Detailed information for compound 546254

Basic information

Technical information
  • TDR Targets ID: 546254
  • Name: methyl 2-(5',6'-dimethyl-1'-oxo-spiro[3,4-dih ydropyrazole-5,2'-indane]-4-yl)-6-methyl-benz oate
  • MW: 362.422 | Formula: C22H22N2O3
  • H donors: 0 H acceptors: 2 LogP: 4.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(C)cccc1C1CN=NC21Cc1c(C2=O)cc(c(c1)C)C
  • InChi: 1S/C22H22N2O3/c1-12-6-5-7-16(19(12)21(26)27-4)18-11-23-24-22(18)10-15-8-13(2)14(3)9-17(15)20(22)25/h5-9,18H,10-11H2,1-4H3
  • InChiKey: WFCIEHWRWGAYKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(5',6'-dimethyl-1'-oxo-4-spiro[3,4-dihydropyrazole-5,2'-indane]yl)-6-methylbenzoic acid methyl ester
  • methyl 2-(5,6-dimethyl-3-oxo-spiro[1H-indene-2,5'-3,4-dihydropyrazole]-4'-yl)-6-methyl-benzoate
  • 2-(1'-keto-5',6'-dimethyl-spiro[1-pyrazoline-3,2'-indane]-4-yl)-6-methyl-benzoic acid methyl ester
  • methyl 2-(5,6-dimethyl-3-oxospiro[1H-indene-2,5'-3,4-dihydropyrazole]-4'-yl)-6-methylbenzoate
  • methyl 2-(5,6-dimethyl-3-oxospiro[1H-indene-2,3'-4,5-dihydropyrazole]-4'-yl)-6-methylbenzoate
  • methyl 2-(5',6'-dimethyl-1'-oxo-spiro[4,5-dihydropyrazole-3,2'-indane]-4-yl)-6-methyl-benzoate
  • 2-(5',6'-dimethyl-1'-oxo-4-spiro[4,5-dihydropyrazole-3,2'-indane]yl)-6-methylbenzoic acid methyl ester
  • 2-(1'-keto-5',6'-dimethyl-spiro[4,5-dihydropyrazole-3,2'-indane]-4-yl)-6-methyl-benzoic acid methyl ester
  • methyl 2-(5,6-dimethyl-3-oxo-spiro[1H-indene-2,3'-4,5-dihydropyrazole]-4'-yl)-6-methyl-benzoate
  • NCI60_027815
  • AIDS-147757
  • AIDS147757
  • Benzoic acid, 2-methyl-6-(1,3,4',5'-tetrahydro-5,6-dimethyl-1-oxospiro[2H-indene-2,3'-[3H]pyrazol]-4'-yl)-, methyl ester
  • NSC677804

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0324 0.0879
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0215 0.063 0.0792
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.4021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0098 0.0099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0059 0.0055
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0215 0.0212
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0632 0.1967 0.9647
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0283 0.0847 0.4145
Leishmania major glycerol uptake protein, putative 0.0215 0.063 0.327
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0109 0.029 0.0287
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0071 0.0067
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0091 0.024
Brugia malayi Hhat protein 0.0215 0.063 0.0626
Plasmodium falciparum thioredoxin reductase 0.0047 0.0091 0.0747
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.006 0.0279
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0086 0.0215 0.0223
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0483 0.1488 0.7291
Loa Loa (eye worm) hypothetical protein 0.0181 0.052 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0334 0.101 0.4947
Brugia malayi CXXC zinc finger family protein 0.0123 0.0334 0.0331
Mycobacterium tuberculosis Conserved protein 0.0181 0.052 0.1417
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0321 0.1616
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.052 0.0654
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.027 0.0267
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0149 0.0416 0.2156
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.0723 0.072
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.006 0.006
Trypanosoma cruzi glycerol uptake protein, putative 0.0215 0.063 0.327
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.2133 0.2683
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.2156
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0086 0.0215 0.0212
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.052 0.2539
Echinococcus granulosus RUN 0.0041 0.0071 0.0067
Leishmania major cytochrome p450-like protein 0.0023 0.0012 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0059 0.0074
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0617 0.1918 0.1916
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0064 0.006
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0632 0.1967 1
Brugia malayi MBOAT family protein 0.0215 0.063 0.0626
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0343 0.1038 0.1035
Loa Loa (eye worm) hypothetical protein 0.0568 0.176 0.1845
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.021 0.0612 0.4177
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Brugia malayi diacylglycerol acyltransferase 0.0215 0.063 0.0626
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0215 0.063 0.0626
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0053 0.0245
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.027 0.1778
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0086 0.0215 0.0212
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0149 0.0416 0.4021
Leishmania major hypothetical protein, conserved 0.0215 0.063 0.327
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0617 0.1918 0.9408
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.027 0.131
Schistosoma mansoni rab6-interacting 0.0041 0.0071 0.0089
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0065 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0468 0.1441 0.7064
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0109 0.029 0.0365
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0059 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0468 0.1441 0.7064
