Detailed information for compound 511152

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 442.338 | Formula: C23H21Cl2N3O2
  • H donors: 0 H acceptors: 3 LogP: 4.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCCC1c1cccnc1)c1cncc(c1)COc1c(Cl)cccc1Cl
  • InChi: 1S/C23H21Cl2N3O2/c24-19-6-3-7-20(25)22(19)30-15-16-11-18(14-27-12-16)23(29)28-10-2-1-8-21(28)17-5-4-9-26-13-17/h3-7,9,11-14,21H,1-2,8,10,15H2
  • InChiKey: DCDGQBAJMIITEP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0062 0.0302 0.0734
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0558 0.3233 0.3201
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0147 0.0207
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0066
Schistosoma mansoni tsg101-related 0.0046 0.0207 0.0291
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.4676 0.659
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0035
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0483 0.068
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.0014
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0249 0.4636
Trypanosoma brucei ISWI complex protein 0.0032 0.0123 0.2378
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.034 0.0479
Brugia malayi hypothetical protein 0.0035 0.0141 0.0327
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0212 0.0298
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0147 0.0343
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0249 0.2122
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0249 0.4636
Brugia malayi MH2 domain containing protein 0.0242 0.1361 0.376
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.003 0.0042
Schistosoma mansoni hypothetical protein 0.0287 0.1629 0.2295
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0249 0.4637
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0249 0.4637
Loa Loa (eye worm) MBCTL1 0.0054 0.025 0.0661
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0069 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0338 0.0915
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0249 0.0351
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0035
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0212 0.0298
Schistosoma mansoni cpg binding protein 0.0085 0.0436 0.0614
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0689 0.1891
Brugia malayi CXXC zinc finger family protein 0.0085 0.0436 0.1156
Mycobacterium ulcerans lipoprotein LpqF 0.0062 0.0302 0.08
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0689 0.1868
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0751
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0042
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0249 0.4637
Entamoeba histolytica hypothetical protein 0.0035 0.0141 0.2683
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0047 0.0003
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.034 0.6942
Brugia malayi RNA binding protein 0.0128 0.0689 0.1868
Schistosoma mansoni DNA polymerase eta 0.0019 0.0047 0.0066
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.048 0.0676
Schistosoma mansoni tsg101-related 0.0057 0.0268 0.0378
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0371
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0249 0.4636
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.048 0.0676
Echinococcus granulosus geminin 0.0166 0.0914 0.1288
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0483 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0057 0.0081
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0147 0.0207
Leishmania major hypothetical protein, conserved 0.0022 0.0061 0.0338
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0338 0.0915
Echinococcus granulosus dna polymerase eta 0.0019 0.0047 0.0066
Brugia malayi mbt repeat family protein 0.0047 0.0212 0.0526
Brugia malayi Smad1 0.0016 0.003 0.0014
Echinococcus multilocularis Kelch repeat type 1 0.0093 0.0481 0.0678
Loa Loa (eye worm) hypothetical protein 0.0082 0.0419 0.1135
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.1032 0.1454
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0145 0.0205
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0338 0.0476
Echinococcus multilocularis dna polymerase eta 0.0019 0.0047 0.0066
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.034 0.6972
Treponema pallidum replicative DNA helicase (dnaB) 0.0382 0.2193 1
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.048 0.0676
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0083 0.1521
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0088 0.0207
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0338 0.0476
Schistosoma mansoni ets-related 0.0215 0.1206 0.17
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0558 0.3233 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0035
Echinococcus granulosus tar DNA binding protein 0.0128 0.0689 0.097
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0483 1
Echinococcus granulosus GPCR family 2 0.0016 0.0025 0.0035
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0483 0.1842
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0249 0.4636
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0483 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0147 0.0207
Echinococcus granulosus Smad4 0.0016 0.003 0.0042
Schistosoma mansoni hypothetical protein 0.0032 0.0123 0.0174
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0147 0.0207
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0066
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0212 0.0298
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0249 0.0351
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0419 0.1109
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0212 0.0553
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0352 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Schistosoma mansoni hypothetical protein 0.0034 0.0132 0.0186
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0061
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.034 0.6726
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0057 0.0081
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0147 0.0207
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0147 0.2876
Schistosoma mansoni myst-related protein 0.0014 0.0016 0.0022
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0249 0.0657
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0224 0.0561
Brugia malayi Cytochrome P450 family protein 0.0051 0.0234 0.0587
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0047 0.0066
Brugia malayi hypothetical protein 0.0068 0.0335 0.0874
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.025 0.0353
Schistosoma mansoni cpg binding protein 0.0094 0.0488 0.0688
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0069 0.1233
Brugia malayi hypothetical protein 0.0296 0.1684 0.4668
Leishmania major hypothetical protein, conserved 0.0025 0.0083 0.0833
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0483 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.1684 0.4683
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0147 0.2297
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0088 0.0124
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.025 0.0353
Echinococcus granulosus neuropeptide s receptor 0.0462 0.2666 0.3757
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0203 0.0501
Entamoeba histolytica hypothetical protein 0.0035 0.0141 0.2683
Echinococcus granulosus kelch ECH associated protein 1 0.0093 0.048 0.0676
Brugia malayi MAP kinase sur-1 0.0053 0.0249 0.063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0203 0.0286
