Detailed information for compound 505604

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1646.68 | Formula: C77H91N13O26S
  • H donors: 16 H acceptors: 23 LogP: 0.9 Rotable bonds: 45
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC(=O)CC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCCCC1C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCC(=O)O)CCC(=O)O)O/N=C\c1ccc(c(c1)C(=O)O)O)C)[C@H](O)C)NC(=O)[C@@H]1CCCN1C(=O)CCCCNC(=S)Nc1ccc2c(c1)C1(OC2=O)c2ccc(cc2Oc2c1ccc(c2)O)O
  • InChi: 1S/C77H91N13O26S/c1-38(71(108)89-28-6-4-9-55(89)73(110)90-37-44(116-80-36-40-13-23-57(94)46(31-40)74(111)112)35-56(90)69(106)84-51(21-25-62(98)99)66(103)83-50(65(78)102)20-24-61(96)97)81-70(107)64(39(2)91)86-68(105)54-11-8-30-88(54)72(109)52(22-26-63(100)101)85-67(104)53-10-7-29-87(53)60(95)12-3-5-27-79-76(117)82-41-14-17-45-49(32-41)77(115-75(45)113)47-18-15-42(92)33-58(47)114-59-34-43(93)16-19-48(59)77/h13-19,23,31-34,36,38-39,44,50-56,64,91-94H,3-12,20-22,24-30,35,37H2,1-2H3,(H2,78,102)(H,81,107)(H,83,103)(H,84,106)(H,85,104)(H,86,105)(H,96,97)(H,98,99)(H,100,101)(H,111,112)(H2,79,82,117)/b80-36-/t38-,39+,44+,50-,51-,52-,53-,54-,55?,56-,64-/m0/s1
  • InChiKey: LZLYQKCABTTYHA-WMBWYFCDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0415 0.041
Toxoplasma gondii aldehyde dehydrogenase 0.025 0.0899 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0124 0.0415 0.041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0025
Schistosoma mansoni nAChR subunit 0.0018 0.0007 0.0015
Echinococcus multilocularis neurogenic locus notch protein 0.0054 0.0147 0.0141
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.003 0.0025
Echinococcus granulosus bloom syndrome protein 0.0065 0.0188 0.0183
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0126 0.0377
Loa Loa (eye worm) hypothetical protein 0.0084 0.0262 0.0791
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0089 0.0083
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0085 0.008
Echinococcus granulosus intermediate filament protein 0.0083 0.0258 0.0252
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.015 0.0144
Entamoeba histolytica serine/threonine protein kinase, putative 0.009 0.0287 0.791
Toxoplasma gondii endonuclease IV APN 0.008 0.0248 0.2637
Entamoeba histolytica hypothetical protein 0.0038 0.0086 0.2154
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0059 0.0167 0.6564
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0153 0.1637
Onchocerca volvulus 0.0049 0.0126 0.0325
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0899 1
Mycobacterium ulcerans endonuclease IV 0.008 0.0248 0.2692
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Schistosoma mansoni nAChR subunit 0.0038 0.0085 0.0197
Onchocerca volvulus 0.0018 0.0007 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0287 0.0756
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0081 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0039 0.1077
Schistosoma mansoni metabotropic glutamate receptor 0.0046 0.0118 0.0272
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.01 0.0323 0.0317
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.0899 0.2077
Brugia malayi Protein kinase domain containing protein 0.0085 0.0267 0.0813
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.036 0.1092
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0063 0.0381
Brugia malayi Cache domain containing protein 0.0527 0.1965 0.6052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.086 0.3244 1
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.036 0.0831
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Echinococcus multilocularis musashi 0.0083 0.0258 0.0252
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.036 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0081 0.0075
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2037
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0085 0.008
Schistosoma mansoni thyroid hormone receptor 0.0292 0.1062 0.2453
Entamoeba histolytica elongation factor-2 kinase, putative 0.0049 0.0126 0.3291
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0018 0.0007 0.0008
Brugia malayi Metabotropic glutamate receptor precursor. 0.0095 0.0306 0.0932
Echinococcus granulosus slit 2 protein 0.0054 0.0147 0.0141
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0007 0.0001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0126 0.0376
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0086 0.0249
Echinococcus granulosus dual specificity 0.0085 0.0267 0.0261
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0038 0.0085 0.0252
Brugia malayi hypothetical protein 0.002 0.0014 0.0032
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0153 0.0456
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0007 0.0001
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0086 0.02
Echinococcus granulosus metabotropic glutamate receptor 5 0.0117 0.039 0.0385
Brugia malayi Cytochrome P450 family protein 0.0073 0.0221 0.0671
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0122
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0085 0.008
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0014 0.0008
Brugia malayi Cation transporter family protein 0.0038 0.0085 0.0252
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0081 0.0186
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2617 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0082 0.0076
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2037
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0089 0.0206
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0854 0.0849
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0014 0.0033
Brugia malayi ecdysteroid receptor 0.0037 0.0081 0.0237
Brugia malayi Pre-SET motif family protein 0.086 0.3244 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0153 0.3519
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0018 0.0007 0.0001
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0014 0.0008
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0085 0.008
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0063 0.0752
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0066 0.0187
Brugia malayi hypothetical protein 0.0288 0.1046 0.3217