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0063 0.0944
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0568 0.176 0.1757
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0053 0.0261
Echinococcus multilocularis ubiquitin specific protease 41 0.0109 0.029 0.0287
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0048 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0012 0.0043
Brugia malayi MBOAT family protein 0.0215 0.063 0.0626
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0215 0.0212
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0149 0.0416 0.2156
Schistosoma mansoni lipoxygenase 0.0103 0.0269 0.0338
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.006 0.0295
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0235 0.0692 0.0689
Trichomonas vaginalis transmembrane protein nessy, putative 0.0215 0.063 0.3076
Schistosoma mansoni survival motor neuron protein 0.005 0.0099 0.0125
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0109 0.029 0.0287
Schistosoma mansoni hypothetical protein 0.0215 0.063 0.0792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0091 0.0088
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.009 0.0228 0.0224
Loa Loa (eye worm) hypothetical protein 0.0109 0.029 0.0301
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0617 0.1918 0.9408
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0235 0.0692 0.0689
Echinococcus multilocularis muscleblind protein 0.1686 0.5349 0.5347
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0074 0.0345
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.021 0.0612 0.0609
Loa Loa (eye worm) hypothetical protein 0.0215 0.063 0.0658
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0074 0.0345
Mycobacterium ulcerans putative regulatory protein 0.0334 0.101 0.5128
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0181 0.052 0.1417
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0617 0.1918 0.9408
Schistosoma mansoni sterol O-acyltransferase 1 0.0215 0.063 0.0792
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Onchocerca volvulus 0.0093 0.0237 0.2317
Toxoplasma gondii hypothetical protein 0.0468 0.1441 1
Echinococcus multilocularis tumor protein p63 0.0328 0.0991 0.0988
Leishmania major trypanothione reductase 0.0047 0.0091 0.0458
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.021 0.0612 0.3177
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0149 0.0416 0.0413
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0655 0.2039 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0286 0.0773
Loa Loa (eye worm) MBOAT family protein 0.2497 0.7949 0.8347
Plasmodium falciparum ornithine aminotransferase 0.009 0.0228 0.2121
Loa Loa (eye worm) hypothetical protein 0.0041 0.0071 0.0071
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0343 0.1038 0.1035
Loa Loa (eye worm) hypothetical protein 0.1686 0.5349 0.5615
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0029 0.0124
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.021 0.0612 0.3177
Trichomonas vaginalis conserved hypothetical protein 0.0468 0.1441 0.7064
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0617 0.1918 0.9408
Schistosoma mansoni hypothetical protein 0.0041 0.0071 0.0089
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0215 0.063 0.0792
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0091 0.0088
Echinococcus granulosus ornithine aminotransferase 0.009 0.0228 0.0224
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0109 0.029 0.0287
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0053 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0124
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0149 0.0416 0.0524
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.052 0.2539
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.052 0.2699
Schistosoma mansoni DNA polymerase eta 0.002 0.0003 0.0004
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0149 0.0416 0.0413
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0617 0.1918 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0483 0.1488 0.7291
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0215 0.063 0.0792
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0065 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0124
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0065 0.0322
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0029 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0416 0.2029
Trypanosoma brucei glycerol uptake protein, putative 0.0215 0.063 0.327
Mycobacterium tuberculosis Conserved protein 0.0181 0.052 0.1417
Trypanosoma brucei protein kinase, putative 0.0103 0.027 0.1392
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0215 0.063 0.6167
Loa Loa (eye worm) hypothetical protein 0.1686 0.5349 0.5615
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.021 0.0612 0.5989
Leishmania major cAMP-specific phosphodiesterase, putative 0.0149 0.0416 0.2156
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0038 0.006 0.0295
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.032 0.0967 0.0964
Echinococcus multilocularis Aminotransferase class III 0.009 0.0228 0.0224
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.009 0.0228 0.0615
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0215 0.027
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0017 0.0068
Toxoplasma gondii GAF domain-containing protein 0.0334 0.101 0.6975