Brugia malayi PHD-finger family protein 0.0057 0.0272 0.0695
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0483 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0291 0.0776
Trichomonas vaginalis hypothetical protein 0.0033 0.0129 0.1886
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0153 0.0388
Echinococcus multilocularis cpg binding protein 0.0094 0.0488 0.0688
Schistosoma mansoni smad 0.0016 0.003 0.0042
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0042
Brugia malayi mbt repeat family protein 0.0047 0.0212 0.0526
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0203 0.0286
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.011 0.024
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0689 0.097
Loa Loa (eye worm) hypothetical protein 0.0054 0.025 0.0661
Trypanosoma cruzi ISWI complex protein 0.0032 0.0123 0.1759
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0689 0.097
Loa Loa (eye worm) hypothetical protein 0.0149 0.0815 0.2245
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.009
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0132 0.0301
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0062 0.0302 0.0256
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.1361 0.3778
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.025 0.0353
Brugia malayi hypothetical protein 0.0025 0.0083 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0689 0.097
Echinococcus multilocularis smad 0.0016 0.003 0.0042
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0352 0.0947
Trypanosoma brucei unspecified product 0.0019 0.0047 0.0751
Loa Loa (eye worm) fli-1 protein 0.0215 0.1206 0.3344
Echinococcus granulosus dnaJ subfamily B 0.1212 0.7097 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0156 0.022
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.003 0.0043
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0047 0.0066
Echinococcus granulosus muscleblind protein 0.0617 0.3578 0.5042
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0156 0.022
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.034 0.0479
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0035
Schistosoma mansoni Smad4 0.0016 0.003 0.0042
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.034 0.6726
Loa Loa (eye worm) hypothetical protein 0.0617 0.3578 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0047 0.0751
Toxoplasma gondii histone lysine methyltransferase SET1 0.0166 0.0915 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.003 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0751
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0061
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.003 0.0042
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0052 0.0242 0.0342
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.025 0.0634
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0141 0.0199
Brugia malayi hypothetical protein 0.0016 0.003 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0203 0.0286
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0382 0.2193 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0249 0.4636
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.0335 0.0473
Echinococcus granulosus cpg binding protein 0.0094 0.0488 0.0688
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0203 0.0286
Chlamydia trachomatis replicative DNA helicase 0.0382 0.2193 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0069 0.0071
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0381 0.0536
Loa Loa (eye worm) hypothetical protein 0.0081 0.0411 0.1113
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.2666 0.3757
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0057 0.0081
Onchocerca volvulus 0.0085 0.0436 0.1522
Entamoeba histolytica hypothetical protein 0.0035 0.0141 0.2683
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0689 0.097
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.003 0.0042
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0083 0.0161
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0035
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0207 0.4088
Schistosoma mansoni hypothetical protein 0.1212 0.7097 1
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0014
Brugia malayi Fli-1 protein 0.0215 0.1206 0.3325
Loa Loa (eye worm) RNA binding protein 0.0128 0.0689 0.1891
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0083 0.0833
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0083 0.0833
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0088 0.0124
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.1032 0.1454
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0083 1
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.013 0.0701 0.0658
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0147 0.2297
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0397
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.003 0.0043
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0047 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0206 0.3664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0156 0.022
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0483 0.068
Entamoeba histolytica hypothetical protein 0.0023 0.0069 0.1148
Trypanosoma brucei polo-like protein kinase 0.0093 0.0483 1
Loa Loa (eye worm) twinkle helicase 0.0109 0.0578 0.1582
Echinococcus multilocularis GPCR, family 2 0.0016 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0086 0.0441 0.1196
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0203 0.0529
Loa Loa (eye worm) hypothetical protein 0.0095 0.0493 0.1343
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.019 0.0492
Brugia malayi Muscleblind-like protein 0.0617 0.3578 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.1361 0.3778
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0014
Brugia malayi Bromodomain containing protein 0.0163 0.0897 0.2453
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0047 0.009
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.025 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0483 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0483 1
Brugia malayi Ets-domain containing protein 0.0071 0.0352 0.0921
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.034 0.0913
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0057 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0156 0.022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0025 0.0029
Echinococcus granulosus fetal alzheimer antigen falz 0.0052 0.0242 0.0342
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0249 0.4636
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0069 0.0023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0147 0.2299
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0558 0.3233 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0617 0.3578 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0047 0.0662
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0483 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0147 0.2299
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0483 0.1314
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0212 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0206 0.3664
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.013 0.0701 0.2055
Schistosoma mansoni bromodomain containing protein 0.0014 0.0015 0.0021
Echinococcus multilocularis dnaJ subfamily B 0.1212 0.7097 1
Entamoeba histolytica hypothetical protein 0.0035 0.0141 0.2683
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0061 0.0338