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0049 0.0126 0.2838
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0082 0.0076
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.0159 0.4231
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0018 0.0007 0.0001
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.0085 0.0245
Onchocerca volvulus Serine\/threonine kinase homolog 0.009 0.0287 0.076
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0039 0.1077
Schistosoma mansoni nAChR subunit 0.0038 0.0085 0.0197
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0205 0.5552
Onchocerca volvulus 0.0049 0.0126 0.0325
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.0008
Schistosoma mansoni lipoxygenase 0.0055 0.015 0.0346
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.0085 0.0245
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0082 0.1968
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0086 0.0081
Schistosoma mansoni neurotransmitter gated ion channel 0.0018 0.0007 0.0015
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0014 0.0032
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0089 0.0257
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0053 0.0435
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0108 0.2702
Treponema pallidum 76K protein 0.0049 0.0126 0.0215
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0126 0.3291
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0038 0.0085 0.008
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0033
Onchocerca volvulus 0.002 0.0014 0.0023
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0086 0.02
Brugia malayi hypothetical protein 0.002 0.0014 0.0032
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0081 0.0075
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0085 0.0252
Schistosoma mansoni cpg binding protein 0.003 0.0055 0.0127
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0082 0.019
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0081 0.0237
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0205 0.5162
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0081 0.0186
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0038 0.0085 0.008
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0153 0.5
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0086 0.0081
Loa Loa (eye worm) acetylcholine receptor protein 0.0018 0.0007 0.0002
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0049 0.0126 0.012
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0085 0.0252
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0081 0.0231
Brugia malayi Kringle domain containing protein 0.0024 0.003 0.0082
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.0085 0.0252
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0081 0.0202
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0086 0.0081
Loa Loa (eye worm) hypothetical protein 0.0124 0.0415 0.1264
Onchocerca volvulus 0.0038 0.0085 0.0215
Brugia malayi hypothetical protein 0.0018 0.0007 0.0008
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.036 0.0831
Loa Loa (eye worm) glutamate receptor 0.0095 0.0306 0.0926
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.036 0.3791
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.009 0.0287 0.2953
Schistosoma mansoni tsg101-related 0.0057 0.0159 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0081 0.0231
Schistosoma mansoni nAChR subunit 0.0038 0.0085 0.0197
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0086 0.02
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0255 0.092 0.0915
Brugia malayi PXA domain containing protein 0.0038 0.0086 0.0255
Brugia malayi Zona pellucida-like domain containing protein 0.0049 0.0126 0.0377
Brugia malayi hypothetical protein 0.0238 0.0854 0.2624
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0081 0.0186
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0014 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0086 0.0213
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0053 0.1025
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0053 0.0074
Entamoeba histolytica hypothetical protein 0.0038 0.0086 0.2154
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0086 0.0081
Echinococcus granulosus collagen alpha 1VII chain 0.0049 0.0126 0.012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0049 0.0132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0153 0.4031
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0093 0.0087
Chlamydia trachomatis endonuclease IV 0.008 0.0248 1
Schistosoma mansoni serine-rich repeat protein 0.0615 0.2302 0.532
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0153 0.0462
Brugia malayi EGF-like domain containing protein 0.0054 0.0147 0.0441
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0126 0.3291
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0081 0.0237
Onchocerca volvulus 0.0124 0.0415 0.1108
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0085 0.008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0063 0.1427
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0231 0.0826 0.2534
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0249
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1371 0.521 1
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0287 0.0663
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0081 0.0186
Schistosoma mansoni zinc finger protein 0.0017 0.0006 0.0014
Brugia malayi hypothetical protein 0.0106 0.0347 0.1059
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0049 0.0126 0.0377
Schistosoma mansoni hypothetical protein 0.0037 0.0082 0.019
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0018 0.0043
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.011 0.0327
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0085 0.0245
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0018 0.0007 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0323 0.0745
Loa Loa (eye worm) hypothetical protein 0.0527 0.1965 0.605
Onchocerca volvulus 0.0049 0.0126 0.0325
Schistosoma mansoni nAChR subunit 0.0038 0.0085 0.0197
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0085 0.0245
Schistosoma mansoni hypothetical protein 0.0615 0.2302 0.532
