Detailed information for compound 511241

Basic information

Technical information
  • TDR Targets ID: 511241
  • Name: N-[(2S,3S,4R)-3,4-dihydroxy-1-[(2S,3R,4S,5R,6 R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-y l]oxyoctadecan-2-yl]-3-[4-(trifluoromethyl)ph enyl]propanamide
  • MW: 679.805 | Formula: C34H56F3NO9
  • H donors: 7 H acceptors: 7 LogP: 6.08 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCCCCCCCCCCCC[C@H]([C@H]([C@@H](NC(=O)CCc1ccc(cc1)C(F)(F)F)CO[C@H]1O[C@H](CO)[C@@H]([C@@H]([C@H]1O)O)O)O)O
  • InChi: 1S/C34H56F3NO9/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-26(40)29(42)25(22-46-33-32(45)31(44)30(43)27(21-39)47-33)38-28(41)20-17-23-15-18-24(19-16-23)34(35,36)37/h15-16,18-19,25-27,29-33,39-40,42-45H,2-14,17,20-22H2,1H3,(H,38,41)/t25-,26+,27+,29-,30-,31-,32+,33-/m0/s1
  • InChiKey: YPGLRHMNEJQSFA-BAHUXPPRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1S,2S,3R)-2,3-dihydroxy-1-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxymethyl]heptadecyl]-3-[4-(trifluoromethyl)phenyl]propanamide
  • N-[(1S,2S,3R)-2,3-dihydroxy-1-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxymethyl]heptadecyl]-3-[4-(trifluoromethyl)phenyl]propanamide
  • N-[(2S,3S,4R)-3,4-dihydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-octadecan-2-yl]-3-[4-(trifluoromethyl)phenyl]propanamide
  • N-[(1S,2S,3R)-2,3-dihydroxy-1-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxymethyl]heptadecyl]-3-[4-(trifluoromethyl)phenyl]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi tubulin alpha chain - mouse 0.0423 0.2401 0.6672
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0119 0.0119
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.001 0.003
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.001 0.003
Trichomonas vaginalis tubulin beta chain, putative 0.0423 0.2401 0.7479
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0046 0.0195 0.0608
Leishmania major beta tubulin 0.0562 0.3211 1
Brugia malayi alpha-tubulin 0.0423 0.2401 0.6672
Trypanosoma brucei zeta tubulin, putative 0.0448 0.2545 0.7918
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0218 0.2733
Schistosoma mansoni alpha tubulin 0.0423 0.2401 0.7471
Echinococcus granulosus tubulin beta 1 chain 0.0562 0.3211 1
Schistosoma mansoni tubulin subunit beta 0.0145 0.0771 0.2379
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0219 0.0652
Brugia malayi Isocitrate dehydrogenase 0.0034 0.012 0.0306
Onchocerca volvulus 0.0072 0.0342 0.1901
Brugia malayi PAS domain containing protein 0.005 0.0219 0.0582
Entamoeba histolytica tubulin family protein 0.0562 0.3211 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0423 0.2401 0.2401
Giardia lamblia Beta tubulin 0.0562 0.3211 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0914 0.2543
Echinococcus granulosus Tubulin beta 2C chain 0.0562 0.3211 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0345 0.1942 0.6036
Schistosoma mansoni cpg binding protein 0.0033 0.0116 0.0333
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0046 0.0195 0.058
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Schistosoma mansoni tubulin subunit beta 0.0562 0.3211 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0423 0.2401 0.2401
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0218 0.065
Loa Loa (eye worm) hypothetical protein 0.0502 0.2862 0.7961
Echinococcus multilocularis lamin 0.0057 0.0258 0.0258
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.012 0.0343
Echinococcus granulosus Tubulin beta 2C chain 0.0562 0.3211 1
Schistosoma mansoni hypothetical protein 0.0102 0.0523 0.1602
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0258 0.0719
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0046 0.0195 0.2437
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.0399
Brugia malayi Tubulin gamma chain 0.0345 0.1945 0.5398
Echinococcus granulosus tubulin gamma 1 chain 0.0345 0.1945 0.6056
Brugia malayi intermediate filament protein 0.0057 0.0258 0.0694
Loa Loa (eye worm) tubulin beta-2A chain 0.0562 0.3211 0.8933
Leishmania major beta tubulin 0.0562 0.3211 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0247 0.0741
Plasmodium falciparum tubulin delta chain, putative 0.0145 0.0771 0.2379
