Detailed information for compound 411167

Basic information

Technical information
  • TDR Targets ID: 411167
  • Name: (2S,3R,4S,5R,6R)-2-[(2S,3S,4R)-2-(4-hexadecyl triazol-1-yl)-3,4-dihydroxyoctadecoxy]-6-(hyd roxymethyl)oxane-3,4,5-triol
  • MW: 756.108 | Formula: C42H81N3O8
  • H donors: 6 H acceptors: 8 LogP: 11.58 Rotable bonds: 35
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCCCCCCCCCCCCCCc1nnn(c1)[C@H]([C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)CO[C@H]1O[C@H](CO)[C@@H]([C@@H]([C@H]1O)O)O
  • InChi: 1S/C42H81N3O8/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-34-31-45(44-43-34)35(33-52-42-41(51)40(50)39(49)37(32-46)53-42)38(48)36(47)30-28-26-24-22-20-16-14-12-10-8-6-4-2/h31,35-42,46-51H,3-30,32-33H2,1-2H3/t35-,36+,37+,38-,39-,40-,41+,42-/m0/s1
  • InChiKey: RNDXMEKYKSSAMK-GGTYJKCDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3R,4S,5R,6R)-2-[(2S,3S,4R)-2-(4-hexadecyltriazol-1-yl)-3,4-dihydroxy-octadecoxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
  • (2S,3R,4S,5R,6R)-2-[(2S,3S,4R)-2-(4-hexadecyl-1-triazolyl)-3,4-dihydroxyoctadecoxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
  • (2S,3R,4S,5R,6R)-2-[(2S,3S,4R)-2-(4-hexadecyl-1,2,3-triazol-1-yl)-3,4-dihydroxy-octadecoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • (2S,3R,4S,5R,6R)-2-[(2S,3S,4R)-2-(4-cetyltriazol-1-yl)-3,4-dihydroxy-octadecoxy]-6-methylol-tetrahydropyran-3,4,5-triol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0637 0.7167 1
Echinococcus granulosus fmrfamide receptor 0.0637 0.7167 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0023 0.0137 0.0173
Schistosoma mansoni carbonic anhydrase-related 0.0252 0.2762 0.3851
Brugia malayi Dopamine receptor 0.0637 0.7167 0.7167
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0137 0.0373
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Mycobacterium ulcerans epimerase 0.0022 0.0126 0.0382
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0537 0.6018 1
Brugia malayi putative neuropeptide receptor NPR1 0.0637 0.7167 0.7167
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0184 0.1985 0.3201
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0637 0.7167 0.7167
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0082 0.0822 0.0822
Echinococcus granulosus neuropeptide Y receptor 0.0637 0.7167 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0637 0.7167 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0313 0.3654
Schistosoma mansoni carbonic anhydrase-related 0.0252 0.2762 0.3851
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0023 0.0137 0.0086
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0637 0.7167 0.7959
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0115 0.0156
Echinococcus granulosus orexin receptor type 2 0.0637 0.7167 1
Schistosoma mansoni hypothetical protein 0.0252 0.2762 0.3851
Echinococcus multilocularis somatostatin receptor 0.0637 0.7167 0.7959
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0184 0.1985 0.326
Schistosoma mansoni neuropeptide F-like receptor 0.0637 0.7167 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.0664
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.0664
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0086 0.011
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0308 0.0374
Onchocerca volvulus 0.0637 0.7167 1
Brugia malayi RE15519p 0.0637 0.7167 0.7167
Mycobacterium leprae putative cytochrome p450 0.0018 0.0086 0.0477
Echinococcus multilocularis neuropeptide receptor A26 0.0637 0.7167 0.7959
Onchocerca volvulus 0.0256 0.2804 0.3884
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0637 0.7167 0.7959
Echinococcus granulosus tar DNA binding protein 0.0062 0.0591 0.082
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0218 0.0595
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0537 0.6018 0.6018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0415 0.0574
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0542 0.1795
Echinococcus granulosus sex peptide receptor 0.0637 0.7167 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0243 0.0334
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0209 0.0209
Echinococcus multilocularis g-protein coupled receptor 0.0637 0.7167 0.7959
Schistosoma mansoni biogenic amine (5HT) receptor 0.0637 0.7167 1
Schistosoma mansoni carbonic anhydrase 0.0252 0.2762 0.3851
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0253 0.0348
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0415 0.0457
Loa Loa (eye worm) hypothetical protein 0.0025 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0137 0.0173
Echinococcus granulosus hypothetical protein 0.0637 0.7167 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0035 0.0277 0.0304
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0252 0.2762 0.2762
Brugia malayi Protein kinase domain containing protein 0.0065 0.0618 0.0618
Echinococcus granulosus metabotropic glutamate receptor 2 0.0035 0.0277 0.0381
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0003 0.0003
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0065 0.0618 0.0977
Plasmodium vivax hypothetical protein, conserved 0.0073 0.071 0.8372
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0115 0.0115
Schistosoma mansoni protein kinase 0.0629 0.7079 0.9877
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus granulosus neuropeptides capa receptor 0.0637 0.7167 1
Chlamydia trachomatis endonuclease IV 0.0082 0.0822 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0808 0.0808
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0542 0.085
Brugia malayi hypoxia-induced factor 1 0.0162 0.1732 0.1732
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0126 0.013
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0308 0.0425
Onchocerca volvulus 0.0637 0.7167 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1135 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0218 0.0664
Loa Loa (eye worm) melatonin receptor type 1A 0.0637 0.7167 0.7167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0637 0.7167 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0313 0.0382
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0115 0.0124
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.0137 0.0186
Entamoeba histolytica hypothetical protein 0.0072 0.0699 0.5246
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0115 0.0124
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.0664
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.082
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0626 0.5144
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.0137 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0115 0.0115
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0176 0.0192
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0296 0.0438
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0637 0.7167 1
Onchocerca volvulus 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Toxoplasma gondii hypothetical protein 0.0059 0.0549 0.1821
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0637 0.7167 0.7959
Leishmania major protein kinase, putative 0.0065 0.0618 0.0977
