Detailed information for compound 505610

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1632.7 | Formula: C77H93N13O25S
  • H donors: 15 H acceptors: 21 LogP: 0.8 Rotable bonds: 45
    Rule of 5 violations (Lipinski): 4
  • SMILES: COc1ccc(cc1O)/C=N\O[C@@H]1C[C@H](N(C1)C(=O)C1CCCCN1C(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CCCCNC(=S)Nc1ccc2c(c1)C1(OC2=O)c2ccc(cc2Oc2c1ccc(c2)O)O)CCC(=O)O)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCC(=O)O)CCC(=O)O
  • InChi: 1S/C77H93N13O25S/c1-39(72(108)89-29-7-5-10-55(89)74(110)90-38-45(115-80-37-41-14-24-58(112-3)57(94)32-41)36-56(90)70(106)84-51(22-26-63(98)99)67(103)83-50(66(78)102)21-25-62(96)97)81-71(107)65(40(2)91)86-69(105)54-12-9-31-88(54)73(109)52(23-27-64(100)101)85-68(104)53-11-8-30-87(53)61(95)13-4-6-28-79-76(116)82-42-15-18-46-49(33-42)77(114-75(46)111)47-19-16-43(92)34-59(47)113-60-35-44(93)17-20-48(60)77/h14-20,24,32-35,37,39-40,45,50-56,65,91-94H,4-13,21-23,25-31,36,38H2,1-3H3,(H2,78,102)(H,81,107)(H,83,103)(H,84,106)(H,85,104)(H,86,105)(H,96,97)(H,98,99)(H,100,101)(H2,79,82,116)/b80-37-/t39-,40+,45+,50-,51-,52-,53-,54-,55?,56-,65-/m0/s1
  • InChiKey: HTXIMEIDWFNFAN-GITYUUEWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0483 0.2503 0.6615
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0036 0.0082 0.0128
Brugia malayi Dopamine receptor protein 1 0.0052 0.0166 0.044
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0039 0.0101 0.0066
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.014 0.0648 0.3967
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0166 0.044
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0038 0.0092 0.0195
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0166 0.044
Leishmania major hypothetical protein, unknown function 0.0038 0.0092 0.008
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0077 0.0306 0.1715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0166 0.044
Onchocerca volvulus 0.0223 0.1098 0.8237
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0109 0.048 0.048
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0166 0.0166
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0476 0.3574
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0369 0.1888 0.4992
Schistosoma mansoni hypothetical protein 0.0036 0.0084 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0289 0.1453 0.3842
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0166 0.044
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0166 0.0166
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0224 0.0592
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0054 0.0178 0.098
Echinococcus granulosus hypothetical protein 0.0052 0.0166 0.044
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0113 0.0377
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0166 0.0166
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0077 0.0306 0.0808
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0113 0.0325
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0322 0.1633 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0101 0.0266
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0038 0.0092 0.0244
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0008 0.002
Echinococcus granulosus muscleblind protein 0.0344 0.175 0.4626
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0166 0.0166
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Plasmodium vivax phosphodiesterase gamma, putative 0.014 0.0648 0.3967
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0306 0.1677
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.1076 0.2844
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Onchocerca volvulus 0.0071 0.027 0.203
Plasmodium falciparum sentrin-specific protease 1 0.0054 0.0178 0.1304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.014 0.0648 0.3683
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.1238 0.3272
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0166 0.044
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0166 0.044
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0038 0.0092 0.0244
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0166 0.044
Schistosoma mansoni alpha-glucosidase 0.0161 0.0762 0.2014
Echinococcus multilocularis AMP deaminase 2 0.0087 0.0358 0.0358
Brugia malayi Dopamine receptor 0.0052 0.0166 0.044
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0719 0.3783 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.014 0.0648 0.3729
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0062 0.0224 0.1033
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0166 0.0166
Schistosoma mansoni dopamine-beta-monooxygenase 0.0699 0.3676 0.9717
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0038 0.0092 0.0244
Loa Loa (eye worm) hypothetical protein 0.0267 0.1333 0.3523
Schistosoma mansoni biogenic amine receptor 0.0052 0.0166 0.044
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0166 0.0166
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Leishmania major hypothetical protein, conserved 0.004 0.0105 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0266 0.1519
Trypanosoma cruzi AMP deaminase, putative 0.0087 0.0358 0.1887
Brugia malayi Adenosine/AMP deaminase family protein 0.0267 0.1333 0.3523
Toxoplasma gondii hypothetical protein 0.0077 0.0304 0.1146
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0322 0.1633 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0166 0.044
Brugia malayi DOMON domain containing protein 0.0071 0.027 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trichomonas vaginalis guanylate cyclase, putative 0.0036 0.008 0.0416
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0166 0.044
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0166 0.044
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0166 0.044
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0266 0.0994
Brugia malayi Muscleblind-like protein 0.0344 0.175 0.4626
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.0903 0.2388
Loa Loa (eye worm) hypothetical protein 0.0369 0.1888 0.4992
Schistosoma mansoni biogenic amine receptor 0.0052 0.0166 0.044
Onchocerca volvulus 0.0052 0.0166 0.1248
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0369 0.1888 0.1888
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0273 0.1365 0.8291
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0476 0.0476
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0062 0.0224 0.1372
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1453 0.8317
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0109 0.048 0.2662
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0273 0.1365 0.5418
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0077 0.0306 0.0885
Loa Loa (eye worm) hypothetical protein 0.0308 0.1557 0.4115
