Detailed information for compound 373580

Basic information

Technical information
  • TDR Targets ID: 373580
  • Name: propan-2-yl N-[3-[4-(imidazol-1-ylmethyl)phen yl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylc arbamate
  • MW: 461.597 | Formula: C22H27N3O4S2
  • H donors: 1 H acceptors: 4 LogP: 4.82 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cc1cc(c(s1)S(=O)(=O)NC(=O)OC(C)C)c1ccc(cc1)Cn1cncc1)C
  • InChi: 1S/C22H27N3O4S2/c1-15(2)11-19-12-20(21(30-19)31(27,28)24-22(26)29-16(3)4)18-7-5-17(6-8-18)13-25-10-9-23-14-25/h5-10,12,14-16H,11,13H2,1-4H3,(H,24,26)
  • InChiKey: LIBZHQJJLOPSQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isopropyl N-[[3-[4-(imidazol-1-ylmethyl)phenyl]-5-isobutyl-2-thienyl]sulfonyl]carbamate
  • N-[[3-[4-(1-imidazolylmethyl)phenyl]-5-isobutyl-2-thienyl]sulfonyl]carbamic acid isopropyl ester
  • N-[[3-[4-(imidazol-1-ylmethyl)phenyl]-5-isobutyl-2-thienyl]sulfonyl]carbamic acid isopropyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens angiotensin II receptor, type 2 Starlite/ChEMBL References
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II type 2 (AT-2) receptor   363 aa 364 aa 20.9 %
Echinococcus granulosus allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 340 aa 24.1 %
Schistosoma mansoni adenoreceptor Angiotensin II type 2 (AT-2) receptor   363 aa 328 aa 22.0 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 305 aa 21.6 %
Echinococcus granulosus neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.2 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor angiotensin II receptor, type 2 363 aa 398 aa 18.3 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.1 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.5 %
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II type 2 (AT-2) receptor   363 aa 356 aa 23.3 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 22.1 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.8 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II type 2 (AT-2) receptor   363 aa 310 aa 23.5 %
Echinococcus multilocularis allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 342 aa 24.6 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 311 aa 23.8 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.3 %
Schistosoma japonicum Rhodopsin, putative Angiotensin II type 2 (AT-2) receptor   363 aa 341 aa 22.0 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis RNA directed DNA polymerase 0.0011 0.0023 0.0041
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0015 0.0084 0.0089
Schistosoma mansoni tsg101-related 0.0052 0.0686 0.0877
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0015 0.0084 0.0355
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0015 0.0084 0.0062
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.4566 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2058 0.2631
Loa Loa (eye worm) transcription factor SMAD2 0.0276 0.4296 0.757
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0037 0.0441 0.0778
Brugia malayi reverse transcriptase 0.0011 0.0023 0.005
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0441 0.0778
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0015 0.0084 0.0164
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Brugia malayi Cell death protein 3 precursor 0.0097 0.1411 0.3049
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0015 0.0084 0.0355
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0142 0.0648
Schistosoma mansoni hypothetical protein 0.0047 0.0602 0.077
Mycobacterium ulcerans aldehyde dehydrogenase 0.0272 0.4243 0.4194
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Echinococcus granulosus oncosphere protein Tso22e 0.0146 0.2205 0.3885
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0244 0.0487
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Trichomonas vaginalis cyclin D, putative 0.0017 0.0119 0.0212
Echinococcus multilocularis cyclins 0.0017 0.0119 0.021
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0033 0.0383 0.0675
Trichomonas vaginalis cyclin B, putative 0.0017 0.0119 0.0212
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0713 1
Schistosoma mansoni hypothetical protein 0.0102 0.1484 0.1898
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0654 0.139
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0023 0.0041
Echinococcus multilocularis cyclins 0.0017 0.0119 0.021
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0142 0.0299
Schistosoma mansoni phosphoglucomutase 0.0132 0.197 0.2519
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0095 0.1377 0.1746
Schistosoma mansoni ran 0.0025 0.0244 0.0312
Plasmodium vivax hypothetical protein, conserved 0.005 0.0654 0.9157
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1535 0.3328
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0361 0.5675 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Echinococcus granulosus cyclins 0.0017 0.0119 0.021
Trypanosoma brucei RNA helicase, putative 0.0494 0.782 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0654 0.139
Entamoeba histolytica cyclin family protein 0.0017 0.0119 0.0154
Toxoplasma gondii aldehyde dehydrogenase 0.0272 0.4243 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0119 0.021
Schistosoma mansoni protein phosphatase 2C 0.0011 0.0015 0.0019
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0015 0.0084 0.0355
Schistosoma mansoni smad1 5 8 and 0.0019 0.0146 0.0186
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0015 0.0027
