Detailed information for compound 41567

Basic information

Technical information
  • TDR Targets ID: 41567
  • Name: 2-(hexadecylamino)pyrimidine-5-carboxylic aci d
  • MW: 363.537 | Formula: C21H37N3O2
  • H donors: 2 H acceptors: 4 LogP: 7.8 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCCCNc1ncc(cn1)C(=O)O
  • InChi: 1S/C21H37N3O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-22-21-23-17-19(18-24-21)20(25)26/h17-18H,2-16H2,1H3,(H,25,26)(H,22,23,24)
  • InChiKey: VMBXUQXVTQTXOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(hexadecylamino)-5-pyrimidinecarboxylic acid
  • 2-(cetylamino)pyrimidine-5-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0504 0.0904
Echinococcus multilocularis BRK domain containing protein 0.0012 0.006 0.006
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0728 0.0728
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0038 0.0321
Trypanosoma brucei ribosomal RNA processing protein 6 0.0009 0.0018 0.0148
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0104 0.1185 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.1191 0.2139
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0099 0.0099
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0076 0.0842 0.0842
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0038 0.1779
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0099 0.0797
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0025 0.0025
Schistosoma mansoni flap endonuclease-1 0.0049 0.0515 0.0515
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0036 0.0349 0.0349
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.2976 0.5344
Brugia malayi MH2 domain containing protein 0.0008 0.0004 0.0008
Schistosoma mansoni hypothetical protein 0.0015 0.01 0.01
Echinococcus granulosus FTZ F1 alpha 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0137 0.0247
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0096 0.0172
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0214 0.1722
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.129 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0842 0.9082
Leishmania major hypothetical protein, conserved 0.0011 0.0047 0.0378
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0375 0.0375
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0728 0.1307
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0109 0.1242 1
Brugia malayi topoisomerase 0.001 0.0038 0.0068
Echinococcus multilocularis global transcription activator snf2l2 0.007 0.0769 0.0769
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0099 0.1068
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.02 0.161
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0031 0.0031
Echinococcus granulosus dna polymerase kappa 0.0104 0.1185 0.1185
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0529 0.4255
Entamoeba histolytica hypothetical protein 0.0038 0.0375 0.0425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0031 0.0056
Loa Loa (eye worm) BRM protein 0.0045 0.0459 0.0824
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0025 0.0025
Echinococcus multilocularis PWWP domain containing protein 2A 0.001 0.0034 0.0034
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.052 0.052
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0236 0.1901
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0009 0.0015 0.0166
Leishmania major DNA damage repair protein, putative 0.0024 0.02 0.161
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0151 0.2441
Schistosoma mansoni SET domain protein 0.0016 0.0104 0.0104
Entamoeba histolytica DNA-repair protein, putative 0.0011 0.0047 0.0053
Loa Loa (eye worm) Smad1 0.0017 0.012 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0047 0.0378
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0099 0.0178
Giardia lamblia DNA damage repair protein 0.0024 0.02 0.0184
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0083 0.0927 0.7464
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0384
Mycobacterium ulcerans hypothetical protein 0.0009 0.0018 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0031 0.0056
Echinococcus granulosus neuropeptide s receptor 0.0483 0.5817 0.5817
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0099 0.0099
Echinococcus granulosus lamin dm0 0.0028 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0044
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0038 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0034 0.0272
Echinococcus multilocularis exonuclease 1 0.0011 0.0047 0.0047
Loa Loa (eye worm) flap endonuclease-1 0.0055 0.058 0.1041
Brugia malayi hypothetical protein 0.001 0.0038 0.0068
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1118 0.8998
Trypanosoma brucei unspecified product 0.0053 0.0553 0.4453
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.0067 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0031 0.0056
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0076 0.0842 0.0842
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0504 0.0904
Loa Loa (eye worm) PWWP domain-containing protein 0.001 0.0034 0.0061
Echinococcus multilocularis muscleblind protein 1 0.0301 0.3596 0.3596
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0165 0.1926 0.1926
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.02 0.218
Brugia malayi hypothetical protein 0.001 0.0034 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0235 0.0422
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.0056
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0025 0.0044
Entamoeba histolytica recQ family helicase, putative 0.0058 0.0622 0.0704
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0027 0.0027
Echinococcus granulosus tar DNA binding protein 0.0067 0.0728 0.0728
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0214 1