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0077 0.0306 0.1715
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0038 0.0092 0.0295
Onchocerca volvulus 0.0031 0.0058 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Onchocerca volvulus 0.0052 0.0166 0.1248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0458 0.121
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0223 0.059
Toxoplasma gondii endonuclease IV APN 0.008 0.0319 0.1208
Mycobacterium ulcerans putative regulatory protein 0.0077 0.0304 0.1735
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0084 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0648 0.3729
Leishmania major protein kinase, putative 0.0036 0.0082 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0223 0.059
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0719 0.3783 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0166 0.044
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0054 0.0178 0.047
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0166 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0166 0.044
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0077 0.0306 0.1715
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.014 0.0648 0.1712
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0113 0.0605
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0062 0.0224 0.0592
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0306 0.1677
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0166 0.0166
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0093 0.0528
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0166 0.044
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0483 0.2503 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0084 0.0222
Onchocerca volvulus 0.025 0.124 0.9306
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0166 0.044
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0038 0.0092 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Schistosoma mansoni amine GPCR 0.0052 0.0166 0.044
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0113 0.0298
Echinococcus granulosus g protein coupled receptor 0.0052 0.0166 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.008 0.0416
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Schistosoma mansoni hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0301 0.1517 0.4009
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0322 0.1633 0.4317
Loa Loa (eye worm) hypothetical protein 0.0249 0.1238 0.3272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0036 0.008 0.0416
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0166 0.0166
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0223 0.059
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0212 0.1037 0.6207
Echinococcus multilocularis dnaJ subfamily C 6 0.0071 0.0269 0.0269
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0166 0.044
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.0306 0.0808
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0093 0.0246
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0077 0.0306 0.1715
Loa Loa (eye worm) hypothetical protein 0.0196 0.0949 0.2508
Brugia malayi Serotonin receptor 0.0052 0.0166 0.044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Loa Loa (eye worm) hypothetical protein 0.0223 0.1098 0.2902
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Schistosoma mansoni AMP deaminase 0.0087 0.0358 0.0947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0458 0.121
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0289 0.1453 0.8834
Schistosoma mansoni hypothetical protein 0.0036 0.0084 0.0222
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0289 0.1453 0.8317
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0369 0.1888 0.4992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0483 0.2503 0.2503
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0086 0.0351 0.1976
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0476 0.2697
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0289 0.1453 0.8856
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0092 0.0566
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0319 0.0843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0458 0.121
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0211
Mycobacterium ulcerans adenosine deaminase 0.0267 0.1333 0.7632
Leishmania major cAMP-specific phosphodiesterase, putative 0.014 0.0648 0.3656
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0092 0.0295
Echinococcus multilocularis 0.0062 0.0224 0.0224
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.0903 0.2388
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0166 0.044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0223 0.1098 0.2902
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0113 0.0161
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0113 0.0605
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0336 0.1709 0.4519
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0289 0.1453 0.8317
Schistosoma mansoni adenosylhomocysteinase 0.0169 0.0802 0.2119
Plasmodium falciparum GAF domain-related protein, putative 0.0077 0.0304 0.2226
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0087 0.0358 0.1792
Schistosoma mansoni adenosine deaminase-related 0.0267 0.1333 0.3523
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0058 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0648 0.3683
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0166 0.044
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.014 0.0648 0.3683
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0109 0.048 0.2718
Loa Loa (eye worm) hypothetical protein 0.018 0.0862 0.2278
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.018 0.0862 0.2278
Onchocerca volvulus 0.0051 0.0163 0.1222
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0223 0.1098 0.2902
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0058 0.0153
Schistosoma mansoni myosin xvIII 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0196 0.0949 0.2508
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0113 0.0605
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Loa Loa (eye worm) adenosylhomocysteinase 0.0273 0.1365 0.3607
Echinococcus multilocularis neuropeptide receptor A26 0.0052 0.0166 0.0166
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0117 0.0522 0.3819
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0166 0.0166
Brugia malayi G protein-coupled receptor 0.0052 0.0166 0.044
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0038 0.0092 0.0195
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0267 0.1333 0.9767
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0166 0.0166
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0166 0.044
Trypanosoma brucei glucosidase, putative 0.0042 0.0113 0.0133