Trypanosoma brucei unspecified product 0.0143 0.2151 0.2736
Loa Loa (eye worm) hypothetical protein 0.0028 0.0301 0.0531
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.1703 0.2177
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0033 0.0383 0.0675
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0146 0.0257
Onchocerca volvulus 0.0011 0.0023 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0023 0.0041
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0244 0.1173
Echinococcus multilocularis lamin dm0 0.0029 0.031 0.0546
Trypanosoma brucei ingi protein (ORF1) 0.0143 0.2151 0.2736
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0015 0.0084 0.0355
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0441 0.0778
Brugia malayi Troponin I 0.0118 0.1747 0.3775
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.2058 0.3626
Echinococcus multilocularis cyclins 0.0017 0.0119 0.021
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.4566 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0441 0.0778
Loa Loa (eye worm) troponin I 0.0118 0.1747 0.3078
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Brugia malayi jmjC domain containing protein 0.0011 0.0015 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.4566 1
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0077 0.1082 0.1907
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.031 0.067
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0023 0.0041
Echinococcus granulosus lamin 0.0029 0.031 0.0546
Trichomonas vaginalis cyclins, putative 0.0017 0.0119 0.0212
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0015 0.0084 0.0108
Schistosoma mansoni importin beta-1 0.0034 0.0389 0.0497
Toxoplasma gondii hypothetical protein 0.0013 0.0052 0.0088
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0015 0.0027
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0244 0.0528
Schistosoma mansoni cyclins 0.0017 0.0119 0.0152
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0146 0.0257
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.005 0.0654 0.0837
Echinococcus granulosus phd:f box containing protein 0.0011 0.0015 0.0027
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0015 0.0084 0.0164
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0119 0.0258
Echinococcus granulosus snurportin 1 0.0361 0.5675 1
Echinococcus multilocularis caspase 0.0133 0.1989 0.3506
Entamoeba histolytica cyclin, putative 0.0017 0.0119 0.0154
Echinococcus multilocularis GPCR, family 2 0.0047 0.0602 0.1062
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0015 0.0084 0.0062
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0015 0.0084 0.0355
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1535 0.3328
Echinococcus granulosus KRAB A domain containing protein 0.0011 0.0023 0.0041
Echinococcus multilocularis muscleblind protein 1 0.0296 0.4627 0.8153
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0015 0.0084 0.0355
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0015 0.0084 0.0164
Brugia malayi Protein kinase domain containing protein 0.0095 0.1377 0.2977
Echinococcus multilocularis cyclins 0.0017 0.0119 0.021
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1484 0.3209
Trypanosoma brucei ingi protein (ORF1) 0.0143 0.2151 0.2736
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.215 0.2083
Schistosoma mansoni hypothetical protein 0.0033 0.0377 0.0483
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0015 0.0084 0.0164
Entamoeba histolytica hypothetical protein 0.0095 0.1377 0.294
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0015 0.0084 0.0077
Loa Loa (eye worm) hypothetical protein 0.0094 0.1364 0.2404
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0244 0.3285
Leishmania major aldehyde dehydrogenase, putative 0.0015 0.0084 0.0164
Leishmania major importin beta-1 subunit, putative 0.0027 0.0285 0.0639
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0011 0.0023 0.0029
Echinococcus multilocularis Smad4 0.0019 0.0146 0.0257
Onchocerca volvulus 0.0029 0.031 0.1221
Echinococcus multilocularis tar DNA binding protein 0.0137 0.2058 0.3626
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0587 0.1035
Echinococcus granulosus intermediate filament protein 0.0029 0.031 0.0546
Echinococcus granulosus muscleblind protein 0.0296 0.4627 0.8153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.4566 1
Onchocerca volvulus Ribonuclease H1 homolog 0.0132 0.197 0.7765
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2058 0.2631
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0389 0.0479
Entamoeba histolytica hypothetical protein 0.0115 0.1703 0.3661
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0377 0.0665
Brugia malayi hypothetical protein 0.0054 0.0713 0.1541
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0285 0.0577
Brugia malayi RNase H family protein 0.0132 0.197 0.4258
Schistosoma mansoni hypothetical protein 0.0199 0.3053 0.3904
Echinococcus multilocularis ribonuclease H1 0.0132 0.197 0.3471
Echinococcus multilocularis caspase 2 0.0097 0.1411 0.2486
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0077 0.1082 0.1907
Echinococcus granulosus cyclin b3 0.0017 0.0119 0.021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0599 0.1055
Entamoeba histolytica hypothetical protein 0.0115 0.1703 0.3661
Loa Loa (eye worm) hypothetical protein 0.0034 0.0389 0.0685
Entamoeba histolytica protein kinase domain containing protein 0.0095 0.1377 0.294