Echinococcus multilocularis GPCR, family 2 0.0048 0.0504 0.0504
Schistosoma mansoni hypothetical protein 0.001 0.0034 0.0034
Brugia malayi Temporarily assigned gene name protein 44 0.0026 0.0235 0.0422
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0137 0.1482
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0057 0.0608 0.4713
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0038 0.0306
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0025 0.022 0.0396
Brugia malayi CXXC zinc finger family protein 0.0058 0.0619 0.1112
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.022 0.1709
Echinococcus multilocularis nibrin 0.001 0.0038 0.0038
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0375 0.0375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1039 0.1039
Schistosoma mansoni smad1 5 8 and 0.0017 0.012 0.012
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.012 0.012
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.236 0.236
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0072 0.0604
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0009 0.0018 0.0198
Loa Loa (eye worm) RNA binding protein 0.0067 0.0728 0.1307
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0025 0.0025
Schistosoma mansoni blooms syndrome DNA helicase 0.0066 0.0712 0.0712
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0015 0.0245
Onchocerca volvulus 0.001 0.0038 0.0068
Schistosoma mansoni hypothetical protein 0.0026 0.0235 0.0235
Echinococcus granulosus PWWP domain containing protein 2A 0.001 0.0034 0.0034
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0214 0.1805
Trypanosoma brucei unspecified product 0.0053 0.0553 0.4453
Brugia malayi hypothetical protein 0.0017 0.0121 0.0217
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.005 0.0518 0.0518
Toxoplasma gondii 3'-5' exonuclease domain-containing protein 0.0009 0.0018 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0031 0.0056
Echinococcus multilocularis Smad4 0.0017 0.012 0.012
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1118 0.1118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0137 0.0247
Schistosoma mansoni topbp1 0.001 0.0038 0.0038
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0137 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0137 0.0247
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0214 0.1805
Brugia malayi 3'-5' exonuclease family protein 0.0009 0.0018 0.0033
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0038 0.0614
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.02 0.1551
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0038 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.0056
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0038 0.0306
Schistosoma mansoni cpg binding protein 0.0061 0.066 0.066
Brugia malayi hypothetical protein 0.001 0.0034 0.0061
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0099 0.0797
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0728 0.1307
Onchocerca volvulus 0.0028 0.0256 0.0459
Entamoeba histolytica hypothetical protein 0.0208 0.245 0.2773
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0055 0.058 0.4493
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1118 0.2007
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.012 0.0215
Trichomonas vaginalis DNA helicase recq1, putative 0.0091 0.1022 0.8621
Schistosoma mansoni hepatoma derived growth factor 0.001 0.0034 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.012 0.012
Schistosoma mansoni blooms syndrome DNA helicase 0.0025 0.022 0.022
Brugia malayi hypothetical protein 0.0009 0.0025 0.0044
Brugia malayi Bloom's syndrome protein homolog 0.0091 0.1022 0.1835
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1118 0.2007
Echinococcus multilocularis geminin 0.0165 0.1926 0.1926
Echinococcus multilocularis PWWP domain containing protein 2A 0.001 0.0034 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1039 0.1039
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.005 0.0518 0.5648
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0031 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.1185 0.954
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0068
Schistosoma mansoni SET domain protein 0.0036 0.0349 0.0349
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0072 0.0604
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0137 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1039 0.1039
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1242 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.2035 0.3655
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0508 0.429
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0031 0.0056
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.022 0.1775
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0072 0.0604
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1242 1
Echinococcus granulosus Helicase RNase D C terminal HRDC domain 0.0009 0.0018 0.0018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0137 0.1159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0125 0.1348
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1185 0.954
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0236 0.1901
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0072 0.0604
Schistosoma mansoni DNA helicase recq5 0.005 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0028 0.0256 0.0459
Loa Loa (eye worm) hypothetical protein 0.0027 0.0236 0.0424
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.001 0.0034 0.0034
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0031 0.0031
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0236 0.1831
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0214 0.1805
Giardia lamblia Flap structure-specific endonuclease 0.0055 0.058 0.0616
