Detailed information for compound 507744

Basic information

Technical information
  • TDR Targets ID: 507744
  • Name: [1-(2H-tetrazol-5-ylmethyl)cyclohexyl]methana mine
  • MW: 195.265 | Formula: C9H17N5
  • H donors: 2 H acceptors: 3 LogP: 1.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC1(CCCCC1)Cc1nnn[nH]1
  • InChi: 1S/C9H17N5/c10-7-9(4-2-1-3-5-9)6-8-11-13-14-12-8/h1-7,10H2,(H,11,12,13,14)
  • InChiKey: OHNKRFQIDUFFNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-(2H-1,2,3,4-tetrazol-5-ylmethyl)cyclohexyl]methanamine
  • [1-(2H-tetrazol-5-ylmethyl)cyclohexyl]methylamine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Voltage-dependent calcium channel alpha2delta subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus voltage dependent calcium channel subunit Get druggable targets OG5_133164 All targets in OG5_133164
Echinococcus multilocularis voltage dependent calcium channel subunit Get druggable targets OG5_133164 All targets in OG5_133164
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Voltage-dependent calcium channel alpha2delta subunit   1091 aa 1175 aa 23.9 %
Brugia malayi Cache domain containing protein Voltage-dependent calcium channel alpha2delta subunit   1091 aa 1135 aa 23.6 %
Echinococcus multilocularis voltage dependent calcium channel subunit Voltage-dependent calcium channel alpha2delta subunit   1091 aa 999 aa 24.6 %
Echinococcus granulosus voltage dependent calcium channel subunit Voltage-dependent calcium channel alpha2delta subunit   1091 aa 1023 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.1101 0.2809
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0048 0.5
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0179 0.1826 0.187
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0075 0.0081
Plasmodium falciparum cyclin 0.0019 0.0098 0.0063
Loa Loa (eye worm) hypothetical protein 0.0037 0.0294 0.0653
Trypanosoma cruzi cyclin 6, putative 0.0037 0.0294 0.0653
Loa Loa (eye worm) hypothetical protein 0.0119 0.1179 0.3009
Schistosoma mansoni hypothetical protein 0.0075 0.0695 0.0728
Trichomonas vaginalis protein kinase atmrk1, putative 0.0017 0.0075 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0048 0.5
Trypanosoma brucei mitotic cyclin 6 0.0037 0.0294 0.0653
Echinococcus multilocularis cyclins 0.0019 0.0098 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0199 0.2037 0.5293
Echinococcus multilocularis dual specificity 0.0112 0.1101 0.1057
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0179 0.1826 0.4732
Brugia malayi Cytochrome P450 family protein 0.0024 0.0146 0.026
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0017 0.0075 0.007
Giardia lamblia Cyclin A 0.0019 0.0098 0.0063
Echinococcus multilocularis cyclin dependent kinase 1 0.0179 0.1826 0.1786
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0294 0.0653
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0366 0.0845
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0017 0.0075 0.0028
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0366 0.0856
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0238 0.0249
Plasmodium vivax SET domain protein, putative 0.0032 0.0238 0.0439
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0112 0.1101 0.2801
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0112 0.1101 0.2801
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1387 0.1452
Echinococcus multilocularis dual specificity 0.0112 0.1101 0.1057
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trypanosoma cruzi cyclin, putative 0.0037 0.0294 0.0653
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1387 0.1452
Entamoeba histolytica protein kinase domain containing protein 0.0199 0.2037 0.5315
Leishmania major cytochrome p450-like protein 0.0024 0.0146 0.026
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.2772 0.7252
Echinococcus granulosus cyclin dependent kinase 5 0.0179 0.1826 0.187
Schistosoma mansoni cyclin B 0.0037 0.0294 0.0308
Echinococcus granulosus cyclin B3 1 0.0019 0.0098 0.0052
Brugia malayi Protein kinase domain containing protein 0.0017 0.0075 0.007
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0078 0.0732 0.0767
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0071 0.0024
Echinococcus granulosus cyclins 0.0019 0.0098 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0179 0.1826 0.4732
Loa Loa (eye worm) hypothetical protein 0.0032 0.0238 0.0506
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0238 0.0191
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0366 0.0781
Trichomonas vaginalis cyclins, putative 0.0028 0.0188 0.0381
Trichomonas vaginalis CMGC family protein kinase 0.0199 0.2037 0.5298
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0355 0.3719 0.3689
Plasmodium vivax glycogen synthase kinase 3, putative 0.0199 0.2037 0.526
Giardia lamblia Kinase, CMGC GSK 0.0199 0.2037 0.526
Echinococcus multilocularis dual specificity protein kinase clk2 0.0363 0.3805 0.3775