Brugia malayi Aldehyde dehydrogenase protein 4 0.0015 0.0084 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0947 0.1669
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.007 0.0972 0.3831
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0441 0.0778
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0654 0.139
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0654 0.139
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.1703 0.3001
Echinococcus multilocularis peregrin 0.0033 0.0377 0.0665
Echinococcus multilocularis tyrosine protein kinase Srms 0.0033 0.0383 0.0675
Brugia malayi jmjC domain containing protein 0.0011 0.0015 0.0033
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.1535 0.2704
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0015 0.0084 0.0149
Loa Loa (eye worm) hypothetical protein 0.0047 0.0602 0.1062
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Schistosoma mansoni troponin I 0.0118 0.1747 0.2233
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0023 0.0041
Echinococcus multilocularis caspase 3 0.0083 0.1177 0.2075
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0133 0.1989 0.3506
Entamoeba histolytica protein kinase, putative 0.0095 0.1377 0.294
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0654 0.139
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0285 0.1383
Trypanosoma cruzi CYC2-like cyclin, putative 0.0017 0.0119 0.0533
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.1703 0.3001
Brugia malayi Troponin T 0.007 0.0972 0.2101
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0015 0.0084 0.0149
Schistosoma mansoni hypothetical protein 0.0199 0.3053 0.3904
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2058 0.2631
Echinococcus granulosus caspase 2 0.0097 0.1411 0.2486
Plasmodium vivax importin-beta 2, putative 0.0034 0.0389 0.5351
Loa Loa (eye worm) RNA binding protein 0.0137 0.2058 0.3626
Echinococcus granulosus caspase 8 0.005 0.0654 0.1153
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0654 0.139
Echinococcus granulosus cyclin B3 1 0.0017 0.0119 0.021
Brugia malayi RNase H family protein 0.0132 0.197 0.4258
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0015 0.0027
Schistosoma mansoni phosphoglucomutase 0.0132 0.197 0.2519
Brugia malayi Muscleblind-like protein 0.0296 0.4627 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.4566 1
Schistosoma mansoni caspase-7 (C14 family) 0.0133 0.1989 0.2544
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Schistosoma mansoni jumonji domain containing protein 0.0086 0.1235 0.1579
Brugia malayi jmjC domain containing protein 0.0109 0.1595 0.3448
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0654 0.139
Echinococcus multilocularis geminin 0.0199 0.3053 0.538
Trypanosoma brucei Metacaspase-4 0.005 0.0654 0.0819
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0441 0.0778
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0015 0.0084 0.0149
Brugia malayi Troponin T 0.007 0.0972 0.2101
Brugia malayi SRC-1 0.0037 0.0441 0.0954
Mycobacterium ulcerans aldehyde dehydrogenase 0.0272 0.4243 0.4194
Schistosoma mansoni troponin I 0.0118 0.1747 0.2233
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0244 0.0431
Trypanosoma brucei polo-like protein kinase 0.0105 0.1535 0.1947
Giardia lamblia PHD finger protein 15 0.0033 0.0377 0.078
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0142 0.1813
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0629 1 1
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0015 0.0084 0.0062
Echinococcus granulosus caspase 0.0133 0.1989 0.3506
Schistosoma mansoni cyclin B3 0.0017 0.0119 0.0152
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0017 0.0003
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0142 0.0299
Schistosoma mansoni tsg101-related 0.0064 0.0875 0.1119
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.2245 0.4851
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0285 0.0577
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0015 0.0084 0.0164
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Schistosoma mansoni hypothetical protein 0.0047 0.0602 0.077
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0037 0.0441 0.0778
Echinococcus multilocularis troponin i 0.0118 0.1747 0.3078
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0036 0.0047
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.4566 1
Trichomonas vaginalis cyclin B, putative 0.0017 0.0119 0.0212
Loa Loa (eye worm) hypothetical protein 0.0102 0.1484 0.2616
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0025 0.0239 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0654 0.139
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0244 0.0294
Loa Loa (eye worm) hypothetical protein 0.0033 0.0377 0.0665
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0017 0.0119 0.0246
Loa Loa (eye worm) nuclear factor I 0.001 0.001 0.0018
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.1535 0.2704
Leishmania major metacaspase, putative 0.005 0.0654 0.1512
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0068 0.012
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.049 0.0627
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0654 0.139
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0093 0.0163
Loa Loa (eye worm) hypothetical protein 0.0057 0.076 0.1339
Schistosoma mansoni hypothetical protein 0.0361 0.5675 0.7256
Plasmodium falciparum metacaspase-like protein 0.005 0.0654 0.9157
Schistosoma mansoni hypothetical protein 0.0047 0.0602 0.077