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.0004 0.0008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0101 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0728 0.0728
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.005 0.0518 0.093
Loa Loa (eye worm) hypothetical protein 0.0014 0.0077 0.0139
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0605 0.0605
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0101 0.0101
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0038 0.0306
Echinococcus granulosus GPCR family 2 0.0048 0.0504 0.0504
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0099 0.0767
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.02 0.161
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0072 0.0604
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0125 0.1348
Schistosoma mansoni hypothetical protein 0.0048 0.0504 0.0504
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.012 0.012
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0025 0.0044
Brugia malayi nuclear hormone receptor 0.001 0.0031 0.0056
Schistosoma mansoni smad1 5 8 and 0.0017 0.012 0.012
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0004 0.0004
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0072 0.0604
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0072 0.0604
Schistosoma mansoni hypothetical protein 0.0012 0.006 0.006
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.005 0.0518 0.0518
Plasmodium falciparum DNA repair protein RAD2, putative 0.0011 0.0047 0.0512
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0047 0.0378
Trichomonas vaginalis DNA helicase recq, putative 0.0058 0.0622 0.5251
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0543 0.4371
Echinococcus granulosus polycomb protein SCMH1 0.005 0.052 0.052
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0038 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0508 0.429
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0384
Trypanosoma brucei transcription elongation factor s-II, putative 0.001 0.0034 0.0272
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0025 0.0025
Leishmania major DNA polymerase eta, putative 0.0103 0.1171 0.9424
Loa Loa (eye worm) runx1 0.0058 0.0621 0.1115
Leishmania major DNA polymerase kappa, putative 0.0024 0.02 0.161
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0072 0.0604
Echinococcus multilocularis muscleblind protein 0.0301 0.3596 0.3596
Loa Loa (eye worm) MBCTL1 0.0057 0.0605 0.1086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0099 0.0099
Entamoeba histolytica deoxycytidyl transferase, putative 0.0076 0.0842 0.0953
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1185 0.954
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0072 0.0604
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.005 0.0518 0.4016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0144 0.0144
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0038 0.0321
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0137 0.2216
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0038 0.0321
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0058 0.0622 0.501
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1118 0.8998
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0055 0.058 0.4666
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0099 0.0797
Echinococcus multilocularis Chromo domain 0.0012 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0031 0.0056
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0077 0.0077
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0011 0.0047 0.0047
Brugia malayi Muscleblind-like protein 0.0301 0.3596 0.6457
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0151 0.1632
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0151 0.0272
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.012 0.0215
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0058 0.0622 0.501
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0605 0.0605
Leishmania major hypothetical protein, conserved 0.001 0.0034 0.0272
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0214 0.1805
Echinococcus granulosus PWWP domain containing protein 2A 0.001 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Loa Loa (eye worm) 3'-5' exonuclease 0.0009 0.0018 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0125 0.1348
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0529 0.4097
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0068
Trypanosoma cruzi transcription elongation factor s-II, putative 0.001 0.0034 0.0272
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1242 1
Onchocerca volvulus 0.001 0.0034 0.0061
Schistosoma mansoni sex comb on midleg homolog 0.005 0.052 0.052
Brugia malayi RNA binding protein 0.0067 0.0728 0.1307
Trypanosoma brucei DNA repair protein RAD2, putative 0.0011 0.0047 0.0378
Echinococcus granulosus bloom syndrome protein 0.0091 0.1022 0.1022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1039 0.1039
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0142 0.0254
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0605 0.0605
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.052 0.052
Schistosoma mansoni hypothetical protein 0.0048 0.0504 0.0504
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0082 0.0917 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0031
Echinococcus multilocularis BRK domain containing protein 0.0012 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.0056
Trichomonas vaginalis flap endonuclease-1, putative 0.0055 0.058 0.4891
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1118 0.9431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0504 0.0504
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0083 0.0927 1
Brugia malayi XPG I-region family protein 0.0011 0.0047 0.0084