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0086 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0238 0.0854 0.2619
Brugia malayi laminin alpha chain 0.0054 0.0147 0.0441
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Echinococcus granulosus histone lysine methyltransferase setb 0.0124 0.0415 0.041
Brugia malayi tailless protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0288 0.1046 0.3213
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0081 0.0075
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.0262 0.0256
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2037
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0086 0.0816
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0006 0.0006
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0085 0.008
Giardia lamblia Sgs1 DNA helicase, putative 0.0038 0.0086 0.2824
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0018 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0053 0.1617
Brugia malayi Protein kinase domain containing protein 0.0024 0.003 0.0082
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0576 0.2152 0.4971
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0085 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0025
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0038 0.0086 0.0081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0189 0.0436
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0231
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0026
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0082 0.0596
Schistosoma mansoni ap endonuclease 0.0056 0.0153 0.0355
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0085 0.0267 0.7113
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0006 0.0014
Schistosoma mansoni nAChR subunit 0.0018 0.0007 0.0015
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0086 0.0081
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0205 0.2007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0122 0.0364
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.0188 0.057
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0258 0.0779
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0038 0.0085 0.008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0085 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0086 0.0213
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.036 0.1092
Schistosoma mansoni polycystin 1-related 0.002 0.0014 0.0033
Brugia malayi nuclear receptor RXR 0.0019 0.0014 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0014 0.0031
Echinococcus granulosus leukotriene A 4 hydrolase 0.0231 0.0826 0.0821
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Echinococcus granulosus pikachurin 0.0054 0.0147 0.0141
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0081 0.0186
Schistosoma mansoni hypothetical protein 0.0255 0.092 0.2126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.003 0.0472
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0082 0.0076
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0085 0.008
Echinococcus multilocularis expressed protein 0.0033 0.0066 0.0061
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0122
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0086 0.0255
Echinococcus granulosus cpg binding protein 0.003 0.0055 0.0049
Brugia malayi Cation transporter family protein 0.0038 0.0085 0.0252
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.0899 0.2077
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0018 0.0041
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.0085 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0082 0.0202
Brugia malayi Doublecortin family protein 0.002 0.0014 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0081 0.0237
Schistosoma mansoni hypothetical protein 0.0168 0.0585 0.1352
Loa Loa (eye worm) hypothetical protein 0.0048 0.0122 0.0358
Giardia lamblia Kinase, PLK 0.009 0.0287 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0251
Trypanosoma cruzi polo-like protein kinase, putative 0.009 0.0287 0.7893
Mycobacterium ulcerans epimerase 0.0021 0.002 0.0142
Echinococcus multilocularis voltage dependent calcium channel subunit 0.119 0.4515 0.4512
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0153 0.4031
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.0085 0.008
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0085 0.008
Trichomonas vaginalis set domain proteins, putative 0.0978 0.37 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0081 0.0186
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0006 0.0014
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0108 0.0271
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0089 0.0257
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0081 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0081 0.0237
Brugia malayi hypothetical protein 0.0018 0.0007 0.0008
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0086 0.02
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0085 0.008
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0126 0.0377
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0049 0.0126 0.0371
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.036 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0249
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0089 0.0263
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0038 0.0085 0.008
Echinococcus granulosus geminin 0.0168 0.0585 0.058
Schistosoma mansoni cpg binding protein 0.0028 0.0049 0.0112
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0082 0.0242
Loa Loa (eye worm) hypothetical protein 0.008 0.0248 0.0746
Echinococcus multilocularis thyroid hormone receptor alpha 0.0292 0.1062 0.1056
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.0085 0.0252
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0124 0.0415 0.0959
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0323 0.0745
Echinococcus multilocularis tumor protein p63 0.035 0.1284 0.1278
Brugia malayi hypothetical protein 0.0026 0.0039 0.011
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0014 0.0008
Brugia malayi hypothetical protein 0.0018 0.0007 0.0008
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0086 0.02