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0084 0.0108
Brugia malayi MH2 domain containing protein 0.0276 0.4296 0.9285
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Brugia malayi AF-10 protein 0.0011 0.0017 0.0037
Brugia malayi Bromodomain containing protein 0.0033 0.0377 0.0816
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0015 0.0084 0.0089
Brugia malayi hypothetical protein 0.0011 0.0023 0.005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0149
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0015 0.0084 0.0062
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0015 0.0084 0.0149
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0084 0.0108
Brugia malayi aldehyde dehydrogenase 0.0015 0.0084 0.0183
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0015 0.0084 0.0149
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0654 0.139
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0015 0.0084 0.0149
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0441 0.0778
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.005 0.0177
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0713 0.0894
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0233 0.041
Leishmania major GTP-binding protein, putative 0.0025 0.0244 0.0542
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0037 0.0441 0.0778
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.049 0.0864
Leishmania major hypothetical protein, conserved 0.0025 0.0239 0.0529
Brugia malayi Zinc knuckle family protein 0.0011 0.0023 0.005
Brugia malayi intermediate filament protein 0.0029 0.031 0.067
Entamoeba histolytica protein kinase, putative 0.003 0.0323 0.0605
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1535 0.3328
Giardia lamblia Ribonuclease H 0.0132 0.197 0.4286
Loa Loa (eye worm) hypothetical protein 0.0118 0.1747 0.3078
Trypanosoma cruzi ribonuclease H1, putative 0.0132 0.197 1
Schistosoma mansoni smad 0.0019 0.0146 0.0186
Schistosoma mansoni aldehyde dehydrogenase 0.0272 0.4243 0.5425
Loa Loa (eye worm) hypothetical protein 0.0167 0.2537 0.4471
Schistosoma mansoni hypothetical protein 0.0015 0.0084 0.0108
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0377 0.0857
Giardia lamblia G2/mitotic-specific cyclin B 0.0017 0.0119 0.0212
Trypanosoma brucei metacaspase MCA2 0.005 0.0654 0.0819
Brugia malayi PHD-finger family protein 0.0011 0.0017 0.0037
Giardia lamblia Cyclin A 0.0017 0.0119 0.0212
Trichomonas vaginalis ran, putative 0.0025 0.0244 0.0487
Schistosoma mansoni hypothetical protein 0.0024 0.0233 0.0298
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Loa Loa (eye worm) TAR-binding protein 0.0137 0.2058 0.3626
Brugia malayi MH2 domain containing protein 0.0019 0.0146 0.0315
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0029
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0084 0.0355
Onchocerca volvulus 0.0011 0.0023 0.0091
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.049 0.0627
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0602 0.1062
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0244 0.3285
Loa Loa (eye worm) hypothetical protein 0.0149 0.2245 0.3955
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.003
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0629 1 1
Brugia malayi TAR-binding protein 0.0137 0.2058 0.4447
Brugia malayi hypothetical protein 0.0011 0.0023 0.005
Giardia lamblia Hypothetical protein 0.0017 0.0119 0.0212
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0142 0.1813
Loa Loa (eye worm) Smad1 0.0019 0.0146 0.0257
Echinococcus multilocularis phd:f box containing protein 0.0011 0.0015 0.0027
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0011 0.0023 0.0041
Loa Loa (eye worm) troponin 0.007 0.0972 0.1713
Plasmodium vivax metacaspase 1, putative 0.005 0.0654 0.9157
Echinococcus multilocularis musashi 0.0029 0.031 0.0546
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.005 0.0654 0.1414
Echinococcus multilocularis muscleblind protein 0.0296 0.4627 0.8153
Echinococcus granulosus smad 0.0019 0.0146 0.0257
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0023 0.0041
Schistosoma mansoni tyrosine kinase 0.0037 0.0441 0.0564
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0015 0.0084 0.0077
Onchocerca volvulus 0.0047 0.0599 0.2359
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0119 0.0212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.4566 1
Brugia malayi Troponin family protein 0.0118 0.1747 0.3775
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0602 0.1062
Onchocerca volvulus 0.0167 0.2537 1
Echinococcus multilocularis cyclin b3 0.0017 0.0119 0.021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.4566 1
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0015 0.0084 0.0089
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0015 0.0084 0.0062
Schistosoma mansoni troponin I 0.0118 0.1747 0.2233
Entamoeba histolytica hypothetical protein 0.0115 0.1703 0.3661
Loa Loa (eye worm) TK protein kinase 0.003 0.0323 0.0569
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0244 0.1173
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.0015 0.0027
Loa Loa (eye worm) SRC-1 0.0037 0.0441 0.0778
Brugia malayi protein-tyrosine kinase 0.0033 0.0383 0.0828
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0133 0.1989 0.3506
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0602 0.1062
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0084 0.0355
Echinococcus multilocularis dual specificity 0.0095 0.1377 0.2427