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0031 0.0056
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.022 0.1775
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0055 0.058 0.4666
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1118 0.9431
Echinococcus multilocularis musashi 0.0028 0.0256 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.0056
Entamoeba histolytica exonuclease, putative 0.0011 0.0047 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.02 0.161
Echinococcus multilocularis BRK domain containing protein 0.0012 0.006 0.006
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0236 0.381
Giardia lamblia DINP protein human, muc B family 0.0083 0.0927 0.1011
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.006 0.0107
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0025 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.1784 0.3203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.1185 0.954
Plasmodium vivax DEAD/DEAH helicase, putative 0.0011 0.0045 0.072
Schistosoma mansoni thyroid hormone receptor 0.001 0.0031 0.0031
Onchocerca volvulus 0.0025 0.0214 0.0384
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0099 0.0797
Schistosoma mansoni hypothetical protein 0.0038 0.0375 0.0375
Schistosoma mansoni hepatoma derived growth factor 0.001 0.0034 0.0034
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.001 0.0034 0.0272
Schistosoma mansoni Smad4 0.0017 0.012 0.012
Schistosoma mansoni DNA polymerase eta 0.0103 0.1171 0.1171
Loa Loa (eye worm) hypothetical protein 0.005 0.052 0.0934
Mycobacterium ulcerans hypothetical protein 0.0024 0.02 0.1688
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0214 0.1722
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0072 0.0604
Schistosoma mansoni phd finger protein 0.0012 0.0056 0.0056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0072 0.0604
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0101 0.0101
Echinococcus multilocularis dna polymerase eta 0.0103 0.1171 0.1171
Trichomonas vaginalis exonuclease%2C+putative 0.0011 0.0047 0.0396
Trypanosoma brucei calpain-like protein, putative 0.0109 0.1242 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0068
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0028 0.0249 0.0448
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.073 0.8835 1
Brugia malayi Flap endonuclease-1 0.0055 0.058 0.1041
Brugia malayi N-terminal motif family protein 0.0189 0.2217 0.3981
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.052 0.0934
Echinococcus granulosus hypothetical protein 0.0026 0.0235 0.0235
Brugia malayi hypothetical protein 0.0038 0.0375 0.0674
Schistosoma mansoni lamin 0.0028 0.0256 0.0256
Schistosoma mansoni hypothetical protein 0.0165 0.1926 0.1926
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1242 1
Echinococcus multilocularis neuropeptide receptor A26 0.0483 0.5817 0.5817
Treponema pallidum ATP-dependent DNA helicase 0.0025 0.022 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0105 0.1191 0.1191
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0031 0.0056
Plasmodium vivax DNA repair protein RAD2, putative 0.0011 0.0047 0.0757
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.0004 0.0008
Echinococcus granulosus global transcription activator snf2l2 0.007 0.0769 0.0769
Echinococcus granulosus Chromo domain 0.0012 0.006 0.006
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0072 0.0604
Brugia malayi MH2 domain containing protein 0.0017 0.012 0.0215
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0077 0.0077
Trichomonas vaginalis lymphoid specific helicase, putative 0.0013 0.0067 0.0568
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0214 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1118 0.9431
Plasmodium falciparum flap endonuclease 1 0.0055 0.058 0.6317
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0072 0.0604
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0151 0.1277
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0068
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0031 0.0031
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0605 0.1086
Echinococcus multilocularis flap endonuclease 1 0.0055 0.058 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1185 0.954
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0256 0.0459
Echinococcus multilocularis peregrin 0.0012 0.0056 0.0056
Brugia malayi intermediate filament protein 0.0028 0.0256 0.0459
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0058 0.062 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0031 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0025 0.0025
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0047 0.0396
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0038 0.0068
Loa Loa (eye worm) hypothetical protein 0.0103 0.1171 0.2102
Schistosoma mansoni kinase 0.005 0.0524 0.0524
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0047 0.0364
Schistosoma mansoni smad 0.0017 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.02 0.02
Echinococcus multilocularis microtubule associated protein 2 0.0721 0.8725 0.8725
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0214 0.0242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0044
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1118 0.1118
Brugia malayi hypothetical protein 0.0026 0.0235 0.0422
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0012 0.0063 0.0063
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0076 0.0842 0.0842
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0031 0.0031
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0151 0.1277
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1242 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0031 0.0056
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0109 0.1242 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0605 0.1086