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0082 0.0076
Onchocerca volvulus 0.002 0.0014 0.0023
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0038 0.0086 0.0081
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0018 0.0007 0.0008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0063 0.1427
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0085 0.0267 0.2726
Loa Loa (eye worm) hypothetical protein 0.0658 0.2469 0.7608
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0086 0.0213
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0014 0.0073
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0153 0.0395
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0006 0.0006
Loa Loa (eye worm) LGC-31 protein 0.0038 0.0085 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0231
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0085 0.0252
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.036 0.0354
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1142 0.4328 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0147 0.0435
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0249
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0085 0.008
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.003 0.0025
Brugia malayi ecdysone receptor 0.0017 0.0006 0.0006
Schistosoma mansoni lamin 0.0083 0.0258 0.0596
Brugia malayi hypothetical protein 0.0049 0.0126 0.0377
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0086 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0089 0.0206
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0085 0.008
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0053 0.0435
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0086 0.02
Schistosoma mansoni nAChR subunit 0.0038 0.0085 0.0197
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0086 0.0249
Echinococcus multilocularis lamin 0.0083 0.0258 0.0252
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0085 0.0245
Schistosoma mansoni lamin 0.0083 0.0258 0.0596
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0086 0.02
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0081 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0415 0.0959
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0006 0.0014
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0085 0.0267 0.0807
Loa Loa (eye worm) fli-1 protein 0.021 0.0745 0.2281
Echinococcus multilocularis RUN 0.002 0.0014 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.025 0.0899 1
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.036 0.0953
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0018 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0287 0.0756
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0085 0.0252
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0069 0.0204 0.0613
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0126 0.0377
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0287 0.0756
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0147 0.0435
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0049 0.0126 0.1263
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0042 0.0815
Loa Loa (eye worm) phosphofructokinase 0.0109 0.036 0.1092
Loa Loa (eye worm) hypothetical protein 0.0084 0.0262 0.0791
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0248 0.0752
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.0085 0.0252
Echinococcus multilocularis expressed protein 0.0746 0.2807 0.2802
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0108 0.2127
Onchocerca volvulus 0.0049 0.0126 0.0325
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0006 0.0014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0092 0.0883
Loa Loa (eye worm) hypothetical protein 0.0117 0.039 0.1187
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0014 0.0025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.0395 0.039
Schistosoma mansoni hypothetical protein 0.0049 0.0126 0.0291
Brugia malayi nuclear receptor NHR-88 0.0017 0.0006 0.0006
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.036 0.0665
Echinococcus granulosus tumor protein p63 0.035 0.1284 0.1278
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0081 0.0186
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0287 0.0756
Plasmodium falciparum thrombospondin-related anonymous protein 0.0049 0.0126 0.4788
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.0033 0.009
Onchocerca volvulus 0.0018 0.0007 0.0002
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.009 0.0287 0.0281
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0081 0.0237
Brugia malayi Immunoglobulin I-set domain containing protein 0.0049 0.0126 0.0377
Echinococcus granulosus RUN 0.002 0.0014 0.0008
Echinococcus granulosus lamin 0.0083 0.0258 0.0252
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.036 0.395
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0037
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.01 0.0323 0.0978
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2037
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0082 0.2671
Loa Loa (eye worm) hypothetical protein 0.0051 0.0136 0.0402
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0248 0.5848
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0037
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0082 0.0076
Onchocerca volvulus 0.0083 0.0258 0.0683
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0049 0.0126 0.4788
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0248 0.6696
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0153 0.0395
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0153 0.3561
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0063 0.0557
Echinococcus multilocularis pikachurin 0.0054 0.0147 0.0141
Entamoeba histolytica protein kinase domain containing protein 0.0085 0.0267 0.7346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0415 0.0959
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0086 0.0081
Echinococcus granulosus dnaJ subfamily B 0.0406 0.1499 0.1494
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Brugia malayi intermediate filament protein 0.0083 0.0258 0.0785
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0089 0.0083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0086 0.0081