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0179 0.1826 0.4732
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0146 0.026
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0179 0.1826 0.4732
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0406 0.0951
Echinococcus granulosus dual specificity 0.0359 0.3767 0.3912
Plasmodium vivax protein kinase Crk2 0.0179 0.1826 0.4695
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0199 0.2037 0.5293
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0199 0.2037 0.5293
Echinococcus granulosus cyclin b3 0.0019 0.0098 0.0052
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0199 0.2037 0.2092
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0363 0.3805 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0359 0.3767 0.9898
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.2772 0.7252
Trichomonas vaginalis cyclin D, putative 0.0019 0.0098 0.0143
Entamoeba histolytica hypothetical protein 0.0036 0.0275 0.0542
Trypanosoma cruzi cdc2-related kinase 3 0.0179 0.1826 0.4732
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Entamoeba histolytica hypothetical protein 0.0036 0.0275 0.0542
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0075 0.0081
Brugia malayi Pre-SET motif family protein 0.0032 0.0238 0.0506
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0048 0.5
Brugia malayi RNA binding protein 0.0139 0.1387 0.3563
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0112 0.1101 0.2801
Echinococcus granulosus dual specificity 0.0112 0.1101 0.1107
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0363 0.3805 1
Trichomonas vaginalis CMGC family protein kinase 0.0017 0.0075 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.011 0.0164
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.1826 0.4738
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0695 0.1722
Echinococcus multilocularis cyclin b3 0.0019 0.0098 0.005
Loa Loa (eye worm) RNA binding protein 0.0139 0.1387 0.3563
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0179 0.1826 0.4732
Trichomonas vaginalis CMGC family protein kinase 0.0017 0.0075 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Loa Loa (eye worm) acetyltransferase 0.015 0.1507 0.3884
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.2772 0.7252
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.1826 0.4738
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0249 0.2582 0.2665
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0048 0.5
Brugia malayi MH2 domain containing protein 0.0118 0.1166 0.2974
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0017 0.0075 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Entamoeba histolytica cyclin, putative 0.0019 0.0098 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0146 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0363 0.3805 1
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.1507 0.3884
Loa Loa (eye worm) hypothetical protein 0.0064 0.058 0.1416
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Echinococcus multilocularis cyclins 0.0019 0.0098 0.005
Trypanosoma cruzi CYC2-like cyclin, putative 0.0037 0.0294 0.0653
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1068 0.2714
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0179 0.1826 0.4732
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trichomonas vaginalis cyclins, putative 0.0037 0.0294 0.0664
Trichomonas vaginalis cyclin B, putative 0.0037 0.0294 0.0664
Echinococcus granulosus dual specificity 0.0112 0.1101 0.1107
Schistosoma mansoni cyclin B3 0.0019 0.0098 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Echinococcus multilocularis protein kinase shaggy 0.0199 0.2037 0.1998
Schistosoma mansoni cyclins 0.0019 0.0098 0.0103
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.7589 0.7577
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0359 0.3767 0.9898
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0048 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Loa Loa (eye worm) hypothetical protein 0.0119 0.1179 0.3009
Brugia malayi hypothetical protein 0.0119 0.1179 0.3009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0366 0.0845
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0146 0.026
Entamoeba histolytica protein kinase, putative 0.0359 0.3767 1
Echinococcus granulosus cyclins 0.0019 0.0098 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0146 0.026
Trichomonas vaginalis cyclin B, putative 0.0037 0.0294 0.0664
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0071 0.0023
Echinococcus granulosus cyclins 0.0019 0.0098 0.0052
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0139 0.1387 0.3563
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0112 0.1101 0.2801
Entamoeba histolytica cyclin family protein 0.0019 0.0098 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0146 0.026
Schistosoma mansoni hypothetical protein 0.0035 0.0263 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.1826 0.1912
Trypanosoma brucei cdc2-related kinase 1 0.0179 0.1826 0.4732