Brugia malayi jmjC domain containing protein 0.004 0.049 0.1059
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0654 0.1512
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.4566 1
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.2058 0.4447
Echinococcus granulosus cyclins 0.0017 0.0119 0.021
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1535 0.7774
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.005 0.0059
Loa Loa (eye worm) cyclin domain-containing protein 0.0017 0.0119 0.021
Echinococcus multilocularis cyclin B3 1 0.0017 0.0119 0.021
Brugia malayi hypothetical protein 0.0167 0.2537 0.5483
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0377 0.5191
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0015 0.0084 0.0108
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.1535 0.6049
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.1411 0.1804
Schistosoma mansoni hypothetical protein 0.0047 0.0599 0.0765
Trypanosoma brucei hypothetical protein, conserved 0.0143 0.2151 0.2736
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0017 0.0119 0.021
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0023 0.0041
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0142 0.0306
Brugia malayi jmjC domain containing protein 0.0011 0.0015 0.0033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0285 0.0577
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2058 0.2631
Trypanosoma brucei metacaspase 0.005 0.0654 0.0819
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0602 0.1302
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0017 0.0005
Brugia malayi hypothetical protein 0.0047 0.0599 0.1294
Onchocerca volvulus Cell death protein 3 homolog 0.0097 0.1411 0.556
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0015 0.0027
Trypanosoma brucei mitotic cyclin 6 0.0017 0.0119 0.0133
Brugia malayi Smad1 0.0019 0.0146 0.0315
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0015 0.0084 0.0089
Echinococcus multilocularis cyclins 0.0017 0.0119 0.021
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1535 0.7774
Loa Loa (eye worm) hypothetical protein 0.0029 0.031 0.0546
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0366 0.0645
Loa Loa (eye worm) hypothetical protein 0.0296 0.4627 0.8153
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0017 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.005 0.0177
Onchocerca volvulus 0.0029 0.031 0.1221
Schistosoma mansoni ran 0.0025 0.0244 0.0312
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0654 0.139
Brugia malayi hypothetical protein 0.0035 0.0405 0.0874
Leishmania major cyclin 0.0017 0.0119 0.0246
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0015 0.0084 0.0164
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0015 0.0084 0.0149
Echinococcus multilocularis cyclins 0.0017 0.0119 0.021
Brugia malayi jmjC domain containing protein 0.0011 0.0015 0.0033
Brugia malayi RNA, U transporter 1 0.0096 0.1396 0.3017
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0455 0.0801
Echinococcus granulosus apoptotic protease activating factor 1 0.0047 0.0599 0.1055
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.4566 1
Schistosoma mansoni phd/f-box containing protein 0.0011 0.0015 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.005 0.0059
Leishmania major aldehyde dehydrogenase, putative 0.0015 0.0084 0.0164
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0052 0.0686 0.1409
Schistosoma mansoni protein kinase 0.0011 0.0023 0.0029
Schistosoma mansoni hypothetical protein 0.0118 0.1747 0.2233
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0684 0.1455
Trypanosoma cruzi cyclin 6, putative 0.0017 0.0119 0.0533
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0023 0.0041
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.1535 0.3594
Brugia malayi hypothetical protein 0.007 0.0972 0.2101
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0095 0.1377 0.2427
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.031 0.0546
Echinococcus granulosus GPCR family 2 0.0047 0.0602 0.1062
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0017 0.0037
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0233 0.041
Brugia malayi Importin beta-1 subunit 0.0034 0.0389 0.084
Schistosoma mansoni lamin 0.0029 0.031 0.0396
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0272 0.4243 0.7477
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0389 0.0479
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0015 0.0084 0.0077
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0011 0.0023 0.0091
Schistosoma mansoni Smad4 0.0019 0.0146 0.0186
Schistosoma mansoni aldehyde dehydrogenase 0.0272 0.4243 0.5425
Onchocerca volvulus 0.0017 0.0119 0.047
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.1377 0.697
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0095 0.1377 0.3223
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.0832 0.1467
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0059 0.0105
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0366 0.0645
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0068 0.012
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0323 0.0569
Loa Loa (eye worm) hypothetical protein 0.007 0.0972 0.1713
Echinococcus multilocularis apoptotic protease activating factor 1 0.0047 0.0599 0.1055
Entamoeba histolytica hypothetical protein 0.0115 0.1703 0.3661
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0142 0.0648
