclease-1 0.0056 0.007 0.1346
Echinococcus multilocularis serotonin transporter 0.0073 0.0094 0.1354
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0021 0.0408
Brugia malayi BRM protein 0.008 0.0104 0.0143
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0285
Echinococcus granulosus exonuclease 1 0.0011 0.0005 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0126
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0171 0.0234 0.0854
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0006 0.0008
Echinococcus multilocularis disco interacting protein 2 0.0046 0.0055 0.0794
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0005 0.0007
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0012 0.0007 0.0094
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0012 0.0007 0.0009
Plasmodium vivax amine transporter, putative 0.0012 0.0007 0.0019
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0012 0.0007 0.0094
Schistosoma mansoni Smad4 0.0018 0.0014 0.0202
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.0166
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0088
Treponema pallidum DNA ligase (lig) 0.001 0.0002 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0101 0.1455
Echinococcus multilocularis BRK domain 0.0014 0.0009 0.0125
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0014 0.0202
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0002 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0024 0.0079
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0154
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0002 0.0003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0021 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0117
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0002 0.5
Echinococcus multilocularis Chromo domain 0.0014 0.0009 0.0125
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0046
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0015 0.0045
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0008
Brugia malayi polk-prov protein 0.0049 0.0059 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0024 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0005 0.0012
Trichomonas vaginalis lymphoid specific helicase, putative 0.0015 0.001 0.016
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0015 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0046
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0022 0.0075
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0006 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.01
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0002 0.0009
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0028
Trichomonas vaginalis flap endonuclease-1, putative 0.0056 0.007 0.1476
Echinococcus granulosus bloom syndrome protein 0.0044 0.0052 0.0749
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0052 0.0749
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0004
Onchocerca volvulus 0.0009 0.0002 0.0002
Echinococcus granulosus smad 0.0018 0.0014 0.0202
Echinococcus granulosus snurportin 1 0.0368 0.0517 0.7485
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0088
Echinococcus granulosus flap endonuclease 1 0.0056 0.007 0.1008
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0015 0.0285
Schistosoma mansoni smad1 5 8 and 0.0018 0.0014 0.0202
Schistosoma mansoni topbp1 0.001 0.0002 0.0035
Plasmodium falciparum exonuclease I, putative 0.0011 0.0005 0.001
Echinococcus multilocularis hepatoma derived growth factor protein 0.0009 0.0002 0.0028
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0012 0.0007 0.0094
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0154
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.0008
Echinococcus multilocularis peregrin 0.0011 0.0005 0.0072
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0052
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0002 0.0029
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0012 0.0007 0.0094
Schistosoma mansoni hypothetical protein 0.0203 0.028 0.4047
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0088
Echinococcus granulosus importin subunit beta 1 0.0034 0.0038 0.0553
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0125
Schistosoma mansoni sodium/chloride dependent transporter 0.0012 0.0007 0.0094
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0022 0.0073
Mycobacterium ulcerans hypothetical protein 0.0023 0.0022 0.0428
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0021 0.0408
Brugia malayi Smad1 0.0018 0.0014 0.0019
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0022 0.0317
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0171 0.0234 0.0854
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0021 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0016 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0117
Brugia malayi nuclear hormone receptor 0.0012 0.0006 0.0008
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0074 0.0096 0.1849
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0002 0.0036
Brugia malayi TAR-binding protein 0.0061 0.0077 0.0106
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.1808
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0024 0.0023 0.0327
Onchocerca volvulus 0.0012 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0007 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0008
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0014 0.0202
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0005 0.0079
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0009 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0117
Plasmodium vivax exonuclease I, putative 0.0011 0.0005 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0058 0.008
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0012 0.0007 0.0094
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0044 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0022 0.0073
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0056 0.007 0.0249
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0062 0.0219
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0014 0.0202
Plasmodium falciparum flap endonuclease 1 0.0056 0.007 0.0247
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0117
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0005 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0011 0.0015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0036
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0125
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0015 0.0213
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0002 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.01 0.0133 0.2858
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0012 0.0007 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0077 0.1111
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0006 0.0088
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.006
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0015 0.001 0.0029
Brugia malayi glutaminase DH11.1 0.0327 0.0458 0.0631
Echinococcus granulosus Smad4 0.0018 0.0014 0.0202
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0031 0.0106
Schistosoma mansoni sodium-dependent amino acid transporter 0.0012 0.0007 0.0094
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0752 0.107 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0081 0.0105 0.0378
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0022 0.0075
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0094 0.1354
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0021 0.0183
Echinococcus granulosus nibrin 0.001 0.0002 0.0035
Echinococcus multilocularis muscleblind protein 1 0.0179 0.0245 0.3548
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0095 0.1372

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.4 nM In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake site ChEMBL. 16250644
Ki (binding) = 1.4 nM In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake site ChEMBL. 16250644
Ki (binding) = 24 nM In vitro inhibitory constant against [3H]-spiperone binding to human dopamine D2 receptor expressed in CHO cells ChEMBL. 16250644
Ki (binding) = 24 nM In vitro inhibitory constant against [3H]-spiperone binding to human dopamine D2 receptor expressed in CHO cells ChEMBL. 16250644

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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