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0396 0.0393
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.006 0.0279
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.006 0.0295
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.021 0.0612 0.4177
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.063 0.3076
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0053 0.0261
Schistosoma mansoni loxhd1 0.0041 0.0071 0.0089
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0071 0.0067
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0046 0.0043
Entamoeba histolytica vacuolar protein sorting 26 0.0215 0.063 1
Trypanosoma brucei hypothetical protein, conserved 0.0181 0.052 0.2699
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0071 0.0067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1157 0.3651 1
Mycobacterium ulcerans lipase LipD 0.0181 0.052 0.2631
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0053 0.0797
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0065 0.0322
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0321 0.2134
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0071 0.0543
Leishmania major hypothetical protein, conserved 0.0181 0.052 0.2699
Brugia malayi Inositol-1 0.0039 0.0065 0.0062
Echinococcus granulosus zinc finger protein 0.2282 0.7259 0.7258
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0091 0.0458
Loa Loa (eye worm) hypothetical protein 0.0215 0.063 0.0658
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0334 0.101 0.2761
Giardia lamblia Hypothetical protein 0.0149 0.0416 0.5994
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Brugia malayi Thioredoxin reductase 0.0047 0.0091 0.0088
Loa Loa (eye worm) hypothetical protein 0.0181 0.052 0.0543
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0384 0.038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0109 0.029 0.1409
Brugia malayi hypothetical protein 0.005 0.0098 0.0095
Schistosoma mansoni alpha glucosidase 0.0036 0.0053 0.0067
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0086 0.0215 0.0212
Brugia malayi MH2 domain containing protein 0.0119 0.0322 0.0319
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0053 0.0052
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0215 0.063 0.0626
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0041 0.0038
Brugia malayi beta-lactamase 0.0181 0.052 0.0517
Brugia malayi hypothetical protein 0.0244 0.0723 0.072
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0617 0.1918 0.1916
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.009 0.0228 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0032 0.0041 0.0038
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0286 0.0773
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.027 0.131
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0343 0.1038 0.1306
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Echinococcus granulosus microtubule associated protein 2 0.0684 0.2133 0.213
Brugia malayi hypothetical protein 0.0109 0.0289 0.0286
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0655 0.2039 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0029 0.0124
Mycobacterium tuberculosis Probable hydrolase 0.0181 0.052 0.1417
Mycobacterium tuberculosis Probable reductase 0.0108 0.0286 0.0773
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0215 0.0212
Leishmania major glycerol uptake protein, putative 0.0215 0.063 0.327
Echinococcus multilocularis neuropeptide receptor A26 0.096 0.3017 0.3015
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.072 0.0753
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0109 0.029 0.0365
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0235 0.0692 1
Leishmania major glycerol uptake protein, putative 0.0215 0.063 0.327
Loa Loa (eye worm) MBOAT family protein 0.0215 0.063 0.0658
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0011 0.0007
Loa Loa (eye worm) PDE1B protein 0.0343 0.1038 0.1087
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0124
Giardia lamblia hypothetical protein 0.0149 0.0416 0.5994
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0091 0.0747
Leishmania major hypothetical protein, conserved 0.0149 0.0416 0.2156
Echinococcus multilocularis sterol O acyltransferase 1 0.0215 0.063 0.0626
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.009 0.0228 0.1142
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0617 0.1918 0.9408
Echinococcus multilocularis RUN 0.0041 0.0071 0.0067
Entamoeba histolytica hypothetical protein, conserved 0.0215 0.063 1
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0215 0.063 0.0626
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.027 0.1392
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0149 0.0416 0.0524
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0104 0.0106
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0453 0.045
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.006 0.0436
Mycobacterium tuberculosis Probable aminotransferase 0.0632 0.1967 0.5385
Schistosoma mansoni hypothetical protein 0.0034 0.0048 0.006
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0372 0.1131 0.3092
Plasmodium vivax hypothetical protein, conserved 0.0181 0.052 0.5066
Echinococcus multilocularis ornithine aminotransferase 0.009 0.0228 0.0224
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.021 0.0612 0.3177
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.009 0.0228 0.0615