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.012 0.0343
Loa Loa (eye worm) tubulin alpha 2 0.0278 0.1553 0.4321
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0119 0.0305
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0103 0.0259
Onchocerca volvulus 0.0037 0.0142 0.0787
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0003 0.0009
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0174 0.0941 0.2908
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0046 0.0195 0.058
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0142 0.0142
Schistosoma mansoni tubulin subunit beta 0.0562 0.3211 1
Echinococcus granulosus tubulin delta chain 0.0145 0.0771 0.2402
Leishmania major beta tubulin 0.0562 0.3211 1
Brugia malayi tubulin alpha-2 chain 0.0423 0.2401 0.6672
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0247 0.077
Echinococcus granulosus Tubulin alpha 1 chain 0.0423 0.2401 0.7479
Loa Loa (eye worm) hypothetical protein 0.0423 0.2401 0.6681
Trichomonas vaginalis tubulin, putative 0.0171 0.0925 0.288
Loa Loa (eye worm) alpha-tubulin 0.0423 0.2401 0.6681
Echinococcus multilocularis Tubulin beta 2C chain 0.0562 0.3211 0.3211
Echinococcus granulosus GPCR family 2 0.0033 0.0119 0.0371
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0027
Giardia lamblia Beta tubulin 0.0562 0.3211 1
Echinococcus multilocularis beta tubulin 0.0562 0.3211 0.3211
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Schistosoma mansoni alpha tubulin 0.0423 0.2401 0.7471
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0247 0.0247
Trypanosoma brucei epsilon tubulin 0.0345 0.1942 0.6036
Trypanosoma brucei alpha tubulin 0.0423 0.2401 0.7471
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0247 0.077
Loa Loa (eye worm) oxidoreductase 0.0015 0.001 0.0027
Trichomonas vaginalis tubulin beta chain, putative 0.0423 0.2401 0.7479
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0258 0.0719
Echinococcus granulosus tubulin subunit beta 0.0562 0.3211 1
Echinococcus granulosus tubulin alpha 3 chain 0.0423 0.2401 0.7479
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0143 0.1755
Trichomonas vaginalis tubulin alpha chain, putative 0.0171 0.0925 0.288
Trichomonas vaginalis tubulin, putative 0.0174 0.0943 0.2937
Schistosoma mansoni cpg binding protein 0.0031 0.0106 0.03
Echinococcus granulosus tubulin alpha chain 0.0423 0.2401 0.7479
Loa Loa (eye worm) hypothetical protein 0.0106 0.0543 0.151
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0523 0.1431
Schistosoma mansoni tubulin subunit gamma 0.0345 0.1945 0.6044
Trichomonas vaginalis tubulin epsilon chain, putative 0.0562 0.3211 1
Leishmania major delta tubulin, putative 0.0326 0.1832 0.5705
Echinococcus multilocularis tubulin alpha chain 0.0423 0.2401 0.2401
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0562 0.3211 0.3211
Schistosoma mansoni tubulin subunit alpha 0.0145 0.0771 0.2379
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0131 0.1597
Echinococcus granulosus single minded 2 0.0037 0.0142 0.0442
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0218 0.2733
Echinococcus multilocularis tubulin alpha 1C chain 0.0423 0.2401 0.2401
Schistosoma mansoni cpg binding protein 0.0033 0.0116 0.0333
Schistosoma mansoni tubulin subunit delta 0.0145 0.0771 0.2379
Trypanosoma brucei epsilon tubulin 0.0316 0.1773 0.5508
Brugia malayi bZIP transcription factor family protein 0.0091 0.0457 0.1248
Trypanosoma cruzi epsilon tubulin, putative 0.0345 0.1942 0.6048
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.001 0.003
Loa Loa (eye worm) hypothetical protein 0.0627 0.3595 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.012 0.012
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0247 0.077
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0046 0.0195 0.058
Schistosoma mansoni hypothetical protein 0.0444 0.2523 0.7851
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0076 0.0238
Echinococcus granulosus Tubulin alpha 1 chain 0.0423 0.2401 0.7479
Echinococcus multilocularis lamin dm0 0.0057 0.0258 0.0258
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0171 0.0925 0.288
Trichomonas vaginalis tubulin gamma chain, putative 0.0562 0.3211 1
Schistosoma mansoni tubulin subunit beta 0.0562 0.3211 1