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0087 0.0358 0.1792
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0273 0.1365 0.8257
Entamoeba histolytica AMP deaminase, putative 0.0087 0.0358 0.209
Echinococcus granulosus neuropeptide s receptor 0.0052 0.0166 0.044
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0187 0.0903 0.2386
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0032 0.0062 0.0163
Echinococcus multilocularis adenosylhomocysteinase 0.0273 0.1365 0.1365
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0179 0.0986
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0084 0.0222
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0077 0.0306 0.1385
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.014 0.0648 0.3605
Loa Loa (eye worm) hypothetical protein 0.0038 0.0092 0.0244
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0212 0.1037 0.5922
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0038 0.0092 0.0195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0166 0.044
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1453 0.8317
Schistosoma mansoni hypothetical protein 0.0038 0.0092 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0458 0.121
Onchocerca volvulus 0.0223 0.1098 0.8237
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0289 0.1453 0.1453
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0038 0.0092 0.0244
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0342 0.1742 0.4605
Loa Loa (eye worm) hypothetical protein 0.0196 0.0949 0.2508
Onchocerca volvulus 0.0052 0.0166 0.1248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0289 0.1453 0.3842
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0441 0.2277 0.2277
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0483 0.2503 1
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0093 0.0093
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0166 0.044
Leishmania major phosphatidylinositol 3-kinase, putative 0.0038 0.0092 0.008
Brugia malayi jmjC domain containing protein 0.0062 0.0223 0.059
Loa Loa (eye worm) hypothetical protein 0.0087 0.0358 0.0947
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0255 0.1268 0.3351
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0304 0.186
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0273 0.1365 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0342 0.1742 0.4605
Giardia lamblia Kinase, PLK 0.0109 0.0476 0.1593
Loa Loa (eye worm) hypothetical protein 0.018 0.0862 0.2278
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0038 0.0092 0.0195
Leishmania major hypothetical protein, conserved 0.014 0.0648 0.3656
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0342 0.1742 0.1742
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0109 0.048 0.1269
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.014 0.0648 0.0648
Echinococcus granulosus neuropeptide receptor A26 0.0052 0.0166 0.044
Echinococcus multilocularis neuropeptide s receptor 0.0052 0.0166 0.0166
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0267 0.1333 0.9767
Brugia malayi ORL1-like opioid receptor 0.0052 0.0166 0.044
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0166 0.0166
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0092 0.0671
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0077 0.0306 0.0808
Trichomonas vaginalis conserved hypothetical protein 0.0329 0.1671 0.9571
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0036 0.0082 0.0128
Loa Loa (eye worm) hypothetical protein 0.018 0.0862 0.2278
Schistosoma mansoni hypothetical protein 0.0052 0.0166 0.044
Brugia malayi DOMON domain containing protein 0.0071 0.027 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Echinococcus multilocularis serotonin receptor 0.0052 0.0166 0.0166
Loa Loa (eye worm) PDE1B protein 0.0719 0.3783 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0113 0.0605
Toxoplasma gondii hypothetical protein 0.0077 0.0304 0.1146
Trypanosoma brucei AMP deaminase, putative 0.0087 0.0358 0.1725
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0153
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0092 0.0566
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0306 0.1677
Schistosoma mansoni biogenic amine receptor 0.0052 0.0166 0.044
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.014 0.0648 0.1712
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0306 0.0808
Loa Loa (eye worm) hypothetical protein 0.0224 0.11 0.2908
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0369 0.1888 0.4992
Onchocerca volvulus 0.0052 0.0166 0.1248
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0476 0.1259
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0038 0.0092 0.0092
Plasmodium falciparum adenosylhomocysteinase 0.0273 0.1365 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0036 0.008 0.0416
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.014 0.0648 0.3605
Schistosoma mansoni adenosylhomocysteinase 0.0169 0.0802 0.2119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0058 0.0153
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Trypanosoma brucei hypothetical protein, conserved 0.014 0.0648 0.3605
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0002
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0109 0.048 0.1269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0166 0.044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0166 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0648 0.3729
Plasmodium vivax adenosine deaminase, putative 0.0267 0.1333 0.816
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0166 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0092 0.0244
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0062 0.0224 0.1033
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Plasmodium falciparum AMP deaminase, putative 0.0087 0.0358 0.2625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0166 0.0166
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0369 0.1888 0.4992
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.0509 0.1346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Loa Loa (eye worm) hypothetical protein 0.0577 0.3013 0.7964
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0693 0.3943
Onchocerca volvulus 0.0052 0.0166 0.1248
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0038 0.0092 0.008
Echinococcus granulosus serine protein kinase ATM 0.0038 0.0092 0.0244
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0109 0.048 0.1269
Toxoplasma gondii FATC domain-containing protein 0.0038 0.0092 0.0295
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.014 0.0648 0.3683
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0166 0.0166
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0166 0.044
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0166 0.044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0166 0.0166