Loa Loa (eye worm) hypothetical protein 0.0074 0.0719 0.0719
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0115 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0637 0.7167 0.7959
Echinococcus granulosus dual specificity protein kinase clk2 0.0065 0.0618 0.0858
Echinococcus multilocularis muscleblind protein 0.0147 0.1559 0.1728
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0626 0.0869
Echinococcus multilocularis 0.0018 0.0086 0.0092
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0313 0.1037
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1135 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0065 0.0618 0.0897
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0252 0.2762 0.2762
Schistosoma mansoni neuropeptide f receptor 76f 0.0637 0.7167 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0126 0.0078
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0023 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0059 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Mycobacterium leprae conserved hypothetical protein 0.0073 0.071 0.6144
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0785 0.0868
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Onchocerca volvulus 0.0637 0.7167 1
Schistosoma mansoni hypothetical protein 0.0032 0.0243 0.0334
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0637 0.7167 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0184 0.1985 0.2766
Brugia malayi protein C17H12.11 0.0241 0.2631 0.2631
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0637 0.7167 1
Brugia malayi sulfakinin receptor protein 0.0637 0.7167 0.7167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0415 0.0574
Echinococcus multilocularis lamin 0.0054 0.0495 0.0546
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.1015 0.1015
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0137 0.0086
Onchocerca volvulus 0.0073 0.071 0.0949
Schistosoma mansoni cpg binding protein 0.0031 0.0231 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0637 0.7167 1
Mycobacterium ulcerans endonuclease IV 0.0082 0.0822 0.7014
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0308 0.0338
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1135 0.158
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0308 0.0458
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0115 0.0156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0115 0.0124
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0637 0.7167 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0637 0.7167 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0499 0.5593 0.621
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.0719 0.0999
Echinococcus granulosus rhodopsin orphan GPCR 0.0637 0.7167 1
Echinococcus multilocularis fmrfamide receptor 0.0637 0.7167 0.7959
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0542 0.085
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0313 0.1008
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0637 0.7167 0.7167
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.071 0.1131
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Loa Loa (eye worm) hypothetical protein 0.0147 0.1559 0.1559
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0286 0.3148 0.3493
Echinococcus granulosus rhodopsin orphan GPCR 0.0637 0.7167 1
Echinococcus granulosus carbonic anhydrase 0.0252 0.2762 0.3851
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0081 0.0808 0.2797
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0065 0.0618 0.0977
Schistosoma mansoni cytochrome P450 0.0018 0.0086 0.0116
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0137 0.0373
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0542 0.085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0115 0.0115
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0184 0.1985 0.7047
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0495 0.0495
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0115 0.0115
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0184 0.1985 0.7047
Leishmania major protein kinase, putative 0.0065 0.0618 0.0977
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0115 0.0115
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0666 0.0666
Echinococcus multilocularis G-protein coupled receptor, putative 0.0637 0.7167 0.7959
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.071 0.1222
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0023 0.0137 0.0186
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Brugia malayi Cytochrome P450 family protein 0.0037 0.0296 0.0296
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0313 0.0466
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Schistosoma mansoni cpg binding protein 0.0031 0.0231 0.0318
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0115 0.0115
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1135 0.158
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0699 0.0773
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0115 0.0115
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0065 0.0618 0.0977
Schistosoma mansoni single-minded 0.0052 0.0477 0.0661
Schistosoma mansoni neuropeptide receptor 0.0637 0.7167 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0415 0.0574
Schistosoma mansoni hypothetical protein 0.0637 0.7167 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0115 0.0156
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0243 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0137 0.0373
Brugia malayi Dopamine receptor protein 1 0.0637 0.7167 0.7167
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0499 0.5593 0.9283
Echinococcus granulosus mitogen activated protein kinase 11 0.0499 0.5593 0.7802
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0415 0.0574
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0415 0.0574
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0082 0.0822 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0059 0.0549 0.4414
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0253 0.0348
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.071 0.2444
Mycobacterium ulcerans putative regulatory protein 0.0059 0.0549 0.4414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0637 0.7167 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0086 0.0088
Echinococcus multilocularis TGF beta receptor type 1 0.0629 0.7079 0.7861
Brugia malayi hypothetical protein 0.0176 0.1888 0.1888
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0137 0.0148
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0137 0.0373
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0218 0.2334
Echinococcus granulosus tm gpcr rhodopsin 0.0637 0.7167 1
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1135 0.1841
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.071 0.0987
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0034 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1726 0.6112
Echinococcus multilocularis orexin receptor type 2 0.0637 0.7167 0.7959
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0637 0.7167 0.7959
Brugia malayi Pre-SET motif family protein 0.0225 0.2448 0.2448
Onchocerca volvulus 0.0073 0.071 0.0949