Schistosoma mansoni tsg101-related 0.007 0.0208 0.048
Schistosoma mansoni laminin gamma-3 chain 0.0054 0.0147 0.0339
Toxoplasma gondii exonuclease III APE 0.0056 0.0153 0.1574
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0231
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.0188 0.049
Schistosoma mansoni kinase 0.0046 0.0117 0.027
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0042 0.0092
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.036 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0081 0.0231
Brugia malayi hypothetical protein 0.0018 0.0007 0.0008
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0248 1
Schistosoma mansoni DNA helicase recq5 0.0038 0.0086 0.02
Brugia malayi hypothetical protein 0.0019 0.0014 0.0031
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0033
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0086 0.0081
Brugia malayi steroid hormone receptor 0.0037 0.0081 0.0237
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0038 0.0085 0.0197
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0153 0.408
Schistosoma mansoni nAChR subunit 0.0038 0.0085 0.0197
Loa Loa (eye worm) glutamate receptor 0.0038 0.0083 0.0239
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0018 0.0043
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0081 0.0186
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0126 0.0377
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0122
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0248 0.2692
Loa Loa (eye worm) cytochrome P450 family protein 0.0073 0.0221 0.0665
Onchocerca volvulus 0.0038 0.0085 0.0215
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0086 0.02
Schistosoma mansoni hypothetical protein 0.0406 0.1499 0.3463
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0006 0.0006
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.0085 0.0245
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0086 0.0213
Echinococcus multilocularis nAChR subunit 0.0038 0.0085 0.008
Onchocerca volvulus 0.0018 0.0007 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0025
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0038 0.0086 0.0081
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.0085 0.008
Brugia malayi Ets-domain containing protein 0.0069 0.0204 0.0619
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.036 0.395
Schistosoma mansoni metabotropic glutamate receptor 0.008 0.0246 0.0569
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0081 0.0237
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0038 0.0086 0.3093
Echinococcus multilocularis cpg binding protein 0.003 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0103
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0249
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.01 0.0323 0.0317
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0086 0.02
Loa Loa (eye worm) abnormal epIthelia family member 0.0054 0.0147 0.0435
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0086 0.0271 0.0825
Schistosoma mansoni lipoxygenase 0.002 0.0014 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0081 0.0186
Echinococcus granulosus GA binding protein alpha chain 0.0069 0.0204 0.0199
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0153 0.1417
Entamoeba histolytica protein kinase, putative 0.0085 0.0267 0.7346
Schistosoma mansoni DNA helicase recq1 0.0038 0.0086 0.02
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0053 0.1647
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0026
Loa Loa (eye worm) hypothetical protein 0.0054 0.0147 0.0435
Echinococcus granulosus serine:threonine protein kinase PLK1 0.009 0.0287 0.0281
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0205 0.0473
Onchocerca volvulus 0.0038 0.0085 0.0215
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.009 0.0287 0.0868
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0231
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0854 0.0849
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0258 0.0785
Schistosoma mansoni ap endonuclease 0.0056 0.0153 0.0355
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0082 0.1968
Loa Loa (eye worm) hypothetical protein 0.0059 0.0166 0.0494
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0081 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0081 0.0237
Onchocerca volvulus 0.002 0.0018 0.0032
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0081 0.0202
Entamoeba histolytica hypothetical protein 0.0038 0.0086 0.2154
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0053 0.0435
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0006 0.0006
Loa Loa (eye worm) CUTiclin-Like family member 0.0049 0.0126 0.0371
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.025 0.0899 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0018 0.0007 0.0015
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0018 0.0043
Schistosoma mansoni blooms syndrome DNA helicase 0.0045 0.0113 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0081 0.0237
Brugia malayi 6-phosphofructokinase 0.0109 0.036 0.1098
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0053 0.0122
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0038 0.0085 0.0197
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0267 0.0617
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.0095 0.2075
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0086 0.0081
Onchocerca volvulus 0.0037 0.0081 0.0202
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0085 0.008
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0006 0.0006
Brugia malayi hypothetical protein 0.0018 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0323 0.0745
Schistosoma mansoni rotamase 0.0033 0.0066 0.0154
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0205 0.5515
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0126 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0066 0.016
Schistosoma mansoni survival motor neuron protein 0.0049 0.0126 0.029
Brugia malayi follicle stimulating hormone receptor 0.0238 0.0854 0.2624
Treponema pallidum hypothetical protein 0.0049 0.0126 0.0215
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.025 0.0899 0.0893