Onchocerca volvulus 0.0171 0.0925 0.5135
Trypanosoma cruzi tubulin delta chain 0.0326 0.1832 0.5705
Brugia malayi AMP-binding enzyme family protein 0.005 0.0218 0.0581
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0252 0.14 0.4359
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.001 0.0027
Trichomonas vaginalis tubulin gamma chain, putative 0.0345 0.1945 0.6056
Schistosoma mansoni hypothetical protein 0.0074 0.0357 0.1085
Trichomonas vaginalis tubulin, putative 0.0171 0.0925 0.288
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0119 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0218 0.2733
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.012 0.0372
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0145 0.0771 1
Leishmania major beta tubulin 0.0562 0.3211 1
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0238 0.0712
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0218 0.2733
Echinococcus granulosus tubulin alpha 3 chain 0.0423 0.2401 0.7479
Loa Loa (eye worm) hypothetical protein 0.0057 0.0258 0.0719
Schistosoma mansoni tubulin subunit alpha 0.0423 0.2401 0.7471
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.012 0.0343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0131 0.1597
Echinococcus granulosus tubulin beta 4A class IVa 0.0562 0.3211 1
Echinococcus multilocularis tubulin alpha 0.0316 0.1773 0.1773
Loa Loa (eye worm) hypothetical protein 0.0321 0.1801 0.501
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0278 0.1553 0.4321
Echinococcus multilocularis GPCR, family 2 0.0033 0.0119 0.0119
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0046 0.0195 0.2437
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0247 0.077
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Trichomonas vaginalis tubulin beta chain, putative 0.0423 0.2401 0.7479
Entamoeba histolytica tubulin alpha chain, putative 0.0423 0.2401 0.7471
Toxoplasma gondii methionine aminopeptidase 0.0046 0.0195 0.058
Loa Loa (eye worm) hypothetical protein 0.0028 0.0085 0.0236
Onchocerca volvulus 0.005 0.0218 0.121
Echinococcus granulosus Tubulin beta 2C chain 0.0562 0.3211 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0423 0.2401 0.2401
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0076 0.0238
Loa Loa (eye worm) alpha-tubulin 0.0423 0.2401 0.6681
Entamoeba histolytica hypothetical protein 0.0075 0.0362 0.11
Trypanosoma brucei beta tubulin 0.0562 0.3211 1
Brugia malayi AMP-binding enzyme family protein 0.005 0.0218 0.0581
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0247 0.077
Schistosoma mansoni single-minded 0.005 0.0219 0.0652
Leishmania major beta tubulin 0.0562 0.3211 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.001 0.003
Plasmodium vivax tubulin alpha chain, putative 0.0423 0.2401 0.7471
Loa Loa (eye worm) tubulin beta chain 0.0145 0.0771 0.2146
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0143 0.0417
Schistosoma mansoni tubulin subunit epsilon 0.0345 0.1942 0.6036
Loa Loa (eye worm) hypothetical protein 0.0278 0.1553 0.4321
Plasmodium falciparum alpha tubulin 2 0.0423 0.2401 0.7471
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.0837 0.2329
Leishmania major beta tubulin 0.0562 0.3211 1
Mycobacterium ulcerans cell division protein FtsZ 0.0145 0.0771 1
Echinococcus granulosus tubulin alpha 0.0316 0.1773 0.5521
Trypanosoma brucei alpha tubulin 0.0423 0.2401 0.7471
Schistosoma mansoni survival motor neuron protein 0.0102 0.0523 0.1602
Trichomonas vaginalis tubulin beta chain, putative 0.0423 0.2401 0.7479
Trypanosoma brucei epsilon tubulin 0.0345 0.1942 0.6036
Toxoplasma gondii alpha tubulin TUBA1 0.0423 0.2401 0.7471
Echinococcus granulosus Tubulin beta 2C chain 0.0562 0.3211 1
Brugia malayi isocitrate dehydrogenase 0.0034 0.012 0.0306
Leishmania major beta tubulin 0.0562 0.3211 1
Toxoplasma gondii beta tubulin 0.0562 0.3211 1
Onchocerca volvulus 0.0015 0.001 0.0054
Onchocerca volvulus 0.0057 0.0258 0.1435
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.001 0.003
Trypanosoma brucei protein kinase, putative 0.0055 0.0247 0.0741
Schistosoma mansoni hypothetical protein 0.036 0.2029 0.6307
Echinococcus multilocularis tubulin alpha 3 chain 0.0423 0.2401 0.2401