Echinococcus multilocularis neuropeptide Y receptor 0.0637 0.7167 0.7959
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0137 0.0186
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0137 0.0186
Schistosoma mansoni lamin 0.0054 0.0495 0.0686
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus granulosus biogenic amine 5HT receptor 0.0637 0.7167 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0243 0.0266
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.9004 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0313 0.0466
Loa Loa (eye worm) beta-lactamase 0.0073 0.071 0.071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1031 0.1031
Brugia malayi GnHR receptor homolog 0.0637 0.7167 0.7167
Echinococcus granulosus metabotropic glutamate receptor 5 0.0051 0.0464 0.0643
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis mitogen activated protein kinase 14 0.0499 0.5593 0.621
Onchocerca volvulus 0.0637 0.7167 1
Onchocerca volvulus 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0184 0.1985 0.7047
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) neuropeptide F receptor 0.0637 0.7167 0.7167
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0313 0.1008
Echinococcus granulosus activin receptor type 0.0286 0.3148 0.4389
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0626 0.5144
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.1139 0.1586
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0308 0.0338
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0308 0.0338
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1135 0.3978
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0137 0.0173
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0243 0.0266
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0176 0.0241
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0074 0.0719 0.2476
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0618 0.2111
Brugia malayi beta-lactamase family protein 0.0073 0.071 0.071
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0537 0.6018 0.6018
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Schistosoma mansoni hypothetical protein 0.0018 0.0086 0.0116
Echinococcus granulosus neuropeptide s receptor 0.0637 0.7167 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0137 0.0186
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0184 0.1985 0.2201
Echinococcus granulosus cpg binding protein 0.0031 0.0231 0.0318
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0465 0.5196 1
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0495 0.0495
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0252 0.2762 0.2762
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0072
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0637 0.7167 1
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0126 0.0126
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0591 0.0591
Echinococcus granulosus neuropeptide receptor 0.0637 0.7167 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0115 0.0115
Echinococcus granulosus death domain containing protein 0.0015 0.0055 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0499 0.5593 0.9289
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0115 0.0124
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Plasmodium vivax serine/threonine kinase-1, putative 0.0065 0.0618 0.7025
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0637 0.7167 1
Giardia lamblia Kinase, CMGC CLK 0.0065 0.0618 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0542 0.0598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0637 0.7167 0.7959
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0076 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.082
Brugia malayi TAR-binding protein 0.0062 0.0591 0.0591
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0115 0.0115
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.011 0.011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0313 0.0466
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0626 0.2104
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.082
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.0664
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0626 0.5144
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0218 0.1177
Echinococcus granulosus GPCR family 2 0.0032 0.0243 0.0334
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1559 0.1728
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0499 0.5593 0.9289
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0499 0.5593 0.9289
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0184 0.1985 0.3201
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0308 0.0458
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0137 0.0186
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0184 0.1985 0.326
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0023 0.0137 0.0173
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1135 0.1135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0115 0.0115
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0542 0.085
Brugia malayi Muscleblind-like protein 0.0147 0.1559 0.1559
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0061 0.0576 0.0576
Brugia malayi Dopamine receptor protein 2 0.0637 0.7167 0.7167
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0241 0.2631 0.2631
Loa Loa (eye worm) hypothetical protein 0.0101 0.1031 0.1031
Schistosoma mansoni amine GPCR 0.0637 0.7167 1
Brugia malayi beta-lactamase 0.0073 0.071 0.071
Mycobacterium ulcerans hypothetical protein 0.0073 0.071 0.5951
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0415 0.0457
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0115 0.0156
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0637 0.7167 1
Echinococcus granulosus neuropeptide receptor 0.0637 0.7167 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0637 0.7167 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0023 0.0137 0.0086
Echinococcus granulosus serotonin receptor 0.0637 0.7167 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1135 1
Brugia malayi AKH receptor 0.0637 0.7167 0.7167
Brugia malayi nuclear hormone receptor 0.0021 0.0115 0.0115
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0065 0.0618 0.2076
Brugia malayi Protein kinase domain containing protein 0.0019 0.0097 0.0097
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.0137 0.0186
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0524 0.1729
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.053 0.053
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0023 0.0137 0.0373
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.1732 0.1732
Schistosoma mansoni metabotropic glutamate receptor 0.0035 0.0277 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0115 0.0115
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0047 0.0419 0.058
Brugia malayi Uncoordinated protein 44 0.0015 0.0055 0.0055
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0125 0.1314 0.4623
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0115 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0477 0.0661
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0591 0.0591