Leishmania major protein kinase, putative 0.0036 0.0082 0.0012
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0032 0.0062 0.0163
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.0166 0.044
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0087 0.0358 0.1887
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.004 0.0105 0.0277
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0312 0.0826
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0166 0.044
Echinococcus multilocularis Zinc finger, PHD finger 0.0077 0.0306 0.0306
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0166 0.044
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0476 0.2638
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0476 0.1259
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0306 0.1677
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0036 0.008 0.0211
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0077 0.0304 0.2221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Onchocerca volvulus 0.0052 0.0166 0.1248
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0036 0.008 0.0416
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.014 0.0648 0.3683
Echinococcus multilocularis somatostatin receptor 0.0052 0.0166 0.0166
Brugia malayi neuropeptide F receptor 0.0052 0.0166 0.044
Leishmania major hypothetical protein, conserved 0.0087 0.0358 0.1792
Loa Loa (eye worm) hypothetical protein 0.0336 0.1709 0.4519
Echinococcus multilocularis GPCR, family 2 0.0036 0.0084 0.0084
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0344 0.175 0.4626
Loa Loa (eye worm) DnaJ domain-containing protein 0.0071 0.0269 0.0712
Schistosoma mansoni adenosylhomocysteinase 0.0273 0.1365 0.3607
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0289 0.1453 0.8317
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0038 0.0092 0.0295
Schistosoma mansoni adenosine deaminase 0.0267 0.1333 0.3523
Trichomonas vaginalis adenylate cyclase, putative 0.0036 0.008 0.0416
Brugia malayi putative neuropeptide receptor 0.0052 0.0166 0.044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0166 0.044
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0036 0.008 0.0416
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0038 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0032 0.0062 0.0163
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0038 0.0092 0.0195
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0077 0.0306 0.1715
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0289 0.1453 0.8317
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0036 0.0084 0.0222
Loa Loa (eye worm) hypothetical protein 0.0077 0.0306 0.0808
Echinococcus granulosus g protein coupled receptor 0.0052 0.0166 0.044
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0077 0.0306 0.1677
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) DOMON domain-containing protein 0.0071 0.027 0.0715
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0289 0.1453 0.8317
Brugia malayi G-protein coupled receptor 0.0052 0.0166 0.044
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0719 0.3783 0.3783
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0306 0.0808
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0166 0.044
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0322 0.1633 0.6499
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Mycobacterium leprae Possible regulatory protein 0.0036 0.008 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0476 0.2697
Brugia malayi Serotonin receptor 0.0052 0.0166 0.044
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0109 0.048 0.1269
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0166 0.044
Brugia malayi DOMON domain containing protein 0.0071 0.027 0.0715
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0483 0.2503 0.6615
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0182 0.0873 0.2308
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0648 0.3729
Schistosoma mansoni hypothetical protein 0.0078 0.0312 0.0826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Leishmania major phosphatidylinositol kinase, putative 0.0038 0.0092 0.008
Schistosoma mansoni adenoreceptor 0.0052 0.0166 0.044
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0166 0.044
Trichomonas vaginalis protein kinase inhibitor, putative 0.0071 0.0269 0.1506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0062 0.0224 0.0592
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0483 0.2503 0.6615
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0113 0.0298
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0329 0.1671 0.9571
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Brugia malayi Pre-SET motif family protein 0.0031 0.0058 0.0153
Echinococcus granulosus adenosylhomocysteinase 0.0273 0.1365 0.3607
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0441 0.2277 0.6019
Echinococcus multilocularis serine protein kinase ATM 0.0038 0.0092 0.0092
Brugia malayi GnHR receptor homolog 0.0052 0.0166 0.044
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0117 0.0522 0.2984
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0166 0.044
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0087 0.0358 0.1725
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0166 0.044
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0109 0.048 0.2516
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0077 0.0306 0.224
Trypanosoma cruzi AMP deaminase, putative 0.0087 0.0358 0.1887
Echinococcus granulosus adenosine deaminase 0.0267 0.1333 0.3523
Trichomonas vaginalis guanylate cyclase, putative 0.0036 0.008 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0092 0.0488
Brugia malayi Adenosylhomocysteinase 0.0273 0.1365 0.3607
Echinococcus multilocularis sex peptide receptor 0.0052 0.0166 0.0166
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0223 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0092 0.0671
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.014 0.0648 0.1712
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Loa Loa (eye worm) hypothetical protein 0.0038 0.0092 0.0244
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0166 0.044
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0166 0.0166
Brugia malayi jmjC domain containing protein 0.0062 0.0223 0.059
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0166 0.0166
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0255 0.1268 0.5028
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.008 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0062 0.0224 0.0855
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0113 0.0605
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.004 0.0105 0.0277
Loa Loa (eye worm) hypothetical protein 0.0369 0.1888 0.4992