Brugia malayi Cytochrome P450 family protein 0.0031 0.0105 0.0264
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0046 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.0399
Leishmania major protein kinase, putative 0.0014 0.0003 0.0009
Trypanosoma brucei zeta tubulin 0.0448 0.2545 0.7918
Schistosoma mansoni alpha tubulin 0.0423 0.2401 0.7471
Leishmania major beta tubulin 0.0562 0.3211 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0562 0.3211 0.8933
Loa Loa (eye worm) methionine aminopeptidase type I 0.0046 0.0195 0.0543
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0247 0.077
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0218 0.065
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0046 0.0195 0.058
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0143 0.7341
Toxoplasma gondii alpha-tubulin I, putative 0.0423 0.2401 0.7471
Schistosoma mansoni tubulin subunit alpha 0.0423 0.2401 0.7471
Echinococcus multilocularis Tubulin beta 2C chain 0.0562 0.3211 0.3211
Schistosoma mansoni hypothetical protein 0.0056 0.0252 0.0757
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0091 0.0457 0.1423
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0269 0.081
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Plasmodium vivax tubulin alpha chain, putative 0.0423 0.2401 0.7471
Loa Loa (eye worm) hypothetical protein 0.005 0.0218 0.0606
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0362 0.0362
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0362 0.11
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0278 0.1553 0.4837
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.012 0.0372
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.012 0.0343
Onchocerca volvulus 0.0057 0.0258 0.1435
Giardia lamblia Beta tubulin 0.0562 0.3211 1
Echinococcus multilocularis dnaJ subfamily B 0.0444 0.2523 0.2523
Echinococcus multilocularis survival motor neuron protein 1 0.0502 0.2862 0.2862
Echinococcus multilocularis tubulin subunit TubB 0.0423 0.2401 0.2401
Trypanosoma cruzi zeta tubulin, putative 0.0448 0.2545 0.7924
Giardia lamblia Alpha-tubulin 0.0423 0.2401 0.7268
Loa Loa (eye worm) tubulin alpha-2 chain 0.0423 0.2401 0.6681
Loa Loa (eye worm) tubulin beta chain 0.0562 0.3211 0.8933
Echinococcus multilocularis Tubulin beta 2C chain 0.0562 0.3211 0.3211
Brugia malayi Cell division protein ftsZ 0.0145 0.0771 0.2124
Trypanosoma brucei alpha tubulin 0.0423 0.2401 0.7471
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0103 0.0286
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.031 0.0939
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0076 0.0208
Brugia malayi hypothetical protein 0.0026 0.0076 0.0186
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.012 0.012
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0143 0.0417
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.012 0.0343
Trypanosoma cruzi beta tubulin, putative 0.0562 0.3211 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0423 0.2401 0.7479
Loa Loa (eye worm) hypothetical protein 0.0072 0.0347 0.0965
Trichomonas vaginalis tubulin alpha chain, putative 0.0562 0.3211 1
Brugia malayi AMP-binding enzyme family protein 0.005 0.0218 0.0581
Treponema pallidum cell division protein FtsZ 0.0145 0.0771 1
Echinococcus granulosus tubulin alpha chain 0.0423 0.2401 0.7479
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Brugia malayi Tubulin alpha chain 0.0145 0.0771 0.2124
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0247 0.077
Brugia malayi hypothetical protein 0.0017 0.0022 0.0034
Brugia malayi hypothetical protein 0.0169 0.0914 0.2522
Echinococcus granulosus beta tubulin 0.0562 0.3211 1
Echinococcus multilocularis hypothetical protein 0.0423 0.2401 0.2401
Echinococcus multilocularis tubulin epsilon chain 0.0345 0.1942 0.1942
Leishmania major beta tubulin 0.0562 0.3211 1
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0218 0.065
Echinococcus granulosus Tubulin alpha 1 chain 0.0423 0.2401 0.7479
Trypanosoma brucei alpha tubulin 0.0423 0.2401 0.7471
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0076 0.0208
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Loa Loa (eye worm) hypothetical protein 0.0056 0.0252 0.0702