Brugia malayi follicle stimulating hormone receptor 0.0983 0.3093 0.309
Echinococcus multilocularis muscleblind protein 1 0.1686 0.5349 0.5347
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0186 0.0537 0.2621
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.0723 0.072
Onchocerca volvulus 0.0277 0.0827 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0215 0.063 0.327
Mycobacterium ulcerans hypothetical protein 0.0632 0.1967 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0017 0.0068
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Echinococcus multilocularis ornithine aminotransferase 0.009 0.0228 0.0224
Echinococcus multilocularis dnaJ subfamily B 0.1301 0.4114 0.4112
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.027 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.063 0.3076
Brugia malayi beta-lactamase family protein 0.0181 0.052 0.0517
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.006 0.0296
Schistosoma mansoni zinc finger protein 0.2497 0.7949 1
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0065 0.0062
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0149 0.0416 0.0524
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0109 0.029 0.4582
Echinococcus granulosus ubiquitin specific protease 41 0.0109 0.029 0.0287
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0149 0.0416 0.0413
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0321 0.1616
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.009 0.0228 0.1081
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0215 0.063 0.0626
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0003 0.0004
Toxoplasma gondii ABC1 family protein 0.0181 0.052 0.3534
Schistosoma mansoni cpg binding protein 0.0123 0.0334 0.042
Echinococcus granulosus neuropeptide s receptor 0.096 0.3017 0.3015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0286 0.1378
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0322 0.0335
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0063 0.046
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0372 0.1131 0.5742
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0286 0.0773
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.021 0.0612 0.0609
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0065 0.0314
Leishmania major glycerol uptake protein, putative 0.0215 0.063 0.327
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0109 0.029 0.4164
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0059 0.0294
Brugia malayi Cytochrome P450 family protein 0.0023 0.0012 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0029 0.0124
Loa Loa (eye worm) hypothetical protein 0.005 0.0098 0.01
Brugia malayi MBOAT family protein 0.0215 0.063 0.0626
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0262 0.078 0.0982
Schistosoma mansoni alpha-glucosidase 0.0138 0.0382 0.048
Brugia malayi Muscleblind-like protein 0.1686 0.5349 0.5347
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0283 0.0847 0.4406
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0483 0.1488 0.7291
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0289 0.0363
Schistosoma mansoni inositol monophosphatase 0.0039 0.0065 0.0082
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.027 0.0267
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0098 0.0094
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.027 0.1392
Treponema pallidum alginate O-acetylation protein (algI) 0.0215 0.063 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.4021
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0065 0.0339
Trypanosoma cruzi GUP1, putative 0.0215 0.063 0.327
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0149 0.0416 0.2156
Brugia malayi Cytochrome P450 family protein 0.0051 0.0104 0.0101
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0109 0.029 0.1498
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0149 0.0416 0.0413
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.0967 0.0964
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0617 0.1918 0.9408
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.027 0.0267
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0012 0.0009
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.027 0.0267
Trypanosoma cruzi GUP1, putative 0.0215 0.063 0.327
Trichomonas vaginalis helicase, putative 0.0028 0.0029 0.0124
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0617 0.1918 0.9408
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0215 0.063 0.6167
Loa Loa (eye worm) hypothetical protein 0.0149 0.0416 0.0434
Toxoplasma gondii thioredoxin reductase 0.0047 0.0091 0.0521
Trypanosoma cruzi glycerol uptake protein, putative 0.0215 0.063 0.327
Brugia malayi Doublecortin family protein 0.0041 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0289 0.0286
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0071 0.0067
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0149 0.0416 0.2029
Brugia malayi hypothetical protein 0.0041 0.0071 0.0067
Echinococcus multilocularis beta LACTamase domain containing family member 0.0181 0.052 0.0517
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0109 0.029 0.0287
Plasmodium falciparum GAF domain-related protein, putative 0.0334 0.101 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0324 0.0879
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0029 0.0124
Loa Loa (eye worm) hypothetical protein 0.2654 0.8452 0.8875
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0416 0.2156
