Detailed information for compound 552548

Basic information

Technical information
  • TDR Targets ID: 552548
  • Name: 4-(2-methylprop-2-enoyloxy)butyl 2-methylprop -2-enoate
  • MW: 226.269 | Formula: C12H18O4
  • H donors: 0 H acceptors: 2 LogP: 2.65 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=C)C)OCCCCOC(=O)C(=C)C
  • InChi: 1S/C12H18O4/c1-9(2)11(13)15-7-5-6-8-16-12(14)10(3)4/h1,3,5-8H2,2,4H3
  • InChiKey: XOJWAAUYNWGQAU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methyl-2-propenoic acid 4-(2-methyl-1-oxoallyloxy)butyl ester
  • 2-methylacrylic acid 4-methacryloyloxybutyl ester
  • 1,4-butanediol dimethacrylate
  • 2-methylprop-2-enoic acid 4-(2-methyl-1-oxoprop-2-enoxy)butyl ester
  • 151896-80-9
  • 2082-81-7
  • 148390-75-4
  • X 970
  • 234958_ALDRICH
  • 1,4-Butylene dimethacrylate
  • 1,4-Butylene glycol dimethacrylate
  • 2-Propenoic acid, 2-methyl-, 1,4-butanediyl ester
  • Butanediol dimethacrylate
  • Butylene dimethacrylate
  • CCRIS 7046
  • EINECS 218-218-1
  • HSDB 5467
  • Methacrylic acid, tetramethylene ester
  • Oligotetramethylene glycol dimethacrylate
  • Tetramethylene dimethacrylate
  • Tetramethylene glycol dimethacrylate
  • Tetramethylene methacrylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus muscleblind protein 0.0146 0.1966 0.1966
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0314 0.0314
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0504 0.681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4089 1
Echinococcus granulosus zinc finger protein 0.0019 0.0037 0.0037
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0284 0.0634
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0281 0.0281
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0119 0.1332
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0553 0.0553
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0455 0.0455
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0119 0.1956
Loa Loa (eye worm) hypothetical protein 0.004 0.0352 0.1079
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0504 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0553 0.0553
Brugia malayi jmjC domain containing protein 0.0151 0.2039 0.6225
Brugia malayi PHD-finger family protein 0.0029 0.018 0.0475
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0426 0.1307
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0504 0.681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4089 1
Echinococcus multilocularis lamin 0.0026 0.0147 0.0147
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0284 0.0634
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0553 0.0553
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0119 0.0366
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0082 0.0082
Brugia malayi MH2 domain containing protein 0.0117 0.152 0.4621
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0284 0.0634
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0284 0.0634
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0266 0.0606
Schistosoma mansoni hypothetical protein 0.0029 0.018 0.018
Echinococcus granulosus phd:f box containing protein 0.0025 0.0119 0.0119
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0284 0.0284
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0553 0.0553
Echinococcus granulosus lamin 0.0026 0.0147 0.0147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1247 0.3824
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4089 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0284 0.0634
Schistosoma mansoni alpha glucosidase 0.0035 0.0284 0.0284
Loa Loa (eye worm) RNA binding protein 0.0062 0.0688 0.211
Schistosoma mansoni ap endonuclease 0.0018 0.0026 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0688 0.0688
Brugia malayi PHD-finger family protein 0.0024 0.0117 0.028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4089 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.2596 0.2596
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.2167 0.2167
Loa Loa (eye worm) MBCTL1 0.0053 0.0553 0.1698
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0266 0.3423
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0284 0.3675
Schistosoma mansoni hypothetical protein 0.0166 0.2264 0.2264
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.0053 0.0553 0.1698
Schistosoma mansoni jumonji domain containing protein 0.0132 0.1748 0.1748
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0553 0.1631
Brugia malayi hypothetical protein 0.0086 0.1056 0.3184
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0148 0.0148
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0284 0.0634
Onchocerca volvulus Huntingtin homolog 0.012 0.1567 1
Schistosoma mansoni hypothetical protein 0.0068 0.0772 0.0772
Loa Loa (eye worm) hypothetical protein 0.0026 0.014 0.0429
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0634 0.0634
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0266 0.0816
Loa Loa (eye worm) hypothetical protein 0.0047 0.0455 0.1397
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0119 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0284 0.3675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0426 0.0426
Echinococcus granulosus jumonji domain containing protein 0.004 0.0349 0.0349
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0086 0.1056 0.3239
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0281 0.0281
Brugia malayi beta-NAC-like protein 0.0034 0.0266 0.0742
Schistosoma mansoni alpha-glucosidase 0.0137 0.183 0.183
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0284 0.0634
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0455 0.0455
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0727 0.0727
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0266 0.0591
Schistosoma mansoni hypothetical protein 0.0031 0.0221 0.0221
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0455 0.0455
Brugia malayi RNA binding protein 0.0062 0.0688 0.2046
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0119 0.0119
Schistosoma mansoni bromodomain containing protein 0.0062 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.0031 0.0221 0.0679
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0266 0.3423
Schistosoma mansoni ap endonuclease 0.0018 0.0026 0.0026
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.1173 0.1173
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0366
Brugia malayi hypothetical protein 0.0035 0.0281 0.0789
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0426 0.0426
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0504 0.681
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0504 0.1176
Loa Loa (eye worm) hypothetical protein 0.0232 0.326 1
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0009 0.0028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0221 0.0221