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0083 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0483 1
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0061 0.1064
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0249 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0689 0.097
Loa Loa (eye worm) Smad1 0.0016 0.003 0.0043
Schistosoma mansoni myst-related protein 0.0014 0.0016 0.0022
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0338 0.3177
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.034 0.6726
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0419 0.059
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Mycobacterium leprae Conserved hypothetical protein 0.0501 0.2895 0.8932
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.0335 0.0473
Schistosoma mansoni bromodomain containing protein 0.0138 0.075 0.1058
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0141 0.0199
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0419 0.059
Schistosoma mansoni gabp alpha 0.0071 0.0352 0.0496
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.2666 0.3757
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0381 0.0536
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0005 0.0007
Leishmania major hypothetical protein, conserved 0.0032 0.0123 0.1759
Brugia malayi TAR-binding protein 0.0128 0.0689 0.1868
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0689 0.097
Loa Loa (eye worm) hypothetical protein 0.0047 0.0212 0.0553
Echinococcus multilocularis Smad4 0.0016 0.003 0.0042
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0689 0.1891
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0249 0.0351
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0382 0.2193 0.6714
Echinococcus granulosus zinc finger protein 0.0046 0.0205 0.0289
Schistosoma mansoni kinase 0.0048 0.0214 0.0301
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0147 0.2299
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0147 0.2297
Schistosoma mansoni zinc finger protein 0.0046 0.0205 0.0289
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.003 0.0042
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0145 0.0205
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.025 0.0353
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0483 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0751
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.048 0.0676
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0147 0.2807
Trypanosoma brucei beta lactamase 0.0062 0.0302 0.6159
Schistosoma mansoni hypothetical protein 0.0166 0.0914 0.1288
Schistosoma mansoni cpg binding protein 0.0094 0.0488 0.0688
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0147 0.0207
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0352 0.0496
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0052 0.0242 0.0342
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0035
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0249 0.5038
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0249 0.4636
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0147 0.0207
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.018 0.0999 0.1408
Brugia malayi Bromodomain containing protein 0.0081 0.041 0.1085
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0382 0.2193 0.6737
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0338 0.0476
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0147 0.0207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0203 0.0286
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0057 0.0081
Schistosoma mansoni hypothetical protein 0.0166 0.0914 0.1288
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0047 0.0066
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0069 0.7976
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0224 0.0561
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0338 0.0915
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0234 0.0614
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0224 0.0588
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0249 0.4637
Giardia lamblia Kinase, PLK 0.0093 0.0483 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0483 0.1288
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0483 1
Echinococcus multilocularis muscleblind protein 0.0617 0.3578 0.5042
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.2666 0.3757
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0249 0.0351
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0436 0.1181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0203 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0203 0.0286
Schistosoma mansoni tsg101-related 0.0057 0.0268 0.0378
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0145 0.0205
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0147 0.2297
Schistosoma mansoni hypothetical protein 0.0035 0.0141 0.0199
Loa Loa (eye worm) hypothetical protein 0.0068 0.0335 0.09
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0419 0.059
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.034 0.0887
Loa Loa (eye worm) hypothetical protein 0.0034 0.0132 0.0329
Schistosoma mansoni Replicative DNA helicase 0.0382 0.2193 0.3091
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0141 0.0199
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0083 1
Brugia malayi Ets-domain containing protein 0.0071 0.0352 0.0921
Echinococcus multilocularis zinc finger protein 0.0046 0.0205 0.0289
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.0014
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.0706 0.0995
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0483 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0338 0.6683
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.034 0.0479
Loa Loa (eye worm) hypothetical protein 0.0049 0.0224 0.0588
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0212 0.0298
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.0706 0.0995
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1321 0.7739 0.7729
Echinococcus granulosus transcription factor Dp 1 0.004 0.0168 0.0237
Trypanosoma brucei protein kinase, putative 0.0053 0.0249 0.5038
Onchocerca volvulus 0.0296 0.1684 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0338 0.0293
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Echinococcus granulosus dna polymerase kappa 0.0019 0.0047 0.0066
Schistosoma mansoni zinc finger protein 0.0032 0.0123 0.0174
Trypanosoma cruzi ISWI complex protein 0.0032 0.0123 0.1759
Echinococcus multilocularis muscleblind protein 1 0.0617 0.3578 0.5042
Echinococcus multilocularis geminin 0.0166 0.0914 0.1288
Schistosoma mansoni hypothetical protein 0.0093 0.0481 0.0678
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0168 0.0237
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0042
Onchocerca volvulus 0.0082 0.0419 0.1409
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0069 0.0521
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0212 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0751
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0145 0.0205
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0212 0.0298
Echinococcus granulosus smad 0.0016 0.003 0.0042
Schistosoma mansoni hypothetical protein 0.0044 0.019 0.0268
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0338 0.0476

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2 nM Inhibition of human 11beta HSD in HEK293 cells by SPA method ChEMBL. 18485702

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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