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0041 0.0038
Brugia malayi hypothetical protein 0.0041 0.0071 0.0067
Echinococcus granulosus o acyltransferase membrane bound domain 0.0215 0.063 0.0626
Toxoplasma gondii hypothetical protein 0.0334 0.101 0.6975
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0012 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.052 0.0654
Loa Loa (eye worm) hypothetical protein 0.0181 0.052 0.0543
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0453 0.045
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.006 0.0296
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0321 0.0317
Mycobacterium leprae Probable lipase LipE 0.0181 0.052 0.2581
Toxoplasma gondii histone lysine methyltransferase SET1 0.0238 0.0702 0.4811
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0235 0.0692 0.0689
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0013
Onchocerca volvulus 0.0181 0.052 0.601
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.027 0.131
Echinococcus granulosus muscleblind protein 0.1686 0.5349 0.5347
Trichomonas vaginalis conserved hypothetical protein 0.0655 0.2039 1
Leishmania major hypothetical protein, conserved 0.005 0.0098 0.0495
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0053 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.0967 0.0964
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.009 0.0228 0.1142
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0074 0.0573
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0098 0.0571
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.006 0.0289
Brugia malayi Pre-SET motif family protein 0.0243 0.072 0.0717
Entamoeba histolytica hypothetical protein 0.0109 0.0289 0.4558
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0416 0.2156
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0039 0.0065 0.0062
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0176 0.0505 0.0502
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0065 0.0985
Onchocerca volvulus 0.0123 0.0334 0.3584
Mycobacterium tuberculosis Conserved protein 0.0181 0.052 0.1417
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.2029
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0074 0.04
Echinococcus multilocularis cpg binding protein 0.013 0.0356 0.0353
Trichomonas vaginalis esterase, putative 0.0181 0.052 0.2539
Brugia malayi MBOAT family protein 0.0215 0.063 0.0626
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0632 0.1967 1
Echinococcus granulosus tumor protein p63 0.0328 0.0991 0.0988
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Mycobacterium ulcerans putative regulatory protein 0.0334 0.101 0.5128
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0617 0.1918 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0052 0.018
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0617 0.1918 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.006 0.0436
Loa Loa (eye worm) hhat protein 0.0215 0.063 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0124
Schistosoma mansoni hypothetical protein 0.1301 0.4114 0.5175
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0059 0.0074
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0235 0.0692 0.0689
Trypanosoma brucei trypanothione reductase 0.0047 0.0091 0.0458
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0012 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.096 0.3017 0.3015
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0149 0.0416 0.0413
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0098 0.0819
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.052 0.2539
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.3137 1 1
Trypanosoma brucei glucosidase, putative 0.0036 0.0053 0.0261
Loa Loa (eye worm) hypothetical protein 0.0181 0.052 0.0543
Plasmodium vivax phosphodiesterase gamma, putative 0.0149 0.0416 0.4021
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.3137 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0074 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.052 0.2699
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0065 0.229
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0215 0.063 1
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0012 0.0043
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.027 0.1392
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0098 0.0099
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0109 0.029 0.0287
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0017 0.007
Toxoplasma gondii hypothetical protein 0.0215 0.063 0.4301
Loa Loa (eye worm) beta-lactamase 0.0181 0.052 0.0543
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0149 0.0416 0.2029
Onchocerca volvulus 0.0181 0.052 0.601
Loa Loa (eye worm) hhat protein 0.0215 0.063 0.0658
Schistosoma mansoni inositol monophosphatase 0.0039 0.0065 0.0082
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0215 0.063 0.0626
Onchocerca volvulus 0.0048 0.0093 0.0451
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0283 0.0847 0.4145
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0098 0.0495
Mycobacterium leprae conserved hypothetical protein 0.0181 0.052 0.2581
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0149 0.0416 0.2029
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0181 0.052 0.0543
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0396 0.0393
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0063 0.0858