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0119 0.0119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0426 0.0426
Schistosoma mansoni microtubule-associated protein tau 0.0676 1 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0147 0.0147
Onchocerca volvulus 0.0092 0.1147 0.704
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1868 0.4651
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.326 0.326
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0119 0.1332
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0069 0.0797 0.2446
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0082 0.0082
Entamoeba histolytica hypothetical protein 0.0035 0.0281 0.0628
Leishmania major hypothetical protein, conserved 0.0025 0.0119 0.1332
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1966 0.1966
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0727 0.1726
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0504 0.1176
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0221 0.0604
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0504 0.0504
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0504 0.681
Brugia malayi jmjC domain containing protein 0.0025 0.0119 0.0289
Echinococcus granulosus peregrin 0.0031 0.0215 0.0215
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0284 0.0634
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0504 0.0504
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0504 0.0504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0426 0.0426
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.1145 0.1145
Loa Loa (eye worm) hypothetical protein 0.0068 0.0772 0.2368
Echinococcus granulosus GPCR family 2 0.0031 0.0221 0.0221
Onchocerca volvulus Alhambra homolog 0.0029 0.018 0.0229
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0119 0.0119
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0119 0.0119
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0221 0.0221
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0119 0.0119
Trypanosoma brucei protein kinase, putative 0.005 0.0504 0.681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0426 0.0426
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0504 0.1545
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0119 0.1956
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0026 0.5
Entamoeba histolytica hypothetical protein 0.0034 0.0266 0.0591
Loa Loa (eye worm) hypothetical protein 0.0038 0.0317 0.0972
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0147 0.0375
Loa Loa (eye worm) hypothetical protein 0.0064 0.0722 0.2216
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0284 0.0797
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0727 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1247 0.3774
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0688 0.2046
Echinococcus granulosus lysine specific demethylase 5A 0.0094 0.1173 0.1173
Trypanosoma brucei glucosidase, putative 0.0035 0.0284 0.3675
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.028 0.3987 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0221 0.0604
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4089 1
Onchocerca volvulus 0.0047 0.0463 0.2226
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0266 0.0606
Schistosoma mansoni alpha-glucosidase 0.0137 0.183 0.183
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0504 0.681
Plasmodium vivax JmjC domain containing protein 0.0025 0.0119 0.0236
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.028 0.3987 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0284 0.0634
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0281 0.0281
Leishmania major basic transcription factor 3a, putative 0.0034 0.0266 0.3423
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0688 0.0688
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0119 0.0119
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0281 0.0281
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.326 0.326
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0266 0.5026
Brugia malayi hypothetical protein 0.012 0.1567 0.4764
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0042 0.038 0.1166
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0688 0.211
Echinococcus multilocularis GPCR, family 2 0.0031 0.0221 0.0221
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0727 0.0727
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0772 0.2307
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.2596 0.2596
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0266 0.0591
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0727 0.2231
Loa Loa (eye worm) hypothetical protein 0.012 0.1567 0.4806
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0455 0.1397
Brugia malayi mbt repeat family protein 0.0047 0.0455 0.1327
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0504 0.1176
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0053 0.0163
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0634 0.0634
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0281 0.0281
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0455 0.0455
Echinococcus multilocularis zinc finger protein 0.0019 0.0037 0.0037
Brugia malayi Bromodomain containing protein 0.0073 0.0861 0.2582
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.018 0.3219
Echinococcus multilocularis lamin dm0 0.0026 0.0147 0.0147
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0284 0.087
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0266 0.3423
Schistosoma mansoni survival motor neuron protein 0.0047 0.0463 0.0463
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0727 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.018 0.0551
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0688 0.211
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0727 0.0727
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0026 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0504 0.1176
Schistosoma mansoni transcription factor btf3 0.0034 0.0266 0.0266
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0284 0.3675
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4089 1
Brugia malayi MAP kinase sur-1 0.005 0.0504 0.1477
Brugia malayi jmjC domain containing protein 0.0025 0.0119 0.0289
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0463 0.1352
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0455 0.0455
Entamoeba histolytica hypothetical protein 0.0035 0.0281 0.0628
Schistosoma mansoni lamin 0.0026 0.0147 0.0147
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0504 0.0504
Schistosoma mansoni eyes absent homolog 0.0086 0.1056 0.1056
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0151 0.2039 0.2039
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0688 0.0688
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0688 0.0688
Brugia malayi mbt repeat family protein 0.0047 0.0455 0.1327