Toxoplasma gondii tubulin, putative 0.0029 0.0092 0.0258
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0046 0.0195 0.058
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0247 0.077
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.001 0.0126
Trichomonas vaginalis tubulin alpha chain, putative 0.0171 0.0925 0.288
Echinococcus granulosus peroxisome assembly protein 26 0.0423 0.2401 0.7479
Onchocerca volvulus 0.0054 0.0238 0.1319
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0218 0.0678
Plasmodium vivax tubulin epsilon chain, putative 0.0345 0.1942 0.6036
Leishmania major beta tubulin 0.0562 0.3211 1
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.0771 0.2402
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0046 0.0195 0.0608
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0003 0.0009
Echinococcus multilocularis geminin 0.036 0.2029 0.2029
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0046 0.0195 0.058
Trypanosoma cruzi tubulin delta chain 0.0326 0.1832 0.5705
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0342
Toxoplasma gondii beta-tubulin, putative 0.0562 0.3211 1
Trypanosoma brucei tubulin gamma chain 0.0345 0.1945 0.6044
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0218 0.0678
Trichomonas vaginalis tubulin beta chain, putative 0.0562 0.3211 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.001 0.003
Trypanosoma brucei alpha tubulin, putative 0.0171 0.0925 0.2858
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0326 0.1832 0.5692
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.0219
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0091 0.0457 0.0457
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.012 0.0333
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0076 0.0208
Leishmania major protein kinase, putative 0.0014 0.0003 0.0009
Leishmania major epsilon tubulin, putative 0.0345 0.1942 0.6048
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0076 0.0208
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.012 0.012
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0046 0.0195 0.0608
Entamoeba histolytica hypothetical protein 0.0075 0.0362 0.11
Echinococcus granulosus dnaJ subfamily B 0.0444 0.2523 0.7858
Trypanosoma brucei beta tubulin 0.0562 0.3211 1
Trypanosoma brucei beta tubulin 0.0562 0.3211 1
Mycobacterium leprae cell division protein FtsZ 0.0145 0.0771 1
Entamoeba histolytica tubulin family protein 0.0562 0.3211 1
Schistosoma mansoni tubulin subunit beta 0.0562 0.3211 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0316 0.1773 0.5521
Echinococcus multilocularis musashi 0.0057 0.0258 0.0258
Leishmania major beta tubulin 0.0562 0.3211 1
Brugia malayi beta-tubulin, identical 0.0562 0.3211 0.893
Plasmodium falciparum tubulin gamma chain 0.0345 0.1945 0.6044
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0089 0.0442 0.1231
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0543 0.1487
Loa Loa (eye worm) tubulin alpha 2 0.0107 0.0552 0.1535
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0046 0.0195 0.2532
Brugia malayi hypothetical protein 0.0502 0.2862 0.7956
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.001 0.001
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.001 0.0126
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0046 0.0195 0.2532
Toxoplasma gondii beta-1 tubulin, putative 0.0562 0.3211 1
Loa Loa (eye worm) BEN-1 protein 0.0562 0.3211 0.8933
Trypanosoma cruzi alpha tubulin, putative 0.0423 0.2401 0.7479
Trichomonas vaginalis tubulin gamma chain, putative 0.0345 0.1942 0.6048
Giardia lamblia Gamma tubulin 0.0345 0.1945 0.5727
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0119 0.0305
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.012 0.012
Trichomonas vaginalis tubulin beta chain, putative 0.0171 0.0925 0.288
Echinococcus multilocularis tubulin delta chain 0.0145 0.0771 0.0771
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0119 0.0332
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0003 0.0009
Echinococcus multilocularis peroxisome assembly protein 26 0.0423 0.2401 0.2401
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0543 0.151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0131 0.1597