Schistosoma mansoni hypothetical protein 0.005 0.0099 0.0125
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0632 0.1967 0.5385
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0453 0.045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0215 0.063 0.0658
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.009 0.0228 0.1142
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0416 0.2156
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0065 0.0322
Echinococcus granulosus dnaJ subfamily B 0.1301 0.4114 0.4112
Mycobacterium tuberculosis Probable lipase LipE 0.0181 0.052 0.1417
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0215 0.063 0.0792
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.2156
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.032 0.0967 0.1012
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.009 0.0228 0.0615
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.021 0.0612 0.3177
Schistosoma mansoni polycystin 1-related 0.0041 0.0071 0.0089
Trypanosoma brucei hypothetical protein, conserved 0.0149 0.0416 0.2156
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0321 0.0317
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0215 0.063 1
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.029 0.1409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.0967 0.1217
Echinococcus granulosus beta LACTamase domain containing family member 0.0181 0.052 0.0517
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0181 0.052 0.2631
Entamoeba histolytica hypothetical protein 0.0109 0.0289 0.4558
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0109 0.029 0.1498
Echinococcus granulosus Aminotransferase class III 0.009 0.0228 0.0224
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0617 0.1918 0.9408
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0321 0.1657
Loa Loa (eye worm) hypothetical protein 0.0181 0.052 0.0543
Mycobacterium ulcerans hypothetical protein 0.0181 0.052 0.2631
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0091 0.0092
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0053 0.0245
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0053 0.0797
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0568 0.176 0.2214
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0109 0.029 0.1498
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0416 0.2156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0029 0.0124
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0053 0.0245
Brugia malayi MBOAT family protein 0.2497 0.7949 0.7949
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0324 0.1576
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.027 0.1392
Loa Loa (eye worm) inositol-1 0.0039 0.0065 0.0065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0041 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.063 0.3076
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.2133 0.213
Toxoplasma gondii exonuclease III APE 0.0038 0.006 0.0304
Plasmodium falciparum phosphodiesterase delta, putative 0.0149 0.0416 0.4021
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.009 0.0228 0.1081
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0052 0.0133
Loa Loa (eye worm) hypothetical protein 0.0235 0.0692 0.0724
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.2497 0.7949 0.7949
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.052 0.2539
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0416 0.2156
Trichomonas vaginalis set domain proteins, putative 0.0277 0.0827 0.4044
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0124
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0053 0.0245
Entamoeba histolytica hypothetical protein 0.0024 0.0017 0.0214
Trichomonas vaginalis porcupine, putative 0.0215 0.063 0.3076
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0109 0.029 0.1409
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0617 0.1918 0.9408
Mycobacterium tuberculosis Probable lipase LipD 0.0181 0.052 0.1417
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.4021
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0053 0.005
Entamoeba histolytica hypothetical protein 0.0215 0.063 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0149 0.0416 0.0524
Trypanosoma brucei glycerol uptake protein, putative 0.0215 0.063 0.327
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0215 0.063 0.0626
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0181 0.052 0.1417
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.2497 0.7949 0.7949
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0286 0.0773
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0071 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0029 0.0124
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.006 0.0296
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.2029
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0053 0.0256
Loa Loa (eye worm) hypothetical protein 0.0215 0.063 0.0658
Echinococcus granulosus sterol O acyltransferase 1 0.0215 0.063 0.0626
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0059 0.0074
Loa Loa (eye worm) histone methyltransferase 0.0039 0.0065 0.0065
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0215 0.063 0.0626
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0215 0.063 0.0626
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.006 0.0823
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0053 0.0261