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0727 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0641 0.1966
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0026 0.0026
Brugia malayi jmjC domain containing protein 0.0025 0.0119 0.0289
Brugia malayi Muscleblind-like protein 0.0146 0.1966 0.5999
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0147 0.0452
Loa Loa (eye worm) hypothetical protein 0.0029 0.018 0.0551
Loa Loa (eye worm) hypothetical protein 0.012 0.1567 0.4806
Loa Loa (eye worm) hypothetical protein 0.0086 0.1056 0.3239
Schistosoma mansoni hypothetical protein 0.0047 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.0026 0.0147 0.0452
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0553 0.0553
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.2167 0.6648
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.018 0.018
Onchocerca volvulus Huntingtin homolog 0.012 0.1567 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0284 0.0634
Brugia malayi Bromodomain containing protein 0.0031 0.0215 0.0584
Schistosoma mansoni hypothetical protein 0.0031 0.0221 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0266 0.0591
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.4089 1
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.028 0.3987 1
Entamoeba histolytica hypothetical protein 0.0035 0.0281 0.0628
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.152 0.4664
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.1173 0.3599
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1247 0.3774
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0504 0.681
Onchocerca volvulus 0.0047 0.0455 0.217
Giardia lamblia PHD finger protein 15 0.0029 0.018 0.0378
Plasmodium falciparum phd finger protein, putative 0.0029 0.018 0.0388
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.4089 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0119 0.0366
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0455 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0266 0.0591
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.028 0.3987 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1966 0.6031
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0151 0.2039 0.2039
Brugia malayi jmjC domain containing protein 0.0094 0.1173 0.3547
Schistosoma mansoni zinc finger protein 0.0019 0.0037 0.0037
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0119 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.152 0.4664
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0314 0.0314
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0119 0.0119
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1868 0.4651
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0221 0.0221
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.028 0.3987 1
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0455 0.0455
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.1173 0.1173
Schistosoma mansoni hypothetical protein 0.0035 0.0281 0.0281
Echinococcus granulosus tar DNA binding protein 0.0062 0.0688 0.0688
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0284 0.0284
Echinococcus multilocularis geminin 0.0166 0.2264 0.2264
Schistosoma mansoni hypothetical protein 0.0031 0.0221 0.0221
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0148 0.0148
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.2167 0.6621
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0119 0.1332
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0688 0.0688
Brugia malayi intermediate filament protein 0.0026 0.0147 0.0375
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0221 0.0679
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0349 0.0349
Treponema pallidum hypothetical protein 0.028 0.3987 0.9747
Plasmodium vivax hypothetical protein, conserved 0.0029 0.018 0.0388
Brugia malayi TAR-binding protein 0.0062 0.0688 0.2046
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.018 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4089 1
Brugia malayi jmjC domain containing protein 0.0025 0.0119 0.0289
Schistosoma mansoni hypothetical protein 0.002 0.0053 0.0053
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0504 0.681
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0119 0.0119
Echinococcus granulosus transcription factor btf3 0.0034 0.0266 0.0266
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0119 0.0119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4089 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1247 0.3824
Schistosoma mansoni lamin 0.0026 0.0147 0.0147
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.4089 1
Echinococcus multilocularis microtubule associated protein 2 0.0676 1 1
Echinococcus multilocularis muscleblind protein 0.0146 0.1966 0.1966
Schistosoma mansoni hypothetical protein 0.0288 0.4111 0.4111
Brugia malayi hypothetical protein 0.0232 0.326 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2167 0.2167
Schistosoma mansoni hypothetical protein 0.0166 0.2264 0.2264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0031 0.0221 0.0221
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0727 1
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.4089 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2167 0.2167
Loa Loa (eye worm) hypothetical protein 0.0146 0.1966 0.6031
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.018 0.3219
Brugia malayi Bromodomain containing protein 0.0038 0.0316 0.0896
Echinococcus granulosus geminin 0.0166 0.2264 0.2264
Echinococcus multilocularis musashi 0.0026 0.0147 0.0147
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0727 0.2169
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0147 0.0452
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0688 0.0688
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0426 0.1237
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0119 0.0236
Echinococcus multilocularis transcription factor btf3 0.0034 0.0266 0.0266
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0082 0.0082
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0284 0.0634
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0504 0.0504
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0504 0.1176
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0119 0.0366
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0119 0.0119
Echinococcus granulosus intermediate filament protein 0.0026 0.0147 0.0147
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0284 0.5396
Echinococcus granulosus lamin dm0 0.0026 0.0147 0.0147
Entamoeba histolytica hypothetical protein 0.0035 0.0281 0.0628
Echinococcus multilocularis peregrin 0.0031 0.0215 0.0215
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.018 0.018

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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