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0885 1 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0059 0.0549 0.0906
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1135 1
Schistosoma mansoni cpg binding protein 0.0029 0.0212 0.0291
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0313 0.0443
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1135 0.158
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0637 0.7167 0.7959
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.071 0.0785
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0137 0.0173
Onchocerca volvulus 0.0637 0.7167 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1726 0.6112
Echinococcus granulosus dro:myosuppressin receptor 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.1559 0.1559
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0252 0.2762 0.2762
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0086 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0137 0.0173
Onchocerca volvulus 0.0637 0.7167 1
Schistosoma mansoni amine GPCR 0.0637 0.7167 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0499 0.5593 0.7802
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0115 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0137 0.0173
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0637 0.7167 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.071 0.2444
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0542 0.0542
Leishmania major protein kinase, putative 0.0017 0.0076 0.0071
Onchocerca volvulus 0.0637 0.7167 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0231 0.0253
Loa Loa (eye worm) carbonic anhydrase 3 0.0537 0.6018 0.6018
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0637 0.7167 0.7959
Mycobacterium ulcerans beta-lactamase 0.0073 0.071 0.5951
Leishmania major cytochrome p450-like protein 0.0018 0.0086 0.0088
Schistosoma mansoni biogenic amine receptor 0.0637 0.7167 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0308 0.0991
Loa Loa (eye worm) hypothetical protein 0.0073 0.071 0.071
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0137 0.0137
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0115 0.0156
Brugia malayi G protein-coupled receptor F59B2.13 0.0637 0.7167 0.7167
Plasmodium falciparum GAF domain-related protein, putative 0.0059 0.0549 0.157
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0137 0.0373
Loa Loa (eye worm) hypothetical protein 0.0252 0.2762 0.2762
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0308 0.0425
Schistosoma mansoni alpha-1 adrenergic receptor 0.0637 0.7167 1
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0321 0.2242
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0699 0.0971
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0137 0.0173
Leishmania major hypothetical protein, conserved 0.0023 0.0137 0.0173
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0243 0.0266
Brugia malayi RNA binding protein 0.0062 0.0591 0.0591
Echinococcus multilocularis carbonic anhydrase II 0.0537 0.6018 0.6682
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.011 0.0149
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0065 0.0618 0.0977
Brugia malayi ORL1-like opioid receptor 0.0637 0.7167 0.7167
Schistosoma mansoni opsin-like receptor 0.0637 0.7167 1
Brugia malayi putative neuropeptide receptor 0.0637 0.7167 0.7167
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0115 0.0156
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0637 0.7167 0.7959
Loa Loa (eye worm) hypothetical protein 0.0073 0.071 0.071
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus biogenic amine 5HT receptor 0.0637 0.7167 1
Echinococcus multilocularis carbonic anhydrase 0.0252 0.2762 0.3065
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0296 0.0296
Echinococcus multilocularis neuropeptide s receptor 0.0637 0.7167 0.7959
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0137 0.0373
Onchocerca volvulus 0.0637 0.7167 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0023 0.0137 0.0186
Brugia malayi Melatonin receptor type 1A 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0137
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0115 0.0156
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0542 0.0598
Brugia malayi Tachykinin-like peptides receptor 99D 0.0637 0.7167 0.7167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0637 0.7167 0.7959
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0115 0.0115
Mycobacterium tuberculosis Conserved protein 0.0073 0.071 0.1222
Echinococcus granulosus tachykinin peptides receptor 99D 0.0637 0.7167 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0115 0.0124
Brugia malayi Serotonin receptor 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus granulosus peptide allatostatin:somatostatin 0.0637 0.7167 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0313 0.0432
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0034 0.0034
Echinococcus granulosus muscleblind protein 0.0147 0.1559 0.2172
Echinococcus granulosus rhodopsin orphan GPCR 0.0637 0.7167 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0637 0.7167 1
Schistosoma mansoni histamine h1 receptor 0.0637 0.7167 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0296 0.0354
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0059 0.0549 0.0906
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0637 0.7167 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0023 0.0137 0.0137
Brugia malayi hypothetical protein 0.0487 0.5452 0.5452
Echinococcus multilocularis neuropeptide FF receptor 2 0.0637 0.7167 0.7959
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.071 0.1222
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis serotonin receptor 0.0637 0.7167 0.7959
Echinococcus granulosus dnaJ subfamily B 0.0416 0.4635 0.6465
Echinococcus granulosus rhodopsin orphan GPCR 0.0637 0.7167 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0637 0.7167 1
Echinococcus granulosus g-protein coupled receptor 0.0637 0.7167 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0637 0.7167 1
Mycobacterium ulcerans putative regulatory protein 0.0059 0.0549 0.4414
Brugia malayi Cytochrome P450 family protein 0.0037 0.0296 0.0296
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0637 0.7167 0.7167
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0308 0.3555
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.1139 0.1586
Echinococcus granulosus tm gpcr rhodopsin 0.0637 0.7167 1
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Schistosoma mansoni opsin-like receptor 0.0637 0.7167 1
Echinococcus granulosus carbonic anhydrase II 0.0537 0.6018 0.8396
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.071 0.1222
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0137 0.0148
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0308 0.0458
Toxoplasma gondii hypothetical protein 0.0059 0.0549 0.1821
Onchocerca volvulus 0.0637 0.7167 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0115 0.0156
Loa Loa (eye worm) neuropeptide F receptor 0.0637 0.7167 0.7167
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0252 0.2762 0.2762