Trypanosoma brucei unspecified product 0.0097 0.11 0.8855
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0015 0.0128
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0031 0.0031
Echinococcus multilocularis BRK domain containing protein 0.0012 0.006 0.006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0031 0.0031
Echinococcus multilocularis hepatoma derived growth factor protein 0.001 0.0034 0.0034
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0031 0.0031
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0025 0.0025
Echinococcus granulosus cpg binding protein 0.0061 0.066 0.066
Trypanosoma brucei hypothetical protein 0.0109 0.1242 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0101 0.0101
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0045 0.0346
Leishmania major DNA polymerase kappa, putative 0.0083 0.0927 0.7464
Leishmania major exosome subunit rrp6p homologue, putative 0.0009 0.0018 0.0148
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0047 0.0396
Brugia malayi polk-prov protein 0.0052 0.0543 0.0975
Echinococcus granulosus peregrin 0.0012 0.0056 0.0056
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0047 0.0364
Brugia malayi tumor suppressor. 0.0313 0.3736 0.6709
Echinococcus granulosus nibrin 0.001 0.0038 0.0038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0031 0.0031
Mycobacterium leprae conserved hypothetical protein 0.0009 0.0018 0.086
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0047 0.0364
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0728 0.0728
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0031 0.0031
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0057 0.0057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0125 0.1348
Toxoplasma gondii hypothetical protein 0.0009 0.0025 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1185 0.954
Brugia malayi MH2 domain containing protein 0.0251 0.2976 0.5344
Echinococcus multilocularis lamin dm0 0.0028 0.0256 0.0256
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0038 0.0321
Onchocerca volvulus 0.0028 0.0256 0.0459
Schistosoma mansoni thyroid hormone receptor 0.001 0.0031 0.0031
Schistosoma mansoni smad 0.0008 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0072 0.0604
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0025 0.0025
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0099 0.0099
Brugia malayi steroid hormone receptor 0.001 0.0031 0.0056
Schistosoma mansoni hypothetical protein 0.0048 0.0504 0.0504
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.001 0.0034 0.0272
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.236 0.236
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1242 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0025 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0151 0.1218
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.0128
Trypanosoma brucei DNA polymerase eta, putative 0.0103 0.1171 0.9424
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0728 0.0728
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0151 0.1218
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0543 0.4371
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0214 0.2307
Plasmodium vivax flap endonuclease 1, putative 0.0055 0.058 0.9351
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0057 0.0057
Brugia malayi MH1 domain containing protein 0.0009 0.0027 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0031 0.0056
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.052 0.052
Schistosoma mansoni terminal deoxycytidyl transferase 0.0076 0.0842 0.0842
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0031
Schistosoma mansoni microtubule-associated protein tau 0.0721 0.8725 0.8725
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0096 0.0172
Schistosoma mansoni sex comb on midleg homolog 0.005 0.052 0.052
Giardia lamblia DNA repair protein RAD52 0.073 0.8835 1
Trichomonas vaginalis helicase, putative 0.0013 0.0072 0.0604
Trypanosoma cruzi ribosomal RNA processing protein 6, putative 0.0009 0.0018 0.0148
Echinococcus multilocularis bloom syndrome protein 0.0091 0.1022 0.1022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1242 1
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0209 0.0236
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.11 0.8855
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0214 0.0242
Echinococcus granulosus smad 0.0017 0.012 0.012
Brugia malayi PWWP domain containing protein 0.001 0.0034 0.0061
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.2217 0.3981
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0101 0.0101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0031 0.0056
Echinococcus multilocularis BRK domain containing protein 0.0012 0.006 0.006
Loa Loa (eye worm) nuclear factor I 0.0009 0.0027 0.0048
Echinococcus granulosus Smad4 0.0017 0.012 0.012
Schistosoma mansoni hypothetical protein 0.001 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1185 0.954
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0099 0.1597
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1118 0.9431
Echinococcus multilocularis lamin 0.0028 0.0256 0.0256
Echinococcus granulosus muscleblind protein 0.0301 0.3596 0.3596
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.2976 0.5344
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0619 0.1112
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0151 0.6207
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.02 0.161
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0109 0.1242 1
Loa Loa (eye worm) helicase DNA-binding protein 0.0012 0.006 0.0107
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1118 0.1265
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0236 0.2574