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0046 0.0195 0.2437
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0258 0.0694
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0046 0.0195 0.058
Trichomonas vaginalis tubulin beta chain, putative 0.0423 0.2401 0.7479
Brugia malayi CXXC zinc finger family protein 0.0031 0.0106 0.0268
Plasmodium falciparum tubulin beta chain 0.0562 0.3211 1
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0342
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0145 0.0771 0.2402
Echinococcus multilocularis cpg binding protein 0.0033 0.0116 0.0116
Brugia malayi Tubulin beta-1 chain 0.0562 0.3211 0.893
Brugia malayi Tubulin beta chain 0.0171 0.0925 0.2553
Trypanosoma brucei beta tubulin 0.0562 0.3211 1
Echinococcus multilocularis tumor protein p63 0.0367 0.2071 0.2071
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.012 0.0343
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0076 0.0208
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0332
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0046 0.0195 0.058
Giardia lamblia Alpha-tubulin 0.0423 0.2401 0.7268
Plasmodium vivax tubulin gamma chain, putative 0.0345 0.1945 0.6044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0119 0.0371
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Echinococcus granulosus tubulin alpha chain 0.0423 0.2401 0.7479
Leishmania major beta tubulin 0.0562 0.3211 1
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0342
Onchocerca volvulus 0.0019 0.0034 0.019
Echinococcus multilocularis Tubulin beta 2C chain 0.0562 0.3211 0.3211
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0142 0.0368
Echinococcus multilocularis tubulin gamma 1 chain 0.0345 0.1945 0.1945
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0085 0.0085
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0106 0.0294
Brugia malayi hypoxia-induced factor 1 0.0156 0.0837 0.2308
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.001 0.003
Echinococcus multilocularis jun protein 0.0091 0.0457 0.0457
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0218 0.2733
Giardia lamblia Delta tubulin 0.0145 0.0771 0.1769
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0362 0.1127
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0247 0.077
Leishmania major gamma-tubulin 0.0345 0.1945 0.6056
Brugia malayi Tubulin beta chain 0.0145 0.0771 0.2124
Loa Loa (eye worm) tubulin alpha chain 0.0423 0.2401 0.6681
Loa Loa (eye worm) hypothetical protein 0.0252 0.14 0.3894
Echinococcus granulosus intermediate filament protein 0.0057 0.0258 0.0805
Echinococcus multilocularis tubulin alpha chain 0.0423 0.2401 0.2401
Giardia lamblia Epsilon tubulin 0.0174 0.0941 0.234
Echinococcus granulosus tubulin alpha 1C chain 0.0423 0.2401 0.7479
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0131 0.1597
Onchocerca volvulus 0.0031 0.0106 0.0587
Schistosoma mansoni jun-related protein 0.0074 0.0357 0.1085
Schistosoma mansoni tubulin subunit beta 0.0562 0.3211 1
Leishmania major beta tubulin 0.0562 0.3211 1
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Echinococcus granulosus alpha tubulin 0.0423 0.2401 0.7479
Entamoeba histolytica tubulin alpha-1 chain 0.0423 0.2401 0.7471
Echinococcus multilocularis tubulin alpha chain 0.0423 0.2401 0.2401
Plasmodium vivax delta tubulin, putative 0.0145 0.0771 0.2379
Brugia malayi Tubulin alpha-2 chain 0.0423 0.2401 0.6672
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0105 0.0291
Schistosoma mansoni hypothetical protein 0.0072 0.0347 0.1053
Loa Loa (eye worm) BEN-1 protein 0.0562 0.3211 0.8933
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0142 0.1734
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.0771 0.2402
Echinococcus multilocularis tubulin alpha 1C chain 0.0423 0.2401 0.2401
Leishmania major beta tubulin 0.0562 0.3211 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0562 0.3211 1
Brugia malayi hypothetical protein 0.0075 0.0362 0.0982
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0316 0.1773 0.5508
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0218 0.2733
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0046 0.0195 0.058
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0247 0.0687