Giardia lamblia Kinase, CMGC CLK 0.0363 0.3805 1
Onchocerca volvulus Phospholipase A2 homolog 0.0064 0.058 0.1481
Schistosoma mansoni cytochrome P450 0.0015 0.0048 0.0051
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2416 0.2379
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0155 0.1561 0.1634
Echinococcus multilocularis dual specificity 0.0112 0.1101 0.1057
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0363 0.3805 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0048 0.5
Onchocerca volvulus Phospholipase A2 homolog 0.0064 0.058 0.1481
Loa Loa (eye worm) hypothetical protein 0.0252 0.2607 0.6812
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0017 0.0075 0.007
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0037 0.0294 0.0653
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0075 0.0081
Leishmania major protein kinase, putative 0.0363 0.3805 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0238 0.0506
Echinococcus granulosus cyclin dependent kinase 0.0179 0.1826 0.187
Trypanosoma brucei cdc2-related kinase 3 0.0179 0.1826 0.4732
Echinococcus multilocularis cyclins 0.0019 0.0098 0.005
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0071 0.0023
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0048 0.5
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.2772 0.7248
Brugia malayi RNA recognition motif domain containing protein 0.0139 0.1387 0.3563
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0263 0.0571
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Brugia malayi Protein kinase domain containing protein 0.0359 0.3767 0.9898
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0071 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0211 0.0171
Loa Loa (eye worm) hypothetical protein 0.0018 0.0086 0.0101
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.7589 0.7944
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0053 0.0464 0.1106
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0464 0.1054
Echinococcus granulosus microtubule associated protein 2 0.0713 0.7589 0.7934
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0048 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Echinococcus multilocularis neuropeptide receptor A26 0.0478 0.5049 0.5025
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0019 0.0098 0.005
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.1781 0.6679
Trichomonas vaginalis cyclins, putative 0.0019 0.0098 0.0143
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0048 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1781 0.4617
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0199 0.2037 0.5293
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1387 0.1452
Schistosoma mansoni hypothetical protein 0.0015 0.0048 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0075 0.0078
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0048 0.5
Brugia malayi Phospholipase A2 family protein 0.0064 0.058 0.1416
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.1228 0.3139
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Brugia malayi hypothetical protein 0.0036 0.0275 0.0603
Echinococcus granulosus cyclin dependent kinase 9 0.0061 0.0546 0.0524
Loa Loa (eye worm) hypothetical protein 0.0075 0.0695 0.1722
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0017 0.0075 0.0026
Echinococcus multilocularis cyclins 0.0019 0.0098 0.005
Brugia malayi hypothetical protein 0.0234 0.2416 0.6303
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.1462 0.1487
Schistosoma mansoni kinase 0.0053 0.0464 0.0485
Giardia lamblia G2/mitotic-specific cyclin B 0.0037 0.0294 0.0587
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0075 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0048 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Entamoeba histolytica protein kinase, putative 0.0359 0.3767 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.1507 0.1466
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0113 0.0065
Onchocerca volvulus 0.0037 0.0294 0.024
Echinococcus granulosus hypothetical protein 0.0353 0.3704 0.3846
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0048 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0071 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.2772 0.7252
Brugia malayi TAR-binding protein 0.0139 0.1387 0.3563
Schistosoma mansoni hypothetical protein 0.0036 0.0275 0.0288
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.2772 0.7248
Mycobacterium leprae putative cytochrome p450 0.0015 0.0048 0.5
Loa Loa (eye worm) hypothetical protein 0.0234 0.2416 0.6303
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0048 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1387 0.1452
Echinococcus granulosus voltage dependent calcium channel subunit 0.0161 0.1632 0.1666
Entamoeba histolytica hypothetical protein 0.0036 0.0275 0.0542
Trichomonas vaginalis cyclins, putative 0.0037 0.0294 0.0664