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0099 0.0099
Echinococcus granulosus exonuclease 1 0.0011 0.0047 0.0047
Echinococcus granulosus protein quaking 0.0026 0.0235 0.0235
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0031 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0038 0.0306
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.02 0.3227
Entamoeba histolytica recQ family DNA helicase 0.0025 0.022 0.025
Entamoeba histolytica exonuclease, putative 0.0011 0.0047 0.0053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0018 0.0155
Echinococcus granulosus microtubule associated protein 2 0.0721 0.8725 0.8725
Echinococcus multilocularis dna polymerase kappa 0.0104 0.1185 0.1185
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0099 0.0099
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0504 0.0504
Onchocerca volvulus 0.001 0.0031 0.0056
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0151 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0099 0.0797
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0031 0.0031
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0144 0.0144
Schistosoma mansoni DNA helicase recq1 0.005 0.0518 0.0518
Schistosoma mansoni dep domain containing protein 0.0009 0.0025 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.0842 0.1512
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0463 0.5568 1
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0011 0.0047 0.0047
Plasmodium vivax exosome complex exonuclease RRP6, putative 0.0009 0.0018 0.0297
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0047 0.0364
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0038 0.0321
Giardia lamblia Exonuclease 1 0.0011 0.0047 0.001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0076 0.0842 0.1512
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0109 0.1242 1
Trypanosoma brucei calpain, putative 0.0109 0.1242 1
Schistosoma mansoni cpg binding protein 0.0061 0.066 0.066
Giardia lamblia hypothetical protein 0.0011 0.0047 0.001
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0099 0.0767
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0031 0.0056
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0011 0.0047 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0638 0.5138
Schistosoma mansoni ap endonuclease 0.002 0.0151 0.0151
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0011 0.0047 0.0047
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0024 0.0209 0.3368
Entamoeba histolytica hypothetical protein 0.001 0.0038 0.0043
Brugia malayi MH1 domain containing protein 0.0017 0.012 0.0215
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0214 0.1722
Echinococcus multilocularis flap endonuclease GEN 1 0.0011 0.0047 0.0047
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0728 0.1307
Loa Loa (eye worm) hypothetical protein 0.0301 0.3596 0.6457
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.1185 0.954
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1185 0.954
Leishmania major hypothetical protein, conserved 0.0027 0.0236 0.1901
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.02 0.161
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1185 0.954
Entamoeba histolytica hypothetical protein 0.0038 0.0375 0.0425
Loa Loa (eye worm) hypothetical protein 0.0463 0.5568 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0214 0.0384
Brugia malayi BRM protein 0.007 0.0769 0.1381
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.1185 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0038 0.0295
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0099 0.0099
Schistosoma mansoni cpg binding protein 0.0058 0.0619 0.0619
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0504 0.0504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1039 0.1867
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0236 0.2574
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1039 0.1039
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0214 0.0384
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0151 0.1218
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0055 0.058 0.4666
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.1185 0.954
Loa Loa (eye worm) hypothetical protein 0.0153 0.1784 0.3203
Mycobacterium ulcerans ATP-dependent DNA helicase II UvrD2 0.0009 0.0015 0.0128
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0025 0.0025
Brugia malayi mbt repeat family protein 0.005 0.052 0.0934
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0031
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.052 0.052
Brugia malayi TAR-binding protein 0.0067 0.0728 0.1307
Echinococcus multilocularis Helicase RNase D C terminal, HRDC domain 0.0009 0.0018 0.0018
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0605 0.0605
Brugia malayi hypothetical protein 0.001 0.0038 0.0068
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0058 0.0622 0.501
Brugia malayi hypothetical protein 0.0027 0.0236 0.0424
Entamoeba histolytica hypothetical protein 0.0038 0.0375 0.0425
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0038 0.0321
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1118 0.9431
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0038 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1185 0.954
Brugia malayi hypothetical protein 0.0009 0.0025 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0638 0.5138
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0025 0.0044
Entamoeba histolytica exosome component 10, putative 0.0009 0.0018 0.0021
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1118 0.8998
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0214 0.1805
Schistosoma mansoni hypothetical protein 0.0026 0.0235 0.0235
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0004 0.0008
Schistosoma mansoni DNA ligase IV 0.001 0.0038 0.0038