Echinococcus granulosus tubulin alpha 1C chain 0.0423 0.2401 0.7479
Echinococcus multilocularis beta tubulin 0.0562 0.3211 0.3211
Brugia malayi hypothetical protein 0.0321 0.1801 0.4997
Loa Loa (eye worm) tubulin beta-1 chain 0.0562 0.3211 0.8933
Schistosoma mansoni tubulin subunit alpha 0.0423 0.2401 0.7471
Echinococcus granulosus Tubulin beta 2C chain 0.0562 0.3211 1
Mycobacterium ulcerans hypothetical protein 0.005 0.0218 0.2733
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0247 0.0741
Brugia malayi Tubulin alpha chain 0.0423 0.2401 0.6672
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.012 0.0372
Trypanosoma cruzi zeta tubulin, putative 0.0448 0.2545 0.7924
Entamoeba histolytica hypothetical protein 0.0075 0.0362 0.11
Leishmania major beta tubulin 0.0562 0.3211 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.012 0.0372
Loa Loa (eye worm) tubulin alpha chain 0.0423 0.2401 0.6681
Onchocerca volvulus 0.0321 0.1801 1
Echinococcus granulosus tubulin epsilon chain 0.0345 0.1942 0.6048
Trypanosoma brucei methionine aminopeptidase, putative 0.0046 0.0195 0.058
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0046 0.0195 0.0195
Mycobacterium tuberculosis Cell division protein FtsZ 0.0145 0.0771 1
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0347 0.094
Echinococcus granulosus jun protein 0.0091 0.0457 0.1423
Echinococcus multilocularis tubulin alpha chain 0.0423 0.2401 0.2401
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0218 0.2825
Echinococcus granulosus geminin 0.036 0.2029 0.6319
Leishmania major hypothetical protein, conserved 0.0026 0.0076 0.0238
Brugia malayi Tubulin alpha-2 chain 0.0423 0.2401 0.6672
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0003 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0218 0.0678
Trichomonas vaginalis tubulin epsilon chain, putative 0.0145 0.0771 0.2402
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0218 0.2733
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0218 0.2825
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.001 0.003
Chlamydia trachomatis methionine aminopeptidase 0.0046 0.0195 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0085 0.0265
Trichomonas vaginalis tubulin alpha chain, putative 0.0171 0.0925 0.288
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.012 0.0343
Trichomonas vaginalis tubulin epsilon chain, putative 0.0423 0.2401 0.7479
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0247 0.077
Echinococcus granulosus beta tubulin 0.0562 0.3211 1
Schistosoma mansoni lamin 0.0057 0.0258 0.0777
Trichomonas vaginalis tubulin gamma chain, putative 0.0145 0.0771 0.2402
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0143 0.1755
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0218 0.2733
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0212
Echinococcus granulosus tubulin subunit TubB 0.0423 0.2401 0.7479
Entamoeba histolytica tubulin gamma chain 0.0345 0.1945 0.6044
Trypanosoma cruzi tubulin gamma chain 0.0345 0.1945 0.6056
Trypanosoma brucei tubulin delta chain 0.0326 0.1832 0.5692
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0218 0.2733
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0423 0.2401 0.7479
Brugia malayi MAP kinase sur-1 0.0055 0.0247 0.0662
Plasmodium vivax tubulin beta chain, putative 0.0562 0.3211 1
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.0219
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.012 0.012
Echinococcus multilocularis tubulin beta 1 chain 0.0562 0.3211 0.3211
Loa Loa (eye worm) tubulin gamma chain 0.0345 0.1945 0.541
Brugia malayi hypothetical protein 0.0072 0.0342 0.0928
Entamoeba histolytica hypothetical protein 0.0075 0.0362 0.11
Mycobacterium ulcerans methionine aminopeptidase 0.0046 0.0195 0.2437
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.012 0.1442
Schistosoma mansoni intermediate filament proteins 0.0057 0.0258 0.0777
Schistosoma mansoni hypothetical protein 0.036 0.2029 0.6307
Echinococcus granulosus tumor protein p63 0.0367 0.2071 0.645
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0238 0.0661
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.001 0.0126
Trypanosoma cruzi epsilon tubulin, putative 0.0345 0.1942 0.6048