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.071 0.1222
Brugia malayi phosphofructokinase 0.011 0.1135 0.1135
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1135 0.1841
Schistosoma mansoni hypothetical protein 0.0032 0.0243 0.0334
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.4635 0.5146
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Schistosoma mansoni hypothetical protein 0.0416 0.4635 0.6465
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0055 0.0055
Mycobacterium leprae Probable lipase LipE 0.0073 0.071 0.6144
Schistosoma mansoni amine GPCR 0.0637 0.7167 1
Echinococcus multilocularis carbonic anhydrase 0.0252 0.2762 0.3065
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0055 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0126 0.0126
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0296 0.2
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0542 0.1836
Brugia malayi cytochrome P450 0.0018 0.0086 0.0086
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0086 0.0116
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0184 0.1985 0.7047
Echinococcus multilocularis activin receptor type 0.0286 0.3148 0.3493
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0137 0.0186
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0115 0.0156
Entamoeba histolytica hypothetical protein 0.0072 0.0699 0.5246
Loa Loa (eye worm) hypothetical protein 0.0026 0.0176 0.0176
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.071 0.0987
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0637 0.7167 0.7959
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0086 0.0477
Echinococcus multilocularis neuropeptide receptor 0.0637 0.7167 0.7959
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0244 0.2673 0.2673
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0023 0.0137 0.0373
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0082 0.0822 0.0822
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1135 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.071 0.1222
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0082 0.0822 0.7156
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0542 0.0769
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0081 0.0808 0.1123
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Toxoplasma gondii melibiase subfamily protein 0.011 0.1139 0.4002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0055
Brugia malayi bone morphogenetic protein type 1 receptor 0.0626 0.7037 0.7037
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0637 0.7167 0.7959
Onchocerca volvulus 0.0637 0.7167 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1985 0.7047
Toxoplasma gondii GAF domain-containing protein 0.0059 0.0549 0.1821
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0637 0.7167 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0537 0.6018 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.1139 0.1586
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0542 0.0752
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1985 0.7047
Brugia malayi MAP kinase sur-1 0.0058 0.0542 0.0542
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1031 0.1031
Schistosoma mansoni neuropeptide receptor 0.0637 0.7167 1
Brugia malayi ecdysteroid receptor 0.0021 0.0115 0.0115
Onchocerca volvulus 0.0029 0.0212 0.025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0637 0.7167 0.7959
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0637 0.7167 0.7959
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0243 0.0334
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.071 0.2444
Brugia malayi Pre-SET motif family protein 0.0033 0.0253 0.0253
Plasmodium falciparum carbonic anhydrase 0.0252 0.2762 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0542 0.085
Leishmania major protein kinase, putative 0.0017 0.0076 0.0071
Schistosoma mansoni ap endonuclease 0.0038 0.0313 0.0432
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0076 0.0071
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1031 0.1031
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0637 0.7167 0.7959
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0088
Brugia malayi hypothetical protein 0.0241 0.2631 0.2631
Onchocerca volvulus 0.0637 0.7167 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Onchocerca volvulus 0.0099 0.1015 0.1375
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0243 0.0243
Echinococcus granulosus g protein coupled receptor 0.0637 0.7167 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0042 0.0354 0.0354
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1135 0.3978
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0023 0.0137 0.0137
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1985 0.7047
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0321 0.0353
Toxoplasma gondii exonuclease III APE 0.0038 0.0313 0.0947
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0252 0.2762 0.2762
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1135 0.1135
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.011 0.1139 0.1262
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0218 0.0307
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0542 0.0752
Echinococcus multilocularis sex peptide receptor 0.0637 0.7167 0.7959
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.082
Echinococcus multilocularis survival motor neuron protein 1 0.0487 0.5452 0.6053
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0637 0.7167 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0081 0.0808 0.0894
Loa Loa (eye worm) hypothetical protein 0.0053 0.0484 0.0484
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0296 0.0438
Echinococcus granulosus G protein coupled receptor 139 0.0637 0.7167 1
Loa Loa (eye worm) cytochrome P450 0.0018 0.0086 0.0086
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0137 0.0186
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0115 0.0124
Echinococcus multilocularis neuropeptides capa receptor 0.0637 0.7167 0.7959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0637 0.7167 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0115 0.0115
Schistosoma mansoni survival motor neuron protein 0.0099 0.1015 0.1412
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0218 0.0664
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0184 0.1985 0.7047
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1135 0.3978
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0137 0.0186
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0296 0.0296
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0313 0.216
Echinococcus granulosus g protein coupled receptor 0.0637 0.7167 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0057 0.0074
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0637 0.7167 0.7167
Trichomonas vaginalis set domain proteins, putative 0.0256 0.2802 1
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1985 0.7047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0253 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1726 0.6112
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0542 0.1836