Giardia lamblia Hypothetical protein 0.014 0.0648 0.2305
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0109 0.048 0.2576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Echinococcus granulosus serotonin receptor 0.0052 0.0166 0.044
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0077 0.0306 0.1715
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0166 0.044
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0203 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0322 0.1633 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0038 0.0092 0.0195
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.0509 0.1346
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0223 0.1098 0.2902
Brugia malayi Melatonin receptor type 1A 0.0052 0.0166 0.044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0058 0.0153
Brugia malayi hypothetical protein 0.0249 0.1238 0.3272
Trypanosoma brucei AMP deaminase, putative 0.0087 0.0358 0.1725
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0336 0.1709 0.4519
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0062 0.0224 0.1643
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0224 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Onchocerca volvulus 0.0052 0.0166 0.1248
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0223 0.1098 0.2902
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0166 0.044
Plasmodium falciparum cGMP-specific phosphodiesterase 0.014 0.0648 0.4747
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0166 0.0166
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0036 0.0082 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0476 0.2697
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0036 0.008 0.008
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.014 0.0648 0.3683
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0306 0.1154
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Schistosoma mansoni opsin-like receptor 0.0052 0.0166 0.044
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0166 0.044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0266 0.0703
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0166 0.044
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0304 0.2221
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0648 0.3729
Onchocerca volvulus 0.0108 0.0475 0.3564
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0319 0.2338
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0092 0.0195
Onchocerca volvulus 0.0052 0.0166 0.1248
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0483 0.2503 0.2503
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0166 0.044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0166 0.044
Trichomonas vaginalis adenosine deaminase, putative 0.0267 0.1333 0.7623
Trypanosoma cruzi AMP deaminase, putative 0.0087 0.0358 0.1887
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0319 0.1954
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0223 0.0223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0092 0.0244
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0092 0.0244
Brugia malayi PAS domain containing protein 0.0074 0.0286 0.0755
Schistosoma mansoni amine GPCR 0.0052 0.0166 0.044
Leishmania major hypothetical protein, conserved 0.0038 0.0092 0.008
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0109 0.048 0.2718
Echinococcus multilocularis serotonin receptor 0.0052 0.0166 0.0166
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0223 0.1098 0.2902
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0058 0.0153
Echinococcus granulosus aryl hydrocarbon receptor 0.0036 0.008 0.0211
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0223 0.059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trichomonas vaginalis set domain proteins, putative 0.025 0.124 0.7091
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0166 0.044
Schistosoma mansoni fkbp-rapamycin associated protein 0.0038 0.0092 0.0244
Echinococcus multilocularis sentrin specific protease 1 0.0054 0.0178 0.0178
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0273 0.1365 0.7815
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.014 0.0648 0.3729
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0166 0.044
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0038 0.0092 0.0244
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0166 0.0166
Onchocerca volvulus 0.0052 0.0166 0.1248
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0441 0.2277 0.6019
Schistosoma mansoni neuropeptide receptor 0.0052 0.0166 0.044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0084 0.0084
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.014 0.0648 0.3605
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0166 0.044
Brugia malayi G-protein coupled receptor 0.0052 0.0166 0.044
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0166 0.044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0105 0.0458 0.121
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0092 0.0677
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0038 0.0092 0.0195
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0342 0.1742 0.4605
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0319 0.2333
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0102 0.0437 0.1684
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.0306 0.0306
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0166 0.0166
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.014 0.0648 0.1712
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0319 0.2333
Loa Loa (eye worm) phosphatidylinositol 3 0.0223 0.1098 0.2902
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0113 0.0325
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0181 0.0866 0.4937
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0267 0.1333 0.5289
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.0509 0.1346
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0077 0.0306 0.0808
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.0903 0.2388
Trypanosoma cruzi AMP deaminase, putative 0.0087 0.0358 0.1887
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.0166 0.0166
Toxoplasma gondii AMP deaminase 0.0087 0.0358 0.1365
Onchocerca volvulus 0.0052 0.0166 0.1248
Onchocerca volvulus 0.0052 0.0166 0.1248
Schistosoma mansoni adenosylhomocysteinase 0.0169 0.0802 0.2119
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0217 0.1064 0.6078
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0166 0.044
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0217 0.1064 0.6078
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0113 0.0605
Loa Loa (eye worm) hypothetical protein 0.0054 0.0178 0.047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0166 0.044
Schistosoma mansoni hypothetical protein 0.0036 0.0084 0.0222