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0017 0.007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1598 0.5065 0.5063
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0065 0.0303
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0149 0.0416 0.0524
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0215 0.063 1
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.052 0.2539
Schistosoma mansoni cpg binding protein 0.013 0.0356 0.0448
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0065 0.0322
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.006 0.0057
Onchocerca volvulus 0.0181 0.052 0.601
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0149 0.0416 0.2029
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0099 0.0096
Schistosoma mansoni rab6-interacting 0.0041 0.0071 0.0089
Mycobacterium ulcerans beta-lactamase 0.0181 0.052 0.2631
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0149 0.0416 0.0413
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.006 0.2054
Entamoeba histolytica hypothetical protein 0.0109 0.0289 0.4558
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.006 0.0057
Schistosoma mansoni cpg binding protein 0.013 0.0356 0.0448
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.006 0.0155
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0149 0.0416 0.0434
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0322 0.0335
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.006 0.0905
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.2029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0059 0.0074
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0093 0.0117
Onchocerca volvulus 0.005 0.0099 0.0528
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.009 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0416 0.0434
Loa Loa (eye worm) glutathione reductase 0.0047 0.0091 0.0092
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.027 0.1392
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0098 0.0495
Loa Loa (eye worm) acetyltransferase 0.0143 0.0396 0.0413
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.009 0.0228 0.1142
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0124
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0321 0.087
Plasmodium vivax hypothetical protein, conserved 0.0334 0.101 1
Schistosoma mansoni ap endonuclease 0.0038 0.006 0.0076
Loa Loa (eye worm) MBOAT family protein 0.0215 0.063 0.0658
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0244 0.0723 0.0756
Onchocerca volvulus 0.0041 0.0071 0.0158
Loa Loa (eye worm) hypothetical protein 0.0048 0.0093 0.0094
Plasmodium vivax glutathione reductase, putative 0.0047 0.0091 0.0747
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0617 0.1918 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0453 0.0473
Mycobacterium leprae conserved hypothetical protein 0.0334 0.101 0.5095
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.4021
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0098 0.0819
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0215 0.063 0.0626
Brugia malayi Pre-SET motif family protein 0.0037 0.0059 0.0055
Plasmodium vivax SET domain protein, putative 0.0037 0.0059 0.0421
Echinococcus granulosus o acyltransferase membrane bound domain 0.0215 0.063 0.0626
Loa Loa (eye worm) CXXC zinc finger family protein 0.0123 0.0334 0.0347
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.0967 0.0964
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0011 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0098 0.0819
Brugia malayi glutathione reductase 0.0047 0.0091 0.0088
Schistosoma mansoni ornithine--oxo-acid transaminase 0.009 0.0228 0.0286
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0149 0.0416 0.0413
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0215 0.063 0.0658
Onchocerca volvulus 0.0215 0.063 0.7434
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0053 0.0245
Loa Loa (eye worm) hypothetical protein 0.0181 0.052 0.0543
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0053 0.0245
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0065 0.0062
Brugia malayi Cytochrome P450 family protein 0.0023 0.0012 0.0008
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.009 0.0228 0.0615
Echinococcus granulosus cpg binding protein 0.013 0.0356 0.0353
Brugia malayi hypothetical protein 0.0032 0.0042 0.0038
Leishmania major hypothetical protein, conserved 0.0038 0.006 0.0295
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Echinococcus multilocularis neuropeptide s receptor 0.096 0.3017 0.3015
Toxoplasma gondii hypothetical protein 0.0334 0.101 0.6975
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0617 0.1918 0.2413
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0017 0.0037
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0109 0.029 0.1498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.0967 0.1217
Loa Loa (eye worm) hypothetical protein 0.2988 0.9523 1
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.009 0.0228 0.1081
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.027 0.1392
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0396 0.0499
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0983 0.3093 0.3245
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0149 0.0416 0.2029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0186 0.0537 0.2621
Mycobacterium tuberculosis Probable esterase LipL 0.0181 0.052 0.1417
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0453 0.045