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0137 0.0373
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0082 0.0822 0.2609
Schistosoma mansoni hypothetical protein 0.0069 0.0666 0.0925
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0115 0.0156
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1135 0.1768
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0626 0.0691
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1985 0.7047
Echinococcus granulosus neuropeptide Y receptor 0.0637 0.7167 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Onchocerca volvulus 0.0054 0.0495 0.0647
Schistosoma mansoni hypothetical protein 0.0032 0.0243 0.0334
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0081 0.0808 0.0808
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0115 0.0115
Brugia malayi Melibiase family protein 0.0074 0.0719 0.0719
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0232 0.0319
Brugia malayi Cytochrome P450 family protein 0.0018 0.0086 0.0086
Echinococcus granulosus single minded 2 0.0039 0.0321 0.0444
Echinococcus granulosus allatostatin A receptor 0.0637 0.7167 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0499 0.5593 0.621
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0055 0.003
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0549 0.6018
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0076 0.0071
Schistosoma mansoni lamin 0.0054 0.0495 0.0686
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0637 0.7167 0.7959
Echinococcus granulosus g protein coupled receptor 0.0637 0.7167 1
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0055 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0549 0.1862
Plasmodium falciparum protein serine/threonine kinase-1 0.0065 0.0618 0.1833
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0115 0.0124
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0495 0.0495
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0126 0.0382
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0126 0.084
Schistosoma mansoni amine GPCR 0.0637 0.7167 1
Echinococcus multilocularis g protein coupled receptor 0.0637 0.7167 0.7959
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.071 0.1052
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0308 0.0425
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0115 0.0156
Loa Loa (eye worm) G-protein coupled receptor 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0034
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0542 0.0752
Brugia malayi Serotonin receptor 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.0137 0.0148
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0637 0.7167 1
Schistosoma mansoni carbonic anhydrase-related 0.0252 0.2762 0.3851
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0253 0.0348
Echinococcus granulosus lamin 0.0054 0.0495 0.0686
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1985 0.7047
Echinococcus granulosus TGF beta receptor type 1 0.0629 0.7079 0.9877
Brugia malayi G-protein coupled receptor 0.0637 0.7167 0.7167
Schistosoma mansoni hypothetical protein 0.0637 0.7167 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0218 0.0595
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0125 0.1314 0.2139
Echinococcus granulosus carbonic anhydrase 0.0252 0.2762 0.3851
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0313 0.067
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Brugia malayi beta-lactamase family protein 0.0073 0.071 0.071
Echinococcus granulosus rhodopsin orphan GPCR 0.0637 0.7167 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0023 0.0137 0.0148
Loa Loa (eye worm) glutamate receptor 0.0016 0.0065 0.0065
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0253 0.0277
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0313 0.0313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0115 0.0124
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.0719 0.0999
Mycobacterium leprae conserved hypothetical protein 0.0059 0.0549 0.468
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0081 0.0808 0.2797
Echinococcus granulosus somatostatin receptor 0.0637 0.7167 1
Leishmania major hypothetical protein, conserved 0.0023 0.0137 0.0173
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0537 0.6018 0.8396
Onchocerca volvulus 0.0637 0.7167 1
Schistosoma mansoni hypothetical protein 0.0032 0.0243 0.0334
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0023 0.0137 0.0186
Loa Loa (eye worm) hypothetical protein 0.0025 0.0165 0.0165
Schistosoma mansoni amine GPCR 0.0637 0.7167 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0055 0.0055
Schistosoma mansoni netrin receptor unc5 0.0015 0.0055 0.0072
Brugia malayi 6-phosphofructokinase 0.011 0.1135 0.1135
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0115 0.0115
Leishmania major hypothetical protein, conserved 0.0073 0.071 0.1131
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0038 0.0309 0.0309
Schistosoma mansoni biogenic amine (5HT) receptor 0.0637 0.7167 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0086 0.0088
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0626 0.0989
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0073 0.071 0.071
Toxoplasma gondii hypothetical protein 0.0252 0.2762 1
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0055 0.0072
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis Ankyrin 0.0016 0.0057 0.0059
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0537 0.6018 0.6018
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0023 0.0137 0.0148
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0637 0.7167 1
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0137 0.0173
Schistosoma mansoni biogenic amine receptor 0.0637 0.7167 1
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0542 0.1836
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0081 0.0808 0.1123
Loa Loa (eye worm) PDE1B protein 0.0023 0.0137 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0115 0.0115
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0537 0.6018 1
Loa Loa (eye worm) glutamate receptor 0.0042 0.0354 0.0354
Brugia malayi nuclear receptor NHR-88 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0184 0.1985 0.326
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0313 0.5
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Plasmodium vivax SET domain protein, putative 0.0033 0.0253 0.1692
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0034 0.0042
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0076 0.0071
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0626 0.7037 0.7037
Schistosoma mansoni ap endonuclease 0.0038 0.0313 0.0432
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0296 0.0296
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0115 0.0156
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0055 0.0057
Brugia malayi PAS domain containing protein 0.0052 0.0477 0.0477
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0637 0.7167 0.7959
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0637 0.7167 0.7959
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.071 0.5951