Echinococcus multilocularis tyrosine protein kinase Blk 0.0033 0.0383 0.0675
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0146 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0684 0.1455
Trypanosoma cruzi metacaspase, putative 0.005 0.0654 0.327
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Echinococcus granulosus importin subunit beta 1 0.0034 0.0389 0.0685
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0146 0.0257
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Brugia malayi MH1 domain containing protein 0.0019 0.0146 0.0315
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0377 0.0665
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0142 0.025
Schistosoma mansoni lamin 0.0029 0.031 0.0396
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0023 0.0041
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Brugia malayi reverse transcriptase 0.0011 0.0023 0.005
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0142 0.0181
Treponema pallidum ribonuclease H (rnhA) 0.0132 0.197 0.4207
Trypanosoma brucei ribonuclease H1 0.0132 0.197 0.2504
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0713 1
Echinococcus multilocularis smad 0.0019 0.0146 0.0257
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.1535 0.3288
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0029
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0142 0.0299
Onchocerca volvulus Alhambra homolog 0.0033 0.0377 0.1488
Brugia malayi Zinc knuckle family protein 0.0011 0.0023 0.005
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0094 0.1364 0.2404
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0015 0.0084 0.0149
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.1377 0.697
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0037 0.0441 0.0778
Trichomonas vaginalis cyclin B, putative 0.0017 0.0119 0.0212
Loa Loa (eye worm) MH2 domain-containing protein 0.0276 0.4296 0.757
Echinococcus granulosus RNA directed DNA polymerase 0.0011 0.0023 0.0041
Schistosoma mansoni caspase-3 (C14 family) 0.0133 0.1989 0.2544
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.049 0.0864
Trichomonas vaginalis cyclin A, putative 0.0017 0.0119 0.0212
Brugia malayi hypothetical protein 0.0011 0.0023 0.005
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0142 0.0119
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.1595 0.2811
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0272 0.4243 0.7477
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0146 0.2205 0.3885
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1535 0.3328
Loa Loa (eye worm) hypothetical protein 0.0118 0.1747 0.3078
Mycobacterium ulcerans aldehyde dehydrogenase 0.0272 0.4243 0.4194
Loa Loa (eye worm) hypothetical protein 0.0013 0.0059 0.0105
Brugia malayi hypothetical protein 0.0115 0.1703 0.368
Loa Loa (eye worm) hypothetical protein 0.005 0.0654 0.1153
Brugia malayi MH2 domain containing protein 0.0019 0.0146 0.0315
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0142 0.025
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0389 0.0685
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0132 0.197 1
Trichomonas vaginalis cyclin B, putative 0.0017 0.0119 0.0212
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0037 0.0441 0.0778
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0441 0.0778
Trypanosoma cruzi metacaspase, putative 0.005 0.0654 0.327
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0654 0.1512
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.012
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0377 0.0665
Echinococcus granulosus cyclins 0.0017 0.0119 0.021
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0146 0.2205 0.869
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0084 0.0355
Entamoeba histolytica Ran family GTPase 0.0025 0.0244 0.0431
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0177
Schistosoma mansoni tyrosine kinase 0.0037 0.0441 0.0564
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0602 0.1062
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0146 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0654 0.139
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0713 0.1651
Schistosoma mansoni smad1 5 8 and 0.0019 0.0146 0.0186
Echinococcus granulosus peregrin 0.0033 0.0377 0.0665
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1377 0.1761
Echinococcus granulosus cyclin B 0.0017 0.0119 0.021
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.0832 0.1781
Echinococcus granulosus Smad4 0.0019 0.0146 0.0257
Schistosoma mansoni jumonji domain containing protein 0.0011 0.0015 0.0019
Schistosoma mansoni intermediate filament proteins 0.0029 0.031 0.0396
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0654 0.139
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0119 0.0258
Trichomonas vaginalis cyclins, putative 0.0017 0.0119 0.0212
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0146 0.0257
Giardia lamblia Alcohol dehydrogenase 0.0015 0.0084 0.0135
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0015 0.0084 0.0149
Brugia malayi hypothetical protein 0.0077 0.1082 0.2339
Brugia malayi isocitrate dehydrogenase 0.0019 0.0142 0.0306
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0011 0.0023 0.001
Trichomonas vaginalis cyclins, putative 0.0017 0.0119 0.0212
Trichomonas vaginalis cyclin D, putative 0.0017 0.0119 0.0212
Trypanosoma cruzi metacaspase, putative 0.005 0.0654 0.327
Entamoeba histolytica cyclin, putative 0.0017 0.0119 0.0154