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0153 0.0268
Brugia malayi von Willebrand Factor 0.0049 0.0126 0.0377
Entamoeba histolytica recQ family DNA helicase 0.002 0.0014 0.0082
Entamoeba histolytica hypothetical protein 0.0049 0.0126 0.3291
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0082 0.2034
Brugia malayi hypothetical protein 0.0253 0.091 0.2796
Echinococcus granulosus voltage dependent calcium channel subunit 0.119 0.4515 0.4512
Brugia malayi Ets-domain containing protein 0.0069 0.0204 0.0619
Echinococcus multilocularis geminin 0.0168 0.0585 0.058
Brugia malayi conserved hypotetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.036 0.0354
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0081 0.0237
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0085 0.0252
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0085 0.0197
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0085 0.008
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0269
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0153 0.1637
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0126 0.0377
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0007 0.0008
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0086 0.0255
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0081 0.0075
Brugia malayi 6-phosphofructokinase 0.0109 0.036 0.1098
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0086 0.0081
Brugia malayi Cation transporter family protein 0.0038 0.0085 0.0252
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0205 0.0614
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.036 0.0953
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0084
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.0085 0.0252
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0007 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0122 0.0364
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0038 0.0086 0.0081
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.0085 0.0245
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.0262 0.0256
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.0085 0.0197
Echinococcus granulosus nAChR subunit 0.002 0.0018 0.0012
Echinococcus granulosus nAChR subunit 0.0038 0.0085 0.008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0082 0.0202
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0415 0.0959
Schistosoma mansoni acetylcholine receptor-related 0.0018 0.0007 0.0015
Echinococcus granulosus expressed protein 0.0746 0.2807 0.2802
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0038 0.0085 0.0245
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0122 0.0358
Onchocerca volvulus 0.0028 0.0049 0.0116
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0093 0.0087
Onchocerca volvulus 0.0978 0.37 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0126 0.0377
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0081 0.0237
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0082 0.0076
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0153 0.5223
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.036 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0081 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0014 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0086 0.0213
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Loa Loa (eye worm) hypothetical protein 0.0081 0.0252 0.0761
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0024 0.0033 0.0084
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0082 0.019
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0082 0.1335
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0018 0.0007 0.0001
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0049 0.0126 0.0371
Schistosoma mansoni nAChR subunit 0.0038 0.0085 0.0197
Brugia malayi Pre-SET motif family protein 0.0124 0.0415 0.1269
Echinococcus multilocularis GA binding protein alpha chain 0.0069 0.0204 0.0199
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0205 0.0199
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0081 0.0075
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0039 0.073
Leishmania major hypothetical protein, conserved 0.0027 0.0042 0.0138
Loa Loa (eye worm) hypothetical protein 0.0085 0.0264 0.0798
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0076
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0085 0.0252
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0085 0.0197
Echinococcus multilocularis lamin dm0 0.0083 0.0258 0.0252
Mycobacterium ulcerans hypothetical protein 0.0021 0.002 0.0142
Loa Loa (eye worm) hypothetical protein 0.0143 0.0489 0.1491
Schistosoma mansoni nuclear receptor 0.0017 0.0006 0.0014
Schistosoma mansoni coup transcription factor 0.0037 0.0081 0.0186
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0086 0.0816
Leishmania major hypothetical protein, conserved 0.0026 0.0039 0.0104
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0039 0.0695
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0287 0.0756
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0024 0.0033 0.0084
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0081 0.0202
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0086 0.0255
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0025
Schistosoma mansoni gabp alpha 0.0069 0.0204 0.0472
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0039 0.073
Brugia malayi Fli-1 protein 0.021 0.0745 0.2286
Schistosoma mansoni hypothetical protein 0.0168 0.0585 0.1352
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0086 0.02
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0126 0.2838
Brugia malayi Sulfatase family protein 0.0018 0.0008 0.0011
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0085 0.0267 0.7324
Loa Loa (eye worm) hypothetical protein 0.0037 0.0082 0.0236
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0108 0.0356 0.0822
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0292 0.1062 0.2453
Entamoeba histolytica hypothetical protein 0.002 0.0018 0.0189
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0014 0.0032
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.002 0.0039