Plasmodium falciparum protein serine/threonine kinase-1 0.0363 0.3805 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2227 0.5799
Echinococcus granulosus GPCR family 2 0.0035 0.0263 0.0226
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0263 0.0226
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0363 0.3805 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.058 0.1416
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0294 0.0653
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0363 0.3805 1
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1387 0.1452
Trypanosoma brucei protein kinase, putative 0.0199 0.2037 0.5293
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0017 0.0075 0.007
Trichomonas vaginalis cyclin B3, putative 0.0019 0.0098 0.0143
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0249 0.2582 0.2702
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1166 0.2974
Entamoeba histolytica cyclin family protein 0.0019 0.0098 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0238 0.0249
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.1826 0.1912
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0075 0.0081
Trypanosoma cruzi cdc2-related kinase 1 0.0179 0.1826 0.4732
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1781 0.4617
Echinococcus granulosus cyclin dependent kinase 1 0.0179 0.1826 0.187
Loa Loa (eye worm) hypothetical protein 0.0353 0.3704 0.973
Loa Loa (eye worm) hypothetical protein 0.0037 0.0294 0.0653
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0161 0.1632 0.1591
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0048 0.5
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0363 0.3805 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0146 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1068 0.2714
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.2772 0.7252
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.2772 0.7252
Echinococcus granulosus cyclin B 0.0037 0.0294 0.0258
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.1826 0.4738
Leishmania major protein kinase, putative 0.0363 0.3805 1
Brugia malayi Protein kinase domain containing protein 0.0179 0.1826 0.4732
Brugia malayi Protein kinase domain containing protein 0.0363 0.3805 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0366 0.0856
Schistosoma mansoni hypothetical protein 0.0035 0.0263 0.0275
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0112 0.1101 0.2801
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0464 0.0485
Brugia malayi cyclin-dependent kinase 7 homolog 0.0017 0.0075 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.1101 0.2809
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0238 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0017 0.0075 0.007
Trichomonas vaginalis serine/threonine kinase, putative 0.0017 0.0075 0.0081
Onchocerca volvulus 0.0048 0.0406 0.0725
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0199 0.2037 0.5293
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0019 0.0098 0.0052
Echinococcus multilocularis cyclins 0.0019 0.0098 0.005
Echinococcus multilocularis neuropeptide s receptor 0.0478 0.5049 0.5025
Echinococcus multilocularis dnaJ subfamily B 0.0895 0.9553 0.9551
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0017 0.0075 0.007
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0329 0.3436 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0661 0.1632
Trichomonas vaginalis CMGC family protein kinase 0.0017 0.0075 0.0081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1068 0.2714
Entamoeba histolytica protein kinase, putative 0.0199 0.2037 0.5315
Brugia malayi Pre-SET motif family protein 0.0217 0.2227 0.5799
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0263 0.0571
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0238 0.0191
Trichomonas vaginalis cyclins, putative 0.0037 0.0294 0.0664
Echinococcus multilocularis cyclins 0.0019 0.0098 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0048 0.5
Schistosoma mansoni serine/threonine kinase 0.0017 0.0075 0.0078
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2548 0.6657
Schistosoma mansoni cpg binding protein 0.0066 0.0608 0.0636
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1883 0.4888
Schistosoma mansoni protein kinase 0.0017 0.0075 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0017 0.0075 0.0081
Giardia lamblia Hypothetical protein 0.0019 0.0098 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Echinococcus granulosus voltage dependent calcium channel subunit 0.0355 0.3719 0.3862
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0098 0.0143
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0359 0.3767 0.9898
Echinococcus granulosus dual specificity protein kinase clk2 0.0363 0.3805 0.3953
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0474 0.1133
Onchocerca volvulus 0.0246 0.2548 1
Trypanosoma cruzi cdc2-related kinase 1 0.0179 0.1826 0.4732
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0199 0.2037 0.2132