Echinococcus multilocularis tubulin subunit beta 0.0562 0.3211 0.3211
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0247 0.0741
Brugia malayi small heat shock protein 0.0627 0.3595 1
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.001 0.003
Loa Loa (eye worm) beta-tubulin 0.0562 0.3211 0.8933
Echinococcus granulosus cpg binding protein 0.0033 0.0116 0.0362
Plasmodium falciparum alpha tubulin 1 0.0423 0.2401 0.7471
Trichomonas vaginalis tubulin, putative 0.0562 0.3211 1
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Echinococcus granulosus tubulin alpha chain 0.0423 0.2401 0.7479
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0119 0.0371
Toxoplasma gondii methionine aminopeptidase 0.0046 0.0195 0.058
Echinococcus multilocularis tubulin alpha chain 0.0423 0.2401 0.2401
Loa Loa (eye worm) tubulin alpha 2 0.0278 0.1553 0.4321
Echinococcus multilocularis Tubulin alpha 1 chain 0.0423 0.2401 0.2401
Leishmania major zeta tubulin, putative 0.0448 0.2545 0.7924
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0543 0.1487
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0046 0.0195 0.0608
Trichomonas vaginalis tubulin beta chain, putative 0.0423 0.2401 0.7479
Loa Loa (eye worm) hypothetical protein 0.005 0.0218 0.0606
Onchocerca volvulus 0.0102 0.0523 0.2902
Echinococcus granulosus tubulin alpha chain 0.0423 0.2401 0.7479
Echinococcus granulosus lamin 0.0057 0.0258 0.0805
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.0399
Echinococcus granulosus lamin dm0 0.0057 0.0258 0.0805
Onchocerca volvulus 0.0015 0.001 0.0054
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0342
Schistosoma mansoni tubulin subunit beta 0.0562 0.3211 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0562 0.3211 0.3211
Loa Loa (eye worm) tubulin alpha-3 chain 0.0252 0.14 0.3894
Echinococcus granulosus survival motor neuron protein 1 0.0502 0.2862 0.8912
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.001 0.003
Leishmania major beta tubulin 0.0562 0.3211 1
Onchocerca volvulus 0.0015 0.001 0.0054
Schistosoma mansoni hypothetical protein 0.0075 0.0362 0.11
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.005 0.0218 0.0606
Leishmania major beta tubulin 0.0562 0.3211 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0247 0.077
Schistosoma mansoni lamin 0.0057 0.0258 0.0777
Leishmania major beta tubulin 0.0562 0.3211 1
Leishmania major alpha tubulin 0.0423 0.2401 0.7479
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.0399
Brugia malayi Methionine aminopeptidase protein type I 0.0046 0.0195 0.0518
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0247 0.077
Trypanosoma brucei beta tubulin 0.0316 0.1773 0.5508
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.0399

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 1.4 Induction of MCP1 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 1.5 Induction of IL2 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 1.6 Induction of IL3 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 1.7 Induction of IL12p70 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 1.7 Induction of RANTES secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 1.7 Induction of IL10 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 1.9 Induction of IL12p40 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 2.1 Induction of IL15 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 2.1 Induction of IL13 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 2.3 Induction of IL6 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 2.4 Induction of IL8 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 2.4 Induction of IL4 secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 2.8 Induction of IFNgamma secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 3.3 Induction of TNFalpha secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 3.4 Induction of MIPalpha secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107
Activity (functional) = 3.5 Induction of GM-CSF secretion in human CD161+ CD3+ NKT cells at 10 ug/ml after 18 hrs relative to basal level ChEMBL. 17566107

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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