Echinococcus granulosus survival motor neuron protein 1 0.0487 0.5452 0.7605
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0137 0.0137
Echinococcus multilocularis lamin dm0 0.0054 0.0495 0.0546
Onchocerca volvulus 0.0054 0.0495 0.0647
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0253 0.0348
Loa Loa (eye worm) hypothetical protein 0.0487 0.5452 0.5452
Echinococcus multilocularis neuropeptide Y receptor 0.0637 0.7167 0.7959
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0618 0.0858
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1135 0.3978
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0137 0.0373
Schistosoma mansoni opsin-like receptor 0.0637 0.7167 1
Onchocerca volvulus 0.0637 0.7167 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0591 0.0591
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0618 0.0858
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0115 0.0156
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0591 0.0591
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0244 0.2673 0.2673
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0308 0.0991
Brugia malayi nuclear receptor RXR 0.0011 0.0003 0.0003
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0637 0.7167 0.7167
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0243 0.0243
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0637 0.7167 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0051 0.0464 0.0512
Echinococcus granulosus neuropeptide FF receptor 2 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0137
Echinococcus granulosus carbonic anhydrase 0.0252 0.2762 0.3851
Mycobacterium ulcerans lipase LipD 0.0073 0.071 0.5951
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0115 0.0156
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0313 0.1037
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0637 0.7167 0.7167
Onchocerca volvulus Neuropeptide F receptor homolog 0.0637 0.7167 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0637 0.7167 0.7959
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0253 0.0277
Echinococcus granulosus lamin dm0 0.0054 0.0495 0.0686
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0115 0.0156
Echinococcus granulosus rhodopsin orphan GPCR 0.0637 0.7167 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0308 0.0991
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0542 0.085
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0308 0.0986
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.071 0.071
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0137 0.0373
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Onchocerca volvulus 0.0033 0.0253 0.0307
Echinococcus multilocularis allatostatin A receptor 0.0637 0.7167 0.7959
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0626 0.0869
Toxoplasma gondii endonuclease IV APN 0.0082 0.0822 0.2829
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0253 0.0348
Schistosoma mansoni myosin xvIII 0.0637 0.7167 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0637 0.7167 1
Schistosoma mansoni intermediate filament proteins 0.0054 0.0495 0.0686
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0115 0.0156
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.011 0.1139 0.1586
Loa Loa (eye worm) hypothetical protein 0.0252 0.2762 0.2762
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0137 0.0086
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0637 0.7167 0.7167
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Echinococcus multilocularis 0.0061 0.0576 0.0636
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.071 0.1222
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0137 0.0186
Entamoeba histolytica hypothetical protein 0.0072 0.0699 0.5246
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0591 0.0653
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.071 0.071
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0626 0.1056
Echinococcus granulosus Ankyrin 0.0016 0.0057 0.0074
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0082 0.0822 0.144
Schistosoma mansoni hypothetical protein 0.0637 0.7167 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0137 0.0173
Loa Loa (eye worm) G-protein coupled receptor 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Onchocerca volvulus 0.0637 0.7167 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0464 0.0464
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0209 0.0209
Brugia malayi P38 map kinase family protein 2 0.0499 0.5593 0.5593
Echinococcus multilocularis carbonic anhydrase 0.0252 0.2762 0.3065
Brugia malayi neuropeptide F receptor 0.0637 0.7167 0.7167
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0499 0.5593 0.5593
Schistosoma mansoni neuropeptide F-like receptor 0.0637 0.7167 1
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0055 0.0057
Brugia malayi larval opioid receptor 0.0637 0.7167 0.7167
Leishmania major carbonic anhydrase-like protein 0.0537 0.6018 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.2448 0.2448
Schistosoma mansoni hypothetical protein 0.0099 0.1015 0.1412
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0137
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0072 0.0699 0.0971
Brugia malayi intermediate filament protein 0.0054 0.0495 0.0495
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0218 0.1676
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.071 0.5951
Schistosoma mansoni neuropeptide receptor 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.071 0.071
Mycobacterium tuberculosis Conserved protein 0.0073 0.071 0.1222
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.1139 0.1586
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0184 0.1985 0.7047
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0023 0.0137 0.0173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.071 0.0987
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0253 0.0726
Echinococcus granulosus tm gpcr rhodopsin 0.0637 0.7167 1
Echinococcus multilocularis serotonin receptor 0.0637 0.7167 0.7959
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0115 0.0156
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0125 0.1314 0.4623
Toxoplasma gondii ABC1 family protein 0.0073 0.071 0.2417
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1135 0.1257
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0415 0.0415
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0218 0.0307
Echinococcus granulosus hypothetical protein 0.0061 0.0576 0.0799
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0542 0.1836
Echinococcus multilocularis dro:myosuppressin receptor 0.0637 0.7167 0.7959
Trypanosoma brucei protein kinase, putative 0.0058 0.0542 0.0769
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Brugia malayi G-protein coupled receptor 0.0637 0.7167 0.7167
Brugia malayi neuropeptide F receptor 0.0637 0.7167 0.7167
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0115 0.0115
Echinococcus granulosus neuropeptide receptor A26 0.0637 0.7167 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0065 0.0618 0.0897
Echinococcus granulosus neuropeptides capa receptor 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0637 0.7167 0.7959