Brugia malayi cell division control protein 2 homolog 0.0179 0.1826 0.4732
Loa Loa (eye worm) TAR-binding protein 0.0139 0.1387 0.3563
Giardia lamblia Kinase, CMGC GSK 0.0199 0.2037 0.526
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Schistosoma mansoni hypothetical protein 0.0035 0.0263 0.0275
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0263 0.0226
Loa Loa (eye worm) hypothetical protein 0.0249 0.2582 0.6743
Echinococcus multilocularis dual specificity 0.0359 0.3767 0.3737
Trichomonas vaginalis cyclin D, putative 0.0019 0.0098 0.0143
Schistosoma mansoni hypothetical protein 0.0895 0.9553 1
Echinococcus granulosus cpg binding protein 0.0066 0.0608 0.0588
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0263 0.0216
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0017 0.0075 0.0026
Echinococcus granulosus mitogen activated protein kinase 15 0.0017 0.0075 0.0028
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0146 0.026
Schistosoma mansoni survival motor neuron protein 0.0048 0.0406 0.0425
Loa Loa (eye worm) hypothetical protein 0.035 0.3665 0.9628
Schistosoma mansoni serine/threonine protein kinase 0.0359 0.3767 0.3943
Schistosoma mansoni hypothetical protein 0.0035 0.0263 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0275 0.0238
Onchocerca volvulus 0.0199 0.2037 0.7788
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0571
Loa Loa (eye worm) haspin protein kinase 0.0017 0.0075 0.007
Echinococcus granulosus cyclin dependent kinase 9 0.0053 0.0464 0.0437
Schistosoma mansoni cpg binding protein 0.0066 0.0608 0.0636
Echinococcus granulosus cyclins 0.0019 0.0098 0.0052
Leishmania major serine/threonine kinase-like protein, putative 0.0017 0.0075 0.007
Brugia malayi cyclin-dependent kinase 9 0.0053 0.0464 0.1106
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1883 0.4888
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0113 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1781 0.4617
Plasmodium vivax serine/threonine kinase-1, putative 0.0363 0.3805 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0238 0.0249
Echinococcus multilocularis cyclin B3 1 0.0019 0.0098 0.005
Echinococcus multilocularis cyclin dependent kinase 9 0.0053 0.0464 0.0417
Trichomonas vaginalis CMGC family protein kinase 0.0199 0.2037 0.5298
Entamoeba histolytica hypothetical protein 0.0359 0.3767 1
Echinococcus granulosus neuropeptide s receptor 0.0478 0.5049 0.5262
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0275 0.0227
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0048 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0275 0.0288
Trichomonas vaginalis cyclin B, putative 0.0037 0.0294 0.0664
Schistosoma mansoni serine-rich repeat protein 0.0083 0.079 0.0827
Loa Loa (eye worm) cyclin domain-containing protein 0.0019 0.0098 0.0132
Entamoeba histolytica hypothetical protein 0.0036 0.0275 0.0542
Schistosoma mansoni hypothetical protein 0.0083 0.079 0.0827
Entamoeba histolytica cell division protein kinase 2, putative 0.0179 0.1826 0.4744
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0263 0.0571
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1781 0.4617
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0048 0.5
Echinococcus multilocularis cyclin dependent kinase 9 0.0061 0.0546 0.0501
Echinococcus granulosus cyclins 0.0019 0.0098 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Loa Loa (eye worm) hypothetical protein 0.017 0.1725 0.4462
Entamoeba histolytica cyclin, putative 0.0037 0.0294 0.0594
Schistosoma mansoni hypothetical protein 0.0048 0.0406 0.0425
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0326 0.0682
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Echinococcus granulosus tar DNA binding protein 0.0139 0.1387 0.1408
Echinococcus multilocularis cpg binding protein 0.0066 0.0608 0.0562
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0113 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0263 0.0216
Echinococcus multilocularis cyclin dependent kinase 5 0.0179 0.1826 0.1786
Trichomonas vaginalis cyclins, putative 0.0037 0.0294 0.0664
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1781 0.4617
Schistosoma mansoni serine/threonine protein kinase 0.0363 0.3805 0.3983
Trichomonas vaginalis cyclin B, putative 0.0037 0.0294 0.0664
Echinococcus multilocularis cyclin dependent kinase 0.0179 0.1826 0.1786
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0075 0.0081
Echinococcus multilocularis 0.0353 0.3704 0.3673
Trypanosoma brucei protein kinase, putative 0.0017 0.0075 0.007
Schistosoma mansoni cpg binding protein 0.0063 0.0569 0.0596
Brugia malayi Cytochrome P450 family protein 0.0054 0.0474 0.1133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.1342 0.1405
Echinococcus granulosus dnaJ subfamily B 0.0895 0.9553 1
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0075 0.0081
Loa Loa (eye worm) hypothetical protein 0.035 0.3665 0.9628
Trichomonas vaginalis CMGC family protein kinase 0.0017 0.0075 0.0081