Trichomonas vaginalis cyclin B3, putative 0.0017 0.0119 0.0212
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.1535 0.3317
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2058 0.2631
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0654 0.327
Trypanosoma brucei metacaspase 5, putative 0.005 0.0654 0.0819
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0023 0.0041
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0654 0.1512
Brugia malayi MH1 domain containing protein 0.001 0.001 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0654 0.139
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0377 0.0857
Leishmania major ribonuclease H1, putative 0.0132 0.197 0.4624
Entamoeba histolytica hypothetical protein 0.0027 0.0285 0.0522
Entamoeba histolytica cyclin family protein 0.0017 0.0119 0.0154
Echinococcus granulosus caspase 3 0.0083 0.1177 0.2075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.4566 1
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.0832 0.1467
Echinococcus multilocularis cyclin B 0.0017 0.0119 0.021
Echinococcus granulosus ribonuclease H1 0.0132 0.197 0.3471
Brugia malayi Troponin T 0.007 0.0972 0.2101
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0017 0.0119 0.021
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0713 1
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0015 0.0084 0.0333
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0084 0.0108
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.0015 0.0027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0142 0.025
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0142 0.025
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.0015 0.0027
Loa Loa (eye worm) troponin T 0.007 0.0972 0.1713
Schistosoma mansoni tsg101-related 0.0064 0.0875 0.1119
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0015 0.0027
Loa Loa (eye worm) TK protein kinase 0.0033 0.0383 0.0675
Brugia malayi reverse transcriptase 0.0011 0.0023 0.005
Trypanosoma cruzi cyclin, putative 0.0017 0.0119 0.0533
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.4566 1
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0015 0.0084 0.0149
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0025 0.0239 0.1145
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0244 0.0431
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0142 0.0162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.2245 0.4851
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0011 0.0023 0.001
Entamoeba histolytica protein kinase, putative 0.0095 0.1377 0.294
Echinococcus multilocularis caspase 8 0.005 0.0654 0.1153
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1535 0.3328
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0015 0.0084 0.0135
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.0832 0.1467
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0142 0.025
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.1595 0.2811
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0017 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0146 0.0257
Plasmodium falciparum metacaspase 1 0.005 0.0654 0.9157
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0017 0.0003
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0015 0.0084 0.0183
Echinococcus granulosus troponin i 0.0118 0.1747 0.3078
Schistosoma mansoni hypothetical protein 0.0047 0.0602 0.077
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1535 0.3328
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0084 0.0108
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0654 0.327
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0602 0.1302
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.1535 0.2704
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.0015 0.0019
Trichomonas vaginalis cyclins, putative 0.0017 0.0119 0.0212
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0023 0.0041
Leishmania major hypothetical protein, conserved 0.0054 0.0713 0.1651
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0023 0.0041
Leishmania major aldehyde dehydrogenase, putative 0.0015 0.0084 0.0164
Echinococcus granulosus lamin dm0 0.0029 0.031 0.0546
Trichomonas vaginalis cyclin B, putative 0.0017 0.0119 0.0212
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0377 0.0483
Brugia malayi hypothetical protein 0.0011 0.0023 0.005
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.1257
Schistosoma mansoni troponin I 0.0118 0.1747 0.2233
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0037 0.0441 0.0778
Echinococcus granulosus geminin 0.0199 0.3053 0.538
Trypanosoma cruzi ribonuclease H1, putative 0.0132 0.197 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0015 0.0027
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0015 0.0084 0.0149
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0323 0.0569
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0119 0.0258
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0602 0.1062
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Giardia lamblia Kinase, PLK 0.0105 0.1535 0.3328
Trichomonas vaginalis hypothetical protein 0.0037 0.0446 0.0932
Loa Loa (eye worm) aldehyde dehydrogenase 0.0015 0.0084 0.0149
Trichomonas vaginalis cyclins, putative 0.0017 0.0119 0.0212
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0015 0.0084 0.0062
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0015 0.0084 0.0077
Schistosoma mansoni cyclin B 0.0017 0.0119 0.0152
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0015 0.0084 0.0089