Mycobacterium tuberculosis Probable ATP-dependent DNA helicase II UvrD2 0.0009 0.0015 0.0164
Trichomonas vaginalis DNA helicase recq, putative 0.0091 0.1022 0.8621
Echinococcus granulosus flap endonuclease GEN 1 0.0011 0.0047 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1118 0.9431
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0047 0.0396
Echinococcus multilocularis Protein lozenge 0.0058 0.0621 0.0621
Echinococcus multilocularis cpg binding protein 0.0061 0.066 0.066
Brugia malayi mbt repeat family protein 0.005 0.052 0.0934
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.02 0.161
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0072 0.0604
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0728 0.0728
Echinococcus multilocularis protein quaking 0.0026 0.0235 0.0235
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1242 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0543 0.0975
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0038 0.0321
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0504 0.0904
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.1784 0.3203
Trichomonas vaginalis DNA polymerase eta, putative 0.0104 0.1185 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.1185 0.954
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0038 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0638 0.5138
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0099 0.1079
Brugia malayi ImpB/MucB/SamB family protein 0.0103 0.1171 0.2102
Echinococcus granulosus replication factor c subunit 1 0.001 0.0038 0.0038
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.1185 1
Loa Loa (eye worm) tumor suppressor 0.0313 0.3736 0.6709
Echinococcus granulosus neuropeptide receptor A26 0.0483 0.5817 0.5817
Echinococcus granulosus geminin 0.0165 0.1926 0.1926
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1118 0.9431
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0151 0.1218
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0927 0.7464
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0214 0.2307
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1039 0.1867
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0031 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0031 0.0031
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.005 0.0518 0.093
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0256 0.0459
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.1784 0.3203
Leishmania major DNA polymerase eta, putative 0.0051 0.0529 0.4255
Onchocerca volvulus 0.0058 0.0619 0.1112
Schistosoma mansoni lamin 0.0028 0.0256 0.0256
Echinococcus multilocularis BRK domain 0.0012 0.006 0.006
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.02 0.161
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1242 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0031 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0144 0.0259
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0825 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0031 0.0056
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0072 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1185 0.954
Brugia malayi MH2 domain containing protein 0.0017 0.012 0.0215
Toxoplasma gondii hypothetical protein 0.001 0.0034 0.0262
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0605 0.0605
Schistosoma mansoni helicase 0.007 0.0769 0.0769
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0151 0.1277
Brugia malayi DIX domain containing protein 0.0009 0.0025 0.0044
Loa Loa (eye worm) hypothetical protein 0.005 0.0518 0.093
Toxoplasma gondii exonuclease III APE 0.002 0.0151 0.1173
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0214 0.1805
Schistosoma mansoni hypothetical protein 0.0048 0.0504 0.0504
Trypanosoma brucei polo-like protein kinase 0.0099 0.1118 0.8998
Echinococcus granulosus lamin 0.0028 0.0256 0.0256
Onchocerca volvulus 0.001 0.0034 0.0061
Loa Loa (eye worm) hypothetical protein 0.0301 0.3596 0.6457
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0012 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0009 0.0027 0.0048
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0036 0.0349 0.0349
Loa Loa (eye worm) mbt repeat family protein 0.005 0.052 0.0934
Echinococcus multilocularis BRK domain containing protein 0.0012 0.006 0.006
Echinococcus granulosus flap endonuclease 1 0.0055 0.058 0.058
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0099 0.0178
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0038 0.0043
Loa Loa (eye worm) RecQ helicase 0.0091 0.1022 0.1835
Onchocerca volvulus 0.005 0.052 0.0934
Brugia malayi DKFZp564C0469 protein 0.001 0.0038 0.0068
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0208 0.245 0.2773
Entamoeba histolytica hypothetical protein 0.001 0.0034 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0038 0.0321
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0214 0.0384
Schistosoma mansoni exonuclease 0.0011 0.0047 0.0047
Echinococcus multilocularis neuropeptide s receptor 0.0483 0.5817 0.5817
Echinococcus granulosus ATP dependent DNA helicase Q5 0.005 0.0518 0.0518
Entamoeba histolytica hypothetical protein 0.0038 0.0375 0.0425
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0025 0.0044
Plasmodium vivax exonuclease I, putative 0.0011 0.0047 0.0757
Trypanosoma brucei exonuclease, putative 0.0011 0.0047 0.0378
Giardia lamblia Sgs1 DNA helicase, putative 0.005 0.0518 0.0546
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0047 0.0396
Schistosoma mansoni intermediate filament proteins 0.0028 0.0256 0.0256
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0031 0.0056
Entamoeba histolytica Flap nuclease, putative 0.0055 0.058 0.0656
Schistosoma mansoni nuclear hormone receptor 0.001 0.0031 0.0031