Plasmodium falciparum protein kinase 5 0.0179 0.1826 0.4695
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.1101 0.2809
Loa Loa (eye worm) hypothetical protein 0.0109 0.1068 0.2714
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1781 0.4617
Echinococcus granulosus protein kinase shaggy 0.0199 0.2037 0.2092
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1781 0.4617
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Giardia lamblia Kinase, CMGC CDK 0.0179 0.1826 0.4695
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0363 0.3805 1
Entamoeba histolytica protein kinase domain containing protein 0.0359 0.3767 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0048 0.5
Trichomonas vaginalis cyclin B, putative 0.0019 0.0098 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.1101 0.1152
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.1101 0.2809
Trypanosoma cruzi cdc2-related kinase 3 0.0179 0.1826 0.4732
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.1101 0.2809
Echinococcus multilocularis GPCR, family 2 0.0035 0.0263 0.0216
Brugia malayi Cyclin, N-terminal domain containing protein 0.0019 0.0098 0.0132
Brugia malayi CXXC zinc finger family protein 0.0063 0.0569 0.1385
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0326 0.0675
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0238 0.0249
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0359 0.3767 0.9898
Brugia malayi intracellular kinase 0.0199 0.2037 0.5293
Echinococcus granulosus serine:threonine protein kinase NLK 0.0017 0.0075 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.1101 0.2809
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Brugia malayi Cache domain containing protein 0.0071 0.0661 0.1632
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0048 0.5
Entamoeba histolytica protein kinase, putative 0.0112 0.1101 0.2779
Giardia lamblia Kinase, CMGC CDK 0.0179 0.1826 0.4695
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0048 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0363 0.3805 0.3983
Echinococcus granulosus neuropeptide receptor A26 0.0478 0.5049 0.5262
Entamoeba histolytica protein kinase domain containing protein 0.0199 0.2037 0.5315
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0199 0.2037 0.1998
Brugia malayi Cytochrome P450 family protein 0.0024 0.0146 0.026
Entamoeba histolytica cell division protein kinase 2, putative 0.0187 0.1909 0.4968
Echinococcus multilocularis tar DNA binding protein 0.0139 0.1387 0.1345
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0326 0.0675
Trypanosoma cruzi cyclin, putative 0.0037 0.0294 0.0653
Echinococcus multilocularis cyclins 0.0019 0.0098 0.005
Onchocerca volvulus 0.0063 0.0569 0.1431
Echinococcus granulosus dual specificity 0.0112 0.1101 0.1107
Leishmania major cyclin 0.0037 0.0294 0.0653
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0048 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0569 0.1385
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0249 0.2582 0.2546
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0363 0.3805 1
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0112 0.1101 0.2801
Brugia malayi Cell division protein kinase 2 0.0017 0.0075 0.007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.1507 0.1578
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2416 0.2491
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0359 0.3767 0.9898
Trichomonas vaginalis cyclin A, putative 0.0037 0.0294 0.0664
Plasmodium falciparum glycogen synthase kinase 3 0.0199 0.2037 0.526
Giardia lamblia Kinase, CMGC DYRK 0.0112 0.1101 0.275
Echinococcus multilocularis cyclin dependent kinase 1 0.0179 0.1826 0.1786
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0366 0.0334
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0075 0.0081
Echinococcus multilocularis cyclin B 0.0037 0.0294 0.0247
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1166 0.2974
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.1101 0.2779
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0017 0.0075 0.007

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 80 % Protection against audiogenically induced tonic seizure in DBA/2 mouse at 30 mg/kg, po ChEMBL. 15946842
Activity (functional) = 80 % Protection against audiogenically induced tonic seizure in DBA/2 mouse at 30 mg/kg, po ChEMBL. 15946842
ED50 (functional) = 3.1 mg Kg-1 Potency in DBA/2 mouse anticonvulsant assay ChEMBL. 15946842
ED50 (functional) = 3.1 mg Kg-1 Potency in DBA/2 mouse anticonvulsant assay ChEMBL. 15946842
IC50 (binding) = 100 nM Displacement of [3H]gabapentin from alpha2-delta calcium channel in pig brain ChEMBL. 17489571
IC50 (binding) = 108 nM Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membrane ChEMBL. 15946842
IC50 (binding) = 108 nM Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membrane ChEMBL. 15946842

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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