Loa Loa (eye worm) hypothetical protein 0.0344 0.175 0.4626
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.007 0.0267 0.0997
Schistosoma mansoni amine GPCR 0.0052 0.0166 0.044
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0001 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0105 0.0458 0.121
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.0166 0.1248
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.014 0.0648 0.1712
Loa Loa (eye worm) DOMON domain-containing protein 0.0071 0.027 0.0715
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0648 0.3729
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0001 0.0007
Loa Loa (eye worm) AMP deaminase 0.0087 0.0358 0.0947
Echinococcus granulosus bloom syndrome protein 0.0022 0.0008 0.002
Leishmania major S-adenosylhomocysteine hydrolase 0.0273 0.1365 0.8271
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0036 0.0082 0.0128
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0266 0.1198
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0166 0.0166
Echinococcus granulosus allatostatin A receptor 0.0052 0.0166 0.044
Onchocerca volvulus 0.0036 0.008 0.06
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.0166 0.0166
Schistosoma mansoni neuropeptide receptor 0.0052 0.0166 0.044
Toxoplasma gondii GAF domain-containing protein 0.0077 0.0304 0.1146
Schistosoma mansoni hypothetical protein 0.0051 0.0163 0.0431
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0077 0.0306 0.1715
Leishmania major phosphatidylinositol 3-kinase, putative 0.0077 0.0306 0.1453
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0087 0.0358 0.1887
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0166 0.0166
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0038 0.0092 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0304 0.1704
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0038 0.0092 0.0488
Echinococcus multilocularis muscleblind protein 1 0.0344 0.175 0.175
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0058 0.0156
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0166 0.044
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0038 0.0092 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0109 0.048 0.3048
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0166 0.0166
Loa Loa (eye worm) phosphatidylinositol kinase 0.0223 0.1098 0.2902
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0223 0.0223
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0212 0.1037 0.5922
Onchocerca volvulus 0.0052 0.0166 0.1248
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0113 0.0161
Entamoeba histolytica AMP deaminase, putative 0.0087 0.0358 0.209
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0266 0.1519
Echinococcus multilocularis adenosine deaminase 0.0267 0.1333 0.1333
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0092 0.0244
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0166 0.044
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.0166 0.044
Brugia malayi DnaJ domain containing protein 0.0071 0.0269 0.0712
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0038 0.0092 0.0244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0084 0.0222
Schistosoma mansoni alpha-glucosidase 0.0161 0.0762 0.2014
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0273 0.1365 0.7806
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0648 0.3683
Entamoeba histolytica adenosine deaminase, putative 0.0267 0.1333 0.975
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0343 0.1746 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0166 0.0166
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0273 0.1365 0.8355
Plasmodium vivax hypothetical protein 0.0038 0.0092 0.0566
Onchocerca volvulus Adenosine deaminase homolog 0.0267 0.1333 1
Mycobacterium ulcerans DNA-3-methyladenine glycosylase I TagA 0.0343 0.1746 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0322 0.1633 1
Entamoeba histolytica adenosine deaminase, putative 0.0267 0.1333 0.975
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0077 0.0306 0.1872
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0105 0.0765
Echinococcus granulosus orexin receptor type 2 0.0052 0.0166 0.044
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0476 0.3018
Brugia malayi sulfakinin receptor protein 0.0052 0.0166 0.044
Echinococcus granulosus fmrfamide receptor 0.0052 0.0166 0.044
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0166 0.044
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0289 0.1453 0.8834
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0322 0.1633 0.6499
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0054 0.0178 0.047
Trypanosoma brucei AMP deaminase, putative 0.0087 0.0358 0.1725
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.014 0.0648 0.3683
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0476 0.2697
Trypanosoma brucei polo-like protein kinase 0.0109 0.0476 0.2492
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0458 0.121
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0077 0.0306 0.1715
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0077 0.0306 0.0808
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0166 0.044
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0476 0.2697
Onchocerca volvulus 0.0052 0.0166 0.1248
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0166 0.044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0092 0.0244
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0306 0.0808
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0008 0.0008
Loa Loa (eye worm) RecQ helicase 0.0022 0.0008 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Onchocerca volvulus 0.0038 0.0093 0.0698
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0113 0.0605
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Entamoeba histolytica hypothetical protein 0.0077 0.0306 0.1677
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0166 0.044
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0223 0.059
Chlamydia trachomatis endonuclease IV 0.008 0.0319 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.014 0.0648 0.4747
Onchocerca volvulus 0.0052 0.0166 0.1248
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0266 0.0703
Echinococcus granulosus geminin 0.0176 0.0842 0.2225
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0058 0.0058
Schistosoma mansoni kinase 0.0055 0.0187 0.0494
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0113 0.0212
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0087 0.0358 0.1792
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0266 0.0266
Brugia malayi hypoxia-induced factor 1 0.0159 0.0747 0.1975
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Brugia malayi Pre-SET motif family protein 0.0219 0.1076 0.2844
Loa Loa (eye worm) DOMON domain-containing protein 0.0071 0.027 0.0715