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0047 0.0378
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0038 0.0038
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0038 0.0321
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0025 0.0044
Plasmodium falciparum exonuclease I, putative 0.0011 0.0047 0.0512
Schistosoma mansoni dishevelled 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Echinococcus granulosus intermediate filament protein 0.0028 0.0256 0.0256
Loa Loa (eye worm) BRM protein 0.0036 0.0355 0.0637
Brugia malayi MH1 domain containing protein 0.0009 0.0027 0.0048
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0151 0.0171
Schistosoma mansoni topbp1 0.001 0.0038 0.0038
Schistosoma mansoni Smad4 0.0008 0.0004 0.0004
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.02 0.161
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0034 0.0272
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0137 0.1497
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0151 0.0129
Brugia malayi Smad1 0.0017 0.012 0.0215
Loa Loa (eye worm) hypothetical protein 0.0189 0.2217 0.3981
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1428 0.1428
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.0056
Mycobacterium ulcerans hypothetical protein 0.0025 0.0214 0.1805
Schistosoma mansoni hypothetical protein 0.0012 0.0057 0.0057
Echinococcus granulosus ATP dependent DNA helicase Q1 0.005 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.006 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1039 0.1039
Echinococcus granulosus dna polymerase eta 0.0103 0.1171 0.1171
Trypanosoma cruzi DNA polymerase eta, putative 0.0103 0.1171 0.9424
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1118 0.2007
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.1191 0.2139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0137 0.0247
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0031 0.0031
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0011 0.0045 0.0486
Brugia malayi nuclear receptor NHR-88 0.001 0.0031 0.0056
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0151 0.1649
Onchocerca volvulus 0.0009 0.0025 0.0044
Schistosoma mansoni ap endonuclease 0.002 0.0151 0.0151
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0031 0.0056
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0109 0.1242 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0151 0.0151
Schistosoma mansoni coup transcription factor 0.001 0.0031 0.0031
Echinococcus multilocularis dnaJ subfamily B 0.0825 1 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0038 0.0321
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.1185 0.954
Brugia malayi MH1 domain containing protein 0.0017 0.012 0.0215
Echinococcus granulosus BRK domain containing protein 0.0012 0.006 0.006
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0031 0.0285 0.221
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0504 0.0504
Loa Loa (eye worm) ATP-dependent DNA helicase 0.005 0.0518 0.093
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.02 0.161
Schistosoma mansoni lozenge 0.0058 0.0621 0.0621
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.005 0.0518 0.4016
Onchocerca volvulus 0.0463 0.5568 1
Echinococcus multilocularis smad 0.0017 0.012 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0031 0.0056
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0236 0.1901
Loa Loa (eye worm) XPG I-region family protein 0.0011 0.0047 0.0084
Schistosoma mansoni smad1 5 8 and 0.0017 0.012 0.012
Echinococcus granulosus hepatoma derived growth factor protein 0.001 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0048 0.0504 0.0904
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1242 1
Schistosoma mansoni Smad4 0.0008 0.0004 0.0004
Brugia malayi hypothetical protein 0.0463 0.5568 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0047 0.0378
Brugia malayi isocitrate dehydrogenase 0.0015 0.0099 0.0178
Schistosoma mansoni dishevelled 0.0009 0.0025 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0375 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0072 0.0604
Schistosoma mansoni hypothetical protein 0.0307 0.3663 0.3663
Giardia lamblia Kinase, PLK 0.0099 0.1118 0.1227
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0214 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0151 0.0272
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0256 0.0459
Brugia malayi ecdysteroid receptor 0.001 0.0031 0.0056
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0214 0.1805
Schistosoma mansoni polymyositis/scleroderma autoantigen-related 0.0009 0.0018 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0031 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1118 0.1118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1039 0.1039

Activities

Activity type Activity value Assay description Source Reference
Diet (functional) = 89 % In vivo triglyceride lowering activity when dosed as 0.01 % of the diet ChEMBL. 6604817
Diet (functional) = 93 % In vivo triglyceride lowering activity dosed at 0.10 % of the diet. ChEMBL. 6604817
Diet (functional) = 94 % In vivo triglyceride lowering activity when dosed at 0.03 % of the diet ChEMBL. 6604817
Diet (functional) = 108 % In vivo sterol lowering activity when dosed as 0.03 % of the diet ChEMBL. 6604817
Diet (functional) = 108 % In vivo sterol lowering activity when dosed as 0.01 % of the diet ChEMBL. 6604817
Diet (functional) = 114 % In vivo sterol lowering activity at dose of 0.10 % of the diet ChEMBL. 6604817
Inhibition (binding) < 21 % In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase ChEMBL. 6604817
Inhibition (binding) < 21 % In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase ChEMBL. 6604817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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