Onchocerca volvulus 0.0049 0.0126 0.0325
Echinococcus granulosus neurogenic locus notch protein 0.0054 0.0147 0.0141
Schistosoma mansoni nuclear receptor 0.0017 0.0006 0.0014
Entamoeba histolytica hypothetical protein 0.0085 0.0267 0.7346
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0085 0.0252
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0415 0.4532
Brugia malayi phosphofructokinase 0.0109 0.036 0.1098
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0179
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.002 0.0142
Onchocerca volvulus 0.0083 0.0258 0.0683
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0086 0.0081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0025
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0054 0.0147 0.0441
Onchocerca volvulus 0.0051 0.0136 0.0352
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.002 0.0142
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0164 0.1694
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0251
Schistosoma mansoni cpg binding protein 0.003 0.0055 0.0127
Plasmodium vivax SET domain protein, putative 0.0124 0.0415 1
Trichomonas vaginalis rotamase, putative 0.0033 0.0066 0.016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0006 0.0014
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0086 0.0255
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0231
Loa Loa (eye worm) hypothetical protein 0.0085 0.0264 0.0798
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0005
Brugia malayi hypothetical protein 0.0084 0.0262 0.0797
Schistosoma mansoni acetylcholine receptor subunit beta 0.0018 0.0007 0.0015
Onchocerca volvulus 0.0049 0.0126 0.0324
Schistosoma mansoni ets-related 0.021 0.0745 0.172
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0049 0.0126 0.2838
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.0854 0.2619
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0081 0.0075
Entamoeba histolytica protein kinase, putative 0.0085 0.0267 0.7346
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0085 0.008
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0053 0.1647
Onchocerca volvulus 0.0038 0.0085 0.0215
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0231
Trichomonas vaginalis rotamase, putative 0.0032 0.0063 0.0151
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0018 0.0008 0.0005
Onchocerca volvulus 0.0049 0.0126 0.0325
Loa Loa (eye worm) hypothetical protein 0.0084 0.0262 0.0791
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.0085 0.0252
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Loa Loa (eye worm) doublecortin family protein 0.002 0.0014 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0081 0.0231
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.3031 0.3027
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0093 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0112 0.0283
Echinococcus multilocularis dual specificity 0.0085 0.0267 0.0261
Onchocerca volvulus Putative nachr subunit 0.0038 0.0085 0.0215
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0081 0.0186
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0085 0.008
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0038 0.0086 0.0249
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0231
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0153 0.0148
Toxoplasma gondii kringle domain-containing protein 0.0024 0.003 0.0183
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Echinococcus granulosus transcription factor Dp 1 0.004 0.0093 0.0087
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0085 0.008
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0063 0.1497
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0086 0.0081
Brugia malayi Zona pellucida-like domain containing protein 0.0049 0.0126 0.0377
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0037
Schistosoma mansoni eyes absent homolog 0.0084 0.0262 0.0605
Echinococcus multilocularis metabotropic glutamate receptor 2 0.008 0.0246 0.024
Brugia malayi laminin-like protein K08C7.3 precursor 0.0054 0.0147 0.0441
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0108 0.2762
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.003 0.069
Brugia malayi nuclear hormone receptor 0.0037 0.0081 0.0237
Toxoplasma gondii microneme protein MIC2 0.0049 0.0126 0.1263
Brugia malayi nuclear receptor NHR-88 0.0037 0.0081 0.0237
Trichomonas vaginalis hypothetical protein 0.0041 0.0096 0.024
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0018 0.0007 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0899 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.1499 0.1494
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0081 0.0237
Schistosoma mansoni cell polarity protein 0.0054 0.0147 0.0339
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Echinococcus multilocularis bloom syndrome protein 0.0065 0.0188 0.0183
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0085 0.0267 0.7324
Brugia malayi nuclear receptor NHR-67 0.0017 0.0006 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0082 0.019
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0085 0.0252
Brugia malayi hypothetical protein 0.0037 0.0082 0.0242
Loa Loa (eye worm) hypothetical protein 0.01 0.0323 0.0978
Loa Loa (eye worm) RecQ helicase 0.0065 0.0188 0.0564
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0082 0.0202
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.015 0.0144
Plasmodium vivax thrombospondin-related anonymous protein 0.0049 0.0126 0.2838
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.0188 0.049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0064 0.0185
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0049 0.0126 0.2838
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0081 0.0237
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.003 0.0076
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0258 0.0779
Schistosoma mansoni loxhd1 0.002 0.0014 0.0033
Echinococcus granulosus lamin dm0 0.0083 0.0258 0.0252
Echinococcus multilocularis nAChR subunit 0.002 0.0018 0.0012
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0255 0.092 0.0915