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0142 0.025
Toxoplasma gondii ribonuclease HI protein 0.0132 0.197 0.4624
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0084 0.0108
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0023 0.0041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0142 0.025
Schistosoma mansoni phosphoglucomutase 0.0132 0.197 0.2519
Trypanosoma brucei metacaspase MCA3 0.005 0.0654 0.0819
Echinococcus multilocularis lamin 0.0029 0.031 0.0546
Echinococcus granulosus tyrosine kinase 0.0033 0.0383 0.0675
Trypanosoma cruzi metacaspase, putative 0.005 0.0654 0.327
Plasmodium falciparum importin beta, putative 0.0034 0.0389 0.5351
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0587 0.1035
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0037 0.0441 0.0778
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0272 0.4243 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.2245 0.3955
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.215 0.2083
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0011 0.0023 0.001
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.049 0.0864
Schistosoma mansoni hypothetical protein 0.0494 0.782 1
Schistosoma mansoni kinase 0.0053 0.0706 0.0903
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0272 0.4243 0.423
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0015 0.0084 0.0355
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0023 0.0041
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0015 0.0084 0.0183
Loa Loa (eye worm) hypothetical protein 0.0097 0.1411 0.2486
Loa Loa (eye worm) hypothetical protein 0.0296 0.4627 0.8153
Schistosoma mansoni smad1 5 8 and 0.0019 0.0146 0.0186
Plasmodium falciparum phd finger protein, putative 0.0033 0.0377 0.5191
Brugia malayi RNA binding protein 0.0137 0.2058 0.4447
Brugia malayi RNase H family protein 0.0132 0.197 0.4258
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0713 0.3571
Echinococcus granulosus cyclins 0.0017 0.0119 0.021
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0244 0.0431
Echinococcus granulosus cyclins 0.0017 0.0119 0.021
Brugia malayi MH1 domain containing protein 0.0019 0.0146 0.0315
Trypanosoma cruzi cyclin, putative 0.0017 0.0119 0.0533
Echinococcus multilocularis cyclins 0.0017 0.0119 0.021
Brugia malayi PHD-finger family protein 0.0033 0.0377 0.0816
Echinococcus granulosus tar DNA binding protein 0.0137 0.2058 0.3626
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0084 0.0355
Echinococcus granulosus tyrosine protein kinase Src64B 0.0037 0.0441 0.0778
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0018
Brugia malayi DnaJ domain containing protein 0.0061 0.0832 0.1799
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0713 0.3571
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0015 0.0084 0.0062
Trichomonas vaginalis ribonuclease H1, putative 0.0132 0.197 0.4286
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0654 0.139
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0015 0.0084 0.0062
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0142 0.0162
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0023 0.0041
Loa Loa (eye worm) intermediate filament protein 0.0029 0.031 0.0546
Echinococcus multilocularis snurportin 1 0.0361 0.5675 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0033 0.0383 0.0675
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0149
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0441 0.0778
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0077 0.1082 0.1907
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0017 0.0005
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0023 0.005
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0015 0.0084 0.0062
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0244 0.0542
Schistosoma mansoni troponin t invertebrate 0.0146 0.2205 0.2819
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0143 0.2151 0.2736
Schistosoma mansoni hypothetical protein 0.0061 0.0832 0.1064
Schistosoma mansoni hypothetical protein 0.0115 0.1703 0.2177
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0017 0.0031
Onchocerca volvulus Troponin I homolog 0.0118 0.1747 0.6885
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0389 0.0884
Plasmodium falciparum cyclin 0.0017 0.0119 0.1492
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1535 0.3328
Loa Loa (eye worm) hypothetical protein 0.0017 0.0119 0.021
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0084 0.0355
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.1535 0.1962
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.005 0.0044
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0093 0.0201
Brugia malayi MH1 domain containing protein 0.001 0.001 0.0022
Echinococcus granulosus dual specificity 0.0095 0.1377 0.2427
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.215 0.2131

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 75 nM Displacement of [125I]Ang2 from AT2 receptor in pig uterus membrane ChEMBL. 17125268
Ki (binding) = 75 nM Displacement of [125I]Ang2 from AT2 receptor in pig uterus membrane ChEMBL. 17125268
Ki (binding) > 10000 nM Displacement of [125I]Ang2 from AT2 receptor in rat liver membrane ChEMBL. 17125268
Ki (binding) > 10000 nM Displacement of [125I]Ang2 from AT2 receptor in rat liver membrane ChEMBL. 17125268

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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