Plasmodium falciparum phosphodiesterase delta, putative 0.014 0.0648 0.4747
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.014 0.0648 0.1712
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0036 0.008 0.0116
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0054 0.0178 0.0672
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.008 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.004 0.0105 0.0084
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0113 0.0605
Onchocerca volvulus 0.0071 0.027 0.203
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.0166 0.1248
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0166 0.044
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0052 0.0136
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0084 0.0222
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0903 0.0903
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Schistosoma mansoni opsin-like receptor 0.0052 0.0166 0.044
Schistosoma mansoni hypothetical protein 0.0176 0.0842 0.2225
Giardia lamblia Phosphatidylinositol 4-kinase 0.0062 0.0224 0.0547
Schistosoma mansoni peptidylglycine monooxygenase 0.0369 0.1888 0.4992
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0077 0.0306 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Loa Loa (eye worm) hypothetical protein 0.0194 0.094 0.2484
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0166 0.044
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0113 0.0605
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 0.0166 0.044
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.014 0.0648 0.3683
Schistosoma mansoni opsin-like receptor 0.0052 0.0166 0.044
Trypanosoma cruzi AMP deaminase, putative 0.0087 0.0358 0.1887
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Giardia lamblia hypothetical protein 0.014 0.0648 0.2305
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Plasmodium vivax sentrin-specific protease 1, putative 0.0054 0.0178 0.1089
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.1238 0.1238
Schistosoma mansoni neuropeptide receptor 0.0052 0.0166 0.044
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0077 0.0306 0.0306
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0077 0.0306 0.1715
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0166 0.044
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0038 0.0092 0.0566
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0038 0.0092 0.0244
Schistosoma mansoni amine GPCR 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0166 0.044
Loa Loa (eye worm) hypoxia-induced factor 1 0.0159 0.0747 0.1975
Leishmania major phosphatidylinositol 4-kinase, putative 0.0062 0.0224 0.0928
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0903 0.0903
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0273 0.1365 0.7806
Schistosoma mansoni hypothetical protein 0.0071 0.0269 0.0712
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0306 0.1677
Mycobacterium ulcerans putative regulatory protein 0.0077 0.0304 0.1735
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0437 0.2252 0.5954
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0092 0.0244
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0203 0.0203
Leishmania major AMP deaminase, putative 0.0087 0.0358 0.1792
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0166 0.044
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0038 0.0092 0.0244
Onchocerca volvulus 0.0052 0.0166 0.1248
Echinococcus multilocularis geminin 0.0176 0.0842 0.0842
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0181 0.0866 0.4937
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0166 0.0166
Onchocerca volvulus 0.0052 0.0166 0.1248
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0077 0.0306 0.1552
Echinococcus granulosus GPCR family 2 0.0036 0.0084 0.0222
Schistosoma mansoni survival motor neuron protein 0.0051 0.0163 0.0431
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0166 0.0166
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0077 0.0306 0.1552
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0222
Mycobacterium leprae PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.017 0.0809 0.5927
Treponema pallidum adenosine deaminase 0.0267 0.1333 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Leishmania major adenine aminohydrolase 0.0267 0.1333 0.8066
Plasmodium vivax SET domain protein, putative 0.0031 0.0058 0.0354
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.014 0.0648 0.2531
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0223 0.1098 0.1098
Onchocerca volvulus 0.0052 0.0166 0.1248
Brugia malayi hypothetical protein 0.0032 0.0062 0.0163
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0329 0.1671 0.9571
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0693 0.3943
Brugia malayi neuropeptide F receptor 0.0052 0.0166 0.044
Schistosoma mansoni neuropeptide receptor 0.0052 0.0166 0.044
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0255 0.1268 0.3351
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Schistosoma mansoni hypothetical protein 0.0052 0.0166 0.044
Plasmodium falciparum cGMP-specific phosphodiesterase 0.014 0.0648 0.4747
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.014 0.0648 0.3967
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.014 0.0648 0.4747
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0267 0.1333 0.5289
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0273 0.1365 0.8291
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0113 0.0298
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0084 0.0222
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0476 0.2638
Echinococcus multilocularis aryl hydrocarbon receptor 0.0036 0.008 0.008
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0273 0.1365 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0038 0.0092 0.008
Schistosoma mansoni adenosylhomocysteinase 0.0169 0.0802 0.2119
Echinococcus granulosus AMP deaminase 2 0.0087 0.0358 0.0947
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0166 0.0166
Echinococcus multilocularis allatostatin A receptor 0.0052 0.0166 0.0166
Mycobacterium ulcerans endonuclease IV 0.008 0.0319 0.1823
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0036 0.008 0.0211
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0109 0.048 0.2662
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0255 0.1268 0.1268
Echinococcus granulosus somatostatin receptor 0.0052 0.0166 0.044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0092 0.0244
Loa Loa (eye worm) hypothetical protein 0.0115 0.0509 0.1346
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0223 0.059
Trypanosoma cruzi AMP deaminase 2, putative 0.0087 0.0358 0.1887
Echinococcus granulosus g protein coupled receptor 0.0052 0.0166 0.044
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0166 0.044