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.0085 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0112 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0081 0.0237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0081 0.0237
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0287 0.0756
Onchocerca volvulus 0.0038 0.0085 0.0215
Echinococcus granulosus metabotropic glutamate receptor 2 0.008 0.0246 0.024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.011 0.0321
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0081 0.0237
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0205 0.062
Trypanosoma cruzi polo-like protein kinase, putative 0.009 0.0287 0.7893
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0053 0.1025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0005
Onchocerca volvulus 0.0024 0.003 0.0066
Brugia malayi PXA domain containing protein 0.0038 0.0086 0.0255
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.0008
Brugia malayi metabotropic glutamate receptor type 2 0.0046 0.0118 0.0352
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0086 0.0081
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0205 0.0199
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.036 1
Brugia malayi nuclear hormone receptor 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Schistosoma mansoni hypothetical protein 0.0024 0.003 0.007
Onchocerca volvulus 0.0288 0.1046 0.2816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0081 0.0231
Brugia malayi hypothetical protein 0.0084 0.0262 0.0796
Loa Loa (eye worm) CUTiclin family member 0.0049 0.0126 0.0371
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0085 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0081 0.0231
Schistosoma mansoni intermediate filament proteins 0.0083 0.0258 0.0596
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0082 0.0076
Onchocerca volvulus 0.002 0.0018 0.0032
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0086 0.0081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0249
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0126 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0089 0.0206
Echinococcus granulosus expressed protein 0.0033 0.0066 0.0061
Brugia malayi CXXC zinc finger family protein 0.0028 0.0049 0.0138
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0007 0.0008
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0066 0.0193
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.036 0.0953
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0018 0.0041
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0086 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0081 0.0231
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.036 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0085 0.0197
Schistosoma mansoni hypothetical protein 0.0049 0.0126 0.029
Onchocerca volvulus 0.0049 0.0126 0.0325
Brugia malayi nuclear receptor RXR 0.0017 0.0006 0.0006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0153 0.5966
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.002 0.005
Onchocerca volvulus 0.0038 0.0085 0.0215
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0086 0.0255
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0086 0.0249
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0049 0.0126 0.4788
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0231 0.0826 0.1909
Schistosoma mansoni slit 0.0054 0.0147 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0081 0.0237
Schistosoma mansoni hypothetical protein 0.0032 0.0064 0.0148
Brugia malayi hypothetical protein 0.0019 0.0014 0.0031
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0049 0.0126 0.0321
Brugia malayi hypothetical protein 0.0038 0.0086 0.0255
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.025 0.0899 0.0893
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0231 0.0826 0.0821
Trypanosoma brucei polo-like protein kinase 0.009 0.0287 0.7727
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0086 0.0255
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0117 0.039 0.0385
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0053 0.1188
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.003 0.0469
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0081 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0899 1
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.036 0.0953
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0153 0.0148
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0287 0.0756
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0002
Brugia malayi serine/threonine-protein kinase plk-2 0.009 0.0287 0.0873
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0136 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0086 0.0213
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0108 0.0888
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0085 0.008
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0054 0.0147 0.0339
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0231
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0086 0.0213
Loa Loa (eye worm) hypothetical protein 0.0083 0.0258 0.0779
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0205 0.5515
Echinococcus multilocularis slit 2 protein 0.0054 0.0147 0.0141
Schistosoma mansoni hypothetical protein 0.0049 0.0126 0.0291
Brugia malayi hypothetical protein 0.0038 0.0086 0.0255
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0037
Schistosoma mansoni tsg101-related 0.007 0.0208 0.048
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0086 0.0255
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0086 0.02
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0037
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0371
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0249
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0081 0.0075
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0006 0.0006
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0039 0.0285

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 16 uM Binding affinity to Tsg101 (unknown origin) ChEMBL. 18083557
IC50 (binding) = 16 uM Binding affinity to Tsg101 (unknown origin) ChEMBL. 18083557

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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