Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0038 | 0.0105 | 0.0357 |
Echinococcus multilocularis | tar DNA binding protein | 0.0055 | 0.0204 | 0.0444 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.0475 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0764 | 0.4412 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0073 | 0.0316 | 0.0697 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0038 | 0.0105 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0764 | 0.4412 | 1 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.0475 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0038 | 0.0105 | 0.0357 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.01 | 0.0475 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0085 | 0.0382 | 0.0442 |
Leishmania major | protein phosphatase 2A regulatory subunit, putative | 0.003 | 0.0059 | 0.125 |
Brugia malayi | TAR-binding protein | 0.0055 | 0.0204 | 0.0444 |
Entamoeba histolytica | protein phosphatase regulatory subunit, putative | 0.0022 | 0.0009 | 0.1498 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.01 | 0.0475 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0038 | 0.0105 | 0.0357 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0038 | 0.0105 | 0.2216 |
Trypanosoma brucei | hypothetical protein, conserved | 0.003 | 0.0059 | 0.1083 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0764 | 0.4412 | 0.521 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0764 | 0.4412 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0764 | 0.4412 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0055 | 0.0204 | 0.0444 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0025 | 0.0028 | 0.0019 |
Brugia malayi | DOMON domain containing protein | 0.0146 | 0.0748 | 0.1679 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0025 | 0.0028 | 0.0043 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0036 | 0.0092 | 0.0098 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0038 | 0.0105 | 0.2216 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0764 | 0.4412 | 0.521 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0038 | 0.0105 | 0.0357 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0038 | 0.0105 | 0.0357 |
Loa Loa (eye worm) | RNA binding protein | 0.0055 | 0.0204 | 0.0444 |
Brugia malayi | Importin beta-1 subunit | 0.0025 | 0.0028 | 0.0043 |
Plasmodium falciparum | importin beta, putative | 0.0025 | 0.0028 | 0.0408 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.0475 | 1 |
Trypanosoma cruzi | protein phosphatase 2A, regulatory subunit B, putative | 0.0022 | 0.0009 | 0.0187 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0038 | 0.0105 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0038 | 0.0105 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0038 | 0.0105 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0065 | 0.0269 | 0.462 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0036 | 0.0092 | 0.2653 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0.0059 | 0.125 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0038 | 0.0105 | 0.0357 |
Onchocerca volvulus | 0.0146 | 0.0748 | 1 | |
Plasmodium vivax | importin-beta 2, putative | 0.0025 | 0.0028 | 0.0408 |
Brugia malayi | DOMON domain containing protein | 0.0146 | 0.0748 | 0.1679 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0036 | 0.0092 | 0.1927 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.01 | 0.0475 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0388 | 0.218 | 0.4931 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0146 | 0.0748 | 0.1679 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0073 | 0.0316 | 0.0697 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0043 | 0.0136 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0028 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0316 | 0.0363 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0146 | 0.0748 | 0.1679 |
Trypanosoma cruzi | protein phosphatase 2A regulatory subunit, putative | 0.003 | 0.0059 | 0.125 |
Brugia malayi | Cytochrome P450 family protein | 0.0049 | 0.0172 | 0.0369 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.0475 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0043 | 0.0136 | 0.2857 |
Trypanosoma brucei | protein phosphatase 2A regulatory subunit, putative | 0.003 | 0.0059 | 0.1083 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0085 | 0.0382 | 0.0848 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0146 | 0.0748 | 0.1679 |
Brugia malayi | DOMON domain containing protein | 0.0146 | 0.0748 | 0.1679 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0055 | 0.0204 | 0.0444 |
Trypanosoma cruzi | protein phosphatase 2A regulatory subunit, putative | 0.003 | 0.0059 | 0.125 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.1447 | 0.8461 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0.0059 | 0.125 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0033 | 0.0077 | 0.1629 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0036 | 0.0092 | 0.0188 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0038 | 0.0105 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0764 | 0.4412 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0055 | 0.0204 | 0.0231 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0049 | 0.0172 | 0.0369 |
Schistosoma mansoni | tar DNA-binding protein | 0.0055 | 0.0204 | 0.0231 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0038 | 0.0105 | 0.0219 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0043 | 0.0136 | 0.0288 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0105 | 0.0114 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0043 | 0.0136 | 0.2857 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0038 | 0.0105 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0038 | 0.0105 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0059 | 0.125 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.0475 | 0.0551 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0038 | 0.0105 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0038 | 0.0105 | 1 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0038 | 0.0105 | 0.2216 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.01 | 0.0475 | 0.1058 |
Echinococcus multilocularis | 0.0038 | 0.0105 | 0.0219 | |
Leishmania major | cytochrome p450-like protein | 0.0038 | 0.0105 | 0.2216 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0038 | 0.0105 | 0.0357 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0043 | 0.0136 | 0.0288 |
Schistosoma mansoni | thyroid hormone receptor | 0.0085 | 0.0382 | 0.0442 |