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0235 0.0692 0.0871
Plasmodium vivax ornithine aminotransferase, putative 0.009 0.0228 0.2121
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0343 0.1038 0.1035
Echinococcus multilocularis zinc finger protein 0.2282 0.7259 0.7258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.0967 0.1217
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.006 0.0155
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0617 0.1918 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0053 0.0245
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0321 0.0404
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0149 0.0416 0.4021
Brugia malayi MAP kinase sur-1 0.0103 0.027 0.0267
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0324 0.0879
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.006 0.0707
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0039 0.0065 0.0062
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.006 0.0296
Schistosoma mansoni hypothetical protein 0.0109 0.0289 0.0363
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0289 0.0286
Onchocerca volvulus 0.0041 0.0071 0.0158
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0215 0.063 0.4301
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0071 0.0067
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0215 0.063 0.0626
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0098 0.0094
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0286 0.0773
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0321 0.1616
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0215 0.063 0.0626
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0176 0.0505 0.0502
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.027 0.387
Plasmodium falciparum phosphodiesterase gamma, putative 0.0149 0.0416 0.4021
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0215 0.063 0.0792
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0215 0.063 0.0792
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0071 0.0543
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0215 0.063 0.0658
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0215 0.063 0.4301
Brugia malayi beta-lactamase family protein 0.0181 0.052 0.0517
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0692 0.4742
Onchocerca volvulus 0.0086 0.0215 0.2035
Mycobacterium ulcerans L-lysine aminotransferase 0.009 0.0228 0.1142
Loa Loa (eye worm) hypothetical protein 0.0086 0.0215 0.0222
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0149 0.0416 0.0524
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0617 0.1918 0.9408
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0416 0.2156
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0124
Entamoeba histolytica hypothetical protein 0.0109 0.0289 0.4558
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0416 0.2805
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0181 0.052 0.0517
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0098 0.0495
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0029 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.0967 0.0964
Schistosoma mansoni ap endonuclease 0.0038 0.006 0.0076
Leishmania major glycerol uptake protein, putative 0.0215 0.063 0.327
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0012 0.0043
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.027 0.028
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0321 0.0404
Mycobacterium ulcerans esterase/lipase LipP 0.0181 0.052 0.2631
Mycobacterium ulcerans acetylornithine aminotransferase 0.009 0.0228 0.1142
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0181 0.052 0.1417
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0416 0.2029
Schistosoma mansoni lipoxygenase 0.0176 0.0505 0.0636
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0074 0.04
Plasmodium falciparum glutathione reductase 0.0047 0.0091 0.0747
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0059 0.0055
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.009 0.0228 0.148
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0655 0.2039 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0053 0.0245
Leishmania major hypothetical protein, conserved 0.0149 0.0416 0.2156
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.027 0.1392
Echinococcus granulosus mixed lineage leukemia protein mll 0.0032 0.0041 0.0038
Echinococcus granulosus o acyltransferase membrane bound domain 0.0215 0.063 0.0626
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.006 0.0057
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0149 0.0416 0.0524
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0071 0.0071
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0053 0.005
Schistosoma mansoni alpha-glucosidase 0.0138 0.0382 0.048
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.027 0.034

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.766 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.756 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.591 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.525 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.517 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.241 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.238 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.123 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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