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0336 0.1709 0.4519
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0166 0.044
Leishmania major phosphatidylinositol kinase related protein, putative 0.0038 0.0092 0.008
Onchocerca volvulus AMP deaminase 2 homolog 0.0087 0.0358 0.2688
Loa Loa (eye worm) hypothetical protein 0.0078 0.0312 0.0826
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.014 0.0648 0.1712
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1453 0.8317
Schistosoma mansoni single-minded 0.0074 0.0286 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Brugia malayi RE15519p 0.0052 0.0166 0.044
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0289 0.1453 0.8856
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0266 0.0703
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0054 0.0178 0.047
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0166 0.0166
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0038 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Echinococcus multilocularis muscleblind protein 0.0344 0.175 0.175
Leishmania major hypothetical protein, conserved 0.014 0.0648 0.3656
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0719 0.3783 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0476 0.1259
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0113 0.0113
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0166 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0308 0.1557 0.4115
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0329 0.1671 0.9571
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0343 0.1746 1
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0476 0.2697
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0476 0.2552
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0458 0.0458
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.014 0.0648 0.3683
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0289 0.1453 0.8856
Brugia malayi adenosine monophosphate deaminase 0.0087 0.0358 0.0947
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0266 0.1944
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0038 0.0092 0.0195
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0483 0.2503 0.6615
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0163 0.0431
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) phosphatidylinositol 3 0.0223 0.1098 0.2902
Schistosoma mansoni alpha glucosidase 0.0042 0.0113 0.0298
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Plasmodium vivax adenosine/AMP deaminase, putative 0.0087 0.0358 0.2193
Schistosoma mansoni lipoxygenase 0.0058 0.0203 0.0536
Echinococcus granulosus sentrin specific protease 1 0.0054 0.0178 0.047
Schistosoma mansoni aryl hydrocarbon receptor 0.0074 0.0286 0.0755
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0092 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0179 0.0986
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0036 0.008 0.0416
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0077 0.0306 0.1552
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0054 0.0178 0.0639
Schistosoma mansoni histamine h1 receptor 0.0052 0.0166 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0693 0.3943
Entamoeba histolytica adenosylhomocysteinase, putative 0.0273 0.1365 1
Toxoplasma gondii hypothetical protein 0.0149 0.0693 0.2713
Schistosoma mansoni hypothetical protein 0.0176 0.0842 0.2225
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0166 0.044
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0038 0.0092 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0476 0.1259
Echinococcus granulosus single minded 2 0.0038 0.0093 0.0246
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1453 0.8317
Brugia malayi AKH receptor 0.0052 0.0166 0.044
Schistosoma mansoni hypothetical protein 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0166 0.044
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0476 0.2697
Brugia malayi hypothetical protein 0.0194 0.094 0.2484
Onchocerca volvulus 0.0087 0.0358 0.2688
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Echinococcus granulosus neuropeptide receptor 0.0052 0.0166 0.044
Loa Loa (eye worm) hypothetical protein 0.008 0.0319 0.0843
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0577 0.3013 0.7964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Echinococcus granulosus dnaJ subfamily C 6 0.0071 0.0269 0.0712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0648 0.3729
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0289 0.1453 0.8317
Brugia malayi hypothetical protein 0.0052 0.0166 0.044
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0255 0.1268 0.9291
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0166 0.0166
Brugia malayi Dopamine receptor protein 2 0.0052 0.0166 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0038 0.0092 0.0195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0458 0.0458
Toxoplasma gondii adenosylhomocysteinase, putative 0.0273 0.1365 0.5418
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0166 0.044
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0036 0.008 0.0116
Brugia malayi follicle stimulating hormone receptor 0.0052 0.0166 0.044
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.0166 0.044
Plasmodium falciparum adenosine deaminase 0.0267 0.1333 0.9767
Mycobacterium tuberculosis Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.017 0.0809 0.5927
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0322 0.1633 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0166 0.044
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0322 0.1633 0.1633
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0039 0.0101 0.0248
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0306 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0092 0.0488
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0308 0.1557 0.4115
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0217 0.1064 0.6078
Echinococcus granulosus sex peptide receptor 0.0052 0.0166 0.044
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0166 0.0166
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0166 0.044
Echinococcus granulosus neuropeptide receptor 0.0052 0.0166 0.044
Brugia malayi larval opioid receptor 0.0052 0.0166 0.044
Schistosoma mansoni amine GPCR 0.0052 0.0166 0.044
Trichomonas vaginalis adenosine deaminase, putative 0.0267 0.1333 0.7623
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.044
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0266 0.1519

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 23 uM Binding affinity to Tsg101 (unknown origin) ChEMBL. 18083557
IC50 (binding) = 23 uM Binding affinity to Tsg101 (unknown origin) ChEMBL. 18083557

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.