Trypanosoma cruzi | protein phosphatase 2A, regulatory subunit B, putative | 0.0022 | 0.0009 | 0.0187 |
Echinococcus granulosus | importin subunit beta 1 | 0.0025 | 0.0028 | 0.0043 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.01 | 0.0475 | 0.1058 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0038 | 0.0105 | 0.0357 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0038 | 0.0105 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0038 | 0.0105 | 0.5 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0032 | 0.0072 | 0.1509 |
Trypanosoma brucei | cytochrome P450, putative | 0.0043 | 0.0136 | 0.2721 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0036 | 0.0092 | 0.0083 |
Schistosoma mansoni | cytochrome P450 | 0.0038 | 0.0105 | 0.0114 |
Leishmania major | protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative | 0.0022 | 0.0009 | 0.0187 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0043 | 0.0136 | 0.1152 |
Echinococcus granulosus | protein phosphatase pp2a regulatory subunit b | 0.003 | 0.0059 | 0.0115 |
Schistosoma mansoni | tar DNA-binding protein | 0.0055 | 0.0204 | 0.0231 |
Mycobacterium leprae | putative cytochrome p450 | 0.0038 | 0.0105 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.01 | 0.0475 | 1 |
Trichomonas vaginalis | phosphotyrosyl phosphatase activator, putative | 0.0022 | 0.0009 | 0.0187 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0038 | 0.0105 | 0.0357 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0065 | 0.0269 | 0.026 |
Echinococcus granulosus | snurportin 1 | 0.0265 | 0.1455 | 0.3285 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0036 | 0.0092 | 0.0188 |
Loa Loa (eye worm) | TAR-binding protein | 0.0055 | 0.0204 | 0.0444 |
Echinococcus multilocularis | protein phosphatase pp2a regulatory subunit b | 0.003 | 0.0059 | 0.0115 |
Onchocerca volvulus | 0.0146 | 0.0748 | 1 | |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0038 | 0.0105 | 0.0357 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0038 | 0.0105 | 0.0357 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0764 | 0.4412 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0043 | 0.0136 | 0.0288 |
Echinococcus granulosus | tar DNA binding protein | 0.0055 | 0.0204 | 0.0444 |
Brugia malayi | RNA, U transporter 1 | 0.0071 | 0.03 | 0.0661 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.01 | 0.0475 | 0.1058 |
Giardia lamblia | Protein phosphatase PP2A regulatory subunit B | 0.003 | 0.0059 | 0.1083 |
Loa Loa (eye worm) | cytochrome P450 | 0.0038 | 0.0105 | 0.0219 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0036 | 0.0092 | 0.0098 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0038 | 0.0105 | 1 |
Onchocerca volvulus | Protein phosphatase PP2A 55 kDa regulatory subunit homolog | 0.003 | 0.0059 | 0.0682 |
Brugia malayi | Cytochrome P450 family protein | 0.0043 | 0.0136 | 0.0288 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.01 | 0.0475 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0038 | 0.0105 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0038 | 0.0105 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0038 | 0.0105 | 0.0357 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0025 | 0.0028 | 0.0408 |
Trichomonas vaginalis | protein phosphatase PP2A regulatory subunit B, putative | 0.003 | 0.0059 | 0.125 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0038 | 0.0105 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0376 | 0.2112 | 0.4777 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0038 | 0.0105 | 1 |
Brugia malayi | serine/threonine protein phosphatase 2A | 0.003 | 0.0059 | 0.0115 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0038 | 0.0105 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0038 | 0.0105 | 0.2216 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0038 | 0.0105 | 0.0357 |
Schistosoma mansoni | tar DNA-binding protein | 0.0055 | 0.0204 | 0.0231 |
Schistosoma mansoni | importin beta-1 | 0.0025 | 0.0028 | 0.0022 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0038 | 0.0105 | 1 |
Trichomonas vaginalis | serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative | 0.003 | 0.0059 | 0.125 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.01 | 0.0475 | 0.1058 |
Entamoeba histolytica | protein phosphatase regulatory subunit, putative | 0.003 | 0.0059 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0038 | 0.0105 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0038 | 0.0105 | 0.2067 |
Loa Loa (eye worm) | serine/threonine protein phosphatase 2A | 0.003 | 0.0059 | 0.0115 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.01 | 0.0475 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0038 | 0.0105 | 0.0219 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0038 | 0.0105 | 0.0357 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0025 | 0.0028 | 0.0408 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0038 | 0.0105 | 0.0357 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.0475 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0265 | 0.1455 | 0.3285 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0038 | 0.0105 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0265 | 0.1455 | 0.3285 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0038 | 0.0105 | 0.0357 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.0475 | 0.0466 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0038 | 0.0105 | 0.0357 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0038 | 0.0105 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.01 | 0.0475 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0038 | 0.0105 | 0.2216 |
Brugia malayi | RNA binding protein | 0.0055 | 0.0204 | 0.0444 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0038 | 0.0105 | 1 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0038 | 0.0105 | 0.0357 |
Schistosoma mansoni | hypothetical protein | 0.0265 | 0.1455 | 0.1711 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0038 | 0.0105 | 0.0357 |
Brugia malayi | cytochrome P450 | 0.0038 | 0.0105 | 0.0219 |
Schistosoma mansoni | protein phosphatase pp2a regulatory subunit B | 0.003 | 0.0059 | 0.006 |
Trichomonas vaginalis | protein phosphatase pp2a regulatory subunit B, putative | 0.003 | 0.0059 | 0.125 |
Schistosoma mansoni | tar DNA-binding protein | 0.0055 | 0.0204 | 0.0231 |
Brugia malayi | Cytochrome P450 family protein | 0.0043 | 0.0136 | 0.0288 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 200 uM | Cytotoxicity against mouse L1210/0 cells after 48 hrs | ChEMBL. | 17341060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.