Loa Loa (eye worm) phosphofructokinase 0.011 0.1135 0.1135
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0086 0.0088
Onchocerca volvulus 0.0637 0.7167 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0243 0.0243
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.071 0.1222
Schistosoma mansoni biogenic amine receptor 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis G protein coupled receptor 139 0.0637 0.7167 0.7959
Echinococcus multilocularis musashi 0.0054 0.0495 0.0546
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0137 0.0186
Echinococcus granulosus TGF-beta receptor type-1 0.0629 0.7079 0.9877
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0637 0.7167 1
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0699 0.0971
Schistosoma mansoni hypothetical protein 0.0637 0.7167 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0252 0.2762 0.2762
Onchocerca volvulus 0.0039 0.0321 0.0403
Echinococcus multilocularis g protein coupled receptor 0.0637 0.7167 0.7959
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0321 0.0321
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis mitogen activated protein kinase 11 0.0499 0.5593 0.621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0115 0.0115
Echinococcus granulosus 7tm_1 domain containing protein 0.0637 0.7167 1
Mycobacterium ulcerans hypothetical protein 0.0022 0.0126 0.0382
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0137 0.0086
Loa Loa (eye worm) hypothetical protein 0.0069 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0054 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0073 0.071 0.071
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Schistosoma mansoni coup transcription factor 0.0021 0.0115 0.0156
Schistosoma mansoni protein kinase 0.0282 0.3105 0.433
Echinococcus granulosus alpha 1A adrenergic receptor 0.0637 0.7167 1
Entamoeba histolytica hypothetical protein 0.0072 0.0699 0.5246
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0057 0.0074
Echinococcus multilocularis dual specificity protein kinase clk2 0.0065 0.0618 0.0683
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0313 0.0344
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0637 0.7167 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0218 0.0595
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0137 0.0373
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0537 0.6018 0.8396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0308 0.0425
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0785 0.1091
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0218 0.1177
Leishmania major cytochrome p450-like protein 0.0018 0.0086 0.0088
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.071 0.2444
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0115 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0115 0.0156
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0115 0.0156
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.071 0.1222
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Onchocerca volvulus 0.0073 0.071 0.0949
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1135 1
Brugia malayi Cytochrome P450 family protein 0.0057 0.053 0.053
Brugia malayi CXXC zinc finger family protein 0.0029 0.0212 0.0212
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0626 0.0869
Onchocerca volvulus 0.0637 0.7167 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0115 0.0115
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0023 0.0137 0.0173
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.06 0.0833
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0218 0.2334
Schistosoma mansoni neuropeptide receptor 0.0637 0.7167 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0184 0.1985 0.2766
Loa Loa (eye worm) TYRA-2 protein 0.0637 0.7167 0.7167
Echinococcus granulosus intermediate filament protein 0.0054 0.0495 0.0686
Brugia malayi hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0637 0.7167 0.7959
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0313 0.2567
Echinococcus multilocularis g protein coupled receptor 0.0637 0.7167 0.7959
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0081 0.0808 0.0808
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1985 0.7047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0637 0.7167 0.7959
Trichomonas vaginalis esterase, putative 0.0073 0.071 0.2444
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Brugia malayi G protein-coupled receptor 0.0637 0.7167 0.7167
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.071 0.2444
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0637 0.7167 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0637 0.7167 0.7167
Brugia malayi Death domain containing protein 0.0015 0.0055 0.0055
Leishmania major cytochrome p450-like protein 0.0037 0.0296 0.0438
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1135 0.2053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0313 0.0313
Brugia malayi 6-phosphofructokinase 0.011 0.1136 0.1136
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0065 0.0618 0.0618
Schistosoma mansoni adenoreceptor 0.0637 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0637 0.7167 0.7167
Echinococcus multilocularis fmrfamide receptor 0.0637 0.7167 0.7959
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.071 0.1131
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0081 0.0808 0.2797
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0023 0.0137 0.0186
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0308 0.0308
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Loa Loa (eye worm) hypothetical protein 0.0176 0.1888 0.1888
Toxoplasma gondii hypothetical protein 0.0161 0.1726 0.617
Loa Loa (eye worm) hypothetical protein 0.0073 0.071 0.071
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0137 0.0297
Brugia malayi hypothetical protein 0.0072 0.0699 0.0699
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0637 0.7167 0.7167
Echinococcus multilocularis Glycoside hydrolase, family 27 0.011 0.1139 0.1262
Echinococcus multilocularis neuropeptides capa receptor 0.0637 0.7167 0.7959
Echinococcus multilocularis neuropeptide receptor 0.0637 0.7167 0.7959
Brugia malayi Protein kinase domain containing protein 0.0244 0.2673 0.2673
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0308 0.0425
Brugia malayi steroid hormone receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0034 0.0034
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0542 0.842
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0003

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Elevation of IFNgamma in C57B/6 mouse at 1 ug, iv ChEMBL. 17266209
Activity (functional) Elevation of IL4 in C57B/6 mouse at 1 ug, iv ChEMBL. 17266209
Activity (functional) 0 Elevation of IL4 in C57B/6 mouse at 1 ug, iv ChEMBL. 17266209
Activity (functional) 0 Elevation of IFNgamma in C57B/6 mouse at 1 ug, iv ChEMBL. 17266209
Activity (functional) 0 Stimualtion of IL2 production in DN32.D3 cells after 16 hrs ChEMBL. 17266209

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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